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The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong nonlinear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that kink formation entails a mixed spool-nematic ordering of double-stranded DNA or RNA in spherical capsids, consisting of an outer spool domain and an inner, twisted nematic domain. These findings explain the experimentally observed nematic domains in viral capsids and imply that nonlinear elasticity must be considered to predict the configurations and dynamics of double-stranded genomes in viruses, bacterial nucleoids or gene-delivery vehicles. The nonlinear elastic theory suggests that spool-nematic ordering is a general feature of strongly confined kinkable polymers.

Background: Transesophageal echocardiography (TEE) is mandatory before transvenous lead extraction (TLE), but its usefulness remains underestimated. This study aims to describe the broad range of TEE findings in TLE candidates, as well as their influence on procedure complexity, major complications (MCs) and long-term survival. Methods: Preoperative TEE was performed in 1191 patients undergoing TLE. Results: Lead thickening (OR = 1.536; p = 0.007), lead adhesion to heart structures (OR = 2.531; p < 0.001) and abnormally long lead loops (OR = 1.632; p = 0.006) increased the complexity of TLE. Vegetation-like masses on the lead (OR = 4.080; p = 0.44), lead thickening (OR = 2.389; p = 0.049) and lead adhesion to heart structures (OR = 6.341; p < 0.001) increased the rate of MCs. The presence of vegetations (HR = 7.254; p < 0.001) was the strongest predictor of death during a 1-year follow-up period. Conclusions: TEE before TLE provides a lot of important information for the operator. Apart from the visualization of possible vegetations, it can also detect various forms of lead-related scar tissue. Build-up of scar tissue and the presence of long lead loops are associated with increased complexity of the procedure and risk of MCs. Preoperative TEE performed outside the operating room may have an impact on the clinical decision-making process, such as transferring potentially more difficult patients to a more experienced center or having the procedure performed by the most experienced operator. Moreover, the presence of masses or vegetations on the leads significantly increases 1-year and all-cause mortality.

We present an experimental investigation of the formation stage of a collisionless shock when the flow velocity is aligned with an ambient magnetic field utilizing laser-driven, super-Alfvénic plasma flows. As the flows interact, electromagnetic streaming instabilities develop. Proton deflectometry is used to visualize these electromagnetic fluctuations indicating the development of the ion-Weibel instability and the nonresonant instability. Hybrid simulations also show growth of the nonresonant instability and suggest that it provides an efficient source of dissipation for a shock.

We study the rheology of bidisperse non-Brownian suspensions using particle-based simulation, mapping the viscosity as a function of the size ratio of the species, their relative abundance, and the overall solid content. The variation of the viscosity with applied stress exhibits shear-thickening phenomenology irrespective of composition, though the stress-dependent limiting solids fraction governing the viscosity and its divergence point are nonmonotonic in the mixing ratio. Contact force data demonstrate an asymmetric exchange in the dominant stress contribution from large-large to small-small particle contacts as the mixing ratio of the species evolves. Combining a prior model for shear thickening with one for composition-dependent jamming, we obtain a full description of the rheology of bidisperse non-Brownian suspensions capable of predicting effects such as the viscosity reduction observed upon adding small particles to a suspension of large particles.

The asymptotic scaling behavior of the Kuramoto model with finite populations has been notably elusive, despite comprehensive investigations employing both analytical and numerical methods. In this paper, we explore the Kuramoto model with "deterministic" sampling of natural frequencies, employing extensive numerical simulations and reporting the asymptotic values of the finite-size scaling exponents, which deviate significantly from the previously reported values in the literature. Additionally, we observe that these exponents are sensitive to the specifics of the sampling method. We discuss the origins of this variability through the self-consistent theory of entrained oscillators.

The Eshelby problem refers to the response of a two-dimensional elastic sheet to cutting away a circle, deforming it into an ellipse, and pushing it back. The resulting response is dominated by the so-called Eshelby kernel, which was derived for purely elastic (infinite) material, but has been employed extensively to model the redistribution of stress after plastic events in amorphous solids with finite boundaries. Here, we discuss and solve the Eshelby problem directly for amorphous solids, taking into account possible screening effects and realistic boundary conditions. We find major modifications compared to the classical Eshelby solution. These modifications are needed for modeling correctly the spatial responses to plastic events in amorphous solids.

Typical magnetic skyrmion is a string of inverted magnetization within a ferromagnet, protected by a sleeve of a vortexlike spin texture, such that its cross-section carries an integer topological charge. Some magnets form antiskyrmions, the antiparticle strings which carry an opposite topological charge. Here we demonstrate that topologically equivalent but purely electric antiskyrmion can exist in a ferroelectric material as well. In particular, our computer experiments reveal that the archetype ferroelectric, barium titanate, can host antiskyrmions at zero field. The polarization pattern around their cores reminds ring windings of decorative knots rather than the typical magnetic antiskyrmion texture. We show that the antiskyrmion of barium titanate has just 2-3 nm in diameter, a hexagonal cross section, and an exotic topological charge with doubled magnitude and opposite sign when compared to the standard skyrmion string.

Ultrafast laser radiation or beams of fast charged particles primarily excite the electronic system of a solid driving the target transiently out of thermal equilibrium. Apart from the nonequilibrium between the electrons and atoms, each subsystem may be far from equilibrium. From first principles, we derive the definition of various atomic temperatures applicable to electronically excited ensembles. It is shown that the definition of the kinetic temperature of atoms in the momentum subspace is unaffected by the excitation of the electronic system. When the electronic temperature differs from the atomic one, an expression for the configurational atomic temperature is proposed, applicable to the electronic-temperature-dependent interatomic potentials (such as ab initio molecular dynamics simulations). We study how the configurational temperature behaves during nonthermal phase transition, triggered by the evolution of the interatomic potential due to the electronic excitation. It is revealed that upon the ultrafast irradiation, the atomic system of a solid exists temporarily in a multitemperature state: separate equilibria in the momentum and configurational subspaces. Complete equilibration between the various atomic temperatures takes place at longer timescales, forming the energy equipartition. Based on these results, we propose a formulation of multitemperature heat transport equations.

The nuclear two-photon or double-gamma (2γ) decay is a second-order electromagnetic process whereby a nucleus in an excited state emits two gamma rays simultaneously. To be able to directly measure the 2γ decay rate in the low-energy regime below the electron-positron pair-creation threshold, we combined the isochronous mode of a storage ring with Schottky resonant cavities. The newly developed technique can be applied to isomers with excitation energies down to ∼100  keV and half-lives as short as ∼10  ms. The half-life for the 2γ decay of the first-excited 0^{+} state in bare ^{72}Ge ions was determined to be 23.9(6) ms, which strongly deviates from expectations.

Diffusive transport has implications for the long-term status of underground storage of hydrogen (H&#95;{2}) fuel and carbon dioxide (CO&#95;{2}), technologies which are being pursued to mitigate climate change and advance the energy transition. Once injected underground, CO&#95;{2} and H&#95;{2} will exist in multiphase fluid-water-rock systems. The partially soluble injected fluids can flow through the porous rock in a connected plume, become disconnected and trapped as ganglia surrounded by groundwater within the storage rock pore space, and also dissolve and migrate through the aqueous phase once dissolved. Recent analyses have focused on the concentration gradients induced by differing capillary pressure between fluid ganglia which can drive diffusive transport ("Ostwald ripening"). However, studies have neglected or excessively simplified important factors, namely the nonideality of gases under geologic conditions, the opposing equilibrium state of dissolved CO&#95;{2} and H&#95;{2} driven by the partial molar density of dissolved solutes, and entropic and thermodiffusive effects resulting from geothermal gradients. We conduct an analysis from thermodynamic first principles and use this to provide numerical estimates for CO&#95;{2} and H&#95;{2} at conditions relevant to underground storage reservoirs. We show that while diffusive transport in isothermal systems is upwards for both gases, as indicated by previous analysis, entropic contributions to the free energy are so significant as to cause a reversal in the direction of diffusive transport in systems with geothermal gradients. For CO&#95;{2}, even geothermal gradients less than 10^{∘}C/km (far less than typical gradients of 25^{∘}C/km) are sufficient to induce downwards diffusion at depths relevant to storage. Diffusive transport of H&#95;{2} is less affected but still reverses direction under typical gradients, e.g., 30^{∘}C/km, at a depth of 1000 m. This reversal occurs independent of the solute's thermophobicity or thermophilicity in aqueous solutions. The entropic contribution also modifies the magnitude of flux where geothermal gradients are present, with the largest diffusive fluxes estimated for CO&#95;{2} with a 30^{∘}C/km gradient, despite the higher diffusion coefficient of H&#95;{2}. We find a maximum flux on the order of 10^{-13} mol/(cm^{2}s) for CO&#95;{2} in the 30^{∘}C/km scenario; significantly lower than literature estimates for maximum convective fluxes in moderate to high permeability formations. Contrary to previous studies, we find that in diffusion and convection will likely work in concert-both driving CO&#95;{2} downwards, and both driving H&#95;{2} upwards-for conditions representative of their respective storage reservoirs.

We present the microscopic formulation of inclusion statistics, a counterpoint to exclusion statistics in which particles tend to coalesce more than ordinary bosons. We derive the microscopic occupation multiplicities of one-body quantum states and show that they factorize into a product of clusters of neighboring occupied states with enhanced statistical weights. Applying this statistics to a one-dimensional gas of particles in a harmonic well leads to a Calogero-like n-body inclusion spectrum with interesting physical properties.

The article analyzes publications considering motivation of plasma donors by factors related to ethical and socio-economic aspects. Their detailed analysis and systematical consideration in the work contributes into more effective informing of new potential donors, improving recruitment and retention of donors. The detailed analysis established among causes of negative beliefs and negative experiences regarding donorship such factors as increased risk of infectious diseases, decreased vitality, vaso-vagal reactions and reduced iron content. It is demonstrated that experienced plasma donors try to maintain practice of donorship in conditions of intensive life activity, often applying flexible approach to frequency of plasma donation. Their knowledge about contribution that their donation makes is key factor in continuing donation. However, the COVID-19 pandemic developed additional obstacles to donorship due to state preventive measures and increased personal health risks. In order to develop donorship policy during pandemic in the future, it is important to study changes in motivation of donors during pandemic.

The humanization of medical education is targeted at integration of humanitarian values and approaches into system of education of medical personnel to improve their professional and personal training. This process includes education in medical ethics, development of communication skills, stress management and implementation of humanitarian disciplines into the curriculum. The humanization contributes into formation of empathy, responsibility and professionalism in future physicians that helps to better understand and consider psychological, social and emotional needs of patients. The problems of including humanitarian sciences into medical education are associated with lack of systematic approach, adequate curricula and qualified lecturers. To optimize process, it is necessary to focus on education of ideals and beliefs, development of integrated curricula and enhancement of humanitarian component of education.

Stochastic processes have found numerous applications in science, as they are broadly used to model a variety of natural phenomena. Due to their intrinsic randomness and uncertainty, they are, however, difficult to characterize. Here, we introduce an unsupervised machine learning approach to determine the minimal set of parameters required to effectively describe the dynamics of a stochastic process. Our method builds upon an extended β-variational autoencoder architecture. By means of simulated data sets corresponding to paradigmatic diffusion models, we showcase its effectiveness in extracting the minimal relevant parameters that accurately describe these dynamics. Furthermore, the method enables the generation of new trajectories that faithfully replicate the expected stochastic behavior. Overall, our approach enables the autonomous discovery of unknown parameters describing stochastic processes, hence enhancing our comprehension of complex phenomena across various fields.

The article considers role and specifics of professional competencies of employees of medical public organizations providing vital medical and social services to vulnerable groups of population having no access to necessary care due to financial difficulties, geographical isolation, natural disasters and other causes. It is noted that employees of such organizations have unique set of professional competencies permitting them to effectively function in conditions of limited resources and unstable circumstances. The importance of interdisciplinary interaction, cultural competence, ethicality and legal awareness of employees.

With the original Bak-Tang-Wisenefeld (BTW) sandpile we uncover the 1/φ noise in the mechanism maintaining self-organized criticality (SOC)-the question raised together with the concept of SOC. The BTW sandpile and the phenomenon of SOC in general are built on the slow time scale at which the system is loaded and the fast time scale at which the stress is transported outward from overloaded locations. Exploring the dynamics of stress in the slow time in the BTW sandpile, we posit that it follows cycles of gradual stress accumulation that end up with an abrupt stress release and the drop of the system to subcritical state. As the system size grows, the intracycle dynamics exhibits the 1/φ-like spectrum that extends boundlessly and corresponds to the stress release within the critical state.

March's celebrated agent-based simulation model for organizational learning [J. G. March, Org. Sci. 2, 71 (1991)] has been extensively studied in recent decades. Yet the model has not been fully understood due to the lack of analytical solutions of the model. We simplify the March model to take an analytical approach using master equations. We then derive exact solutions for some of the simplest yet nontrivial cases, and perform numerical estimation of master equations for more complicated cases. Both analytical and numerical results are in good agreement with agent-based simulations. These results are also compared to those of the original March model. Our approach enables us to rigorously understand the results of the simplified model as well as the original model, to a large extent.

The application of mathematical modeling approaches based on factual demand of the population of territories in setting of medical and technical tasks makes it possible to significantly optimize costs of construction and equipping primary health care objects. This is confirmed by both corresponding calculations and results of analysis. This operation is oriented both on structural divisions of regional executive authorities responsible for setting of medical and technical tasks, and on investment companies implementing projects in health care.

Incorporating additive noise components to an ensemble of McCulloch-Pitts neurons can enhance the information representation of the input, asymptotically approaching the average firing probability for large enough ensembles. We further multiply the input by the average firing probability to control the higher probability of self-gating, thereby forming a unified noise-boosted activation model with learnable noise-related hyperparameters. This gating strategy plays a crucial role in improving the performance of neural networks, as evidenced by the optimization of the autoencoder loss at nonzero optimal-noise-scaling hyperparameters, a phenomenon termed self-gating stochastic resonance. Experiments with designed autoencoders using noise-boosted activation functions demonstrate the potential applications of the self-gating stochastic resonance effect in the field of unsupervised learning.

Microresonator frequency comb generation from Kerr solitons has become a cutting edge technology, but challenges remain in creating, maintaining, and controlling the solitons. Pump modulation and dual pumping are promising techniques for meeting these challenges. Here we derive the equation of motion of solitons interacting with a modulated pump in the framework of synchronization theory. It implies that the soliton repetition rate locks to the modulation frequency whenever the latter is within a locking range of frequencies around an integer multiple of the free spectral range of the microresonator. We calculate explicitly, numerically, and in perturbation theory the width of the locking range as a function of the amplitude and frequency of the pump and the modulation phase. We show that a highly red-detuned, strong pump that is amplitude-modulated provides the best conditions for entrainment, and that the width of the locking range is proportional to the square of the modulation frequency, limiting the effectiveness of RF modulation as an entrainment method.

This study overviews and extends a recently developed stochastic finite-temperature Kohn-Sham density functional theory to study warm dense matter using Langevin dynamics, specifically under periodic boundary conditions. The method's algorithmic complexity exhibits nearly linear scaling with system size and is inversely proportional to the temperature. Additionally, a linear-scaling stochastic approach is introduced to assess the Kubo-Greenwood conductivity, demonstrating exceptional stability for dc conductivity. Utilizing the developed tools, we investigate the equation of state, radial distribution, and electronic conductivity of hydrogen at a temperature of 30 000 K. As for the radial distribution functions, we reveal a transition of hydrogen from gaslike to liquidlike behavior as its density exceeds 4g/cm^{3}. As for the electronic conductivity as a function of the density, we identified a remarkable isosbestic point at frequencies around 7 eV, which may be an additional signature of a gas-liquid transition in hydrogen at 30 000 K.

Polymer physics models suggest that chromatin spontaneously folds into loop networks with transcription units (TUs), such as enhancers and promoters, as anchors. Here we use combinatoric arguments to enumerate the emergent chromatin loop networks, both in the case where TUs are labeled and where they are unlabeled. We then combine these mathematical results with those of computer simulations aimed at finding the inter-TU energy required to form a target loop network. We show that different topologies are vastly different in terms of both their combinatorial weight and energy of formation. We explain the latter result qualitatively by computing the topological weight of a given network-i.e., its partition function in statistical mechanics language-in the approximation where excluded volume interactions are neglected. Our results show that networks featuring local loops are statistically more likely with respect to networks including more nonlocal contacts. We suggest our classification of loop networks, together with our estimate of the combinatorial and topological weight of each network, will be relevant to catalog three-dimensional structures of chromatin fibers around eukaryotic genes, and to estimate their relative frequency in both simulations and experiments.

Non-Gaussian displacement distributions are universal predictors of dynamic heterogeneity in slowly varying environments. Here, we explore heterogeneous dynamics in supercooled liquid using molecular dynamics simulations and show the efficiency of the relative-entropy based measure, negentropy, in quantifying dynamic heterogeneity over the widely used non-Gaussian parameter. Our analysis shows that the heterogeneity quantified by the negentropy is significantly different from the one obtained using the conventional moment-based definition that considers deviation from Gaussianity up to lower-order moments. We extract the timescales of dynamic heterogeneity using the two methods and show that the differential changes diverge as the system experiences strong intermittency near the glass transition. Further, we interpret the entropic timescales and discuss the general implications of our work.

We derive a scheme by which to solve the Liouville equation perturbatively in the nonlinearity, which we apply to weakly nonlinear classical field theories. Our solution is a variant of the Prigogine diagrammatic method and is based on an analogy between the Liouville equation in infinite volume and scattering in quantum mechanics, described by the Lippmann-Schwinger equation. The motivation for our work is wave turbulence: A broad class of nonlinear classical field theories are believed to have a stationary turbulent state-a far-from-equilibrium state, even at weak coupling. Our method provides an efficient way to derive properties of the weak wave turbulent state. A central object in these studies, which is a reduction of the Liouville equation, is the kinetic equation, which governs the occupation numbers of the modes. All properties of wave turbulence to date are based on the kinetic equation found at leading order in the weak nonlinearity. We explicitly obtain the kinetic equation to next-to-leading order.

Anisotropic particles are often encountered in different fields of soft matter and complex fluids. In this work, we present an implementation of the coupled hydrodynamics of solid ellipsoidal particles and the surrounding fluid using the lattice Boltzmann method. A standard link-based mechanism is used to implement the solid-fluid boundary conditions. We develop an implicit method to update the position and orientation of the ellipsoid. This exploits the relations between the quaternion which describes the ellipsoid's orientation and the ellipsoid's angular velocity to obtain a stable and robust dynamic update. The proposed algorithm is validated by looking at four scenarios: (i) the steady translational velocity of a spheroid subject to an external force in different orientations, (ii) the drift of an inclined spheroid subject to an imposed force, (iii) three-dimensional rotational motions in a simple shear flow (Jeffrey's orbits), and (iv) developed fluid flows and self-propulsion exhibited by a spheroidal microswimmer. In all cases the comparison of numerical results shows good agreement with known analytical solutions, irrespective of the choice of the fluid properties, geometrical parameters, and lattice Boltzmann model, thus demonstrating the robustness of the proposed algorithm.

The three-dimensional classical Heisenberg model on a simple cubic lattice with Dzyaloshinskii-Moriya (DM) interactions between nearest-neighbors in all directions has been studied using Monte Carlo simulations. The Metropolis algorithm, combined with single histogram reweighting techniques and finite-size scaling analyses, has been used to obtain the thermodynamic behavior of the system in the thermodynamic limit. Simulations were performed with the same set of interaction parameters for both shifted boundary conditions (SBC) and fluctuating boundary conditions (FBC). Because of an incommensurability caused by the DM interaction, the SBC incorporated a fixed shift angle at the boundary which varies as a function of the DM interaction and lattice size. This SBC method decreases the simulation time significantly, but the distribution of states is somewhat different than that obtained with FBC. The ground state for nonzero DM interaction is a spiral configuration where the spins are restricted to lie in planes perpendicular to the DM vector. We found that this spiral configuration undergoes a conventional second-order phase transition into a disordered, paramagnetic state with the transition temperature being a function of the magnitude of the DM interaction. The limiting case with only DM interaction in the model has also been considered. The critical exponent ν, the critical exponent ratios α/ν, β/ν, γ/ν, as well as the critical temperature T&#95;{c} and fourth-order cumulant of the order parameter U&#95;{4}^{*} at T&#95;{c} have been estimated for different magnitudes of DM interaction. The critical exponents and cumulants at the transition are different from those for the three-dimensional Heisenberg model, but the ratios α/ν, β/ν, γ/ν, U&#95;{4}^{*}/ν are the same, implying that weak universality is valid for all values of DM interaction. Structure factor calculations for particular cases have been performed considering SBC and FBC in the simulations with different lattice sizes at the critical temperatures.

Background: Cardiovascular (CV) disease is the leading cause of death in women, but few of them are aware of the CV risks (CVRs). Most women are not aware of all the CV risk factorsand their knowledge often still does not improve their lifestyle. Methods: The Carin Women is a survey conducted among Italian women by filling out a questionnaire in the waiting rooms of clinics. The aim was to determine the level of awareness of women's cardiovascular risk, knowledge of risk factors, and lifestyle. A total of 5590 questionnaires were completed in two different periods. Results: Median age was 56 (IQR 46-65); BMI was 25 (IQR 22-29). Schooling, marital status, and rate of risk conditions were assessed; 311 women (5.57%) had already suffered a cardiovascular event. The relationship between the CV events and the number of traditional risk factors was significant. A similar curve, but without significant differences, was reported for non-traditional risk factors. From the total number of women, 23% with a high CVR and 62% with a very high CVR underestimated thei risk regardless of their level of education. Up to 43% of women underestimated female CV risk compared to male risk. Women showed a good knowledge of traditional risk factors, but only a few of them had a healthy lifestyle: 21.86% were smokers, only 45.88% performed sufficient physical activity, 27.55% did not recognize they were overweight, and only 30.4% consumed more than two daily portions of fruit and vegetables. Most women (86%) need more information about CVR. Conclusions: Italian women underestimate female CVRs and their own CVR.

Actually, there was active development of children palliative care service is expressed in increasing of the number of both corresponding departments in medical organizations and children seeking palliative care. The survey of parents of children with palliative status permitted to identify desired organizational forms of medical care of this contingent, their content and aspects of social care. Such problems as shortcomings in infrastructural and material support of departments, personnel deficiency, low level of inclusion of non-medical specialists in multidisciplinary team, need for additional training of physicians and nurses in specifics of palliative medical care and need for sufficient number of pediatric palliative care centers are identified.

Driven classical self-sustained oscillators have been studied extensively in the context of synchronization. Using the master equation, this work considers the classically driven generalized quantum Rayleigh-van der Pol oscillator, which is characterized by linear dissipative gain and loss terms as well as three nonlinear dissipative terms. Since two of the nonlinear terms break the rotational phase space symmetry, the Wigner distribution of the quantum mechanical limit cycle state of the undriven system is, in general, not rotationally symmetric. The impact of the symmetry-breaking dissipators on the long-time dynamics of the driven system are analyzed as functions of the drive strength and detuning, covering the deep quantum to near-classical regimes. Phase localization and frequency entrainment, which are required for synchronization, are discussed in detail. We identify a large parameter space where the oscillators exhibit appreciable phase localization but only weak or no entrainment, indicating the absence of synchronization. Several observables are found to exhibit the analog of the celebrated classical Arnold tongue; in some cases, the Arnold tongue is found to be asymmetric with respect to vanishing detuning between the external drive and the natural oscillator frequency.

The article presents information reflecting current consideration of strategy of food production from position of of economic sustainability, ensuring population health through compliance of principles of food safety, accessibility and quality improvement. The organic food industry with systems of production, processing, distribution and retailing develops since the 1940s and has huge impact on strategies of food consumption by population, especially in high-income countries. The priorities, goals and objectives of development of organic production in the Russian Federation are targeted to ensure favorable state of environment and preservation of human health.

The scientific biography of Vasily Dmitrievich Shervinsky, the classic of Russian therapy is described in a number of articles and monographs. However, uncovered materials and results of our studies require to specify certain aspects of his biography and his scientific school.

The study was carried out using survey technique applied to sampling of workers of the first three polyclinics of Moscow. The method was based on international questionnaire Maslach Burnout Inventory (MBI) that permitted to consider characteristics of activity of medical professionals. The analysis of results of study demonstrated that overall prevalence of burnout among doctors is 17%,among nursing personnel - 21%, among non-medical personnel - 19%. The average age of workers with professional burnout is 34-49 years. Among workers with burnout more than half of them had higher education and 30% had specialized secondary education. The workers consider as main factors of professional burnout necessity to spend most of working time at the computer (up to 92%), unrealistic expectations of patients from received medical care (up to 88%), deficiency of time for reception of patients and personal life. The majority of employees had an average (35%) and low (43%) level of reduction in personal achievements that testifies well-being of work environment. The conclusion is made that in polyclinic section of Moscow health care there are no serious conflicts in collectives and existing conflicts are within limits of working relationships.

The article considers stages of becoming of Soviet nephrology as independent scientific educational clinical discipline. The role of M. I. Vikhert in becoming of nephrology as independent clinical direction within the framework of the clinic of internal diseases is demonstrated. Also the role of E. M. Tareev as the founder of nephrology in the USSR as institutionalized clinical discipline is revealed.

The review presents analysis of scientific publications considering medical errors in intravital pathologicoanatomic diagnostic. The examples of classification, rate of diagnostic errors and possible ways of decreasing the number of diagnostic errors in pathological anatomy are considered.

Recent empirical studies offer conflicting findings regarding the relation between host fitness and the composition of its microbiome, a conflict which we term 'the microbial β- diversity conundrum'. The microbiome is crucial for host wellbeing and survival. Surprisingly, different healthy individuals' microbiome compositions, even in the same population, often differ dramatically, contrary to the notion that a vital trait should be highly conserved. Moreover, gnotobiotic individuals exhibit highly deleterious phenotypes, supporting the view that the microbiome is paramount to host fitness. However, the introduction of almost arbitrarily selected microbiota into the system often achieves a significant rescue effect of the deleterious phenotypes. This is true even for microbiota from soil or phylogenetically distant host species, highlighting an apparent paradox. We suggest several solutions to the paradox using a computational framework, simulating the population dynamics of hosts and their microbiomes over multiple generations. The answers invoke factors such as host population size, the specific mode of microbial contribution to host fitness, and typical microbiome richness, offering solutions to the conundrum by highlighting scenarios where even when a host's fitness is determined in full by its microbiome composition, this composition has little effect on the natural selection dynamics of the population., (© 2023. The Author(s).)

Social organization is commonly dynamic, with extreme examples in annual social insects, but little is known about the underlying signals and mechanisms. Bumble bee larvae with close contact to a queen do not differentiate into gynes, pupate at an earlier age, and are commonly smaller than siblings that do not contact a queen. We combined detailed observations, proteomics, microRNA transcriptomics, and gland removal surgery to study the regulation of brood development and division of labor in the annual social bumble bee Bombus terrestris . We found that regurgitates fed to larvae by queens and workers differ in their protein and microRNA composition. The proteome of the regurgitate overlaps significantly with that of the mandibular (MG) and hypopharyngeal glands (HPG), suggesting that these exocrine glands are sources of regurgitate proteins. The proteome of the MG and HPG, but not the salivary glands, differs between queens and workers, with caste-specificity preserved for the MG and regurgitate proteomes. Queens subjected to surgical removal of the MG showed normal behavior, brood care, and weight gain, but failed to shorten larval development. These findings suggest that substances in the queen MG are fed to larvae and influence their developmental program. We suggest that when workers emerge and contribute to larval feeding, they dilute the effects of the queen substances, until she can no longer manipulate the development of all larvae. Longer developmental duration may allow female larvae to differentiate into gynes rather than to workers, mediating the colony transition from the ergonomic to the reproductive phase.

The children hypertension is a serious threat to population health because uncontrolled children hypertension can result in exponential increasing of cardiovascular and cerebrovascular diseases, progression of kidney failure and premature death in adulthood. The main risk factors for primary children and adolescent hypertension are considered as cardiovascular biomarkers (fibro-blast growth), obesity, especially central obesity, overweight, low birth weight, high sodium intake, sedentary lifestyle, lack of physical activity, socioeconomic and ethnic factors, as well as family anamnesis. The special place in studying children hypertension is occupied by problem of neonatal hypertension. The most common causes of neonatal hypertension are umbilical catheter-related thrombosis, renal parenchymal disease and chronic lung disease (bronchopulmonary dysplasia), as well as low birth weight, post-menstrual age and some other maternal factors, as well as medications (inotropic medicines, caffeine) and regulation of fluid intake.

The article presents results of diagnostics of value consistence and interpersonal value conjugation in employees of medical organization. Purpose of the study is to identify the value consistence index and interpersonal value conjugation of employees of different departments of medical organization and on this basis to develop recommendations for executives concerning performance of their managerial functions. The study covered 284 employees of "The Municipal Clinical Hospital № 40 of the Moscow Health Care Department". The "Sh. Schwartz Value orientations" questionnaire was applied. The mean and centered values were calculated for each value index at both levels of values representation. At the level of normative ideals dominant value the first place in all departments except obstetrics, gynecology, and neonatology takes universalism. The employees of maternity hospital positioned safety on the first place. The second place was given to hedonism in departments of oncology, surgery and internal medicine; to kindness in departments of obstetrics, gynecology and neonatology, to achievement in department of intensive care; stimulation in department of diagnostic; safety in non-medical departments. The third place was given to safety in department of oncology, surgery and therapy; to conformity in departments of obstetrics, gynecology and neonatology; and to hedonism in non-medical departments. The comparison of value profiles of behavioral priorities established that in all departments one of the three dominant ranked values was power, in four departments - hedonism, in five departments - stimulation, in four - achievement, in one - tradition. The qualitative assessment of personality value profiles identified four types of department employees: mobile, sensitive, rational and stable one. Based on quantitative data of the Department Value Profile chart executive can develop management strategies using socio-psychological methods of personnel management.

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or collisions. Recent work demonstrates that RSR also plays a role in innate immunity by activating the human NLRP1 inflammasome. Here, we report that ZAKα and NLRP1 sense bacterial exotoxins that target ribosome elongation factors. One such toxin, diphtheria toxin (DT), the causative agent for human diphtheria, triggers RSR-dependent inflammasome activation in primary human keratinocytes. This process requires iron-mediated DT production in the bacteria, as well as diphthamide synthesis and ZAKα/p38-driven NLRP1 phosphorylation in host cells. NLRP1 deletion abrogates IL-1β and IL-18 secretion by DT-intoxicated keratinocytes, while ZAKα deletion or inhibition additionally limits both pyroptotic and inflammasome-independent non-pyroptotic cell death. Consequently, pharmacologic inhibition of ZAKα is more effective than caspase-1 inhibition at protecting the epidermal barrier in a 3D skin model of cutaneous diphtheria. In summary, these findings implicate ZAKα-driven RSR and the NLRP1 inflammasome in antibacterial immunity and might explain certain aspects of diphtheria pathogenesis., (© 2023 Robinson et al.)

Individual entities across levels of biological organization interact to reach collective decisions. In centralized neuronal networks, competing neural populations commonly accumulate information over time while increasing their own activity, and cross-inhibiting other populations until one group passes a given threshold. In social insects, there is good evidence for decisions mediated by positive feedbacks, but we found evidence for similar inhibitory signals only in honey bee (Apis mellifera) stop signals, and Pharaoh's ant- (Monomorium pharaonic) repellent pheromones, with only the former occasionally being used as cross-inhibition. We discuss whether these differences stem from insufficient research effort or represent genuine differences across levels of biological organization., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

The exploration of molecular genetic mechanisms that underlie carcinogenesis, hereditary factors of various oncological diseases, including basal cell carcinoma, the most common type of skin cancer is especially actual and significant for target strategies of public health. The diagnosis of basal cell carcinoma is based on complex clinical, radiologic and genetic examination data. The further research in the field of somatic or hereditary mutations in genes associated with basal cell carcinoma, including Patched 1 (PTCH1), Patched 2 (PTCH2), Smoothed (SMO) continue to be topical. The strategies of primary prevention of basal cell carcinoma, discussions of complex issues of decision-making concerning treatment at primary health care level, training courses and development of guidelines for general practitioners and interdisciplinary recommendations for effective early diagnosis and comprehensive care of basal cell carcinoma are to be suggested.

In Russia, one of signs of organizational formation of national stomatology as independent scientific and clinical medical discipline in the end of the XIX - early XX century, became emergence of profile societies. The most important role in this process played Gilyar Ivanovich Vilga, one of founders of the Moscow Odontology Society in 1899 and its chairman since 1900. He was one of initiators of organization of the Russian Dentistry Union and and unchallenged chairman since 1906. The article describes his public activity targeted to consolidation of all specialists in dentistry in Russia, to improvement of positioning of dental corporation, to perfection and prosperity of national dentiatry.

The purpose of the study is to identify relationship between value orientations and safety culture of workers of medical organization. The sampling consisted of 284 workers (66 men, 218 women) of medical clinic. To identify system of personal values the "Value Orientations" questionnaire by Sch. Schwartz was applied. The mean values and ranks were calculated for each value indicator. To assess safety culture the "Safety Attitudes Questionnaire" by K. N. Tsaranov et al. was applied. The data statistical processing of the data was carried out using variance analysis and correlation analysis (Pearson coefficient). The largest differences in the indicators in the group with a low level of value-intentional coherence indicator were observed in relation to values "conformity" (rank difference 2.16), "stimulation" (1.73), "universalism" (0.9), "achievement" (0.83), "independence" (0.77), "traditions" (0.61) For other values difference was less than 0.5. The largest differences in indicators in the group with high level of value-intentional coherence indicator (IVC) were observed for values "universalism" (1.01), "stimulation" (0.64), "achievement" (0.5). For the remaining values difference was less than 0.5. Assessment of safety culture revealed that below threshold of agreement (75%) were results on the scale "Recognition (understanding) of stress" in all groups of respondents. On indicator "Working conditions" below level of agreement were results of groups with low and high levels of value-intentional consistency indicator. Below threshold of agreement (75%) were results of responses to the question about the relationship with clinical pharmacologists in all groups of respondents. The value-intentional coherence index can be applied only concerning each single worker. The qualitative analysis of IVC indicator should both include its comparison at the level of normative ideals and behavioral priorities of values and to consider the spread between ranks. The values "stimulation" and "achievement" have no effect on manifestation of attitude to safety culture of medical organization. The key personal values associated with manifestations of safety culture are "power", "autonomy" and "conformality".

The maintenance of health of residents of the Northern Regions of Russia, including those living in the Arctic zone of the cbountry, is a condition of its advance development in XXI century. The percentage of Russian citizen vaccinated against the new coronavirus infection (COVID-19) does not exceed 50% after beginning of implementation of vaccination program. It can be conditioned by lower level of both of credence of citizen to health care system and health literacy.Purpose of the study is to establish determinants of vaccination of population against COVID-19 in circumpolar region of Russia as exemplified by the Arkhangelsk Oblast.The sociological survey was carried out using the interview technique of patients of medical organizations (n=433) and conditionally healthy residents of the Arkhangelsk Oblast (n=139). To evaluate the level of general health literacy the Russian version of questionnaire HLS19 - Q22-RU was applied. The most of conditionally healthy respondents and consumers of medical services looked for information about methods of prevention and treatment (80.4% and 58.2% correspondingly), had an experience of vaccination against COVID-19 (79% and 56.3% correspondingly). The relative chances of conditionally healthy respondents, women, and respondents having no children and no credence to national health care system to independently look for information related to COVID-19 is higher at 2.94, 2.08, 1.55 and 1.48-1.57 times correspondingly. The relative chances of conditionally healthy respondents having no children in family and assessing one's economic status as "higher than average" to be vaccinated against COVID-19 is higher at 4.02, 1.52, 1.53 times correspondingly. Availability of experience of vaccination against COVID-19 is conditioned by higher level of general health literacy.In the Arkhangelsk Oblast and other circumpolar regions of Russia the programs of increasing loyalty of citizen to measures of population prevention, including vaccine prevention, is to be implemented with consideration of established determinants of of vaccinations against COVID-19.

John Hunter is rightly ranks with such most famous researchers and physicians as Galen, William Harvey and Andreas Vesalius. His role as the founder of the "experimental surgery" of the New Age and the creator of the famous Hunterian Medical Museum in London is significant for the history of medicine. His contribution into development of dentistry is incontestable. His work "The Natural history of human teeth: an explanation of their structure, use, formation, growth and diseases" (1771) was translated into many languages, but it was never published in Russian. The accuracy of description of the anatomy of teeth, jaws and mouth cavity, the view? contemporary for us, of development of the jaws and their relationship with the masseters, the introduction of such terms as "canines", "incisors" and "anterior molars" into scientific circulation and everyday practice of dentists, the illustrations excellent by their quality and accuracy - all this is John Hunter. His works predetermined path of development of many medical directions, giving food for thought to his followers and disciples. The article reveals the facts of his biography, demonstrates significance of contribution of John Hunter into medicine in his works on anatomy, surgery, natural history of dentistry and stomatology.

The purpose of the study is to establish main trends in morbidity of adolescents (15-17 years old) in the regions of the Northern-Caucasus Federal Okrug in 2011-2020. The study is based on data of statistical reports on primary and general morbidity of population aged 15-17 years for 2011-2020. The results. The epidemiological situation concerning morbidity of adolescents in the Russian Federation and the Northern-Caucasus Federal Okrug is characterized by positive trend over the analyzed period. The deterioration of epidemiological situation is observed in the Karachay-Cherkessia Republic (KChR) where absolute increase in overall morbidity of adolescents comprised 105.3% and primary morbidity 49.0% and in the Stavropol Territory (ST) - 23.0% and 27.5% correspondingly. The decrease of morbidity of adolescents is observed in the Republic of Ingushetia (RI) (by 56.9% and 51.7%) and in the Chechen Republic (ChR) (by 34.6% and 45.0%). In the Republic of Dagestan (RD), an increase of overall morbidity (by 114.0%) is accompanied by decreasing of primary morbidity (by 13.2%) and in the Republic of North Ossetia-Alania (RNOA) (absolute increase in overall morbidity by 7.8% and decrease of primary morbidity by 7.0%). In the Kabardino-Balkaria Republic (KBR), there is absolute decreasing of overall morbidity (by 1.7%) with simultaneous increase of primary morbidity of adolescents (by 24.2%). However, there are features inherent in most of analyzed regions of the Northern-Caucasus Federal Okrug. The increase of overall morbidity of eye diseases in adolescents is registered in six out of seven regions with exception of the RI, the increase of primary morbidity occurred in four of them (KChR, RD, KBR, ST). The increase of general and primary morbidity of ear diseases is registered in five regions (KChR, RD, RI, KBR, RNOA). The increasing of morbidity of neoplasms registered as common for five regions (the KChR, RD, RI, KBR, the ST) and as primary one in four of them (with the exception of the ST). The conclusions. In the regions of the Northern-Caucasus Federal Okrug multi-directional dynamics of indicators of general and primary morbidity among adolescents was established with predominance of particular classes of diseases. This result testifies absence of unified policy in the field of public health targeted to maintaining healthy life-style in adolescents.

In 1918, the Dentistry subsection of the People's Commissariat of Health Care was organized with purpose of establishing national public free qualified state dental care. The organized institution was headed by P. G. Dauge, the dentist by education and the associate of Lenin by revolutionary activity. He developed dentistry reform plan as far back as the Revolution. The plan provided for organizing state dental clinics on the basis of requisitioned private dental offices and their former owners left without implements were to be engaged into public service. This process was regulated by the resolutions developed by the Dentistry subsection and adopted by the People's Commissariat of Health ("On the state organization of dental care in the Republic", "On labor service of medical personnel" ) as well as by numerous instructions and circulars. The main problems when organizing state dentistry became missing or inadequate financing, deficiency of equipment, required instruments, materials and medications as well as reluctance of dentists to be deprived of their offices and to change to state service. The organization of national state dental care was impeded by military mobilization of dentists and dental technicians that resulted in more than one third of specialists found themselves in the Red Army. The state outpatient clinics network, organized in conditions of war communism, decreased drastically after transition to the new economic policy in 1921.