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Your search keyword '"Theißen, Alexander"' showing total 9 results
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9 results on '"Theißen, Alexander"'

1. Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury

Author

Billig, Sebastian, primary, Hein, Marc, additional, Kirchner, Celine, additional, Schumacher, David, additional, Habigt, Moriz Aljoscha, additional, Mechelinck, Mare, additional, Fuchs, Dieter, additional, Klinge, Uwe, additional, Theißen, Alexander, additional, Beckers, Christian, additional, Bleilevens, Christian, additional, Kramann, Rafael, additional, and Uhlig, Moritz, additional

Published
2024
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6. Taurine as Antioxidant in a Novel Cell- and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys

Author

Zarnitz, Laura, primary, Doorschodt, Benedict M., additional, Ernst, Lisa, additional, Hosseinnejad, Aisa, additional, Edgworth, Eileen, additional, Fechter, Tamara, additional, Theißen, Alexander, additional, Djudjaj, Sonja, additional, Boor, Peter, additional, Rossaint, Rolf, additional, Tolba, René H., additional, and Bleilevens, Christian, additional

Published
2023
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8. Influence of Vitamin C on Antioxidant Capacity of In Vitro Perfused Porcine Kidneys

Author

Bleilevens, Christian, primary, Doorschodt, Benedict M., additional, Fechter, Tamara, additional, Grzanna, Tim, additional, Theißen, Alexander, additional, Liehn, Elisa A., additional, Breuer, Thomas, additional, Tolba, René H., additional, Rossaint, Rolf, additional, Stoppe, Christian, additional, Boor, Peter, additional, Hill, Aileen, additional, and Fabry, Gregor, additional

Published
2019
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9. Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis.

Author

Korte J, Lauwigi T, Herzog L, Theißen A, Suchorski K, Strudthoff LJ, Focke J, Jansen SV, Gries T, Rossaint R, Bleilevens C, and Winnersbach P

Subjects
Humans, Extracorporeal Membrane Oxygenation, Biosensing Techniques, Oxygenators, Membrane, Thrombosis, Electric Impedance
Abstract

Blood clot formation inside the membrane oxygenator (MO) remains a risk in extracorporeal membrane oxygenation (ECMO). It is associated with thromboembolic complications and normally detectable only at an advanced stage. Established clinical monitoring techniques lack predictive capabilities, emphasizing the need for refinement in MO monitoring towards an early warning system. In this study, an MO was modified by integrating four sensor fibers in the middle of the hollow fiber mat bundle, allowing for bioimpedance measurement within the MO. The modified MO was perfused with human blood in an in vitro test circuit until fulminant clot formation. The optical analysis of clot residues on the extracted hollow fibers showed a clot deposition area of 51.88% ± 14.25%. This was detectable via an increased bioimpedance signal with a significant increase 5 min in advance to fulminant clot formation inside the MO, which was monitored by the clinical gold standard (pressure difference across the MO (dp-MO)). This study demonstrates the feasibility of detecting clot growth early and effectively by measuring bioimpedance within an MO using integrated sensor fibers. Thus, bioimpedance may even outperform the clinical gold standard of dp-MO as a monitoring method by providing earlier clot detection.

Published
2024
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