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1. Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

Author

Henrique Andrade Rodrigues da Fonseca, Henrique Tria Bianco, Francisco Antonio Helfenstein Fonseca, Carolina Nunes França, Edna S Costa, Thiago T. de Freitas, Juliana T. Kato, Maria Cristina de Oliveira Izar, and Antônio Martins Figueiredo Neto

Subjects
Blood Glucose, Male, medicine.medical_specialty, Waist, medicine.medical_treatment, Medicine (miscellaneous), Type 2 diabetes, Prediabetic State, Insulin resistance, Diabetes mellitus, Internal medicine, medicine, Humans, Insulin, Biomass, Glycated Hemoglobin, Nutrition and Dietetics, Gastric emptying, business.industry, GLICEMIA, Musa, Starch, Fasting, Middle Aged, medicine.disease, Diet, Endocrinology, Diabetes Mellitus, Type 2, Metabolic control analysis, Body Composition, Lean body mass, Female, Insulin Resistance, business
Abstract

Diabetes mellitus is a global epidemic, characterised as a heterogeneous group of metabolic disorders associated with high risk of CVD. Green banana biomass, which is composed of resistant starches (RS) and cannot be hydrolysed by amylases, delays gastric emptying and modulates insulin sensitivity, thus contributing to improve metabolic disorders. The aim of the present study was to investigate the effects of consumption of RS from green banana biomass on body composition, fasting plasma glucose, glycated Hb (HbA1c) and homeostasis model assessment of insulin resistance in subjects with pre-diabetes or type 2 diabetes on top of treatment. Middle-aged subjects (n113) of both sexes with pre-diabetes (HbA1c: 5·7–6·4 %) or diabetes (HbA1c ≥ 6·5 %) were randomised to receive nutritional support plus green banana biomass (40 g) (RS: approximately 4·5 g, G1,n62) or diet alone (G2,n51) for 24 weeks. Body composition, biochemical analyses and dietary intake were evaluated at the beginning and end of the study. In the experimental group (G1), consumption of RS was associated with reduction in HbA1c (P= 0·0001), fasting glucose (P= 0·021), diastolic blood pressure (P= 0·010), body weight (P= 0·002), BMI (P= 0·006), waist and hip circumferences (P< 0·01), fat mass percentage (P= 0·001) and increase in lean mass percentage (P= 0·011). In controls (G2), reductions were observed in waist and hip circumferences (P< 0·01), HbA1c (P= 0·002) and high-density lipoprotein-cholesterol (P= 0·020). In pre-diabetes or diabetes, non-significant differences were observed in the percentage reduction in HbA1c and fasting glucose in exploratory analyses. Our results indicate that the consumption of bioactive starches is a good dietary strategy to improve metabolic control and body composition.

Published
2019
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2. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial

Author

Sende O. de Jesus, Fernanda C. Amparo, Marta M. David, Sara Bobadra, Lilian P.S. Costa, Keyla L.A.L. Deucher, Juliana D Oliveira, Izabele Vian, Janaina Maiana Abreu Barbosa, Karina C.S. Missias, Alexandre Biasi Cavalcanti, Luisa P. Silva, Lannay Ferreira da Silva, Andrea P. Galante, Adriana Barros Luna, Jâniffer R. Beiersdorf, Ângela Cristine Bersch-Ferreira, Diana S. Russo, Marilia C.S. Lucas, Maria Bárbara Galdino Silva, Monique T. de Jesus, Rosângela Maria Lopes de Sousa, Délcio G.S. Junior, Raquel Milani El Kik, Sandramara Sasso, Celme B.P. de Araújo, Nathalia P. Bachettini, Maria A. Moraes, Neuma M.F.S. Leda, Cristine E. Nunes, Bruna G. Machado, Rafael M. Soares, Salvador S. Ramos, Bianca A.S. de Oliveira, Rosa Bosquetti, Cristiano P. dos Santos, Franciane Silvana Formentini, Adriana O.L. Veríssimo, Rosielle Batista Ferreira, Clenise F. Dantas, Valdiana B. Vasconcelos, Maria Renata Aragão dos Santos, Ana Paula O. de Queirós, Edite M.V.M. C. de Araújo, Luciana Pereira Pinto Dias, Francisca Eugenia Zaina Nagano, Sandra Mary Lima Vasconcelos, Elaine de Fatima Adorne, Gabriela S. Shirmann, Celma M. Martins, Aldair S. Guterres, Ana Paula Silva Caldas, Marina Berbigier, Alessandra C. Caiado, Fernanda L. Chiesa, Laís N.P. Navarro, Vera Elizabeth Closs, Raira Pagano, Cristina H. Matos, Juliane A. Rodrigues, Luciana B. Gonçalves, Raphaela Costa Ferreira, Rosana P. Costa, Isa G. Rodrigues, Emílio Hideyuki Moriguchi, Rebecca O. Maquiné, Ana P.P.F. Carvalho, Daniela O. Peçanha, Alessandra Doumid Borges Pretto, Michelle R. Santos, Mirena Boklis, Celia R. Bittencourt, Eduardo P. Trescastro, Mariana E.P. Lima, Bruna L.P. Ribas, Adriana F. Teixeira, Marina T. Asoo, Maria I.S. Taboada, Otavio Berwanger, Karen B. Ruschel, Suzi H.A. de Araujo, Nilma F. Silva, Rodrigo Necchi, Camile S. Teixeira, Vanessa C.F.O. Fagundes, Glauber B. da Silva, Carine S.A. Ribeiro, Francisco A. Costa, Sônia L. Pinto, Helen Hermana Miranda Hermsdorff, Suzana A. da Silva, Bárbara Rafaela Santos da Rocha, Rosileide S. Torres, Cíntia L. Ambrozio, Renata Torres Abib Bertacco, Rosângela C.A. Cantanhede, Annie S.B. Moreira, Camila Dourado, Aline Marcadenti, Milena P. Rodrigues, Renata A. da Silva, Daniele M.O. Carlos, Cláudia Porto Sabino Pinho, Rita C.L. Duarte, Lilian Vivian, Eliane S. Dutra, Neyla E. Silva, Luciano M. Backes, Lívia M.A.J. Silva, Letícia S. Sabino, Júlia D. Lopes, Alexsandro Ferreira dos Santos, Lúcia H.A. Gratão, Paulo Victor Gomes Modanese, Cristina T. Telles, Juliana L. Pereira, Luciana V.S. Alves, Tainah S. Souza, Lúcia Rota Borges, Maria Cristina de Oliveira Izar, Priscila Moreira, Simone Raimondi de Souza, Priscila A. Rodrigues, Jorge L. Boemo, Deborah Marotto, Eduardo Gehling Bertoldi, Priccila Zuchinali, Jéssica Schiavini, Susi B. e Lima, Claiza Barretta, Jacqueline T. da Silva, Alexandre Gastaud, Daniela Rampazzo, Vera M.S. Bortonili, Laís B. da Costa, Luciana C. Holzbach, Sabrina A. Vieira, Maria E.M. Ramos, Waldemar de Carli, Magali C.C. Kumbier, Tamirys D. Sangali, Renato Hideo Nakagawa Santos, Elisa M. Santos, Roberta Mânica Cardoso, Simone M. Fischer, Marina K. Ito, Andreza M. Penafort, Naoel H. Feres, Bruno R.B. de Ataíde, Mihaela Onofrei, José Albuquerque de Figueiredo Neto, Camila R. Honório, Enilda de Sousa Lara, Catharina C.J. Paiva, Marina Shumacher, Gabriela C. Souza, Rafael L. Rech, Viviane Aparecida Rodrigues Sant'Anna, Antônio Carlos Sobral Sousa, Laura M. da Costa, André Eduardo da Silva Júnior, Luíza M. Garlini, Cintia G.N.C. Cordeiro, Rose M. Uehara, Karina G. dos Santos, Josilene Maria Ferreira Pinheiro, Natalia de Morais Cunha, Camila Ragne Torreglosa, Luis G.S. Mota, Valéria A. Machado, Geysa Maria Nogueira Farias, Auriene L. Medeiros, Amanda G.L. Coura, Kellen C. Silva, Karine Maria Moreira Almeida, Lívia A. Pellegrini, Luana R.M. Lima, Guilherme C.M. Bragança, Joise M. Teixeira, Aline Longo, Vanessa Bertoni, Cristiane Kovacs, Fernanda Vighi Dobke, Paula Souza, Alessandra da Silva, Elza C.B. Barbosa, Clarice M. Specht, Carlos D. Magnoni, Alechandra S. Napparo, Isadora Bianco Cardoso, Mônica L.P. de los Santos, Camila V.S. Souza, Jaqueline S.O. Vieira, Viviane O.G. Nascimento, Luisa F. Reis, Andrea F.R. Cardoso, Jadson M. Morais, Helen M.S. Carvalho, Ana L. Barreto, Lais S. de Paula, Aline S. Monteiro, Josiele Kesties, Ana C.L. Andrade, Juliana T. Kato, Bernardete Weber, Tatiana M.X. de Meneses, Priscila M. Pinho, Thiago T. de Freitas, Joyce Salamoni, Moacyr M. Palmeira, Malaine M.A. Machado, Bianca M. Fracasso, Viviane Sahade, Givaldo A. Araújo, Fernando G. Zampieri, Matheus Brum Felício, Soraia Poloni, Neide M. Bruscato, Caroline Frehner, Josefina Bressan, Andreza Santos Almeida, Socorro N.A.A. Barbosa, Helyde Albuquerque Marinho, Patrícia R.T. Martins, Maiara Cantarelli, and Monica Damiani

Subjects
Male, Nutrition Education, Body Mass, National Health Programs, 030204 cardiovascular system & hematology, Vegetable, Procedures, Prescription, law.invention, 0302 clinical medicine, Cerebrovascular Accident, Randomized controlled trial, law, Risk Factors, Cardiovascular Disease, Cause of Death, Clinical endpoint, Whole Grain, Secondary Prevention, 030212 general & internal medicine, Myocardial infarction, All Cause Mortality, Amputation, Program Development, Stroke, Sex Difference, Alcohol Consumption, Incidence (epidemiology), Incidence, Unstable Angina Pectoris, Middle Aged, Clinical Trial, Hospitalization, Multicenter Study, Survival Rate, Practice Guideline, Cardiovascular Diseases, Randomized Controlled Trial, Priority Journal, Female, Public Health, Cardiology and Cardiovascular Medicine, Brazil, Human, Adult, medicine.medical_specialty, Major Clinical Study, Nutritional Status, Follow Up, 03 medical and health sciences, Age, Cause Of Death, Multicenter trial, Internal medicine, medicine, Humans, Controlled Study, Nutritional Assessment, Study Design, Unstable angina, business.industry, Brasil, Risk Factor, medicine.disease, Heart Infarction, Heart Arrest, Diet, Blood pressure, Nutrition Assessment, Fruit, Family Income, business, Cardiovascular Risk, Diet Therapy, Nutritional Counseling, Total Quality Management
Abstract

Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P

Published
2019

3. Beneficial effects of green banana biomass consumption in patients with pre-diabetes and diabetes: A randomized controlled trial

Author

Henrique Tria Bianco, Edna S Costa, Maria Cristina de Oliveira Izar, Henrique Andrade Rodrigues da Fonseca, Juliana Tieko Kato, Thiago T. de Freitas, Antônio Martins Figueiredo Neto, Carolina Nunes França, and Francisco Antonio Helfenstein Fonseca

Subjects
0301 basic medicine, Consumption (economics), 030109 nutrition & dietetics, business.industry, Biomass, medicine.disease, law.invention, Toxicology, 03 medical and health sciences, Randomized controlled trial, law, Pre diabetes, Diabetes mellitus, Medicine, In patient, Cardiology and Cardiovascular Medicine, business, Beneficial effects
Published
2018
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4. Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring.

Author

de Freitas T, Zapaterini JR, Moreira CM, de Aquino AM, Alonso-Costa LG, Bidinotto LT, Kass L, Flaws JA, Scarano WR, and Barbisan LF

Subjects
Animal Feed, Animals, Dose-Response Relationship, Drug, Environmental Pollutants administration & dosage, Environmental Pollutants classification, Female, Gene Expression Regulation drug effects, Ki-67 Antigen genetics, Ki-67 Antigen metabolism, Methylnitrosourea toxicity, Phthalic Acids administration & dosage, Phthalic Acids classification, Pregnancy, Rats, Rats, Sprague-Dawley, Receptors, Progesterone genetics, Receptors, Progesterone metabolism, Carcinogenesis chemically induced, Environmental Pollutants toxicity, Mammary Neoplasms, Animal chemically induced, Phthalic Acids toxicity, Prenatal Exposure Delayed Effects
Abstract

Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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5. Anacardic acid from brazilian cashew nut trees reduces dentine erosion.

Author

Silveira C, Oliveira F, Dos Santos ML, de Freitas T, Imparato JC, and Magalhães AC

Subjects
Anacardic Acids pharmacology, Animals, Antioxidants therapeutic use, Cariostatic Agents therapeutic use, Catechin analogs & derivatives, Catechin therapeutic use, Cattle, Dentin ultrastructure, Matrix Metalloproteinase 2 drug effects, Matrix Metalloproteinase Inhibitors pharmacology, Microscopy, Electron, Scanning, Plant Extracts pharmacology, Sodium Fluoride therapeutic use, Tooth Demineralization prevention & control, Tooth Remineralization, Tooth Root drug effects, Anacardic Acids therapeutic use, Anacardium, Dentin drug effects, Nuts, Phytotherapy methods, Plant Extracts therapeutic use, Tooth Erosion prevention & control
Abstract

The aim of this study was to analyze the effect of solutions containing saturated anacardic acid (AA) on dentine erosion in vitro. AA was chemically isolated from natural cashew nutshell liquid obtained by continuous extraction in a Soxhlet extractor and was fully saturated by catalytic hydrogenation. Matrix metalloproteinase 2 (MMP-2) activity, when exposed to buffers containing 100 µmol/l AA, was analyzed using zymography. Bovine root samples were subjected to erosive demineralization (Sprite Zero™, 4 × 90 s/day) and remineralization with artificial saliva between the erosive cycles for 5 days. The samples were treated as follows, after the first and the last acid exposure (1 min; n = 12/group): (1) 100 µmol/l epigallocatechin-3-gallate (EGCG) (positive control); (2) 0.05% NaF; (3) 100 µmol/l saturated AA; (4) saturated AA and EGCG; (5) saturated AA, EGCG and NaF; (6) untreated (negative control). Dentine erosion was measured using a contact profilometer. Two dentine samples from each group were analyzed using scanning electron microscopy. Saturated AA reduced the activity of MMP-2. ANOVA and Tukey's test revealed that all treatments significantly reduced dentine loss compared to the negative control (6.03 ± 0.98 µm). Solutions containing saturated AA (1.97 ± 1.02 µm) showed the greatest reduction in dentine erosion compared to the NaF (3.93 ± 1.54 µm) and EGCG (3.79 ± 0.83 µm) solutions. Therefore, it may be concluded that AA significantly reduces dentine erosion in vitro, possibly by acting as an MMP-2 inhibitor.

Published
2014
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