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6. A strain-programmed patch for the healing of diabetic wounds

Author

Theocharidis, Georgios, Yuk, Hyunwoo, Roh, Heejung, Wang, Liu, Mezghani, Ikram, Wu, Jingjing, Kafanas, Antonios, Contreras, Mauricio, Sumpio, Brandon, Li, Zhuqing, Wang, Enya, Chen, Lihong, Guo, Chuan Fei, Jayaswal, Navin, Katopodi, Xanthi-Leda, Kalavros, Nikolaos, Nabzdyk, Christoph S., Vlachos, Ioannis S., Veves, Aristidis, and Zhao, Xuanhe

Published
2022
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9. Single cell transcriptomic landscape of diabetic foot ulcers

Author

Theocharidis, Georgios, Thomas, Beena E., Sarkar, Debasree, Mumme, Hope L., Pilcher, William J. R., Dwivedi, Bhakti, Sandoval-Schaefer, Teresa, Sîrbulescu, Ruxandra F., Kafanas, Antonios, Mezghani, Ikram, Wang, Peng, Lobao, Antonio, Vlachos, Ioannis S., Dash, Biraja, Hsia, Henry C., Horsley, Valerie, Bhasin, Swati S., Veves, Aristidis, and Bhasin, Manoj

Published
2022
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12. Intelligent In situ Printing of Multimaterial Bioinks for First‐Aid Wound Care Guided by Eye‐In‐Hand Robot Technology

Author

Jeong, Seol‐Ha, primary, Kim, Jihyun, additional, Thibault, Brendan Craig, additional, Soto, Javier Alejandro Lozano, additional, Tourk, Fatima, additional, Steakelum, Joshua, additional, Azuela, Diego, additional, Carvalho, Violeta, additional, Quiroga‐Ocaña, Guillermo, additional, Zhuang, Weida, additional, Cham‐Pérez, Mei Li L., additional, Huang, Lucia L., additional, Li, Zhuqing, additional, Valsami, Eleftheria‐Angeliki, additional, Wang, Enya, additional, Rodrigues, Nelson, additional, Teixeira, Senhorinha F.C.F., additional, Lee, Yuhan, additional, Seo, Jungmok, additional, Veves, Aristidis, additional, Hassan, Shabir, additional, Theocharidis, Georgios, additional, Fiondella, Lance, additional, and Shin, Su Ryon, additional

Published
2024
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13. Dissecting the role of type VI collagen in skin function

Author

Theocharidis, Georgios

Abstract

Type VI collagen is a non-fibrillar collagen expressed in many connective tissues and implicated in extracellular matrix (ECM) organisation. Based on its interactions with many ECM molecules, it was hypothesized that type VI collagen regulates matrix assembly and cell function within the dermis of the skin. In the present thesis the expression pattern of type VI collagen in normal, diseased and wounded human or mouse skin was examined and the specific function of type VI collagen in new matrix deposition by human dermal fibroblasts was investigated. Type VI collagen was expressed throughout the dermis of intact human skin, at the expanding margins of human keloid samples, during stages of active ECM production in mouse embryonic development and in the granulation tissue of newly deposited ECM in a murine model of wound healing. Generation of cell derived matrices (CDMs) by human dermal fibroblasts with stable knockdown of COL6A1 revealed that type VI collagen depleted matrices were significantly thinner and contained more aligned, thicker, and widely spaced fibres than CDMs produced by normal fibroblasts. In addition, there was significantly less total collagen and sulfated glycosaminoglycans present in the type VI collagen deficient matrices. Normal fibroblasts cultured on de-cellularised CDMs lacking type VI collagen displayed increased cell spreading, migration speed, and persistence. Taken as a whole, these findings indicate that type VI collagen is a key mediator of dermal matrix assembly, composition, and fibroblast behaviour and may play an important role in wound healing and tissue regeneration processes.

Published
2016

21. MIAAIM: Multi-omics image integration and tissue state mapping using topological data analysis and cobordism learning

Author

Hess, Joshua M., primary, Ilieş, Iulian, additional, Schapiro, Denis, additional, Iskra, John J., additional, Abdelmoula, Walid M., additional, Regan, Michael S., additional, Theocharidis, Georgios, additional, Wu, Chin Lee, additional, Veves, Aristidis, additional, Agar, Nathalie Y.R., additional, Sluder, Ann E., additional, Poznansky, Mark C., additional, Reeves, Patrick M., additional, and Sîrbulescu, Ruxandra F., additional

Published
2021
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22. Strain-Programmable Patch for Diabetic Wound Healing

Author

Theocharidis, Georgios, primary, Yuk, Hyunwoo, additional, Roh, Heejung, additional, Wang, Liu, additional, Mezghani, Ikram, additional, Wu, Jingjing, additional, Kafanas, Antonios, additional, Chen, Lihong, additional, Guo, Chuan Fei, additional, Jayaswal, Navin, additional, Katopodi, Xanthi-Leda, additional, Nabzdyk, Christoph S., additional, Vlachos, Ioannis S., additional, Veves, Aristidis, additional, and Zhao, Xuanhe, additional

Published
2021
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23. Single Cell Transcriptomic Landscape of Diabetic Foot Ulcers

Author

Theocharidis, Georgios, primary, Thomas, Beena E., additional, Sarkar, Debasree, additional, Pilcher, William JR, additional, Dwivedi, Bhakti, additional, Sandoval-Schaefer, Teresa, additional, Sîrbulescu, Ruxandra F., additional, Kafanas, Antonios, additional, Mezghani, Ikram, additional, Wang, Peng, additional, Lobao, Antonio, additional, Vlachos, Ioannis, additional, Dash, Biraja, additional, Hsia, Henry C., additional, Horsley, Valerie, additional, Bhasin, Swati S., additional, Veves, Aristidis, additional, and Bhasin, Manoj, additional

Published
2021
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24. A Novel Three-Dimensional Skin Disease Model to Assess Macrophage Function in Diabetes

Author

Smith, Avi, primary, Watkins, Trishawna, additional, Theocharidis, Georgios, additional, Lang, Irene, additional, Leschinsky, Maya, additional, Maione, Anna, additional, Kashpur, Olga, additional, Raimondo, Theresa, additional, Rahmani, Sahar, additional, Baskin, Jeremy, additional, Mooney, David, additional, Veves, Aristidis, additional, and Garlick, Jonathan, additional

Published
2021
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25. Integrated skin transcriptomics and serum multiplex assays reveal novel mechanisms of wound healing in diabetic foot ulcers

Author

Admin, Ada, primary, Theocharidis, Georgios, primary, Baltzis, Dimitrios, primary, Roustit, Matthieu, primary, Tellechea, Ana, primary, Dangwal, Seema, primary, Khetani, Radhika S., primary, Shu, Bin, primary, Zhao, Wanni, primary, Fu, Jianfang, primary, Bhasin, Swati, primary, Kafanas, Antonios, primary, Hui, Daniel, primary, Sui, Shannan Ho, primary, Patsopoulos, Nikolaos A., primary, Bhasin, Manoj, primary, and Veves, Aristidis, primary

Published
2020
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26. Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers

Author

Theocharidis, Georgios, primary, Baltzis, Dimitrios, additional, Roustit, Matthieu, additional, Tellechea, Ana, additional, Dangwal, Seema, additional, Khetani, Radhika S., additional, Shu, Bin, additional, Zhao, Wanni, additional, Fu, Jianfang, additional, Bhasin, Swati, additional, Kafanas, Antonios, additional, Hui, Daniel, additional, Sui, Shannan Ho, additional, Patsopoulos, Nikolaos A., additional, Bhasin, Manoj, additional, and Veves, Aristidis, additional

Published
2020
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30. On skin substitutes for wound healing: Current products, limitations, and future perspectives.

Author

Kelangi, Sarah Susan, Theocharidis, Georgios, Veves, Aristidis, Austen, William G., Sheridan, Robert, Goverman, Jeremy, and Bei, Marianna

Subjects
WOUND healing, SKIN injuries, CHRONIC wounds & injuries, TEMPERATURE control
Abstract

Cutaneous wound healing is a highly coordinated process involving numerous molecular pathways that regulate the function of specific skin cell types. One of the key decisions in acute and/or chronic wound healing management is to choose the skin substitute that, based on its composition and/or properties, may act as permanent skin replacement or temporary wound cover. The current products however are limited in their action, especially in the context of large chronic wounds or extensive second-/third-degree burns, due to the risk of developing infection, the limited vascularization, the inability to integrate to host tissue, and the lack in the healed area of skin apparatus responsible for temperature control, pigmentation, immune regulation, and nerve supply. In addition, the high cost of skin substitutes precludes their use in small- and moderate-size burns because they are economically impractical and protract the time to definitive wound closure. Thus, the need to develop cost-effective substitutes of high quality is imperative. The purpose of this review is to discuss current available products, their limitations and to provide some perspectives on future research toward generation of cost-effective, high-quality substitutes. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Differentiation of diabetic foot ulcer–derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes

Author

Kashpur, Olga, primary, Smith, Avi, additional, Gerami-Naini, Behzad, additional, Maione, Anna G., additional, Calabrese, Rossella, additional, Tellechea, Ana, additional, Theocharidis, Georgios, additional, Liang, Liang, additional, Pastar, Irena, additional, Tomic-Canic, Marjana, additional, Mooney, David, additional, Veves, Aristidis, additional, and Garlick, Jonathan A., additional

Published
2018
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34. Minor collagens of the skin with not so minor functions.

Author

Theocharidis, Georgios and Connelly, John T.

Subjects
*COLLAGEN, *PROTEIN structure, *SKIN, *GROWTH factors, *MOLECULAR structure, *EXTRACELLULAR matrix
Abstract

The structure and function of the skin relies on the complex expression pattern and organisation of extracellular matrix macromolecules, of which collagens are a principal component. The fibrillar collagens, types I and III, constitute over 90% of the collagen content within the skin and are the major determinants of the strength and stiffness of the tissue. However, the minor collagens also play a crucial regulatory role in a variety of processes, including cell anchorage, matrix assembly, and growth factor signalling. In this article, we review the expression patterns, key functions and involvement in disease pathogenesis of the minor collagens found in the skin. While it is clear that the minor collagens are important mediators of normal tissue function, homeostasis and repair, further insight into the molecular level structure and activity of these proteins is required for translation into clinical therapies. [ABSTRACT FROM AUTHOR]

Published
2019
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39. Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure.

Author

Kaveti, Rajaram, Jakus, Margaret A., Chen, Henry, Jain, Bhavya, Kennedy, Darragh G., Caso, Elizabeth A., Mishra, Navya, Sharma, Nivesh, Uzunoğlu, Baha Erim, Won Bae Han, Tae-Min Jang, Suk-Won Hwang, Theocharidis, Georgios, Sumpio, Brandon J., Veves, Aristidis, Sia, Samuel K., and Bandodkar, Amay J.

Subjects
*CHRONIC wounds & injuries, *WOUNDS & injuries, *PSEUDOPOTENTIAL method, *ELECTRIC fields, *ELECTROTHERAPEUTICS, *POWER electronics
Abstract

Chronic wounds affect ~2% of the U.S. population and increase risks of amputation and mortality. Unfortunately, treatments for such wounds are often expensive, complex, and only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits its clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer a unique solution to this issue. The WPED performs even under harsh conditions--situations wherein many present treatments fail. It uses a flexible, biocompatible magnesium-silver/silver chloride battery and a pair of stimulation electrodes; upon the addition of water, the battery creates a radial electric field. Experiments in diabetic mice confirm the WPED's ability to accelerate wound closure and promote healing by increasing epidermal thickness, modulating inflammation, and promoting angiogenesis. Across preclinical wound models, the WPED-treated group heals faster than the control with wound closure rates comparable to treatments requiring expensive biologics and/or complex electronics. The results demonstrate the WPED's potential as an effective and more practical wound treatment dressing. [ABSTRACT FROM AUTHOR]

Published
2024
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