1,108 results on '"Thierry Roisnel"'
Search Results
2. Synthesis, characterization and identification of inhibitory activity on the main protease of COVID-19 by molecular docking strategy of (4-oxo-piperidinium ethylene acetal) trioxonitrate
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Sofian Gatfaoui, Noureddine Issaoui, Aleksandr S. Kazachenko, Omar M. Al-Dossary, Thierry Roisnel, and Houda Marouani
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Synthesis ,X-ray diffraction ,DFT ,Chemical docking ,COVID-19 ,Hirshfeld surface ,Science (General) ,Q1-390 - Abstract
In this investigation a single crystal of (4-oxo-piperidinium ethylene acetal) trioxonitrate (4-OPEAN) was synthesized by modifying the mechanism of gradual evaporation at ambient temperature. The operational groupings are found in the complex material in the elaborate substance, according to the infrared spectrum. Single crystal X-ray diffraction suggests, (4-OPEAN) with the chemical formula (C7H12NO2)NO3 belongs to the orthorhombic space group Pnma and is centrosymmetric in three dimensions with the aforementioned network configurations, a = 11.7185(8) Å, b = 7.2729(6) Å, c = 11.0163(8) Å, Z = 4, V = 938.89(12) Å3, R = 0.0725 and wR = 0.1762. Many NH…O and CH…O hydrogen bridges, both bifurcated and non-bifurcated, link the 4-oxo-piperidinium ethylene acetal cations to the trigonal (NO3−) anions. Molecular geometry and optimal parameters of (4-OPEAN) have been determined via DFT computations at the theory-level B3LYP/6-311 ++ G(d, p), these have been contrasted with the X-ray data already available. Hirshfeld surface analysis has made it possible for the visualization and quantification of relationships between molecules in the crystal composition. Quantum theory atoms in molecules, electron location function, decreased density gradient, and localized orbital locator research have all been used to explore non-covalent interactions in crystal structure. In order to pinpoint both the nucleophilic and electrophilic locations that support hydrogen bond formation, the molecule electrostatic potential was determined. The greatest and lowest energies of occupied and unfilled molecular orbitals, together with additional derived atomic characteristics, show the material to be extremely stable and hard. According to a molecular docking study, 4-OPEAN may exhibit inhibiting effects on the 6Y84 and 7EJY virus proteins from corona (COVID-19).
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- 2023
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3. Synthesis, Characterization and Chemistry of Tetrakis(Propargylisocyanide) Copper(I) Complex
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Alexandre Quelhas, Thierry Roisnel, Jean-Claude Guillemin, and Yann Trolez
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isocyanide ,copper ,cycloaddition ,Ugi reaction ,Inorganic chemistry ,QD146-197 - Abstract
The kinetically unstable propargylisocyanide was reacted with the tetrakis(acetonitrile) copper(I) hexafluorophosphate and the formed complex was then involved in a copper-catalyzed alkyne-azide cycloaddition reaction (CuAAC). After the decomplexation of the adduct, the isocyanide was engaged in a Ugi reaction. By such a complexation, reactions can be carried out on the CC triple bond without the constraint of the instability of the free compound or the competitive reactivity of the isocyanide group.
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- 2023
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4. An Asymmetric Dinuclear Bis(ansa-Zirconocene) Complex: Synthesis and Performance in Olefin (co-)Polymerization
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Lars N. Jende, Thierry Roisnel, Virginie Cirriez, Alexandre Welle, Evgueni Kirillov, and Jean-Francois Carpentier
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dinuclear complexes ,group 4 metallocenes ,olefin polymerization catalysis ,copolymers ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
A synthetic strategy to access asymmetric dinuclear bis(ansa-metallocene) pre-catalysts is described. As a key step, the Pd-catalyzed Suzuki cross-coupling of 9,9-bis(trimethylsilyl)-fluoren-2-yl-boronic acid with a substituted 2-bromo-9H-fluorene generates an asymmetric 2,2′-bifluorene platform, which can be individually functionalized at the two differentiated 9-positions. Herein, as a first demonstration of this strategy, we report the asymmetric dinuclear bis(ansa-zirconocene) complex 2,2′-[{Me2C(Flu)(Cp)}ZrCl2][{Me2C(7-tBuFlu)(Cp)}ZrCl2], which has been characterized with NMR spectroscopy and high-resolution mass spectrometry. The performance of this bimetallic pre-catalyst when combined with MAO has been evaluated in ethylene, propylene, and ethylene/1-hexene (co-)polymerization. This pre-catalyst is revealed to be less productive than the mononuclear reference pre-catalyst {Me2C(2,7-tBuFlu)(Cp)}ZrCl2, likely because of higher steric hindrance induced by the linkage at the difluorenyl platform. The resulting (co-)polymers featured only slight differences in terms of molecular weights, tacticity, and comonomer incorporation. No bimodal molecular weight distribution was achieved at any produced polymer; this might have originated from the close similarity of the connected Cp/Flu moieties or a rapid chain-transfer phenomenon between the different active sites which were quite close to each other.
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- 2023
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5. Role of Non-Covalent Interactions in Novel Supramolecular Compound, Bis(4-phenylpiperazin-1-ium) Oxalate Dihydrate: Synthesis, Molecular Structure, Thermal Characterization, Spectroscopic Properties and Quantum Chemical Study
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Mahdi Jemai, Marwa Khalfi, Noureddine Issaoui, Thierry Roisnel, Aleksandr S. Kazachenko, Omar Al-Dossary, Houda Marouani, Anna S. Kazachenko, and Yuriy N. Malyar
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single-crystal X-ray diffraction ,1-phenylpiperazine ,oxalate ,infrared spectrum ,ultraviolet-visible spectrometry ,quantum chemical calculations ,Crystallography ,QD901-999 - Abstract
The stoichiometric ratio 2:1 mix of 1-phenylpiperazine and oxalic acid dihydrate followed by slow evaporation results in a new material, bis(4-phenylpiperazin-1-ium) oxalate dihydrate, with the general chemical formula (C10H15N2)2(C2O4).2H2O, indicated by PPOXH. The title compound’s asymmetric unit and three-dimensional network have been determined by single crystal X-ray diffraction. Intermolecular O-H…O, N-H…O and C-H…O hydrogen bonding assist in maintaining and stabilization of the crystal structure of this new compound. Hirshfeld surface analysis and two-dimensional fingerprints have been performed to quantify the non-covalent interactions in the PPOXH structure. The vibrational modes of the different characteristic groups of the title chemical were identified using infrared spectrum analysis. The thermal characterization of this product was studied by a coupled TG/DTA analysis. The ultraviolet-visible absorption spectrum has been used to study the optical properties and the energy gap of this compound. DFT calculations were employed to evaluate the composition and properties of PPOXH. The analysis of HOMO-LUMO frontier orbitals analysis allows us to understand the chemical reactivity of this supramolecular compound and to determine the electrophilic and nucleophilic sites responsible for electron transfer. Topological analysis (AIM), reduced density gradient (RDG), molecular electrostatic potential surface (MEPS) and Mulliken population were analyzed to evaluate the types of non-covalent interactions, localization of electrons in space, atomic charges and molecular polarity in depth.
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- 2023
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6. Crystal Structure of New 1-Phenyl-Substituted Tribenzsilatranes
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Vitalijs Romanovs, Sergey Belyakov, Evgeniya Doronina, Valery Sidorkin, Thierry Roisnel, and Viatcheslav Jouikov
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silatranes ,tribenzsilatranes ,crystal structure analysis ,intramolecular dative bonds ,Crystallography ,QD901-999 - Abstract
The family of practically requested “common” silatrane derivatives of triethanolamine X-Si(OCH2CH2)3N, 1, was enlarged with the first representatives of 3,4,6,7,10,11-tribenzo-2,8,9trioxa-5-aza-1-silatricyclo(3.3.3.0^1,5^)undecanes X-Si(O-para-R-C6H3)3N, tribenzsilatranes 2 (R = H (a), Me (b), F (c)), carrying the substituent R in the side aromatic rings. These compounds were prepared via the transesterification of phenyl trimethoxysilane with the corresponding triphenol amines and studied using XRD and DFT calculations. These derivatives of 1-X-(4-R-2,2′,2′′-nitrilotriphenoxy)silane are expected to have, as their parent “common” silatranes 1, diverse biological and pharma activities. A common characteristic feature of the molecular structures of both 1 and 2 is the presence of an intramolecular dative bond N→Si whose existence is evidenced by geometric and quantum topological (AIM) criteria. In the crystals, the length of this bond (dSiN) is noticeably longer in tribenzsilatranes than in 1. The results of DFT B3PW91/6-311++G(d,p) calculations suggest the reason for this to be the more rigid nature of the potential functions of the N→Si bond deformation in 2 compared to 1. The relative degree of “softness”/”hardness” of the potential functions can be assessed from the difference in the calculated values of dSiN in isolated molecules 1 and 2a–c and in their crystals.
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- 2023
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7. Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation
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Mansoura Bourwina, Sandra Walha, Najeh Krayem, Riadh Badraoui, Faten Brahmi, Wejdan M. Alshammari, Mejdi Snoussi, Mark M. Turnbull, Thierry Roisnel, and Houcine Naïli
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manganese (II) complex ,thermal analysis ,infrared spectroscopy ,optical band gap ,magnetic properties ,pharmacokinetics ,Inorganic chemistry ,QD146-197 - Abstract
A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C5H14N2)[MnCl4(H2O)2] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl4(H2O)2]2−. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses.
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- 2023
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8. Synthesis, Empirical and Theoretical Investigations on New Histaminium Bis(Trioxonitrate) Compound
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Mahdi Jmai, Sofian Gatfaoui, Noureddine Issaoui, Thierry Roisnel, Aleksandr S. Kazachenko, Omar Al-Dossary, Houda Marouani, and Anna S. Kazachenko
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organic–inorganic material ,histamine ,single-crystal X-ray diffraction ,infrared spectrum ,ultraviolet–visible spectrometry ,spectrofluorimetry ,Organic chemistry ,QD241-441 - Abstract
In this paper, a novel hybrid material, entitled histaminium bis(trioxonitrate), with the general chemical formula (C5H11N3)(NO3)2, denoted by HTN was presented. Single-crystal X-ray diffraction was used to determine the structural characteristics of this compound after it was made using a slow evaporation method at room temperature. This compound was elaborated and crystallized to the monoclinic system with space group P21/c, and the lattice parameters obtained were: a = 10.4807 (16)Å, b = 11.8747 (15)Å, c = 16.194 (2)Å, β = 95.095 (6)°, V = 2007.4 (5)Å3 and Z = 8. The title compound’s atomic structure couldbe modeled as a three-dimensional network. Organic cations and nitrate anions were connected via N–H...O and C–H...O hydrogen bonds in the HTN structure. The intermolecular interactions responsible for the formation of crystal packing were evaluated using Hirshfeld surfaces and two-dimensional fingerprint plots. The compound’s infrared spectrum, which ranged from 4000 to 400 cm−1, confirmed the presence of the principal bands attributed to the internal modes of the organic cation and nitrate anions. Additionally, spectrofluorimetry and the ultraviolet–visible spectrum was used to investigate this compound. DFT calculations were used to evaluate the composition and properties of HTN. The energy gap, chemical reactivity and crystal stability of HTN were quantified by performing HOMO-LUMO frontier orbitals analysis. Topological analysis (AIM), Reduced Density Gradient (RDG), molecular electrostatic potential surface (MEPS) and Mulliken population were processed to determine the types of non-covalent interactions, atomic charges and molecular polarity in detail.
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- 2023
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9. Self-assembly of a new cobalt complex, (C6H14N2)3[CoCl4]Cl: Synthesis, empirical and DFT calculations
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Mariem Tahenti, Noureddine Issaoui, Thierry Roisnel, Houda Marouani, Omar Al-Dossary, and Aleksandr S. Kazachenko
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Hirshfeld surfaces ,ELF ,AIM ,RDG ,NCI ,Science (General) ,Q1-390 - Abstract
The aim of this work is the preparation and the crystallization of new organic–inorganic hybrid compound including cyclohexylamine and [CoCl4]2−, (C6H14N2)3[CoCl4]Cl. Our compound has been studied by single-crystal X-ray diffraction (XRD), IR and TG-DTA examination. The XRD investigation allows to structurally distinguish our material by its monoclinic system and P21/n space group through the lattice parameters a = 15.2645 (12) Å, b = 10.0843 (7) Å, c = 17.4450 (13) Å, β = 95.957 (3)° and Z = 4. The crystal arrangement shows inorganic entities of [CoCl4]2− and chloride spreading in (10 1-) plane which are connected to cyclohexylammonium cations via N(C)–H…Cl H-bonds. The experimental studies on the compound have been accompanied computationally by DFT calculations via the B3LYP functional. The intermolecular interactions using were quantitatively studied by 3D-HS coupled with two dimensional fingerprint (2D-FP) plots and analyzed by the RDG and AIM approaches. The electron localization function (ELF) investigation was performed to explain the chemical structure of (C6H14N2)3[CoCl4]Cl.
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- 2022
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10. Chemistry of CS2 and CS3 Bridged Decaborane Analogues: Regular Coordination Versus Cluster Expansion
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Ketaki Kar, Suvam Saha, Rahul Maganbhai Parmar, Arindam Roy, Marie Cordier, Thierry Roisnel, and Sundargopal Ghosh
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metallaheteroborane ,fusion ,coordination ,expansion ,cluster ,Organic chemistry ,QD241-441 - Abstract
In an effort to synthesize metallaheteroborane clusters of higher nuclearity, the reactivity of metallaheteroboranes, nido-[(Cp*M)2B6S2H4(CS3)] (Cp* = C5Me5) (1: M = Co; 2: M = Rh) with various metal carbonyls have been investigated. Photolysis of nido-1 and nido-2 with group 6 metal carbonyls, M’(CO)5.THF (M’ = Mo or W) were performed that led to the formation of a series of adducts [(Cp*M)2B6S2H4(CS3){M’(CO)5}] (3: M = Co, M’ = Mo; 4: M = Co, M’ = W; 5: M = Rh, M’ = Mo; 6: M = Rh, M’ = W) instead of cluster expansion reactions. In these adducts, the S atom of C=S group of di(thioboralane)thione {B2CS3} moiety is coordinated to M’(CO)5 (M = Mo or W) in η1-fashion. On the other hand, thermolysis of nido-1 with Ru3(CO)12 yielded one fused metallaheteroborane cluster [{Ru(CO)3}3S{Ru(CO)}{Ru(CO)2}Co2B6SH4(CH2S2){Ru(CO)3}2S], 7. This 20-vertex-fused cluster is composed of two tetrahedral {Ru3S} and {Ru2B2}, a flat butterfly {Ru3S} and one octadecahedron {Co2RuB7S} core with one missing vertex, coordinated to {Ru2SCH2S2} through two boron and one ruthenium atom. On the other hand, the room temperature reaction of nido-2 with Co2(CO)8 produced one 19-vertex fused metallaheteroborane cluster [(Cp*Rh)2B6H4S4{Co(CO)}2{Co(CO)2}2(μ-CO)S{Co(CO)3}2], 8. Cluster 8 contains one nido-decaborane {Rh2B6S2}, one butterfly {Co2S2} and one bicapped square pyramidal {Co6S} unit that exhibits an intercluster fusion with two sulfur atoms in common. Clusters 3–6 have been characterized by multinuclear NMR and IR spectroscopy, mass spectrometry and structurally determined by XRD analyses. Furthermore, the DFT calculations have been carried out to gain insight into electronic, structural and bonding patterns of the synthesized clusters.
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- 2023
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11. New synthetic material removing heavy metals from aqueous solutions and wastewater
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Benayed Houari, Samira Louhibi, Khadidja Tizaoui, Leila Boukli-hacene, Belkacem Benguella, Thierry Roisnel, and Vincent Dorcet
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Chemistry ,QD1-999 - Abstract
(E)-2-[(1H-Imidazol-4-yl)methylidene]-Hydrazinecarbothioamide ligand (EIMH) was investigated to remove heavy metal ions from wastewater. Thus, the present study leads to the adsorption/complexation of Pb2+, Cu2+ and Cd2+ in aqueous solution on EIMH under various conditions such as contact time, temperature, and pH. The EIMH ligand was characterized using FTIR and X-ray diffraction. The metal ion concentration in the aqueous samples was analyzed by atomic absorption spectrophotometer. The uptake is rapid with maximum adsorption being observed within 10 min for Pb2+, Cu2+ and Cd2+. Results obtained revealed that 99.80% of lead, 99.25% of copper and 98.68% of cadmium were removed at pH 2–8. The calculated thermodynamic parameters indicate that the adsorption of heavy metals onto EIMH is physical in nature. Finally, EIMH is able to remove the three heavy metals to a concentration less than 0.5 ppm from wastewater and with an efficiency of 96.81% for lead, 99.44% for copper and 97.76% for cadmium. Keywords: Synthesis ligand, Crystal structure, Adsorption, Wastewater, Metal
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- 2019
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12. Synthesis, structure, photophysical properties and biological activity of a cobalt(II) coordination complex with 4,4′-bipyridine and porphyrin chelating ligands
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Nesrine Amiri, Sahar Nouir, Melek Hajji, Thierry Roisnel, Taha Guerfel, Gérard Simonneaux, and Habib Nasri
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Chemistry ,QD1-999 - Abstract
A new bioactive material of cobalt(II) with 5,10,15,20-tetrakis[4 (benzoyloxy)phenyl] porphyrin (TPBP) and bpy ligands ([CoII(TPBP)(bpy)2] 1) has been synthesized and characterized by Single-crystal X-ray diffraction (SCXRD), spectroscopic methods and quantum-chemistry calculations. In the crystalline structures of six coordinated Co(II) [CoII(TPBP)(bpy)2] 1, linear 1D polymeric chains were observed in which all the porphyrin units are aligned parallel to each other. The crystal packing is stabilized by inter-and intramolecular C–H⋯O and C–H⋯N hydrogen bonds, and by weak C–H⋯Cg π interactions. Interestingly, NBO–Second-order perturbation theory analysis, carried out at the UB3LYP/6-31G(d)/SDD DFT level of theory, demonstrated that a two-center bond between the nitrogen atoms and the cobalt ions (Co) was not found, the Co–Npy/bp interactions are coming from an electronic delocalization between the Npy/Nbp filled orbitals to the anti-bonding LP*(4) and LP*(5) metal NBOs. Mass spectroscopy, and elemental analysis were also investigated to confirm the molecular structure. The downfield shift and the peak broadening of the axial ligand resonances observed in the 1H NMR indicated the contiguity to the paramagnetic Co(II) center. Additionally, the photophysical properties have been evaluated by UV–visible absorption, and fluorescence emission spectroscopies. Finally, bioactivity investigations revealed that free porphyrin TPBP, CoIITPBP and complex 1 could be used as potential antioxidant agents. Keywords: Cobalt(II)-porphyrin framework, X-ray crystallography, DFT, Optical spectroscopies, Antioxidant activity
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- 2019
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13. Crystal structure of {4-[10,15,20-tris(4-methoxyphenyl)porphyrin-5-yl]benzyl 2-diazoacetato}zinc(II)
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Daniel Carrie, Thierry Roisnel, and Gerard Simonneaux
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crystal structure ,diazo ester ,porphyrin ,zinc ,Crystallography ,QD901-999 - Abstract
In the title compound, [Zn(C50H36N6O5)], the ZnII cation is chelated by four pyrrole N atoms of the porphyrinate anion and coordinated by a symmetry-generated keto O atom of the diazoester group in a distorted square-pyramidal geometry. The mean Zn—N(pyrrole) bond length is 2.058 Å and the Zn—O(diazoester) bond length is 2.179 (4) Å. The zinc cation is displaced by 0.2202 (13) Å from the N4C20 mean plane of the porphyrinate anion toward the O atom; the involvement of this atom leads to a [100] polymeric chain in the crystal.
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- 2020
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14. Synthesis and crystal structure of (E)-2-({2-[azaniumylidene(methylsulfanyl)methyl]hydrazinylidene}methyl)benzene-1,4-diol hydrogen sulfate
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Oussama Nehar, Samira Louhibi, and Thierry Roisnel
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crystal structure ,thiosemicarbazone ,hydrogen bonding ,organic salt ,Crystallography ,QD901-999 - Abstract
The title molecular salt, C9H12N3O2S+·HSO4−, was obtained through the protonation of the azomethine N atom in a sulfuric acid medium. The crystal comprises two entities, a thiosemicarbazide cation and a hydrogen sulfate anion. The cation is essentially planar and is further stabilized by a strong intramolecular O—H...N hydrogen bond. In the crystal, a three-dimensional network is established through O—H...O and N—H...O hydrogen bonds. A weak intermolecular C—H...O hydrogen bond is also observed. The hydrogen sulfate anion exhibits disorder over two sets of sites and was modelled with refined occupancies of 0.501 (6) and 0.499 (6).
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- 2019
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15. Homocubane Chemistry: Synthesis and Structures of Mono- and Dicobaltaheteroborane Analogues of Tris- and Tetrahomocubanes
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Kriti Pathak, Rongala Ramalakshmi, Mohammad Zafar, Sukanya Bagchi, Thierry Roisnel, and Sundargopal Ghosh
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Chemistry ,QD1-999 - Published
- 2019
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16. Regioselective Pd-catalyzed direct C1- and C2-arylations of lilolidine for the access to 5,6-dihydropyrrolo[3,2,1-ij]quinoline derivatives
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Hai-Yun Huang, Haoran Li, Thierry Roisnel, Jean-François Soulé, and Henri Doucet
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catalysis: C–C bond formation ,C–H bond activation ,lilolidine ,palladium ,Science ,Organic chemistry ,QD241-441 - Abstract
The Pd-catalyzed C–H bond functionalization of lilolidine was investigated. The use of a palladium-diphosphine catalyst associated to acetate bases in DMA was found to promote the regioselective arylation at α-position of the nitrogen atom of lilolidine with a wide variety of aryl bromides. From these α-arylated lilolidines, a second arylation at the β-position gives the access to α,β-diarylated lilolidines containing two different aryl groups. The one pot access to α,β-diarylated lilolidines with two identical aryl groups is also possible by using a larger amount of aryl bromide. The synthesis of 5,6-dihydrodibenzo[a,c]pyrido[3,2,1-jk]carbazoles from lilolidine via three successive direct arylations is also described. Therefore, this methodology provides a straightforward access to several lilolidine derivatives from commercially available compounds via one, two or three C–H bond functionalization steps allowing to tune their biological properties.
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- 2019
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17. (E,E)-3-Methyl-2,5-bis(4-methylbenzylidene)cyclopentanone: synthesis, characterization, Hirshfeld surface analysis and antibacterial activity
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Fatiha Mahdi, Assia Sid, Rafika Bouchene, Paul Mosset, and Thierry Roisnel
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Claisen–Schmidt reaction ,crossed-aldol condensation ,crystal structure ,spectroscopic studies ,Crystallography ,QD901-999 - Abstract
The title compound, (E,E)-3-methyl-2,5-bis(4-methylbenzylidene)cyclopentanone (MBMCP), C22H22O, was obtained by Claisen–Schmidt condensation of 4-methylbenzaldehyde with 3-methylcyclopentanone in good yield. The structure of MBMCP was studied using UV, FT–IR and Raman spectroscopy, single-crystal X-ray diffraction (XRD) measurements, and 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The molecular structure of MBMCP is fully extended in the E,E configuration. C—H...π stacking interactions play a significant role in the stabilization of the molecular packing. Hirshfeld surface analysis was used to quantify the non-covalent interactions in the crystal lattice. Microbiological studies were performed to investigate the antimicrobial activity of this new product.
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- 2019
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18. Enantiomeric Amino Acid Schiff Base Copper(II) Complexes as a New Class of RNA-Targeted Metallo-Intercalators: Single X‑ray Crystal Structural Details, Comparative in Vitro DNA/RNA Binding Profile, Cleavage, and Cytotoxicity
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Siffeen Zehra, Thierry Roisnel, and Farukh Arjmand
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Chemistry ,QD1-999 - Published
- 2019
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19. Design of bis-NHC Ru-complexes featuring diarylmethylene N-substituents for olefin metathesis
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Idriss Curbet, Jennifer Morvan, Sophie Colombel-Rouen, Thierry Roisnel, Christophe Crévisy, and Marc Mauduit
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Organic chemistry ,QD241-441 - Published
- 2019
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20. Synthesis, Characterization, DFT and Photocatalytic Studies of a New Pyrazine Cadmium(II) Tetrakis(4-methoxy-phenyl)-porphyrin Compound
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Chadlia Mchiri, Louis-Charl C. Coetzee, Faycal Chandoul, Abdesslem Jedidi, Adedapo S. Adeyinka, Nomampondo Magwa, Thierry Roisnel, Sana Ben Moussa, and Habib Nasri
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cadmium porphyrin ,molecular structure ,DFT-calculations ,NBO analysis ,photocatalytic activity ,non-covalent interactions (NCI) ,Organic chemistry ,QD241-441 - Abstract
This study describes the synthesis, theoretical investigations, and photocatalytic degradational properties of a new (pyrazine)(meso-tetrakis(4-tert-methoxyphenyl)-porphyrinato)-cadmium (II) ([Cd(TMPP)-Pyz]) complex (1). The new penta-coordinated CdII porphyrin complex (1) was characterized by various spectroscopic techniques, including FT-IR, NMR, UV-visible absorption, fluorescence emission, and singlet oxygen, while its molecular structure was studied using single crystal X-ray diffraction. The UV–Vis spectroscopic study highlighted the redshift of the absorption bands after the insertion of the Cd(II) metal ion into the TMPP ring. The co-coordination of the pyrazine axial ligand enhanced this effect. A fluorescence emission spectroscopic study showed a significant blueshift in the Q bands, accompanied by a decrease in the fluorescence emission intensity and quantum yields of Φf = 0.084, Φf = 0.06 and Φf = 0.03 for H2-TMPP free-base porphyrin, [Cd(TMPP)] and [Cd(TMPP)(Pyz)] (1) respectively. Singlet oxygen revealed that the H2-TMPP porphyrin produced the most efficient singlet oxygen quantum yield of (ΦΔ = 0.73) compared to [CdTMPP] (ΦΔ = 0.57) and [Cd(TMPP)(Pyz)] (1) (ΦΔ = 0.13). In the crystal lattice, the [Cd(TMPP)Pyz] was stabilized through non-covalent intermolecular interactions (NCI), such as the hydrogen bonds C-H···N and C-H···Cg. Additionally, crystal explorer software was then utilized to measure the quantitative analysis of the intermolecular interactions in the unit cell of the crystal structure and established that the C-H···π interaction dominated. The Natural bond orbital (NBO) analysis revealed that each molecule is stabilized by hyperconjugation and charge delocalization. As a photocatalyst, the coordination complex 1 showed excellent photocatalytic activity toward the degradation of Levafix Blue CA reactive dye (i.e., dye photo-degradation of 80%).
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- 2022
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21. Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes
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Yann Le Gal, Agathe Filatre-Furcate, Dominique Lorcy, Olivier Jeannin, Thierry Roisnel, Vincent Dorcet, Diana Fontinha, Denise Francisco, Miguel Prudncio, Marta Martins, Catarina Soeiro, Sílvia A. Sousa, Jorge H. Leitão, Tnia S. Morais, Ins Bártolo, Nuno Taveira, Joana F. Guerreiro, and Fernanda Marques
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gold bis(dithiolene) complexes ,diselenolene ,structural modification ,anticancer activity ,antimicrobial activity ,HSA interaction ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The biological properties of sixteen structurally related monoanionic gold (III) bis(dithiolene/ diselenolene) complexes were evaluated. The complexes differ in the nature of the heteroatom connected to the gold atom (AuS for dithiolene, AuSe for diselenolene), the substituent on the nitrogen atom of the thiazoline ring (Me, Et, Pr, iPr and Bu), the nature of the exocyclic atom or group of atoms (O, S, Se, C(CN)2) and the counter-ion (Ph4P+ or Et4N+). The anticancer and antimicrobial activities of all the complexes were investigated, while the anti-HIV activity was evaluated only for selected complexes. Most complexes showed relevant anticancer activities against Cisplatin-sensitive and Cisplatin-resistant ovarian cancer cells A2780 and OVCAR8, respectively. After 48 h of incubation, the IC50 values ranged from 0.1–8 μM (A2780) and 0.8–29 μM (OVCAR8). The complexes with the Ph4P+ ([P]) counter-ion are in general more active than their Et4N+ ([N]) analogues, presenting IC50 values in the same order of magnitude or even lower than Auranofin. Studies in the zebrafish embryo model further showed that, despite their marked anticancer effect, the complexes with [P] counter-ion exhibited low in vivo toxicity. In general, the exocyclic exchange of sulfur by oxygen or ylidenemalononitrile (C(CN)2) enhanced the compounds toxicity. Most complexes containing the [P] counter ion exhibited exceptional antiplasmodial activity against the Plasmodium berghei parasite liver stages, with submicromolar IC50 values ranging from 400–700 nM. In contrast, antibacterial/fungi activities were highest for most complexes with the [N] counter-ion. Auranofin and two selected complexes [P][AuSBu(=S)] and [P][AuSEt(=S)] did not present anti-HIV activity in TZM-bl cells. Mechanistic studies for selected complexes support the idea that thioredoxin reductase, but not DNA, is a possible target for some of these complexes. The complexes [P] [AuSBu(=S)], [P] [AuSEt(=S)], [P] [AuSEt(=Se)] and [P] [AuSeiPr(=S)] displayed a strong quenching of the fluorescence intensity of human serum albumin (HSA), which indicates a strong interaction with this protein. Overall, the results highlight the promising biological activities of these complexes, warranting their further evaluation as future drug candidates with clinical applicability.
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- 2022
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22. Synthesis of Polysubstituted Ferrocenesulfoxides
- Author
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Min Wen, William Erb, Florence Mongin, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, and Thierry Roisnel
- Subjects
ferrocene ,sulfoxide ,deprotonative metalation ,chiral directing group ,CH acidity ,stereoselectivity ,Organic chemistry ,QD241-441 - Abstract
The purpose of the study is to design synthetic methodologies, especially directed deprotometalation using polar organometallic reagents, to access polysubstituted ferrocenesulfoxides. From enantiopure 2-substituted (SiMe3, PPh2) S-tert-butylferrocenesulfoxides, a third substituent was first introduced at the 5 position (SiMe3, I, D, C(OH)Ph2, Me, PPh2, CH2NMe2, F) and removal of the trimethylsilyl group then afforded 2-substituted ferrocenesulfoxides unreachable otherwise. Attempts to apply the “halogen dance” reaction to the ferrocenesulfoxide series led to unexpected results although rationalized in light of calculated pKa values. Further functionalizations were also possible. Thus, new enantiopure, planar chiral di- and trisubstituted ferrocenes have been obtained, in addition to several original 2-substituted, 2,3- and 2,5-disubstituted, 2,3,5-trisubstituted and even 2,3,4,5-tetrasubstituted ferrocenesulfoxides, also enantiopure.
- Published
- 2022
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23. Chiral Diketopyrrolopyrrole-Helicene Polymer With Efficient Red Circularly Polarized Luminescence
- Author
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Kais Dhbaibi, Chengshuo Shen, Marion Jean, Nicolas Vanthuyne, Thierry Roisnel, Marcin Górecki, Bassem Jamoussi, Ludovic Favereau, and Jeanne Crassous
- Subjects
helicene ,diketopyrrolopyrrole ,circularly polarized luminescence ,red emitters ,exciton coupling ,chiral polymers ,Chemistry ,QD1-999 - Abstract
Chiral diketopyrrolopyrrole (DPP)-helicene polymers were synthesized to develop efficient red circularly polarized (CP) light emitters. These original chiral dyes display intense electronic circular dichroism (ECD) and CP luminescence (CPL) in the far-red spectral region owing to the presence of excitonic coupling between achiral DPPs within the chiral environment of the polymeric structure. This work affords an interesting example illustrating the potential of π-conjugated helical polymers for chiral optoelectronic applications.
- Published
- 2020
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24. Deprotometalation-Iodolysis and Direct Iodination of 1-Arylated 7-Azaindoles: Reactivity Studies and Molecule Properties
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Mohamed Yacine Ameur Messaoud, Ghenia Bentabed-Ababsa, Ziad Fajloun, Monzer Hamze, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Vincent Dorcet, and Florence Mongin
- Subjects
7-azaindole ,deprotometalation ,iodination ,regioselectivity ,N-arylation ,Organic chemistry ,QD241-441 - Abstract
Five protocols were first compared for the copper-catalyzed C-N bond formation between 7-azaindole and aryl/heteroaryl iodides/bromides. The 1-arylated 7-azaindoles thus obtained were subjected to deprotometalation-iodolysis sequences using lithium 2,2,6,6-tetramethylpiperidide as the base and the corresponding zinc diamide as an in situ trap. The reactivity of the substrate was discussed in light of the calculated atomic charges and the pKa values. The behavior of the 1-arylated 7-azaindoles in direct iodination was then studied, and the results explained by considering the HOMO orbital coefficients and the atomic charges. Finally, some of the iodides generated, generally original, were involved in the N-arylation of indole. While crystallographic data were collected for fifteen of the synthesized compounds, biological properties (antimicrobial, antifungal and antioxidant activity) were evaluated for others.
- Published
- 2021
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25. Nickel(II)-Based Building Blocks with Schiff Base Derivatives: Experimental Insights and DFT Calculations
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Néstor Novoa, Carolina Manzur, Thierry Roisnel, Samia Kahlal, Jean-Yves Saillard, David Carrillo, and Jean-René Hamon
- Subjects
nickel ,Schiff base complexes ,Sonogashira cross coupling ,X-ray crystal structure ,DFT calculations ,Organic chemistry ,QD241-441 - Abstract
We have recently reported a series of neutral square planar tridentate Schiff base (L) complexes of the general formula [(L)M(py)], showing relatively high first-order hyperpolarizabilities and NLO redox switching behavior. In the present study, new members of this family of compounds have been prepared with the objective to investigate their potential as building blocks in the on-demand construction of D-π-A push–pull systems. Namely, ternary nickel(II) building blocks of general formula [(LA/D)Ni(4-pyX)] (4–7), where LA/D stands for an electron accepting or donating dianionic O,N,O-tridentate Schiff base ligand resulting from the monocondensation of 2-aminophenol or its 4-substituted nitro derivative and β-diketones R-C(=O)CH2C(=O)CH3 (R = methyl, anisyl, ferrocenyl), and 4-pyX is 4-iodopyridine or 4-ethynylpyridine, were synthesized and isolated in 60–78% yields. Unexpectedly, the Sonogashira cross-coupling reaction between the 4-iodopyridine derivative 6 and 4-ethynylpyridine led to the formation of the bis(4-pyridyl) acetylene bridged centrosymmetric dimer [{(LD)Ni}2(µ2-py-C≡C-py)] (8). Complexes 4–8 were characterized by elemental analysis, FT-IR and NMR spectroscopy, single crystal X-ray diffraction and computational methods. In each compound, the four-coordinate Ni(II) metal ion adopts a square planar geometry with two nitrogen and two oxygen atoms as donors occupying trans positions. In 8, the Ni…Ni separation is of 13.62(14) Å. Experimental results were proved and explained theoretically exploiting Density Functional Theory calculations.
- Published
- 2021
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26. Propylene Polymerization and Deactivation Processes with Isoselective {Cp/Flu} Zirconocene Catalysts
- Author
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Xavier Desert, Thierry Roisnel, Vincent Dorcet, Katty Den Dauw, Aurélien Vantomme, Alexandre Welle, Jean-François Carpentier, and Evgueni Kirillov
- Subjects
zirconocene ,polymerization ,polypropylene ,regiocontrol ,stereocontrol ,deactivation ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
Industrially relevant single-site precatalysts used to produce isotactic polypropylene (iPP) include C2-symmetric {SBI} and C1-symmetric {Cp/Flu} complexes of group 4 metals. While the latter can produce iPPs with a higher degree of isotacticity, they also suffer from poor productivity compared to their {SBI} counterparts. Several causes for this trend have been suggested—2,1-Regioinsertions are frequently pointed out, as they are suspected to drive the catalyst into a dormant state. While this event does not seem to significantly impact the productivity of {SBI} systems, the influence of these regioerror is poorly documented for isoselective {Cp/Flu} precatalysts. To address this issue, new Ph2X(Cp)(Flu) (Ph2X = Ph2C, FluC, Ph2Si) proligands (2a–k) and some of the corresponding dichlorozirconocenes (3a–h,k) were synthesized. These new compounds were characterized and tested in homogeneous propylene polymerization at 60 °C and the amounts of regioerrors in the resulting polymers were examined by 13C NMR spectroscopy. A possible correlation between poor productivity and a high number of regioerrors was investigated and is discussed. Furthermore, a C-H activation process in the bulky nBu3C substituent upon activation of 4c (the dimethylated analog of 3c) by B(C6F5)3 has been evidenced by NMR; DFT calculations support this C-H activation as a deactivation mechanism.
- Published
- 2021
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27. Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
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Layal Hariss, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, and Ali Hachem
- Subjects
aerobic oxidative coupling ,imidazo[1,2-a]-N-heterocycles ,gem-difluoroalkyl derivatives ,propargylic fluorides ,Science ,Organic chemistry ,QD241-441 - Abstract
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.
- Published
- 2017
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28. Une surstructure de α-Ge, type diamant, induite par un dopage d'antimoine
- Author
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Adrian Gómez Herrero, Lamia Hammoudi, Mohammed Kars, Thierry Roisnel, and L. Carlos Otero-Diáz
- Subjects
crystal structure ,antimony ,doped germanium ,superstructure ,Crystallography ,QD901-999 - Abstract
Single crystals of antimony-doped germanium, Ge1–xSbx+0.01 (x ≃ 0.0625), were grown by chemical transport reaction. The alloy crystallizes as a superstructure of diamond-type α-Ge. All atoms in the asymmetric unit lie on special positions and are characterized by strong covalent bonds. The antimony atoms substitute for one germanium atom at full occupancy at Wyckoff position 4a (site symmetry -43m), and are also at an adjacent tetrahedral interstitial site with partially occupation (16%) at position 4c (or 4d) (site symmetry -43m). The structural model does not show close Sb...Sb contacts, and suggests that the interstitial antimony atoms move between the two adjacent tetrahedral sites.
- Published
- 2017
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29. Optical, UV-Vis spectroscopy studies, electrical and dielectric properties of transition metal-based of the novel organic–inorganic hybrid (C6H10N2)(Hg2Cl5)2.3H2O
- Author
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Imen Ben Saad, Najeh Hannachi, Thierry Roisnel, and Faouzi Hlel
- Subjects
optical properties ,uv-vis spectroscopy ,the impedance spectroscopy ,the temperature (303–453k) and frequency dependence of the electrical conductivity and the dielectric properties ,Electricity ,QC501-721 - Abstract
In this work, we are interested in the synthesis of new hybrid material (C6H10N2)(Hg2Cl5)2.3H2O grown by hydrothermal methods. X-ray diffraction indicates that this compound crystallizes at 150(2) K in the monoclinic system with C2/c space group, with the following unit cell parameters: a=19.6830(15) Å, b=18.1870(15) Å, c=6.8567(6) Å, β=93.224(3)∘ and Z=4. On the other hand, the optical properties of this compound were studied using ultraviolet-visible (UV-Vis) spectroscopy in the range 200–800nm. Furthermore, the optical absorbances are used to determine the absorption coefficient α and the optical band gap Eg, so the Tauc model was used to determine the optical gap energy of the compound (C6H10N2)(Hg2Cl5)2.3H2O. The analysis of the results revealed the existence of optical allowed indirect transition mechanisms with the band gap energy equal to (2.37eV) for liquid and (4.33eV) for solid. Impedance measurements indicate that the electrical and dielectric properties are strongly dependent on both temperature and frequency. Nyquist plots (Z′′ versus Z′) show that the conductivity behavior is accurately represented by an equivalent circuit model which consists of a series combination of bulk and grain boundary. Furthermore, the angular frequency dependence plots of the real and imaginary parts, ε′ and ε′′, of complex dielectric permittivity ε∗ and tan δ losses at several temperatures between 303 and 453K were studied for the title compound. Finally, the modulus plots can be characterized by the presence of two relaxation peaks.
- Published
- 2019
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30. 1,3,5-Triaryl-1,3,5-Triazinane-2,4,6-Trithiones: Synthesis, Electronic Structure and Linear Optical Properties
- Author
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Ismaël Rabouel, Nicolas Richy, Anissa Amar, Abdou Boucekkine, Thierry Roisnel, Olivier Mongin, Mark G. Humphrey, and Frédéric Paul
- Subjects
thioisocyanurates ,isocyanurates ,thionation ,DFT calculations ,cyclic thioureas ,linear optics ,Organic chemistry ,QD241-441 - Abstract
The synthesis of four new 1,3,5-triaryl-1,3,5-triazinane-2,4,6-trithione derivatives (thioisocyanurates) and two new partially thionated analogues from the corresponding 1,3,5-triaryl-1,3,5-triazinane-2,4,6-triones (isocyanurates) is reported, together with their spectroscopic properties. DFT calculations and comparison with the corresponding isocyanurates evidence the impact of the oxygen-for-sulfur replacement on the electronic structure and linear optical properties of these heterocycles. A bathochromic shift of the absorption bands and more efficient quenching of the fluorescence was observed.
- Published
- 2020
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31. Synthesis and crystal structure of ((E)-{2-[(E)-(4-hydroxynaphthalen-1-yl)methylidene]hydrazin-1-yl}(methylsulfanyl)methylidene)azanium hydrogen sulfate monohydrate
- Author
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Oussama Nehar, Samira Louhibi, Leila Boukli-Hacene, and Thierry Roisnel
- Subjects
crystal structure ,thiosemicarbazone ,synthesis ,hydrogen bonding ,Crystallography ,QD901-999 - Abstract
In the title hydrated molecular salt, C13H14N3S+·HSO4−·H2O, the protonation of the azomethine N atom in sulfuric acid medium involves the formation of the bisulfate anion. The molecular structure of the cation is obtained from the thiol tautomer of thiosemicarbazone wherein the naphthalene moiety and the conjugation of the bonds contribute to the planarity of the molecular skeleton. In the crystal, the cation, anion and water molecule of crystallization are linked by a series of O—H...O and N—H...O hydrogen bonds, forming a three-dimensional network. Within this network, there are also C—H...π interactions present involving symmetry-related naphthalene rings.
- Published
- 2016
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32. Crystal structure of an unknown solvate of (piperazine-κN){5,10,15,20-tetrakis[4-(benzoyloxy)phenyl]porphyrinato-κ4N}zinc
- Author
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Soumaya Nasri, Khaireddine Ezzayani, Ilona Turowska-Tyrk, Thierry Roisnel, and Habib Nasri
- Subjects
crystal structure ,zinc porphyrin ,piperazine ,hydrogen bonds ,UV–visible spectra ,Crystallography ,QD901-999 - Abstract
The title compound, [Zn(C72H44N4O8)(C4H10N2)] or [Zn(TPBP)(pipz] (where TPBP and pipz are 5,10,15,20-tetrakis[4-(benzoyloxy)phenyl]porphyrinato and piperazine ligands respectively), features a distorted square-pyramidal coordination geometry about the central ZnII atom. This central atom is chelated by the four N atoms of the porphyrinate anion and further coordinated by a nitrogen atom of the piperazine axial ligand, which adopts a chair confirmation. The average Zn—N(pyrrole) bond length is 2.078 (7) Å and the Zn— N(pipz) bond length is 2.1274 (19) Å. The zinc cation is displaced by 0.4365 (4) Å from the N4C20 mean plane of the porphyrinate anion toward the piperazine axial ligand. This porphyrinate macrocycle exhibits major saddle and moderate ruffling deformations. In the crystal, the supramolecular structure is made by parallel pairs of layers along (100), with an interlayer distance of 4.100 Å while the distance between two pairs of layers is 4.047 Å. A region of electron density was treated with the SQUEEZE [Spek (2015). Acta Cryst. C71, 9–18] procedure in PLATON following unsuccessful attempts to model it as being part of disordered n-hexane solvent and water molecules. The given chemical formula and other crystal data do not take into account these solvent molecules.
- Published
- 2016
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33. m-Xylylenediaminium sulfate: crystal structure and Hirshfeld surface analysis
- Author
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Afef Guesmi, Sofian Gatfaoui, Thierry Roisnel, and Houda Marouani
- Subjects
crystal structure ,m-xylylenediaminium ,sulfate ,hydrogen bonding ,Hirshfeld surface analysis ,fingerprint maps ,Crystallography ,QD901-999 - Abstract
The crystal structure of the title salt {systematic name: [1,3-phenylenebis(methylene)]bis(azanium) sulfate}, C8H14N22+·SO42−, consists of infinite (100) sheets of alternating organic and inorganic entities The m-xylylenediaminium cations are linked to the sulfate anions by N—H...O and asymmetric bifurcated N—H...(O,O) hydrogen bonds, generating a three-dimensional network. A weak C—H...O interaction also occurs. The Hirshfeld surface analysis and the two-dimensional fingerprint maps indicate that the packing is dominated by H...O/O...H and H...H contacts.
- Published
- 2016
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34. trans-2,5-Dimethylpiperazine-1,4-diium bis(perchlorate) dihydrate: crystal structure and Hirshfeld surface analysis
- Author
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Cherifa Ben Mleh, Thierry Roisnel, and Houda Marouani
- Subjects
crystal structure ,piperazine derivative ,molecular salt ,hydrogen bonding ,Hirshfeld surface analysis ,Crystallography ,QD901-999 - Abstract
The asymmetric unit of the title hydrated molecular salt, C6H16N22+·2ClO4−·2H2O, contains a half dication (completed by inversion symmetry), a perchlorate anion and a water molecule. The extended structure consists of infinite chains of formula [(ClO4)H2O]nn− ions extending along the b axis linked by Ow—H...O (w = water) hydrogen bonds. These chains are cross-linked by the dications via N—H...Ow and weak C—H...O hydrogen bonds, thus forming a three-dimensional supramolecular network. Three-dimensional Hirshfeld surface analysis and two-dimensional fingerprint maps reveal that the structure is dominated by H...O/O...H and H...H contacts.
- Published
- 2016
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35. Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship
- Author
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Mohamed Yacine Ameur Messaoud, Ghenia Bentabed-Ababsa, Madani Hedidi, Aïcha Derdour, Floris Chevallier, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Laurent Picot, Valérie Thiéry, Thierry Roisnel, Vincent Dorcet, and Florence Mongin
- Subjects
CH acidity ,indoles ,iodolysis ,mixed lithium–zinc bases ,pyrroles ,Science ,Organic chemistry ,QD241-441 - Abstract
The synthesis of N-arylated pyrroles and indoles is documented, as well as their functionalization by deprotonative metallation using the base in situ prepared from LiTMP and ZnCl2·TMEDA (1/3 equiv). With N-phenylpyrrole and -indole, the reactions were carried out in hexane containing TMEDA which regioselectively afforded the 2-iodo derivatives after subsequent iodolysis. With pyrroles and indoles bearing N-substituents such as 2-thienyl, 3-pyridyl, 4-methoxyphenyl and 4-bromophenyl, the reactions all took place on the substituent, at the position either adjacent to the heteroatom (S, N) or ortho to the heteroatom-containing substituent (OMe, Br). The CH acidities of the substrates were determined in THF solution using the DFT B3LYP method in order to rationalize the experimental results.
- Published
- 2015
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36. Structure cristalline du composé Hg3-xSbx(S+Se)2+xI2-x (x ≃ 0.1)
- Author
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Mohammed Kars, Adrian Gómez Herrero, Thierry Roisnel, Allaoua Rebbah, and L. Carlos Otero-Diáz
- Subjects
crystal structure ,mercury chalcohalide ,coupled substitution ,crankshaft-type ,Crystallography ,QD901-999 - Abstract
Single crystals of the mercury chalcohalide Hg3-xSbx(S+Se)2+xI2-x (x ≃ 0.1) (mercury antimony sulfide selenide iodide), were grown by a chemical transport reaction. The structure contains three independent A (Hg/Sb) atoms; each atom is strongly covalently bonded with two X (Se/S) atoms to form approximately linear X–A–X units. The X–A–X units link to form A4X4 rings, which are combined into infinite crankshaft-type bands running along the [100] direction. Four equatorial E (I/X = Se,S) atoms at relatively long distances complete the distorted octahedral coordination of A (Hg/Sb). The crystal under investigation was twinned by non-merohedry with a refined twin domain fraction of 0.814 (6):0.186 (6). The structure is isotypic with Hg3Se2I2 [Beck & Hedderich (2000). J. Solid State Chem. 151, 73–76], but the current determination reveals a coupled substitution, with partial replacement of Hg+2 by Sb+3, balanced by the equivalent substitution of I−1 by S−2 and Se−2. Bond-valence calculations are consistent with this relative substitution model.
- Published
- 2016
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37. Synthesis, Structures and Chemistry of the Metallaboranes of Group 4–9 with M2B5 Core Having a Cross Cluster M–M Bond
- Author
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Ranjit Bag, Suvam Saha, Rosmita Borthakur, Bijan Mondal, Thierry Roisnel, Vincent Dorcet, Jean-François Halet, and Sundargopal Ghosh
- Subjects
chromaborane ,metallaborane ,mixed-metal cluster ,molybdaborane ,tungstaborane ,Inorganic chemistry ,QD146-197 - Abstract
In an attempt to expand the library of M2B5 bicapped trigonal-bipyramidal clusters with different transition metals, we explored the chemistry of [Cp*WCl4] with metal carbonyls that enabled us to isolate a series of mixed-metal tungstaboranes with an M2{B4M’} {M = W; M’ = Cr(CO)4, Mo(CO)4, W(CO)4} core. The reaction of in situ generated intermediate, obtained from the low temperature reaction of [Cp*WCl4] with an excess of [LiBH4·thf], followed by thermolysis with [M(CO)5·thf] (M = Cr, Mo and W) led to the isolation of the tungstaboranes [(Cp*W)2B4H8M(CO)4], 1⁻3 (1: M = Cr; 2: M = Mo; 3: M = W). In an attempt to replace one of the BH—vertices in M2B5 with other group metal carbonyls, we performed the reaction with [Fe2(CO)9] that led to the isolation of [(Cp*W)2B4H8Fe(CO)3], 4, where Fe(CO)3 replaces a {BH} core unit instead of the {BH} capped vertex. Further, the reaction of [Cp*MoCl4] and [Cr(CO)5·thf] yielded the mixed-metal molybdaborane cluster [(Cp*Mo)2B4H8Cr(CO)4], 5, thereby completing the series with the missing chromium analogue. With 56 cluster valence electrons (cve), all the compounds obey the cluster electron counting rules. Compounds 1⁻5 are analogues to the parent [(Cp*M)2B5H9] (M= Mo and W) that seem to have generated by the replacement of one {BH} vertex from [(Cp*W)2B5H9] or [(Cp*Mo)2B5H9] (in case of 5). All of the compounds have been characterized by various spectroscopic analyses and single crystal X-ray diffraction studies.
- Published
- 2019
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38. From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines
- Author
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Frédéric Lassagne, Timothy Langlais, Elsa Caytan, Emmanuelle Limanton, Ludovic Paquin, Manon Boullard, Coline Courtel, Idriss Curbet, Clément Gédéon, Julien Lebreton, Laurent Picot, Valérie Thiéry, Mohamed Souab, Blandine Baratte, Sandrine Ruchaud, Stéphane Bach, Thierry Roisnel, and Florence Mongin
- Subjects
pyrazine ,deprotometalation ,coupling ,N-arylation ,palladium ,copper ,Organic chemistry ,QD241-441 - Abstract
2,3-Diphenylated quinoxaline, pyrido[2,3-b]pyrazine and 8-bromopyrido[3,4-b]pyrazine were halogenated in deprotometalation-trapping reactions using mixed 2,2,6,6-tetramethyl piperidino-based lithium-zinc combinations in tetrahydrofuran. The 2,3-diphenylated 5-iodo- quinoxaline, 8-iodopyrido[2,3-b]pyrazine and 8-bromo-7-iodopyrido[3,4-b]pyrazine thus obtained were subjected to palladium-catalyzed couplings with arylboronic acids or anilines, and possible subsequent cyclizations to afford the corresponding pyrazino[2,3-a]carbazole, pyrazino[2′,3′:5,6] pyrido[4,3-b]indole and pyrazino[2′,3′:4,5]pyrido[2,3-d]indole, respectively. 8-Iodopyrido[2,3-b] pyrazine was subjected either to a copper-catalyzed C-N bond formation with azoles, or to direct substitution to introduce alkylamino, benzylamino, hydrazine and aryloxy groups at the 8 position. The 8-hydrazino product was converted into aryl hydrazones. Most of the compounds were evaluated for their biological properties (antiproliferative activity in A2058 melanoma cells and disease-relevant kinase inhibition).
- Published
- 2018
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39. Structure cristalline du composé intermétallique Ni18Ge12
- Author
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Mohammed Kars, Adrian Gómez Herrero, Thierry Roisnel, Allaoua Rebbah, and L. Carlos Otero-Diáz
- Subjects
crystal structure ,nickel germanide ,intermetallic compound ,B8-type substructure ,Ge...Ni interactions ,Crystallography ,QD901-999 - Abstract
Single crystals of octadecanickel dodecagermanide were grown by chemical transport reaction. The intermetallic compound crystallizes in a superstructure of the hexagonal NiAs type (B8 type). All atoms in the asymmetric unit lie on special positions except one Ni atom (two Ni atoms have site symmetry -6.. and another one has site symmetry .2. while the Ge atoms have site symmetries 32., m.. and 3..). In the structure, the Ni atoms are arranged in 11- or 13-vertex polyhedra (CN = 11–13). The coordination polyhedra of the Ge atoms are bicapped square antiprisms (CN = 10) or 11-vertex polyhedra (CN = 11). The structure exhibits strong Ge...Ni interactions, but no close Ge...Ge contacts are observed. The Ni atoms with CN = 13 form infinite chains along [001] with an Ni—Ni distance of 2.491 (2) Å.
- Published
- 2015
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40. Crystal structure of 2-(1H-imidazol-3-ium-4-yl)ethanaminium dichloride, a re-determination
- Author
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Samira Louhibi, Imene Belfilali, Leila Boukli-Hacene, and Thierry Roisnel
- Subjects
crystal structure ,histamine ,redetermination ,hydrogen bonding ,Crystallography ,QD901-999 - Abstract
The crystal structure of the title molecular salt, C5H11N3+·2Cl−, was redetermined. In comparison with the previous study [Bonnet et al. (1975). Bull. Soc. Fr. Mineral. Crist. 98, 208–213.], the positions of some H atoms were corrected, allowing a more accurate description of the hydrogen-bonding scheme. In addition, the absolute structure was also determined. The maximum differences in terms of bond lengths and angles between the two determinations are 0.022 Å and 1.43°, respectively. The organic cation display a anti conformation of the protonated amine function and the imidazolium ring. The dihedral angle between the imidazolium plane and the plane through the C—C—N side chain is 29.58 (3)°. In the crystal, the organic cations and Cl− anions are stacked alternatively into layers parallel to (100). N—H...Cl hydrogen bonds between all H atoms of the ammonium group and both N—H groups of the imidazolium ring and the Cl− acceptor anions lead to the linkage of organic and inorganic layers into a three-dimensional network.
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- 2015
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41. Metal (Hg, Pt, Ru) Bisalkynyl Bridge between Tetrathiafulvalene Electrophores and Electronic Interplay
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Morgan Auffray, Antoine Vacher, Thierry Roisnel, and Dominique Lorcy
- Subjects
tetrathiafulvalene ,alkynyl complexes ,ruthenium ,platinum ,mercury ,electrochemistry ,electronic interaction ,Inorganic chemistry ,QD146-197 - Abstract
A series of metal (Hg, Pt, Ru) bis(alkynyl-tetrathiafulvalene) complexes have been investigated to study the electronic interplay between the metal and the tetrathiafulvalene (TTF), as well as between the two peripheral TTF electrophores along the organometallic bridge. Cyclic voltammetry experiments, together with spectro-electrochemical investigations, have shown the electronic effect of the metal center through the linker on redox properties of the TTF, as well as the influence of the length of the conjugated organic linker. These data show that the degree of coupling can be modulated from no coupling with mercury to appreciable electronic coupling between different electrophores with ruthenium.
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- 2018
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42. Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors
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Camille D. Dago, Paul Le Maux, Thierry Roisnel, Christophe Brigaudeau, Yves-Alain Bekro, Olivier Mignen, and Jean-Pierre Bazureau
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pyrazole ,SKF-96365 ,analogues ,resolution ,half-quantities ,SOCE ,B lymphocyte cell ,SOCE inhibitor ,Ca2+ signalling ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) (IC50 25 μM) on the PLP-B lymphocyte cell line. A successful resolution of (±) 1-phenyl-2-(1H-pyrazol-1-yl)ethan-1-ol has been developed by using the method of “half-concentration” in the presence of (+)-(1S)- or (−)-(1R)-CSA.
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- 2018
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43. Crystal structure of 2-(1H-imidazol-4-yl)ethanaminium chloride
- Author
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Imene Belfilali, Siham Yebdri, Samira Louhibi, Leila Boukli-hacene, and Thierry Roisnel
- Subjects
crystal structure ,histamine ,imidazole ,chloride Ion ,protonation ,hydrogen bonding ,Crystallography ,QD901-999 - Abstract
The title molecular salt, C5H10N3+·Cl−, was obtained as by-product in the attempted synthesis of a histamine derivative. The terminal amino group of the starting material is protonated. The Cimidazole—C—C—N(H3)+ group in the cation is in an anti conformation with a torsion angle of 176.22 (10)°. In the crystal, cations and anions are linked via N—H...N and N—H—Cl hydrogen bonds, forming a two-dimensional network parallel to (10-1). A single weak C—H...Cl hydrogen bond completes a three-dimensional network.
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- 2015
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44. Crystal structure of diaqua[5,10,15,20-tetrakis(4-bromophenyl)porphyrinato-κ4N]magnesium
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Nesrine Amiri, Soumaya Nasri, Thierry Roisnel, Gérard Simonneaux, and Habib Nasri
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crystal structure ,magnesium porphyrin complex ,O—H...Br hydrogen bonds ,C—H...Br interactions ,C—H...π interactions ,Crystallography ,QD901-999 - Abstract
The title compound, [Mg(C44H24Br4N4)(H2O)2] or [Mg(TBrPP)(H2O)2], where TBrPP is the 5,10,15,20-tetrakis(4-bromophenyl)porphyrinato ligand, was obtained unintentionally as a by-product of the reaction of the [Mg(TBrPP)] complex with an excess of dimethylglyoxime in dichloromethane. The entire molecule exhibits point group symmetry 4/m. In the asymmetric unit, except for two C atoms of the phenyl ring, all other atoms lie on special positions. The MgII atom is situated at a site with symmetry 4/m, while the N and the C atoms of the porphyrin macrocycle, as well as two C atoms of the phenyl ring and the Br atom lie in the mirror plane containing the porphyrin core. The H atoms of the axially bonded water molecule are incompatible with the fourfold rotation axis and are disordered over two sites. In the crystal, molecules are packed in rows along [001]. Weak intermolecular C—H...π and C—H...Br interactions, as well as O—H...Br hydrogen bonds, stabilize the crystal packing.
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- 2015
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45. K+···Cπ and K+···F Non-Covalent Interactions in π-Functionalized Potassium Fluoroalkoxides
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Sorin-Claudiu Roşca, Hanieh Roueindeji, Vincent Dorcet, Thierry Roisnel, Jean-François Carpentier, and Yann Sarazin
- Subjects
alkoxide ligands ,potassium complexes ,secondary interactions ,potassium–fluorine contacts ,potassium–Cπ interactions ,π ligands ,Inorganic chemistry ,QD146-197 - Abstract
Secondary interactions stabilize coordinatively demanding complexes of s-block metals [...]
- Published
- 2017
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46. Bis(4-aminopyridinium) dichromate(VI)
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Sonia Trabelsi, Thierry Roisnel, Hassouna Dhaouadi, and Houda Marouani
- Subjects
Crystallography ,QD901-999 - Abstract
The asymmetric unit of the title salt, (C5H7N2)2[Cr2O7], contains four independent cations and two independent dichromate anions. The crystal structure consists of discrete dichromate anions with an eclipsed conformation stacked in layers parallel to (010) at y = 1/4 and y = 3/4. These layers are linked via 4-aminopyridinium cations by N—H...O and weak C—H...O hydrogen bonds, forming a three-dimensional supramolecular network. In addition, π–π interactions are present in this structure; the shortest distance separating mean planes through 4-aminopyridinium cations is 3.679 (6) Å.
- Published
- 2014
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47. trans-2,5-Dimethylpiperazine-1,4-diium dinitrate
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Sofian Gatfaoui, Thierry Roisnel, Hassouna Dhaouadi, and Houda Marouani
- Subjects
Crystallography ,QD901-999 - Abstract
In the structure of the title salt, C6H16N22+·2NO3−, the cations are connected to the anions through bifurcated N—H...(O,O) and weak C—H...O hydrogen bonds, generating corrugated layers parallel to the (100) plane. The organic cation is centrosymmetric and the diprotonated piperazine ring adopts a chair conformation, with the methyl groups occupying equatorial positions.
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- 2014
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48. Bis(1-methylpiperazine-1,4-diium) di-μ-bromido-bis[tetrabromidobismuthate(III)] dihydrate
- Author
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Manel Essid, Thierry Roisnel, and Houda Marouani
- Subjects
Crystallography ,QD901-999 - Abstract
In the title hydrated salt, (C5H14N2)2[Bi2Br10]·2H2O, the complete [Bi2Br10]4− bioctahedron is generated by crystallographic inversion symmetry. The diprotonated piperazine ring adopts a chair conformation, with the methyl group occupying an equatorial position. In the crystal, the tetraanions and water molecules are linked by O—H...Br and O—H...(Br,Br) hydrogen bonds to generate [100] chains. The chains are crosslinked by N—H...Br, N—H...O and C—H...Br hydrogen bonds originating from the piperazinediium dications, thereby forming a three-dimensional network.
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- 2014
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49. Dopaminium nitrate
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Sofian Gatfaoui, Houda Marouani, Thierry Roisnel, and Hassouna Dhaouadi
- Subjects
Crystallography ,QD901-999 - Abstract
The asymmetric unit of the title salt [systematic name: 2-(3,4-dihydroxyphenyl)ethanaminium nitrate], C8H12NO2+·NO3−, contains two independent cations and two independent nitrate anions. The crystal structure consists of discrete nitrate ions stacked in layers parallel to (010). These layers are linked via the dopaminium cations by O—H...O, N—H...O and weak C—H...O hydrogen bonds, forming a three-dimensional supramolecular network.
- Published
- 2014
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50. m-Xylylenediaminium dinitrate
- Author
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Sofian Gatfaoui, Hassouna Dhaouadi, Thierry Roisnel, Mohamed Rzaigui, and Houda Marouani
- Subjects
Crystallography ,QD901-999 - Abstract
The asymmetric unit of the title salt, C8H14N22+·2NO3−, contains two independent dications and four independent nitrate anions. The crystal structure consists of discrete nitrate ions, three of which stack in layers parallel to (001) at z = 0 and 0.5. These layers are connected via m-xylylenediaminium dications. The fourth anion is sandwiched by the two independent organic cations in the asymmetric unit. In the crystal, the ions are connected by a large number of bifurcated and non-bifurcated N—H...O(O) hydrogen bonds, forming sheets parallel to (100). These sheets are connected by C—H...O hydrogen bonds, forming a three-dimensional network.
- Published
- 2014
- Full Text
- View/download PDF
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