468 results on '"Thiessen-Philbrook, Heather"'
Search Results
2. Longitudinal biomarkers and kidney disease progression after acute kidney injury.
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Wen, Yumeng, Xu, Leyuan, Melchinger, Isabel, Thiessen-Philbrook, Heather, Moledina, Dennis G, Coca, Steven G, Hsu, Chi-Yuan, Go, Alan S, Liu, Kathleen D, Siew, Edward D, Ikizler, T Alp, Chinchilli, Vernon M, Kaufman, James S, Kimmel, Paul L, Himmelfarb, Jonathan, Cantley, Lloyd G, Parikh, Chirag R, and ASSESS-AKI Consortium
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ASSESS-AKI Consortium ,Kidney ,Animals ,Mice ,Disease Progression ,Inflammation ,Prospective Studies ,Renal Insufficiency ,Chronic ,Acute Kidney Injury ,Biomarkers ,Chronic kidney disease ,Diagnostics ,Epidemiology ,Nephrology ,Prevention ,Kidney Disease ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Renal and urogenital ,Good Health and Well Being - Abstract
BACKGROUNDLongitudinal investigations of murine acute kidney injury (AKI) suggest that injury and inflammation may persist long after the initial insult. However, the evolution of these processes and their prognostic values are unknown in patients with AKI.METHODSIn a prospective cohort of 656 participants hospitalized with AKI, we measured 7 urine and 2 plasma biomarkers of kidney injury, inflammation, and tubular health at multiple time points from the diagnosis to 12 months after AKI. We used linear mixed-effect models to estimate biomarker changes over time, and we used Cox proportional hazard regressions to determine their associations with a composite outcome of chronic kidney disease (CKD) incidence and progression. We compared the gene expression kinetics of biomarkers in murine models of repair and atrophy after ischemic reperfusion injury (IRI).RESULTSAfter 4.3 years, 106 and 52 participants developed incident CKD and CKD progression, respectively. Each SD increase in the change of urine KIM-1, MCP-1, and plasma TNFR1 from baseline to 12 months was associated with 2- to 3-fold increased risk for CKD, while the increase in urine uromodulin was associated with 40% reduced risk for CKD. The trajectories of these biological processes were associated with progression to kidney atrophy in mice after IRI.CONCLUSIONSustained tissue injury and inflammation, and slower restoration of tubular health, are associated with higher risk of kidney disease progression. Further investigation into these ongoing biological processes may help researchers understand and prevent the AKI-to-CKD transition.FUNDINGNIH and NIDDK (grants U01DK082223, U01DK082185, U01DK082192, U01DK082183, R01DK098233, R01DK101507, R01DK114014, K23DK100468, R03DK111881, K01DK120783, and R01DK093771).
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- 2023
3. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies.
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Coca, Steven, Vasquez-Rios, George, Mansour, Sherry, Moledina, Dennis, Thiessen-Philbrook, Heather, Wurfel, Mark, Bhatraju, Pavan, Himmelfarb, Jonathan, Siew, Eddie, Garg, Amit, Hsu, Chi-Yuan, Kimmel, Paul, Chinchilli, Vernon, Kaufman, James, Wilson, Michelle, Banks, Rosamonde, Packington, Rebecca, McCole, Eibhlin, Kurth, Mary, Richardson, Ciaran, Go, Alan, Selby, Nicholas, Parikh, Chirag, and Liu, Kathleen
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AKI follow-up ,Acute kidney injury (AKI) ,biomarker ,end-stage kidney disease (ESKD) ,heart failure ,hospitalization ,kidney disease progression ,mortality ,prognosis ,risk stratification ,sTNFR2 ,soluble tumor necrosis factor receptor 1 (sTNFR1) ,Humans ,Prospective Studies ,Receptors ,Tumor Necrosis Factor ,Acute Kidney Injury ,Hospitalization ,Biomarkers ,Heart Failure - Abstract
RATIONALE & OBJECTIVE: The role of plasma soluble tumor necrosis factor receptor 1 (sTNFR1) and sTNFR2 in the prognosis of clinical events after hospitalization with or without acute kidney injury (AKI) is unknown. STUDY DESIGN: Prospective cohort. SETTING & PARTICIPANTS: Hospital survivors from the ASSESS-AKI (Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury) and ARID (AKI Risk in Derby) studies with and without AKI during the index hospitalization who had baseline serum samples for biomarker measurements. PREDICTORS: We measured sTNFR1 and sTNFR2 from plasma samples obtained 3 months after discharge. OUTCOMES: The associations of biomarkers with longitudinal kidney disease incidence and progression, heart failure, and death were evaluated. ANALYTICAL APPROACH: Cox proportional hazard models. RESULTS: Among 1,474 participants with plasma biomarker measurements, 19% had kidney disease progression, 14% had later heart failure, and 21% died during a median follow-up of 4.4 years. For the kidney outcome, the adjusted HRs (AHRs) per doubling in concentration were 2.9 (95% CI, 2.2-3.9) for sTNFR1 and 1.9 (95% CI, 1.5-2.5) for sTNFR2. AKI during the index hospitalization did not modify the association between biomarkers and kidney events. For heart failure, the AHRs per doubling in concentration were 1.9 (95% CI, 1.4-2.5) for sTNFR1 and 1.5 (95% CI, 1.2-2.0) for sTNFR2. For mortality, the AHRs were 3.3 (95% CI, 2.5-4.3) for sTNFR1 and 2.5 (95% CI, 2.0-3.1) for sTNFR2. The findings in ARID were qualitatively similar in terms of the magnitude of association between biomarkers and outcomes. LIMITATIONS: Different biomarker platforms and AKI definitions; limited generalizability to other ethnic groups. CONCLUSIONS: Plasma sTNFR1 and sTNFR2 measured 3 months after hospital discharge were independently associated with clinical events regardless of AKI status during the index admission. sTNFR1 and sTNFR2 may assist with the risk stratification of patients during follow-up.
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- 2023
4. Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury
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Wen, Yumeng, Thiessen-Philbrook, Heather, Moledina, Dennis G, Kaufman, James S, Reeves, W Brian, Ghahramani, Nasrollah, Ikizler, T Alp, Go, Alan S, Liu, Kathleen D, Siew, Eddie D, Himmelfarb, Jonathan, Kimmel, Paul L, Hsu, Chi-yuan, and Parikh, Chirag R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Renal and urogenital ,Good Health and Well Being ,acute kidney injury ,biomarker ,chronic kidney disease ,urine concentration ,urine creatinine ,urine osmolarity ,Biomedical and clinical sciences ,Health sciences - Abstract
IntroductionBiomarkers of acute kidney injury (AKI) are often indexed to urine creatinine (UCr) or urine osmolarity (UOsm) to control for urine concentration. We evaluated how these approaches affect the biomarker-outcome association in patients with AKI.MethodsThe Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury Study was a cohort of hospitalized patients with and without AKI between 2009 and 2015. Using Cox proportional hazards regression, we assessed the associations and predictions (C-statistics) of urine biomarkers with a composite outcome of incident chronic kidney disease (CKD) and CKD progression. We used 4 approaches to account for urine concentration: indexing and adjusting for UCr and UOsm.ResultsAmong 1538 participants, 769 (50%) had AKI and 300 (19.5%) developed composite CKD outcome at median follow-up of 4.7 years. UCr and UOsm during hospitalization were inversely associated with the composite CKD outcome. The associations and predictions with CKD were significantly strengthened after indexing or adjusting for UCr or UOsm for urine kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in patients with AKI. There was no significant improvement with indexing or adjusting UCr or UOsm for albumin, neutrophil gelatinase-associated lipocalin (NGAL), and chitinase 3-like 1 (YKL-40). Uromodulin's (UMOD) inverse association with the outcome was significantly blunted after indexing but not adjusting for UCr or UOsm.ConclusionUCr and UOsm during hospitalization are inversely associated with development and progression of CKD. Indexing or adjusting for UCr or UOsm strengthened associations and improved predictions for CKD for only some biomarkers. Incorporating urinary concentration should be individualized for each biomarker in research and clinical applications.
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- 2022
5. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
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de Fontnouvelle, Christina, Zappitelli, Michael, Thiessen-Philbrook, Heather R., Jia, Yaqi, Kimmel, Paul L., Kaufman, James S., and Devarajan, Prasad
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Heart -- Surgery ,Acute renal failure -- Risk factors -- Diagnosis ,Biological markers -- Analysis ,Health - Abstract
Background Children who require surgery for congenital heart disease have increased risk for long-term chronic kidney disease (CKD). Clinical factors as well as urine biomarkers of tubular health and injury may help improve the prognostication of estimated glomerular filtration rate (eGFR) decline. Methods We enrolled children from 1 month to 18 years old undergoing cardiac surgery in the ASSESS-AKI cohort. We used mixed-effect models to assess the association between urinary biomarkers (log2-transformed uromodulin, NGAL, KIM-1, IL-18, L-FABP) measured 3 months after cardiac surgery and cyanotic heart disease with the rate of eGFR decline at annual in-person visits over 4 years. Results Of the 117 children enrolled, 30 (24%) had cyanotic heart disease. During 48 months of follow-up, the median eGFR in the subgroup of children with cyanotic heart disease was lower at all study visits as compared with children with acyanotic heart disease (p = 0.01). In the overall cohort, lower levels of both urine uromodulin and IL-18 after discharge were associated with eGFR decline. After adjustment for age, RACHS-1 surgical complexity score, proteinuria, and eGFR at the 3-month study visit, lower concentrations of urine uromodulin and IL-18 were associated with a monthly decline in eGFR (uromodulin [beta] = 0.04 (95% CI: 0.00-0.09; p = 0.07) IL-18 [beta] = 0.07 (95% CI: 0.01-0.13; p = 0.04), ml/min/1.73 m.sup.2 per month). Conclusions At 3 months after cardiac surgery, children with lower urine uromodulin and IL-18 concentrations experienced a significantly faster decline in eGFR. Children with cyanotic heart disease had a lower median eGFR at all time points but did not experience faster eGFR decline. Graphical abstract, Author(s): Christina de Fontnouvelle [sup.1] , Michael Zappitelli [sup.2] , Heather R. Thiessen-Philbrook [sup.3] , Yaqi Jia [sup.3] , Paul L. Kimmel [sup.4] , James S. Kaufman [sup.5] , Prasad [...]
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- 2023
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6. Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients
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Liu, Richard X, Thiessen-Philbrook, Heather R, Vasan, Ramachandran S, Coresh, Josef, Ganz, Peter, Bonventre, Joseph V, Kimmel, Paul L, and Parikh, Chirag R
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Biotechnology ,Acquired Cognitive Impairment ,Brain Disorders ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Aged ,80 and over ,Aptamers ,Peptide ,Biomarkers ,Blood Chemical Analysis ,Blood Proteins ,Cardiac Surgical Procedures ,Female ,Humans ,Immunoassay ,Male ,Middle Aged ,Preoperative Period ,Proteomics ,Clinical Sciences ,General Clinical Medicine ,Biochemistry and cell biology ,Clinical sciences - Abstract
Although immunoassays are the most widely used protein measurement method, aptamer-based methods such as the SomaScan platform can quantify up to 7000 proteins per biosample, creating new opportunities for unbiased discovery. However, there is limited research comparing the consistency of biomarker-disease associations between immunoassay and aptamer-based platforms. In a substudy of the TRIBE-AKI cohort, preoperative and postoperative plasma samples from 294 patients with previous immunoassay measurements were analyzed using the SomaScan platform. Inter-platform Spearman correlations (rs) and biomarker-AKI associations were compared across 30 preoperative and 34 postoperative immunoassay-aptamer pairs. Possible factors contributing to inter-platform differences were examined including target protein characteristics, immunoassay, and SomaScan coefficients of variation, other assay characteristics, and sample storage time. The median rs was 0.54 (interquartile range [IQR] 0.34-0.83) in postoperative samples and 0.41 (IQR 0.21-0.69) in preoperative samples. We observed a trend of greater rs in biomarkers with greater concentrations; the Spearman correlation between the concentration of protein and the inter-platform correlation was 0.64 in preoperative pairs and 0.53 in postoperative pairs. Of proteins measured by immunoassays, we observed significant biomarker-AKI associations for 13 proteins preop and 24 postop; of all corresponding aptamers, 8 proteins preop and 12 postop. All proteins significantly associated with AKI as measured by SomaScan were also significantly associated with AKI as measured by immunoassay. All biomarker-AKI odds ratios were significantly different (P < 0.05) between platforms in 14% of aptamer-immunoassay pairs, none of which had high (rs > 0.50) inter-platform correlations. Although similar biomarker-disease associations were observed overall, biomarkers with high physiological concentrations tended to have the highest-confidence inter-platform operability in correlations and biomarker-disease associations. Aptamer assays provide excellent precision and an unprecedented coverage and promise for disease associations but interpretation of results should keep in mind a broad range of correlations with immunoassays.
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- 2021
7. Implementation of the Kidney Failure Risk Equation in a United States Nephrology Clinic
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Patel, Dipal M., Churilla, Bryce M., Thiessen-Philbrook, Heather, Sang, Yingying, Grams, Morgan E., Parikh, Chirag R., and Crews, Deidra C.
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- 2023
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8. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
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Menez, Steven, Wen, Yumeng, Xu, Leyuan, Moledina, Dennis G., Thiessen-Philbrook, Heather, Hu, David, Obeid, Wassim, Bhatraju, Pavan K., Ikizler, T. Alp, Siew, Edward D., Chinchilli, Vernon M., Garg, Amit X., Go, Alan S., Liu, Kathleen D., Kaufman, James S., Kimmel, Paul L., Himmelfarb, Jonathan, Coca, Steven G., Cantley, Lloyd G., and Parikh, Chirag R.
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- 2023
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9. Biomarkers of inflammation and repair in kidney disease progression
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Puthumana, Jeremy, Thiessen-Philbrook, Heather, Xu, Leyuan, Coca, Steven G, Garg, Amit X, Himmelfarb, Jonathan, Bhatraju, Pavan K, Ikizler, Talat Alp, Siew, Edward, Ware, Lorraine B, Liu, Kathleen D, Go, Alan S, Kaufman, James S, Kimmel, Paul L, Chinchilli, Vernon M, Cantley, Lloyd, and Parikh, Chirag R
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Kidney Disease ,Clinical Research ,4.2 Evaluation of markers and technologies ,2.1 Biological and endogenous factors ,Detection ,screening and diagnosis ,Aetiology ,Renal and urogenital ,Acute Kidney Injury ,Aged ,Animals ,Biomarkers ,Chemokine CCL2 ,Chitinase-3-Like Protein 1 ,Disease Models ,Animal ,Disease Progression ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Humans ,Inflammation ,Male ,Mice ,Middle Aged ,Renal Insufficiency ,Chronic ,Chronic kidney disease ,Clinical practice ,Molecular diagnosis ,Nephrology ,Medical and Health Sciences ,Immunology - Abstract
INTRODUCTIONAcute kidney injury and chronic kidney disease (CKD) are common in hospitalized patients. To inform clinical decision making, more accurate information regarding risk of long-term progression to kidney failure is required.METHODSWe enrolled 1538 hospitalized patients in a multicenter, prospective cohort study. Monocyte chemoattractant protein 1 (MCP-1/CCL2), uromodulin (UMOD), and YKL-40 (CHI3L1) were measured in urine samples collected during outpatient follow-up at 3 months. We followed patients for a median of 4.3 years and assessed the relationship between biomarker levels and changes in estimated glomerular filtration rate (eGFR) over time and the development of a composite kidney outcome (CKD incidence, CKD progression, or end-stage renal disease). We paired these clinical studies with investigations in mouse models of renal atrophy and renal repair to further understand the molecular basis of these markers in kidney disease progression.RESULTSHigher MCP-1 and YKL-40 levels were associated with greater eGFR decline and increased incidence of the composite renal outcome, whereas higher UMOD levels were associated with smaller eGFR declines and decreased incidence of the composite kidney outcome. A multimarker score increased prognostic accuracy and reclassification compared with traditional clinical variables alone. The mouse model of renal atrophy showed greater Ccl2 and Chi3l1 mRNA expression in infiltrating macrophages and neutrophils, respectively, and evidence of progressive renal fibrosis compared with the repair model. The repair model showed greater Umod expression in the loop of Henle and correspondingly less fibrosis.CONCLUSIONSBiomarker levels at 3 months after hospitalization identify patients at risk for kidney disease progression.FUNDINGNIH.
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- 2021
10. Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure
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Liu, Richard X., Koyawala, Neel, Thiessen-Philbrook, Heather R., Doshi, Mona D., Reese, Peter P., Hall, Isaac E., Mohan, Sumit, and Parikh, Chirag R.
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- 2023
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11. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
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Deng, Jie, Atta, Mo, Bagnasco, Serena M., Ko, Albert, Iwasaki, Akiko, Farhadian, Shelli, Nelson, Allison, Casanovas-Massana, Arnau, White, Elizabeth B., Schulz, Wade, Coppi, Andreas, Young, Patrick, Nunez, Angela, Shepard, Denise, Matos, Irene, Strong, Yvette, Anastasio, Kelly, Brower, Kristina, Kuang, Maxine, Chiorazzi, Michael, Bermejo, Santos, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Minasyan, Maksym, Muenker, M. Catherine, Moore, Adam J., Nadkarni, Girish, Menez, Steven, Coca, Steven G., Moledina, Dennis G., Wen, Yumeng, Chan, Lili, Thiessen-Philbrook, Heather, Obeid, Wassim, Garibaldi, Brian T., Azeloglu, Evren U., Ugwuowo, Ugochukwu, Sperati, C. John, Arend, Lois J., Rosenberg, Avi Z., Kaushal, Madhurima, Jain, Sanjay, Wilson, F. Perry, and Parikh, Chirag R.
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- 2023
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12. Association of Blood Mitochondrial DNA Copy Number With Risk of Acute Kidney Injury After Cardiac Surgery
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Jotwani, Vasantha, primary, Thiessen-Philbrook, Heather, additional, Arking, Dan E., additional, Yang, Stephanie Y., additional, McArthur, Eric, additional, Garg, Amit X., additional, Katz, Ronit, additional, Tranah, Gregory J., additional, Ix, Joachim H., additional, Cummings, Steve, additional, Waikar, Sushrut S., additional, Sarnak, Mark J., additional, Shlipak, Michael G., additional, Parikh, Samir M., additional, and Parikh, Chirag R., additional
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- 2024
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13. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery
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Mansour, Sherry G, Zhang, William R, Moledina, Dennis G, Coca, Steven G, Jia, Yaqi, Thiessen-Philbrook, Heather, McArthur, Eric, Inoue, Kazunori, Koyner, Jay L, Shlipak, Michael G, Wilson, F Perry, Garg, Amit X, Ishibe, Shuta, Parikh, Chirag R, and Consortium, TRIBE-AKI
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Clinical Research ,Kidney Disease ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Biomarkers ,Cardiac Surgical Procedures ,Creatinine ,Endpoint Determination ,Female ,Humans ,Kidney ,Male ,Middle Aged ,Neovascularization ,Physiologic ,Outcome Assessment ,Health Care ,Postoperative Complications ,Prospective Studies ,Receptors ,Vascular Endothelial Growth Factor ,Risk Assessment ,United States ,Vascular Endothelial Growth Factor A ,TRIBE-AKI Consortium ,AKI duration ,Acute kidney injury ,VEGF-A ,angiogenesis ,angiogenic growth factor ,biomarker ,cardiac surgery ,cytokine ,mortality ,placental growth factor ,soluble VEGF receptor 1 ,vascular endothelial growth factor A ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
Rationale & objectiveThe process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.Study designProspective cohort.Setting & participants1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.ExposuresPlasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.OutcomesAKI, long AKI duration (≥7 days), and 1-year all-cause mortality.Analytical approachMultivariable logistic regression.ResultsFollowing cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).LimitationsAngiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.ConclusionsHigher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.
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- 2019
14. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
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Vasquez-Rios, George, Moledina, Dennis G., Jia, Yaqi, McArthur, Eric, Mansour, Sherry G., Thiessen-Philbrook, Heather, Shlipak, Michael G., Koyner, Jay L., Garg, Amit X., Parikh, Chirag R., and Coca, Steven G.
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- 2022
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15. Trends in the procurement and discard of kidneys from deceased donors with acute kidney injury
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Liu, Caroline, Alasfar, Sami, Reese, Peter P., Mohan, Sumit, Doshi, Mona D., Hall, Isaac E., Thiessen Philbrook, Heather, Jia, Yaqi, Stewart, Darren, and Parikh, Chirag R.
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- 2022
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16. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis.
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Wen, Yumeng, Mansour, Sherry G., Srialluri, Nityasree, Hu, David, Thiessen Philbrook, Heather, Hall, Isaac E., Doshi, Mona D., Mohan, Sumit, Reese, Peter P., and Parikh, Chirag R.
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KIDNEY transplantation ,TREATMENT effectiveness ,DEAD ,DIALYSIS (Chemistry) ,HEMODIALYSIS - Abstract
Key Points: Question: Are kidneys from deceased donors who underwent dialysis prior to kidney donation associated with adverse graft outcomes in kidney transplant recipients compared with kidneys from deceased donors who did not undergo dialysis? Findings: In an analysis of 1944 kidney transplant recipients (including 954 who received kidneys from deceased donors who underwent dialysis prior to kidney donation), the incidence of delayed graft function was higher in recipients of kidneys from deceased donors who underwent dialysis prior to kidney donation vs recipients of kidneys from deceased donors who did not undergo dialysis (59.2% vs 24.6%, respectively), but there were no significant differences in the incidence of graft failure (adjusted odds ratio, 0.90) or mortality (adjusted hazard ratio, 0.76) at a median follow-up of 34.1 months. Meaning: Compared with recipients of kidneys from deceased donors who did not undergo dialysis, receiving kidneys from deceased donors who underwent dialysis prior to donation was associated with a higher incidence of delayed graft function, but no difference in graft failure or death at longer-term follow-up. Importance: Recipient outcomes after kidney transplant from deceased donors who received dialysis prior to kidney donation are not well described. Objective: To compare outcomes of transplant recipients who received kidneys from deceased donors who underwent dialysis prior to kidney donation vs recipients of kidneys from deceased donors who did not undergo dialysis. Design, Setting, and Participants: A retrospective cohort study was conducted including data from 58 US organ procurement organizations on deceased kidney donors and kidney transplant recipients. From 2010 to 2018, 805 donors who underwent dialysis prior to kidney donation were identified. The donors who underwent dialysis prior to kidney donation were matched 1:1 with donors who did not undergo dialysis using a rank-based distance matrix algorithm; 1944 kidney transplant recipients were evaluated. Exposure: Kidney transplants from deceased donors who underwent dialysis prior to kidney donation compared with kidney transplants from deceased donors who did not undergo dialysis. Main Outcomes and Measures: The 4 study outcomes were delayed graft function (defined as receipt of dialysis by the kidney recipient ≤1 week after transplant), all-cause graft failure, death-censored graft failure, and death. Results: From 2010 to 2018, 1.4% of deceased kidney donors (805 of 58 155) underwent dialysis prior to kidney donation. Of these 805 individuals, 523 (65%) donated at least 1 kidney. A total of 969 kidneys (60%) were transplanted and 641 kidneys (40%) were discarded. Among the donors with kidneys transplanted, 514 (mean age, 33 years [SD, 10.8 years]; 98 had hypertension [19.1%] and 36 had diabetes [7%]) underwent dialysis prior to donation and were matched with 514 (mean age, 33 years [SD, 10.9 years]; 98 had hypertension [19.1%] and 36 had diabetes [7%]) who did not undergo dialysis. Kidney transplants from donors who received dialysis prior to donation (n = 954 kidney recipients) were associated with a higher risk of delayed graft function compared with kidney transplants from donors who did not receive dialysis (n = 990 kidney recipients) (59.2% vs 24.6%, respectively; adjusted odds ratio, 4.17 [95% CI, 3.28-5.29]). The incidence rates did not significantly differ at a median follow-up of 34.1 months for all-cause graft failure (43.1 kidney transplants per 1000 person-years from donors who received dialysis prior to donation vs 46.9 kidney transplants per 1000 person-years from donors who did not receive dialysis; adjusted hazard ratio [HR], 0.90 [95% CI, 0.70-1.15]), for death-censored graft failure (22.5 vs 20.6 per 1000 person-years, respectively; adjusted HR, 1.18 [95% CI, 0.83-1.69]), or for death (24.6 vs 30.8 per 1000 person-years; adjusted HR, 0.76 [95% CI, 0.55-1.04]). Conclusions and Relevance: Compared with receiving a kidney from a deceased donor who did not undergo dialysis, receiving a kidney from a deceased donor who underwent dialysis prior to kidney donation was associated with a significantly higher incidence of delayed graft function, but no significant difference in graft failure or death at follow-up. This study compares the outcomes of kidney transplant recipients who received kidneys from deceased donors who underwent dialysis prior to kidney donation vs recipients of kidneys from deceased donors who did not undergo dialysis. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients
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Liu, Richard X., Thiessen-Philbrook, Heather R., Vasan, Ramachandran S., Coresh, Josef, Ganz, Peter, Bonventre, Joseph V., Kimmel, Paul L., and Parikh, Chirag R.
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- 2021
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18. The authors reply
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Hu, David, primary, Menez, Steve, additional, Thiessen-Philbrook, Heather, additional, and Parikh, Chirag R., additional
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- 2024
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19. 24-hour ambulatory blood pressure monitoring 9 years after pediatric cardiac surgery: a pilot and feasibility study
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Fredric, Daniel, Greenberg, Jason H., Parikh, Chirag R., Devarajan, Prasad, Chui, Hayton, Cockovski, Vedran, Pizzi, Michael, Palijan, Ana, Hessey, Erin, Jia, Yaqi, Thiessen-Philbrook, Heather R., and Zappitelli, Michael
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Heart -- Surgery ,Children -- Surgery ,Blood pressure -- Measurement ,Postoperative care -- Methods ,Health - Abstract
Background Children undergoing cardiac surgery are at risk of high blood pressure (BP), a risk factor for cardiovascular and kidney disease. Twenty-four-hour ambulatory BP monitoring (ABPM) is a reference standard hypertension (HTN) test. Little data exist on ABPM abnormalities in children several years post cardiac surgery. This study aimed to (a) determine ABPM feasibility; (b) describe and compare ABPM measures and abnormalities (percent load, masked HTN [MH]; non-dipping, mean systolic/diastolic BP > 95th percentile; pre-HTN (ABPM); white-coat HTN [WCH]) to casual BP; and (c) compare BP in patients with and without acute kidney injury (AKI). Methods Prospective, follow-up pilot study of children (0-18 years) who underwent cardiac surgery from 2007 to 2009 at Montreal Children's Hospital. We recorded if participants had post-operative AKI and assessed the following outcomes at 9-year follow-up: casual BP classified by three single-visit measures (normal; elevated BP [eBP.sub.SingleVisit]; HTN.sub.SingleVisit); ABPM. Bivariable analyses were used to compare characteristics between groups. Results Twenty-three patients (median [interquartile range], 8.6 [8.0, 9.0] years post cardiac surgery) were included; 16 (70%) male. Six participants (26%) had eBP.sub.SingleVisit or higher. On ABPM, 11 (48%) had [greater than or equal to] 1 abnormality: 9 (39%) had non-dipping; 3 (13%) had pre-HTN; 3 (13%) had WCH; none had HTN or MH. There were no differences in ABPM according to AKI status. Conclusion Our pilot study determined that ABPM was feasible in children years after cardiac surgery and frequently identified ABPM abnormalities. Future research in larger populations is needed to define specific risk factors for HTN in children after cardiac surgery., Author(s): Daniel Fredric [sup.1] , Jason H. Greenberg [sup.2] , Chirag R. Parikh [sup.3] , Prasad Devarajan [sup.4] , Hayton Chui [sup.1] , Vedran Cockovski [sup.1] , Michael Pizzi [sup.5] [...]
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- 2021
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20. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery
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Menez, Steven, Moledina, Dennis G., Garg, Amit X., Thiessen-Philbrook, Heather, McArthur, Eric, Jia, Yaqi, Liu, Caroline, Obeid, Wassim, Mansour, Sherry G., Koyner, Jay L., Shlipak, Michael G., Wilson, Francis P., Coca, Steven G., and Parikh, Chirag R.
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- 2021
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21. Use of urine biomarker-derived clusters to predict the risk of chronic kidney disease and all-cause mortality in HIV-infected women
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Scherzer, Rebecca, Lin, Haiqun, Abraham, Alison, Thiessen-Philbrook, Heather, Parikh, Chirag R, Bennett, Michael, Cohen, Mardge H, Nowicki, Marek, Gustafson, Deborah R, Sharma, Anjali, Young, Mary, Tien, Phyllis, Jotwani, Vasantha, and Shlipak, Michael G
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Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Kidney Disease ,Prevention ,Sexually Transmitted Infections ,HIV/AIDS ,Clinical Research ,Infection ,Renal and urogenital ,Good Health and Well Being ,Acetylglucosaminidase ,Adult ,Alpha-Globulins ,Biomarkers ,Creatinine ,Cystatin C ,Fatty Acid-Binding Proteins ,Female ,HIV Infections ,HIV-1 ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Interleukin-18 ,Lipocalin-2 ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Renal Insufficiency ,Chronic ,Risk Factors ,biomarker ,chronic kidney disease ,cluster analysis ,HIV ,risk discrimination ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundAlthough individual urine biomarkers are associated with chronic kidney disease (CKD) incidence and all-cause mortality in the setting of HIV infection, their combined utility for prediction remains unknown.MethodsWe measured eight urine biomarkers shown previously to be associated with incident CKD and mortality risk among 902 HIV-infected women in the Women's Interagency HIV Study: N-acetyl-β-d-glucosaminidase (NAG), kidney injury molecule-1 (KIM-1), alpha-1 microglobulin (α1m), interleukin 18, neutrophil gelatinase-associated lipocalin, albumin-to-creatinine ratio, liver fatty acid-binding protein and α-1-acid-glycoprotein. A group-based cluster method classified participants into three distinct clusters using the three most distinguishing biomarkers (NAG, KIM-1 and α1m), independent of the study outcomes. We then evaluated associations of each cluster with incident CKD (estimated glomerular filtration rate
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- 2016
22. Association of Peak Changes in Plasma Cystatin C and Creatinine With Death After Cardiac Operations
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Park, Meyeon, Shlipak, Michael G, Thiessen-Philbrook, Heather, Garg, Amit X, Koyner, Jay L, Coca, Steven G, Parikh, Chirag R, and Consortium, Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury
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Kidney Disease ,Heart Disease ,Cardiovascular ,Clinical Research ,Renal and urogenital ,Acute Kidney Injury ,Adult ,Aged ,Aged ,80 and over ,Biomarkers ,Cardiac Surgical Procedures ,Creatinine ,Cystatin C ,Female ,Hospitalization ,Humans ,Longitudinal Studies ,Male ,Middle Aged ,Time Factors ,Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury Consortium ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Respiratory System - Abstract
BackgroundAcute kidney injury is a risk factor for death in cardiac surgical patients. Plasma cystatin C and creatinine have different temporal profiles in the postoperative setting, but the associations of simultaneous changes in both filtration markers compared with change in only one marker with prognosis after hospital discharge are not well described.MethodsThis is a longitudinal study of 1,199 high-risk adult cardiac surgical patients in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) Consortium who survived hospitalization. We examined in-hospital peak changes of cystatin C and creatinine in the 3 days after cardiac operations. We evaluated associations of these filtration markers with death, adjusting for demographics, operative characteristics, medical comorbidities, preoperative estimated glomerular filtration rate, preoperative urinary albumin-to-creatinine ratio, and site.ResultsDuring the first 3 days of hospitalization, nearly twice as many patients had a 25% or higher rise in creatinine (30%) compared with a 25% or higher peak rise in cystatin C (15%). The risk of death was higher in those with elevations in cystatin C (adjusted hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.4 to 2.37) or creatinine (adjusted HR, 1.90; 95% CI, 1.32 to 2.72) compared with patients who experienced a postoperative decrease in either filtration marker. Patients who had simultaneous elevations of 25% or higher in cystatin C and creatinine were at similar adjusted risk for 3-year mortality (HR, 1.79; 95% CI, 1.03 to 3.1) as those with a 25% or higher increase in cystatin C alone (HR, 2.2; 95% CI, 1.09 to 4.47).ConclusionsElevations in creatinine postoperatively are more common than elevations in cystatin C. However, elevations in cystatin C appeared to be associated with a higher risk of death after hospital discharge.
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- 2016
23. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR
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Koyner, Jay L, Coca, Steven G, Thiessen-Philbrook, Heather, Patel, Uptal D, Shlipak, Michael G, Garg, Amit X, Parikh, Chirag R, Consortium, Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury, Raman, Jai, Jeevanandam, Valluvan, Akhter, Shahab, Devarajan, Prasad, Bennett, Michael, Ma, Qing, Griffiths, Rachel, Edelstein, Charles, Passik, Cary, Nagy, Judy, Swaminathan, Madhav, Chu, Michael, Goldbach, Martin, Guo, Lin Ruo, McKenzie, Neil, Myers, Mary Lee, Novick, Richard, Quantz, Mac, Schumann, Virginia, Webster, Laura, Zappitelli, Michael, Palijan, Ana, Dewar, Michael, Darr, Umer, Hashim, Sabet, Elefteriades, John, Geirsson, Arnar, Garwood, Susan, Kemp, Rowena, and Butrymowicz, Isabel
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,Renal and urogenital ,Acute Kidney Injury ,Aged ,Aged ,80 and over ,Biomarkers ,Cardiac Surgical Procedures ,Cohort Studies ,Creatinine ,Cystatin C ,Female ,Glomerular Filtration Rate ,Humans ,Male ,Middle Aged ,Postoperative Complications ,Prospective Studies ,Urine biomarkers ,interleukin 18 ,liver-type fatty acid binding protein ,acute renal failure ,acute kidney injury ,perioperative AKI ,effect modification ,estimated glomerular filtration rate ,prognosis ,cardiac surgery ,surgical complication ,Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium ,Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury TRIBE-AKI Consortium ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundThe interaction between baseline kidney function and the performance of biomarkers of acute kidney injury (AKI) on the development of AKI is unclear.Study designPost hoc analysis of prospective cohort study.Setting & participantsThe 1,219 TRIBE-AKI Consortium adult cardiac surgery cohort participants.PredictorUnadjusted postoperative urinary biomarkers of AKI measured within 6 hours of surgery.OutcomeAKI was defined as AKI Network stage 1 (any AKI) or higher, as well as a doubling of serum creatinine level from the preoperative value or the need for post-operative dialysis (severe AKI).MeasurementsStratified analyses by preoperative estimated glomerular filtration rate (eGFR) ≤ 60 versus > 60mL/min/1.73m(2).Results180 (42%) patients with preoperative eGFRs≤60mL/min/1.73m(2) developed clinical AKI compared with 246 (31%) of those with eGFRs>60mL/min/1.73m(2) (P
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- 2015
24. Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation
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Alasfar, Sami, Hall, Isaac E., Mansour, Sherry G., Jia, Yaqi, Thiessen-Philbrook, Heather R., Weng, Francis L., Singh, Pooja, Schröppel, Bernd, Muthukumar, Thangamani, Mohan, Sumit, Malik, Rubab F., Harhay, Meera N., Doshi, Mona D., Akalin, Enver, Bromberg, Jonathan S., Brennan, Daniel C., Reese, Peter P., and Parikh, Chirag R.
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- 2021
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25. Association Between Preoperative Statin Use and Acute Kidney Injury Biomarkers in Cardiac Surgical Procedures
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Molnar, Amber O, Parikh, Chirag R, Coca, Steven G, Thiessen-Philbrook, Heather, Koyner, Jay L, Shlipak, Michael G, Myers, Mary Lee, Garg, Amit X, and Consortium, TRIBE-AKI
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Clinical Research ,Kidney Disease ,Cardiovascular ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Acute-Phase Proteins ,Adult ,Aged ,Biomarkers ,Cardiac Surgical Procedures ,Cohort Studies ,Female ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Interleukin-18 ,Lipocalin-2 ,Lipocalins ,Male ,Membrane Glycoproteins ,Middle Aged ,Prospective Studies ,Proto-Oncogene Proteins ,Receptors ,Virus ,TRIBE-AKI Consortium ,Cardiorespiratory Medicine and Haematology ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundAcute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature.MethodsWe conducted a multicenter prospective cohort study of 625 adult patients undergoing elective cardiac operations. All patients were taking statins and were grouped according to whether statins were continued or held in the 24 hours before operation. The primary outcome was AKI as defined by a doubling of serum creatinine or dialysis. The secondary outcome was the peak level of several kidney injury biomarkers. The results were adjusted for demographic and clinical factors.ResultsContinuing (vs holding) a statin before operation was not associated with a lower risk of AKI, as defined by a doubling of serum creatinine or dialysis (adjusted relative risk [RR] 1.09; 95% confidence interval [CI] 0.44, 2.70). However, continuing a statin was associated with a lower risk of elevation of the following AKI biomarkers: urine interleukin-18, urine neutrophil gelatinase-associated lipocalin, urine kidney injury molecule-1, and plasma neutrophil gelatinase-associated lipocalin (adjusted RR 0.34; 95% CI 0.18, 0.62), (adjusted RR 0.41; 95% CI 0.22, 0.76), (adjusted RR 0.37; 95% CI 0.20, 0.76), (adjusted RR 0.62; 95% CI 0.39, 0.98), respectively.ConclusionsStatins may prevent kidney injury after cardiac operations, as evidenced by lower levels of kidney injury biomarkers.
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- 2014
26. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
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Menez, Steven, primary, Coca, Steven G., additional, Moledina, Dennis G., additional, Wen, Yumeng, additional, Chan, Lili, additional, Thiessen-Philbrook, Heather, additional, Obeid, Wassim, additional, Garibaldi, Brian T., additional, Azeloglu, Evren U., additional, Ugwuowo, Ugochukwu, additional, Sperati, C. John, additional, Arend, Lois J., additional, Rosenberg, Avi Z., additional, Kaushal, Madhurima, additional, Jain, Sanjay, additional, Wilson, F. Perry, additional, Parikh, Chirag R., additional, Deng, Jie, additional, Atta, Mo, additional, Bagnasco, Serena M., additional, Ko, Albert, additional, Iwasaki, Akiko, additional, Farhadian, Shelli, additional, Nelson, Allison, additional, Casanovas-Massana, Arnau, additional, White, Elizabeth B., additional, Schulz, Wade, additional, Coppi, Andreas, additional, Young, Patrick, additional, Nunez, Angela, additional, Shepard, Denise, additional, Matos, Irene, additional, Strong, Yvette, additional, Anastasio, Kelly, additional, Brower, Kristina, additional, Kuang, Maxine, additional, Chiorazzi, Michael, additional, Bermejo, Santos, additional, Vijayakumar, Pavithra, additional, Geng, Bertie, additional, Fournier, John, additional, Minasyan, Maksym, additional, Muenker, M. Catherine, additional, Moore, Adam J., additional, and Nadkarni, Girish, additional
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- 2023
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27. Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes
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Mansour, Sherry G., Liu, Caroline, Jia, Yaqi, Reese, Peter P., Hall, Isaac E., El-Achkar, Tarek M., LaFavers, Kaice A., Obeid, Wassim, Rosenberg, Avi Z., Daneshpajouhnejad, Parnaz, Doshi, Mona D., Akalin, Enver, Bromberg, Jonathan S., Harhay, Meera N., Mohan, Sumit, Muthukumar, Thangamani, Schröppel, Bernd, Singh, Pooja, El-Khoury, Joe M., Weng, Francis L., Thiessen-Philbrook, Heather R., and Parikh, Chirag R.
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- 2020
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28. Urinary Cystatin C and Acute Kidney Injury After Cardiac Surgery
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Koyner, Jay L, Garg, Amit X, Shlipak, Michael G, Patel, Uptal D, Sint, Kyaw, Hong, Kwangik, Devarajan, Prasad, Edelstein, Charles L, Zappitelli, Michael, Thiessen-Philbrook, Heather, Parikh, Chirag R, and Consortium, Translational Research Investigating Biomarker Endpoints in AKI
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Biomedical and Clinical Sciences ,Clinical Sciences ,Patient Safety ,Kidney Disease ,Cardiovascular ,Pediatric ,Heart Disease ,Clinical Research ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Renal and urogenital ,Acute Kidney Injury ,Adolescent ,Adult ,Aged ,Biomarkers ,Cardiac Surgical Procedures ,Child ,Child ,Preschool ,Creatinine ,Cystatin C ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Heart Diseases ,Humans ,Kidney Function Tests ,Male ,Middle Aged ,Postoperative Complications ,Prognosis ,Prospective Studies ,Risk Factors ,Young Adult ,Acute kidney injury biomarkers ,cystatin C ,dialysis ,perioperative ,Translational Research Investigating Biomarker Endpoints in AKI (TRIBE AKI) Consortium ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundAcute kidney injury (AKI) is common after cardiac surgery and is associated with adverse patient outcomes. Urinary cystatin C (CysC) level is a biomarker of proximal tubule function and may increase earlier in AKI than serum creatinine level.Study designProspective cohort study.Settings & participantsThe TRIBE AKI (Translational Research Investigating Biomarker Endpoints in AKI) Consortium prospectively enrolled 1,203 adults and 299 children and adolescents at 8 institutions in 2007-2009.Index testUrinary CysC (in milligrams per liter) within the first 12 hours after surgery.OutcomeSerum creatinine-based AKI was defined as AKI Network stage 1 (mild AKI) and doubling of serum creatinine from the preoperative value or need for dialysis during hospitalization (severe AKI).Other measurementsAnalyses were adjusted for characteristics used clinically for AKI risk stratification, including age, sex, race, estimated glomerular filtration rate, diabetes, hypertension, heart failure, nonelective surgery, cardiac catheterization within 72 hours, type of surgery, myocardial infarction, and cardiopulmonary bypass time longer than 120 minutes.ResultsUrinary CysC level measured in the early postoperative period (0-6 and 6-12 hours postoperatively) correlated with both mild and severe AKI in adults and children. However, after analyses were adjusted for other factors, the effect was attenuated for both forms of AKI in both cohorts.LimitationsLimited numbers of patients with severe AKI and in-hospital dialysis treatment.ConclusionsUrinary CysC values are not associated significantly with the development of AKI after cardiac surgery in adults and children.
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- 2013
29. Serum Cystatin C– Versus Creatinine-Based Definitions of Acute Kidney Injury Following Cardiac Surgery: A Prospective Cohort Study
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Spahillari, Aferdita, Parikh, Chirag R, Sint, Kyaw, Koyner, Jay L, Patel, Uptal D, Edelstein, Charles L, Passik, Cary S, Thiessen-Philbrook, Heather, Swaminathan, Madhav, Shlipak, Michael G, and Consortium, TRIBE-AKI
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Clinical Research ,Prevention ,Kidney Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Aged ,80 and over ,Biomarkers ,Cardiac Surgical Procedures ,Cohort Studies ,Creatinine ,Cystatin C ,Female ,Hospital Mortality ,Humans ,Male ,Middle Aged ,Postoperative Complications ,Prospective Studies ,Risk Factors ,Perioperative ,acute renal failure ,diagnosis ,creatinine ,TRIBE-AKI Consortium ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundThe primary aim of this study was to compare the sensitivity and rapidity of acute kidney injury (AKI) detection by cystatin C level relative to creatinine level after cardiac surgery.Study designProspective cohort study.Settings & participants1,150 high-risk adult cardiac surgery patients in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) Consortium.PredictorChanges in serum creatinine and cystatin C levels.OutcomePostsurgical incidence of AKI.MeasurementsSerum creatinine and cystatin C were measured at the preoperative visit and daily on postoperative days 1-5. To allow comparisons between changes in creatinine and cystatin C levels, AKI end points were defined by the relative increases in each marker from baseline (25%, 50%, and 100%) and the incidence of AKI was compared based on each marker. Secondary aims were to compare clinical outcomes among patients defined as having AKI by cystatin C and/or creatinine levels.ResultsOverall, serum creatinine level detected more cases of AKI than cystatin C level: 35% developed a ≥25% increase in serum creatinine level, whereas only 23% had a ≥25% increase in cystatin C level (P < 0.001). Creatinine level also had higher proportions meeting the 50% (14% and 8%; P < 0.001) and 100% (4% and 2%; P = 0.005) thresholds for AKI diagnosis. Clinical outcomes generally were not statistically different for AKI cases detected by creatinine or cystatin C level. However, for each AKI threshold, patients with AKI confirmed by both markers had a significantly higher risk of the combined mortality/dialysis outcome compared with patients with AKI detected by creatinine level alone (P = 0.002).LimitationsThere were few adverse clinical outcomes, limiting our ability to detect differences in outcomes between subgroups of patients based on their definitions of AKI.ConclusionsIn this large multicenter study, we found that cystatin C level was less sensitive for AKI detection than creatinine level. However, confirmation by cystatin C level appeared to identify a subset of patients with AKI with a substantially higher risk of adverse outcomes.
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- 2012
30. Urine Injury Biomarkers Are Not Associated With Kidney Transplant Failure
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Koyawala, Neel, Reese, Peter P., Hall, Isaac E., Jia, Yaqi, Thiessen-Philbrook, Heather R., Mansour, Sherry G., Doshi, Mona D., Akalin, Enver, Bromberg, Jonathan S., Harhay, Meera N., Mohan, Sumit, Muthukumar, Thangamani, Schröppel, Bernd, Singh, Pooja, Weng, Francis L., and Parikh, Chirag R.
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- 2020
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31. Kidney injury biomarkers 5 years after AKI due to pediatric cardiac surgery
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Greenberg, Jason H., Devarajan, Prasad, Thiessen-Philbrook, Heather R., Krawczeski, Catherine, Parikh, Chirag R., and Zappitelli, Michael
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Heart surgery -- Complications and side effects ,Acute kidney failure -- Risk factors -- Patient outcomes ,Kidney diseases -- Risk factors -- Patient outcomes ,Biological markers -- Analysis ,Health - Abstract
Background We previously reported that children undergoing cardiac surgery are at high risk for long-term chronic kidney disease (CKD) and hypertension, although postoperative acute kidney injury (AKI) is not a risk factor for worse long-term kidney outcomes. We report here our evaluation of renal injury biomarkers 5 years after cardiac surgery to determine whether they are associated with postoperative AKI or long-term CKD and hypertension. Methods Children aged 1 month to 18 years old undergoing cardiopulmonary bypass were recruited to this prospective cohort study. At 5 years after cardiac surgery, we measured urine interleukin-18, kidney injury molecule-1, monocyte chemoattractant protein-1, YKL-40, and neutrophil gelatinase-associated lipocalin (NGAL). Biomarker levels were compared between patients with AKI and those without. We also performed a cross-sectional analysis of the association between these biomarkers with CKD and hypertension. Results Of the 305 subjects who survived hospitalization, four (1.3%) died after discharge, and 110 (36%) participated in the 5-year follow-up. Of these 110 patients, 49 (45%) had AKI. Patients with versus those without postoperative AKI did not have significantly different biomarker concentrations at 5 years after cardiac surgery. None of the biomarker concentrations were associated with CKD or hypertension at 5 years of follow-up, although CKD and hypertension were associated with a higher proportion of participants with abnormal NGAL levels. Conclusions Postoperative pediatric AKI is not associated with urinary kidney injury biomarkers 5 years after surgery. This may represent a lack of chronic renal injury after AKI, imprecise estimation of the glomerular filtration rate, the need for longer follow-up to detect chronic renal damage, or that our studied biomarkers are inadequate for evaluating subclinical chronic renal injury., Author(s): Jason H. Greenberg [sup.1] [sup.2] , Prasad Devarajan [sup.3] , Heather R. Thiessen-Philbrook [sup.2] , Catherine Krawczeski [sup.4] , Chirag R. Parikh [sup.2] [sup.5] [sup.6] , Michael Zappitelli [sup.7] [...]
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- 2018
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32. Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial
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Garg, Amit X., Devereaux, P.J., Hill, Andrew, Sood, Manish, Aggarwal, Bharat, Dubois, Luc, Hiremath, Swapnil, Guzman, Randolph, Iyer, Vikram, James, Matthew, McArthur, Eric, Moist, Louise, Ouellet, George, Parikh, Chirag R., Schumann, Virginia, Sharan, Sumit, Thiessen-Philbrook, Heather, Tobe, Sheldon, Wald, Ron, Walsh, Michael, Weir, Matthew, and Pannu, Neesh
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Curcumin -- Health aspects ,Aneurysmectomy -- Methods -- Patient outcomes ,Abdominal aortic aneurysm -- Development and progression -- Care and treatment ,Health - Abstract
BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 biomarkers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma W-terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein). RESULTS: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9). INTERPRETATION: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media. Trial registration: ClinicalTrials.gov, no. NCT01225094., Many modern medicines come from plants. (1,2) Turmeric, a plant in the ginger family that is native to South Asia, has been used for centuries as a spice and traditional [...]
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- 2018
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33. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort
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Reese, Peter P., primary, Doshi, Mona D., additional, Hall, Isaac E., additional, Besharatian, Behdad, additional, Bromberg, Jonathan S., additional, Thiessen-Philbrook, Heather, additional, Jia, Yaqi, additional, Kamoun, Malek, additional, Mansour, Sherry G., additional, Akalin, Enver, additional, Harhay, Meera N., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Schröppel, Bernd, additional, Singh, Pooja, additional, Weng, Francis L., additional, and Parikh, Chirag R., additional
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- 2023
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34. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes
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Chen, Teresa K, primary, Coca, Steven G., additional, Thiessen-Philbrook, Heather R, additional, Heerspink, Hiddo J.L., additional, Obeid, Wassim, additional, Ix, Joachim, additional, Fried, Linda, additional, Bonventre, Joseph V, additional, El-Khoury, Joe M, additional, Shlipak, Michael G., additional, and Parikh, Chirag R., additional
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- 2023
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35. Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study
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Devarajan, Prasad, Edelstein, Charles, Passik, Cary, Swaminathan, Madhav, Patel, Uptal, Zappitelli, Michael, Butrymowicz, Isabel, Belley-Côté, Emilie P., Parikh, Chirag R., Shortt, Colleen R., Coca, Steven G., Garg, Amit X., Eikelboom, John W., Kavsak, Peter, McArthur, Eric, Thiessen-Philbrook, Heather, and Whitlock, Richard P.
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- 2016
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36. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR
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Raman, Jai, Jeevanandam, Valluvan, Akhter, Shahab, Devarajan, Prasad, Bennett, Michael, Ma, Qing, Griffiths, Rachel, Edelstein, Charles, Passik, Cary, Nagy, Judy, Swaminathan, Madhav, Chu, Michael, Goldbach, Martin, Guo, Lin Ruo, McKenzie, Neil, Myers, Mary Lee, Novick, Richard, Quantz, Mac, Schumann, Virginia, Webster, Laura, Zappitelli, Michael, Palijan, Ana, Dewar, Michael, Darr, Umer, Hashim, Sabet, Elefteriades, John, Geirsson, Arnar, Garwood, Susan, Kemp, Rowena, Butrymowicz, Isabel, Koyner, Jay L., Coca, Steven G., Thiessen-Philbrook, Heather, Patel, Uptal D., Shlipak, Michael G., Garg, Amit X., and Parikh, Chirag R.
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- 2015
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37. Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure
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Liu, Richard X., primary, Koyawala, Neel, additional, Thiessen-Philbrook, Heather R., additional, Doshi, Mona D., additional, Reese, Peter P., additional, Hall, Isaac E., additional, Mohan, Sumit, additional, and Parikh, Chirag R., additional
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- 2022
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38. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
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Qian, Long, primary, Menez, Steven, additional, Hu, David, additional, Weinstein, Jason, additional, Melchinger, Hannah, additional, Thiessen-Philbrook, Heather, additional, Luciano, Randy L., additional, Turner, Jeffrey M., additional, Perazella, Mark A., additional, Corona Villalobos, Celia Pamela, additional, Shaw, Melissa M., additional, Wilson, F. Perry, additional, Parikh, Chirag R., additional, and Moledina, Dennis G., additional
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- 2022
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39. Procurement Biopsy Findings Versus Kidney Donor Risk Index for Predicting Renal Allograft Survival
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Hall, Isaac E., Parikh, Chirag R., Schröppel, Bernd, Weng, Francis L., Jia, Yaqi, Thiessen-Philbrook, Heather, Reese, Peter P., and Doshi, Mona D.
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- 2018
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40. Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D
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Chen, Teresa K., primary, Coca, Steven G., additional, Estrella, Michelle M., additional, Appel, Lawrence J., additional, Coresh, Josef, additional, Thiessen Philbrook, Heather, additional, Obeid, Wassim, additional, Fried, Linda F., additional, Heerspink, Hiddo J.L., additional, Ix, Joachim H., additional, Shlipak, Michael G., additional, Kimmel, Paul L., additional, Parikh, Chirag R., additional, and Grams, Morgan E., additional
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- 2022
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41. Pre-Operative Kidney Biomarkers and Risks for Death, Cardiovascular and Chronic Kidney Disease Events after Cardiac Surgery: The TRIBE-AKI Study
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Parikh, Chirag R., primary, Vasquez-Rios, George, additional, Moledina, Dennis G., additional, Jia, Yaqi, additional, McArthur, Eric, additional, Mansour, Sherry G., additional, Thiessen-Philbrook, Heather, additional, Shlipak, Michael G., additional, Koyner, Jay L., additional, Garg, Amit X., additional, and Coca, Steven G., additional
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- 2022
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42. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
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Zhao, Bixiao, Lu, Qiongshi, Cheng, Yuwei, Belcher, Justin M., Siew, Edward D., Leaf, David E., Body, Simon C., Fox, Amanda A., Waikar, Sushrut S., Collard, Charles D., Thiessen-Philbrook, Heather, Ikizler, Alp T., Ware, Lorraine B., Edelstein, Charles L., Garg, Amit X., Choi, Murim, Schaub, Jennifer A., Zhao, Hongyu, Lifton, Richard P., and Parikh, Chirag R.
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- 2017
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43. YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation
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Puthumana, Jeremy, Hall, Isaac E., Reese, Peter P., Schröppel, Bernd, Weng, Francis L., Thiessen-Philbrook, Heather, Doshi, Mona D., Rao, Veena, Lee, Chun Geun, Elias, Jack A., Cantley, Lloyd G., and Parikh, Chirag R.
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- 2017
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44. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery
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Greenberg, Jason H., Whitlock, Richard, Zhang, William R., Thiessen-Philbrook, Heather R., Zappitelli, Michael, Devarajan, Prasad, Eikelboom, John, Kavsak, Peter A., Devereaux, P. J., Shortt, Colleen, Garg, Amit X., and Parikh, Chirag R.
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Cardiopulmonary bypass -- Research -- Complications and side effects ,Interleukins -- Research -- Physiological aspects ,Acute kidney failure -- Research -- Risk factors ,Health - Abstract
Background Children undergoing cardiac surgery may exhibit a pronounced inflammatory response to cardiopulmonary bypass (CPB). Inflammation is recognized as an important pathophysiologic process leading to acute kidney injury (AKI). The aim of this study was to evaluate the association of the inflammatory cytokines interleukin (IL)-6 and IL-10 with AKI and other adverse outcomes in children after CPB surgery. Methods This is a sub-study of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) cohort, including 106 children ranging in age from 1 month to 18 years undergoing CPB. Plasma IL-6 and IL-10 concentrations were measured preoperatively and postoperatively [day 1 (within 6 h after surgery) and day 3]. Results Stage 2/3 AKI, defined by at least a doubling of the baseline serum creatinine concentration or dialysis, was diagnosed in 24 (23 %) patients. The preoperative IL-6 concentration was significantly higher in patients with stage 2/3 AKI [median 2.6 pg/mL, interquartile range (IQR) 2.6 0.6-4.9 pg/mL] than in those without stage 2/3 AKI (median 0.6 pg/mL, IQR 0.6-2.2 pg/mL) (p = 0.03). After adjustment for clinical and demographic variables, the highest preoperative IL-6 tertile was associated with a sixfold increased risk for stage 2/3 AKI compared with the lowest tertile (adjusted odds ratio 6.41, 95 % confidence interval 1.16-35.35). IL-6 and IL-10 levels increased significantly after surgery, peaking postoperatively on day 1. First postoperative IL-6 and IL-10 measurements did not significantly differ between patients with stage 2/3 AKI and those without stage 2/3 AKI. The elevated IL-6 level on day 3 was associated with longer hospital stay (p = 0.0001). Conclusions Preoperative plasma IL-6 concentration is associated with the development of stage 2/3 AKI and may be prognostic of resource utilization. Electronic supplementary material The online version of this article (doi:10.1007/s00467-015-3088-4) contains supplementary material, which is available to authorized users., Author(s): Jason H. Greenberg[sup.1] [sup.2] , Richard Whitlock[sup.6] , William R. Zhang[sup.2] , Heather R. Thiessen-Philbrook[sup.3] , Michael Zappitelli[sup.4] , Prasad Devarajan[sup.5] , John Eikelboom[sup.6] , Peter A. Kavsak[sup.7] , [...]
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- 2015
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45. Clinically adjudicated deceased donor acute kidney injury and graft outcomes
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Mansour, Sherry G., primary, Khoury, Nadeen, additional, Kodali, Ravi, additional, Virmani, Sarthak, additional, Reese, Peter P., additional, Hall, Isaac E., additional, Jia, Yaqi, additional, Yamamoto, Yu, additional, Thiessen-Philbrook, Heather R., additional, Obeid, Wassim, additional, Doshi, Mona D., additional, Akalin, Enver, additional, Bromberg, Jonathan S., additional, Harhay, Meera N., additional, Mohan, Sumit, additional, Muthukumar, Thangamani, additional, Singh, Pooja, additional, Weng, Francis L., additional, Moledina, Dennis G., additional, Greenberg, Jason H., additional, Wilson, Francis P., additional, and Parikh, Chirag R., additional
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- 2022
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46. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19
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Menez, Steven, primary, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Wilson, F. Perry, additional, Obeid, Wassim, additional, Simonov, Michael, additional, Yamamoto, Yu, additional, Corona-Villalobos, Celia P., additional, Chang, Crystal, additional, Garibaldi, Brian T., additional, Clarke, William, additional, Farhadian, Shelli, additional, Dela Cruz, Charles, additional, Coca, Steven G., additional, Parikh, Chirag R., additional, Ko, Albert, additional, Iwasaki, Akiko, additional, Nelson, Allison, additional, Casanovas-Massana, Arnau, additional, White, Elizabeth B., additional, Schulz, Wade, additional, Coppi, Andreas, additional, Young, Patrick, additional, Nunez, Angela, additional, Shepard, Denise, additional, Matos, Irene, additional, Strong, Yvette, additional, Anastasio, Kelly, additional, Brower, Kristina, additional, Kuang, Maxine, additional, Chiorazzi, Michael, additional, Bermejo, Santos, additional, Vijayakumar, Pavithra, additional, Geng, Bertie, additional, Fournier, John, additional, Minasyan, Maksym, additional, Muenker, M. Catherine, additional, Moore, Adam J., additional, and Nadkarni, Girish, additional
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- 2022
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47. Molecular and clinical signatures in Acute Kidney Injury define distinct subphenotypes that associate with death, kidney, and cardiovascular events
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Vasquez-Rios, George, primary, Oh, Wonsuk, additional, Lee, Samuel, additional, Bhatraju, Pavan, additional, Mansour, Sherry G., additional, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Siew, Eddie, additional, Garg, Amit X., additional, Chinchilli, Vernon M., additional, Kaufman, James S., additional, Hsu, Chi-yuan, additional, Liu, Kathleen D., additional, Kimmel, Paul L., additional, Go, Alan S., additional, Wurfel, Mark M., additional, Himmelfarb, Jonathan, additional, Parikh, Chirag R., additional, Coca, Steven G., additional, and Nadkarni, Girish N., additional
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- 2021
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48. Pre-Operative Kidney Biomarkers and Risks for Death, Cardiovascular and Chronic Kidney Disease Events: The TRIBE-AKI Study
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Vasquez-Rios, George, primary, Moledina, Dennis G., additional, Jia, Yaqi, additional, McArthur, Eric, additional, Mansour, Sherry G., additional, Thiessen-Philbrook, Heather, additional, Shlipak, Michael G., additional, Koyner, Jay L., additional, Garg, Amit X., additional, Parikh, Chirag R., additional, and Coca, Steve G., additional
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- 2021
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49. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events after Hospitalization: Findings from ASSESS-AKI and ARID studies
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Coca, Steven G., primary, Vasquez-Rios, George, additional, Mansour, Sherry G., additional, Moledina, Dennis G., additional, Thiessen-Philbrook, Heather, additional, Wurfel, Mark M., additional, Himmelfarb, Jonathan, additional, Siew, Eddie, additional, Garg, Amit X., additional, Hsu, Chi-yuan, additional, Liu, Kathleen D., additional, Kimmel, Paul L., additional, Chinchilli, Vernon M., additional, Kaufman, James S., additional, Wilson, Michelle, additional, Banks, Rosamonde E, additional, Packington, Rebecca, additional, McCole, Eibhlin, additional, Kurth, Mary Jo, additional, Richardson, Ciaran, additional, Go, Alan S., additional, Selby, Nicholas M, additional, and Parikh, Chirag R., additional
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- 2021
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50. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes.
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Chen, Teresa K., Coca, Steven G., Thiessen-Philbrook, Heather R., Heerspink, Hiddo J.L., Obeid, Wassim, Ix, Joachim H., Fried, Linda F., Bonventre, Joseph V., El-Khoury, Joe M., Shlipak, Michael G., and Parikh, Chirag R.
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KIDNEY physiology ,CHRONIC kidney failure ,DIABETIC nephropathies ,GLOMERULAR filtration rate ,BIOMARKERS - Abstract
Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR ≥30 mL/min/1.73 m
2 if randomization eGFR ≥60 or ≥50% if randomization eGFR <60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. Covariates included age, sex, race, BMI, systolic BP, HbA1c, treatment arm, eGFR, and UACR. In a subset of participants with 12-month samples (n = 712), we evaluated associations of KIM-1, MCP-1, and YKL-40 change (from baseline to 12 months) with eGFR decline (from 12 months onward). Results: At baseline, mean age was 65 years, mean eGFR was 56 mL/min/1.73 m2 , and median UACR was 840 mg/g. Over a median of 2.2 years, 13% experienced kidney function decline and 9% died. In fully adjusted models, the highest versus lowest quartiles of MCP-1 and YKL-40 were associated with 2.18- and 1.76-fold higher risks of kidney function decline, respectively. One-year changes in KIM-1, MCP-1, and YKL-40 were not associated with subsequent eGFR decline. Higher baseline levels of NGAL, IL-18, MCP-1, and YKL-40 levels (per 2-fold higher) were independently associated with 10–40% higher risk of mortality. Conclusion: Among Veterans with diabetes and CKD, urinary biomarkers of tubular health were associated with kidney function decline and mortality. [ABSTRACT FROM AUTHOR]- Published
- 2022
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