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1. Extracorporeal cardiopulmonary resuscitation versus standard treatment for refractory out-of-hospital cardiac arrest: a Bayesian meta-analysis

Author

Heuts, Samuel, Ubben, Johannes F. H., Kawczynski, Michal J., Gabrio, Andrea, Suverein, Martje M., Delnoij, Thijs S. R., Kavalkova, Petra, Rob, Daniel, Komárek, Arnošt, van der Horst, Iwan C. C., Maessen, Jos G., Yannopoulos, Demetris, Bělohlávek, Jan, Lorusso, Roberto, and van de Poll, Marcel C. G.

Published
2024
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3. International Survey on Mechanical Ventilation During Extracorporeal Membrane Oxygenation

Author

van Minnen, Olivier, Jolink, Floris E.J., van den Bergh, Walter M., Droogh, Joep M., Oude Lansink-Hartgring, Annemieke, Vlaar, Alexander P. J., Raasveld, S. Jorinde, Donker, Dirk W., Hermens, Jeannine A. J., Cornet, Alexander D., Vermeijden, J. Wytze, Oude Velthuis, Bob, van den Brule, Judith M. D., Kraemer, C. V. Elzo, Maas, Jacinta J., Janson, Jeroen, Lopez Matta, Jorge, Delnoij, Thijs S. R., van de Poll, Marcel, Akin, Sakir, de Metz, Jesse, van den Bogaard, Bas, Otterspoor, Luuk, Scholten, Erik, van de Pol, Ineke, Kuijpers, Marijn, van Koppenhagen, Laurien, Dos Reis Miranda, Dinis, Meuwese, Christiaan, and Bunge, Jeroen

Published
2024
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4. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Senta Jorinde Raasveld, Claudia van den Oord, Jimmy Schenk, Walter M. van den Bergh, Annemieke Oude Lansink - Hartgring, Franciska van der Velde, Jacinta J. Maas, Pablo van de Berg, Roberto Lorusso, Thijs S. R. Delnoij, Dinis Dos Reis Miranda, Erik Scholten, Fabio Silvio Taccone, Dieter F. Dauwe, Erwin De Troy, Greet Hermans, Federico Pappalardo, Evgeny Fominskiy, Višnja Ivancan, Robert Bojčić, Jesse de Metz, Bas van den Bogaard, Dirk W. Donker, Christiaan L. Meuwese, Martin De Bakker, Benjamin Reddi, José P. S. Henriques, Lars Mikael Broman, Dave A. Dongelmans, and Alexander P. J. Vlaar

Subjects
Thrombocytopenia, Platelet transfusion, Hemorrhage, Venoarterial extracorporeal membrane oxygenation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-center experiences with high degrees of heterogeneity. Therefore, we aimed to ascertain in a multicenter study the course and occurrence rate of thrombocytopenia, and to assess the association between thrombocytopenia, hemorrhage and platelet transfusion during VA ECMO. Methods This was a sub-study of a multicenter (N = 16) study on transfusion practices in patients on VA ECMO, in which a retrospective cohort (Jan-2018–Jul-2019) focusing on platelets was selected. The primary outcome was thrombocytopenia during VA ECMO, defined as mild (100–150·109/L), moderate (50–100·109/L) and severe (

Published
2023
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6. Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial

Author

Olivier van Minnen, Annemieke Oude Lansink-Hartgring, Bas van den Boogaard, Judith van den Brule, Pierre Bulpa, Jeroen J. H. Bunge, Thijs S. R. Delnoij, Carlos V. Elzo Kraemer, Marijn Kuijpers, Bernard Lambermont, Jacinta J. Maas, Jesse de Metz, Isabelle Michaux, Ineke van de Pol, Marcel van de Poll, S. Jorinde Raasveld, Matthias Raes, Dinis dos Reis Miranda, Erik Scholten, Olivier Simonet, Fabio S. Taccone, Frederic Vallot, Alexander P. J. Vlaar, and Walter M. van den Bergh

Subjects
ECMO, Anticoagulation, Complications, Medicine (General), R5-920
Abstract

Abstract Background Although life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related complications. A feared complication is ischemic stroke for which heparin is routinely administered for which the dosage is usually guided by activated partial thromboplastin time (aPTT). However, there is no relation between aPTT and the rare occurrence of ischemic stroke (1.2%), but there is a relation with the much more frequent occurrence of bleeding complications (55%) and blood transfusion. Both are strongly related to outcome. Methods We will conduct a three-arm non-inferiority randomized controlled trial, in adult patients treated with ECMO. Participants will be randomized between heparin administration with a target of 2–2.5 times baseline aPTT, 1.5–2 times baseline aPTT, or low molecular weight heparin guided by weight and renal function. Apart from anticoagulation targets, treatment will be according to standard care. The primary outcome parameter is a combined endpoint consisting of major bleeding including hemorrhagic stroke, severe thromboembolic complications including ischemic stroke, and mortality at 6 months. Discussion We hypothesize that with lower anticoagulation targets or anticoagulation with LMWH during ECMO therapy, patients will have fewer hemorrhagic complications without an increase in thromboembolic complication or a negative effect on their outcome. If our hypothesis is confirmed, this study could lead to a change in anticoagulation protocols and a better outcome for patients treated with ECMO. Trial registration ClinicalTrials.gov NCT04536272 . Registered on 2 September 2020. Netherlands Trial Register NL7969

Published
2022
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7. Outcomes of Extracorporeal Membrane Oxygenation in COVID-19–Induced Acute Respiratory Distress Syndrome: An Inverse Probability Weighted Analysis

Author

Senta Jorinde Raasveld, MD, Fabio Silvio Taccone, MD, PhD, Lars Mikael Broman, MD, PhD, Greet Hermans, MD, PhD, Philippe Meersseman, MD, PhD, Manuel Quintana Diaz, MD, PhD, Thijs S. R. Delnoij, MD, Marcel van de Poll, MD, PhD, Elisa Gouvea Bogossian, MD, Floor L. F. van Baarle, MD, Koray Durak, BSc, Rashad Zayat, MD, PhD, Annemieke Oude Lansink-Hartgring, MD, PhD, Christiaan L. Meuwese, MD, PhD, Joris J. van der Heijden, MD, PhD, Erwin de Troy, MD, PhD, Dieter Dauwe, MD, PhD, Erik Scholten, MD, Franciska van der Velde, MD, Jacinta J. Maas, MD, PhD, Dinis Dos Reis Miranda, MD, PhD, Marijn Kuijpers, MD, Judith van den Brule, MD, PhD, Walter M. van den Bergh, MD, PhD, and Alexander P. J. Vlaar, MD, PhD

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

IMPORTANCE:. Although venovenous extracorporeal membrane oxygenation (VV ECMO) has been used in case of COVID-19 induced acute respiratory distress syndrome (ARDS), outcomes and criteria for its application should be evaluated. OBJECTIVES:. To describe patient characteristics and outcomes in patients receiving VV ECMO due to COVID-19–induced ARDS and to assess the possible impact of COVID-19 on mortality. DESIGN, SETTING AND PARTICIPANTS:. Multicenter retrospective study in 15 ICUs worldwide. All adult patients (> 18 yr) were included if they received VV ECMO with ARDS as main indication. Two groups were created: a COVID-19 cohort from March 2020 to December 2020 and a “control” non-COVID ARDS cohort from January 2018 to July 2019. MAIN OUTCOMES AND MEASURES:. Collected data consisted of patient demographics, baseline variables, ECMO characteristics, and patient outcomes. The primary outcome was 60-day mortality. Secondary outcomes included patient characteristics, COVID-19–related therapies before and during ECMO and complication rate. To assess the influence of COVID-19 on mortality, inverse probability weighted (IPW) analyses were used to correct for predefined confounding variables. RESULTS:. A total of 193 patients with COVID-19 received VV ECMO. The main indication for VV ECMO consisted of refractory hypoxemia, either isolated or combined with refractory hypercapnia. Complications with the highest occurrence rate included hemorrhage, an additional infectious event or acute kidney injury. Mortality was 35% and 45% at 28 and 60 days, respectively. Those mortality rates did not differ between the first and second waves of COVID-19 in 2020. Furthermore, 60-day mortality was equal between patients with COVID-19 and non-COVID-19–associated ARDS receiving VV ECMO (hazard ratio 60-d mortality, 1.27; 95% CI, 0.82–1.98; p = 0.30). CONCLUSIONS AND RELEVANCE:. Mortality for patients with COVID-19 who received VV ECMO was similar to that reported in other COVID-19 cohorts, although no differences were found between the first and second waves regarding mortality. In addition, after IPW, mortality was independent of the etiology of ARDS.

Published
2022
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8. Functional connectivity in resting‐state networks relates to short‐term global cognitive functioning in cardiac arrest survivors.

Author

Verhulst, Marlous M. L. H., Keijzer, Hanneke M., van Gils, Pauline C. W., van Heugten, Caroline M., Meijer, Frederick J. A., Tonino, Bart A. R., Bonnes, Judith L., Delnoij, Thijs S. R., Hofmeijer, Jeannette, and Helmich, Rick C.

Subjects
LARGE-scale brain networks, EXECUTIVE function, FUNCTIONAL magnetic resonance imaging, MONTREAL Cognitive Assessment, CARDIAC arrest
Abstract

Long‐term cognitive impairment is common in cardiac arrest survivors. Screening to identify patients at risk is recommended. Functional magnetic resonance brain imaging (fMRI) holds potential to contribute to prediction of cognitive outcomes. In this study, we investigated the possible value of early changes in resting‐state networks for predicting short and long‐term cognitive functioning of cardiac arrest survivors. We performed a prospective multicenter cohort study in cardiac arrest survivors in three Dutch hospitals. Resting‐state fMRI scans were acquired within a month after cardiac arrest. We primarily focused on functional connectivity within the default‐mode network (DMN) and salience network (SN), and additionally explored functional connectivity in seven other networks. Cognitive outcome was measured using the Montreal Cognitive Assessment (MoCA) during hospital admission and at 3 and 12 months, and by neuropsychological examination (NPE) at 12 months. We tested mixed effects models to evaluate the value of connectivity within the networks for predicting global cognitive outcomes at the three time points, and long‐term cognitive outcomes in the memory, attention, and executive functioning domains. We included 80 patients (age 60 ± 11 years, 72 (90%) male). MoCA scores increased significantly between hospital admission and 3 months (ΔMoCAhospital‐3M = 2.89, p < 0.01), but not between 3 and 12 months (ΔMoCA3M–12M = 0.38, p = 0.52). Connectivity within the DMN, SN, and dorsal attention network (DAN) was positively related to global cognitive functioning during hospital admission (βDMN = 0.85, p = 0.03; βSN = 1.48, p < 0.01; βDAN = 0.96, p = 0.01), but not at 3 and 12 months. Network connectivity was also unrelated to long‐term memory, attention, or executive functioning. Resting‐state functional connectivity in the DMN, SN, and DAN measured in the first month after cardiac arrest is related to short‐term global, but not long‐term global or domain‐specific cognitive performance of survivors. These results do not support the value of functional connectivity within these RSNs for prediction of long‐term cognitive performance after cardiac arrest. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Outcomes of Extracorporeal Membrane Oxygenation in COVID-19–Induced Acute Respiratory Distress Syndrome: An Inverse Probability Weighted Analysis

Author

Raasveld, Senta Jorinde, Taccone, Fabio Silvio, Broman, Lars Mikael, Hermans, Greet, Meersseman, Philippe, Quintana Diaz, Manuel, Delnoij, Thijs S. R., van de Poll, Marcel, Gouvea Bogossian, Elisa, van Baarle, Floor L. F., Durak, Koray, Zayat, Rashad, Oude Lansink-Hartgring, Annemieke, Meuwese, Christiaan L., van der Heijden, Joris J., de Troy, Erwin, Dauwe, Dieter, Scholten, Erik, van der Velde, Franciska, Maas, Jacinta J., Dos Reis Miranda, Dinis, Kuijpers, Marijn, van den Brule, Judith, van den Bergh, Walter M., and Vlaar, Alexander P. J.

Published
2022
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11. Plant-Endophyte Partnerships to Assist Petroleum Hydrocarbon Remediation

Author

Thijs, S., Weyens, N., Gkorezis, P., Vangronsveld, J., Timmis, Kenneth N., Editor-in-Chief, Boll, Matthias, Series Editor, Geiger, Otto, Series Editor, Goldfine, Howard, Series Editor, Krell, Tino, Series Editor, Lee, Sang Yup, Series Editor, McGenity, Terry J., Series Editor, Rojo, Fernando, Series Editor, Sousa, Diana Z., Series Editor, Stams, Alfons J. M., Series Editor, Steffan, Robert J., Series Editor, and Wilkes, Heinz, Series Editor

Published
2019
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12. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Cyril Camaro, Judith L. Bonnes, Eddy M. Adang, Eva M. Spoormans, Gladys N. Janssens, Nina W. van der Hoeven, Lucia S. Jewbali, Eric A. Dubois, Martijn Meuwissen, Tom A. Rijpstra, Hans A. Bosker, Michiel J. Blans, Gabe B. Bleeker, Rémon Baak, George J. Vlachojannis, Bob J. Eikemans, Pim van der Harst, Iwan C. van der Horst, Michiel Voskuil, Joris J. van der Heijden, Bert Beishuizen, Martin Stoel, Hans van der Hoeven, José P. Henriques, Alexander P. Vlaar, Maarten A. Vink, Bas van den Bogaard, Ton A. Heestermans, Wouter de Ruijter, Thijs S. Delnoij, Harry J. Crijns, Gillian A. Jessurun, Pranobe V. Oemrawsingh, Marcel T. Gosselink, Koos Plomp, Michael Magro, Paul W. Elbers, Peter M. van de Ven, Jorrit S. Lemkes, and Niels van Royen

Subjects
coronary angiography, health care costs, non–ST‐segment–elevation myocardial infarction, out‐of‐hospital cardiac arrest, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background In patients with out‐of‐hospital cardiac arrest without ST‐segment elevation, immediate coronary angiography did not improve clinical outcomes when compared with delayed angiography in the COACT (Coronary Angiography After Cardiac Arrest) trial. Whether 1 of the 2 strategies has benefits in terms of health care resource use and costs is currently unknown. We assess the health care resource use and costs in patients with out‐of‐hospital cardiac arrest. Methods and Results A total of 538 patients were randomly assigned to a strategy of either immediate or delayed coronary angiography. Detailed health care resource use and cost‐prices were collected from the initial hospital episode. A generalized linear model and a gamma distribution were performed. Generic quality of life was measured with the RAND‐36 and collected at 12‐month follow‐up. Overall total mean costs were similar between both groups (EUR 33 575±19 612 versus EUR 33 880±21 044; P=0.86). Generalized linear model: (β, 0.991; 95% CI, 0.894–1.099; P=0.86). Mean procedural costs (coronary angiography and percutaneous coronary intervention, coronary artery bypass graft) were higher in the immediate angiography group (EUR 4384±3447 versus EUR 3028±4220; P

Published
2022
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13. Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht)

Author

Steven J R Meex, Walther N K A van Mook, Iwan C C van der Horst, Jeanette Tas, Coen D A Stehouwer, Rob J J van Gassel, Serge J H Heines, Mark M G Mulder, Nanon F L Heijnen, Melanie J Acampo-de Jong, Julia L M Bels, Frank C Bennis, Marcel Koelmann, Rald V M Groven, Moniek A Donkers, Frank van Rosmalen, Ben J M Hermans, Otto Bekers, Astrid M L Oude Lashof, Fabian H Tijssen, Jan-Willem E M Sels, Chahinda Ghossein-Doha, Rob G H Driessen, Pieter L Kubben, Marcus L F Janssen, Gerry A F Nicolaes, Ulrich Strauch, Zafer Geyik, Thijs S R Delnoij, Kim H M Walraven, Jeanine A M C F Verbunt, Susanne van Santen, Ronny M Schnabel, Marcel J H Aries, Marcel C G van de Poll, Bas C T van Bussel, Joachim E Wildberger, Sander M J van Kuijk, Dennis C J J Bergmans, Paul H M Savelkoul, Alma M A Mingels, and Wolfgang F F A Buhre

Subjects
Medicine
Abstract

Introduction The course of the disease in SARS-CoV-2 infection in mechanically ventilated patients is unknown. To unravel the clinical heterogeneity of the SARS-CoV-2 infection in these patients, we designed the prospective observational Maastricht Intensive Care COVID cohort (MaastrICCht). We incorporated serial measurements that harbour aetiological, diagnostic and predictive information. The study aims to investigate the heterogeneity of the natural course of critically ill patients with a SARS-CoV-2 infection.Methods and analysis Mechanically ventilated patients admitted to the intensive care with a SARS-CoV-2 infection will be included. We will collect clinical variables, vital parameters, laboratory variables, mechanical ventilator settings, chest electrical impedance tomography, ECGs, echocardiography as well as other imaging modalities to assess heterogeneity of the course of a SARS-CoV-2 infection in critically ill patients. The MaastrICCht is also designed to foster various other studies and registries and intends to create an open-source database for investigators. Therefore, a major part of the data collection is aligned with an existing national intensive care data registry and two international COVID-19 data collection initiatives. Additionally, we create a flexible design, so that additional measures can be added during the ongoing study based on new knowledge obtained from the rapidly growing body of evidence. The spread of the COVID-19 pandemic requires the swift implementation of observational research to unravel heterogeneity of the natural course of the disease of SARS-CoV-2 infection in mechanically ventilated patients. Our study design is expected to enhance aetiological, diagnostic and prognostic understanding of the disease. This paper describes the design of the MaastrICCht.Ethics and dissemination Ethical approval has been obtained from the medical ethics committee (Medisch Ethische Toetsingscommissie 2020-1565/3 00 523) of the Maastricht University Medical Centre+ (Maastricht UMC+), which will be performed based on the Declaration of Helsinki. During the pandemic, the board of directors of Maastricht UMC+ adopted a policy to inform patients and ask their consent to use the collected data and to store serum samples for COVID-19 research purposes. All study documentation will be stored securely for fifteen years after recruitment of the last patient. The results will be published in peer-reviewed academic journals, with a preference for open access journals, while particularly considering deposition of the manuscripts on a preprint server early.Trial registration number The Netherlands Trial Register (NL8613).

Published
2020
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14. A Bayesian re-analysis of the INCEPTION-trial

Author

Heuts, Samuel, primary, van de Koolwijk, Anina F, additional, Gabrio, Andrea, additional, Ubben, Johannes F H, additional, van der Horst, Iwan C C, additional, Delnoij, Thijs S R, additional, Suverein, Martje M, additional, Maessen, Jos G, additional, Lorusso, Roberto, additional, and van de Poll, Marcel C G, additional

Published
2023
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15. Cost-effectiveness of extracorporeal cardiopulmonary resuscitation vs. conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a pre-planned, trial-based economic evaluation.

Author

Delnoij, Thijs S R, Suverein, Martje M, Essers, Brigitte A B, Hermanides, Renicus C, Otterspoor, Luuk, Elzo Kraemer, Carlos V, Vlaar, Alexander P J, van der Heijden, Joris J, Scholten, Erik, den Uil, Corstiaan, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C C, Maessen, Jos G, Lorusso, Roberto, van de Poll, Marcel C G, Bruinsma, George J Brandon Bravo, Kraemer, Carlos V Elzo, Jansen, Tim, and van den Bogaard, Bas

Published
2024
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16. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, Schenk, Jimmy, additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, van den Bergh, Walter M., additional, Oude Lansink‐Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, Taccone, Fabio Silvio, additional, Peluso, Lorenzo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Scholten, Erik, additional, Overmars, Martijn, additional, Ivančan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, Hermans, Greet, additional, Broman, Lars Mikael, additional, Henriques, José P. S., additional, and Vlaar, Alexander P. J., additional

Published
2023
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17. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Raasveld, Senta Jorinde, primary, van den Oord, Claudia, additional, Schenk, Jimmy, additional, van den Bergh, Walter M., additional, Oude Lansink - Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Dos Reis Miranda, Dinis, additional, Scholten, Erik, additional, Taccone, Fabio Silvio, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Hermans, Greet, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, Ivancan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, De Bakker, Martin, additional, Reddi, Benjamin, additional, Henriques, José P. S., additional, Broman, Lars Mikael, additional, Dongelmans, Dave A., additional, and Vlaar, Alexander P. J., additional

Published
2023
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18. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction

Author

Eva M Spoormans, Jorrit S Lemkes, Gladys N Janssens, Ouissal Soultana, Nina W van der Hoeven, Lucia S D Jewbali, Eric A Dubois, Martijn Meuwissen, Tom A Rijpstra, Hans A Bosker, Michiel J Blans, Gabe B Bleeker, Remon Baak, Georgios J Vlachojannis, Bob J W Eikemans, Pim van der Harst, Iwan C C van der Horst, Michiel Voskuil, Joris J van der Heijden, Albertus Beishuizen, Martin Stoel, Cyril Camaro, Hans van der Hoeven, José P Henriques, Alexander P J Vlaar, Maarten A Vink, Bas van den Bogaard, Ton A C M Heestermans, Wouter de Ruijter, Thijs S R Delnoij, Harry J G M Crijns, Pranobe V Oemrawsingh, Marcel T M Gosselink, Koos Plomp, Michael Magro, Paul W G Elbers, Peter M van de Ven, Niels van Royen, Cardiology, ACS - Atherosclerosis & ischemic syndromes, Intensive Care Medicine, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, Graduate School, ACS - Heart failure & arrhythmias, General practice, Intensive care medicine, ACS - Diabetes & metabolism, Epidemiology and Data Science, MUMC+: MA Intensive Care (3), Intensive Care, MUMC+: MA Medische Staf IC (9), RS: Carim - V04 Surgical intervention, MUMC+: MA Cardiologie (9), Cardiologie, RS: Carim - H01 Clinical atrial fibrillation, Cardiovascular Centre (CVC), and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
Coronary Angiography/methods, OUTCOMES, PROGNOSIS, Electrocardiography/methods, ECG, IMMEDIATE CORONARY-ANGIOGRAPHY, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Left ventricular function, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], General Medicine, POSTRESUSCITATION ELECTROCARDIOGRAMS, Coronary Angiography, Critical Care and Intensive Care Medicine, Cardiac arrest, Ischaemia, Out-of-Hospital Cardiac Arrest/therapy, Electrocardiography, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Troponin T, Shockable rhythm, Humans, ST Elevation Myocardial Infarction, Cardiology and Cardiovascular Medicine, Out-of-Hospital Cardiac Arrest
Abstract

Aims ST-depression and T-wave inversion are frequently present on the post-resuscitation electrocardiogram (ECG). However, the prognostic value of ischaemic ECG patterns is unknown. Methods and results In this post-hoc subgroup analysis of the Coronary Angiography after Cardiac arrest (COACT) trial, the first in-hospital post-resuscitation ECG in out-of-hospital cardiac arrest patients with a shockable rhythm was analysed for ischaemic ECG patterns. Ischaemia was defined as ST-depression of ≥0.1 mV, T-wave inversion in ≥2 contiguous leads, or both. The primary endpoint was 90-day survival. Secondary endpoints were rate of acute unstable lesions, levels of serum troponin-T, and left ventricular function. Of the 510 out-of-hospital cardiac arrest patients, 340 (66.7%) patients had ischaemic ECG patterns. Patients with ischaemic ECG patterns had a worse 90-day survival compared with those without [hazard ratio 1.51; 95% confidence interval (CI) 1.08–2.12; P = 0.02]. A higher sum of ST-depression was associated with lower survival (log-rank = 0.01). The rate of acute unstable lesions (14.5 vs. 15.8%; odds ratio 0.90; 95% CI 0.51–1.59) did not differ between the groups. In patients with ischaemic ECG patterns, maximum levels of serum troponin-T (μg/L) were higher [0.595 (interquartile range 0.243–1.430) vs. 0.359 (0.159–0.845); ratio of geometric means 1.58; 1.13–2.20] and left ventricular function (%) was worse (44.7 ± 12.5 vs. 49.9 ± 13.3; mean difference −5.13; 95% CI −8.84 to −1.42). Adjusted for age and time to return of spontaneous circulation, ischaemic ECG patterns were no longer associated with survival. Conclusion Post-arrest ischaemic ECG patterns were associated with worse 90-day survival. A higher sum of ST-depression was associated with lower survival. Adjusted for age and time to return of spontaneous circulation, ischaemic ECG patterns were no longer associated with survival.

Published
2022
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19. bodemleven (her)ontdekken

Author

Gijbels, M., Thijs, S., Gijbels, M., and Thijs, S.

Abstract

Een goede opbrengst en kwaliteit van je gewassen hangt nauw samen met de kwaliteit van je landbouwgrond. Bodemleven is een essentieel onderdeel van bodemkwaliteit, maar wordt vandaag de dag vaak over het hoofd gezien. Wat houdt een goed bodemleven juist in en hoe kan je hier naar toe werken?

Published
2023

22. Temporary mechanical circulatory support for COVID‐19 patients: A systematic review of literature

Author

Silvia Mariani, Maria Elena De Piero, Justine M. Ravaux, Alexander Saelmans, Michal J. Kawczynski, Bas C. T. van Bussel, Michele Di Mauro, Anne Willers, Justyna Swol, Mariusz Kowalewski, Tong Li, Thijs S. R. Delnoij, Iwan C. C. van der Horst, Jos Maessen, and Roberto Lorusso

Subjects
Adult, Shock, Cardiogenic, SOCIETY, LIFE-SUPPORT, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, PULMONARY, extracorporeal life support, 1ST, EXTRACORPOREAL MEMBRANE-OXYGENATION, Biomaterials, VENTRICULAR ASSIST DEVICE, Humans, extra-corporeal membrane oxygenation, Heart Failure, mechanical circulatory support, OUTCOMES, CRITICALLY-ILL, COVID-19, General Medicine, Middle Aged, TRENDS, Treatment Outcome, Female, Heart-Assist Devices, ECMO
Abstract

OBJECTIVE: Myocardial damage occurs in up to 25% of coronavirus disease 2019 (COVID-19) cases. While veno-venous extracorporeal life support (V-V ECLS) is used as respiratory support, mechanical circulatory support (MCS) may be required for severe cardiac dysfunction. This systematic review summarizes the available literature regarding MCS use rates, disease drivers for MCS initiation, and MCS outcomes in COVID-19 patients. METHODS: PubMed/EMBASE were searched until October 14, 2021. Articles including adults receiving ECLS for COVID-19 were included. The primary outcome was the rate of MCS use. Secondary outcomes included mortality at follow-up, ECLS conversion rate, intubation-to-cannulation time, time on ECLS, cardiac diseases, use of inotropes, and vasopressors. RESULTS: Twenty-eight observational studies (comprising both ECLS-only populations and ECLS patients as part of larger populations) included 4218 COVID-19 patients (females: 28.8%; median age: 54.3 years, 95%CI: 50.7-57.8) of whom 2774 (65.8%) required ECLS with the majority (92.7%) on V-V ECLS, 4.7% on veno-arterial ECLS and/or Impella, and 2.6% on other ECLS. Acute heart failure, cardiogenic shock, and cardiac arrest were reported in 7.8%, 9.7%, and 6.6% of patients, respectively. Vasopressors were used in 37.2%. Overall, 3.1% of patients required an ECLS change from V-V ECLS to MCS for heart failure, myocarditis, or myocardial infarction. The median ECLS duration was 15.9 days (95%CI: 13.9-16.3), with an overall survival of 54.6% and 28.1% in V-V ECLS and MCS patients. One study reported 61.1% survival with oxy-right ventricular assist device. CONCLUSION: MCS use for cardiocirculatory compromise has been reported in 7.3% of COVID-19 patients requiring ECLS, which is a lower percentage compared to the incidence of any severe cardiocirculatory complication. Based on the poor survival rates, further investigations are warranted to establish the most appropriated indications and timing for MCS in COVID-19.

Published
2022
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26. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Camaro, Cyril, Bonnes, Judith L., Adang, Eddy M., Spoormans, Eva M., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Rémon, Vlachojannis, George J., Eikemans, Bob J., van der Harst, Pim, van der Horst, Iwan C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A., de Ruijter, Wouter, Delnoij, Thijs S., Crijns, Harry J., Jessurun, Gillian A., Oemrawsingh, Pranobe V., Gosselink, Marcel T., Plomp, Koos, Magro, Michael, Elbers, Paul W., van de Ven, Peter M., Lemkes, Jorrit S., van Royen, Niels, Camaro, Cyril, Bonnes, Judith L., Adang, Eddy M., Spoormans, Eva M., Janssens, Gladys N., van der Hoeven, Nina W., Jewbali, Lucia S., Dubois, Eric A., Meuwissen, Martijn, Rijpstra, Tom A., Bosker, Hans A., Blans, Michiel J., Bleeker, Gabe B., Baak, Rémon, Vlachojannis, George J., Eikemans, Bob J., van der Harst, Pim, van der Horst, Iwan C., Voskuil, Michiel, van der Heijden, Joris J., Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P., Vlaar, Alexander P., Vink, Maarten A., van den Bogaard, Bas, Heestermans, Ton A., de Ruijter, Wouter, Delnoij, Thijs S., Crijns, Harry J., Jessurun, Gillian A., Oemrawsingh, Pranobe V., Gosselink, Marcel T., Plomp, Koos, Magro, Michael, Elbers, Paul W., van de Ven, Peter M., Lemkes, Jorrit S., and van Royen, Niels

Published
2022

27. Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial.

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J H, Delnoij, Thijs S R, Elzo Kraemer, Carlos V, Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J, de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S Jorinde, Raes, Matthias, Dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S, Vallot, Frederic, Vlaar, Alexander P J, van den Bergh, Walter M, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J H, Delnoij, Thijs S R, Elzo Kraemer, Carlos V, Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J, de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S Jorinde, Raes, Matthias, Dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S, Vallot, Frederic, Vlaar, Alexander P J, and van den Bergh, Walter M

Abstract

Although life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related complications. A feared complication is ischemic stroke for which heparin is routinely administered for which the dosage is usually guided by activated partial thromboplastin time (aPTT). However, there is no relation between aPTT and the rare occurrence of ischemic stroke (1.2%), but there is a relation with the much more frequent occurrence of bleeding complications (55%) and blood transfusion. Both are strongly related to outcome. We will conduct a three-arm non-inferiority randomized controlled trial, in adult patients treated with ECMO. Participants will be randomized between heparin administration with a target of 2-2.5 times baseline aPTT, 1.5-2 times baseline aPTT, or low molecular weight heparin guided by weight and renal function. Apart from anticoagulation targets, treatment will be according to standard care. The primary outcome parameter is a combined endpoint consisting of major bleeding including hemorrhagic stroke, severe thromboembolic complications including ischemic stroke, and mortality at 6 months. We hypothesize that with lower anticoagulation targets or anticoagulation with LMWH during ECMO therapy, patients will have fewer hemorrhagic complications without an increase in thromboembolic complication or a negative effect on their outcome. If our hypothesis is confirmed, this study could lead to a change in anticoagulation protocols and a better outcome for patients treated with ECMO. ClinicalTrials.gov NCT04536272 . Registered on 2 September 2020. Netherlands Trial Register NL7969.

Published
2022

28. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, Soultana, Ouissal, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, and van Royen, Niels

Published
2022

29. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Camaro, Cyril, Bonnes, Judith L, Adang, Eddy M, Spoormans, Eva M, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, George J, Eikemans, Bob J, van der Harst, Pim, van der Horst, Iwan C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Bert, Stoel, Martin, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A, de Ruijter, Wouter, Delnoij, Thijs S, Crijns, Harry J, Jessurun, Gillian A, Oemrawsingh, Pranobe V, Gosselink, Marcel T, Plomp, Koos, Magro, Michael, Elbers, Paul W, van de Ven, Peter M, Lemkes, Jorrit S, and van Royen, Niels

Published
2022

30. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, Elbers, Paul W G, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, Girbes, Armand R J, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, van de Ven, Peter M, van Royen, Niels, and Elbers, Paul W G

Published
2022

31. Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials’ post-hoc subgroup analysis

Author

Spoormans, Eva M, primary, Lemkes, Jorrit S, additional, Janssens, Gladys N, additional, Soultana, Ouissal, additional, van der Hoeven, Nina W, additional, Jewbali, Lucia S D, additional, Dubois, Eric A, additional, Meuwissen, Martijn, additional, Rijpstra, Tom A, additional, Bosker, Hans A, additional, Blans, Michiel J, additional, Bleeker, Gabe B, additional, Baak, Remon, additional, Vlachojannis, Georgios J, additional, Eikemans, Bob J W, additional, van der Harst, Pim, additional, van der Horst, Iwan C C, additional, Voskuil, Michiel, additional, van der Heijden, Joris J, additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P, additional, Vlaar, Alexander P J, additional, Vink, Maarten A, additional, van den Bogaard, Bas, additional, Heestermans, Ton A C M, additional, de Ruijter, Wouter, additional, Delnoij, Thijs S R, additional, Crijns, Harry J G M, additional, Oemrawsingh, Pranobe V, additional, Gosselink, Marcel T M, additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W G, additional, van de Ven, Peter M, additional, and van Royen, Niels, additional

Published
2022
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32. Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial

Author

van Minnen, Olivier, primary, Oude Lansink-Hartgring, Annemieke, additional, van den Boogaard, Bas, additional, van den Brule, Judith, additional, Bulpa, Pierre, additional, Bunge, Jeroen J. H., additional, Delnoij, Thijs S. R., additional, Elzo Kraemer, Carlos V., additional, Kuijpers, Marijn, additional, Lambermont, Bernard, additional, Maas, Jacinta J., additional, de Metz, Jesse, additional, Michaux, Isabelle, additional, van de Pol, Ineke, additional, van de Poll, Marcel, additional, Raasveld, S. Jorinde, additional, Raes, Matthias, additional, dos Reis Miranda, Dinis, additional, Scholten, Erik, additional, Simonet, Olivier, additional, Taccone, Fabio S., additional, Vallot, Frederic, additional, Vlaar, Alexander P. J., additional, and van den Bergh, Walter M., additional

Published
2022
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33. Temporary mechanical circulatory support for COVID‐19 patients: A systematic review of literature

Author

Mariani, Silvia, primary, De Piero, Maria Elena, additional, Ravaux, Justine M., additional, Saelmans, Alexander, additional, Kawczynski, Michal J., additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Willers, Anne, additional, Swol, Justyna, additional, Kowalewski, Mariusz, additional, Li, Tong, additional, Delnoij, Thijs S. R., additional, van der Horst, Iwan C. C., additional, Maessen, Jos, additional, and Lorusso, Roberto, additional

Published
2022
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34. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Senta Jorinde Raasveld, Mina Karami, Walter M. van den Bergh, Annemieke Oude Lansink-Hartgring, Franciska van der Velde, Jacinta J. Maas, Pablo van de Berg, Maarten de Haan, Roberto Lorusso, Thijs S. R. Delnoij, Dinis Dos Reis Miranda, Loes Mandigers, Erik Scholten, Martijn Overmars, Fabio Silvio Taccone, Alexandre Brasseur, Dieter F. Dauwe, Erwin De Troy, Greet Hermans, Philippe Meersseman, Federico Pappalardo, Evgeny Fominskiy, Višnja Ivancan, Robert Bojčić, Jesse de Metz, Bas van den Bogaard, Dirk W. Donker, Christiaan L. Meuwese, Martin de Bakker, Benjamin Reddi, Sanne de Bruin, Wim K. Lagrand, José P. S. Henriques, Lars M. Broman, Alexander P. J. Vlaar, Intensive Care, Graduate School, Intensive Care Medicine, Cardiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, ANS - Neuroinfection & -inflammation, ACS - Microcirculation, CTC, MUMC+: MA Med Staf Spec CTC (9), RS: Carim - V04 Surgical intervention, MUMC+: MA Medische Staf IC (9), MUMC+: MA Med Staf Spec Cardiologie (9), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Cardiovascular and Respiratory Physiology, and TechMed Centre

Subjects
Adult, Male, Croatia, RESPIRATORY-FAILURE, LIFE-SUPPORT, Critical Care and Intensive Care Medicine, Cohort Studies, Belgium, threshold, Humans, Netherlands, Retrospective Studies, transfusion, Sweden, 22/3 OA procedure, Australia, ADULTS, Middle Aged, extracorporeal membrane oxygenation, mortality, Intensive Care Units, Treatment Outcome, Italy, Female, Erythrocyte Transfusion, REQUIREMENTS, red blood cells
Abstract

OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane oxygenation, guidelines suggest liberal thresholds, and a clear overview of RBC transfusion practice is lacking. This study aims to create an overview of RBC transfusion in venovenous extracorporeal membrane oxygenation. DESIGN: Mixed method approach combining multicenter retrospective study and survey. SETTING: Sixteen ICUs worldwide. PATIENTS: Patients receiving venovenous extracorporeal membrane oxygenation between January 2018 and July 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the proportion receiving RBC, the amount of RBC units given daily and in total. Furthermore, the course of hemoglobin over time during extracorporeal membrane oxygenation was assessed. Demographics, extracorporeal membrane oxygenation characteristics, and patient outcome were collected. Two-hundred eight patients received venovenous extracorporeal membrane oxygenation, 63% male, with an age of 55 years (45-62 yr), mainly for acute respiratory distress syndrome. Extracorporeal membrane oxygenation duration was 9 days (5-14 d). Prior to extracorporeal membrane oxygenation, hemoglobin was 10.8 g/dL (8.9-13.0 g/dL), decreasing to 8.7 g/dL (7.7-9.8 g/dL) during extracorporeal membrane oxygenation. Nadir hemoglobin was lower on days when a transfusion was administered (8.1 g/dL [7.4-9.3 g/dL]). A vast majority of 88% patients received greater than or equal to 1 RBC transfusion, consisting of 1.6 U (1.3-2.3 U) on transfusion days. This high transfusion occurrence rate was also found in nonbleeding patients (81%). Patients with a liberal transfusion threshold (hemoglobin > 9 g/dL) received more RBC in total per transfusion day and extracorporeal membrane oxygenation day. No differences in survival, hemorrhagic and thrombotic complication rates were found between different transfusion thresholds. Also, 28-day mortality was equal in transfused and nontransfused patients. CONCLUSIONS: Transfusion of RBC has a high occurrence rate in patients on venovenous extracorporeal membrane oxygenation, even in nonbleeding patients. There is a need for future studies to find optimal transfusion thresholds and triggers in patients on extracorporeal membrane oxygenation.

Published
2022

36. Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Author

Camaro, Cyril, primary, Bonnes, Judith L., additional, Adang, Eddy M., additional, Spoormans, Eva M., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Rémon, additional, Vlachojannis, George J., additional, Eikemans, Bob J., additional, van der Harst, Pim, additional, van der Horst, Iwan C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Bert, additional, Stoel, Martin, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S., additional, Crijns, Harry J., additional, Jessurun, Gillian A., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T., additional, Plomp, Koos, additional, Magro, Michael, additional, Elbers, Paul W., additional, van de Ven, Peter M., additional, Lemkes, Jorrit S., additional, and van Royen, Niels, additional

Published
2022
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37. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, van den Bergh, Walter M., additional, Oude Lansink-Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Scholten, Erik, additional, Overmars, Martijn, additional, Silvio Taccone, Fabio, additional, Brasseur, Alexandre, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Hermans, Greet, additional, Meersseman, Philippe, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, Ivancan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, de Bruin, Sanne, additional, Lagrand, Wim K., additional, Henriques, José P. S., additional, Broman, Lars M., additional, and Vlaar, Alexander P. J., additional

Published
2022
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39. MAPK pathway activity plays a key role in PD-L1 expression of lung adenocarcinoma cells

Author

Steven de Jong, Anton G.T. Terwisscha van Scheltinga, Thijs S. Stutvoet, Arjan Kol, Rudolf S N Fehrmann, Elisabeth G.E. de Vries, Marco de Bruyn, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Targeted Gynaecologic Oncology (TARGON)

Subjects
0301 basic medicine, MAPK/ERK pathway, Lung Neoplasms, RNA Stability, non-small cell lung cancer (NSCLC), programmed death‐ligand 1 (PD‐L1), UP-REGULATION, T-CELL, B7-H1 Antigen, 0302 clinical medicine, CLASS-I, EGFR inhibitors, DOCETAXEL, IFN-GAMMA, Hepatocyte Growth Factor, ACTIVATED PROTEIN-KINASE, BREAST-CANCER CELLS, Original Papers, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Adenocarcinoma, Erlotinib, Mitogen-Activated Protein Kinases, Signal Transduction, medicine.drug, MHC‐I, Adenocarcinoma of Lung, Antineoplastic Agents, IFN gamma, Gene Expression Regulation, Enzymologic, Pathology and Forensic Medicine, Interferon-gamma, 03 medical and health sciences, Downregulation and upregulation, medicine, ROS1, MHC-I, non‐small cell lung cancer (NSCLC), Humans, RNA, Messenger, Protein Kinase Inhibitors, Original Paper, Epidermal Growth Factor, business.industry, MAPK pathway, SELUMETINIB, programmed death-ligand 1 (PD-L1), medicine.disease, Coculture Techniques, 030104 developmental biology, A549 Cells, Cancer research, Selumetinib, KRAS-MUTANT, business, INHIBITORS, IFNγ
Abstract

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have improved the survival of patients with non-small cell lung cancer (NSCLC). Still, many patients do not respond to these inhibitors. PD-L1 (CD274) expression, one of the factors that influences the efficacy of immune checkpoint inhibitors, is dynamic. Here, we studied the regulation of PD-L1 expression in NSCLC without targetable genetic alterations in EGFR, ALK, BRAF, ROS1, MET, ERBB2 and RET. Analysis of RNA sequencing data from these NSCLCs revealed that inferred IFN gamma, EGFR and MAPK signaling correlated with CD274 gene expression in lung adenocarcinoma. In a representative lung adenocarcinoma cell line panel, stimulation with EGF or IFN gamma increased CD274 mRNA and PD-L1 protein and membrane levels, which were further enhanced by combining EGF and IFN gamma. Similarly, tumor cell PD-L1 membrane levels increased after coculture with activated peripheral blood mononuclear cells. Inhibition of the MAPK pathway, using EGFR inhibitors cetuximab and erlotinib or the MEK 1 and 2 inhibitor selumetinib, prevented EGF- and IFN gamma-induced CD274 mRNA and PD-L1 protein and membrane upregulation, but had no effect on IFN gamma-induced MHC-I upregulation. Interestingly, although IFN gamma increases transcriptional activity of CD274, MAPK signaling also increased stabilization of CD274 mRNA. In conclusion, MAPK pathway activity plays a key role in EGF- and IFN gamma-induced PD-L1 expression in lung adenocarcinoma without targetable genetic alterations and may present a target to improve the efficacy of immunotherapy. (c) 2019 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Published
2019
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41. First observations and performance of the RPW instrument on board the Solar Orbiter mission

Author

Maksimovic, M., primary, Souček, J., additional, Chust, T., additional, Khotyaintsev, Y., additional, Kretzschmar, M., additional, Bonnin, X., additional, Vecchio, A., additional, Alexandrova, O., additional, Bale, S. D., additional, Bérard, D., additional, Brochot, J.-Y., additional, Edberg, N. J. T., additional, Eriksson, A., additional, Hadid, L. Z., additional, Johansson, E. P. G., additional, Karlsson, T., additional, Katra, B., additional, Krasnoselskikh, V., additional, Krupař, V., additional, Lion, S., additional, Lorfèvre, E., additional, Matteini, L., additional, Nguyen, Q. N., additional, Píša, D., additional, Piberne, R., additional, Plettemeier, D., additional, Rucker, H. O., additional, Santolík, O., additional, Steinvall, K., additional, Steller, M., additional, Štverák, Š., additional, Trávníček, P., additional, Vaivads, A., additional, Zaslavsky, A., additional, Chaintreuil, S., additional, Dekkali, M., additional, Astier, P.-A., additional, Barbary, G., additional, Boughedada, K., additional, Cecconi, B., additional, Chapron, F., additional, Collin, C., additional, Dias, D., additional, Guéguen, L., additional, Lamy, L., additional, Leray, V., additional, Malac-Allain, L. R., additional, Pantellini, F., additional, Parisot, J., additional, Plasson, P., additional, Thijs, S., additional, Fratter, I., additional, Bellouard, E., additional, Danto, P., additional, Julien, S., additional, Guilhem, E., additional, Fiachetti, C., additional, Sanisidro, J., additional, Laffaye, C., additional, Gonzalez, F., additional, Pontet, B., additional, Quéruel, N., additional, Jannet, G., additional, Fergeau, P., additional, Dudok de Wit, T., additional, Vincent, T., additional, Agrapart, C., additional, Pragout, J., additional, Bergerard-Timofeeva, M., additional, Delory, G. T., additional, Turin, P., additional, Jeandet, A., additional, Leroy, P., additional, Pellion, J.-C., additional, Bouzid, V., additional, Recart, W., additional, Kolmašová, I., additional, Krupařová, O., additional, Uhlíř, L., additional, Lán, R., additional, Baše, J., additional, André, M., additional, Bylander, L., additional, Cripps, V., additional, Cully, C., additional, Jansson, S.-E., additional, Puccio, W., additional, Břínek, J., additional, Ottacher, H., additional, Angelini, V., additional, Berthomier, M., additional, Evans, V., additional, Goetz, K., additional, Hellinger, P., additional, Horbury, T. S., additional, Issautier, K., additional, Kontar, E., additional, Le Contel, O., additional, Louarn, P., additional, Martinović, M., additional, Müller, D., additional, O’Brien, H., additional, Owen, C. J., additional, Retino, A., additional, Rodríguez-Pacheco, J., additional, Sahraoui, F., additional, Sanchez, L., additional, Walsh, A. P., additional, Wimmer-Schweingruber, R. F., additional, and Zouganelis, I., additional

Published
2021
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42. The Solar Orbiter Radio and Plasma Waves (RPW) instrument (Corrigendum)

Author

Maksimovic, M., primary, Bale, S. D., additional, Chust, T., additional, Khotyaintsev, Y., additional, Krasnoselskikh, V., additional, Kretzschmar, M., additional, Plettemeier, D., additional, Rucker, H. O., additional, Souček, J., additional, Steller, M., additional, Štverák, Š., additional, Trávníček, P., additional, Vaivads, A., additional, Chaintreuil, S., additional, Dekkali, M., additional, Alexandrova, O., additional, Astier, P.-A., additional, Barbary, G., additional, Bérard, D., additional, Bonnin, X., additional, Boughedada, K., additional, Cecconi, B., additional, Chapron, F., additional, Chariet, M., additional, Collin, C., additional, de Conchy, Y., additional, Dias, D., additional, Guéguen, L., additional, Lamy, L., additional, Leray, V., additional, Lion, S., additional, Malac-Allain, L. R., additional, Matteini, L., additional, Nguyen, Q. N., additional, Pantellini, F., additional, Parisot, J., additional, Plasson, P., additional, Thijs, S., additional, Vecchio, A., additional, Fratter, I., additional, Bellouard, E., additional, Lorfèvre, E., additional, Danto, P., additional, Julien, S., additional, Guilhem, E., additional, Fiachetti, C., additional, Sanisidro, J., additional, Laffaye, C., additional, Gonzalez, F., additional, Pontet, B., additional, Quéruel, N., additional, Jannet, G., additional, Fergeau, P., additional, Brochot, J.-Y., additional, Cassam-Chenai, G., additional, Dudok de Wit, T., additional, Timofeeva, M., additional, Vincent, T., additional, Agrapart, C., additional, Delory, G. T., additional, Turin, P., additional, Jeandet, A., additional, Leroy, P., additional, Pellion, J.-C., additional, Bouzid, V., additional, Katra, B., additional, Piberne, R., additional, Recart, W., additional, Santolík, O., additional, Kolmašová, I., additional, Krupař, V., additional, Krupařová, O., additional, Píša, D., additional, Uhlíř, L., additional, Lán, R., additional, Baše, J., additional, Ahlèn, L., additional, André, M., additional, Bylander, L., additional, Cripps, V., additional, Cully, C., additional, Eriksson, A., additional, Jansson, S.-E., additional, Johansson, E. P. G., additional, Karlsson, T., additional, Puccio, W., additional, Břínek, J., additional, Öttacher, H., additional, Panchenko, M., additional, Berthomier, M., additional, Goetz, K., additional, Hellinger, P., additional, Horbury, T. S., additional, Issautier, K., additional, Kontar, E., additional, Krucker, S., additional, Le Contel, O., additional, Louarn, P., additional, Martinović, M., additional, Owen, C. J., additional, Retino, A., additional, Rodríguez-Pacheco, J., additional, Sahraoui, F., additional, Wimmer-Schweingruber, R. F., additional, Zaslavsky, A., additional, and Zouganelis, I., additional

Published
2021
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43. Supplemental Material, sj-docx-2-jic-10.1177_08850666211007063 - Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, Delnoij, Thijs S. R., Broman, Lars M., Lansink-Hartgring, Annemieke Oude, Hermans, Greet, De Troy, Erwin, Taccone, Fabio S., Diaz, Manuel Quintana, Van Der Velde, Franciska, Miranda, Dinis Dos Reis, Scholten, Erik, and Vlaar, Alexander P. J.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental Material, sj-docx-2-jic-10.1177_08850666211007063 for Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study by Senta Jorinde Raasveld, Thijs S. R. Delnoij, Lars M. Broman, Annemieke Oude Lansink-Hartgring, Greet Hermans, Erwin De Troy, Fabio S. Taccone, Manuel Quintana Diaz, Franciska van der Velde, Dinis Dos Reis Miranda, Erik Scholten, ETALON Study Group and Alexander P. J. Vlaar in Journal of Intensive Care Medicine

Published
2021
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44. Supplemental Material, sj-docx-1-jic-10.1177_08850666211007063 - Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study

Author

Raasveld, Senta Jorinde, Delnoij, Thijs S. R., Broman, Lars M., Lansink-Hartgring, Annemieke Oude, Hermans, Greet, De Troy, Erwin, Taccone, Fabio S., Diaz, Manuel Quintana, Van Der Velde, Franciska, Miranda, Dinis Dos Reis, Scholten, Erik, and Vlaar, Alexander P. J.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental Material, sj-docx-1-jic-10.1177_08850666211007063 for Extracorporeal Membrane Oxygenation in Patients With COVID-19: An International Multicenter Cohort Study by Senta Jorinde Raasveld, Thijs S. R. Delnoij, Lars M. Broman, Annemieke Oude Lansink-Hartgring, Greet Hermans, Erwin De Troy, Fabio S. Taccone, Manuel Quintana Diaz, Franciska van der Velde, Dinis Dos Reis Miranda, Erik Scholten, ETALON Study Group and Alexander P. J. Vlaar in Journal of Intensive Care Medicine

Published
2021
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45. Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial

Author

Spoormans, Eva M., primary, Lemkes, Jorrit S., additional, Janssens, Gladys N., additional, van der Hoeven, Nina W., additional, Jewbali, Lucia S. D., additional, Dubois, Eric A., additional, Meuwissen, Martijn, additional, Rijpstra, Tom A., additional, Bosker, Hans A., additional, Blans, Michiel J., additional, Bleeker, Gabe B., additional, Baak, Remon, additional, Vlachojannis, Georgios J., additional, Eikemans, Bob J. W., additional, Girbes, Armand R. J., additional, van der Harst, Pim, additional, van der Horst, Iwan C. C., additional, Voskuil, Michiel, additional, van der Heijden, Joris J., additional, Beishuizen, Albertus, additional, Stoel, Martin, additional, Camaro, Cyril, additional, van der Hoeven, Hans, additional, Henriques, José P., additional, Vlaar, Alexander P. J., additional, Vink, Maarten A., additional, van den Bogaard, Bas, additional, Heestermans, Ton A. C. M., additional, de Ruijter, Wouter, additional, Delnoij, Thijs S. R., additional, Crijns, Harry J. G. M., additional, Jessurun, Gillian A. J., additional, Oemrawsingh, Pranobe V., additional, Gosselink, Marcel T. M., additional, Plomp, Koos, additional, Magro, Michael, additional, van de Ven, Peter M., additional, van Royen, Niels, additional, and Elbers, Paul W. G., additional

Published
2021
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46. First observations and performance of the RPW instrument on board the Solar Orbiter mission

Author

Maksimovic, M., Soucek, J., Chust, T., Khotyaintsev, Yuri V., Kretzschmar, M., Bonnin, X., Vecchio, A., Alexandrova, O., Bale, S. D., Berard, D., Brochot, J-Y, Edberg, Niklas J. T., Eriksson, Anders, Hadid, L. Z., Johansson, Erik P. G., Karlsson, T., Katra, B., Krasnoselskikh, V, Krupar, V, Lion, S., Lorfevre, E., Matteini, L., Nguyen, Q. N., Pisa, D., Piberne, R., Plettemeier, D., Rucker, H. O., Santolik, O., Steinvall, Konrad, Steller, M., Stverak, S., Travnicek, P., Vaivads, Andris, Zaslavsky, A., Chaintreuil, S., Dekkali, M., Astier, P-A, Barbary, G., Boughedada, K., Cecconi, B., Chapron, F., Collin, C., Dias, D., Gueguen, L., Lamy, L., Leray, V, Malac-Allain, L. R., Pantellini, F., Parisot, J., Plasson, P., Thijs, S., Fratter, I, Bellouard, E., Danto, P., Julien, S., Guilhem, E., Fiachetti, C., Sanisidro, J., Laffaye, C., Gonzalez, F., Pontet, B., Queruel, N., Jannet, G., Fergeau, P., de Wit, T. Dudok, Vincent, T., Agrapart, C., Pragout, J., Bergerard-Timofeeva, M., Delory, G. T., Turin, P., Jeandet, A., Leroy, P., Pellion, J-C, Bouzid, V, Recart, W., Kolmasova, I, Kruparova, O., Uhlir, L., Lan, R., Base, J., André, Mats, Bylander, L., Cripps, Victoria, Cully, C., Jansson, S-E, Puccio, Walter, Brinek, J., Ottacher, H., Angelini, V, Berthomier, M., Evans, V, Goetz, K., Hellinger, P., Horbury, T. S., Issautier, K., Kontar, E., Le Contel, O., Louarn, P., Martinovic, M., Mueller, D., O'Brien, H., Owen, C. J., Retino, A., Rodriguez-Pacheco, J., Sahraoui, F., Sanchez, L., Walsh, A. P., Wimmer-Schweingruber, R. F., Zouganelis, I, Maksimovic, M., Soucek, J., Chust, T., Khotyaintsev, Yuri V., Kretzschmar, M., Bonnin, X., Vecchio, A., Alexandrova, O., Bale, S. D., Berard, D., Brochot, J-Y, Edberg, Niklas J. T., Eriksson, Anders, Hadid, L. Z., Johansson, Erik P. G., Karlsson, T., Katra, B., Krasnoselskikh, V, Krupar, V, Lion, S., Lorfevre, E., Matteini, L., Nguyen, Q. N., Pisa, D., Piberne, R., Plettemeier, D., Rucker, H. O., Santolik, O., Steinvall, Konrad, Steller, M., Stverak, S., Travnicek, P., Vaivads, Andris, Zaslavsky, A., Chaintreuil, S., Dekkali, M., Astier, P-A, Barbary, G., Boughedada, K., Cecconi, B., Chapron, F., Collin, C., Dias, D., Gueguen, L., Lamy, L., Leray, V, Malac-Allain, L. R., Pantellini, F., Parisot, J., Plasson, P., Thijs, S., Fratter, I, Bellouard, E., Danto, P., Julien, S., Guilhem, E., Fiachetti, C., Sanisidro, J., Laffaye, C., Gonzalez, F., Pontet, B., Queruel, N., Jannet, G., Fergeau, P., de Wit, T. Dudok, Vincent, T., Agrapart, C., Pragout, J., Bergerard-Timofeeva, M., Delory, G. T., Turin, P., Jeandet, A., Leroy, P., Pellion, J-C, Bouzid, V, Recart, W., Kolmasova, I, Kruparova, O., Uhlir, L., Lan, R., Base, J., André, Mats, Bylander, L., Cripps, Victoria, Cully, C., Jansson, S-E, Puccio, Walter, Brinek, J., Ottacher, H., Angelini, V, Berthomier, M., Evans, V, Goetz, K., Hellinger, P., Horbury, T. S., Issautier, K., Kontar, E., Le Contel, O., Louarn, P., Martinovic, M., Mueller, D., O'Brien, H., Owen, C. J., Retino, A., Rodriguez-Pacheco, J., Sahraoui, F., Sanchez, L., Walsh, A. P., Wimmer-Schweingruber, R. F., and Zouganelis, I

Abstract

The Radio and Plasma Waves (RPW) instrument on the ESA Solar Orbiter mission is designed to measure in situ magnetic and electric fields and waves from the continuum up to several hundred kHz. The RPW also observes solar and heliospheric radio emissions up to 16 MHz. It was switched on and its antennae were successfully deployed two days after the launch of Solar Orbiter on February 10, 2020. Since then, the instrument has acquired enough data to make it possible to assess its performance and the electromagnetic disturbances it experiences. In this article, we assess its scientific performance and present the first RPW observations. In particular, we focus on a statistical analysis of the first observations of interplanetary dust by the instrument's Thermal Noise Receiver. We also review the electro-magnetic disturbances that RPW suffers, especially those which potential users of the instrument data should be aware of before starting their research work.

Published
2021
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47. The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Lemkes, Jorrit S, Spoormans, Eva M, Demirkiran, Ahmet, Leutscher, Sophie, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Rémon, Vlachojannis, Georgios J, Eikemans, Bob J W, van der Harst, Pim, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, van de Ven, Peter M, van Loon, Ramon B, and van Royen, Niels

Published
2021

48. Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Author

Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, van Royen, Niels, Team Medisch, Circulatory Health, Medische Staf Intensive Care, Spoormans, Eva M, Lemkes, Jorrit S, Janssens, Gladys N, van der Hoeven, Nina W, Jewbali, Lucia S D, Dubois, Eric A, van de Ven, Peter M, Meuwissen, Martijn, Rijpstra, Tom A, Bosker, Hans A, Blans, Michiel J, Bleeker, Gabe B, Baak, Remon, Vlachojannis, Georgios J, Eikemans, Bob J W, der Harst, Pim van, van der Horst, Iwan C C, Voskuil, Michiel, van der Heijden, Joris J, Beishuizen, Albertus, Stoel, Martin, Camaro, Cyril, van der Hoeven, Hans, Henriques, José P, Vlaar, Alexander P J, Vink, Maarten A, van den Bogaard, Bas, Heestermans, Ton A C M, de Ruijter, Wouter, Delnoij, Thijs S R, Crijns, Harry J G M, Jessurun, Gillian A J, Oemrawsingh, Pranobe V, Gosselink, Marcel T M, Plomp, Koos, Magro, Michael, Elbers, Paul W G, Appelman, Yolande, and van Royen, Niels

Published
2021

49. Poster Abstracts

Author

Thijs S. Stutvoet, A.G.T. Terwisscha van Scheltinga, S de Jong, M. de Bruyn, Arjan Kol, Rudolf S N Fehrmann, and E.G.E. de Vries

Subjects
MAPK/ERK pathway, Cancer Research, Lung, Chemistry, Wild type, Ligand (biochemistry), medicine.disease, medicine.anatomical_structure, Oncology, medicine, Cancer research, Adenocarcinoma, Non small cell, Programmed death
Published
2018
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