1. Structural Characterization of Mono and Dihydroxylated Umbelliferone Derivatives
- Author
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Beñat Artetxe, José Luis Vilas-Vilela, Juan M. Gutiérrez-Zorrilla, Ángel Marcos-Fernández, Rodrigo Navarro, José Manuel Laza, Estibaliz Ruiz-Bilbao, Rubén Seoane-Rivero, José María Cuevas, Eusko Jaurlaritza, Ministerio de Ciencia, Innovación y Universidades (España), and Ministerio de Economía y Competitividad (España)
- Subjects
Ultraviolet Rays ,Proton Magnetic Resonance Spectroscopy ,photophysical ,Phytochemicals ,Pharmaceutical Science ,Hydroxyl-modifiedcoumarin ,Umbelliferone ,coumarin ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,Differential scanning calorimetry ,X-Ray Diffraction ,lcsh:Organic chemistry ,Coumarins ,Drug Discovery ,Hydroxides ,Humans ,Molecule ,Umbelliferones ,Physical and Theoretical Chemistry ,Thermal analysis ,Spectroscopy ,chemistry.chemical_classification ,Calorimetry, Differential Scanning ,Molecular Structure ,Plant Extracts ,Chemistry ,hydroxyl-modified coumarin ,thermal and structural characterization ,Organic Chemistry ,Polymer ,Thermal andstructural characterization ,Coumarin ,Combinatorial chemistry ,Chemistry (miscellaneous) ,Solvents ,Proton NMR ,Molecular Medicine ,Crystallization ,Apiaceae - Abstract
Coumarin derivatives are a class of compounds with a pronounced wide range of applications, especially in biological activities, in the medicine, pharmacology, cosmetics, coatings and food industry. Their potential applications are highly dependent on the nature of the substituents attached to their nucleus. These substituents modulate their photochemical and photophysical properties, as well as their interactions in their crystalline form, which largely determines the final field of application. Therefore, in this work a series of mono and dihydroxylated coumarin derivatives with different chemical substituents were synthesized and characterized by UV-Visible spectroscopy, thermal analysis (differential scanning calorimetry (DSC) and TGA), 1H NMR and X-Ray Diffraction to identify limitations and possibilities as a function of the molecular structure for expanding their applications in polymer science., This research was funded by the Basque Government within the framework ELKARTEK through the research project KK-2018/00108 and KK-2019/00077. This work was also funded by the Ministry of Economy and Competitiveness—Spain (MINECO) through the research Projects RTC-2016-4887-4 and RTI2018-096636-J-100 within the framework of the National Programme for Research Aimed at the Challenges of Society
- Published
- 2020