Search

Your search keyword '"Thi Chi Mai Tran"' showing total 4 results
Start Over Author "Thi Chi Mai Tran"
4 results on '"Thi Chi Mai Tran"'

1. The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures

Author

Tze Ping Loh, Brian R. Cooke, Thi Chi Mai Tran, Corey Markus, Rosita Zakaria, Chung Shun Ho, Elvar Theodorsson, and Ronda F. Greaves

Subjects
Emerging technology(ies), Method verification, Method validation (3–6), Medicine (General), R5-920, Chemistry, QD1-999
Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript.The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the LEAP checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners.

Published
2024
Full Text
View/download PDF

2. The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures

Author

Loh, Tze Ping, Cooke, Brian R., Thi Chi Mai Tran, Markus, Corey, Zakaria, Rosita, Ho, Chung Shun, Theodorsson, Elvar, Greaves, Ronda F., Loh, Tze Ping, Cooke, Brian R., Thi Chi Mai Tran, Markus, Corey, Zakaria, Rosita, Ho, Chung Shun, Theodorsson, Elvar, and Greaves, Ronda F.

Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the Laboratory Evaluation and Analytical Performance Characteristics (LEAP) checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners.

Published
2023
Full Text
View/download PDF

3. Validation of steroid ratios for random urine by mass spectrometry to detect 5α-reductase deficiency in Vietnamese children

Author

Thi Chi Mai, Tran, Thi Ngoc Anh, Tran, Hoang Bich Nga, Le, Viet Hoa, Nguyen, Minh Dien, Tran, Chi Dung, Vu, and Ronda F, Greaves

Subjects
Male, Hypospadias, Steroid Metabolism, Inborn Errors, Disorder of Sex Development, 46,XY, Biochemistry (medical), Clinical Biochemistry, Infant, Membrane Proteins, General Medicine, Gas Chromatography-Mass Spectrometry, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Asian People, Vietnam, Humans, Steroids, Child, Oxidoreductases, Tetrahydrocortisol
Abstract

Objectives The 5α-reductase-type-2 deficiency (5ARD2) is a rare autosomal recessive 46,XY disorder of sex development caused by the mutated 5α-reductase type 2 (SRD5A2) gene. In this disease, defective conversion of testosterone to dihydrotestosterone leads to variable presentations of male ambiguous genitalia during fetal development. We aimed to examine characteristics of patients presenting with 5ARD2 over a 4 year period. Methods Random urine samples of control and patients with suspected 5ARD2 were collected and urine steroidomic metabolites were measured by Gas chromatography-mass spectrometry (GC-MS) in the period from 2017 to 2021 at National Children’s Hospital, Hanoi Vietnam. 5α- to 5β-reduced steroid metabolite ratio, 5a-tetrahydrocortisol to tetrahydrocortisol (5α-THF/THF), was reviewed by receive operator characteristics (ROC) curve analysis. Molecular testing was offered to 25 patients who were diagnosed with 5ARD2 by GC-MS urinary steroid analysis. Results Urine steroidomic profiling was conducted for 104 male controls and 25 patients between the ages of 6 months and 13 years old. Twelve of the twenty-five 5ARD2 patients agreed to undertake genetic analysis, and two mutations of the SRD5A2 gene were detected in each patient, confirming the diagnosis. All patients showed a characteristically low ratio of 5α-THF/THF. There was no overlap of 5α-THF/THF ratio values between control and 5ARD2 groups. The ROC of 5α-THF/THF ratio at 0.19 showed 100% sensitivity and 100% specificity for boys between 6 months and 13 years of age. Conclusions Analysis of the urine steroid metabolome by GC-MS can be used to assist in the diagnosis of 5ARD2. We recommend consideration of random urine steroid analysis as a first-line test in the diagnosis of 5ARD2.

Published
2022

4. The LEAP checklist for Laboratory Evaluation and Analytical Performance Characteristics reporting of clinical measurement procedures.

Author

Tze Ping Loh, Cooke, Brian R., Thi Chi Mai Tran, Markus, Corey, Zakaria, Rosita, Chung Shun Ho, Theodorsson, Elvar, and Greaves, Ronda F.

Subjects
PATHOLOGICAL laboratories, CHEMICAL laboratories, CLINICAL pathology, CLINICAL chemistry, INTERNATIONAL organization, EVALUATION methodology
Abstract

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the LEAP checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results