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1. National workflow experience with pulsed field ablation for atrial fibrillation: learning curve, efficiency, and safety

Author

Bisignani, Antonio, Schiavone, Marco, Solimene, Francesco, Dello Russo, Antonio, Filannino, Pasquale, Magnocavallo, Michele, Tondo, Claudio, Schillaci, Vincenzo, Casella, Michela, Petretta, Andrea, Rossi, Pietro, Fassini, Gaetano, Rossillo, Antonio, Maggio, Ruggero, Themistoclakis, Sakis, Pandozi, Claudio, Polselli, Marco, Tundo, Fabrizio, Arestia, Alberto, Compagnucci, Paolo, Valente Perrone, Annelisa, Malacrida, Maurizio, Iacopino, Saverio, and Bianchi, Stefano

Published
2024
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2. Intracardiac echocardiography–guided pulsed-field ablation for successful ablation of atrial fibrillation: a propensity-matched analysis from a large nationwide multicenter experience

Author

Dello Russo, Antonio, Tondo, Claudio, Schillaci, Vincenzo, Casella, Michela, Iacopino, Saverio, Bianchi, Stefano, Fassini, Gaetano, Rossillo, Antonio, Compagnucci, Paolo, Schiavone, Marco, Salito, Armando, Maggio, Ruggero, Cipolletta, Laura, Themistoclakis, Sakis, Pandozi, Claudio, Filannino, Pasquale, Rossi, Pietro, Bonanno, Carlo, Parisi, Quintino, Malacrida, Maurizio, and Solimene, Francesco

Published
2024
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3. Safety and efficacy of a light antithrombotic regimen after left atrial appendage occlusion: Insights from the LOGIC (left atrial appendage occlusion in patients with gastrointestinal or IntraCranial bleeding) international multicenter registry

Author

Gallo, Francesco, D'Addazio, Matteo, D'Amico, Gianpiero, Della Rocca, Domenico G., Mazzone, Patrizio, Bordignon, Stefano, Casu, Gavino, Giannini, Francesco, Berti, Sergio, Horton, Rodney P., D'Angelo, Giuseppe, Urbanek, Lukas, Merella, Pierluigi, Ruggiero, Rossella, Bosica, Francesco, Schmidt, Boris, Atzori, Enrico, Barbierato, Marco, Natale, Andrea, Themistoclakis, Sakis, and Ronco, Federico

Published
2025
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6. Atrial High-Rate Episodes and Subclinical Atrial Fibrillation: State of the Art and Clinical Questions with Complex Solutions.

Author

Brookles, Carola Griffith, De Ponti, Roberto, Russo, Vincenzo, Ziacchi, Matteo, Pelargonio, Gemma, Casella, Michela, Lauretti, Maurelio, Vilotta, Manola, Themistoclakis, Sakis, D’Onofrio, Antonio, Boriani, Giuseppe, and Anselmino, Matteo

Abstract

Atrial high-rate episodes (AHREs) and subclinical atrial fibrillation (AF) are frequently registered in asymptomatic patients with cardiac implantable electronic devices (CIEDs) and insertable cardiac monitors (ICMs). While an increased risk of thromboembolic events (e.g., stroke) and benefits from anticoagulation have been widely assessed in the setting of clinical AF, concerns persist about optimal clinical management of subclinical AF/AHREs. As a matter of fact, an optimal threshold of subclinical episodes’ duration to predict stroke risk is still lacking and recently published randomized clinical trials assessing the impact of anticoagulation on thromboembolic events in this specific setting have shown contrasting results. The aim of this review is to summarize current evidence regarding classification and clinical impact of subclinical AF/AHREs and to discuss the latest evidence regarding the potential benefit of anticoagulation in this setting, highlighting which clinical questions are still unanswered. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Urgent Pacemaker Implantation Rates in the Veneto Region of Italy after the COVID-19 Outbreak

Author

Migliore, Federico, Zorzi, Alessandro, Gregori, Dario, Del Monte, Alvise, Falzone, Pasquale Valerio, Verlato, Roberto, Siciliano, Mariachiara, Themistoclakis, Sakis, China, Paolo, Marchese, Domenico, Pasquetto, Giampaolo, Ignatiuk, Barbara, Cernetti, Carlo, Giacomin, Enrico, Calzolari, Vittorio, Bilato, Claudio, Valle, Chiara Dalla, Frigo, Gianfranco Mario, Marinaccio, Leonardo, Saccà, Salvatore, Lupo, Antonio, Roncon, Loris, Marcantoni, Lina, Tosi, Alberto, Turiano, Giovanni, Folino, Franco, Marra, Martina Perazzolo, Cacciavillani, Luisa, and Iliceto, Sabino

Published
2020
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10. Detection of brain lesions after catheter ablation depends on imaging criteria – Insights from AXAFA-AFNET 5 trial

Author

Haeusler, Karl Georg, primary, Eichner, Felizitas A, additional, Heuschmann, Peter U, additional, Fiebach, Jochen B, additional, Engelhorn, Tobias, additional, Callans, David, additional, De Potter, Tom, additional, Debruyne, Philippe, additional, Scherr, Daniel, additional, Hindricks, Gerhard, additional, Al-Khalidi, Hussein R, additional, Mont, Lluis, additional, Kim, Won Yong, additional, Piccini, Jonathan P, additional, Schotten, Ulrich, additional, Themistoclakis, Sakis, additional, Di Biase, Luigi, additional, and Kirchhof, Paulus, additional

Published
2023
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11. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian-Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S. S. G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024
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13. Real-practice thromboprophylaxis in atrial fibrillation

Author

Deambrosis Paola, Bettiol Alessandra, Bolcato Jenny, Pirolo Roberta, Franchin Giulia, Themistoclakis Sakis, Pellizzari Michele, Chinellato Alessandro, and Giusti Pietro

Subjects
atrial fibrillation, thromboprophylaxis, realpractice, vitamin k antagonists, stroke risk, Pharmaceutical industry, HD9665-9675
Abstract

This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received vitamin K antagonist (VKA). Potential barriers decreasing the probability of being treated with VKA were female sex, older age, antiplatelet treatment and history of bleeding. In addition, VKA-treatment was not in line with current ESC and AIAC guidelines, since the patients at high or low risk of stroke were under- or over-treated, resp. Among VKAtreated patients, 73 % of subjects were not at target with anticoagulation. OAT resulted to be effective in reducing stroke risk. However, stroke events were significantly influenced also by previous stroke or transient ischemic attack (hazard ratio, HR = 2.99, p < 0.001) and by previous bleeding events (HR = 1.60, p < 0.001).

Published
2017
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15. Proven isolation of the pulmonary vein antrum with or without left atrial posterior wall isolation in patients with persistent atrial fibrillation

Author

Bai, Rong, Di Biase, Luigi, Mohanty, Prasant, Trivedi, Chintan, Dello Russo, Antonio, Themistoclakis, Sakis, Casella, Michela, Santarelli, Pietro, Fassini, Gaetano, Santangeli, Pasquale, Mohanty, Sanghamitra, Rossillo, Antonio, Pelargonio, Gemma, Horton, Rodney, Sanchez, Javier, Gallinghouse, Joseph, Burkhardt, J. David, Ma, Chang-Sheng, Tondo, Claudio, and Natale, Andrea

Published
2016
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16. Stereotactic Arrhythmia Radioablation Treatment of Ventricular Tachycardia: Current Technology and Evolving Indications

Author

Guarracini, Fabrizio, primary, Tritto, Massimo, additional, Di Monaco, Antonio, additional, Mariani, Marco Valerio, additional, Gasperetti, Alessio, additional, Compagnucci, Paolo, additional, Muser, Daniele, additional, Preda, Alberto, additional, Mazzone, Patrizio, additional, Themistoclakis, Sakis, additional, and Carbucicchio, Corrado, additional

Published
2023
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17. Effect of periprocedural amiodarone on procedure outcome in patients with longstanding persistent atrial fibrillation undergoing extended pulmonary vein antrum isolation: Results from a randomized study (SPECULATE)

Author

Mohanty, Sanghamitra, Di Biase, Luigi, Mohanty, Prasant, Trivedi, Chintan, Santangeli, Pasquale, Bai, Rong, Burkhardt, John David, Gallinghouse, Joseph G., Horton, Rodney, Sanchez, Javier E., Hranitzky, Patrick M., Zagrodzky, Jason, Al-Ahmad, Amin, Pelargonio, Gemma, Lakkireddy, Dhanunjay, Reddy, Madhu, Forleo, Giovanni, Rossillo, Antonio, Themistoclakis, Sakis, Hongo, Richard, Beheiry, Salzwa, Casella, Michela, Dello Russo, Antonio, Tondo, Claudio, and Natale, Andrea

Published
2015
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18. Case 48

Author

Rossillo, Antonio, Themistoclakis, Sakis, Bonso, Aldo, Corrado, Andrea, Raviele, Antonio, Natale, Andrea, editor, Al-Ahmad, Amin, editor, Wang, Paul J., editor, and DiMarco, John, editor

Published
2011
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19. Case 22

Author

Rossillo, Antonio, Themistoclakis, Sakis, Bonso, Aldo, Corrado, Andrea, Raviele, Antonio, Natale, Andrea, editor, Al-Ahmad, Amin, editor, Wang, Paul J., editor, and DiMarco, John, editor

Published
2011
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20. Case 18

Author

Rossillo, Antonio, Themistoclakis, Sakis, Bonso, Aldo, Corrado, Andrea, Raviele, Antonio, Natale, Andrea, editor, Al-Ahmad, Amin, editor, Wang, Paul J., editor, and DiMarco, John, editor

Published
2011
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21. Therapeutic vs. prophylactic anticoagulation in COVID-19 patients: a systematic review and meta-analysis of real-world studies

Author

VIO, Riccardo, primary, GIORDANI, Andrea S., additional, STEFIL, Maria, additional, ALTURKI, Ahmed, additional, RUSSO, Vincenzo, additional, CHINA, Paolo, additional, GASPERETTI, Alessio, additional, SCHIAVONE, Marco, additional, ČULIĆ, Viktor, additional, BIONDI-ZOCCAI, Giuseppe, additional, THEMISTOCLAKIS, Sakis, additional, YH LIP, Gregory, additional, and PROIETTI, Riccardo, additional

Published
2023
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22. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference

Author

Kotecha, Dipak, Breithardt, Günter, Camm, A John, Lip, Gregory Y H, Schotten, Ulrich, Ahlsson, Anders, Arnar, David, Atar, Dan, Auricchio, Angelo, Bax, Jeroen, Benussi, Stefano, Blomstrom-Lundqvist, Carina, Borggrefe, Martin, Boriani, Giuseppe, Brandes, Axel, Calkins, Hugh, Casadei, Barbara, Castellá, Manuel, Chua, Winnie, Crijns, Harry, Dobrev, Dobromir, Fabritz, Larissa, Feuring, Martin, Freedman, Ben, Gerth, Andrea, Goette, Andreas, Guasch, Eduard, Haase, Doreen, Hatem, Stephane, Haeusler, Karl Georg, Heidbuchel, Hein, Hendriks, Jeroen, Hunter, Craig, Kääb, Stefan, Kespohl, Stefanie, Landmesser, Ulf, Lane, Deirdre A, Lewalter, Thorsten, Mont, Lluís, Nabauer, Michael, Nielsen, Jens C, Oeff, Michael, Oldgren, Jonas, Oto, Ali, Pison, Laurent, Potpara, Tatjana, Ravens, Ursula, Richard-Lordereau, Isabelle, Rienstra, Michiel, Savelieva, Irina, Schnabel, Renate, Sinner, Moritz F, Sommer, Philipp, Themistoclakis, Sakis, Van Gelder, Isabelle C, Vardas, Panagiotis E, Verma, Atul, Wakili, Reza, Weber, Evelyn, Werring, David, Willems, Stephan, Ziegler, André, Hindricks, Gerhard, and Kirchhof, Paulus

Published
2018
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23. Takotsubo Syndrome during COVID-19 Pandemic in the Veneto Region, Italy

Author

Zuin, Marco, primary, Mugnai, Giacomo, additional, Anselmi, Maurizio, additional, Bonapace, Stefano, additional, Bozzini, Paolo, additional, Chirillo, Fabio, additional, Cutolo, Ada, additional, Grassi, Giuseppe, additional, Mancuso, Daniela, additional, Meneghin, Samuele, additional, Molon, Giulio, additional, Mugnolo, Antonio, additional, Pantano, Ivan, additional, Polo, Angela, additional, Purita, Paola, additional, Roncon, Loris, additional, Saccà, Salvatore, additional, Scarpa, Daniele, additional, Tavella, Domenico, additional, Themistoclakis, Sakis, additional, Turiano, Giovanni, additional, Valle, Roberto, additional, Widmann, Maddalena, additional, Zakja, Edlira, additional, Zamboni, Alberto, additional, Rigatelli, Gianluca, additional, and Bilato, Claudio, additional

Published
2022
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24. Decline of Admission for Acute Coronary Syndromes and Acute Cardiovascular Conditions during COVID-19 Pandemic in Veneto Region

Author

Zuin, Marco, primary, Mugnai, Giacomo, additional, Zamboni, Alberto, additional, Zakja, Edlira, additional, Valle, Roberto, additional, Turiano, Giovanni, additional, Themistoclakis, Sakis, additional, Scarpa, Daniele, additional, Saccà, Salvatore, additional, Roncon, Loris, additional, Rizzetto, Francesca, additional, Purita, Paola, additional, Polo, Angela, additional, Pantano, Ivan, additional, Mugnolo, Antonio, additional, Molon, Giulio, additional, Meneghin, Samuele, additional, Mancuso, Daniela, additional, Lia, Micaela, additional, Grassi, Giuseppe, additional, Cutolo, Ada, additional, Chirillo, Fabio, additional, Bozzini, Paolo, additional, Bonapace, Stefano, additional, Anselmi, Maurizio, additional, Rigatelli, Gianluca, additional, and Bilato, Claudio, additional

Published
2022
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25. Case 34

Author

Rossillo, Antonio, Themistoclakis, Sakis, Bonso, Aldo, Corrado, Andrea, Raviele, Antonio, Natale, Andrea, editor, Al-Ahmad, Amin, editor, Wang, Paul J., editor, and DiMarco, John, editor

Published
2011
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26. Optimization of coronary sinus lead placement targeted to the longest right‐to‐left delay in patients undergoing cardiac resynchronization therapy: The Optimal Pacing SITE 2 (OPSITE 2) acute study and protocol

Author

Oddone, Daniele, Solari, Diana, Nangah, René, Arena, Giuseppe, Mureddu, Roberto, Giorgi, Davide, Sitta, Nadir, Bottoni, Nicola, Senatore, Gaetano, Giaccardi, Marzia, Giammaria, Massimo, Themistoclakis, Sakis, Laffi, Mattia, Cipolla, Eliana, Di Lorenzo, Fabio, Carpi, Romina, and Brignole, Michele

Published
2017
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28. European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE)

Author

Katritsis, Demosthenes G., Boriani, Giuseppe, Cosio, Francisco G., Hindricks, Gerhard, Jaïs, Pierre, Josephson, Mark E., Keegan, Roberto, Kim, Young-Hoon, Knight, Bradley P., Kuck, Karl-Heinz, Lane, Deirdre A., Lip, Gregory Y. H., Malmborg, Helena, Oral, Hakan, Pappone, Carlo, Themistoclakis, Sakis, Wood, Kathryn A., Blomström-Lundqvist, Carina, Gorenek, Bulent, Dagres, Nikolaos, Dan, Gheorge-Andrei, Vos, Marc A, Kudaiberdieva, Gulmira, Crijns, Harry, Roberts-Thomson, Kurt, Lin, Yenn-Jiang, Vanegas, Diego, Caorsi, Walter Reyes, Cronin, Edmond, and Rickard, Jack

Published
2017
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30. Fragmented and delayed electrograms within fibrofatty scar predict arrhythmic events in arrhythmogenic right ventricular cardiomyopathy: Results from a prospective risk stratification study

Author

Santangeli, Pasquale, Dello Russo, Antonio, Pieroni, Maurizio, Casella, Michela, Di Biase, Luigi, Burkhardt, J. David, Sanchez, Javier, Lakkireddy, Dhanunjaya, Carbucicchio, Corrado, Zucchetti, Martina, Pelargonio, Gemma, Themistoclakis, Sakis, Camporeale, Antonia, Rossillo, Antonio, Beheiry, Salwa, Hongo, Richard, Bellocci, Fulvio, Tondo, Claudio, and Natale, Andrea

Published
2012
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31. Arterial stiffness and atrial fibrillation: shared mechanisms, clinical implications and therapeutic options

Author

Vio, Riccardo, primary, Giordani, Andrea S., additional, Stefil, Maria, additional, Madine, Jillian, additional, Fairbairn, Timothy, additional, Themistoclakis, Sakis, additional, Salvi, Paolo, additional, Caforio, Alida L.P., additional, Shantsila, Alena, additional, Shantsila, Eduard, additional, Akhtar, Riaz, additional, Field, Mark, additional, Lip, Gregory Y.H., additional, and Proietti, Riccardo, additional

Published
2022
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33. MP-483499-008 PERSISTENT ATRIAL FIBRILLATION PATIENTS UNDERGOING PULMONARY VEIN AND POSTERIOR WALL ISOLATION WITH PULSED FIELD TECHNOLOGY: A MULTICENTER, NATIONWIDE, REAL-WORLD EXPERIENCE

Author

Schiavone, Marco, Russo, Antonio Dello, Solimene, Francesco, Iacopino, Saverio, Bianchi, Stefano, Fassini, Gaetano, Volpato, Giovanni, Schillaci, Vincenzo, Rossillo, Antonio, Maggio, Ruggero, Filannino, Pasquale, Themistoclakis, Sakis, Compagnucci, Paolo, Moltrasio, Massimo, Casella, Michela, Malacrida, Maurizio, and Tondo, Claudio

Published
2024
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34. Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration

Author

Bristol-Myers Squibb, Pfizer, Bayer, iRhythm Technologies, Daiichi-Sankyo, Zenicor, Servier, Boehringer Ingelheim Fonds, Biotel, Canadian Stroke Prevention Intervention Network, Omron, Fonds de Recherche du Québec, Rivard, Léna, Friberg, Leif, Conen, David, Healey, Jeffrey S., Berge, Trygve, Boriani, Giuseppe, Brandes, Axel, Calkins, Hugh, Camm, A John, Yee Chen, Lin, Clúa-Espuny, Josep Lluis, Collins, Ronan, Connolly, Stuart, Dagres, Nikolaos, Elkind, Mitchell S. V., Engdahl, Johan, Field, Thalia S., Gersh, Bernard J., Glotzer, Taya V., Hankey, Graeme J., Harbison, Joseph A., Haeusler, Karl G., Hills, Mellanie T., Johnson, Linda S. B., Joung, Boyoung, Khairy, Paul, Kirchhof, Paulus, Krieger, Derk, Lip, Gregory Y. H., Løchen, Maja-Lisa, Madhavan, Malini, Mairesse, Georges H., Montaner, Joan, Ntaios, George, Quinn, Terence J., Rienstra, Michiel, Rosenqvist, Mårten, Sandhu, Roopinder K., Smyth, Breda, Schnabel, Renate B., Stavrakis, Stavros, Themistoclakis, Sakis, Van Gelder, Isabelle C., Wang, Ji-Guang, Freedman, Ben, Bristol-Myers Squibb, Pfizer, Bayer, iRhythm Technologies, Daiichi-Sankyo, Zenicor, Servier, Boehringer Ingelheim Fonds, Biotel, Canadian Stroke Prevention Intervention Network, Omron, Fonds de Recherche du Québec, Rivard, Léna, Friberg, Leif, Conen, David, Healey, Jeffrey S., Berge, Trygve, Boriani, Giuseppe, Brandes, Axel, Calkins, Hugh, Camm, A John, Yee Chen, Lin, Clúa-Espuny, Josep Lluis, Collins, Ronan, Connolly, Stuart, Dagres, Nikolaos, Elkind, Mitchell S. V., Engdahl, Johan, Field, Thalia S., Gersh, Bernard J., Glotzer, Taya V., Hankey, Graeme J., Harbison, Joseph A., Haeusler, Karl G., Hills, Mellanie T., Johnson, Linda S. B., Joung, Boyoung, Khairy, Paul, Kirchhof, Paulus, Krieger, Derk, Lip, Gregory Y. H., Løchen, Maja-Lisa, Madhavan, Malini, Mairesse, Georges H., Montaner, Joan, Ntaios, George, Quinn, Terence J., Rienstra, Michiel, Rosenqvist, Mårten, Sandhu, Roopinder K., Smyth, Breda, Schnabel, Renate B., Stavrakis, Stavros, Themistoclakis, Sakis, Van Gelder, Isabelle C., Wang, Ji-Guang, and Freedman, Ben

Abstract

Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of best available evidence. The document also addresses suspected pathophysiologic mechanisms and identifies knowledge gaps for future research. Whereas AF and dementia share numerous risk factors, the association appears to be independent of these variables. Nevertheless, the evidence remains inconclusive regarding a direct causal effect. Several pathophysiologic mechanisms have been proposed, some of which are potentially amenable to early intervention, including cerebral microinfarction, AF-related cerebral hypoperfusion, inflammation, microhemorrhage, brain atrophy, and systemic atherosclerotic vascular disease. The mitigating role of oral anticoagulation in specific subgroups (eg, low stroke risk, short duration or silent AF, after successful AF ablation, or atrial cardiopathy) and the effect of rhythm versus rate control strategies remain unknown. Likewise, screening for AF (in cognitively normal or cognitively impaired patients) and screening for cognitive impairment in patients with AF are debated. The pathophysiology of dementia and therapeutic strategies to reduce cognitive impairment warrant further investigation in individuals with AF. Cognition should be evaluated in future AF studies and integrated with patient-specific outcome priorities and patient preferences. Further large-scale prospective studies and randomized trials are needed to establish whether AF is a risk factor for cognitive impairment, to investigate strategies to prevent dementia, and to determine whether screening for unknown AF followed by targeted therapy might prevent or reduce cognitive impair

Published
2022

35. MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial

Author

Haeusler, Karl Georg, primary, Eichner, Felizitas A., additional, Heuschmann, Peter U., additional, Fiebach, Jochen B., additional, Engelhorn, Tobias, additional, Blank, Benjamin, additional, Callans, David, additional, Elvan, Arif, additional, Grimaldi, Massimo, additional, Hansen, Jim, additional, Hindricks, Gerhard, additional, Al-Khalidi, Hussein R., additional, Mont, Lluis, additional, Nielsen, Jens Cosedis, additional, Piccini, Jonathan P., additional, Schotten, Ulrich, additional, Themistoclakis, Sakis, additional, Vijgen, Johan, additional, Di Biase, Luigi, additional, and Kirchhof, Paulus, additional

Published
2022
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36. In vivo Lesion Index (LSI) validation in percutaneous radiofrequency catheter ablation

Author

Themistoclakis, Sakis, primary, Calzolari, Vittorio, additional, De Mattia, Luca, additional, China, Paolo, additional, Dello Russo, Antonio, additional, Fassini, Gaetano, additional, Casella, Michela, additional, Caporaso, Igor, additional, Indiani, Stefano, additional, Addis, Alessandro, additional, Basso, Cristina, additional, Della Barbera, Mila, additional, Thiene, Gaetano, additional, and Tondo, Claudio, additional

Published
2022
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37. OUTCOME OF DIFFERENT ABLATION STRATEGIES IN PERSISTENT AND LONG-STANDING PERSISTENT ATRIAL FIBRILLATION: RESULTS FROM A MULTICENTER RANDOMIZED TRIAL (TANTRA)

Author

Mohanty, Sanghamitra, primary, Mohanty, Prasant, additional, Trivedi, Chintan, additional, Casella, Michela, additional, Russo, Antonio Dello, additional, Compagnucci, Paolo, additional, Rocca, Domenico Giovanni Della, additional, Gianni, Carola, additional, China, Paolo, additional, Themistoclakis, Sakis, additional, MacDonald, Bryan, additional, Mayedo, Angel, additional, Al-Ahmad, Amin, additional, Horton, Rodney P., additional, Bassiouny, Mohamed, additional, Gallinghouse, Gerald, additional, Burkhardt, John, additional, Biase, Luigi Di, additional, Tondo, Claudio, additional, and Natale, Andrea, additional

Published
2022
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38. Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration

Author

Rivard, Léna, primary, Friberg, Leif, additional, Conen, David, additional, Healey, Jeffrey S., additional, Berge, Trygve, additional, Boriani, Giuseppe, additional, Brandes, Axel, additional, Calkins, Hugh, additional, Camm, A. John, additional, Yee Chen, Lin, additional, Lluis Clua Espuny, Josep, additional, Collins, Ronan, additional, Connolly, Stuart, additional, Dagres, Nikolaos, additional, Elkind, Mitchell S.V., additional, Engdahl, Johan, additional, Field, Thalia S., additional, Gersh, Bernard J., additional, Glotzer, Taya V., additional, Hankey, Graeme J., additional, Harbison, Joseph A., additional, Georg Haeusler, Karl, additional, Hills, Mellanie T., additional, Johnson, Linda S.B., additional, Joung, Boyoung, additional, Khairy, Paul, additional, Kirchhof, Paulus, additional, Krieger, Derk, additional, Lip, Gregory Y.H., additional, Løchen, Maja-Lisa, additional, Madhavan, Malini, additional, Mairesse, Georges H., additional, Montaner, Joan, additional, Ntaios, George, additional, Quinn, Terence J., additional, Rienstra, Michiel, additional, Rosenqvist, Mårten, additional, Sandhu, Roopinder K., additional, Smyth, Breda, additional, Schnabel, Renate B., additional, Stavrakis, Stavros, additional, Themistoclakis, Sakis, additional, Van Gelder, Isabelle C., additional, Wang, Ji-Guang, additional, and Freedman, Ben, additional

Published
2022
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39. Clinical Outcomes of Left Atrial Appendage Occlusion in Patients with Previous Intracranial or Gastrointestinal Bleeding: Insights from the Logic (Left Atrial Appendage Occlusion in Patients with Gastrointestinal or Intracranial Bleeding) International Multicenter Registry

Author

Gallo, Francesco, primary, Ronco, Federico, additional, D&apos;Amico, Gianpiero, additional, Della Rocca, Domenico, additional, Mazzone, Patrizio, additional, Bordignon, Stefano, additional, Casu, Gavino, additional, Giannini, Francesco, additional, Berti, Sergio, additional, Horton, Rodnay, additional, D&apos;Angelo, Giuseppe, additional, Urbanek, Lukas, additional, Merella, Pierluigi, additional, Ruggiero, Rossella, additional, Romeo, Maria Rita, additional, Bosica, Francesco, additional, Schmidt, Boris, additional, Atzori, Enrico, additional, Barbierato, Marco, additional, Natale, Andrea, additional, and Themistoclakis, Sakis, additional

Published
2022
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40. Corrigendum to: Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST-AFNET 4 trial

Author

Metzner, Andreas, primary, Suling, Anna, additional, Brandes, Axel, additional, Breithardt, Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, Lars, additional, Elvan, Arif, additional, Goette, Andreas, additional, Haegeli, Laurent M, additional, Heidbuchel, Hein, additional, Kautzner, Josef, additional, Kuck, Karl-Heinz, additional, Mont, Luis, additional, Ng, G Andre, additional, Szumowski, Lukasz, additional, Themistoclakis, Sakis, additional, van Gelder, Isabelle C, additional, Vardas, Panos, additional, Wegscheider, Karl, additional, Willems, Stephan, additional, and Kirchhof, Paulus, additional

Published
2021
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41. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference

Author

Kirchhof, Paulus, Breithardt, Günter, Bax, Jeroen, Benninger, Gerlinde, Blomstrom-Lundqvist, Carina, Boriani, Giuseppe, Brandes, Axel, Brown, Helen, Brueckmann, Martina, Calkins, Hugh, Calvert, Melanie, Christoffels, Vincent, Crijns, Harry, Dobrev, Dobromir, Ellinor, Patrick, Fabritz, Larissa, Fetsch, Thomas, Freedman, S. Ben, Gerth, Andrea, Goette, Andreas, Guasch, Eduard, Hack, Guido, Haegeli, Laurent, Hatem, Stephane, Haeusler, Karl Georg, Heidbüchel, Hein, Heinrich-Nols, Jutta, Hidden-Lucet, Francoise, Hindricks, Gerd, Juul-Möller, Steen, Kääb, Stefan, Kappenberger, Lukas, Kespohl, Stefanie, Kotecha, Dipak, Lane, Deirdre A., Leute, Angelika, Lewalter, Thorsten, Meyer, Ralf, Mont, Lluis, Münzel, Felix, Nabauer, Michael, Nielsen, Jens C., Oeff, Michael, Oldgren, Jonas, Oto, Ali, Piccini, Jonathan P., Pilmeyer, Art, Potpara, Tatjana, Ravens, Ursula, Reinecke, Holger, Rostock, Thomas, Rustige, Joerg, Savelieva, Irene, Schnabel, Renate, Schotten, Ulrich, Schwichtenberg, Lars, Sinner, Moritz F., Steinbeck, Gerhard, Stoll, Monika, Tavazzi, Luigi, Themistoclakis, Sakis, Tse, Hung Fat, Van Gelder, Isabelle C., Vardas, Panagiotis E., Varpula, Timo, Vincent, Alphons, Werring, David, Willems, Stephan, Ziegler, André, Lip, Gregory Y.H., and Camm, A. John

Published
2016
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42. Searching for Atrial Fibrillation Poststroke

Author

Lis Neubeck, Alejandro Bustamante, Tatjana S. Potpara, Antonio Luiz Pinho Ribeiro, Joan Montaner, Michiel Rienstra, Barbara Casadei, Karl Georg Haeusler, Terence J. Quinn, Tissa Wijeratne, Wolfram Doehner, Jonathan P. Piccini, Isabelle C. Van Gelder, Mårten Rosenqvist, David J. Gladstone, Linda S B Johnson, Jeff S. Healey, Gregory Y.H. Lip, Derk W. Krieger, Ben Freedman, Jesper Hastrup Svendsen, Georges H. Mairesse, Taya V. Glotzer, Axel Brandes, Johannes Brachmann, FD Richard Hobbs, Gunnar Engström, Paulus Kirchhof, Bernard Yan, Themistoclakis Sakis, Graeme J. Hankey, Leif Friberg, Renate B. Schnabel, Joseph Harbison, Laurent Fauchier, James A. Reiffel, Giuseppe Boriani, Rolf Wachter, George Ntaios, Shinya Goto, Maja-Lisa Løchen, Eleni Korompoki, Harry J.G.M. Crijns, Moritz F. Sinner, Hooman Kamel, and Cardiovascular Centre (CVC)

Subjects
Male, Heart disease, Atrial enlargement, Cost effectiveness, INSERTABLE CARDIAC MONITORS, 030204 cardiovascular system & hematology, Brain Ischemia, COST-EFFECTIVENESS, Brain ischemia, Electrocardiography, Brain Ischemia/complications, 0302 clinical medicine, Atrial Fibrillation, atrial fibrillation, SECONDARY STROKE PREVENTION, Stroke, Aspirin, medicine.diagnostic_test, Atrial fibrillation, stroke, anticoagulants, cardiomyopathies, electrocardiography, 3. Good health, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Thromboembolism/diagnosis, medicine.drug, medicine.medical_specialty, UNDETERMINED SOURCE, 03 medical and health sciences, Thromboembolism, Physiology (medical), Internal medicine, SCORE, Atrial Fibrillation/diagnosis, medicine, Humans, cardiovascular diseases, Aged, HEALTH-CARE PROFESSIONALS, EMBOLIC STROKE, CRYPTOGENIC STROKE, business.industry, medicine.disease, TRANSIENT ISCHEMIC ATTACK, RISK-FACTORS, business, 030217 neurology & neurosurgery, Stroke/complications
Abstract

Cardiac thromboembolism attributed to atrial fibrillation (AF) is responsible for up to one-third of ischemic strokes. Stroke may be the first manifestation of previously undetected AF. Given the efficacy of oral anticoagulants in preventing AF-related ischemic strokes, strategies of searching for AF after a stroke using ECG monitoring followed by oral anticoagulation (OAC) treatment have been proposed to prevent recurrent cardioembolic strokes. This white paper by experts from the AF-SCREEN International Collaboration summarizes existing evidence and knowledge gaps on searching for AF after a stroke by using ECG monitoring. New AF can be detected by routine plus intensive ECG monitoring in approximately one-quarter of patients with ischemic stroke. It may be causal, a bystander, or neurogenically induced by the stroke. AF after a stroke is a risk factor for thromboembolism and a strong marker for atrial myopathy. After acute ischemic stroke, patients should undergo 72 hours of electrocardiographic monitoring to detect AF. The diagnosis requires an ECG of sufficient quality for confirmation by a health professional with ECG rhythm expertise. AF detection rate is a function of monitoring duration and quality of analysis, AF episode definition, interval from stroke to monitoring commencement, and patient characteristics including old age, certain ECG alterations, and stroke type. Markers of atrial myopathy (eg, imaging, atrial ectopy, natriuretic peptides) may increase AF yield from monitoring and could be used to guide patient selection for more intensive/prolonged poststroke ECG monitoring. Atrial myopathy without detected AF is not currently sufficient to initiate OAC. The concept of embolic stroke of unknown source is not proven to identify patients who have had a stroke benefitting from empiric OAC treatment. However, some embolic stroke of unknown source subgroups (eg, advanced age, atrial enlargement) might benefit more from non–vitamin K-dependent OAC therapy than aspirin. Fulfilling embolic stroke of unknown source criteria is an indication neither for empiric non–vitamin K-dependent OAC treatment nor for withholding prolonged ECG monitoring for AF. Clinically diagnosed AF after a stroke or a transient ischemic attack is associated with significantly increased risk of recurrent stroke or systemic embolism, in particular, with additional stroke risk factors, and requires OAC rather than antiplatelet therapy. The minimum subclinical AF duration required on ECG monitoring poststroke/transient ischemic attack to recommend OAC therapy is debated.

Published
2019
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43. Pulmonary Vein Isolation to Reduce Future Risk of Atrial Fibrillation in Patients Undergoing Typical Flutter Ablation: Results from a Randomized Pilot Study (REDUCE AF)

Author

MOHANTY, SANGHAMITRA, NATALE, ANDREA, MOHANTY, PRASANT, DI BIASE, LUIGI, TRIVEDI, CHINTAN, SANTANGELI, PASQUALE, BAI, RONG, BURKHARDT, DAVID J., GALLINGHOUSE, JOSEPH G., HORTON, RODNEY, SANCHEZ, JAVIER E., HRANITZKY, PATRICK M., AL-AHMAD, AMIN, HAO, STEVEN, HONGO, RICHARD, BEHEIRY, SALWA, PELARGONIO, GEMMA, FORLEO, GIOVANNI, ROSSILLO, ANTONIO, THEMISTOCLAKIS, SAKIS, CASELLA, MICHELA, RUSSO, ANTONIO DELLO, TONDO, CLAUDIO, and DIXIT, SANJAY

Published
2015
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44. Impact of type of atrial fibrillation and repeat catheter ablation on long-term freedom from atrial fibrillation: Results from a multicenter study

Author

Bhargava, Mandeep, Di Biase, Luigi, Mohanty, Prasant, Prasad, Subramanyam, Martin, David O., Williams-Andrews, Michelle, Wazni, Oussama M., Burkhardt, J. David, Cummings, Jennifer E., Khaykin, Yaariv, Verma, Atul, Hao, Steven, Beheiry, Salwa, Hongo, Richard, Rossillo, Antonio, Raviele, Antonio, Bonso, Aldo, Themistoclakis, Sakis, Stewart, Kelly, Saliba, Walid I., Schweikert, Robert A., and Natale, Andrea

Published
2009
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46. Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial

Author

Metzner, Andreas, primary, Suling, Anna, additional, Brandes, Axel, additional, Breithardt, , Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, , Lars, additional, Elvan, , Arif, additional, Goette, , Andreas, additional, Haegeli, , Laurent M, additional, Heidbuchel, , Hein, additional, Kautzner, , Josef, additional, Kuck, , Karl-Heinz, additional, Mont, , Luis, additional, Ng, G Andre, additional, Szumowski, , Lukasz, additional, Themistoclakis, , Sakis, additional, van Gelder, , Isabelle C, additional, Vardas, , Panos, additional, Wegscheider, , Karl, additional, Willems, , Stephan, additional, and Kirchhof, Paulus, additional

Published
2021
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47. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial

Author

Willems, Stephan, primary, Borof, Katrin, additional, Brandes, Axel, additional, Breithardt, Günter, additional, Camm, A John, additional, Crijns, Harry J G M, additional, Eckardt, Lars, additional, Gessler, Nele, additional, Goette, Andreas, additional, Haegeli, Laurent M, additional, Heidbuchel, Hein, additional, Kautzner, Josef, additional, Ng, G André, additional, Schnabel, Renate B, additional, Suling, Anna, additional, Szumowski, Lukasz, additional, Themistoclakis, Sakis, additional, Vardas, Panos, additional, van Gelder, Isabelle C, additional, Wegscheider, Karl, additional, and Kirchhof, Paulus, additional

Published
2021
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50. Prospective European Survey on Atrial Fibrillation Ablation: Clinical Characteristics of Patients and Ablation Strategies Used in Different Countries

Author

THEMISTOCLAKIS, SAKIS, RAVIELE, ANTONIO, CHINA, PAOLO, PAPPONE, CARLO, DE PONTI, ROBERTO, REVISHVILI, AMIRAN, ALIOT, ETIENNE, KUCK, KARL-HEINZ, HOFF, PER IVAR, SHAH, DIPEN, ALMENDRAL, JESÚS, MANOLIS, ANTONIS S., CHIERCHIA, GIAN-BATTISTA, OTO, ALI, VATASESCU, RADU G., SINKOVEC, MATJAZ, and CAPPATO, RICCARDO

Published
2014
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