253 results on '"Theodorou, I."'
Search Results
2. Assessing good environmental status through mesozooplankton biodiversity: a step forward
- Author
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Theodorou, I, primary, Zervoudaki, S, additional, Varkitzi, I, additional, and Tsirtsis, G, additional
- Published
- 2022
- Full Text
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3. Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients
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Evangelou, D, primary, Bechlioulis, A, additional, Tzeltzes, G, additional, Lakkas, L, additional, Theodorou, I, additional, Kalaitzidis, R, additional, Dounousi, E, additional, Michalis, L K, additional, and Naka, K K, additional
- Published
- 2022
- Full Text
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4. Impact of KIR/HLA genetic combinations on double umbilical cord blood transplantation outcomes. Results of a French multicentric retrospective study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and the Société Francophone d’Histocompatibilité et d’Immunogénétique (SFHI)
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Rettman, P, Malard, F, Legrand, N, Avinens, O, Eliaou, J-F, Picard, C, Dormoy, A, Lafarge, X, de Matteis, M, Kennel, A, Loiseau, P, Devys, A, Boudifa, A, Absi, L, Fort, M, Masson, D, Quainon, F, Theodorou, I, Batho, A, Parissiadis, A, Delbos, F, Drouet, M, Senitzer, D, Marry, E, Raus, N, Yakoub-Agha, I, Cesbron, A, Retière, C, and Gagne, K
- Published
- 2016
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5. Successful response in a case of severe pustular psoriasis after interleukin‐1β inhibition
- Author
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Skendros, P., Papagoras, C., Lefaki, I., Giatromanolaki, A., Kotsianidis, I., Speletas, M., Bocly, V., Theodorou, I., Dalla, V., and Ritis, K.
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- 2017
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6. Assessing good environmental status through mesozooplankton biodiversity: a step forward.
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Theodorou, I, Zervoudaki, S, Varkitzi, I, and Tsirtsis, G
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MARINE biodiversity , *WATER quality , *FISHER discriminant analysis , *ENVIRONMENTAL indicators , *BIODIVERSITY , *WATER sampling - Abstract
We developed a zooplankton-based water-quality evaluating method using indices of alpha diversity. Two key objectives were set: (i) the comparison of two—different quality—samples from different areas, and the verification of their differentiation, based on mesozooplankton biodiversity indices; and (ii) the development of a methodology, which was able to assess the quality of new marine water samples. Our analysis was based on a 24-year-long in situ dataset (1987–2010) of 139 samples in which 86 mesozooplankton taxa were identified. High-diversity and high evenness values were reported in the case of the "good" status sample, while low diversity, low evenness and high dominance values occurred at the lower quality one. A linear discriminant analysis (LDA) was conducted that discriminated the tested samples at 100%. This LDA was then used to evaluate samples of unknown quality. Finally, 90% of them were classified with a probability of correct classification (posterior probability) >95%. The present study proves that mesozooplankton diversity indices can discriminate different levels of anthropogenic impacts. In this sense, it can be used as a reliable indicator for environmental assessment in the pelagic habitats of the Mediterranean Sea. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study
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Gagne, K, Loiseau, P, Dubois, V, Dufossé, F, Perrier, P, Dormoy, A, Jollet, I, Renac, V, Masson, D, Picard, C, Lafarge, X, Hanau, D, Quainon, F, Delbos, F, Coeffic, B, Absi, Léna, Eliaou, J-F, Moalic, V, Fort, M, de Matteis, M, Theodorou, I, Hau, F, Batho, A, Pedron, B, Caillat-Zucman, S, Marry, E, Raus, N, Yakoub-Agha, I, and Cesbron, A
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- 2015
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8. Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection
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GISHEAL Consortium, Guergnon, J., Dalmasso, C., Broet, P., Meyer, L., Westrop, S. J., Imami, N., Vicenzi, E., Morsica, G., Tinelli, M., Poma, B. Zanone, Goujard, C., Potard, V., Gotch, F. M., Casoli, C., Cossarizza, A., Macciardi, F., Debré, P., Delfraissy, J. F., Galli, M., Autran, B., Costagliola, D., Poli, G., Theodorou, I., and Riva, A.
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- 2012
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9. Classical and myocardial deformation echocardiographic indices in chronic kidney disease patients; effects of aging and comparison to healthy controls
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Lakkas, L, primary, Naka, KK, additional, Bechlioulis, A, additional, Girdis, I, additional, Duni, A, additional, Theodorou, I, additional, Koutlas, V, additional, Moustakli, M, additional, Katsouras, CS, additional, Dounousi, E, additional, and Michalis, LK, additional
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- 2022
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10. P16-45. High avidity CD4+ T cell response directed to an immunodominant Gag epitope in HIV controllers: an ANRS EP36 study
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Thèze J, Delfraissy J, Kwok WK, Theodorou I, Lemaître F, Boufassa F, Lambotte O, Jeannin P, Perez-Patrigeon S, Vingert B, and Chakrabarti LA
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2009
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11. Is long-term virological response related to CCR5 Δ32 deletion in HIV-1-infected patients started on highly active antiretroviral therapy?
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Laurichesse, J-J, Taieb, A, Capoulade-Metay, C, Katlama, C, Villes, V, Drobacheff-Thiebaud, M-C, Raffi, F, Chêne, G, Theodorou, I, and Leport, C
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- 2010
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12. Label-free TOF-SIMS imaging of sulfur producing enzymes inside microglia cells following exposure to silver nanowires
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Leo, BF, Fearn, S, Gonzalez-Carter, D, Theodorou, I, Ruenraroengsak, P, Goode, A, Mcphail, D, Dexter, DT, Shaffer, MSP, Chung, KF, Porter, AE, and Ryan, MP
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Chemistry ,Science & Technology ,TOF-SIMS ,TISSUE ,Physical Sciences ,Chemistry, Analytical ,0399 Other Chemical Sciences ,0904 Chemical Engineering ,0301 Analytical Chemistry ,Analytical Chemistry - Abstract
There are no methods sensitive enough to detect enzymes within cells, without the use of analyte labelling. Here we show that it is possible to detect protein ion signals of three different H2S-synthesizing enzymes inside microglia after pre-treatment with silver nanowires (AgNW) using time of flight-secondary ion mass spectrometry (TOF-SIMS). Protein fragment ions, including the fragment of amino acid (C4H8N+ - 70 amu), fragments of the sulfur producing cystathionine-containing enzymes and the Ag+ ion signal could be detected without the use of any labels; the cells were mapped using the C4H8N+ amino acid fragment. Scanning electron microscopy imaging and energy dispersive x-ray chemical analysis showed that the AgNWs were inside the same cells imaged by TOF-SIMS and transformed chemically into crystalline Ag2S within cells in which the sulfur producing proteins were detected. The presence of these sulfur producing cystathionine-containing enzymes within the cells was confirmed by Western Blots and confocal microscopy images of fluorescently labelled antibodies against the sulfur producing enzymes. Label-free ToF-SIMS is very promising for the label-free identification of H2S-contributing enzymes and their cellular localization in biological systems. The technique could in future be used to identify which of these enzymes are most contributory.
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- 2019
13. Polymorphisms in CCR5 chemokine receptor gene in Japan
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Liu, H., Nakayama, E. E., Theodorou, I., Nagai, Y., Likanonsakul, S., Wasi, C., Debre, P., Iwamoto, A., and Shioda, T.
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- 2007
14. Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 Δ32 deletion
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Laurichesse, J J, Persoz, A, Theodorou, I, Rouzioux, C, Delfraissy, J F, and Meyer, L
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- 2007
15. Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection
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McIlroy, D., Meyer, L., Dudoit, Y., Samri, A., Delfraissy, J.-F., Autran, B., Debré, P., and Theodorou, I.
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- 2006
16. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. I., Torbergsen, T., Mellgren, S. I., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Boller, F., Bonavita, V., Engelhardt, A., Lörler, H., Robeck, S., Kluglein, C., Comi, G., Avoledo, V., Locatelli, T., Leocani, L., Galardi, G., Magnani, G., Medaglini, S., Chkhikvishvili, T. S., Zangaladze, A., Bratoeva, M., Kovachev, P., Chavdarov, D., Artemis, N., Karacostas, D., Milonas, I., Arpa, J., Lopez-Pajares, R., Cruz-Matinez, A., Sarria, J., Palomo, F., Alonso, M., Rodriguez-Al-barino, A., Lacasa, T., Nos, J., Barreiro, P., Martinez, A. Cruz, Villoslada, C., Alons, M., Taghavy, A., Hamer, H., Kratzer, A., Dethy, S., Pauwels, T., Monclus, M., Luxen, A., Goldman, S., Ziegler, M., Crambes, O., Ragueneau, I., Arnaud, F., Zappia, M., Montesanti, R., Colao, R., Palmieri, A., Branca, D., Nicoletti, G., Rizzo, M., Parlato, G., Quattrone, A., Vanacore, N., Zuchegna, P., Bonifati, V., Meco, G., Scholz, J., Friedrich, H. -J., Rohl, A., Ulm, G., Vieregge, P., Savettieri, G., Rocca, W. A., Meneghini, F., Grigoletto, F., Morgante, L., Reggio, A., Salemi, G., Di Pierri, R., OzckmekÇi, S., Ertan, S., Yeni, N., Apaydin, H., Erkol, G., Kiziltan, G., Denktas, F., Ranoux, D., de Recondo, J., Ostergaard, L., Werdelin, L., Odin, P., Lindvall, O., Dupont, E., Christensen, P. B., Boisen, E., Jensen, N. B., Schmiegelow, M., Ingwersen, S. H., Matias-Guiu, J., Canet, T., Falip, R., Martin, R., Galiano, L., Voloshin, M. Y., Burchinskaya, L. F., Cabrera-Valdivia, F., Jimenez-Jimenez, F. J., Molina, J. A., Fernandez-Calle, P., Vazquez, A., Canizares-Liebana, F., Larumbe-Lobalde, S., Ayuso-Peralta, L., Rabasa, M., Codoceo, R., Arrieta, F. J., Aguilar, M. V., Jorge-Santamaria, A., Martinez-Para, M. C., Alarcon, J., Mateo, D., Gimenez-Roldan, S., Gencheva, E., Tzonev, T. z., Georgiev, G., Petkova, P., Gasparini, M., Vanacore, N., Meco, N. G., de la Sierra, G., Aguado, F., Revilla, M., Varela, L., Rico, H., Feve, A., N'Guyen, J. P., Bathien, N., Fenelon, G., Veroust, J., Cesaro, P., Egersbach, G., Hattig, H., Schelosky, L., Wissel, J., Poewe, W., Durif, F., Albuisson, E., Debilly, B., Tournilhac, M., Magnani, C., Mocellini, C., Soffietti, R., Schiffer, D., Cardozo, A., Cruz-Sanchez, F. F., Falip, L., Potagas, G., Ziegler, M., Rondot, P., Bonifati, V., Fabrizio, E., Meco, G., Bostantjopoulou, S., Katsarou, Z., Kyriazis, G., Baas, H., Demisch, L., Esser, A., Zoeller, F., Burklin, F., Harder, S., Fischer, P. A., Arcusa, M. J., Hermandez, S., Claramonte, F. J., Pascual, A. Pascual- Leone, Alonso, M. D., Catata, M. D., Alessandri, A., Giustini, P., Dufour, A., Ciusani, E., Nespolo, A., Roelcke U., Radu E. W., von Ammon K., Maguire R. P., Leenders K. L., Radionova, M., Chavdarov, D., Bratoeva, M., Tzekov, Ch., Pietrangeli, A., Bove, L., Pace, A., Falqui, L., Jandolo, B., Potemkowski, A., Muller B., Reinhard I., Krone A., Warmuth M., Brocker E. M., Krauseneck P., Meyding-Lamadé, U., Krieger, D., Sartor, K., Hacke, W., Maugard-Louboutin, C., Fayet, G., Sagan, C., Martin, S., Ménégalli, D., Lajat, Y., Resche, F., Koriech, O. M., Al Moutaery, K., Yaqub, B., Jochens, R., Wolters, A., Venz, S., Cordes, M., Hecht, B. K., Chatel, M., Gaudray, P., Turc-Carel, C., Gioanni, J., Ayraud, N., Hecht, F., Rumbach, L., Racadot, E., Bataillard, M., Billot, M., Pariset, J., Wijdenes, J., Montalban, Rio J., Tintoré, M., Galan, I., Acarin, N., Rapaport, S., Huberman, M., Shechtcr, D., Karabudak, R., Kilinc, M., Boyacigil, S., Cila, A., Polo, J. M., Setien, S., Sanchez, R., Figols, J., Zubimendi, A., Nadareishvili, Z. G., Massot, R., Marés, R., Gallecho, F., Richart, C., Hernandez, M. A., Garcia, M. R., Lorenzo, J. N., Leon, C., Muros, M., Togores, J., Kutluk, K., Damlacik, G. A., Tekinsoy, B., Obuz, O., Baklan, B., Idiman, E., Genc, K., Zielasek, J., Schmidt, B., Liew, F. Y., Gulay, Z., Yulug, N., Wong, K. S., Wong, T. W., Yu, T. S., Kay, R., Poupon, R., Giral, P., Roberti, C., Zanette, E. M., Chiarotti, F., Brusa, L., Cerbo, R., Prusinski, A., Pondal, M., Canton, R., Dominigo, Erodriguez J., Pereira Monteino J. M., Pereira Monteino X., Pardo, J., Carroacedo, A., Barros, F., Lema, M., Castillo, J., Melchor, A., Montiel, I., Guiu, J. Matias, Kloss, T. M., Keidel, M., Jacob, M., Idiman, F., Idman, E., Ozturk, V., Metin, E., Yilmaz, M., Gerard, J. M., Bouton, R., Decamps, D., Herbaut, A. G., Delecluse, F., Cavenaile, M., Divano, L., Chazot, G., Boureau, F., Emile, J., Bertin, L., d'Allens, H., Ferro, J. M., Costa, I., Carletto, F., Catarci, T., Padovani, A., Iandolo, B., Bartoli, M., Bonamini, M., Pulcinelli, F., Pignatelli, P., Russo, M., Gazzaniga, P. P., Barros, J., Pinheiro, J., Correia, A. P., Monteiro, J. M. Pereira, Alvarez-Cermeno, J. C., Avello, G., Sastre, J. L., Vecino, A., Cesar, J. M., Leone, M., Stankov, B., D'Amico, D., Maltempo, C., Moschian, F., Fraschini, F., Bussone, G., Molto, J. 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A., Grazzi, L., Ediboglu, N., Bilgin, H., Ertas, S., Goument, J. -P., Basset, C., Campos, Y., Garcia-Silva, T., Cabello, A., Bussaglia, E., Tizzano, E., Colomer, J., Gimbergues, P., Campagne, D., Bommelaer, C., Delaguillaume, B., Ramtami, H., Ait-Kaci-Ahmed, M., Pascual L. F., Fernandez T., Hortells M., Sanz C., Morales F., Lauritzen, L., Picard, F., Sellal, F., Collard, M., Avramidis, T., Alexiou, E., Anastopoulos, T., Frongillo, D., Delfino, F. A., Cannata, M., Calo, L., Vichi, R., Antonini, G., Fragola, V., Cannata, D., Salas, M., Ruiz, C., Angelard, B., Lacau, J., Guily, St., Sendtner, M., Goadsby, Peter J., Quin, N. P., Gadian, D. G., Roland, P. E., Seitz, Rudiger J., Frackowiak, Richard S. J., Becker, G., Krone, A., Schmidt, K., Hofmann, E., Bogdahn, U., Rosenfeld, M. R., Meneses, P., Kaplitt, M. G., Dalmau, J., Posner, J., Cordon-Cardon, C., Hoang-Xuan, K., Vega, F., Nishisho, I., Moisan, J. P., Theillet, C., Delattre, O., Zhu, Jiahong, Walther, W., Posner, J. B., Roelcke, U., von Ammon, K., Pellikka, R., Lucking, C. H., Walon, C., Boucquey, D., -Van Rijckevorsel, K. Harmant, Lannoy, N., Verellen-Dunoulin, Ch., Liszka, U., Cavaletti, G., Casati, B., Kolig, C., Bogliun, G., Marzorati, L., Johannsen, L., Chio, A., Ruda, R., Vigliani, M. C., Sciolla, R., Seliak, D., Hoang-Xuang, K., Villanueva, J. A., Montalban, X., Arboix, A., Colosimo, C., Albanese, A., Hughes, A. J., de Bruin, V., Lees, A. J., Kowalski, J. W., Banfi, S., Santoro, L., Perretti, A., Castaldo, I., Barbieri, F., Campanella, G., Bhatia, K. P., Mardsen, C. D., de Bruin, V. S., Machedo, C., Ceballos-Baumann, D., Marsden, C. D., Brooks, D. B. J., Wennlng, G. K., Quinn, N., McDonald, W. l., Warner, T. T., Bain, P. C., Davis, M. B., Conway, D., Shaunak, S., O'Sullivan, E., Crawford, T., Lawden, M., Blunt, S., Rapoport, A., Sarova-Pinchas, I., de Beyl, D. Zegers, Mavroudakis, N., Blanc, S., Godinot, C., Lenoir, G., Barkhof, M. S. F., Tas, M. W., Baron, P. L., Constantin, C., Cassatella, M. A., Langdon, D. W., Webb, S., Gasparini, P., Zeviani, A., Kidd, D., Mammi, S., Cahalon, L., Hershkoviz, R., Lahat, N., Wallach, D., Annunziata, P., Martino, T., Maimone, D., Guazzi, G. C., Porrini, A. M., Dell'Arciprete, L., Rothwell, P. M., Stewart, R. R. C., Cull, R. E., Willmes, K., Poeck, K., Russell, D., Braekken, S. K., Brucher, R., Svennevig, J., Hermesl, M., Bruckmann, H., Biraben, A., Sliwka, U., Meyer, B., Schondube, F., Noth, J., Lavenu, I., Lammers, C., Waldecker, B., Haberbosch, W., Stam, J., Schneider, R., Gautier, J. C., Berlit, T. P., Fauser, B., Kuhne, D., Geraud, G., Danielli, A., Larrue, V., Bes, A., Timmerman, E., Bono, F., Bruni, A. C., Valalentino, P., Montesi, M. P., Talerico, G., Zappia, M., Sabatelli, M., Quattrone, A., Pareyson, D., Lorenzetti, D., Sghirlanzoni, A., Castellotti, B., Lupski, J. R., Archidiacono, N., Antonacci, R., Marzella, R., Rocchi, M., Samuel, D., Goulon-Goeau, C., Costa, P. P., Bismuth, H., Said, G., De Jongh P., Lofgren A., Timmerman V., Vance J. M., Van Broeckhoven C., Martin J. -J., Martinez, A. Cruz, Bort, S., Arpa, J., Misra, P., King, R. H. M., Badhia, K., Anderson, M., Caballo, A., Vichez, J., Gabriel, J. M., Erne, B., Miescher, G. C., Ulrich, J., Vital, A., Vital, C., Steck, A., Petry, K., Labatut, I., Hilmi, S., Ellie, E., Ferrini-Strambi, L., Zucconl, M., Marchettini, P., Palazzi, S., Oehlschlager, M., Pepinsky, R. B., Gemignani, F., Marbini, A., Pavesi, G., Di Vittorio, S., Manganelli, P., Mancia, D., Vermersh, P., Roche, J., Durocher, A. M., Dewailly, Ph., Dettmers, C., Fink, G., Lemon, R., Stephan, K., Passingham, D., Weder, B., Knorr, U., Huang, Y., Butterfield, D. A., Peris, M. L., Peiro, C., Pascual, A. Pascual-Leone, Bottini, G., Folnegovic-Smalc, V., Knezevic, S., Bokonjic, R., Ersmark, B., Torres, M. Gonzalez, Guiraud-Chaumeil, B., Haugaard, K., Jovicic, A., Chr, Lang, Levic, Z., Parra, C. Martinez, Ochoa, J. Patrignani, Titlbach, O., Wikkelso, C., Caparros-Lefevre, D., Debachy, B., Verier, A., Cantinho, G., Santos, A. I., Godinho, F., Bagunya, J., Roig, T., Ensenyat, A., Santiag, O., Trabucchi, H., De Leo, D., Koch, Ch., Zeumer, H., Matkovic, Z., Morris, P., Donaghy, M., Köhler, W., Kammer, T., Röther, J., Navon, R., Fontaine, B., Wu, Y., Capdevila, A., Guardiola, M. J., van Dijk, G. W., Notermans, N. C., Kruize, A. A., Kater, L., Bertelt, C., Hesse, S., Friedrich, H., Mauritz, K. -H., Giron, L. T., Watanabe, I. S., Ewing, D., Koepp, M., Lempert, T., Sander, B., Kauerz, U., Mehdorn, H. M., Hezel, J., Eickhoff, W., Kryst, T., Timsit, S., Gardeur, D., Reis, Mitermayer Galvao dos, Secor, E., Filho, A. Andrade, Silva, M. Cardoso, Santos, S. R. Silveira, Vasilaski, G., Reis, E. A. dos, Velupillai, P., Harn, D. A., Tigera, J. Garcia, Dreke, R. Martinez, Crespo, R. Piedra, Besses, C., Acin, P., Massons, J., Florensa, L., Oliveres, M., Sans-Sabrafen, J., Wicklein, E. M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
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- 1994
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17. Allelic repertoire of the human MICB gene
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Pellet, Phillipe, Renaud, Marc, Fodil, Nassima, Laloux, Laurent, Inoko, Hidetoshi, Hauptmann, Georges, Debré, Patrice, Bahram, Seiamak, and Theodorou, I.
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- 1997
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18. CC-chemokine receptor variants, SDF-1 polymorphism, and disease progression in 720 HIV-infected patient
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Meyer, L., Magierowska, M., Hubert, J-B., Theodorou, I., van Rij, R., Prins, M., de Roda Husman, A-M., Coutinho, R., and Schuitemaker, H.
- Published
- 1999
19. MIC genes in non-human primates
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Pellet, P., Vaneensberghe, C., Debré, P., Sumyuen, M. H., and Theodorou, I.
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- 1999
20. Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes
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Gonzalez Carter, DA, Leo, BF, Ruenraroengsak, P, Chen, S, Goode, A, Theodorou, I, Chung, KF, Carzaniga, R, Shaffer, M, Dexter, D, Ryan, M, and Porter, A
- Subjects
Lipopolysaccharides ,Neurons ,Silver ,Cell Survival ,Cystathionine gamma-Lyase ,Metal Nanoparticles ,Models, Biological ,Article ,Gene Expression Regulation, Enzymologic ,Cell Line ,Mice ,Oxidative Stress ,Animals ,Encephalitis ,Neurotoxicity Syndromes ,Hydrogen Sulfide ,Microglia - Abstract
Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson’s disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity. In the present study, the in vitro uptake and intracellular transformation of citrate-capped AgNPs by microglia, as well as their effects on microglial inflammation and related neurotoxicity were examined. Analytical microscopy demonstrated internalization and dissolution of AgNPs within microglia and formation of non-reactive silver sulphide (Ag2S) on the surface of AgNPs. Furthermore, AgNP-treatment up-regulated microglial expression of the hydrogen sulphide (H2S)-synthesizing enzyme cystathionine-γ-lyase (CSE). In addition, AgNPs showed significant anti-inflammatory effects, reducing lipopolysaccharide (LPS)-stimulated ROS, nitric oxide and TNFα production, which translated into reduced microglial toxicity towards dopaminergic neurons. Hence, the present results indicate that intracellular Ag2S formation, resulting from CSE-mediated H2S production in microglia, sequesters Ag+ ions released from AgNPs, significantly limiting their toxicity, concomitantly reducing microglial inflammation and related neurotoxicity.
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- 2017
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21. Cell structure and microtubule organisation during gametogenesis of Ulva mutabilis Føyn (Chlorophyta)
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Katsaros, C. Weiss, A. Llangos, I. Theodorou, I. Wichard, T.
- Abstract
Cell structure and microtubule organisation during gametogenesis of the green alga Ulva mutabilis was studied using light microscopy, transmission electron microscopy (TEM) and tubulin immunofluorescence. Microtubules in vegetative cells are organised in parallel bundles traversing the cortical cytoplasm. During gametogenesis, induced blade cells are transformed to gametangia, depending on the maturity of the algae and the removal of regulatory sporulation inhibitors. This differentiation is accompanied by formation of a conical cell projection (papilla) towards the exterior of the thallus. Microtubules form a clear, basket-like configuration converging towards the conical tip, but not reaching it. The conical microtubule structure stops below the tip, leaving a circular "opening". Parallel to the above, the cell wall of the tip is differentiated, forming a "cap". Nuclear divisions start at this stage, finally forming the nuclei of future gametes. Cytokinesis takes place by membrane furrowing and vesicle fusion, giving rise to 16 oval-shaped gametes. The conical microtubule organisation is gradually depolymerised, and a cortical, intensely fluorescing microtubule bundle is formed in each gamete. At this stage, the cap at the conical cell wall projection is removed and the exit pore opens. The biflagellate gametes remain initially motionless, connected by thin cytoplasmic bridges. Finally, they are released to the environment upon additional removal of a swarming inhibitor accumulated in the growth medium during gametogenesis. © 2017 Walter de Gruyter GmbH, Berlin/Boston.
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- 2017
22. AB0001 First description and functional proteomic analysis of a protective for rheumatoid arthritis gene polymorphism
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Sarantopoulos, A, primary, Theodorou, I, additional, Notopoulos, A, additional, Koulas, I, additional, and Boura, P, additional
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- 2017
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23. Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors
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Pang, J., primary, Theodorou, I. G., additional, Centeno, A., additional, Petrov, P. K., additional, Alford, N. M., additional, Ryan, M. P., additional, and Xie, F., additional
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- 2017
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- View/download PDF
24. Successful response in a case of severe pustular psoriasis after interleukin‐1β inhibition
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Skendros, P., primary, Papagoras, C., additional, Lefaki, I., additional, Giatromanolaki, A., additional, Kotsianidis, I., additional, Speletas, M., additional, Bocly, V., additional, Theodorou, I., additional, Dalla, V., additional, and Ritis, K., additional
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- 2016
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25. Significant metal enhanced fluorescence of Ag2S quantum dots in the second near-infrared window
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Theodorou, I. G., primary, Jawad, Z. A. R., additional, Qin, H., additional, Aboagye, E. O., additional, Porter, A. E., additional, Ryan, M. P., additional, and Xie, F., additional
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- 2016
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- View/download PDF
26. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
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McLaren, P.J., Coulonges, C., Bartha, I., Lenz, T.L., Deutsch, A.J., Bashirova, A., Buchbinder, S., Carrington, M.N., Cossarizza, A., Dalmau, J., De Luca, A., Goedert, J.J., Gurdasani, D., Haas, D.W., Herbeck, J.T., Johnson, E.O., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., Poli, G., Sandhu, M.S., Schuitemaker, H., Shea, P.R., Theodorou, I., Walker, B.D., Weintrob, A.C., Winkler, C.A., Wolinsky, S.M., Raychaudhuri, S., Goldstein, D.B., Telenti, A., de Bakker, P.I.W., Zagury, J-F, Fellay, J., McLaren, P.J., Coulonges, C., Bartha, I., Lenz, T.L., Deutsch, A.J., Bashirova, A., Buchbinder, S., Carrington, M.N., Cossarizza, A., Dalmau, J., De Luca, A., Goedert, J.J., Gurdasani, D., Haas, D.W., Herbeck, J.T., Johnson, E.O., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., Poli, G., Sandhu, M.S., Schuitemaker, H., Shea, P.R., Theodorou, I., Walker, B.D., Weintrob, A.C., Winkler, C.A., Wolinsky, S.M., Raychaudhuri, S., Goldstein, D.B., Telenti, A., de Bakker, P.I.W., Zagury, J-F, and Fellay, J.
- Abstract
Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. By combining the majority of available genome-wide genotyping data in HIV-infected populations, we tested for association between ∼8 million variants and viral load (HIV RNA copies per milliliter of plasma) in 6,315 individuals of European ancestry. The strongest signal of association was observed in the HLA class I region that was fully explained by independent effects mapping to five variable amino acid positions in the peptide binding grooves of the HLA-B and HLA-A proteins. We observed a second genome-wide significant association signal in the chemokine (C-C motif) receptor (CCR) gene cluster on chromosome 3. Conditional analysis showed that this signal could not be fully attributed to the known protective CCR5Δ32 allele and the risk P1 haplotype, suggesting further causal variants in this region. Heritability analysis demonstrated that common human genetic variation—mostly in the HLA and CCR5 regions—explains 25% of the variability in viral load. This study suggests that analyses in non-European populations and of variant classes not assessed by GWAS should be priorities for the field going forward.
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- 2015
27. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
- Author
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McLaren, PJ, Coulonges, C, Bartha, I, Lenz, TL, Deutsch, AJ, Bashirova, A, Buchbinder, S, Carrington, MN, Cossarizza, A, Dalmau, J, DE LUCA, ANDREA, Goedert, JJ, Gurdasani, D, Haas, DW, Herbeck, JT, Johnson, EO, Kirk, GD, Lambotte, O, Luo, M, Mallal, S, van Manen, D, Martinez-Picado, J, Meyer, L, Miro, JM, Mullins, JI, Obel, N, Poli, G, Sandhu, MS, Schuitemaker, H, Shea, PR, Theodorou, I, Walker, BD, Weintrob, AC, Winkler, CA, Wolinsky, SM, Raychaudhuri, S, Goldstein, DB, Telenti, A, de Bakker, PIW, Zagury, J, Fellay, J, McLaren, PJ, Coulonges, C, Bartha, I, Lenz, TL, Deutsch, AJ, Bashirova, A, Buchbinder, S, Carrington, MN, Cossarizza, A, Dalmau, J, DE LUCA, ANDREA, Goedert, JJ, Gurdasani, D, Haas, DW, Herbeck, JT, Johnson, EO, Kirk, GD, Lambotte, O, Luo, M, Mallal, S, van Manen, D, Martinez-Picado, J, Meyer, L, Miro, JM, Mullins, JI, Obel, N, Poli, G, Sandhu, MS, Schuitemaker, H, Shea, PR, Theodorou, I, Walker, BD, Weintrob, AC, Winkler, CA, Wolinsky, SM, Raychaudhuri, S, Goldstein, DB, Telenti, A, de Bakker, PIW, Zagury, J, and Fellay, J
- Published
- 2015
28. Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung
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López-Heras, M., primary, Theodorou, I. G., additional, Leo, B. F., additional, Ryan, M. P., additional, and Porter, A. E., additional
- Published
- 2015
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29. A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)
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Dragavon, J, Sinow, C, Holland, AD, Rekiki, A, Theodorou, I, Samson, C, Blazquez, S, Rogers, KL, Tournebize, R, Shorte, SL, Dragavon, J, Sinow, C, Holland, AD, Rekiki, A, Theodorou, I, Samson, C, Blazquez, S, Rogers, KL, Tournebize, R, and Shorte, SL
- Abstract
Fluorescence by Unbound Excitation from Luminescence (FUEL) is a radiative excitation-emission process that produces increased signal and contrast enhancement in vitro and in vivo. FUEL shares many of the same underlying principles as Bioluminescence Resonance Energy Transfer (BRET), yet greatly differs in the acceptable working distances between the luminescent source and the fluorescent entity. While BRET is effectively limited to a maximum of 2 times the Förster radius, commonly less than 14 nm, FUEL can occur at distances up to µm or even cm in the absence of an optical absorber. Here we expand upon the foundation and applicability of FUEL by reviewing the relevant principles behind the phenomenon and demonstrate its compatibility with a wide variety of fluorophores and fluorescent nanoparticles. Further, the utility of antibody-targeted FUEL is explored. The examples shown here provide evidence that FUEL can be utilized for applications where BRET is not possible, filling the spatial void that exists between BRET and traditional whole animal imaging.
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- 2014
30. Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome
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Milionis, H. J., Kostapanos, M. S., Vakalis, K., Theodorou, I., Bouba, I., Kalaitzidis, R., Georgiou, I., Elisaf, M. S., and Siamopoulos, K. C.
- Subjects
Male ,Polymorphism, Genetic ,Genotype ,Greece/epidemiology ,Middle Aged ,Renin-Angiotensin System/*genetics ,Treatment Outcome ,Hypertension/*complications/*drug therapy/genetics ,Metabolic Syndrome X/*complications/*drug therapy/epidemiology/genetics ,Prevalence ,Humans ,Regression Analysis ,Female ,Demography - Abstract
OBJECTIVE: To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS). METHODS: Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg. RESULTS: Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS. The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors. CONCLUSIONS: RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies. J Renin Angiotensin Aldosterone Syst
- Published
- 2007
31. A natural CCL5/RANTES variant antagonist for CCR1 and CCR3
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Capoulade-Métay, C., Ayouba, Ahidjo, Kfutwah, A., Lole, K., Pêtres, S., Dudoit, Y., Deterre, P., Menu, E., Barré-Sinoussi, F., Debré, P., Theodorou, I., Depienne, C., Nerrienet, E., Dormont, D., Brun-Vezinet, F., Simon, F., and Mauclère, P.
- Subjects
CYTOKINE ,MALADIE ,SIDA ,MALADIE AUTOIMMUNE ,PROTEINE ,ADN ,INFECTION ,REGULATION ,POLYMORPHISME GENETIQUE ,EXPRESSION DES GENES ,IMMUNITE - Published
- 2006
32. Combined Linkage and Association Studies of Antibodies against EBV Antigens Confirm the Role of HLA Class II Variants in the Control of Anti-EBNA1 IgG Levels and in the Risk of Hodgkin's Lymphoma
- Author
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Pedergnana, V, primary, Syx, L, additional, Cobat, A, additional, Guergnon, J, additional, Brice, P, additional, Ferme, C, additional, Carde, P, additional, Hermine, O, additional, Le Pendeven, C, additional, Amiel, C, additional, Theodorou, I, additional, Abel, L, additional, and Besson, C, additional
- Published
- 2014
- Full Text
- View/download PDF
33. Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection
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Mulherin, S. A., O'Brien, T. R., Ioannidis, J. P., Goedert, J. J., Buchbinder, S. P., Coutinho, R. A., Jamieson, B. D., Meyer, L., Michael, N. L., Pantaleo, G., Rizzardi, G. P., Schuitemaker, H., Sheppard, H. W., Theodorou, I. D., Vlahov, D., and Rosenberg, P. S.
- Subjects
Heterozygote ,Receptors, Chemokine/*genetics ,Time Factors ,HIV Seropositivity/genetics ,Receptors, CCR2 ,Disease Progression ,Humans ,Polymorphism, Genetic/genetics ,HIV-1/*genetics ,Survival Analysis ,Acquired Immunodeficiency Syndrome/*genetics ,Receptors, CCR5/*genetics ,Proportional Hazards Models - Abstract
OBJECTIVE: To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression. DESIGN: Pooled analysis of individual patient data from 10 cohorts of HIV-1 seroconverters from the United States, Europe, and Australia. METHODS: We studied HIV-1 seroconverters of European (n = 1635) or African (n = 215) ancestry who had been genotyped for CCR5-Delta32 and CCR2-64I. We used Cox proportional hazards models with time-varying coefficients to determine whether the genetic protection against AIDS (1987 case definition) and death varied with time since seroconversion. RESULTS: Protection against AIDS conferred by CCR5-Delta32 held constant at a 31% (RH 0.69, 95% CI 0.54, 0.88) reduction in risk over the course of HIV-1 infection, whereas protection against death held constant at a 39% reduction in risk (RH 0.61, 95% CI 0.45, 0.88). When the period from AIDS to death was isolated, the survival benefit of CCR5-Delta32 diminished 2 years after AIDS. Protection against AIDS conferred by CCR2-64I was greatest early in the disease course. Compared with individuals without CCR5-Delta32 or CCR2-64I, individuals with one or two copies of CCR2-64I had a 58% lower risk of AIDS during the first 4 years after seroconversion (RH 0.42, 95% CI 0.23, 0.76), a 19% lower risk during the subsequent 4 years (RH 0.81, 95% CI 0.59, 1.12), and no significant protection thereafter. CONCLUSION: The protection against AIDS provided by CCR5-Delta32 is continuous during the course of infection. In contrast, the protection provided by CCR2-64I is greatest early in the course of infection. AIDS
- Published
- 2003
34. Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls
- Author
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Balloux, F., McLaren, P.J., Coulonges, C., Ripke, S., van den Berg, L., Buchbinder, S., Carrington, M., Cossarizza, A., Dalmau, J., Deeks, S.G., Delaneau, O., De Luca, A., Goedert, J.J., Haas, D., Herbeck, J.T., Kathiresan, S., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., O'Brien, S.J., Pereyra, F., Plummer, F.A., Poli, G., Qi, Y., Rucart, P., Sandhu, M.S., Shea, P.R., Schuitemaker, H., Theodorou, I., Vannberg, F., Veldink, J., Walker, B.D., Weintrob, A., Winkler, C.A., Wolinsky, S., Telenti, A., Goldstein, D.B., de Bakker, P.I.W., Zagury, J-F, Fellay, J., Balloux, F., McLaren, P.J., Coulonges, C., Ripke, S., van den Berg, L., Buchbinder, S., Carrington, M., Cossarizza, A., Dalmau, J., Deeks, S.G., Delaneau, O., De Luca, A., Goedert, J.J., Haas, D., Herbeck, J.T., Kathiresan, S., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., O'Brien, S.J., Pereyra, F., Plummer, F.A., Poli, G., Qi, Y., Rucart, P., Sandhu, M.S., Shea, P.R., Schuitemaker, H., Theodorou, I., Vannberg, F., Veldink, J., Walker, B.D., Weintrob, A., Winkler, C.A., Wolinsky, S., Telenti, A., Goldstein, D.B., de Bakker, P.I.W., Zagury, J-F, and Fellay, J.
- Abstract
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is known to tag the HLA-B*57:01 and B*27:05 alleles, as genome-wide significant (p = 3.6×10−11). However, restricting analysis to individuals with a known date of seroconversion suggested that this association was due to the frailty bias in studies of lethal diseases. Further analyses including testing recessive genetic models, testing for bulk effects of non-genome-wide significant variants, stratifying by sexual or parenteral transmission risk and testing previously reported associations showed no evidence for genetic influence on HIV-1 acquisition (with the exception of CCR5Δ32 homozygosity). Thus, these data suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.
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- 2013
35. Effects of CCR5-Δ32, CCR2-64I, and SDF-1 3′ a alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
- Author
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Ioannidis, J. P. A., Rosenberg, P. S., Goedert, J. J., Ashton, L. J., Benfield, T. L., Buchbinder, S. P., Coutinho, R. A., Eugen-Olsen, J., Gallart, T., Katzenstein, T. L., Kostrikis, Leontios G., Kuipers, H., Louie, L. G., Mallal, S. A., Margolick, J. B., Martinez, O. P., Meyer, L., Michael, N. L., Operskalski, E., Pantaleo, G., Rizzardi, G. P., Schuitemaker, H., Sheppard, H. W., Stewart, G. J., Theodorou, I. D., Ullum, H., Vicenzi, E., Vlahov, D., Wilkinson, D., Workman, C., Zagury, J. -F, O'Brien, T. R., and Kostrikis, Leontios G. [0000-0002-5340-7109]
- Subjects
chemokine receptor CCR5 ,Receptors, CCR5 ,proportional hazards model ,chemokine receptor CCR2 ,Human immunodeficiency virus 1 ,HIV Infections ,monocyte chemoattractant protein 1 receptor ,genetic risk ,acquired immune deficiency syndrome ,regression analysis ,Human immunodeficiency virus infection ,Humans ,genetics ,stromal cell derived factor 1 ,human ,seroconversion ,Alleles ,Proportional Hazards Models ,Acquired Immunodeficiency Syndrome ,alpha chemokine ,disease course ,disease association ,article ,allele ,risk assessment ,chemokine receptor ,clinical trial ,major clinical study ,mortality ,heterozygote ,priority journal ,Disease Progression ,HIV-1 ,RNA ,Receptors, Chemokine ,metabolism ,disease activity ,Chemokines, CXC ,meta analysis - Abstract
Background: Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results. Objective: To examine postulated associations of genetic alleles with HIV-1 disease progression. Design: Meta-analysis of individual-patient data. Setting: 19 prospective cohort studies and case-control studies from the United States, Europe, and Australia. Patients: Patients with HIV-1 infection who were of European or African descent. Measurements: Time to AIDS, death, and death after AIDS and HIV-1 RNA level at study entry or soon after seroconversion. Data were combined with fixed-effects and random-effects models. Results: Both the CCR5-Δ32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS (relative hazard among seroconverters, 0.74 and 0.76, respectively P = 0.01 for both), a decreased risk for death (relative hazard among seroconverters, 0.64 and 0.74 P < 0.05 for both), and lower HIV-1 RNA levels after seroconversion (difference, -0.18 log10 copies/mL and -0.14 log10 copies/mL P < 0.05 for both). Having the CCR5-Δ32 or CCR2-64I allele had no clear protective effect on the risk for death after development of AIDS. The results were consistent between seroconverters and seroprevalent patients. In contrast, SDF-1 3′A homozygotes showed no decreased risk for AIDS (relative hazard for seroconverters and seroprevalent patients, 0.99 and 1.03, respectively), death (relative hazard, 0.97 and 1.00), or death after development of AIDS (relative hazard, 0.81 and 0.97 P < 0.5 for all). Conclusions: The CCR5-Δ32 and CCR2-64I alleles had a strong protective effect on progression of HIV-1 infection, but SDF-1 3′A homozygosity carried no such protection. 135 782 795 Cited By :238
- Published
- 2001
36. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
- Author
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Hor, H., Kutalik, Z., Dauvilliers, Y., Valsesia, A., Lammers, G.J., Donjacour, C.E., Iranzo, A., Santamaria, J., Peraita Adrados, R., Vicario, J.L., Overeem, S., Arnulf, I., Theodorou, I., Jennum, P., Knudsen, S., Bassetti, C., Mathis, J., Lecendreux, M., Mayer, G., Geisler, P., Beneto, A., Petit, B., Pfister, C., Burki, J.V., Didelot, G., Billiard, M., Ercilla, G., Verduijn, W., Claas, F.H., Vollenwider, P., Waeber, G., Waterworth, D.M., Mooser, V., Heinzer, R., Beckmann, J.S., Bergmann, S., Tafti, M., Hor, H., Kutalik, Z., Dauvilliers, Y., Valsesia, A., Lammers, G.J., Donjacour, C.E., Iranzo, A., Santamaria, J., Peraita Adrados, R., Vicario, J.L., Overeem, S., Arnulf, I., Theodorou, I., Jennum, P., Knudsen, S., Bassetti, C., Mathis, J., Lecendreux, M., Mayer, G., Geisler, P., Beneto, A., Petit, B., Pfister, C., Burki, J.V., Didelot, G., Billiard, M., Ercilla, G., Verduijn, W., Claas, F.H., Vollenwider, P., Waeber, G., Waterworth, D.M., Mooser, V., Heinzer, R., Beckmann, J.S., Bergmann, S., and Tafti, M.
- Abstract
1 september 2010, Contains fulltext : 88508.pdf (publisher's version ) (Closed access), Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 haplotype is common in the general population (15-25%), it has been suggested that it is almost necessary but not sufficient for developing narcolepsy. To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS) in 562 European individuals with narcolepsy (cases) and 702 ethnically matched controls, with independent replication in 370 cases and 495 controls, all heterozygous for DRB1*1501-DQB1*0602. We found association with a protective variant near HLA-DQA2 (rs2858884; P < 3 x 10(-8)). Further analysis revealed that rs2858884 is strongly linked to DRB1*03-DQB1*02 (P < 4 x 10(-43)) and DRB1*1301-DQB1*0603 (P < 3 x 10(-7)). Cases almost never carried a trans DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 x 10(-14)). This unexpected protective HLA haplotype suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility.
- Published
- 2010
37. Caractéristiques des patients HIV controllers : résultats de la cohorte ANRS CO18
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Noel, N., primary, Boufassa, F., additional, Lecuroux, C., additional, Saez-Cirion, A., additional, Meyer, L., additional, Pancino, G., additional, Rouzioux, C., additional, Theodorou, I., additional, Venet, A., additional, and Lambotte, O., additional
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- 2013
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38. 1429 BASELINE APOLIPOPROTEIN H (ApoH) IS A PREDICTOR OF EARLY VIROLOGIC RESPONSE TO TRIPLE THERAPY (ANRS CO20-CUPIC)
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Sultanik, P., primary, Mallet, V., additional, Dorival-Mouly, C., additional, Barthe, Y., additional, Fonaine, H., additional, Hézode, C., additional, Mottez, E., additional, Bronowicki, J.-P., additional, Carrat, F., additional, Gayat, E., additional, Casrouge, A., additional, Fontanet, A., additional, Theodorou, I., additional, Abel, L., additional, Pol, S., additional, and Albert, M., additional
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- 2013
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39. L’apport de la génétique de l’hôte dans la maladie VIH
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Bouthemy, C., primary, Nel, I., additional, Oudot Mellakh, T., additional, and Theodorou, I., additional
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- 2013
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40. Significant metal enhanced fluorescence of Ag2S quantum dots in the second near-infrared window.
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Theodorou, I. G., Jawad, Z. A. R., Qin, H., Aboagye, E. O., Porter, A. E., Ryan, M. P., and Xie, F.
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- 2016
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41. In vivo excitation of nanoparticles using luminescent bacteria
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Dragavon, J., primary, Blazquez, S., additional, Rekiki, A., additional, Samson, C., additional, Theodorou, I., additional, Rogers, K. L., additional, Tournebize, R., additional, and Shorte, S. L., additional
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- 2012
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42. 1401 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES VARIANTS ASSOCIATED WITH LIVER FIBROSIS PROGRESSION IN HCV-INFECTED PATIENTS
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Patin, E., primary, Kutalik, Z., additional, Guergnon, J., additional, Bibert, S., additional, Nalpas, B., additional, Jouanguy, E., additional, Munteanu, M., additional, Bousquet, L., additional, Argiro, L., additional, Halfon, P., additional, Boland, A., additional, Mullhaupt, B., additional, Semela, D., additional, Dufour, J.-F., additional, Heim, M.H., additional, Moradpour, D., additional, Cerny, A., additional, Malmvemi, R., additional, Hirsch, H., additional, Martinetti, G., additional, Suppiah, V., additional, Stewart, G., additional, Booth, D.R., additional, George, J., additional, Casanova, J.-L., additional, Brechot, C., additional, Rice, C.M., additional, Talal, A.H., additional, Jacobson, I.M., additional, Bourliere, M., additional, Theodorou, I., additional, Poynard, T., additional, Negro, F., additional, Pol, S., additional, Abel, L., additional, and Bochud, P.-Y., additional
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- 2012
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43. Single-Nucleotide Polymorphism–Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection
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Guergnon, J., primary, Dalmasso, C., additional, Broet, P., additional, Meyer, L., additional, Westrop, S. J., additional, Imami, N., additional, Vicenzi, E., additional, Morsica, G., additional, Tinelli, M., additional, Zanone Poma, B., additional, Goujard, C., additional, Potard, V., additional, Gotch, F. M., additional, Casoli, C., additional, Cossarizza, A., additional, Macciardi, F., additional, Debré, P., additional, Delfraissy, J. F., additional, Galli, M., additional, Autran, B., additional, Costagliola, D., additional, Poli, G., additional, Theodorou, I., additional, and Riva, A., additional
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- 2012
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44. P16-45. High avidity CD4+ T cell response directed to an immunodominant Gag epitope in HIV controllers: an ANRS EP36 study
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Vingert, B, primary, Perez-Patrigeon, S, additional, Jeannin, P, additional, Lambotte, O, additional, Boufassa, F, additional, Lemaître, F, additional, Kwok, WK, additional, Theodorou, I, additional, Delfraissy, J, additional, Thèze, J, additional, and Chakrabarti, LA, additional
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- 2009
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45. La maladie d’Erdheim-Chester s’associe préférentiellement aux allèles HLA-A30 et -DRB1*11
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Arnaud, L., primary, Haroche, J., additional, Boudifa, A., additional, Pérard, L., additional, Rigolet, A., additional, Vital-Durand, D., additional, Ninet, J., additional, Herson, S., additional, Theodorou, I., additional, Piette, J.C., additional, and Amoura, Z., additional
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- 2009
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46. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression:An international meta-analysis of individual-patient data
- Author
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Ioannidis, J P, Rosenberg, P S, Goedert, J J, Ashton, L J, Benfield, T L, Buchbinder, S P, Coutinho, R A, Eugen-Olsen, J, Gallart, T, Katzenstein, T L, Kostrikis, L G, Kuipers, H, Louie, L G, Mallal, S A, Margolick, J B, Martinez, O P, Meyer, L, Michael, N L, Operskalski, E, Pantaleo, G, Rizzardi, G P, Schuitemaker, H, Sheppard, H W, Stewart, G J, Theodorou, I D, Ullum, H, Vicenzi, E, Vlahov, D, Wilkinson, D, Workman, C, Zagury, J F, O'Brien, T R, Ioannidis, J P, Rosenberg, P S, Goedert, J J, Ashton, L J, Benfield, T L, Buchbinder, S P, Coutinho, R A, Eugen-Olsen, J, Gallart, T, Katzenstein, T L, Kostrikis, L G, Kuipers, H, Louie, L G, Mallal, S A, Margolick, J B, Martinez, O P, Meyer, L, Michael, N L, Operskalski, E, Pantaleo, G, Rizzardi, G P, Schuitemaker, H, Sheppard, H W, Stewart, G J, Theodorou, I D, Ullum, H, Vicenzi, E, Vlahov, D, Wilkinson, D, Workman, C, Zagury, J F, and O'Brien, T R
- Abstract
BACKGROUND: Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results.OBJECTIVE: To examine postulated associations of genetic alleles with HIV-1 disease progression.DESIGN: Meta-analysis of individual-patient data.SETTING: 19 prospective cohort studies and case-control studies from the United States, Europe, and Australia.PATIENTS: Patients with HIV-1 infection who were of European or African descent.MEASUREMENTS: Time to AIDS, death, and death after AIDS and HIV-1 RNA level at study entry or soon after seroconversion. Data were combined with fixed-effects and random-effects models.RESULTS: Both the CCR5-Delta32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS (relative hazard among seroconverters, 0.74 and 0.76, respectively; P = 0.01 for both), a decreased risk for death (relative hazard among seroconverters, 0.64 and 0.74; P < 0.05 for both), and lower HIV-1 RNA levels after seroconversion (difference, -0.18 log(10) copies/mL and -0.14 log(10) copies/mL; P < 0.05 for both). Having the CCR5-Delta32 or CCR2-64I allele had no clear protective effect on the risk for death after development of AIDS. The results were consistent between seroconverters and seroprevalent patients. In contrast, SDF-1 3'A homozygotes showed no decreased risk for AIDS (relative hazard for seroconverters and seroprevalent patients, 0.99 and 1.03, respectively), death (relative hazard, 0.97 and 1.00), or death after development of AIDS (relative hazard, 0.81 and 0.97; P > 0.5 for all).CONCLUSIONS: The CCR5-Delta32 and CCR2-64I alleles had a strong protective effect on progression of HIV-1 infection, but SDF-1 3'A homozygosity carried no such protection.
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- 2001
47. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
- Author
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Ioannidis, J P, Rosenberg, Peter, Goedert, J J, Ashton, L J, Benfield, Thomas, Buchbinder, S P, Coutinho, R A, Eugen-Olsen, J, Gallart, T, Katzenstein, T L, Kostrikis, L G, Kuipers, H, Louie, L G, Mallal, S A, Margolick, J B, Martinez, O P, Meyer, L, Michael, N L, Operskalski, E, Pantaleo, G, Rizzardi, G P, Schuitemaker, H, Sheppard, H W, Stewart, G J, Theodorou, I D, Ullum, H, Vicenzi, E, Vlahov, D, Wilkinson, D, Workman, Christopher, Zagury, J F, O'Brien, T R, Ioannidis, J P, Rosenberg, Peter, Goedert, J J, Ashton, L J, Benfield, Thomas, Buchbinder, S P, Coutinho, R A, Eugen-Olsen, J, Gallart, T, Katzenstein, T L, Kostrikis, L G, Kuipers, H, Louie, L G, Mallal, S A, Margolick, J B, Martinez, O P, Meyer, L, Michael, N L, Operskalski, E, Pantaleo, G, Rizzardi, G P, Schuitemaker, H, Sheppard, H W, Stewart, G J, Theodorou, I D, Ullum, H, Vicenzi, E, Vlahov, D, Wilkinson, D, Workman, Christopher, Zagury, J F, and O'Brien, T R
- Abstract
Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results.
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- 2001
48. Improved virological response to highly active antiretroviral therapy in HIV-1-infected patients carrying the CCR5 ?32 deletion
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Laurichesse, JJ, primary, Persoz, A, additional, Theodorou, I, additional, Rouzioux, C, additional, Delfraissy, JF, additional, and Meyer, L, additional
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- 2007
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49. Clinical and biological characteristics of human immunodeficiency virus-infected and uninfected intravascular drug users in Ho Chi Minh City, Vietnam.
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Follézou, J Y, primary, Lafon, M E, additional, Debré, P, additional, Delfraissy, J F, additional, Chi, N H, additional, Lan, N Y, additional, Aknine, X, additional, Fleury, H J, additional, Tram, L T, additional, Ngai, N V, additional, Lowenstein, W, additional, Lien, T X, additional, Hung, P V, additional, Theodorou, I, additional, and Barré-Sinoussi, F, additional
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- 1999
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50. Lack of association between human leukocyte antigens and anti-Hu syndrome in patients with small-cell lung cancer
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Tanaka, K., primary, Nakano, R., additional, Inuzuka, T., additional, Tsuji, S., additional, Shinozawa, K., additional, Kojo, T., additional, Mastui, T.-a., additional, Kumamoto, T., additional, Suzumura, A., additional, Theodorou, I., additional, Liblau, R., additional, Uchuya, M., additional, and Delattre, J.-Y., additional
- Published
- 1999
- Full Text
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