Search

An ion-associate phase (IAP) microextraction/ back-microextraction system was applied for the enrichment, separation, and detection of trace amounts of nickel from environmental water samples. Thenoyltrifluoroacetone (HTTA) acted not only as a chelating reagent for nickel, but also as a component of the extraction phase, i.e., IAP. Nickel in a 40 mL sample solution was pH-adjusted with phenolsulfonate (PS−) and tetramethylammonium hydroxide and converted by chelation reaction in the presence of thenoyltrifluoroacetonate (TTA−). When benzyldodecyldimethylammonium ion (C12BzDMA+) was added, a suspension of IAP formed in the solution. The IAP consisted of TTA−, a chelating reagent, the PS−, a component of pH buffer, and C12BzDMA+, which helps extract the chelating complex. When the solution was centrifuged, the IAP separated from the suspension and the nickel-TTA chelate was extracted into the bottom phase of the centrifuge tube. After the aqueous phase was taken away, 100 µL of nitric acid (2 M) solution containing phosphate was used to back-microextract nickel from the IAP. The acid phase was measured via graphite-furnace atomic-absorption spectrometry (GF-AAS). The proposed method facilitated a 400-fold enrichment. The limit of detection was 0.02 µg L−1. The proposed method was applied for the determination of nickel in river water and seawater samples.

The complex formation of protactinium(V) with ethylenediaminetetraacetic acid (EDTA) was studied at tracer concentration ([233Pa(V)] ~ 10−12 mol·L−1) by the solvent extraction technique at 25 °C, I = 1.0, and different acidities ([HClO4] = 1.0, 0.1, 0.025 mol·L−1). The aqueous phase employed for the solvent extraction experiment was Pa(V)/H2O/HClO4/NaClO4/EDTA at 25 °C for I = 1.0, and the organic phase was xylene with a chelating agent, thenoyltrifluoroacetone (TTA). A 1:1 complex between Pa(V) and EDTA was identified using solvent extraction experiments. The obtained complex formation constant of PaO(OH)(EDTA)2− was large, and the Pa(V)–EDTA complex was stable.

2-Methacryloyloxyethyleniminodiacetic acid and its new water-soluble copolymers with N-vinylpyrrolidone have been synthesized. The interaction of the copolymers in dilute aqueous solutions with lanthanide ions has been studied. The study has revealed the 25-fold amplification of Eu3+ luminescence in the polymer complex has been revealed as compared with a low-molecular-weight analog upon the formation of both heteroligand complexes with thenoyltrifluoroacetone and Eu3+ and Gd3+ heterometallic (bimetallic) complexes.

The precise control of phosphors with well-defined features remains a challenging issue since its property has been closely related to the shape, surface modification and particle size. The studies to develop microstructure under mild conditions will be of general interests. Herein, 2-thenoyltrifluoroacetone (TTA) has been incorporated as a viable technique to bind with surface of BaMgF4:Eu3+ phosphor and such process has been proved to be an effective strategy in preparing inorganic materials. The well acceptable advantages of this way include facile synthesis steps, broaden excitation range and reduced particle size. Although lanthanide fluorides have been reported so far, there are limited studies concerning organic framework appended red phosphors. In this way, the exploitation of a simple method to assemble hybrid phosphors will be very valuable in opto-electronic industries.

The current works extend the utility of 2-thenoyltrifluoroacetone reagent (HTTA) towards the least explored antimony (III & V) ions in complex matrices. The redox characteristics and the excellent surface coverage (Γ) of the electroactive antimony (III)-HTTA chelate onto the hanging mercury dropping electrode suggested establishing a differential pulse cathodic stripping voltammetric (DP–CSV) analysis for chemical speciation of antimony (III & V) in environmental water samples. Under the optimized conditions of pH, deposition time, potential, sweep rate, and HTTA concentration, the cathodic peak current at − 0.18 V linearly increased on growing antimony (III) concentration in a wide working range from 2.46 × 10−9 to 1.07 × 10−7 mol L−1, with an obtained detection and quantification limits 7.38 × 10−10 and 2.46 × 10−9 mol L−1, respectively. The figure of merits were compared successfully with some reported electrochemical, chromatographic, and spectrochemical methods. The established DP–CSV method has a unique advantages (rapid response, short analytical time, sensitive, selective, and reproducible) to be quantitatively applied for trace analysis of antimony (III & V) species in fresh and marine water (the Atlantic Ocean and the Red Sea) samples. The settled method was also validated (Student’s t and F tests at P = 0.05) by comparison with the official inductively coupled plasma-mass spectrometry (ICP-MS) method.

The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine that venetoclax-sensitive myeloma has reduced mitochondrial respiration. Consistent with this, low electron transport chain (ETC) Complex I and Complex II activities correlate with venetoclax sensitivity. Inhibition of Complex I, using IACS-010759, an orally bioavailable Complex I inhibitor in clinical trials, as well as succinate ubiquinone reductase (SQR) activity of Complex II, using thenoyltrifluoroacetone (TTFA) or introduction of SDHC R72C mutant, independently sensitize resistant MM to venetoclax. We demonstrate that ETC inhibition increases BCL-2 dependence and the ‘primed’ state via the ATF4-BIM/NOXA axis. Further, SQR activity correlates with venetoclax sensitivity in patient samples irrespective of t(11;14) status. Use of SQR activity in a functional-biomarker informed manner may better select for MM patients responsive to venetoclax therapy., Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with IACS-010759 or CII with TTFA increase sensitivity.

Water-soluble polymeric complexones, N-vinylpyrrolidone-N-allyl-p-aminosalicylic acid copolymers with low content of chelating units, were synthesized. The formation of Eu3+ heteroligand complexes containing these complexones was studied. The complexation of Eu3+ with the polymeric complexone and low-molecular-mass organic coligand, thenoyltrifluoroacetone (TTA), ensures efficient energy transfer from molecular orbitals of the polymeric ligand to Eu3+, allowing the Eu3+ luminescence intensity in aqueous solutions to be enhanced by more than 1–1.5 orders of magnitude. The maximal intensity of the Eu3+ luminescence in the heteroligand complex is observed at the [Eu3+]:[COO−] ratio of ∼1 and [Eu3+]/[TTA] = 1.2−1.5. In the presence of univalent metal salts, the Eu3+ luminescence intensity does not noticeably change up to their concentration of 0.4 M. Addition of Ca2+ or Mg2+ salts leads to a drastic decrease in the Eu3+ luminescence intensity in the solution.

This paper first reports on the high-selective separation and recovery of Li(I) from Na(I) and K(I) using the polymer inclusion membrane (PIM) system containing both thenoyltrifluoroacetone (TTA) and trioctylphosphine oxide (TOPO) as the carrier molecules, and cellulose triacetate (CTA) as the base polymer. To characterize the PIM, we used Fourier Transform infrared (FT-IR) spectroscopy, scanning election microscopy (SEM) and thermogravimetric analysis (TGA). The optimized results of this work showed that initial flux ( J 0 ) of Li(I) that was as high as 1.04 × 10−2 mol m−2 h−1, corresponding to permeability ( P ) of 3.62 × 10−3 m h−1, were recorded using the PIM composed of 50 wt% CTA and 26.74 wt% TTA + 23.26 wt% TOPO from a feed phase containing Li(I), Na(I) and K(I) in an alkaline chloride solution into an acceptor phase containing 0.1 M HCl. Li(I) was transported successfully to the acceptor phase but Na(I) and K(I) barely passed in the first 20 h. The separation factor ( S F ) of Li(I) over the Na(I) and K(I) respectively ( S F L i ( I ) / N a ( I ) ≒ 54.25, S F L i ( I ) / k ( I ) ≒ 50.60) demonstrated that Li(I) can be high-selectively separated. It is expected that this membrane can be applied for selective recovery of Li(I) from salt lakes or sea water that contains significant concentrations of Na(I) and K(I).

The calculation of defects in the structures of the Sc, La, Nd, Sm, Tb, and Yb complexes with substituted phenolate and naphtholate ligands formed under the action of neutrons with a mean energy of 2 MeV shows that the shifts of the target atoms depend on their masses and can achieve 1 μm for O, N, and S. A similar result is obtained for the calculation of the destruction of the Eu(TTA)3(DME)2 complex (HTTA is thenoyltrifluoroacetone). However, the treatment of the samples with the n,γ radiation does not result in destruction. Possible reasons for the found divergence between the calculated and experimental data are discussed.

The acid–base properties, protonation activity, and complexing abilities of two substituted β-diketones have been studied. The equilibrium constants of dissociation (pKa) were obtained at constant ...

Lithium extraction from ammoniacal solution with thenoyltrifluoroacetone (HTTA) and neutral ligand was studied in various organic solvents. The remarkable enhancement of lithium extraction was observed by the addition of neutral organophosphorus compounds and the experiments showed that trioctylphosphine oxide(TOPO) was preferable for lithium extraction. The synergistic effect of thenoyltrifluoroacetone and trioctylphosphine was studied in detail and the results indicated that the strongest enhancement coefficient was 1205 when molar ratio of two extractants was 1:1. The extracted lithium complex was found to be Li•TTA•2TOPO by slope method and the results of thermodynamic study indicated that the extraction process was spontaneous exothermic process and the degree of disorder increased after extraction. In addition, stripping and regeneration condition of organic phase were investigated in detail. It was demonstrated that the synergistic extraction system containing HTTA and TOPO could effectively separate lithium and other alkali metal ions and was feasible for lithium extraction from ammoniacal solution.

The complexation of 2-thenoyltrifluoroacetone (HTTA) with trivalent lanthanides was studied in a room temperature ionic liquid, viz. 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (C4mim·Tf2N) by liquid–liquid extraction, absorption spectroscopy and time-resolved fluorescence spectroscopy. The metal ion distribution data indicated the extraction of anionic species of the type Ln(TTA)4−, where the charge balance of the C4mim·Tf2N phase is maintained by the transfer of one Tf2N− anion into the aqueous phase. Spectrophotometric titration of Nd3+ with HTTA indicated that the latter existed predominantly as the keto form in C4mim·Tf2N and did not form a complex with the metal ion. On the other hand, it formed complexes when TTA− salt was used where it predominantly existed in the enol form. Titration of Nd3+ with TTA− confirmed the formation of Nd(TTA)2+, Nd(TTA)2+, Nd(TTA)3° and Nd(TTA)4− species with the stability constant (log β) values of 5.82, 10.6, 14.5 and 17.8, respectively. Fluorescence measurements confirmed that the fully hydrated aqua Eu3+ cation in C4mim·Tf2N was completely dehydrated upon complexation with TTA−. Based on spectroscopic evidence, it was deduced that TTA− formed an 8 coordinated [Eu·(TTA)4]− anionic complex in C4mim·Tf2N.

The solvent extraction of Eu(III) from an aqueous chloride phase into hydrophobic ionic liquids (ILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imides ([C1Cnim+][Tf2N−], n = 4, 6, 8 and 10), by β-diketone 2-thenoyltrifluoroacetone (HTTA) alone and in combination with N,N-diisobutyl-2-(octylphenylphosphoryl)acetamide (CMPO) was investigated. The interaction between the two extractants (acidic/neutral) in deuterochloroform has been studied by 1H, 13C, 19F and 31P NMR spectra and NOESY experiments. 1H and 19F Q-NMR analytical techniques were also applied for determination of [C1C4im+] and [Tf2N−] entities transferred into the aqueous phase. Eu(III) was efficiently extracted by HTTA/[C1Cnim+][Tf2N−] and HTTA/CMPO/[C1Cnim+][Tf2N−] systems but a relatively small synergism was established. A cation extraction mechanism was proposed via the log–log slope analysis method. The effect of the IL cation alkyl chain length on the extraction process was studied as well.

Made available in DSpace on 2021-06-25T10:30:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-26 The effects of respiratory inhibitors, quinone analogues and artificial substrates on the membrane-bound electron transport system of the fastidious β-proteobacterium Eikenella corrodens grown under O2-limited conditions were studied. NADH respiration in isolated membrane particles were partially inhibited by rotenone, dicoumarol, quinacrine, flavone, and capsaicin. A similar response was obtained when succinate oxidation was performed in the presence of thenoyltrifluoroacetone and N,N'-dicyclohexylcarbodiimide. NADH respiration was resistant to site II inhibitors and cyanide, indicating that a percentage of the electrons transported can reach O2 without the bc1 complex. Succinate respiration was sensitive to myxothiazol, antimycin A and 2-heptyl-4-hydroxyquinoline-N-oxide (HQNO). Juglone, plumbagin and menadione had higher reactivity with NADH dehydrogenase. The membrane particles showed the highest oxidase activities with ascorbate-TCHQ (tetrachlorohydroquinone), TCHQ alone, and NADH-TMPD (N,N,N',N'-tetramethyl-p-phenylenediamine), and minor activity levels with ascorbate-DCPIP (2,6-dichloro-phenolindophenol) and NADH-DCPIP. The substrates NADH-DCPIP, NADH-TMPD and TCHQ were electron donors to cyanide-sensitive cbb' cytochrome c oxidase. The presence of dissimilatory nitrate reductase in the aerobic respiratory system of E. corrodens ATCC 23834 was demonstrated by first time. Our results indicate that complexes I and II have resistance to their classic inhibitors, that the oxidation of NADH is stimulated by juglone, plumbagin and menadione, and that sensitivity to KCN is stimulated by the substrates TCHQ, NADH-DCPIP and NADH-TMPD. Grupo de Investigación de Biomembranas (GIBIOM) Facultad Ciencias de La Salud Centro Seccional de Investigación (CIUL), Universidad Libre Campus Barranquilla Grupo de Micología Departamento de Microbiología Facultad de Medicina Universidad de Cartagena Campus Zaragocilla School of Agricultural and Veterinary Sciences Technology Department São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n School of Agricultural and Veterinary Sciences Technology Department São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n

Synthesis and characterization of chromium(III) complexes with 2-thenoyltrifluoroacetone ligand are described and the crystal structures of the two possible geometric isomers, efficiently obtained by crystallization, are reported for the first time. In the solid state structure, both isomers reveal a distorted octahedral geometry of the metal ion. In addition, absorption and emission properties of the complex are determined in solution and in a polymethylmethacrylate (PMMA) matrix.

Four Schiff bases, derived from 2-thenoyltrifluoroacetone with methyl amine, ethyl amine, propyl amine and phenyl amine and their thione derivatives have been synthesized. The compounds were characterized by melting point, IR, NMR and microanalysis. Analysis of the IR and NMR spectra indicates that the condensation occurs at the carbonyl group adjacent to the CF3 moiety. Furthermore, the product exists mainly in the keto amine form. Subsequent-thiolation of each Schiff bases occurs at the carbonyl adjacent to the thiophene ring and the product has the thione amine. The present study has shown that the structures of the synthesized compounds are as follows

A series of EuIII complexes with thenoyltrifluoroacetone (tta) as the ligands were synthesized, which are balanced with imidazolium cations bearing naphthyl and branched alkyl chains. The complex with the longest alkyl chain (1Eu(tta)4 ) shows aggregation behavior in ethanol and water mixtures. It exists as individuals at low water percentages (VH2O ), and form particles with solid interiors at VH2O ≥50 % the sizes of which decrease with the increase of VH2O . At VH2O =90 %, vesicles were observed. The aggregation of 1Eu(tta)4 in ethanol and water binary mixtures induced changes of the photoluminescence (PL) properties where an abrupt increase in PL intensity, quantum yield, and lifetime were noticed above VH2O =50 %. This PL enhancement can be explained by the encapsulation of 1Eu(tta)4 inside the aggregates, preventing it from quenching by the active hydroxyls of water molecules. Contrary to the aggregation-induced emission (AIE) of the Eu complex, the naphthyl group in the imidazolium cation exhibited an aggregation-caused quenching (ACQ) effect. When the length of the alkyl chain in the imidazolium cation is reduced, no PL enhancement can be observed owing to the difficulty in forming the aggregates.

The objectives of this study were to develop a robust protocol for measuring the rate of hydrogen peroxide (H(2)O(2)) production in isolated perfused rat lungs, as an index of oxidative stress, and to determine cellular sources of the measured H(2)O(2) using the extracellular probe Amplex red (AR). AR was added to recirculating perfusate in an isolated perfused rat lung. AR’s highly fluorescent oxidation product resorufin was measured in the perfusate. Experiments were carried without and with rotenone (complex I inhibitor), thenoyltrifluoroacetone (complex II inhibitor), antimycin A (complex III inhibitor), potassium cyanide (complex IV inhibitor), or diohenylene iodonium (inhibitor of flavin-containing enzymes, e.g. NAD(P)H oxidase or NOX) added to the perfusate. We also evaluated the effect of acute changes in oxygen (O(2)) concentration of ventilation gas on lung rate of H(2)O(2) release into the perfusate. Baseline lung rate of H(2)O(2) release was 8.45 ± 0.31 (SEM) nmol/min/g dry wt. Inhibiting mitochondrial complex II reduced this rate by 76%, and inhibiting flavin-containing enzymes reduced it by another 23%. Inhibiting complex I had a small (13%) effect on the rate, whereas inhibiting complex III had no effect. Inhibiting complex IV increased this rate by 310%. Increasing %O(2) in the ventilation gas mixture from 15% to 95% had a small (27%) effect on this rate, and this O(2)-dependent increase was mostly non-mitochondrial. Results suggest complex II as a potentially important source and/or regulator of mitochondrial H(2)O(2), and that most of acute hyperoxia-enhanced lung rate of H(2)O(2) release is from non-mitochondrial rather than mitochondrial sources.

The luminescent dye Europium III (thenoyltrifluoroacetone)(4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine) (Eu III (TTFA) 3 (MePhTerpy)) has been proposed as a probe molecule for a fast photocatalytic test of TiO 2 -materials. For an industrial application of this test method the underlying photocatalytic reaction mechanism and the degradation products of the dye need to be known. Hence, in this study the adsorption and the photocatalytic degradation of the luminescent dye on the TiO 2 surface were investigated by means of ATR-FTIR spectroscopy and GC/MS analysis. The dye is adsorbed by the thenoyltrifluoroacetone (TTFA) ligand on the TiO 2 surface as evinced by the respective ATR-FTIR spectra. It is assumed that TTFA and TiO 2 form hydrogen bonds. Upon UV illumination the ATR-FTIR spectra reveal a degradation of the TTFA ligand forming trifluoroacetic acid (TFAA) and 2-thiophenecarboxylic acid (TCA). GC/MS analysis confirms the ATR-FTIR results because TCA and TFAA are also detected here. Additionally, 2-thiophenecarboxaldehyde is observed, which is proposed to be an intermediate that is further oxidized to TCA.

Thenoyltrifluoroacetone (HTTA)-based extractions represent popular methods for separating microscopic amounts of transuranic actinides (i.e., Np and Pu) from macroscopic actinide matrixes (e.g. bulk uranium). It is well-established that this procedure enables +4 actinides to be selectively removed from +3, + 5, and +6 f-elements. However, even highly skilled and well-trained researchers find this process complicated and (at times) unpredictable. It is difficult to improve the HTTA extraction—or find alternatives—because little is understood about why this separation works. Even the identities of the extracted species are unknown. In addressing this knowledge gap, we report here advances in fundamental understanding of the HTTA-based extraction. This effort included comparatively evaluating HTTA complexation with +4 and +3 metals (MIV = Zr, Hf, Ce, Th, U, Np, and Pu vs MIII = Ce, Nd, Sm, and Yb). We observed +4 metals formed neutral complexes of the general formula MIV(TTA)4. Meanwhile, +3 metals formed an...

2-Thenoyltrifluoroacetone has been offered as a mobile carrier in organic phase for the transport and selective separation of yttrium from aqueous media using a liquid membrane system. Perceivably, the use of n-propylamine (PA) in the source phase enhances the transport of yttrium ions. The extraction and stripping conditions have entirely been evaluated and explained. The suggested method has been utilized for the separation of yttrium(III) from its binary mixtures with strontium(II) and some other cations such as Ni2+, Co2+, Ag+, Fe2+, Al3+, Cu2+, Hg2+and Cs+ in aqueous solutions of pH 5.4 in the presence of PA, while 1 M nitric acid was acting as a stripping agent in the receiving division. Cyanide ion and 5-sulfosalicylic acid have been used as masking agents to minimize the interferences from different transition metal ions and Al3+ in the source phase, respectively. 90Y in secular equilibrium with 90Sr in the source phase, was transferred to receiving phase and separated completely from its long-lived parent isotope. The activity of the transported 90Y was found to decay with a half-life 64.17 ± 0.05 h. The purity of yttrium-90 was comparable or better than the other applied liquid membrane systems for purification of yttrium-90.

A substituted pyridazine was used to construct a family of mononuclear heteroleptic complexes [Ln(tta)3(dppn)], Ln = Pr–Lu; Htta = thenoyltrifluoroacetone; dppn = 3,6-di(2-pyridyl)pyridazine. All the complexes obtained were characterized by CHN elemental analysis, NMR spectroscopy, ESI mass spectrometry, FTIR spectroscopy and single crystal X-ray analysis. The photophysical properties of lanthanide complexes were carefully investigated, and the dppn ligand was found to act as a chromophore centre to sensitize metal-centred emission of the Nd, Sm, Eu, and Yb complexes under UV excitation. It has been shown that a powder sample of the Eu complex can contain two isomers with somewhat different symmetries of the environment of the metallocentre. The mechanism for the emission of luminescent Nd, Sm, Eu, and Yb complexes was investigated by TDDFT calculations and the results confirmed the conclusion made on the basis of experimental data regarding the likely pathway of energy transfer from the chromophore centre to the emissive level of Ln(III).

In the last years the development of new luminescent materials was grow highly in order to find efficient materials with low cost of processing. In this way the organic luminescent materials have special attention because its special characteristics, like antenna effect, low temperature processing, possibility to make translation to polymeric and flexible compounds. In this work luminescent powders of TTA:Eu3+ by sol-gel method were synthesized in order to define the synthesis parameters of the highest luminescence. The temperatures of heat treatment were 80°C, 100°C, 200°C and the concentration of Europium where 10%, 20%, 30% and 40% mol (TTA-10Eu, TTA-20Eu, TTA-30Eu, and TTA-40Eu). Fourier Transform Infrared Rays analysis (FTIR) and emission luminescence measures, the best conditions of synthesis were obtained at 40% mol of Europium and 80°C of heat treatment, at 272 nm of excitation. All the samples present the corresponded Eu3+ ion transitions the 5D0 → 7FJ (J = 0, 1, and 2). This confirms the great possibilities of these materials for optoelectronic applications.

Two novel mononuclear complexes, [Zn (TTA) (bipy)Cl] (1) and [Zn (TTA) (phen)Cl] (2) (TTA = 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione, phen = 1,10-phenanthroline and bipy 2, 2ʹ-bipyridine), were synthesized and fully characterized by elemental analyses, 1H NMR, UV–Vis, FTIR spectroscopy, and conductivity measurements. The crystal structures of these two mono-nuclear zinc (II) complexes were determined by X-ray single-crystal diffraction. The result of X-ray diffraction analyses revealed that both complexes have distorted tetragonal-pyramid structures. In MTT cytotoxicity studies, these Zn (II) complexes exhibited antitumor activity against MCF-7 and MKN-45 cell lines. It was also found that the proliferation rate of MCF-7 and MKN-45 cells decreased after treatment with the above-mentioned complexes. In addition, the apoptosis-inducing activity was assessed by AO/EB (Acridine Orange/Ethidium bromide) staining assay and found that they have the potential to act as effective metal-based anticancer drugs. Finally, the molecular docking studies showed that complex 2 strongly binds through minor groove with DNA by relative binding energy −7.33 kcal mol−1.

Five complexes [Mn(ttfa)2(py)2] (1), [Co(ttfa)3] (2), [Ni(ttfa)2(en)] (3), [Cd(ttfa)2(bpy)] (4), and [Cu(ttfa)2(py)] (5) {where Httfa=2-thenoyltrifluoroacetone} have been synthesized and characterized by elemental analyses, IR, UV-Vis and single crystal X-ray diffraction data. Both oxygen atoms of ttfa chelate with the metal ions forming six-membered C3O2M chelate rings in the complexes. In complexes 1–4 the metal ion adopts a distorted octahedral geometry while the complex 5 is distorted square pyramidal. In the solid state, complexes are stabilized by various types of inter-intramolecular interactions. Upon excitation at about 29500 cm−1, complexes 1, 2, 3 and 5 exhibit blue emissions while the complex 4 emits violet colour. Electrochemical studies of Httfa and complexes show irreversible redox behavior. Thermal degradation of the complexes as analyzed by TG-DTA suggests the formation of their respective metal oxides as final thermally stable chemical entities. Httfa, complex 1 and 5 are studied for cytotoxicity on Dalton's lymphoma cells using MTT assay, apoptotic analysis and DNA fragmentation assay which reveals their order of activity as complex 5 > complex 1 > Httfa.

Three Cd(II) complexes, [Cd(5-thot)2(en)2] (1), [Cd(thd)2(µ-Br)]n (2) and [Cd(ttfa)2(en)] (3) have been synthesized from 5-(thiophen-2-yl)-1,3,4-oxadiazole-2-thione, 2-thiohydantoin and 2-thenoyltrifluoroacetone by the reaction of cadmium(II) salt. The complexes have been characterized by various physicochemical methods. Complexes 1, 2 and 3 crystallize in monoclinic system with space group P21/n, P21/c and P21/c, respectively. The Cd(II) center in complex 1 adopts a distorted octahedral geometry with two oxadiazole nitrogen and four nitrogen atoms of two en ligands. In the polymeric structure of complex 2, the Cd(II) center is bonded through two thione sulphur and four bridged bromide ions having distorted octahedral geometry. The Cd(II) ion is bonded through two ethylenediamine nitrogens and four thenoyl oxygen atoms in complex 3. The course of the thermal degradations of complexes 1–3 have been investigated by TGA which indicate that metal oxide is formed as the final residue. The complexes are stabilized by various types of intermolecular extended hydrogen bonding providing supramolecular framework.

In this study, the removal of uranium from aqueous solution is studied using emulsion liquid membrane (ELM) system. The ELM is made up of 2-Thenoyltrifluoroacetone (HTTA) as a carrier, kerosene as an organic diluent, HCl as a stripping solution and sorbitan monooleate (Span-80) as a surfactant for stabilizing the emulsion phase. Initially, the important parameters affecting the removal of uranium, were screened out using a fractional factorial design. Then the effect of the selected factors were studied to obtain the optimal conditions. Under the assessed conditions (pH of donor phase = 5; HTTA concentration in the membrane phase = 0.02 mol/L; emulsion/donor phase volume ratio = 0.2; uranium concentration in the donor phase

We report here the fast synthesis by microwave assisted technique of four ternary Ln(TTA)3(TPPO)2 complexes, where Ln = La(III), Eu(III), Tb(III) and Tm(III), TTA = 2-thenoyltrifluoroacetone, and TPPO = triphenylphosphine oxide, which are of interest in luminescence applications. Using this method, the reaction time was decreased to one minute with minimal purification step and the yields are comparable to literature values. The target complexes were characterized using 1H, 13C, 19F, 31P NMR and FTIR spectroscopy, MALDI-TOF mass spectrometry and single-crystal X-ray diffraction. Further, we discuss here a hitherto unreported extensive network of hydrogen bonding interactions present in these complexes.

Triclosan (5-chloro-2'-(2,4-dichlorophenoxy)phenol), a widely used antibacterial agent, exerts adverse effects on the organism of mammals. Recent research reviled that triclosan at low micromolar concentrations causes mitochondrial dysfunction in many cell types, but the mechanisms of its effect are not fully understood. Here we show that exposure to triclosan disrupted membrane potential, prevented the calcium uptake-driven high-amplitude mitochondrial swelling, stimulated the respiration in the presence of complex I substrates, and suppressed the ADP-stimulated respiration in the presence of complex II substrate, succinate. Triclosan directly inhibited complex II activity. Similar to the complex II inhibitor thenoyltrifluoroacetone, triclosan induced the oxidation of the cytochromes b566 and b562 and caused the release of mitochondrial superoxide. Opposite to thenoyltrifluoroacetone, triclosan increased superoxide release synergistically with myxothiazol but not with antimycin A, indicating different topology of superoxide-producing sites. We concluded that triclosan is unique by its capability of acting as both a protonophore and an unusual complex II inhibitor, which interferes with the mitochondrial respiration by blocking the electron transfer between ubiquinone at the Qd-binding site and heme b. Our data can provide an insight into the mechanisms of the carcinogenic effect of triclosan in the liver and other tissues.