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Eric Vivier, Laurent Brossay, Cyril Seillet, Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Heidelberg, VIC 3084, Australia, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., The Walter and Eliza Hall Institute of Medical Research (WEHI), Innate Pharma, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Guillermina Lozano, Terence P. Speed, Alan Herschtal, Thierry Soussi, Han Liang, Ygal Haupt, Sue Haupt, Franco Caramia, Hu Chen, University of Melbourne, Karolinska Institutet [Stockholm], Cancer Center Karolinska [Karolinska Institutet] (CCK), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), The University of Texas Medical School at Houston, MD Anderson Cancer Center [Houston], The University of Texas Health Science Center at Houston (UTHealth), Baylor College of Medicine (BCM), Baylor University, The University of Texas M.D. Anderson Cancer Center [Houston], The Walter and Eliza Hall Institute for Medical Research (WEHI), Monash University [Melbourne], École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and The Walter and Eliza Hall Institute of Medical Research (WEHI)

Kloprogge, F, Workman, Borrmann, Tékété, Lefèvre, Hamed, Piola, Ursing, Kofoed, Mårtensson, Ngasala, Björkman, Ashton, Hietala, Aweeka, Parikh, Mwai, Davis, Karunajeewa, Salman, Checchi, Fogg, Newton, PN, Mayxay, M, Deloron, Faucher, Nosten, F, Ashley, E, McGready, R, Vugt, v, Proux, S, Price, R, Karbwang, Ezzet, Bakshi, Stepniewska, K, White, N, Guerin, P, Barnes, Tarning, J, Institute for Global Health, Imperial College London, Institute for Tropical Medicine [Tübingen, Germany], University of Tübingen [Germany], Département d'Epidémiologie des Affections parasitaires, Malaria Research and training center Université de Bamako, Mali, Université de Bamako, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Department of Microbiology, Tumour and Cell biology [Stockholm, Sweden] (Malaria Research), Karolinska Institutet [Stockholm], Bandim Health Project, International Network for the Demographic Evaluation of Populations and Their Health (INDEPTH Network), Department of Women's and Children's Health [Uppsala, Sweden], Uppsala University-International Maternal and Child Healt [Uppsala, Sweden] (IMCH), Muhimbili University of Health and Allied Sciences, University of Gothenburg (GU), Université d'Uppsala et Gothenburg, University of California [San Francisco] (UCSF), University of California, Yale School of Public Health (YSPH), Kenya Medical Research Institute (KEMRI), Medical School [Australian National University - ANU], Australian National University (ANU), The Walter and Eliza Hall Institute of Medical Research, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Epicentre [Paris] [Médecins Sans Frontières], Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahidol University [Bangkok]-Mahosot Hospital, Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital-Microbiology Laboratory, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford [Oxford], Shoklo Malaria Research Unit [Mae Sot, Thailand] (Faculty of Tropical Medicine), Mahidol University [Bangkok]-Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford [Oxford]-Mahidol University [Bangkok]-Wellcome Trust-University of Oxford [Oxford]-Wellcome Trust, Global Health Division, Menzies School of Health Research, Nagasaki University, Centre for Tropical Medicine and Global Health, University of Oxford, Mahidol Oxford Tropical Medicine Research Unit, University of Oxford [Oxford]-Mahidol University [Bangkok], Institute for Tropical Medicine = Institut für Tropenmedizin, Reisemedizin, Humanparasitolgie [Tübingen, Allemagne] (ITM), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Department of Women and Children's Health, Uppsala University, The Walter and Eliza Hall Institute of Medical Research (WEHI), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford [Oxford]-University of Oxford [Oxford], Shoklo Malaria Research Unit [Mae Sot, Thailand] (SMRU), Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford [Oxford]-Mahidol University [Bangkok]-Wellcome Trust-University of Oxford [Oxford]-Mahidol University [Bangkok]-Wellcome Trust, Infectious diseases, APH - Global Health, APH - Quality of Care, AII - Infectious diseases, Wellcome Trust-Mahidol University [Bangkok]-University of Oxford [Oxford]-Wellcome Trust-Mahidol University [Bangkok]-University of Oxford [Oxford], and Beeson, James G.

Ayers, Katie, Eggers, Stefanie, Rollo, Ben, Smith, Katherine, Davidson, Nadia, Siddall, Nicole, Zhao, Liang, Bowles, Josephine, Weiss, Karin, Zanni, Ginevra, Burglen, Lydie, Ben-Shachar, Shay, Rosensaft, Jenny, Raas-Rothschild, Annick, Jørgensen, Anne, Schittenhelm, Ralf, Huang, Cheng, Robevska, Gorjana, van den Bergen, Jocelyn, Casagranda, Franca, Cyza, Justyna, Pachernegg, Svenja, Wright, David, Bahlo, Melanie, Oshlack, Alicia, O'Brien, Terrence, Kwan, Patrick, Koopman, Peter, Hime, Gary, Girard, Nadine, Hoffmann, Chen, Shilon, Yuval, Zung, Amnon, Bertini, Enrico, Milh, Mathieu, Ben Rhouma, Bochra, Belguith, Neila, Bashamboo, Anu, Mcelreavey, Ken, Banne, Ehud, Weintrob, Naomi, Benzeev, Bruria, Sinclair, Andrew, Murdoch Children's Research Institute (MCRI), University of Melbourne, Victorian Clinical Genetics Services, Monash University [Melbourne], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Queensland [Brisbane], Technion - Israel Institute of Technology [Haifa], Bambino Gesù Children’s Hospital [Rome, Italy], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Génétique des Troubles du Neurodéveloppement = Developmental Brain Disorders Laboratory (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Tel Aviv Sourasky Medical Center [Te Aviv], The Hebrew University Hadassah Medical School, Chaim Sheba Medical Center, Tel Aviv University (TAU), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Monash University [Clayton], Peter Mac Callum Cancer Centre, Service de pédiatrie et neurologie pédiatrique, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Kaplan Medical Center [Rehovot, Israel], Université de Gabès, Université de Sfax - University of Sfax, Hôpital Charles Nicolle [Tunis], Génétique du Développement humain - Human developmental genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Wolfson Medical Center, This study was supported by a National Health and Medical Research Council (NHMRC) programme grant (1074258) awarded to AS, NHMRC project grant (1156942) (K.A.), a Medical Research Future Fund Stem Cells Mission grant (MRF1201781) (K.A., B.N.R. and P.Kw), an Australian Research Council Future Fellowship (FT100100764) to M.B., A NHMRC Investigator Grant (1174040) to D.W., Agence Nationale de la Recherche funding ANR-10-LABX-73 REVIVE, ANR-17-CE14-0038-01 and ANR 20 CE14 0007 to K.M., ANR-19-CE140022 and ANR-19-CE14-0012 to A.B., G.Z. and E.B. are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), ANR-20-CE14-0007,Goldilocks,Analyse intégrée du rôle du facteur de transcription SF-1 / NR5A1 et de ses gènes cibles dépendants du dosage dans la fonction gonadique et les troubles du développement sexuel (DSD)(2020), ANR-19-CE14-0022,SexDiff,Régulation de la détermination du sexe et de la différenciation ovarienne : implications dans les troubles du développement sexuel(2019), and ANR-19-CE14-0012,RNA-SEX,Fonction de l'ARN hélicase dans la détermination du sexe chez les vertébrés et les troubles du développement du sexe chez l'homme (DSD)(2019)

Štefan Janeček, Rohan J. Williams, Geoff Pincher, Darrell Cockburn, Gurvan Michel, Wataru Saburi, David R. Rose, Brian P. Rempel, Glyn R. Hemsworth, Wim Van den Ende, Jerry Ståhlberg, Leila LoLeggio, Tom Wennekes, Kiyohiko Igarashi, Cedric Montanier, Etienne Rebuffet, Naotake Konno, Harry J. Gilbert, Markus Linder, Ed Bayer, Tirso Pons, Jan-Hendrik Hehemann, Tomomi Sumida, Thierry Fontaine, Takane Katayama, Elizabeth Ficko-Blean, Florence Vincent, Zui Fujimoto, Masafumi Hidaka, Kyle Robinson, Ana R. Luís, Yuichi Sakamoto, Bernard Henrissat, Gustav Vaaje-Kolstad, Jens M. Eklöf, Ian R. Greig, Harry Brumer, Ryuichiro Suzuki, Mats Sandgren, Takashi Tonozuka, Ryszard Brzezinski, Brian L. Mark, Bareket Dassa, Haruhide Mori, Junho Lee, Vivian L. Y. Yip, Birte Svensson, Wade Abbott, Alfons K. G. Felice, Juha Rouvinen, Takayuki Ohnuma, Satoshi Kaneko, Franz J. St John, Ramon Hurtado-Guerrero, Pedro M. Coutinho, Sine Larsen, Gideon J. Davies, Yuval Shoham, Kiyotaka Fujita, Warren W. Wakarchuk, Fathima Aidha Shaikh, Alisdair B. Boraston, Breeanna R. Urbanowicz, Vincent G. H. Eijsink, Daniel Kracher, Beatrice Cobucci-Ponzano, Ethan D. Goddard-Borger, Anthony J. Clarke, David J. Vocadlo, Katsuro Yaoi, Seino A. K. Jongkees, Anna A. Kulminskaya, Roland Ludwig, Mirko M. Maksimainen, Magali Remaud-Simeon, Edward J. Taylor, Motomitsu Kitaoka, Spencer J. Williams, Shinya Fushinobu, Marco Moracci, David Wilson, Richard McLean, Toki Taira, Jean-Guy Berrin, Ran Zhang, Hiroyuki Nakai, Tracey M. Gloster, Peter J. Reilly, Wim Nerinckx, Takuya Ishida, Alicia Lammerts van Bueren, Orly Alber, Mirjam Czjzek, Kathleen Piens, Annabelle Varrot, Stephen G. Withers, Nathalie Juge, Maxime Versluys, Gerlind Sulzenbacher, Richard W. Pickersgill, Michael D. L. Suits, Agriculture and Agri-Food [Ottawa] (AAFC), Weizmann Institute of Science [Rehovot, Israël], Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), University of Victoria [Canada] (UVIC), University of British Columbia, Université de Sherbrooke (UdeS), University of Guelph, National Research Council (CNR), Pennsylvania State University (Penn State), Penn State System, Aix Marseille Université (AMU), Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), University of York, Norwegian University of Life Sciences (NMBU), University of Vienna [Vienna], University of Adelaide, Institut Pasteur [Paris], National Agriculture and Food Research Organization (NARO), Kagoshima University, University of Tokyo, Newcastle University, University of St Andrews [Scotland], The Walter and Eliza Hall Institute of Medical Research (WEHI), Simon Fraser University (SFU.ca), Max Planck Institute for Marine Microbiology, Max-Planck-Gesellschaft, University of Leeds, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Slovak Academy of Sciences (SAS), Quadram Institute, University of the Ryukyus [Okinawa], Ishikawa Prefectural University, Utsunomiya University [Utsunomiya], St Petersburg Nuclear Physics Institute, University of Groningen, Aalto University, University of Copenhagen = Københavns Universitet (KU), University of Lisbon, University of Oulu, University of Manitoba [Winnipeg], University of Lethbridge, Hokkaido University [Sapporo, Japan], Niigata University, Ghent University, Kinki University, Queen Mary University of London (QMUL), Sveriges lantbruksuniversitet, National Center for Biotechnology, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Iowa State University (ISU), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA), University of Waterloo [Waterloo], University of Eastern Finland, Iwate Biotechnology Research Center (IBRC), Technion - Israel Institute of Technology [Haifa], United States Department of Agriculture, Wilfrid Laurier University (WLU), Architecture et fonction des macromolécules biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Akita University, Danmarks Tekniske Universitet (DTU), University of Lincoln, Tokyo University of Agriculture and Technology (TUAT), Univ Georgia, University of Georgia [USA], Université Catholique de Louvain = Catholic University of Louvain (UCL), Centre de Recherches sur les Macromolécules Végétales (CERMAV ), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ryerson University, Utrecht University [Utrecht], University of Melbourne, Cornell University [New York], National Institute of Advanced Industrial Science and Technology (AIST), Natural Sciences and Engineering Research Council of Canada (NSERC), Agriculture and Agri-Food (AAFC), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Biotechnology and Biological Sciences Research Council (BBSRC), University of Copenhagen = Københavns Universitet (UCPH), Universidade de Lisboa = University of Lisbon (ULISBOA), Universiteit Gent = Ghent University (UGENT), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Weizmann Institute of Science, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Recherche Agronomique (INRA), University of Victoria, Sherbrooke University, Sorbonne Universités, University of Vienna, National Agriculture and Food Research Organization, University of St Andrews, Walter and Eliza Hall Institute of Medical Research (WEHI), Slovak Academy of Sciences, Utsunomiya University, Hokkaido University, Iwate Biotechnol Res Ctr, Technion – Israel Institute of Technology, Akita Prefectural University, Université Catholique de Louvain (UCL), Centre de Recherches sur les Macromolécules Végétales (CERMAV), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA), Cornell University, Laboratoire Départemental Vétérinaire et d'Hygiène Alimentaire des Hautes Alpes, and Moracci, M

Eva De Smedt, Bieke Soen, Marta Monguió-Tortajada, Jasper Anckaert, Erminia Romano, Els Beghein, Hina Kalra, Alessandra Lo Cicero, Michael W. Pfaffl, Laurence Bertier, Bert Dhondt, Edward Geeurickx, Özden Akay, Lorraine O'Driscoll, Frederik J. Verweij, Alan Van Goethem, Dominik Buschmann, Olivier De Wever, Zoraida Andreu Martinez, Susanne G. van der Grein, Carina Leonelli, Vincent Hyenne, Shu Liu, Prabhu Mathiyalagan, Guillaume van Niel, Andrew D Foers, Niels Vandamme, Joeri Tulkens, Petra Leidinger, Jan Van Deun, James Brian Byrd, Suzanne Vanhauwaert, David Kim, Patrizia Agostinis, Seyma Demirsoy, Esther N. M. Nolte-‘t Hoen, Stephanie Boukouris, Aleksandra M. Dudek, Michel Bremer, Anna Cmoch, Sandra Kraemer, Kathrin Gärtner, Clotilde Théry, Hetty Helsmoortel, Farzaneh Ghazavi, Pieter Mestdagh, Dillon C. Muth, Jo Vandesompele, Grace V. Hancock, Lien Lippens, Tom Groot Kormelink, Tom A. P. Driedonks, Abdou ElSharawy, Sushma Anand, Marijke I. Zonneveld, Benjamin J. Scicluna, Joanna Kowal, Susmita Sahoo, Lesley Cheng, Safia Thaminy, Isabel Van Audenhove, Suresh Mathivanan, Ilaria Floris, Glenn Vergauwen, Geert Berx, Jan Gettemans, Johannes V. Swinnen, Yaxuan Liang, Victoria Depoorter, Shaun Martin, Alexander R. van Vliet, Natalia G. Sampaio, Martijn J. C. van Herwijnen, Bernd Giebel, Abhishek D. Garg, Bjarke Primdal-Bengtson, An Hendrix, Gloria Milani, Tamás Matusek, Liselot Mus, Annelynn Wallaert, Andrew F. Hill, Roberta Palmulli, Maarit Takatalo, Tine Baetens, Clara Casert, Janneke Boere, Monisha Samuel, Marca H. M. Wauben, Nadine Van Roy, Delphine Daveloose, Anneleen Steels, Andrea Németh, Kenneth W. Witwer, Quentin Rousseau, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Universiteit Gent = Ghent University [Belgium] (UGENT), Center for Medical Genetics, Cancer Research Institute Ghent (CRIG), Bioinformatics Institute Ghent (BIG), Cell Death Research & Therapy (CDRT) Lab, Université Catholique de Louvain = Catholic University of Louvain (UCL), Molecular and Cellular Oncology Lab, Inflammation Research Center, VIB, Department of Biomedical Molecular Biology, Cancer Research Institute Ghent (CRIG), Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Hospital Santa Cristina Instituto de Investigación Sanitaria Princesa C, Unidad de Investigación, Department of Biochemistry, Faculty of Medicine and Health Sciences, Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University [Utrecht], Institute for Transfusion Medicine, University Hospital Essen, Universität Duisburg-Essen [Essen], Animal Physiology and Immunology, School of Life Sciences, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Laboratory of Cytometry, Department of Internal Medicine, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Department of Biochemistry, Hôpital Lapeyronie, Institute of Clinical Molecular Biology, Kiel University, Faculty of Sciences, Division of Biochemistry, Chemistry Department, Damietta University, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Department of Biochemistry, Microbiology and Immunology, University of Ottawa [Ottawa], Inflammation Division, The Walter and Eliza Hall Institute of Medical Research (WEHI), Department of Medical Biology, Hacettepe University Faculty of Medicine, Partner site Munich, German Centre for Infection Research (DZIF), Research Unit Gene Vectors, Helmholtz-Zentrum München (HZM), Department of Molecular and Comparative Pathobiology and Department of Neurology, Johns Hopkins University School of Medicine, Fédération de Médecine Translationelle de Strasbourg (FMTS), LabEx Medalis, Université de Strasbourg (UNISTRA), U1109, MN3T, Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovascular Research Center, Massachusetts General Hospital [Boston], Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris sciences et lettres (PSL), Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH Aachen, Institute of Human Genetics, Universität Ulm - Ulm University [Ulm, Allemagne], German Center for Neurodegenerative Diseases, Compartimentation et dynamique cellulaires (CDC), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), REMAR-IVECAT Group, Germans Trias i Pujol Health Science Research Institute, Department of Genetics, Cell- and Immunobiology, Semmelweis University, School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Population Health and Immunity Division, Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, Faculty of Biological and Environmental Sciences [Helsinki], University of Helsinki, Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, National Cancer Center, Fund for Scientific Spearheads of the Ghent University Hospital, Concerted Research Actions from Ghent University, Stichting tegen Kanker, Kom Op Tegen Kanker, H2020/COST ME-HaD, Fund for Scientific Research Flanders (FWO), Krediet aan Navorsers from FWO, Universiteit Gent = Ghent University (UGENT), Instituto de Investigacion Sanitaria del Hospital de la Princesa, Hospital Universitario de La Princesa, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Helmholtz Zentrum München = German Research Center for Environmental Health, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Van Deun J., Mestdagh P., Agostinis P., Akay O., Anand S., Anckaert J., Martinez Z.A., Baetens T., Beghein E., Bertier L., Berx G., Boere J., Boukouris S., Bremer M., Buschmann D., Byrd J.B., Casert C., Cheng L., Cmoch A., Daveloose D., De Smedt E., Demirsoy S., Depoorter V., Dhondt B., Driedonks T.A.P., Dudek A., Elsharawy A., Floris I., Foers A.D., Gartner K., Garg A.D., Geeurickx E., Gettemans J., Ghazavi F., Giebel B., Kormelink T.G., Hancock G., Helsmoortel H., Hill A.F., Hyenne V., Kalra H., Kim D., Kowal J., Kraemer S., Leidinger P., Leonelli C., Liang Y., Lippens L., Liu S., Lo Cicero A., Martin S., Mathivanan S., Mathiyalagan P., Matusek T., Milani G., Monguio-Tortajada M., Mus L.M., Muth D.C., Nemeth A., Nolte-'T Hoen E.N.M., O'Driscoll L., Palmulli R., Pfaffl M.W., Primdal-Bengtson B., Romano E., Rousseau Q., Sahoo S., Sampaio N., Samuel M., Scicluna B., Soen B., Steels A., Swinnen J.V., Takatalo M., Thaminy S., Thery C., Tulkens J., Van Audenhove I., Van Der Grein S., Van Goethem A., Van Herwijnen M.J., Van Niel G., Van Roy N., Van Vliet A.R., Vandamme N., Vanhauwaert S., Vergauwen G., Verweij F., Wallaert A., Wauben M., Witwer K.W., Zonneveld M.I., De Wever O., Vandesompele J., Hendrix A., Ghent University [Belgium] (UGENT), Université Catholique de Louvain, Technical University of Munich (TUM), Physiologie des Adaptations Nutritionnelles [UMR_A1280] (PhAN), University of Ottawa [Ottawa] (uOttawa), Walter and Eliza Hall Institute of Medical Research (WEHI), Institut Curie-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), PSL Research University (PSL), Centre National de la Recherche Scientifique (CNRS)-Institut Curie-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), and Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)

Gerald M. Mkoji, Ittiprasert Wannaporn, Xiao-Jun Wu, Julia B. Carleton, Gloria I. Giraldo-Calderón, Matty Knight, Catherine S. Jones, Anthony T. Papenfuss, Elio Hideo Baba, Brian J. Raney, Richard M. Cripps, Christine Coustau, Martin T. Swain, René Feyereisen, Judith E. Humphries, Nithya Raghavan, Kathryn M. Ryan, Céline Cosseau, Karl F. Hoffmann, Michael S. Blouin, Edwin J. Routledge, TyAnna L. Lovato, Min Zhao, Olga Baron, Fabiano Sviatopolk-Mirsky Pais, Mikkel Christensens, Sandra W. Clifton, Leonid L. Moroz, Maria G. Castillo, Damian L. Trujillo, Donald P. McManus, Emanuela V. Volpi, Liana K. Jannotti-Passos, Scott P Lawton, Joanna M. Bridger, Yesid Cuesta-Astroz, Eric S. Loker, David Duval, Fernanda Ludolf, Bronwyn Rotgans, Mónica Medina, Di Liang, Benjamin Gourbal, Izinara C Rosse, Catrina Fronick, Sarah K. Buddenborg, Roberta Lima Caldeira, Umar Niazi, Aurélie Kapusta, Christoph Grunau, Scott F. Cummins, Katherine M. Buckley, Milind Misra, Matheus de Souza Gomes, LaDeana W. Hillier, Iain W. Chalmers, Guillaume Mitta, Scott J. Emrich, Kathrin K. Geyer, Wander de Jesus Jeremias, Larissa L. S. Scholte, Laurence Rodrigues do Amaral, Juliana G Assis, Jacob A. Tennessen, Emmanuel A. Pila, Patrick C. Hanington, Andrew M. Shedlock, Wesley C. Warren, Chris Botka, Sandra Grossi Gava, Coen M. Adema, Janeth J. Pena, Satwant Kaur, Chad Tomlinson, Richard Galinier, Michelle A. Gordy, Bishoy Kamel, Guilherme Oliveira, Anne E. Lockyer, Jonathan P. Rast, Andrea B. Kohn, Daniel Lawson, Richard K. Wilson, Patrick Minx, Bryony C. Bonning, Peter C. FitzGerald, Christopher J. Bayne, Omar dos Santos Carvalho, Monica Munoz-Torres, Tianfang Wang, David Rollinson, Vince Magrini, Kyle K. Biggar, Titouan Quelais, Leslie R. Noble, Utibe Bickham-Wright, Francislon Silva de Oliveira, Cédric Feschotte, Daniel J. Jackson, Joris M. Koene, Michael J. Montague, Anthony J. Walker, Lucinda Fulton, Daniel S.T. Hughes, Susan Jobling, Rob Peace, Halime D. Arican-Goktas, Nathalie Dinguirard, Timothy P. Yoshino, Mohammed Yusuf, Cesar E. Montelongo, Michael E. Geusz, Sijun Liu, Si-Ming Zhang, Kenneth B. Storey, Leon di Stephano, Yanin Limpanont, Center for Evolutionary and theoretical Immunology, Biology, The University of New Mexico [Albuquerque], The McDonnell Genome Institute (MGI), Washington University in St Louis, INSTITUTE OF BIOLOGICAL AND ENVIRONMENTAL SCIENCES, University of Aberdeen, Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty, George Washington University (GW), Division of Science & Mathematics, University of the District of Columbia, Fiocruz Minas - René Rachou Research Center / Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), sans affiliation, Biology Department, Medical University of South Carolina [Charleston] (MUSC), Laboratory of Bioinformatics and Molecular Analysis, Federal University of Uberlândia [Uberlândia] (UFU), Department of Life Sciences, College of Health and Life Sciences, Brunel University London [Uxbridge], Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Department of Integrative Biology, Oregon State University (OSU), Department of Pathobiological Sciences, University of Wisconsin-Madison, Institute of Biochemisty and Department of Biology, Carleton University, Iowa State University (ISU), Department of Information Technology, Harvard Medical School, Harvard Medical School [Boston] (HMS), Sunnybrook Health Sciences Centre, Department of Immunology, University of Toronto, Department of Human Genetics [Salt Lake City], University of Utah, Biology, New Mexico State University, New Mexico State University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, EMBL-EBI, Wellcome Genome Campus, Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, Health and Education, University of the Sunshine Coast, The Walter and Eliza Hall Institute for Medical Research (WEHI), Genomics and Bioinformatics Core Facility, University of Notre Dame [Indiana] (UND), Department of Plant and Environmental Sciences [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Genome Analysis Unit, National Cancer Institute, National Institutes of Health [Bethesda] (NIH), Biological Sciences, Bowling Green State University, Bowling Green State University, IBERS, Institute of Biological, Environmental and Rural Sciences, Biotechnology and Biological Sciences Research Council, Department of Public Health Sciences, University of Alberta, University of Alberta, Department of Biology, Lawrence University, Lawrence University, Courant Research Centre Geobiology, Georg-August University of Göttingen, Georg-August-University [Göttingen], Institute of Environment, Health & Societies, Environment and Health Theme, Brunel University London, Brunel University London, Department of Biology, Pennsylvania State University (Penn State), Penn State System-Penn State System, Faculteit der Aard- en Levenswetenschappen, Vrije Universiteit, Vrije Universiteit Amsterdam [Amsterdam] (VU), The Whitney Laboratory for Marine Bioscience, University of Florida, University of Florida [Gainesville], Molecular Parasitology Laboratory, Kingston University, Kingston University, Faculty of Science, Health, Education and Engineering (USC), Molecular Parasitology Unit, Queensland Institute of Medical Research, Penn State System, Kenya Medical Research Institute (KEMRI), Department of Neuroscience (DEPARTMENT OF NEUROSCIENCE), University of Pennsylvania [Philadelphia], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli, Melanoma Research Fellow Peter MacCallum Cancer Centre, Institute for Genomics and Bioinformatics [Irvine], University of California [Irvine] (UCI), University of California-University of California, Parasites and Vectors Division, London Centre for Neglected Tropical Disease Research, Natural History Museum, Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster [London] (UOW), Molecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry, Sequence characterization of the Biomphalaria glabrata genome was funded by NIH-NHGRI grant HG003079 to R.K.W., McDonnell Genome Institute, Washington University School of Medicine. Biomphalaria glabrata and Schistosoma mansoni were provided to some participating labs by the NIAID Schistosomiasis Resource Center (Biomedical Research Institute, Rockville, MD) through NIH-NIAID Contract HHSN272201000005I for distribution through BEI Resources. C.M.A. and E.S.L. acknowledge NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). Publication costs were contributed equally by McDonnell Genome Institute, Washington University School of Medicine and the COBRE Center for Evolutionary and Theoretical Immunology (CETI) which is supported by NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). E.S.L. acknowledges NIH/NIAID ROI AI101438. J.M.B., H.D.A.-G and M.K. acknowledge NIH-NIAID R01-AI0634808. M.Y. acknowledges UK BBSRC (BB/H022597/1). G.O. acknowledges support from FAPEMIG (RED-00014-14, PPM-00189-13) and CNPq (304138/2014-2, 309312/2012-4). R.L.C. acknowledges CNPq (503275/2011-5). T.P.Y. acknowledges NIH/NIAID RO1AI015503. K.F.H. and M.T.S. acknowledge BBSRC (BB/K005448/1). B.G. acknowledges ANR JCJC INVIMORY (ANR-13-JSV7-0009). S.E. acknowledges NIAID contract HHSN272201400029C. J.M.K. acknowledges the Research Council for Earth and Life Sciences (A.L.W., 819.01.007) and the Netherlands Organization for Scientific Research (NWO). R.M.C. acknowledges NIH GM061738 and support from the American Heart Association, Southwest Affiliate (14GRNT20490250). D.T. acknowledges NIH R25 GM075149. C.F. acknowledges NIH R01-GM077582. D.J.J. acknowledges D.F.G. JA2108/1-2. M.de S.G. acknowledges CNPq 479890/2013-7. K.M.B. and J.P.R. acknowledge NSERC 312221 and CIHR MOP74667. C.S.J., L.R.N., S.J., E.J.R., S.K. and A.E.L. acknowledge NC3R GO900802/1. K.K.B. and K.B.S. acknowledge NSERC 315051 and 6793, respectively. M.B. and C.J.B. acknowledge NIH RO1-AI109134. C.J.B. acknowledges NIH AI016137 and AI111201. B.R. acknowledges NHGRI 4U41HG002371. P.C.H., M.A.G. and E.A.P. acknowledge NSERC 418540. O.L.B. and Ch.C. acknowledge ANR-12-EMMA-0007-01. S.F.C. acknowledges Australian Research Council FT110100990., We thank S. Newfeld for discussion of actin evolution, N. El Sayed and H. Tettelin for discussion of HSP annotation and expression. We acknowledge access to the Metafer microscopy system at the I. Robinson Research Complex, Harwell, Rutherford Appleton Laboratory, Oxon, UK (BBSRC Professorial Fellowship, grant number BB/H022597/1)., Washington University in Saint Louis (WUSTL), The George Washington University (GW), Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Florida [Gainesville] (UF), Animal Ecology, and Adema, Coen M.

Benoit Witkowski, Hans-Peter Fuehrer, Garib Das Thakur, Céline Barnadas, Djibrine Djalle, Michael Ramharter, Mindy Leelawong, Wasif Ali-Khan, Harald Noedl, Bouasy Hongvanthong, Mohammad Shafiul-Alam, Hypolite Muhindo-Mavoko, Abdillahi Mohamed Hassan, Judith Straimer, Nimol Khim, Kigbafori D. Silué, Kaknika Loch, Barbara H. Stokes, Maria Dorina Bustos, Laura Berne, Dylan R. Pillai, Ayola A. Adegnika, Lin Hua Tang, Rotha Eam, Saorin Kim, Alioune Dieye, Mei Li, Carole E. Eboumbou-Moukoko, Lydie Canier, Marian Warsame, Didier Menard, David A. Fidock, Yap Boum, Lyndes Wini, Abdiqani Sheikh-Omar, Patrick Tshibangu-Wa-Tshibangu, Maman Laminou Ibrahim, Mohammad Jahirul-Karim, Malen Ken, Monique A. Dorkenoo, Sócrates Herrera, Odile Mercereau-Puijalon, Lise Musset, Valentine Duru, Eric Legrand, Maniphone Khanthavong, Pascal Ringwald, Bruno Pradines, Sandrine Houzé, Rachida Tahar, Olukemi K. Amodu, Johann Beghain, Sandie Menard, Liwang Cui, Colin J. Sutherland, Jun Hu Chen, Kesara Na-Bangchang, Khin Lin, Michael Nambozi, Rithea Leang, Jean Christophe Barale, Milijaona Randrianarivelojosia, Marcus V. G. Lacerda, Sophy Chy, Frédéric Ariey, Jean-Bosco Ouédraogo, Isabelle Morlais, Maria de Fátima Ferreira-da-Cruz, Lubin Jiang, Christophe Rogier, Jun Cao, Peter G. Kremsner, Bui Quang-Phuc, Inès Vigan-Womas, Din Syafruddin, Jetsumon Sattabongkot, Shigeyuki Kano, Abebe A. Fola, Louis Collet, Karamoko Niaré, Thierry Fandeur, Sedigheh Zakeri, Sodiomon B. Sirima, Antoine Berry, Jean Baptiste Mazarati, Fe Espino, Ghulam Rahim-Awab, Chanra Khean, Offianan Andre Toure, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Génétique et Génomique des Insectes vecteurs, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Centre de Recherche Médicale de Lambaréné, Albert Schweitzer, Leiden University Medical Center (LUMC), Universiteit Leiden, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), University of Ibadan, Nangarhar University, Mahidol University [Bangkok], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Papua New Guinea Institute for Medical Research (PNGIMR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Mbarara University of Science and Technology [Mbarara] (MUST), Epicentre Ouganda [Mbarara] [Médecins Sans Frontières], Epicentre [Paris] [Médecins Sans Frontières], World Health Organization (WHO), country office for Thailand, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), JiangSu University, National Institute of Parasitic Diseases, Center for Disease Control, China, Centre Hospitalier de Mayotte, Pennsylvania State University (Penn State), Penn State System, Epidemiology and Disease Control division (EDCD), Ministry of Public Health [Nepal], Institut Pasteur de Dakar, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Institut Pasteur de Bangui, Université de Lomé [Togo], Université de Douala, Centre Pasteur du Cameroun, Research Institute for Tropical Medicine, Centre International de Recherches Médicales de Franceville (CIRMF), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), University of Gondar, Institute of Parasitology [Vienna], University of Veterinary Medicine, Vienna, World Health Organisation (WHO), country office for Somalia, Caucaseco scientific research center = Centro de Investigación Científica Caucaseco, National Center for Malariology, Parasitology and Entomology, Ministry of Health [Mozambique], Hôpital Bichat - Claude Bernard, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Directorate General of Health Services (DGHS), Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), National Center for Global Health and Medicine [Japan] (NCGM), Institut Pasteur du Laos, Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), National Center for Malaria Control, Parasitology and Entomology, Ministry of Health of Cambodgia, Henry M. Jackson Foundation for the Advancement of Military Medicine (HJM), U.S. Naval Medical Research, The Department of Medical Research (Upper Myanmar), Rwanda Biomedical Center (RBC), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé, Cameroun] (IRD [Cameroun]), Institut de Recherche pour le Développement (IRD), University of Kinshasa (UNIKIN), University of Antwerp (UA), Institut Pasteur de la Guyane, Thammasat University (TU), Tropical Diseases Research Center (TDRC), Université de Bamako, Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Medicines for Malaria Venture (MMV), Université de Genève = University of Geneva (UNIGE), Global Malaria Programme, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme, Institut Pasteur de Madagascar, Ministry of Health and Human Services [Somalia], Centre Suisse de Recherches Scientifiques en Cote d'Ivoire [Abidjan] (CSRS-CI), Université Félix Houphouët-Boigny (UFHB), Groupe de recherche action en santé (GRAS), London School of Hygiene and Tropical Medicine (LSHTM), University of Hasanuddin, Eijkman Institute for Molecular Biology [Jakarta], Institut Pasteur de Côte d'Ivoire, Ministry of Health and Medical Services, Institut Pasteur d'Iran, Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Microbiologie structurale - Structural Microbiology (Microb. Struc. (UMR_3528 / U-Pasteur_5)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Columbia University Irving Medical Center (CUIMC), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Supported by the Institut Pasteur Paris, Institut Pasteur International Division, Institut Pasteur Cambodia, and the World Health Organization, by a grant (ANR-10-LABX-62-IBEID) from the French Government Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases', a grant from Natixis Banques, a grant (R01I109023, to Dr. Fidock) from the National Institutes of Health, grants from the Fiocruz Fundação Oswaldo Cruz, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Fundação de Amparo à Pesquisa do Estado do Amazonas, the Brazilian National Council for Scientific and Technological Development, the Agence Nationale de la Recherche (13-BSV3-0018-01 and11-BSV7-009-01), the Austrian Federal Ministry of Science, Research, and Econo-my, the Calgary Laboratory Services, the Centre International de Recherches Médicales de Franceville, the European and Developing Countries Clinical Trials Partnership (CT-2004-31070-001), the Drugs for Neglected Diseases Initiative, the Else Kroener Fresenius Stiftung, the Holger Poehlmann Stiftung, the European Community African–European Research Initiative 'IDEA' (HEALTH-F3-2009-241642), the Fonds Wetenschappelijk Onderzoek, the Vlaamse Interuniversitaire Raad–Universitaire Ontwikkelingssamenwerking, the Belgian Technical Cooperation in Democratic Republic of Congo, the European Community Seventh Framework Program (FP7/2007-2013, 242095, and 223601), the European Commission (REGPOT-CT-2011-285837-STRONGER), the Ministère de la Santé Publique du Niger (Laboratoire National de Référence Résistance aux Antipaludiques), the Foundation of National Science and Technology Major Program (2012ZX10004-220), the French Ministry of Health (Institut National de Veille Sanitaire), the Global Fund to Fight AIDS, Tuberculosis and Malaria, the 5% Initiative program (French Ministry of Foreign Affairs, France Expertise Internationale, 12INI109), the Institut Pasteur de Madagascar, the Government of the Philippines, the Institut de Recherche pour le Développement, the Foundation des Treilles, the Délégation Générale pour l’Armement (PDH-2-NRBC-4-B1-402), the Institut Pasteur de Bangui, the International Society for Health Research and Training, the Malaria Research Initiative Bandarban, Vienna, International Centre for Diarrhoeal Disease Research, Bangladesh, the Médecins sans Frontières (Centre Opérationnel Paris, France), Medicines for Malaria Venture, the National Research Council of Thailand, the Thammasat University, the National Natural Science Foundation of China (81271870, 81361120405, and 81271863), the Natural Science Foundation of Jiangsu Province (BK20130114 and BK20150001), the Jiangsu Science and Technology Department (BM2015024), the National Institutes of Health (R01 AI11646601, AI109023, and ICEMR U19AI089702, U19AI089672), the Pasteur Institute of Iran, the Malaria Division of the Iranian Center for Diseases Management and Control, Public Health England (Malaria Reference Service Contract), the Government of Rwanda, the U.S. Department of Defense Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (P0463-14-N6), the Fogarty International Center of the National Institutes of Health training (D43 TW007393), the Mahidol-Oxford Research Unit, the Government of Japan (Science and Technology Agency, Agency for Medical Research and Development, Japan International Cooperation Agency, and Science and Technology Research Partnership for Sustainable Development), and the President’s Malaria Initiative of the U.S. Agency for International Development., The KARMA Consortium, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-13-BSV3-0018,MALARTRES,Résistance de Plasmodium aux antipaludiques de la famille des artémisinines(2013), ANR-13-BSV7-0009,NEBEDIV,Le rôle des ennemis naturels dans la diversité béta des arbres tropicaux(2013), European Project: CT-2004-31070-001,EDCCTP, European Project: HEALTH-F3-2009-24164,IDEA, European Project: FP7/2007-2013, 24209,FP7, European Project: FP7/2007-2013, 22360,FP7, European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009), European Project: 223601,EC:FP7:HEALTH,FP7-HEALTH-2007-B,MALVECBLOK(2009), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Fundação Oswaldo Cruz (FIOCRUZ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Centre International de Recherches Médicales de Franceville, Caucaseco scientific research center, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), National Center for Global Health and Medicine (NCGM), Instituto Leônidas e Maria Deane (ILMD), Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement [Yaoundé], Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Eijkman Institute for Molecular Biology, Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010), Van geertruyden, Jean-Pierre, and KARMA Consortium

Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Lea Goupille, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Faculté de médecine [Genève], Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), Leuven Cancer Institute [Leuven, Belgium] (LKI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Josep Carreras Leukaemia Research Institute (IJC), MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Queen Mary University of London (QMUL), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Peter MacCallum Cancer Center, Perelman School of Medicine, University of Pennsylvania, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales (CREFRE), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Leuven Cancer Institute (LKI), Leuven, Belgium, ToxAlim (ToxAlim), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université de Genève = University of Geneva (UNIGE), and 2018/Ligue Nationale de Lutte contre le Cancer C57799/A27964/Cancer Research UK (CRUK) Institut National Du Cancer (INCa)

Thimali Arumapperuma, Jinling Li, Bastian Hornung, Niccolay Madiedo Soler, Ethan D. Goddard-Borger, Nicolas Terrapon, Spencer J. Williams, The Walter and Eliza Hall Institute of Medical Research (WEHI), Architecture et fonction des macromolécules biologiques (AFMB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and University of Melbourne

Hoff, Leonardo Santos, Ravichandran, Naveen, Shinjo, Samuel Katsuyuki, Day, Jessica, Sen, Parikshit, Junior, Jucier Gonçalves, Lilleker, James B., Joshi, Mrudula, Agarwal, Vishwesh, Kardes, Sinan, Kim, Minchul, Milchert, Marcin, Makol, Ashima, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Parodis, Ioannis, Selva O'Callaghan, Albert, Nikiphorou, Elena, Tan, Ai Lyn, Chatterjee, Tulika, Cavagna, Lorenzo, Saavedra, Miguel A., Ziade, Nelly, Knitza, Johannes, Kuwana, Masataka, Nune, Arvind, Distler, Oliver, Cansu, Döndü Üsküdar, Traboco, Lisa, Wibowo, Suryo Angorro Kusumo, Tehozol, Erick Adrian Zamora, Serrano, Jorge Rojas, La Torre, Ignacio García-De, Wincup, Chris, Pauling, John D., Chinoy, Hector, Agarwal, Vikas, Aggarwal, Rohit, Gupta, Latika, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Hoff LS] School of Medicine, Universidade Potiguar (UnP), Natal, Brazil. [Ravichandran N] Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. [Shinjo SK, Junior JG] Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. [Day J] Department of Rheumatology, Royal Melbourne Hospital, Parkville, Australia. Walter and Eliza Hall Institute of Medical Research, Parkville, Australia. Department of Medical Biology, University of Melbourne, Parkville, Australia. [Sen P] Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, India. [O'Callaghan AS] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Heidi S. Feiler, Eric A. Collisson, Joel Greshock, Mary Ann Hardwicke, Elizabeth Purdom, Gordon B. Mills, Bryan T. Hennessy, Lakshmi Jakkula, Pete Smith, Yinghui Guan, James E. Korkola, John W. Park, Joe W. Gray, Nicholas J. Wang, William J. Gibb, Kurtis E. Bachman, Denise M. Wolf, Lyubomir T. Vassilev, Henrik Bengtsson, Kenneth Wood, Stephen C. Benz, Zhi Hu, Anguraj Sadanandam, Nora Bayani, François Pepin, Frances Tong, Terence P. Speed, Laura M. Heiser, Sam Ng, Steffen Durinck, Theodore C. Goldstein, Joshua M. Stuart, Wen-Lin Kuo, Richard M. Neve, Paul T. Spellman, Jessica Billig, David Haussler, Sophia Lewis, Safiyyah Ziyad, Richard Wooster, Andrea Dueregger, Pierre Neuvial, Laurence J. Marton, Life Science Division [LBNL Berkeley], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Department of Biomolecular Engineering, University of California [Santa Cruz] (UCSC), University of California-University of California, Center for Biomolecular Science and Engineering, Department of Statistics [Berkeley], University of California [Berkeley], Laboratoire Statistique et Génome (SG), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Department of Epidemiology and Biostatistics, University of California, San Francisco, University of California [San Francisco] (UCSF), Cytokinetics Inc, Oncology, Millenium Pharmaceuticals, Hoffmann-La Roche Ltd, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, The University of Texas M.D. Anderson Cancer Center [Houston], GlaxoSmithKline, Glaxo Smith Kline, Division of Hematology-Oncology, Progen Pharmaceuticals, The Walter and Eliza Hall Institute of Medical Research (WEHI), The Walter and Eliza Hall Institute of Medical Research, Howard Hughes Medical Institute [Santa Cruz] (HHMI), Center for Biomolecular Science & Engineering, Department of Computer Science [Alabama], University of Alabama [Tuscaloosa] (UA), University of California-University of California-Howard Hughes Medical Institute (HHMI), University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), University of California [Berkeley] (UC Berkeley), University of California [San Francisco] (UC San Francisco), F. Hoffmann-La Roche [Basel], and Howard Hughes Medical Institute (HHMI)-University of California [Santa Cruz] (UC Santa Cruz)

Manfred B. Lutz, Shafaqat Ali, Cindy Audiger, Stella E. Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez‐Grau, Lucila Giusiano, Gloria J. Godoy, Marion Heuer, Anne B. Krug, Christian H. K. Lehmann, Christian T. Mayer, Shalin H. Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke, University of Würzburg, Institute of Medical Microbiology and Hospital Hygiene (University of Düsseldorf), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University of Tübingen, University Medical Center of the Johannes Gutenberg-University Mainz, Newcastle University [Newcastle], Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universitätsklinikum Erlangen [Erlangen], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), University Hospital Erlangen = Uniklinikum Erlangen, Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Ludwig Maximilian University [Munich] (LMU), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris sciences et lettres (PSL), Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Eindhoven University of Technology [Eindhoven] (TU/e), University of Duisburg-Essen, and Dalod, Marc

Anthony A. Ruberto, Caitlin Bourke, Amélie Vantaux, Steven P. Maher, Aaron Jex, Benoit Witkowski, Georges Snounou, Ivo Mueller, Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), University of Georgia [USA], Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Infectious Diseases Models for Innovative Therapies (IDMIT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), This work was supported by the Agence Nationale de la Recherche (https://anr.fr, ANR-17-CE13-0025 to A.A.R, G.S., I.M.), the National Health and Medical Research Council of Australia (www.nhmrc.gov.au, NHMRC, 1092789 and 1134989 to I.M.), National Institute of Allergy and Infectious Diseases (www.nih.niaid.gov, 5U19AI129392 to I.M), and a NHMRC Principal Research Fellowship (www.nhmrc.gov.au, 1155075 to I.M)., ANR-17-CE13-0025,IMHyp,Recherches sur l'Hypnozoïte du Paludisme(2017), Snounou, Georges, and Recherches sur l'Hypnozoïte du Paludisme - - IMHyp2017 - ANR-17-CE13-0025 - AAPG2017 - VALID

Rhea J. Longley, Matthew J. Grigg, Kael Schoffer, Thomas Obadia, Stephanie Hyslop, Kim A. Piera, Narimane Nekkab, Ramin Mazhari, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Kevin Tetteh, Chris Drakeley, Chetan E. Chitnis, Julie Healer, Wai-Hong Tham, Jetsumon Sattabongkot, Michael T. White, Daniel J. Cooper, Giri S. Rajahram, Bridget E. Barber, Timothy William, Nicholas M. Anstey, Ivo Mueller, The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Charles Darwin University [Australia], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Epidémiologie et Analyse des Maladies Infectieuses - Infectious Disease Epidemiology and Analytics, Ehime University [Matsuyama, Japon], RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), London School of Hygiene and Tropical Medicine (LSHTM), Biologie de Plasmodium et Vaccins - Malaria Parasite Biology and Vaccines, Mahidol University [Bangkok], University of Cambridge [UK] (CAM), Hospital Queen Elizabeth II [Kota Kinabalu, Sabah, Malaysia], Infectious Diseases Society Kota Kinabalu Sabah [Malaysia], Gleneagles Hospital [Kota Kinabalu, Sabah, Malaysia], WEHI Innovation Fund (R.L., I.M.). Clinical Trials Funding: Malaysian Ministry of Health (grant number BP00500420), the Asia Pacific Malaria Elimination Network (108-07), and the Australian National Health and Medical Research Council (NHMRC, 1037304, 1045156, 115680). NHMRC Fellowships to N.M.A. #1135820, M.J.G. #1138860, and R.L. #1173210. NHMRC grants #1092789, #1134989, #1132975 and #1043345 (I.M.). M.J.G. was also supported by the Australian Centre for International Agricultural Research (Grant# LS-2019-116)., Tham, Wai-Hong [0000-0001-7950-8699], and Apollo - University of Cambridge Repository

Vicki Athanasopoulos, Todor Arsov, Matthew C. Cook, Sui Rong Wayne Chen, Peter J. Schwartz, Ruiwu Wang, Deborah DiSilvestre, Hariharan Raju, David A Wallace, Richard Redon, Marcin Adamski, Helene Halkjær Jensen, Ivy E. Dick, Antony Kaspi, Melanie Bahlo, Matthew A. Field, Jinhong Wei, Lia Crotti, Michael Toft Overgaard, Mette Nyegaard, Haloom Rafehi, Bárbara B Ribeiro de Oliveira-Mendes, Carola G. Vinuesa, Yafei Zhang, Flavien Charpentier, Isabelle Baró, Malene Brohus, Aalborg University [Denmark] (AAU), Australian National University (ANU), Columbia University Irving Medical Center (CUIMC), Aarhus University [Aarhus], Istituto Auxologico Italiano, Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Macquarie University [Sydney], University of Maryland School of Medicine, University of Maryland System, University of Calgary, The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Brohus, M, Arsov, T, Wallace, D, Jensen, H, Nyegaard, M, Crotti, L, Adamski, M, Zhang, Y, Field, M, Athanasopoulos, V, Baró, I, Ribeiro de Oliveira-Mendes, B, Redon, R, Charpentier, F, Raju, H, Disilvestre, D, Wei, J, Wang, R, Rafehi, H, Kaspi, A, Bahlo, M, Dick, I, Chen, S, Cook, M, Vinuesa, C, Overgaard, M, and Schwartz, P

Thomas, Obadia, Narimane, Nekkab, Leanne J, Robinson, Chris, Drakeley, Ivo, Mueller, Michael T, White, Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris] (IP), Epidémiologie et Analyse des Maladies Infectieuses - Infectious Disease Epidemiology and Analytics, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), The Walter and Eliza Hall Institute of Medical Research (WEHI), Burnet Institute [Melbourne, Victoria], University of Melbourne, London School of Hygiene and Tropical Medicine (LSHTM), This work is supported by the Bill and Melinda Gates Foundation grants (INV009103 & VISPA INV024368) and NHMRC grants (GNT1102297 & GNT1171795) and is part of the International Centers of Excellence for Malaria Research program 'Understanding, tracking and eliminating malaria transmission in the Asia–Pacific Region,' funded by the National Institutes of Health, MD, US (grant 1U19AI129392-01). IM is supported by an NHMRC Principal Research Fellowship (GNT1155075). MTW is supported by the Agence Nationale de la Recherche Investissement d’Avenir Programme, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (ANR-10-LABX-62-IBEID) and INCEPTION program (ANR-16-CONV-0005). LJR is supported by an NHMRC Career Development Fellowship (GNT1161627)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris], and Institut Pasteur [Paris]-Université Paris Cité (UPC)

Nicolas Jacquelot, Cyril Seillet, Eric Vivier, Gabrielle T. Belz, University Health Network, Princess Margaret Cancer Centre [Toronto, Canada], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Innate Pharma, Hôpital de la Timone [CHU - APHM] (TIMONE), University of Queensland - The Diamantina Institute, University of Queensland [Brisbane], and ANR-17-RHUS-0007,PIONEER,Precision Immuno-Oncology for advanced Non small cell lung cancer patients with PD-1 ICI Resistance(2017)

Andrew H. Wei, Kevin Tran, Kristin K. Brown, Fiona C. Brown, Caitlin L. Rowe, Tatiana Cañeque, Ali Motazedian, Sebastian Müller, Giovanna Pomilio, Raphaël Rodriguez, Andrew G. Cox, Kate McArthur, Mathilde Poplineau, Marian L. Burr, Enid Y.N. Lam, Sylvain Garciaz, Mark A. Dawson, Lorey K. Smith, Brian Liddicoat, Georg Ramm, Estelle Duprez, Kah Lok Chan, Yih-Chih Chan, Sarah-Jane Dawson, Andrew A Guirguis, James Anton Kuzich, Veronique Litalien, David C.S. Huang, Laura MacPherson, University of Melbourne, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Chimie biologique des membranes et ciblage thérapeutique (CBMCT - UMR 3666 / U1143), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Monash University [Melbourne], The Walter and Eliza Hall Institute of Medical Research (WEHI), and Duprez, Estelle

Pelleau, Stéphane, Woudenberg, Tom, Rosado, Jason, Donnadieu, Françoise, Garcia, Laura, Obadia, Thomas, Gardais, Soazic, Elgharbawy, Yasmine, Velay, Aurelie, Gonzalez, Maria, Nizou, Jacques Yves, Khelil, Nizar, Zannis, Konstantinos, Cockram, Charlotte, Merkling, Sarah Hélène, Meola, Annalisa, Kerneis, Solen, Terrier, Benjamin, de Seze, Jerome, Planas, Delphine, Schwartz, Olivier, Dejardin, François, Petres, Stéphane, von Platen, Cassandre, Pellerin, Sandrine Fernandes, Arowas, Laurence, de Facci, Louise Perrin, Duffy, Darragh, Cheallaigh, Clíona Ní, Dunne, Jean, Conlon, Niall, Townsend, Liam, Duong, Veasna, Auerswald, Heidi, Pinaud, Laurie, Tondeur, Laura, Backovic, Marija, Hoen, Bruno, Fontanet, Arnaud, Mueller, Ivo, Fafi-Kremer, Samira, Bruel, Timothée, White, Michael, Epidémiologie et Analyse des Maladies Infectieuses - Infectious Disease Epidemiology and Analytics, Institut Pasteur [Paris] (IP), Malaria : parasites et hôtes - Malaria : parasites and hosts, Santé publique : épidémiologie & sciences de l'information biomédicale (ED 393), Sorbonne Université (SU), Département de Biologie Computationnelle - Department of Computational Biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Strasbourg, Institut Mutualiste de Montsouris (IMM), Régulation spatiale des Génomes - Spatial Regulation of Genomes, Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Virologie Structurale - Structural Virology, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Université de Paris, Paris, France, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Virus et Immunité - Virus and immunity (CNRS-UMR3569), Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform (PPR), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Immunologie Translationnelle - Translational Immunology lab, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Trinity College Dublin, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Direction de la recherche médicale de l'Institut Pasteur, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Vaccine Research Institute [Créteil, France] (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), This work was supported by the European Research Council (MultiSeroSurv ERC Starting Grant 852373, MW), l’Agence Nationale de la Recherche and Fondation pour la Recherche Médicale (CorPopImm, MW), and the Institut Pasteur International Network (CoronaSeroSurv, MW). JR was supported by the Pasteur Paris University (PPU) International PhD Program. CC was supported by the European Research Council 771813. MB, AL and HA were supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur. HA is supported by Centre for International Migration and Development. NC and CNC are part-funded by a Science Foundation Ireland (SFI) grant, Grant Code 20/SPP/3685. LT has been awarded the Irish ClinicalAcademic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z), the Health Service Executive, National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland (https://icatprogramme.org/). MB and AM were supported by Institut Pasteur TaskForce funding (TooLab project). IM is supported by a NHMRC Principal Research Fellowship. SFK lab is funded by Strasbourg University Hospitals (SeroCoV-HUS, PRI 7782), the Agence Nationale de la Recherche (ANR-18-CE17-0028), Laboratoire d'Excellence TRANSPLANTEX (ANR-11-LABX-0070_TRANSPLANTEX), and Institut National de la Santé et de la Recherche Médicale (UMR_S1109)., ANR-20-COVI-0052,CorPopImm,Évaluer l'immunité contre SARS-CoV-2 à l'échelle de la population grâce aux tests sérologiques(2020), ANR-18-CE17-0028,HuMABK,Les anticorps monoclonaux humains : une Nouvelle approche thérapeutique contre l'infection par le virus BK et les maladies associées(2018), ANR-11-LABX-0070,TRANSPLANTEX,Nouveaux loci d'histocompatibilité/biomarqueurs en transplantation humaine: de la découverte à l'app(2011), European Project: 852373,ERC-2019-STG,MultiSeroSurv(2020), European Project: 771813,ERC-2017-COG,SynarchiC(2018), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Virus et Immunité - Virus and immunity, Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM), HESAM Université (HESAM), Vaccine Research Institute (VRI), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)

Hui Jing Lim, Jacinta M. Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey Y.W. Mak, Abderrahman Hachani, Regan J. Anderson, Gavin F. Painter, Jesse Goyette, Shanika L. Amarasinghe, Matthew E. Ritchie, Antoine Roquilly, David P. Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A. Villadangos, Hamish E.G. McWilliam, KERANDEL-DION, Céline, University of Melbourne, Monash University [Clayton], University of New South Wales [Sydney] (UNSW), University of Queensland [Brisbane], Victoria University of Wellington, The Walter and Eliza Hall Institute of Medical Research (WEHI), Centre hospitalier universitaire de Nantes (CHU Nantes), Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis (U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), and Cardiff University

Lenore L. Carias, Benoit Witkowski, Saorin Kim, Christopher L. King, Camille Roesch, Nimol Khim, Ivo Mueller, Chetan E. Chitnis, Jean Popovici, Amélie Vantaux, Malaria Molecular Epidemiology, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Malaria Translational Research Unit (MTRU), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur [Paris], Case Western Reserve University [Cleveland], Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Louis Stokes Cleveland Veterans Affairs Medical Center, This work was supported by the International Centers of Excellence for Malaria Research program from the National Institutes of Health, grant 1U19AI129392-01., Malaria Molecular Epidemiology (MMEU), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur [Paris] (IP), and Institut Pasteur [Paris] (IP)

Daveu, Romain, Hervet, Caroline, Sigrist, Louane, Sassera, Davide, Jex, Aaron, Labadie, Karine, Aury, Jean-Marc, Plantard, Olivier, Rispe, Claude, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani' = Department of Biology and Biotechnology [Univ di Pavia] (DBB UNIPV), Università degli Studi di Pavia = University of Pavia (UNIPV), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Génomique métabolique (UMR 8030), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Genoscope, the Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA) and France Génomique (ANR-10-INBS-09-08), by the Italian Ministry of Education, University and Research (MIUR): Dipartimenti di Eccellenza Program (2018–2022) – Dept. of Biology and Biotechnology 'L. Spallanzani', University of Pavia (to D.S.), and by a grant from the Institut Carnot France Futur Elevage (XENOBIOTICK project)., Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dipartimento di Biologia e Biotecnologie ‘Lazzaro Spallanzani’, University of Pavia, University of Pavia, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)

Ariel Munitz, Kylie Luong, Andrew N. J. McKenzie, Jaring Schreuder, Wei Shi, Minyu Wang, Sharon Grisaru-Tal, Melissa J. Davis, Paul S. Foster, Joseph A. Trapani, Bogoljub Ciric, Sean Macdonald, Kevin Y. T. Thia, Soroor Hediyeh-Zadeh, Cynthia Louis, Ian P. Wicks, Stephen L. Nutt, Qiutong Huang, Jonathan Cebon, Shengbo Zhang, Daniel H.D. Gray, Paul J Neeson, Andreas Behren, Philip M. Hansbro, Cyril Seillet, Michael Chopin, Nicolas Jacquelot, Viktor Umansky, Angela Pizzolla, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Mary J Camilleri, Tristan Molden-Hauer, Yang Liao, Eric Vivier, Carolyn A. de Graaf, Gabrielle T. Belz, DUMENIL, Anita, The Walter and Eliza Hall Institute of Medical Research (WEHI), Princess Margaret Cancer Centre [Toronto, Canada], University of Melbourne, Peter MacCallum Cancer Centre [Melbourne, Australie], Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia], La Trobe University, Tel Aviv University (TAU), University of Queensland [Brisbane], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Ruprecht-Karls-University [Heidelberg, Germany], Jefferson (Philadelphia University + Thomas Jefferson University), University of Newcastle [Australia] (UoN), Centenary Institute [Sidney], The University of Sidney, University of Technology Sydney (UTS), MRC Laboratory of Molecular Biology [Cambridge, UK] (LMB), University of Cambridge [UK] (CAM)-Medical Research Council, Ludwig Institute for Cancer Research, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Innate Pharma, Hôpital de la Timone [CHU - APHM] (TIMONE), and University of Newcastle [Callaghan, Australia] (UoN)

Nekkab, Narimane, Lana, Raquel, Lacerda, Marcus, Obadia, Thomas, Siqueira, André, Monteiro, Wuelton, Villela, Daniel, Mueller, Ivo, White, Michael, Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris] (IP), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Universidade do Estado do Amazonas (UEA), The Walter and Eliza Hall Institute of Medical Research (WEHI), NN, MW, DV, and RL received funding from the Medicines for Malaria Venture (https://www.mmv.org/). NN has been in part supported by the Pasteur-Roux-Cantarini Fellowship by Institut Pasteur (https://research.pasteur.fr/en/call/pasteur-roux-cantarini-fellowship_call-for-application_2019-autumn-session/). NN, IM, and MW are supported by the Supporting Preparedness in the Asia-Pacific Region through Knowledge (SPARK) project under the ASEAN-Pacific Infectious Disease and Response program (APIDDaR) (https://www.spark.edu.au/). IM is supported by NHMRC Principal Research Fellowship (GNT1155075) (https://www.nhmrc.gov.au/funding/find-funding/research-fellowships). DV is a CNPq/Brazil research fellow (https://www.gov.br/cnpq/pt-br). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., and The authors would like thank Penny Grewal Daumerie, Elodie Jambert, Melanie Larson, Gonzalo Domingo, and Alexandre Menezes for their valued contributions, support, and fruitful discussions.

Peter G. Stanton, Lee B. Smith, Julien M. D. Legrand, Giuseppe Infusini, Frédéric Chalmel, Diane Rebourcet, Andrew I. Webb, Raouda Sgaier, Laura F. Dagley, Adrian Pilatz, Robin M. Hobbs, Wolfgang Weidner, Liza O'Donnell, Robert I McLachlan, Thorsten Diemer, Daniela Fietz, Peter J. O'Shaughnessy, Hudson Institute of Medical Research [Clayton], University of Newcastle [Australia] (UoN), The Walter and Eliza Hall Institute of Medical Research (WEHI), Justus-Liebig-Universität Gießen (JLU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Edinburgh, BB/J015105/1, Biotechnology and Biological Sciences Research Council, Deutsche Forschungsgemeinschaft, Chard-Hutchinson, Xavier, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and University of Newcastle [Callaghan, Australia] (UoN)

Rosado, Jason, White, Michael T., Longley, Rhea J., Lacerda, Marcus, Monteiro, Wuelton, Brewster, Jessica, Sattabongkot, Jetsumon, Guzman-Guzman, Mitchel, Llanos-Cuentas, Alejandro, Vinetz, Joseph M., Gamboa, Dionicia, Mueller, Ivo, Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Santé publique : épidémiologie & sciences de l'information biomédicale (ED 393), Sorbonne Université (SU), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Mahidol University [Bangkok], Universidad Peruana Cayetano Heredia (UPCH), Yale University School of Medicine, This work was supported by National Health and Medical Research Council Australia grants 1092789, 1134989 and 1043345 to IM (https://www.nhmrc.gov.au/), the Global Health Innovative Technology Fund grant T2015-142 to IM (https://www.ghitfund.org/), National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID) U19AI089681 to JMV (https://www.niaid.nih.gov). This work has been supported by FIND with funding from the Australian and British governments. The Brazilian team was partly funded by Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM (PAPAC 005/2019 and Pró-Estado). JR is supported by the Pasteur - Paris University (PPU) International PhD Program. RJL received the Page Betheras Award from WEHI to provide funding for technical support for this project during parental leave. RJL is supported by a NHMRC Early Career Investigator Fellowship (1173210). ML and WM are fellows of the Brazilian National Council for Scientific and Technological Development. MGG is supported by Training Grant 5D43TW007120 (https://www.fic.nih.gov)., Institut Pasteur [Paris] (IP), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), and Yale School of Medicine [New Haven, Connecticut] (YSM)

Michael J. Mlodzianoski, Carolyn A. de Graaf, Leonard C. Harrison, Christine R. Keenan, Naiara G. Bediaga, Hannah D. Coughlan, Thomas Boudier, Kelly L. Rogers, Timothy M. Johanson, Gaetano Naselli, Rhys S. Allan, Erin C. Lucas, Douglas J. Hilton, Gordon K. Smyth, Qike Wang, The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, Hal Sorbonne Université, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Thomas Obadia, Jetsumon Sattabongkot, Ingrid Felger, Wang Nguitragool, Andrea Kuehn, Wuelton Marcelo Monteiro, Ivo Mueller, Anne Cristine Gomes de Almeida, Lyndes Wini, Andreea Waltmann, Andrew Waleluma Darcy, Quique Bassat, Marcus V. G. Lacerda, Cristian Koepfli, Eline Kattenberg, Leanne J. Robinson, Patricia Rarau, Maria Ome-Kaius, James W. Kazura, The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, University of Notre Dame [Indiana] (UND), Mahidol University [Bangkok], Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Universidade do Estado do Amazonas (UEA), Universitat de Barcelona (UB), Papua New Guinea Institute for Medical Research (PNGIMR), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris], Case Western Reserve University [Cleveland], Ministry of Health and Medical Services [Solomon Islands], Centro de Investigação em Saúde de Manhiça [Maputo, Mozambique] (CISM), Institució Catalana de Recerca i Estudis Avançats (ICREA), Hospital Sant Joan de Déu [Barcelona], CIBER de Epidemiología y Salud Pública (CIBERESP), Swiss Tropical and Public Health Institute [Basel], This work was funded by the TransEPI Consortium/Bill and Melinda Gates Foundation (www.gatesfoundation.org, IM, OPP1034577), the Australian National Health and Medical Research Council (www.nhmrc.gov.au, IM, 1021544, 1092789), and NIH (www.nih.gov, JK, 1U19AI089686, IM, 1U19AI129392). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. CK was supported by a fellowship from the Swiss National Science Foundation (#P2BSP3_151880). LJR was supported by an NHMRC Early Career Fellowship #1016443 (www.nhmrc.gov.au). IM is supported by a NHMRC Senior Research Fellowship (www.nhmrc.gov.au). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya (https://cerca.cat/en/). CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID, www.aecid.es)., Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), and Institut Pasteur [Paris] (IP)

John B. Keven, Jason Rosado, Moses Laman, Cristian Koepfli, Ingrid Felger, Michelle Katusele, Lina Lorry, Daniela Rodriguez-Rodriguez, Natalie E. Hofmann, Manuel W Hetzel, Freya J. I. Fowkes, Elma Nate, Leanne J. Robinson, Alma Auwan, Mary Salib, Ivo Mueller, Maria Ome-Kaius, James W. Kazura, Stephan Karl, Desmond Gul, Archie C. A. Clements, Burnet Institute [Melbourne, Victoria], Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Papua New Guinea Institute of Medical Research (PNG-IMR), Michigan State University System, Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), University of Notre Dame [Indiana] (UND), The Walter and Eliza Hall Institute of Medical Research (WEHI), Case Western Reserve University [Cleveland], James Cook University (JCU), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Telethon KIDS Institute, The University of Western Australia (UWA), University of Melbourne, Monash University [Melbourne], This work was funded by WHO/Tropical Disease Research Program grant (WCCPRD4426109 2016/639607), NIH NIAID International Centres of Excellence in Malaria Research South West Pacific (U19 AI089686) and Asia Pacific (U19 AI129392-01) and NHMRC Australian Centre of Research Excellence for Malaria Elimination (ACREME GNT1134989). D.G. is supported by an Australian Government Research Training Program (RTP) Scholarship. M.K. is the recipient of a Wellcome Trust International Masters Fellowship. I.M. (GNT11155075), S.K. (GNT1141441) and L.J.R. (GNT1161627) are supported by NHMRC Fellowships., and Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Daniel M. Wall, Gabrielle T Belz, John J. Cole, Vuk Cerovic, Edward S Lee, Gérard Eberl, Natalie Papazian, Michio Tomura, Verena Kästele, David R. Withers, Carl S. Goodyear, Tom Cupedo, Simon Milling, Rose A. Maciewicz, Johannes U Mayer, Hematology, HUGOT, Bérengère, Institute of Infection, Immunity and Inflammation [Glasgow, UK], University of Glasgow, Albert Einstein College of Medicine [New York], Erasmus University Medical Center [Rotterdam] (Erasmus MC), The Walter and Eliza Hall Institute of Medical Research (WEHI), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Osaka Ohtani University [Osaka, Japan], Microenvironnement et Immunité - Microenvironment and Immunity, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Birmingham [Birmingham], V.K. was supported by the Versus Arthritis Rheumatoid Arthritis Pathogenesis Centre for Excellence (RACE) (grant number 20298). J.M. was supported by the Wellcome Trust 'Molecular Functions in Disease' Doctoral Training Programme. J.J.C. was supported by the GLAZgo Discovery Centre. V.C. was supported by a project grant from the Medical Research Council (MR/K021095/1)., RWTH Aachen University, and Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)

Viera Kovacova, Lisa K. Mahdi, Leïla Brulé Kopp, Menghang Huang, Florence Jacob, Xiaoxiao Zhang, Jane E. Parker, Isabel M. L. Saur, Kay Hofmann, Paul Schulze-Lefert, Ryohei Thomas Nakano, Takaki Maekawa, Dmitry Lapin, James M. Murphy, Jijie Chai, Max Planck Institute for Plant Breeding Research (MPIPZ), Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University [Beijing] (THU)-Tsinghua University [Beijing] (THU), Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]-Max Planck Institute for Plant Breeding Research (MPIPZ)-Universität zu Köln = University of Cologne, Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, The Walter and Eliza Hall Institute of Medical Research (WEHI), Institute for Genetics, German Research Foundation (DFG)SFB-1403-414786233University of Cologne Centre of Excellence in Plant Sciences National Natural Science Foundation of China (NSFC)31421001National Health and Medical Research Council of AustraliaUK Research & Innovation (UKRI)Medical Research Council UK (MRC)110575411729291124735IRIISS 9000587Victorian State Government Operational Infrastructure Support scheme Alexander von Humboldt Foundation, Universität zu Köln-Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]-Max Planck Institute for Plant Breeding Research (MPIPZ), and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Dubuisson, Agathe, Fahrner, Jean Eudes, Goubet, Anne Gaëlle, Terrisse, Safae A., Voisin, Nicolas, Bayard, Charles, Lofek, Sébastien, Drubay, Damien, Bredel, Delphine, Mouraud, Séverine, Susini, Sandrine, Cogdill, Alexandria P., Rebuffet, Lucas, Ballot, Elise, Jacquelot, Nicolas, Thomas de Montpreville, Vincent, Casiraghi, Odile, Radulescu, Camélia, Ferlicot, Sophie, Figueroa, David J., Yadavilli, Sapna, Waight, Jeremy D., Ballas, Marc S., Hoos, Axel X., Condamine, Thomas, Parier, Bastien, Gaudillat, Christophe, Routy, Bertrand, Ghiringhelli, François, Derosa, Lisa, Breuskin, Ingrid, Rouanne, Mathieu, André, Fabrice, Lebacle, Cédric, Baumert, Hervé, Wislez, Marie, Fadel, Élie, Cremer, Isabelle, Albiges, Laurence, Geoerger, Birgit, Scoazec, Jean Yves, Loriot, Yohann, Kroemer, Guido, Marabelle, Aurélien, Bonvalet, Mélodie, Zitvogel, Laurence, Immunologie des tumeurs et immunothérapie (UMR 1015), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), The University of Texas M.D. Anderson Cancer Center [Houston], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, The Walter and Eliza Hall Institute of Medical Research (WEHI), Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Département de médecine oncologique [Gustave Roussy], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], Direction de la recherche [Gustave Roussy], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Karolinska University Hospital [Stockholm], Chancellerie des Universités de Paris Agence Nationale de la Recherche, ANR Seerave Foundation Association pour la Recherche sur le Cancer, ARC ANR‐16‐RHUS‐0008 Ligue Contre le Cancer European Commission, EC Fondation pour la Recherche Médicale, FRM Institut National Du Cancer, INCa Institut Universitaire de France, IUF European Research Council, ERC Fondation Leducq RP170067 Association pour la Recherche sur le Cancer, ARC, LZ and GK were supported by the Ligue contre le Cancer (équipe labelisée), Agence Nationale de la Recherche (ANR) francogermanique ANR‐19‐CE15‐0029, ANR Projects blancs, ANR under the frame of E‐Rare‐2, the ERA‐Net for Research on Rare Diseases, Association pour la recherche sur le cancer (ARC), Bristol‐Myers Squibb Company (International Immuno‐Oncology Network), Cancéropôle Ile‐de‐France, Chancellerie des universités de Paris (Legs Poix), Fondation pour la Recherche Médicale (FRM), a donation by Elior, the European Commission (ArtForce), the European Research Council (ERC), Fondation Carrefour, Institut National du Cancer (INCa), Inserm (HTE), Institut Universitaire de France, LeDucq Foundation, the LabEx Immuno‐Oncology, the RHU Torino Lumière (ANR‐16‐RHUS‐0008), H2020 ONCOBIOME, the Seerave Foundation, the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), FHU CARE, Dassault, and Badinter Philantropia, and the Paris Alliance of Cancer Research Institutes (PACRI). AC is supported by the CPRIT Research Training Program (RP170067). JEF was supported by Transgene and AGG was supported by FRM. AM has been or is currently an investigator in clinical trials sponsored by BMS, MSD, GSK/Tesaro, Janssen, Roche/Genentech, Pfizer, Astra Zeneca (AZ), Amgen. AM has been or is currently a member of Clinical Trial Scientific Steering Committee for AZ and GSK. AM has been or is currently a member of the scientific advisory board of the following companies: Merck Serono, Novartis, BMS, Symphogen, Amgen, Tesaro/GSK, Pfizer, Astra Zeneca/Medimmune, Servier, Sanofi. AM has provided Scientific & Medical Consulting to the following companies: Roche, Sanofi. AM is a member of the Data Safety and Monitoring Board for the following trial NCT02423863 (TLR3 agonist, Oncovir). AM has received research funding and or drug supply for pre‐Clinical and clinical research projects from: BMS, Boehringer Ingelheim, Idera, MSD, Fondation MSD Avenir, SIRIC (INCa‐DGOS‐Inserm_12551)., ANR-16-RHUS-0008,LUMIERE,LUMIERE(2016), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)

Nimol Khim, Michael T. White, Leanne J. Robinson, Benoit Witkowski, Saorin Kim, Amélie Vantaux, Mirco Sandfort, Soazic Gardais, Anais Pepey, Dysoley Lek, Ivo Mueller, Thomas Obadia, Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris] (IP), Malaria Molecular Epidemiology (MMEU), Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia] (CNM), National Institute of Public Health [Phnom Penh, Cambodge], The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Burnet Institute [Melbourne, Victoria], This study is part of the International Centers of Excellence for Malaria Research programme 'Understanding, tracking and eliminating malaria transmission in the Asia–Pacific Region', funded by the National Institutes of Health, MD, US (grant 1U19AI129392-01) and received additional funding by NHMRC (Australia, GNT1092789). IM is supported by an NHMRC Principal Research Fellowship (GNT1155075). LJR is supported by an NHMRC Career Development Fellowship (GNT1161627). MS is part of the PhD programme of the doctoral school ED393 Pierre Louis de santé publique and supported by the Sorbonne Université (contract n°2695/2017). AP is supported by the Pasteur Institute International Network PhD fellowship programme 'Calmette & Yersin'., Institut Pasteur [Paris], Malaria Molecular Epidemiology, and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)