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5. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes

Published
2023
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8. Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer: Insights From the GastroBenchmark and GASTRODATA databases.

Author

Schneider, Marcel André, Jeesun Kim, Berlth, Felix, Sugita, Yutaka, Grimminger, Peter P., Wijnhoven, Bas P. L., Overtoom, Hidde, Gockel, Ines, Thieme, René, Griffiths, Ewen A., Butterworth, William, Nienhüser, Henrik, Müller, Beat, Crnovrsanin, Nerma, Gero, Daniel, Nickel, Felix, Gisbertz, Suzanne, van Berge Henegouwen, Mark I., Pucher, Philip H., and Khan, Kashuf

Abstract

Objective/Background: Various anastomotic and reconstruction techniques are used for minimally invasive total (miTG) and distal gastrectomy (miDG). Their effects on postoperative morbidity have not been extensively studied. Methods: MiTG and miDG patients were selected from 9356 oncological gastrectomies performed in 2017--2021 in 43 centers. Endpoints included anastomotic leakage (AL) rate and postoperative morbidity tested by multivariable analysis. Results: Three major anastomotic techniques [circular stapled (CS); linear stapled (LS); and hand sewn (HS)], and 3 major bowel reconstruction types [Roux (RX); Billroth I (BI); Billroth II (BII)] were identified in miTG (n= 878) and miDG (n=3334). Postoperative complications, including AL (5.2% vs 1.1%), overall (28.7% vs 16.3%), and major morbidity (15.7% vs 8.2%), as well as 90-day mortality (1.6% vs 0.5%) were higher after miTG compared with miDG. After miTG, the AL rate was higher after CS (4.3%) and HS (7.9%) compared with LS (3.4%). Similarly, major complications (LS: 9.7%, CS: 16.2%, and HS: 12.7%) were lowest after LS. Multivariate analysis confirmed anastomotic technique as a predictive factor for AL, overall, and major complications. In miDG, AL rate (BI: 1.4%, BII 0.8%, and RX 1.2%), overall (BI: 14.5%, BII: 15.0%, and RX: 18.7%), and major morbidity (BI: 7.9%, BII: 9.1%, and RX: 7.2%), and mortality (BI: 0%, BII: 0.1%, and RY: 1.1%%) were not affected by bowel reconstruction. Conclusions: In oncologically suitable situations, miDG should be preferred to miTG, as postoperative morbidity is significantly lower. LS should be a preferred anastomotic technique for miTG in Western Centers. Conversely, bowel reconstruction in DG may be chosen according to the surgeon's preference. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Oncologic Surgery for Lower Gastrointestinal Tumors during Pregnancy: A Literature Review

Author

Plum, Patrick S., Chon, Seung-Hun, Alakus, Hakan, Mehdorn, Matthias, Stelzner, Sigmar, Thieme, René, Kreuser, Nicole, and Gockel, Ines

Abstract

Background:Colorectal cancer (CRC) during pregnancy can be a challenging situation due to the spatial confinement of the tumor with the growing uterus carrying the fetus. It is one of the more common tumor entities occurring in pregnant women, and therefore, it has to be taken into account if “patients describe suspicious” symptoms. Summary:Diagnosis and treatment are complex and require a specialized multidisciplinary team of visceral oncologists with expertise in colorectal surgery, gastrointestinal oncologists, gynecologists, obstetricians, and neonatologists to coordinate the optimal treatment plan with the patient. Multimodal treatment options depend on gestational age and tumor stage. Radical surgical oncologic therapy at the latest possible stage of pregnancy is often the only feasible, potentially curative treatment option. Chemotherapy and radiotherapy should be postponed to the postpartum period, if possible. Neonatological aspects, including the high risk of serious complications for the infant during and after anesthesia for oncologic surgery, such as cerebral hemorrhage, pulmonary hypoplasia, and necrotizing enterocolitis, must always be in the focus when considering the optimal timing of surgery, as well as the prognosis of the mother concerning her tumor. Key Message:Treatment of CRC during pregnancy is based on highly individualized therapeutic decisions rather than on standardized guideline recommendations. Surgical resection via partial colectomy, anterior rectal resections, and abdominoperineal extirpations are feasible. However, it has always to be considered if surgery has to be performed in elective situations or damage control procedures due to emergencies, such as mechanical ileus or perforations with intra-abdominal sepsis.

Published
2025
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13. CRBP-TS - evaluation of a home-based training and health care program for colorectal, breast, and prostate cancer using telemonitoring and self-management: study protocol for a randomized controlled trial

Author

Falz, Roberto, Thieme, René, Tegtbur, Uwe, Bischoff, Christian, Leps, Christian, Hillemanns, Peter, Kohlhaw, Kay, Klempnauer, Jürgen, Lordick, Florian, Stolzenburg, Jens-Uwe, Aktas, Bahriye, Weitz, Jürgen, Bork, Ulrich, Wimberger, Pauline, Thomas, Christian, Biemann, Ronald, Jansen-Winkeln, Boris, Schulze, Antina, Gockel, Ines, and Busse, Martin

Published
2021
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14. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Author

Dong, Jing, Gharahkhani, Puya, Chow, Wong-Ho, Gammon, Marilie D., Liu, Geoffrey, Caldas, Carlos, Wu, Anna H., Ye, Weimin, Onstad, Lynn, Anderson, Lesley A., Bernstein, Leslie, Pharoah, Paul D., Risch, Harvey A., Corley, Douglas A., Fitzgerald, Rebecca C., Iyer, Prasad G., Reid, Brian J., Lagergren, Jesper, Shaheen, Nicholas J., Vaughan, Thomas L., MacGregor, Stuart, Love, Sharon, Palles, Claire, Tomlinson, Ian, Gockel, Ines, May, Andrea, Gerges, Christian, Anders, Mario, Böhmer, Anne C., Becker, Jessica, Kreuser, Nicole, Thieme, Rene, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Schmidt, Claudia, Izbicki, Jakob R., Hölscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Mayershofer, Rupert, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M., Moebus, Susanne, Knapp, Michael, Peters, Wilbert H.M., Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Jankowski, Janusz, Schumacher, Johannes, Neale, Rachel E., Whiteman, David C., and Thrift, Aaron P.

Published
2019
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17. Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation.

Author

Urbiola-Salvador, Víctor, Jabłońska, Agnieszka, Miroszewska, Dominika, Kamysz, Weronika, Duzowska, Katarzyna, Drężek-Chyła, Kinga, Baber, Ronny, Thieme, René, Gockel, Ines, Zdrenka, Marek, Śrutek, Ewa, Szylberg, Łukasz, Jankowski, Michał, Bała, Dariusz, Zegarski, Wojciech, Nowikiewicz, Tomasz, Makarewicz, Wojciech, Adamczyk, Agnieszka, Ambicka, Aleksandra, and Przewoźnik, Marcin

Subjects
COLORECTAL cancer, TUMOR markers, MASS spectrometry, PROTEOMICS, CERULOPLASMIN, APOLIPOPROTEIN C, CHOLESTEROL metabolism
Abstract

Background: Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore, non-invasive, cost-effective, and accurate alternatives are urgently needed. Objective and design: This retrospective multi-center plasma proteomics study was performed to identify potential blood-based biomarkers in 36 CRC patients and 26 healthy volunteers by high-resolution mass spectrometry proteomics followed by the validation in an independent CRC cohort (60 CRC patients and 44 healthy subjects) of identified selected biomarkers. Results: Among the 322 identified plasma proteins, 37 were changed between CRC patients and healthy volunteers and were associated with the complement cascade, cholesterol metabolism, and SERPIN family members. Increased levels in CRC patients of the complement proteins C1QB, C4B, and C5 as well as pro-inflammatory proteins, lipopolysaccharide-binding protein (LBP) and serum amyloid A4, constitutive (SAA4) were revealed for first time. Importantly, increased level of C5 was verified in an independent validation CRC cohort. Increased C4B and C8A levels were correlated with cancer-associated inflammation and CRC progression, while cancer-associated inflammation was linked to the acute-phase reactant leucine-rich alpha-2-glycoprotein 1 (LRG1) and ceruloplasmin. Moreover, a 4-protein signature including C4B, C8A, apolipoprotein C2 (APO) C2, and immunoglobulin heavy constant gamma 2 was changed between early and late CRC stages. Conclusion: Our results suggest that C5 could be a potential biomarker for CRC diagnosis. Further validation studies will aid the application of these new potential biomarkers to improve CRC diagnosis and patient care. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model

Author

Rousseau-Ralliard, Delphine, Couturier-Tarrade, Anne, Thieme, René, Brat, Roselyne, Rolland, Audrey, Boileau, Pascal, Aubrière, Marie-Christine, Daniel, Nathalie, Dahirel, Michèle, Derisoud, Emilie, Fournier, Natalie, Schindler, Maria, Duranthon, Véronique, Fischer, Bernd, Santos, Anne Navarrete, and Chavatte-Palmer, Pascale

Published
2019
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20. The Long-Term Effect of the Periconception Period on the Embryo’s Epigenetic Profile and Phenotype: The Role of Maternal Disease Such as Diabetes and How the Effect Is Mediated (Example from a Rabbit Model)

Author

Fischer, Bernd, Schindler, Maria, Mareike Pendzialek, S., Gürke, Jacqueline, Haucke, Elisa, Grybel, Katarzyna Joanna, Thieme, René, Santos, Anne Navarrete, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Fazeli, Alireza, editor, and Holt, William V., editor

Published
2017
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22. Descriptive review of current practices and prognostic factors in patients with ovarian cancer treated by pressurized intraperitoneal aerosol chemotherapy (PIPAC): a multicentric, retrospective, cohort of 234 patients

Author

Kefleyesus, Amaniel, primary, Bhatt, Aditi, additional, Escayola, Cecilia, additional, Khomyakov, Vladimir, additional, Hübner, Martin, additional, Reymond, Marc A., additional, Thieme, René, additional, Sgarbura, Olivia, additional, Willaert, Wouter, additional, Ceelen, Wim, additional, Di Giorgio, Andrea, additional, Vizzielli, Giuseppe, additional, Glehen, Olivier, additional, Robella, Manuela, additional, and Bakrin, Naoual, additional

Published
2023
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23. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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24. Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice

Author

Engels, Géraldine, Hierweger, Alexandra Maximiliane, Hoffmann, Julia, Thieme, René, Thiele, Swantje, Bertram, Stephanie, Dreier, Carola, Resa-Infante, Patricia, Jacobsen, Henning, Thiele, Kristin, Alawi, Malik, Indenbirken, Daniela, Grundhoff, Adam, Siebels, Svenja, Fischer, Nicole, Stojanovska, Violeta, Muzzio, Damián, Jensen, Federico, Karimi, Khalil, Mittrücker, Hans-Willi, Arck, Petra Clara, and Gabriel, Gülsah

Published
2017
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25. Defining benchmarks for total and distal gastrectomy: global multicentre analysis.

Author

Schneider, Marcel André, Kim, Jeesun, Berlth, Felix, Sugita, Yutaka, Grimminger, Peter P, Sano, Takeshi, Rosati, Riccardo, Baiocchi, Gian Luca, Bencivenga, Maria, De Manzoni, Giovanni, Nunobe, Souya, Yang, Han-Kwang, Gutschow, Christian Alexander, Wijnhoven, Bas P L, Overtoom, Hidde, Gockel, Ines, Thieme, René, Griffiths, Ewen A, Butterworth, William, and Nienhüser, Henrik

Subjects
LYMPHADENECTOMY, GASTRIC bypass, GASTRECTOMY, SURGICAL complications, CANCER patients, SURGERY, MEDICAL personnel
Abstract

This document provides a list of references to studies and articles that focus on surgical outcomes and benchmarking in various areas of surgery, including esophagogastric cancer surgery, gastrectomy for cancer, liver transplantation, and bariatric surgery. The studies aim to establish benchmarks and evaluate the quality of surgical interventions, with a particular emphasis on measuring surgical morbidity and complications. The articles offer insights into different surgical techniques, outcomes, and risk factors associated with different surgical procedures. [Extracted from the article]

Published
2024
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27. Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers.

Author

Chuang Yang, Plum, Patrick Sven, Gockel, Ines, and Thieme, René

Subjects
AURORA kinases, ARACHIDONIC acid, TUMOR microenvironment, CELL cycle, PANCREATIC cancer, PANCREATIC intraepithelial neoplasia, PANCREATIC tumors
Abstract

Background: Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and tumor progression. However, its prognostic significance across diverse cancer types remains relatively unexplored. Methods: We conducted a comprehensive analysis of AURKA expression in various cancers using data from The Cancer Genome Atlas, Genotype-Tissue Expression, and The Human Protein Atlas databases. Our investigation encompassed an exploration of the associations between AURKA expression and clinical characteristics, shedding light on potential functional roles of AURKA. Additionally, we delved into the relationship between AURKA and the tumor microenvironment. To substantiate the role of AURKA, we carried out in vitro experiments in esophageal adenocarcinoma (EAC), prostate cancer (PRAD), and pancreatic cancer (PAAD) cells. Results: Our analysis revealed that AURKA is prominently overexpressed in a majority of the cancer types under investigation. Elevated AURKA expression correlated closely with poorer prognosis and advanced tumor stages. AURKA was found to be associated with key pathways involved in the cell cycle and arachidonic acid metabolism. Moreover, AURKA expression exhibited significant correlations with immunoregulatory genes and immune cell profiles. Notably, in vitro experiments demonstrated that silencing AURKA expression resulted in reduced cell viability in EAC, PRAD, and PAAD cells, as well as a decrease in clone formation, cell cycle elongation, diminished cell invasion and reduced spheroid size in EAC cells (OE33 and OE19). Conclusion: Our study elucidates the oncogenic role of AURKA and underscores its prognostic value across a spectrum of cancers, including EAC. These findings suggest that AURKA holds promise as a predictive biomarker for EAC and various other tumor types. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Alternative intraoperative optical imaging modalities for fluorescence angiography in gastrointestinal surgery: spectral imaging and imaging photoplethysmography

Author

Chalopin, Claire, primary, Pfahl, Annekatrin, additional, Köhler, Hannes, additional, Knospe, Luise, additional, Maktabi, Marianne, additional, Unger, Michael, additional, Jansen-Winkeln, Boris, additional, Thieme, René, additional, Moulla, Yusef, additional, Mehdorn, Matthias, additional, Sucher, Robert, additional, Neumuth, Thomas, additional, Gockel, Ines, additional, and Melzer, Andreas, additional

Published
2023
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32. Prävention gastrointestinaler Tumoren

Author

Teufel, Andreas, additional, Quante, Michael, additional, Kandulski, Arne, additional, Hirth, Michael, additional, Zhan, Tianzuo, additional, Eckardt, Maximilian, additional, Thieme, René, additional, Schulte, Nadine, additional, Belle, Sebastian, additional, Wiest, Isabella, additional, Reißfelder, Christoph, additional, Riemann, Jürgen F., additional, Schlitt, Hans J., additional, Gockel, Ines, additional, Malfertheiner, Peter, additional, and Ebert, Matthias P., additional

Published
2022
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38. The Long-Term Effect of the Periconception Period on the Embryo’s Epigenetic Profile and Phenotype: The Role of Maternal Disease Such as Diabetes and How the Effect Is Mediated (Example from a Rabbit Model)

Author

Fischer, Bernd, primary, Schindler, Maria, additional, Mareike Pendzialek, S., additional, Gürke, Jacqueline, additional, Haucke, Elisa, additional, Grybel, Katarzyna Joanna, additional, Thieme, René, additional, and Santos, Anne Navarrete, additional

Published
2017
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43. New Intraoperative Imaging Tools and Image-Guided Surgery in Gastric Cancer Surgery

Author

Knospe, Luise, Gockel, Ines, Jansen-Winkeln, Boris, Thieme, René, Niebisch, Stefan, Moulla, Yusef, Stelzner, Sigmar, Lyros, Orestis, Diana, Michele, Marescaux, Jacques, Chalopin, Claire, Köhler, Hannes, Pfahl, Annekatrin, Maktabi, Marianne, Park, Ji-Hyeon, Yang, Han-Kwang, Knospe, Luise, Gockel, Ines, Jansen-Winkeln, Boris, Thieme, René, Niebisch, Stefan, Moulla, Yusef, Stelzner, Sigmar, Lyros, Orestis, Diana, Michele, Marescaux, Jacques, Chalopin, Claire, Köhler, Hannes, Pfahl, Annekatrin, Maktabi, Marianne, Park, Ji-Hyeon, and Yang, Han-Kwang

Abstract

Innovations and new advancements in intraoperative real-time imaging have gained significant importance in the field of gastric cancer surgery in the recent past. Currently, the most promising procedures include indocyanine green fluorescence imaging (ICG-FI) and hyperspectral imaging or multispectral imaging (HSI, MSI). ICG-FI is utilized in a broad range of clinical applications, e.g., assessment of perfusion or lymphatic drainage, and additional implementations are currently investigated. HSI is still in the experimental phase and its value and clinical relevance require further evaluation, but initial studies have shown a successful application in perfusion assessment, and prospects concerning non-invasive tissue and tumor classification are promising. The application of machine learning and artificial intelligence technologies might enable an automatic evaluation of the acquired image data in the future. Both methods facilitate the accurate visualization of tissue characteristics that are initially indistinguishable for the human eye. By aiding surgeons in optimizing the surgical procedure, image-guided surgery can contribute to the oncologic safety and reduction of complications in gastric cancer surgery and recent advances hold promise for the application of HSI in intraoperative tissue diagnostics.

Published
2022

44. New Intraoperative Imaging Tools and Image-Guided Surgery in Gastric Cancer Surgery

Author

Knospe, Luise, primary, Gockel, Ines, additional, Jansen-Winkeln, Boris, additional, Thieme, René, additional, Niebisch, Stefan, additional, Moulla, Yusef, additional, Stelzner, Sigmar, additional, Lyros, Orestis, additional, Diana, Michele, additional, Marescaux, Jacques, additional, Chalopin, Claire, additional, Köhler, Hannes, additional, Pfahl, Annekatrin, additional, Maktabi, Marianne, additional, Park, Ji-Hyeon, additional, and Yang, Han-Kwang, additional

Published
2022
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46. Characterization of Total RNA, CD44, FASN, and PTEN mRNAs from Extracellular Vesicles as Biomarkers in Gastric Cancer Patients

Author

Rhode, Philipp, primary, Mehdorn, Matthias, additional, Lyros, Orestis, additional, Kahlert, Christoph, additional, Kurth, Thomas, additional, Venus, Tom, additional, Schierle, Katrin, additional, Estrela-Lopis, Irina, additional, Jansen-Winkeln, Boris, additional, Lordick, Florian, additional, Gockel, Ines, additional, and Thieme, René, additional

Published
2021
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47. Retroperitoneal space-occupying lesion with displacement of the inferior vena cava

Author

Niebisch, Stefan, Staab, Holger, Ullrich, Sebastian, Hoffmann, Karl-Titus, Sabri, Osama, Thieme, René, Schierle, Katrin, Wittekind, Christian, and Gockel, Ines

Subjects
Preoperative biopsy, Surgical strategy, Retroperitoneal space-occupying soft-tissue tumor, Imaging modalities, Retroperitoneal schwannoma, Article
Abstract

Highlights • Exact preoperative diagnosis and surgery of retroperitoneal schwannoma (RS) is sophisticated. • Due to heterogeneity of the entity, preoperative negative biopsy does not exclude malignancy. • A curative (R0) resection must be achieved in order to avoid local recurrence, always under consideration of multivisceral resections., Introduction The differential diagnosis and therapy of retroperitoneal masses suspicious for soft tissue tumors remains difficult and needs individual decisions as to the best management of patients. We report an unusual case of retroperitoneal schwannoma (RS). Presentation of case We report on a 57-year-old female patient with a retroperitoneal space-occupying lesion with displacement, but no infiltration of surrounding vessels, especially the inferior vena cava. As presence of malignancy could not be completely excluded by imaging and biopsy, we performed an open resection of the tumor with plastic reconstruction of the right renal vein. Curative resection of the tumor could be achieved and benign RS verified. Discussion Preoperative work-up, including a broad spectrum of differential diagnoses, and consecutive appropriate surgical resection are challenging. Characteristic features of the pre-therapeutic diagnostics of retroperitoneal schwannomas are discussed and differential diagnostic considerations as well as surgical therapeutic options are outlined. Conclusion Deeper understanding of retroperitoneal schwannomas gained from preoperative radiologic diagnostics may serve to underline the need for targeted biopsy. This and its histopathological examination necessitate expert interventional radiologists and pathologists. Thus, even the pre-therapeutic diagnostic management should be performed in a specialized center. If doubts remain regarding the entity of the retroperitoneal lesion and findings are still controversial after thorough assessment, surgical oncologic resection represents the therapy of choice, if the surgical risk is adequate.

Published
2019

48. Nrf2/Keap1-Pathway Activation and Reduced Susceptibility to Chemotherapy Treatment by Acidification in Esophageal Adenocarcinoma Cells

Author

Storz, Lucie, Walther, Philipp, Chemnitzer, Olga, Lyros, Orestis, Niebisch, Stefan, Mehdorn, Matthias, Jansen-Winkeln, Boris, Moulla, Yusef, Büch, Thomas, Gockel, Ines, and Thieme, René

Subjects
gastroesophageal reflux disease (GERD), Barrett’s esophagus, esophageal adenocarcinoma, chemotherapy, inflammation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ddc:610, Article, RC254-282, digestive system diseases
Abstract

Simple Summary Inflammation caused by acidic reflux contributes to disease progression in Barrett’s esophagus. Little is known, whether esophageal cancer cells are influenced by acidic reflux and whether reflux influences cancer cell physiology, targeting the Nrf2/Kepa1- and the NFκB-pathway. The understanding mechanisms of the acidic susceptibility in cells from advanced stages of Barrett’s esophagus will provide further evidence, whether it should be prevented during chemotherapy for EAC treatment. Abstract Chronic acid reflux causes cellular damage and inflammation in the lower esophagus. Due to these irritating insults, the squamous epithelium is replaced by metaplastic epithelium, which is a risk factor for the development of esophageal adenocarcinoma (EAC). In this study, we investigated the acid susceptibility in a Barrett’s cell culture in vitro model, using six cell lines, derived from squamous epithelium (EPC1 and EPC2), metaplasia (CP-A), dysplasia (CP-B), and EAC (OE33 and OE19) cells. Cells exposed to acidic pH showed a decreased viability dependent on time, pH, and progression status in the Barrett’s sequence, with the highest acid susceptibility in the squamous epithelium (EPC1 and EPC2), and the lowest in EAC cells. Acid pulsing was accompanied with an activation of the Nrf2/Keap1- and the NFκB-pathway, resulting in an increased expression of HO1—independent of the cellular context. OE33 showed a decreased responsiveness towards 5-FU, when the cells were grown in acidic conditions (pH 6 and pH 5.5). Our findings suggest a strong damage of squamous epithelium by gastroesophageal reflux, while Barrett’s dysplasia and EAC cells apparently exert acid-protective features, which lead to a cellular resistance against acid reflux.

Published
2021
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