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1. List of contributors

Author

Adams, John S., primary, Amrein, Karin, additional, Anderson, Paul H., additional, Arnold, Leggy A., additional, Arora, Juhi, additional, Artusa, Patricio, additional, Ascherio, Alberto, additional, Asmussen, Niels C., additional, Astier, Anne L., additional, Bak, Min Ji, additional, Bauerle, Kevin T., additional, Belorusova, Anna Y., additional, Benkusky, Nancy A., additional, Bernal-Mizrachi, Carlos, additional, Bhattoa, Harjit P., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil C., additional, Bischoff-Ferrari, Heike A., additional, Bishop, Charles W., additional, Blomberg Jensen, Martin, additional, Boisen, Ida Marie, additional, Boucher, Barbara J., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Bradford, Dana, additional, Brancatella, Alessandro, additional, Buburuzan, Laura, additional, Burne, Thomas H.J., additional, Buschittari, Damien, additional, Calkins, Hannah, additional, Calvo, Mona S., additional, Camargo, Carlos A., additional, Campbell, Moray J., additional, Cantorna, Margherita T., additional, Cappellani, Daniele, additional, Carlberg, Carsten, additional, Carmeliet, Geert, additional, Cashman, Kevin D., additional, Ceglia, Lisa, additional, Cetani, Filomena, additional, Chang, Wenhan, additional, Cheadle, Charlotte, additional, Chou, Sharon H., additional, Christakos, Sylvia, additional, Christopher, Kenneth B., additional, Chu, Emily Y., additional, Chun, Rene F., additional, Cleal, Jane K., additional, Cobice, Diego F., additional, Cooper, Cyrus, additional, Coort, Susan L.M., additional, Cui, Xiaoying, additional, Curtis, Elizabeth M., additional, Danilenko, Michael, additional, Darling, Andrea L., additional, David Roodman, G., additional, Dawson-Hughes, Bess, additional, de Jongh, Renate, additional, Demay, Marie B., additional, Dennison, Elaine M., additional, Dixon, Katie M., additional, Dong, Bingning, additional, Doroudi, Maryam, additional, Dusso, Adriana, additional, Dvorzhinskiy, Aleksey, additional, Ebeling, Peter R., additional, Erben, Reinhold G., additional, Evelo, Chris T.A., additional, Eyles, Darryl, additional, Feldman, David, additional, Ferrer-Mayorga, Gemma, additional, Fleet, James C., additional, Forcellati, Marianela, additional, Foster, Brian L., additional, Gafni, Rachel I., additional, Gayan-Ramirez, Ghislaine, additional, Giovannucci, Edward, additional, Girgis, Christian M., additional, Glencross, Drew A., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goldfarb, David S., additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Grant, William B., additional, Groves, Natalie J., additional, Gysemans, Conny, additional, Harrison, Stephanie, additional, Harvey, Nicholas C., additional, Haseltine, Katherine, additional, Hawrylowicz, Catherine M., additional, Hayes, Colleen E., additional, Heckel, John E., additional, Hershberger, Pamela A., additional, Hewison, Martin, additional, Högler, Wolfgang, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Holt, Rune, additional, Hujoel, Philippe P., additional, Hyppönen, Elina, additional, Ismailova, Aiten, additional, Jablonski, Nina G., additional, Jakobsen, Jette, additional, Janssens, Wim, additional, Jeffery, Louisa, additional, Jenkinson, Carl, additional, Jensen, Marie Bagge, additional, Jetten, Anton M., additional, Jiang, Heng, additional, Johnson, Candace S., additional, Jones, Glenville, additional, Jones, Kerry S., additional, Jüppner, Harald, additional, Kalia, Vandana, additional, Kallay, Enikö, additional, Karapalis, Andrew C., additional, Kaufmann, Martin, additional, Kiely, Mairead, additional, Kim, Hanseul, additional, Kim, Tiffany Y., additional, Kojima, Hiroyuki, additional, Kooij, Ireen, additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krieger, Kirsten, additional, Kritmetapak, Kittrawee, additional, Krueger, Diane C., additional, Kumar, Rajiv, additional, Kurihara, Noriyoshi, additional, Lane, Joseph M., additional, Lanham-New, Susan A., additional, Latic, Nejla, additional, LeBoff, Meryl S., additional, Lee, Maija B., additional, Lee, Seong Min, additional, Levine, Michael A., additional, Lewis, Richard, additional, Lewis, Rohan M., additional, Li, Wei, additional, Li, Yan Chun, additional, Lincoln, Matthew R., additional, Lips, Paul, additional, Lisse, Thomas S., additional, Liu, Eva S., additional, López de Maturana, Evangelina, additional, Lugg, Sebastian T., additional, Machado, Christopher J., additional, Maes, Karen, additional, Maestro, Miguel A., additional, Malats, Núria, additional, Malloy, Peter J., additional, Manousaki, Despoina, additional, Marcinkowska, Ewa, additional, Marcocci, Claudio, additional, Martens, Pieter-Jan, additional, Martineau, Adrian R., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Mayne, Phoebe, additional, McGrath, John J., additional, Mehta, Mansi, additional, Mellanby, Richard John, additional, Merchant, Nadia, additional, Meyer, Mark B., additional, Miao, Dengshun, additional, Moon, Rebecca J., additional, Mortensen, Li Juel, additional, Motlaghzadeh, Yasaman, additional, Munger, Kassandra L., additional, Muñoz, Alberto, additional, Nakamichi, Yuko, additional, Narvaez, Carmen J., additional, Nikiphorou, Elena, additional, Nonn, Larisa, additional, Pal, Lubna, additional, Parekh, Dhruv, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Pilz, Stefan, additional, Pittas, Anastassios G., additional, Pludowski, Pawel, additional, Prosser, David E., additional, Pullagura, Sri Ramulu N., additional, Raphael, Joseph, additional, Rauz, Saaeha, additional, Raza, Karim, additional, Real, Francisco X., additional, Reichrath, Jörg, additional, Richards, J. Brent, additional, Rivadeneira, Fernando, additional, Rochel, Natacha, additional, Roizen, Jeffrey D., additional, Ryan, Brittany A., additional, Sarkar, Surojit, additional, Sarmadi, Fatemeh, additional, Schafer, Anne L., additional, Schepelmann, Martin, additional, Schoenmakers, Inez, additional, Schuit, Frans, additional, Schwartz, Zvi, additional, Scott, Kayla M., additional, Sellmeyer, Deborah E., additional, Sempos, Christopher T., additional, Sepiashvili, Lusia, additional, Seshadri, Mukund, additional, Shane, Elizabeth, additional, Shaurova, Tatiana, additional, Shieh, Albert, additional, Shui, Irene, additional, Singh, Ravinder J., additional, Slominski, Andrzej T., additional, Smith, Karl W., additional, St-Arnaud, René, additional, Stein, Emily M., additional, Studzinski, George P., additional, Suda, Tatsuo, additional, Takahashi, Naoyuki, additional, Taylor, Hugh S., additional, Tebben, Peter J., additional, Thacher, Tom D., additional, Thandrayen, Kebashni, additional, Thickett, David R., additional, Tiosano, Dov, additional, Trajanoska, Katerina, additional, Tu, Chia-Ling, additional, Tuckey, Robert C., additional, Tutaworn, Teerapat, additional, Udagawa, Nobuyuki, additional, Uday, Suma, additional, Unnanuntana, Aasis, additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Schoor, Natasja, additional, Verlinden, Lieve, additional, Vieth, Reinhold, additional, Vimaleswaran, Karina S., additional, Wagner, Carol L., additional, Wallace, Graham R., additional, Weaver, Connie M., additional, Webb, Daniel A., additional, Welsh, JoEllen, additional, White, John H., additional, Whiting, Susan J., additional, Williams, Emma L., additional, Yahyavi, Sam Kafai, additional, Yamamoto, Keiko, additional, Yates, Clayton, additional, Zagorac, Sladjana, additional, Zhang, Rong Mei, additional, Zhao, Hengguang, additional, Zhou, Ang, additional, and Zittermann, Armin, additional

Published
2024
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4. Real-world evaluation of rapid and laboratory-free COVID-19 triage for emergency care: external validation and pilot deployment of artificial intelligence driven screening

Author

Watson, Adam, Bhargav, Akshay, Tough, Alex, Rogers, Alice, Shaikh, Ayisha, Valensise, Carolina, Lee, Charlotte, Otasowie, Claire, Metcalfe, David, Agarwal, Ekta, Zareh, Elham, Thangaraj, Evelyn, Pickles, Florence, Kelly, Gabriella, Tadikamalla, Gayatri, Shaw, George, Tong, Heather, Davies, Hettie, Bahra, Jasdeep, Morgan, Jessica, Wilson, Joe, Cutteridge, Joseph, O'Byrne, Katherine, Farache Trajano, Luiza, Oliver, Madeleine, Pikoula, Maria, Mendoza, Maya, Keevil, Melissa, Faisal, Muhammad, Dole, Natasha, Deal, Oscar, Conway-Jones, Rebecca, Sattar, Shajeel, Kundoor, Sneha, Shah, Sumaiyah, Muthusami, Vani, Soltan, Andrew A S, Yang, Jenny, Pattanshetty, Ravi, Novak, Alex, Yang, Yang, Rohanian, Omid, Beer, Sally, Soltan, Marina A, Thickett, David R, Fairhead, Rory, Zhu, Tingting, Eyre, David W, and Clifton, David A

Published
2022
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6. Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

Author

Williams, Bryan, Turner, Rebecca, Libri, Vincenzo, Mussai, Francis, Middleton, Gary, Bowden, Sarah, Bangash, Mansoor, Gao-Smith, Fang, Patel, Jaimin, Sapey, Elizabeth, Thomas, Mark, Coles, Mark, Watkinson, Peter, Rahman, Naj, Angus, Brian, Mentzer, Alexander J., Novak, Alex, Feldman, Marc, Richter, Alex, Faustini, Sian, Bathurst, Camilla, Van de Wiel, Joseph, Mee, Susie, James, Karen, Rahman, Bushra, Turner, Karen, Hill, Adam, Gordon, Anthony, Yap, Christina, Matthay, Michael, McAuley, Danny, Hall, Andrew, Dark, Paul, McMichael, Andrew, Fisher, Benjamin A, Veenith, Tonny, Slade, Daniel, Gaskell, Charlotte, Rowland, Matthew, Whitehouse, Tony, Scriven, James, Parekh, Dhruv, Balasubramaniam, Madhu S, Cooke, Graham, Morley, Nick, Gabriel, Zoe, Wise, Matthew P, Porter, Joanna, McShane, Helen, Ho, Ling-Pei, Newsome, Philip N, Rowe, Anna, Sharpe, Rowena, Thickett, David R, Bion, Julian, Gates, Simon, Richards, Duncan, and Kearns, Pamela

Published
2022
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10. Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model

Author

Ahmad, Saira, primary, Wrennall, Joe A., additional, Goriounova, Alexandra S., additional, Sekhri, Malika, additional, Iskarpatyoti, Jason A., additional, Ghosh, Arunava, additional, Abdelwahab, Sabri H., additional, Voeller, Alexis, additional, Rai, Mani, additional, Mahida, Rahul Y., additional, Krajewski, Krzysztof, additional, Ignar, Diane M., additional, Greenbaum, Alon, additional, Moran, Timothy P., additional, Tilley, Stephen L., additional, Thickett, David R., additional, Sassano, M. Flori, additional, and Tarran, Robert, additional

Published
2024
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11. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation

Author

Moazed, Farzad, Burnham, Ellen L, Vandivier, R William, O'Kane, Cecilia M, Shyamsundar, Murali, Hamid, Umar, Abbott, Jason, Thickett, David R, Matthay, Michael A, McAuley, Daniel F, and Calfee, Carolyn S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Acute Respiratory Distress Syndrome, Tobacco, Lung, Prevention, Tobacco Smoke and Health, Rare Diseases, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Good Health and Well Being, Administration, Inhalation, Adult, Biomarkers, Bronchoalveolar Lavage, Capillary Permeability, Female, Humans, Inflammation, Inflammation Mediators, Lipopolysaccharides, Male, Pulmonary Alveoli, Pulmonary Surfactant-Associated Protein D, Respiratory Distress Syndrome, Smoking, Vascular Endothelial Growth Factor A, ARDS, Tobacco and the lung, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleCigarette smoke exposure is associated with an increased risk of the acute respiratory distress syndrome (ARDS); however, the mechanisms underlying this relationship remain largely unknown.ObjectiveTo assess pathways of lung injury and inflammation in smokers and non-smokers with and without lipopolysaccharide (LPS) inhalation using established biomarkers.MethodsWe measured plasma and bronchoalveolar lavage (BAL) biomarkers of inflammation and lung injury in smokers and non-smokers in two distinct cohorts of healthy volunteers, one unstimulated (n=20) and one undergoing 50 μg LPS inhalation (n=30).Measurements and main resultsAfter LPS inhalation, cigarette smokers had increased alveolar-capillary membrane permeability as measured by BAL total protein, compared with non-smokers (median 274 vs 208 μg/mL, p=0.04). Smokers had exaggerated inflammation compared with non-smokers, with increased BAL interleukin-1β (p=0.002), neutrophils (p=0.02), plasma interleukin-8 (p=0.003), and plasma matrix metalloproteinase-8 (p=0.006). Alveolar epithelial injury after LPS was more severe in smokers than non-smokers, with increased plasma (p=0.04) and decreased BAL (p=0.02) surfactant protein D. Finally, smokers had decreased BAL vascular endothelial growth factor (VEGF) (p

Published
2016

16. A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury: A randomised, placebo-controlled pilot study

Author

Ryan, James, Bayliffe, Andrew I., McAuley, Daniel F., Yeung, Joyce, Thickett, David R., Howells, Phillip A., O’Donnell, Ciara, Vassallo, Arlette M., Wright, Tracey J., McKie, Elizabeth, Hardes, Kelly, Summers, Charlotte, Shields, Martin O., Powley, William, Wilson, Robert, Lazaar, Aili L., Fowler, Andrew, and Perkins, Gavin D.

Published
2020
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17. Scalable federated learning for emergency care using low cost microcomputing: Real-world, privacy preserving development and evaluation of a COVID-19 screening test in UK hospitals

Author

Soltan, Andrew A.S., primary, Thakur, Anshul, additional, Yang, Jenny, additional, Chauhan, Anoop, additional, D'Cruz, Leon G, additional, Dickson, Phillip, additional, Soltan, Marina A, additional, Thickett, David R, additional, Eyre, David W, additional, Zhu, Tingting, additional, and Clifton, David A, additional

Published
2023
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18. Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Author

Mahida, Rahul Y., primary, Lax, Siân, additional, Bassford, Christopher R., additional, Scott, Aaron, additional, Parekh, Dhruv, additional, Hardy, Rowan S., additional, Naidu, Babu, additional, Matthay, Michael A., additional, Stewart, Paul M., additional, Cooper, Mark C., additional, Perkins, Gavin D., additional, and Thickett, David R., additional

Published
2023
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20. Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness

Author

Scott, Jonathan, Harris, Graham J., Pinder, Emma M., Macfarlane, James G., Hellyer, Thomas P., Rostron, Anthony J., Conway Morris, Andrew, Thickett, David R., Perkins, Gavin D., McAuley, Daniel F., Widdrington, John D., Wiscombe, Sarah, Baudouin, Simon V., Roy, Alistair I., Linnett, Vanessa C., Wright, Stephen E., Ruchaud-Sparagano, Marie-Hélène, and Simpson, A. John

Published
2016
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22. Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

Author

Stewart, Iain, primary, Jacob, Joseph, additional, George, Peter M., additional, Molyneaux, Philip L., additional, Porter, Joanna C., additional, Allen, Richard J., additional, Aslani, Shahab, additional, Baillie, J. Kenneth, additional, Barratt, Shaney L., additional, Beirne, Paul, additional, Bianchi, Stephen M., additional, Blaikley, John F., additional, Chalmers, James D., additional, Chambers, Rachel C., additional, Chadhuri, Nazia, additional, Coleman, Christopher, additional, Collier, Guilhem, additional, Denneny, Emma K., additional, Docherty, Annemarie, additional, Elneima, Omer, additional, Evans, Rachael A., additional, Fabbri, Laura, additional, Gibbons, Michael A., additional, Gleeson, Fergus V., additional, Gooptu, Bibek, additional, Greening, Neil J., additional, Guio, Beatriz Guillen, additional, Hall, Ian P., additional, Hanley, Neil A., additional, Harris, Victoria, additional, Harrison, Ewen M., additional, Heightman, Melissa, additional, Hillman, Toby E., additional, Horsley, Alex, additional, Houchen-Wolloff, Linzy, additional, Jarrold, Ian, additional, Johnson, Simon R., additional, Jones, Mark G., additional, Khan, Fasihul, additional, Lawson, Rod, additional, Leavy, Olivia, additional, Lone, Nazir, additional, Marks, Michael, additional, McAuley, Hamish, additional, Mehta, Puja, additional, Parekh, Dhruv, additional, Hanley, Karen Piper, additional, Platé, Manuela, additional, Pearl, John, additional, Poinasamy, Krisnah, additional, Quint, Jennifer K., additional, Raman, Betty, additional, Richardson, Matthew, additional, Rivera-Ortega, Pilar, additional, Saunders, Laura, additional, Saunders, Ruth, additional, Semple, Malcolm G., additional, Sereno, Marco, additional, Shikotra, Aarti, additional, Simpson, A. John, additional, Singapuri, Amisha, additional, Smith, David J. F., additional, Spears, Mark, additional, Spencer, Lisa G., additional, Stanel, Stefan, additional, Thickett, David R., additional, Thompson, A. A. Roger, additional, Thorpe, Mathew, additional, Walsh, Simon L. F., additional, Walker, Samantha, additional, Weatherley, Nicholas David, additional, Weeks, Mark E., additional, Wild, Jim M., additional, Wootton, Dan G., additional, Brightling, Chris E., additional, Ho, Ling-Pei, additional, Wain, Louise V., additional, and Jenkins, Gisli R., additional

Published
2023
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28. Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia

Author

Belchamber, Kylie B. R., primary, Thein, Onn S., additional, Hazeldine, Jon, additional, Grudzinska, Frances S., additional, Faniyi, Aduragbemi A., additional, Hughes, Michael J., additional, Jasper, Alice E., additional, Yip, Kay Por, additional, Crowley, Louise E., additional, Lugg, Sebastian T., additional, Sapey, Elizabeth, additional, Parekh, Dhruv, additional, Thickett, David R., additional, and Scott, Aaron, additional

Published
2022
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29. Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers

Author

Lugg, Sebastian T, primary, Mackay, William R, additional, Faniyi, Aduragbemi A, additional, Faustini, Sian E, additional, Webster, Craig, additional, Duffy, Joanne E, additional, Hewison, Martin, additional, Shields, Adrian M, additional, Parekh, Dhruv, additional, Richter, Alex G, additional, Scott, Aaron, additional, and Thickett, David R, additional

Published
2022
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35. CArdiovaSCulAr outcomes after major abDominal surgEry: study protocol for a multicentre, observational, prospective, international audit of postoperative cardiac complications after major abdominal surgery

Author

Kouli, Omar, Chaudhry, Daoud, Shafi, Shiraz Q., Riad, Aya M., Bhangu, Aneel, Biccard, Bruce, Blanco-Colino, Ruth, Docherty, Annemarie B., El-Boghdadly, Kariem, Glasbey, James C., Harrison, Ewen M., Martin, Janet, McLean, Kenneth A., Mills, Emily C., Moug, Susan J., Mouton, Ronelle, Phull, Mandeep, Pinkney, Thomas, Richards, Toby, Sgrò, Alessandro, Smart, Neil, Thickett, David R., Kamarajah, Sivesh K., Brindl, Niall, Brown, Sam, Cambridge, William A., Gressmann, Kassandra, Gujjuri, Rohan R., Hilder, Amie, Jaffer, Alisha, Jakaityte, Ieva, Kawka, Michal, Matey, Esther, ergo, Aleksandra, Murray, Victoria, Ooi, Setthasorn Z.Y., Pereira, Irène S., Trout, Isobel, Turňa, Adam, Varghese, Chris, and Xu, William

Published
2022
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37. Real-world evaluation of rapid and laboratory-free COVID-19 triage for emergency care: external validation and pilot deployment of artificial intelligence driven screening

Author

Soltan, Andrew A S, primary, Yang, Jenny, additional, Pattanshetty, Ravi, additional, Novak, Alex, additional, Yang, Yang, additional, Rohanian, Omid, additional, Beer, Sally, additional, Soltan, Marina A, additional, Thickett, David R, additional, Fairhead, Rory, additional, Zhu, Tingting, additional, Eyre, David W, additional, Clifton, David A, additional, Watson, Adam, additional, Bhargav, Akshay, additional, Tough, Alex, additional, Rogers, Alice, additional, Shaikh, Ayisha, additional, Valensise, Carolina, additional, Lee, Charlotte, additional, Otasowie, Claire, additional, Metcalfe, David, additional, Agarwal, Ekta, additional, Zareh, Elham, additional, Thangaraj, Evelyn, additional, Pickles, Florence, additional, Kelly, Gabriella, additional, Tadikamalla, Gayatri, additional, Shaw, George, additional, Tong, Heather, additional, Davies, Hettie, additional, Bahra, Jasdeep, additional, Morgan, Jessica, additional, Wilson, Joe, additional, Cutteridge, Joseph, additional, O'Byrne, Katherine, additional, Farache Trajano, Luiza, additional, Oliver, Madeleine, additional, Pikoula, Maria, additional, Mendoza, Maya, additional, Keevil, Melissa, additional, Faisal, Muhammad, additional, Dole, Natasha, additional, Deal, Oscar, additional, Conway-Jones, Rebecca, additional, Sattar, Shajeel, additional, Kundoor, Sneha, additional, Shah, Sumaiyah, additional, and Muthusami, Vani, additional

Published
2022
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38. Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

Author

Fisher, Benjamin A, primary, Veenith, Tonny, additional, Slade, Daniel, additional, Gaskell, Charlotte, additional, Rowland, Matthew, additional, Whitehouse, Tony, additional, Scriven, James, additional, Parekh, Dhruv, additional, Balasubramaniam, Madhu S, additional, Cooke, Graham, additional, Morley, Nick, additional, Gabriel, Zoe, additional, Wise, Matthew P, additional, Porter, Joanna, additional, McShane, Helen, additional, Ho, Ling-Pei, additional, Newsome, Philip N, additional, Rowe, Anna, additional, Sharpe, Rowena, additional, Thickett, David R, additional, Bion, Julian, additional, Gates, Simon, additional, Richards, Duncan, additional, Kearns, Pamela, additional, Williams, Bryan, additional, Turner, Rebecca, additional, Libri, Vincenzo, additional, Mussai, Francis, additional, Middleton, Gary, additional, Bowden, Sarah, additional, Bangash, Mansoor, additional, Gao-Smith, Fang, additional, Patel, Jaimin, additional, Sapey, Elizabeth, additional, Thomas, Mark, additional, Coles, Mark, additional, Watkinson, Peter, additional, Rahman, Naj, additional, Angus, Brian, additional, Mentzer, Alexander J., additional, Novak, Alex, additional, Feldman, Marc, additional, Richter, Alex, additional, Faustini, Sian, additional, Bathurst, Camilla, additional, Van de Wiel, Joseph, additional, Mee, Susie, additional, James, Karen, additional, Rahman, Bushra, additional, Turner, Karen, additional, Hill, Adam, additional, Gordon, Anthony, additional, Yap, Christina, additional, Matthay, Michael, additional, McAuley, Danny, additional, Hall, Andrew, additional, Dark, Paul, additional, and McMichael, Andrew, additional

Published
2022
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42. Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)

Author

Wild, Jim M., Porter, Joanna C., Molyneaux, Philip L., George, Peter M., Stewart, Iain, Allen, Richard James, Aul, Raminder, Baillie, John Kenneth, Barratt, Shaney L., Beirne, Paul, Bianchi, Stephen M., Blaikley, John F., Brooke, Jonathan, Chaudhuri, Nazia, Collier, Guilhem, Denneny, Emma K., Docherty, Annemarie, Fabbri, Laura, Gibbons, Michael A., Gleeson, Fergus V., Gooptu, Bibek, Hall, Ian P., Hanley, Neil A., Heightman, Melissa, Hillman, Toby E., Johnson, Simon R., Jones, Mark G., Khan, Fasihul, Lawson, Rod, Mehta, Puja, Mitchell, Jane A., Poinasamy, Krisnah, Quint, Jennifer K., Rivera-Ortega, Pilar, Semple, Malcolm, Simpson, A. John, Smith, D.J.F., Spears, Mark, Spencer, LIsa G., Stanel, Stefan C., Thickett, David R., Thompson, A.A. Roger, Walsh, Simon L.F., Weatherley, Nicholas D., Weeks, Mark Everard, Wootton, Dan G., Brightling, Chris E., Chambers, Rachel C., Ho, Ling-Pei, Jacob, Joseph, Piper Hanley, Karen, Wain, Louise V., and Jenkins, R. Gisli

Subjects
Pulmonary and Respiratory Medicine, respiratory system, respiratory tract diseases
Abstract

Introduction The COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD).Methods and analysis The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment.Ethics and dissemination All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals.Conclusion This study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.

Published
2021

43. CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults

Author

Veenith, Tonny, primary, Fisher, Benjamin A., additional, Slade, Daniel, additional, Rowe, Anna, additional, Sharpe, Rowena, additional, Thickett, David R., additional, Whitehouse, Tony, additional, Rowland, Matthew, additional, Scriven, James, additional, Parekh, Dhruv, additional, Bowden, Sarah J., additional, Savage, Joshua S., additional, Richards, Duncan, additional, Bion, Julian, additional, Kearns, Pamela, additional, and Gates, Simon, additional

Published
2021
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44. Vitamin D Status: A U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers

Author

Mackay, William R, primary, Lugg, Sebastian T, additional, Faniyi, Aduragbemi A, additional, Faustini, Sian, additional, Webster, Craig, additional, Duffy, Joanne, additional, Hewison, Martin, additional, Shields, Adrian, additional, Richter, Alex A, additional, Parekh, Dhruv, additional, Scott, Aaron, additional, and Thickett, David R, additional

Published
2021
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45. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

Author

Dancer, Rachel C A, Parekh, Dhruv, Lax, Sian, DʼSouza, Vijay, Zheng, Shengxing, Bassford, Chris R, Park, Daniel, Bartis, D G, Mahida, Rahul, Turner, Alice M, Sapey, Elizabeth, Wei, Wenbin, Naidu, Babu, Stewart, Paul M, Fraser, William D, Christopher, Kenneth B, Cooper, Mark S, Gao, Fang, Sansom, David M, Martineau, Adrian R, Perkins, Gavin D, and Thickett, David R

Published
2015
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49. COVID-19 admission risk tools should include multiethnic age structures, multimorbidity and deprivation metrics for air pollution, household overcrowding, housing quality and adult skills

Author

Soltan, Marina A, primary, Varney, Justin, additional, Sutton, Benjamin, additional, Melville, Colin R, additional, Lugg, Sebastian T, additional, Parekh, Dhruv, additional, Carroll, Will, additional, Dosanjh, Davinder P, additional, and Thickett, David R, additional

Published
2021
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