434 results on '"Thayer, Sarah P"'
Search Results
2. Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
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Bausch, Dirk, Fritz, Stefan, Bolm, Louisa, Wellner, Ulrich F., Fernandez-del-Castillo, Carlos, Warshaw, Andrew L., Thayer, Sarah P., and Liss, Andrew S.
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- 2020
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3. Early detection of sporadic pancreatic cancer: summative review.
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Chari, Suresh T, Kelly, Kimberly, Hollingsworth, Michael A, Thayer, Sarah P, Ahlquist, David A, Andersen, Dana K, Batra, Surinder K, Brentnall, Teresa A, Canto, Marcia, Cleeter, Deborah F, Firpo, Matthew A, Gambhir, Sanjiv Sam, Go, Vay Liang W, Hines, O Joe, Kenner, Barbara J, Klimstra, David S, Lerch, Markus M, Levy, Michael J, Maitra, Anirban, Mulvihill, Sean J, Petersen, Gloria M, Rhim, Andrew D, Simeone, Diane M, Srivastava, Sudhir, Tanaka, Masao, Vinik, Aaron I, and Wong, David
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Humans ,Carcinoma ,Pancreatic Ductal ,Pancreatic Neoplasms ,Diagnostic Imaging ,Biopsy ,Prognosis ,Molecular Diagnostic Techniques ,Survival Analysis ,Predictive Value of Tests ,Interdisciplinary Communication ,Cooperative Behavior ,Biomedical Research ,International Cooperation ,Diffusion of Innovation ,Congresses as Topic ,Early Detection of Cancer ,Biomarkers ,Tumor ,biomarker ,diabetes ,screening ,familial ,imaging ,pancreatic ductal adenocarcinoma ,Rare Diseases ,Pancreatic Cancer ,Cancer ,Prevention ,Digestive Diseases ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.
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- 2015
4. Abstract C055: Activation of oncogenes within Tff2 expressing cells of the pancreatic ductal glands results in increased lineage stemness preceding tumorigenesis: Insights from an inducible mouse model and derived organoids
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McAndrews, Kyle L., primary, Mondal, Pinaki, additional, Maroni, Dulce, additional, Wang, Dongdong, additional, Hollingsworth, Michael A., additional, and Thayer, Sarah P., additional
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- 2024
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5. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.
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Tempero, Margaret A, Arnoletti, J Pablo, Behrman, Stephen W, Ben-Josef, Edgar, Benson, Al B, Casper, Ephraim S, Cohen, Steven J, Czito, Brian, Ellenhorn, Joshua DI, Hawkins, William G, Herman, Joseph, Hoffman, John P, Ko, Andrew, Komanduri, Srinadh, Koong, Albert, Ma, Wen Wee, Malafa, Mokenge P, Merchant, Nipun B, Mulvihill, Sean J, Muscarella, Peter, Nakakura, Eric K, Obando, Jorge, Pitman, Martha B, Sasson, Aaron R, Tally, Anitra, Thayer, Sarah P, Whiting, Samuel, Wolff, Robert A, Wolpin, Brian M, Freedman-Cass, Deborah A, and Shead, Dorothy A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Pancreatic Cancer ,Clinical Research ,Rare Diseases ,Digestive Diseases ,Adenocarcinoma ,Antineoplastic Combined Chemotherapy Protocols ,Diagnostic Imaging ,Humans ,Neoplasm Staging ,Pancreatic Neoplasms ,National Comprehensive Cancer Networks ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Health services and systems - Abstract
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors of the exocrine pancreas. These NCCN Guidelines Insights provide a summary and explanation of major changes to the 2012 NCCN Guidelines for Pancreatic Adenocarcinoma. The panel made 3 significant updates to the guidelines: 1) more detail was added regarding multiphase CT techniques for diagnosis and staging of pancreatic cancer, and pancreas protocol MRI was added as an emerging alternative to CT; 2) the use of a fluoropyrimidine plus oxaliplatin (e.g., 5-FU/leucovorin/oxaliplatin or capecitabine/oxaliplatin) was added as an acceptable chemotherapy combination for patients with advanced or metastatic disease and good performance status as a category 2B recommendation; and 3) the panel developed new recommendations concerning surgical technique and pathologic analysis and reporting.
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- 2012
6. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
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Geller, Leore T., Barzily-Rokni, Michal, Danino, Tal, Jonas, Oliver H., Shental, Noam, Nejman, Deborah, Gavert, Nancy, Zwang, Yaara, Cooper, Zachary A., Shee, Kevin, Thaiss, Christoph A., Reuben, Alexandre, Livny, Jonathan, Avraham, Roi, Frederick, Dennie T., Ligorio, Matteo, Chatman, Kelly, Johnston, Stephen E., Mosher, Carrie M., Brandis, Alexander, Fuks, Garold, Gurbatri, Candice, Gopalakrishnan, Vancheswaran, Kim, Michael, Hurd, Mark W., Katz, Matthew, Fleming, Jason, Maitra, Anirban, Smith, David A., Skalak, Matt, Bu, Jeffrey, Michaud, Monia, Trauger, Sunia A., Barshack, Iris, Golan, Talia, Sandbank, Judith, Flaherty, Keith T., Mandinova, Anna, Garrett, Wendy S., Thayer, Sarah P., Ferrone, Cristina R., Huttenhower, Curtis, Bhatia, Sangeeta N., Gevers, Dirk, Wargo, Jennifer A., Golub, Todd R., and Straussman, Ravid
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- 2017
7. Management of Locally Advanced Pancreatic Cancer: Results of an International Survey of Current Practice
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Reames, Bradley N., Blair, Alex B., Krell, Robert W., Groot, Vincent P., Gemenetzis, Georgios, Padussis, James C., Thayer, Sarah P., Falconi, Massimo, Wolfgang, Christopher L., Weiss, Matthew J., Are, Chandrakanth, and He, Jin
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- 2019
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8. Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice
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Yamaguchi, Junpei, Mino-Kenudson, Mari, Liss, Andrew S., Chowdhury, Sanjib, Wang, Timothy C., Fernández-del Castillo, Carlos, Lillemoe, Keith D., Warshaw, Andrew L., and Thayer, Sarah P.
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- 2016
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9. Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials
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Park, Joo Kyung, Hank, Thomas, Scherber, Cally M., Lillemoe, Keith D., Fernández-del Castillo, Carlos, Warshaw, Andrew L., Toner, Mehmet, Irimia, Daniel, Thayer, Sarah P., and Liss, Andrew S.
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- 2020
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10. Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis
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Liu, Xiang, Clemens, Dahn L., Grunkemeyer, James A., Price, Jeffrey D., O’Connell, Kelly, Chapman, Nora M., Storz, Peter, Wen, Haitao, Cox, Jesse L., Reid, Whitney L., Hollingsworth, Michael A., and Thayer, Sarah
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- 2019
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11. Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance
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Zutshi, Neha, primary, Mohapatra, Bhopal C, additional, Mondal, Pinaki, additional, An, Wei, additional, Goetz, Benjamin T, additional, Wang, Shou, additional, Li, Scong, additional, Storck, Matthew D, additional, Mercer, David, additional, Black, Adrian R, additional, Thayer, Sarah P, additional, Black, Jennifer, additional, Lin, Chi, additional, Band, Vimla, additional, and Band, Hamid, additional
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- 2023
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12. Supplementary Tables 1-2, Figures 1-8 from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
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Ying, Haoqiang, primary, Elpek, Kutlu G., primary, Vinjamoori, Anant, primary, Zimmerman, Stephanie M., primary, Chu, Gerald C., primary, Yan, Haiyan, primary, Fletcher-Sananikone, Eliot, primary, Zhang, Hailei, primary, Liu, Yingchun, primary, Wang, Wei, primary, Ren, Xiaojia, primary, Zheng, Hongwu, primary, Kimmelman, Alec C., primary, Paik, Ji-hye, primary, Lim, Carol, primary, Perry, Samuel R., primary, Jiang, Shan, primary, Malinn, Brian, primary, Protopopov, Alexei, primary, Colla, Simona, primary, Xiao, Yonghong, primary, Hezel, Aram F., primary, Bardeesy, Nabeel, primary, Turley, Shannon J., primary, Wang, Y. Alan, primary, Chin, Lynda, primary, Thayer, Sarah P., primary, and DePinho, Ronald A., primary
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- 2023
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13. Data from PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
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Ying, Haoqiang, primary, Elpek, Kutlu G., primary, Vinjamoori, Anant, primary, Zimmerman, Stephanie M., primary, Chu, Gerald C., primary, Yan, Haiyan, primary, Fletcher-Sananikone, Eliot, primary, Zhang, Hailei, primary, Liu, Yingchun, primary, Wang, Wei, primary, Ren, Xiaojia, primary, Zheng, Hongwu, primary, Kimmelman, Alec C., primary, Paik, Ji-hye, primary, Lim, Carol, primary, Perry, Samuel R., primary, Jiang, Shan, primary, Malinn, Brian, primary, Protopopov, Alexei, primary, Colla, Simona, primary, Xiao, Yonghong, primary, Hezel, Aram F., primary, Bardeesy, Nabeel, primary, Turley, Shannon J., primary, Wang, Y. Alan, primary, Chin, Lynda, primary, Thayer, Sarah P., primary, and DePinho, Ronald A., primary
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- 2023
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14. Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings
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Cauley, Christy E., Pitman, Martha B., Zhou, Jiahua, Perkins, James, Kuleman, Birte, Liss, Andrew S., Fernandez-del Castillo, Carlos, Warshaw, Andrew L., Lillemoe, Keith D., and Thayer, Sarah P.
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- 2015
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15. Pancreatic duct glands (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair
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Yamaguchi, Junpei, Liss, Andrew S., Sontheimer, Alexandra, Mino-Kenudson, Mari, Castillo, Carlos Fernández-del, Warshaw, Andrew L., and Thayer, Sarah P.
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- 2015
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16. The effect of antecolic versus retrocolic reconstruction on delayed gastric emptying after classic non–pylorus-preserving pancreaticoduodenectomy
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Sahora, Klaus, Morales-Oyarvide, Vicente, Thayer, Sarah P., Ferrone, Christina R., Warshaw, Andrew L., Lillemoe, Keith D., and Fernández-del Castillo, Carlos
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- 2015
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17. The influence of anesthesia on heart rate complexity during elective and urgent surgery in 128 patients
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Naraghi, Leily, Peev, Miroslav P., Esteve, Rogette, Chang, Yuchiao, Berger, David L., Thayer, Sarah P., Rattner, David W., Lillemoe, Keith D., Kaafarani, Haytham, Yeh, Daniel D., de Moya, Marc A., Fagenholz, Peter J., Velmahos, George S., and King, David R.
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- 2015
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18. Survival in ampullary cancer: Potential role of different KRAS mutations
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Valsangkar, Nakul P., Ingkakul, Thun, Correa-Gallego, Camilo, Mino-Kenudson, Mari, Masia, Ricard, Lillemoe, Keith D., Castillo, Carlos Fernández-del, Warshaw, Andrew L., Liss, Andrew S., and Thayer, Sarah P.
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- 2015
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19. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
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Jiao, Wei, Atwal, Gurnit, Polak, Paz, Karlic, Rosa, Cuppen, Edwin, Al-Shahrour, Fatima, Bailey, Peter J, Biankin, Andrew V, Boutros, Paul C, Campbell, Peter J, Chang, David K, Cooke, Susanna L, Deshpande, Vikram, Faltas, Bishoy M, Faquin, William C, Garraway, Levi, Getz, Gad, Grimmond, Sean M, Haider, Syed, Hoadley, Katherine A, Kaiser, Vera B, Kato, Mamoru, Kübler, Kirsten, Lazar, Alexander J, Li, Constance H, Louis, David N, Margolin, Adam, Martin, Sancha, Nahal-Bose, Hardeep K, Nielsen, G Petur, Nik-Zainal, Serena, Omberg, Larsson, P’ng, Christine, Perry, Marc D, Rheinbay, Esther, Rubin, Mark A, Semple, Colin A, Sgroi, Dennis C, Shibata, Tatsuhiro, Siebert, Reiner, Smith, Jaclyn, Stein, Lincoln D, Stobbe, Miranda D, Sun, Ren X, Thai, Kevin, Wright, Derek W, Wu, Chin-Lee, Yuan, Ke, Zhang, Junjun, Danyi, Alexandra, de Ridder, Jeroen, van Herpen, Carla, Lolkema, Martijn P, Steeghs, Neeltje, Morris, Quaid D, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, Barbi, Stefano, Barbour, Andrew P, Barenboim, Jonathan, Barnholtz-Sloan, Jill, Barr, Hugh, Barrera, Elisabet, Bartlett, John, Bartolome, Javier, Bassi, Claudio, Bathe, Oliver F, Baumhoer, Daniel, Bavi, Prashant, Baylin, Stephen B, Bazant, Wojciech, Beardsmore, Duncan, Beck, Timothy A, Behjati, Sam, Behren, Andreas, Niu, Beifang, Bell, Cindy, Beltran, Sergi, Benz, Christopher, Berchuck, Andrew, Bergmann, Anke K, Bergstrom, Erik N, Berman, Benjamin P, Berney, Daniel M, Bernhart, Stephan H, Beroukhim, Rameen, Berrios, Mario, Bersani, Samantha, Bertl, Johanna, Betancourt, Miguel, Bhandari, Vinayak, Bhosle, Shriram G, Bieg, Matthias, Bigner, Darell, Binder, Hans, Birney, Ewan, Birrer, Michael, Biswas, Nidhan K, Bjerkehagen, Bodil, Bodenheimer, Tom, Boice, Lori, Bonizzato, Giada, De Bono, Johann S, Boot, Arnoud, Bootwalla, Moiz S, Borg, Ake, Borkhardt, Arndt, Boroevich, Keith A, Borozan, Ivan, Borst, Christoph, Bosenberg, Marcus, Bosio, Mattia, Boultwood, Jacqueline, Bourque, Guillaume, Bova, G Steven, Bowen, David T, Bowlby, Reanne, Bowtell, David DL, Boyault, Sandrine, Boyce, Rich, Boyd, Jeffrey, Brazma, Alvis, Brennan, Paul, Brewer, Daniel S, Brinkman, Arie B, Bristow, Robert G, Broaddus, Russell R, Brock, Jane E, Brock, Malcolm, Broeks, Annegien, Brooks, Angela N, Brooks, Denise, Brors, Benedikt, Brunak, Søren, Bruxner, Timothy JC, Bruzos, Alicia L, Buchanan, Alex, Buchhalter, Ivo, Buchholz, Christiane, Bullman, Susan, Burke, Hazel, Burkhardt, Birgit, Burns, Kathleen H, Busanovich, John, Bustamante, Carlos D, Butler, Adam P, Butte, Atul J, Byrne, Niall J, Børresen-Dale, Anne-Lise, Caesar-Johnson, Samantha J, Cafferkey, Andy, Cahill, Declan, Calabrese, Claudia, Caldas, Carlos, Calvo, Fabien, Camacho, Niedzica, Campo, Elias, Cantù, Cinzia, Cao, Shaolong, Carey, Thomas E, Carlevaro-Fita, Joana, Carlsen, Rebecca, Cataldo, Ivana, Cazzola, Mario, Cebon, Jonathan, Cerfolio, Robert, Chadwick, Dianne E, Chakravarty, Dimple, Chalmers, Don, Chan, Calvin Wing Yiu, Chan, Kin, Chan-Seng-Yue, Michelle, Chandan, Vishal S, Chanock, Stephen J, Chantrill, Lorraine A, Chateigner, Aurélien, Chatterjee, Nilanjan, Chayama, Kazuaki, Chen, Hsiao-Wei, Chen, Jieming, Chen, Ken, Chen, Yiwen, Chen, Zhaohong, Cherniack, Andrew D, Chien, Jeremy, Chiew, Yoke-Eng, Chin, Suet-Feung, Cho, Juok, Cho, Sunghoon, Choi, Jung Kyoon, Choi, Wan, Chomienne, Christine, Chong, Zechen, Choo, Su Pin, Chou, Angela, Christ, Angelika N, Christie, Elizabeth L, Chuah, Eric, Cibulskis, Carrie, Cibulskis, Kristian, Cingarlini, Sara, Clapham, Peter, Claviez, Alexander, Cleary, Sean, Cloonan, Nicole, Cmero, Marek, Collins, Colin C, Connor, Ashton A, Cooper, Colin S, Cope, Leslie, Corbo, Vincenzo, Cordes, Matthew G, Cordner, Stephen M, Cortés-Ciriano, Isidro, Covington, Kyle, Cowin, Prue A, Craft, Brian, Craft, David, Creighton, Chad J, Cun, Yupeng, Curley, Erin, Cutcutache, Ioana, Czajka, Karolina, Czerniak, Bogdan, Dagg, Rebecca A, Danilova, Ludmila, Davi, Maria Vittoria, Davidson, Natalie R, Davies, Helen, Davis, Ian J, Davis-Dusenbery, Brandi N, Dawson, Kevin J, De La Vega, Francisco M, De Paoli-Iseppi, Ricardo, Defreitas, Timothy, Dei Tos, Angelo P, Delaneau, Olivier, Demchok, John A, Demeulemeester, Jonas, Demidov, German M, Demircioğlu, Deniz, Dennis, Nening M, Denroche, Robert E, Dentro, Stefan C, Desai, Nikita, Deshwar, Amit G, Desmedt, Christine, Deu-Pons, Jordi, Dhalla, Noreen, Dhani, Neesha C, Dhingra, Priyanka, Dhir, Rajiv, DiBiase, Anthony, Diamanti, Klev, Ding, Li, Ding, Shuai, Dinh, Huy Q, Dirix, Luc, Doddapaneni, HarshaVardhan, Donmez, Nilgun, Dow, Michelle T, Drapkin, Ronny, Drechsel, Oliver, Drews, Ruben M, Serge, Serge, Dudderidge, Tim, Dueso-Barroso, Ana, Dunford, Andrew J, Dunn, Michael, Dursi, Lewis Jonathan, Duthie, Fraser R, Dutton-Regester, Ken, Eagles, Jenna, Easton, Douglas F, Edmonds, Stuart, Edwards, Paul A, Edwards, Sandra E, Eeles, Rosalind A, Ehinger, Anna, Eils, Juergen, Eils, Roland, El-Naggar, Adel, Eldridge, Matthew, Ellrott, Kyle, Erkek, Serap, Escaramis, Georgia, Espiritu, Shadrielle MG, Estivill, Xavier, Etemadmoghadam, Dariush, Eyfjord, Jorunn E, Fan, Daiming, Fan, Yu, Farcas, Claudiu, Fassan, Matteo, Fatima, Aquila, Favero, Francesco, Fayzullaev, Nodirjon, Felau, Ina, Fereday, Sian, Ferguson, Martin L, Ferretti, Vincent, Feuerbach, Lars, Field, Matthew A, Fink, J Lynn, Finocchiaro, Gaetano, Fisher, Cyril, Fittall, Matthew W, Fitzgerald, Anna, Fitzgerald, Rebecca C, Flanagan, Adrienne M, Fleshner, Neil E, Flicek, Paul, Foekens, John A, Fong, Kwun M, Fonseca, Nuno A, Foster, Christopher S, Fox, Natalie S, Fraser, Michael, Frazer, Scott, Frenkel-Morgenstern, Milana, Friedman, William, Frigola, Joan, Fronick, Catrina C, Fujimoto, Akihiro, Fujita, Masashi, Fukayama, Masashi, Fulton, Lucinda A, Fulton, Robert S, Furuta, Mayuko, Futreal, P Andrew, Füllgrabe, Anja, Gabriel, Stacey B, Gallinger, Steven, Gambacorti-Passerini, Carlo, Gao, Jianjiong, Gao, Shengjie, Garred, Øystein, Garrison, Erik, Garsed, Dale W, Gehlenborg, Nils, Gelpi, Josep LL, George, Joshy, Gerhard, Daniela S, Gerhauser, Clarissa, Gershenwald, Jeffrey E, Gerstein, Mark, Gerstung, Moritz, Ghori, Mohammed, Ghossein, Ronald, Giama, Nasra H, Gibbs, Richard A, Gibson, Bob, Gill, Anthony J, Gill, Pelvender, Giri, Dilip D, Glodzik, Dominik, Gnanapragasam, Vincent J, Goebler, Maria Elisabeth, Goldman, Mary J, Gomez, Carmen, Gonzalez, Santiago, Gonzalez-Perez, Abel, Gordenin, Dmitry A, Gossage, James, Gotoh, Kunihito, Govindan, Ramaswamy, Grabau, Dorthe, Graham, Janet S, Grant, Robert C, Green, Anthony R, Green, Eric, Greger, Liliana, Grehan, Nicola, Grimaldi, Sonia, Grossman, Robert L, Grundhoff, Adam, Gundem, Gunes, Guo, Qianyun, Gupta, Manaswi, Gupta, Shailja, Gut, Ivo G, Gut, Marta, Göke, Jonathan, Ha, Gavin, Haake, Andrea, Haan, David, Haas, Siegfried, Haase, Kerstin, Haber, James E, Habermann, Nina, Hach, Faraz, Hama, Natsuko, Hamdy, Freddie C, Hamilton, Anne, Hamilton, Mark P, Han, Leng, Hanna, George B, Hansmann, Martin, Haradhvala, Nicholas J, Harismendy, Olivier, Harliwong, Ivon, Harmanci, Arif O, Harrington, Eoghan, Hasegawa, Takanori, Haussler, David, Hawkins, Steve, Hayami, Shinya, Hayashi, Shuto, Hayes, D Neil, Hayes, Stephen J, Hayward, Nicholas K, Hazell, Steven, He, Yao, Heath, Allison P, Heath, Simon C, Hedley, David, Hegde, Apurva M, Heiman, David I, Heinold, Michael C, Heins, Zachary, Heisler, Lawrence E, Hellstrom-Lindberg, Eva, Helmy, Mohamed, Heo, Seong Gu, Hepperla, Austin J, Heredia-Genestar, José María, Herrmann, Carl, Hersey, Peter, Hess, Julian M, Hilmarsdottir, Holmfridur, Hinton, Jonathan, Hirano, Satoshi, Hiraoka, Nobuyoshi, Hobolth, Asger, Hodzic, Ermin, Hoell, Jessica I, Hoffmann, Steve, Hofmann, Oliver, Holbrook, Andrea, Holik, Aliaksei Z, Hollingsworth, Michael A, Holmes, Oliver, Holt, Robert A, Hong, Chen, Hong, Eun Pyo, Hong, Jongwhi H, Hooijer, Gerrit K, Hornshøj, Henrik, Hosoda, Fumie, Hou, Yong, Hovestadt, Volker, Howat, William, Hoyle, Alan P, Hruban, Ralph H, Hu, Jianhong, Hu, Taobo, Hua, Xing, Huang, Kuan-lin, Huang, Mei, Huang, Mi Ni, Huang, Vincent, Huang, Yi, Huber, Wolfgang, Hudson, Thomas J, Hummel, Michael, Hung, Jillian A, Huntsman, David, Hupp, Ted R, Huse, Jason, Huska, Matthew R, Hutter, Barbara, Hutter, Carolyn M, Hübschmann, Daniel, Iacobuzio-Donahue, Christine A, Imbusch, Charles David, Imielinski, Marcin, Imoto, Seiya, Isaacs, William B, Isaev, Keren, Ishikawa, Shumpei, Iskar, Murat, Islam, SM Ashiqul, Ittmann, Michael, Ivkovic, Sinisa, Izarzugaza, Jose MG, Jacquemier, Jocelyne, Jakrot, Valerie, Jamieson, Nigel B, Jang, Gun Ho, Jang, Se Jin, Jayaseelan, Joy C, Jayasinghe, Reyka, Jefferys, Stuart R, Jegalian, Karine, Jennings, Jennifer L, Jeon, Seung-Hyup, Jerman, Lara, Ji, Yuan, Johansson, Peter A, Johns, Amber L, Johns, Jeremy, Johnson, Rory, Johnson, Todd A, Jolly, Clemency, Joly, Yann, Jonasson, Jon G, Jones, Corbin D, Jones, David R, Jones, David TW, Jones, Nic, Jones, Steven JM, Jonkers, Jos, Ju, Young Seok, Juhl, Hartmut, Jung, Jongsun, Juul, Malene, Juul, Randi Istrup, Juul, Sissel, Jäger, Natalie, Kabbe, Rolf, Kahles, Andre, Kahraman, Abdullah, Kakavand, Hojabr, Kalimuthu, Sangeetha, von Kalle, Christof, Kang, Koo Jeong, Karaszi, Katalin, Karlan, Beth, Karlić, Rosa, Karsch, Dennis, Kasaian, Katayoon, Kassahn, Karin S, Katai, Hitoshi, Katoh, Hiroto, Kawakami, Yoshiiku, Kay, Jonathan D, Kazakoff, Stephen H, Kazanov, Marat D, Keays, Maria, Kebebew, Electron, Kefford, Richard F, Kellis, Manolis, Kench, James G, Kennedy, Catherine J, Kerssemakers, Jules NA, Khoo, David, Khoo, Vincent, Khuntikeo, Narong, Khurana, Ekta, Kilpinen, Helena, Kim, Hark Kyun, Kim, Hyung-Lae, Kim, Hyung-Yong, Kim, Hyunghwan, Kim, Jaegil, Kim, Jihoon, Kim, Jong K, Kim, Youngwook, King, Tari A, Klapper, Wolfram, Kleinheinz, Kortine, Klimczak, Leszek J, Knappskog, Stian, Kneba, Michael, Knoppers, Bartha M, Koh, Youngil, Komorowski, Jan, Komura, Daisuke, Komura, Mitsuhiro, Kong, Gu, Kool, Marcel, Korbel, Jan O, Korchina, Viktoriya, Korshunov, Andrey, Koscher, Michael, Koster, Roelof, Kote-Jarai, Zsofia, Koures, Antonios, Kovacevic, Milena, Kremeyer, Barbara, Kretzmer, Helene, Kreuz, Markus, Krishnamurthy, Savitri, Kube, Dieter, Kumar, 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Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2023
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20. Combined burden and functional impact tests for cancer driver discovery using DriverPower
- Author
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
- Published
- 2023
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21. Integrative pathway enrichment analysis of multivariate omics data
- Author
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Paczkowska, Marta, Barenboim, Jonathan, Sintupisut, Nardnisa, Fox, Natalie S, Zhu, Helen, Abd-Rabbo, Diala, Mee, Miles W, Boutros, Paul C, Abascal, Federico, Amin, Samirkumar B, Bader, Gary D, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A, Brunak, Søren, Campbell, Peter J, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J Lynn, Fonseca, Nuno A, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W, Gerstein, Mark, Getz, Gad, Gonzalez-Perez, Abel, Guo, Qianyun, Gut, Ivo G, Haan, David, Hamilton, Mark P, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hess, Julian M, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshøj, Henrik, Isaev, Keren, Izarzugaza, Jose MG, Johnson, Rory, Johnson, Todd A, Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Kim, Jaegil, Kim, Jong K, Kim, 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Vijver, Marc J, and Veer, L van’t
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
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- 2023
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22. Pathway and network analysis of more than 2500 whole cancer genomes
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.
- Published
- 2023
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23. Divergent mutational processes distinguish hypoxic and normoxic tumours
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
- Published
- 2023
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24. Genomic footprints of activated telomere maintenance mechanisms in cancer
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Elisabetta, Serra, Stefano, Sgroi, Dennis C, Shah, Nimish C, Shahabi, Sagedeh, Shang, Catherine A, Shang, Ping, Shapira, Ofer, Shelton, Troy, Shen, Ciyue, Shen, Hui, Shepherd, Rebecca, Shi, Ruian, Shi, Yan, Shiah, Yu-Jia, Shibata, Tatsuhiro, Shih, Juliann, Shimizu, Eigo, Shimizu, Kiyo, Shin, Seung Jun, Shiraishi, Yuichi, Shmaya, Tal, Shmulevich, Ilya, Shorser, Solomon I, Short, Charles, Shrestha, Raunak, Shringarpure, Suyash S, Shriver, Craig, Shuai, Shimin, Siebert, Reiner, Sieuwerts, Anieta M, Signoretti, Sabina, Sikora, Katarzyna O, Simbolo, Michele, Simon, Ronald, Simons, Janae V, Simpson, Jared T, Simpson, Peter T, Singer, Samuel, Sinnott-Armstrong, Nasa, Sipahimalani, Payal, Skelly, Tara J, Smid, Marcel, Smith, Jaclyn, Smith-McCune, Karen, Socci, Nicholas D, Sofia, Heidi J, Soloway, Matthew G, Song, Lei, Sood, Anil K, Sothi, Sharmila, Sotiriou, Christos, Soulette, Cameron M, Span, Paul N, Spellman, Paul T, Sperandio, Nicola, Spillane, Andrew J, Spiro, Oliver, Spring, Jonathan, 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Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer.
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- 2023
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25. Data from Plectin-1 as a Novel Biomarker for Pancreatic Cancer
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Bausch, Dirk, primary, Thomas, Stephanie, primary, Mino-Kenudson, Mari, primary, Fernández-del, Castillo Carlos, primary, Bauer, Todd W., primary, Williams, Mark, primary, Warshaw, Andrew L., primary, Thayer, Sarah P., primary, and Kelly, Kimberly A., primary
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- 2023
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26. CCR Translation for This Article from Plectin-1 as a Novel Biomarker for Pancreatic Cancer
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Bausch, Dirk, primary, Thomas, Stephanie, primary, Mino-Kenudson, Mari, primary, Fernández-del, Castillo Carlos, primary, Bauer, Todd W., primary, Williams, Mark, primary, Warshaw, Andrew L., primary, Thayer, Sarah P., primary, and Kelly, Kimberly A., primary
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- 2023
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27. Supplementary Figures 1-4 from A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
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Mao, Junhao, primary, Ligon, Keith L., primary, Rakhlin, Elena Y., primary, Thayer, Sarah P., primary, Bronson, Roderick T., primary, Rowitch, David, primary, and McMahon, Andrew P., primary
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- 2023
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28. Supplementary Tables 1-3 from A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
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Mao, Junhao, primary, Ligon, Keith L., primary, Rakhlin, Elena Y., primary, Thayer, Sarah P., primary, Bronson, Roderick T., primary, Rowitch, David, primary, and McMahon, Andrew P., primary
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- 2023
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29. Supplementary Table 4 from A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
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Mao, Junhao, primary, Ligon, Keith L., primary, Rakhlin, Elena Y., primary, Thayer, Sarah P., primary, Bronson, Roderick T., primary, Rowitch, David, primary, and McMahon, Andrew P., primary
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- 2023
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30. High Performing Whipple Patients: Factors Associated with Short Length of Stay after Open Pancreaticoduodenectomy
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Lee, Grace C., Fong, Zhi Ven, Ferrone, Cristina R., Thayer, Sarah P., Warshaw, Andrew L., Lillemoe, Keith D., and Fernández-del Castillo, Carlos
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- 2014
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31. Hereditary Pancreatic Cancer
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Alsina, Janivette, Thayer, Sarah P., Chung, Daniel C., editor, and Haber, Daniel A., editor
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- 2010
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32. Not all mixed-type intraductal papillary mucinous neoplasms behave like main-duct lesions: Implications of minimal involvement of the main pancreatic duct
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Sahora, Klaus, Castillo, Carlos Fernández-del, Dong, Fei, Marchegiani, Giovanni, Thayer, Sarah P., Ferrone, Cristina R., Sahani, Dushyant V., Brugge, William R., Warshaw, Andrew L., Lillemoe, Keith D., and Mino-Kenudson, Mari
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- 2014
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33. Molecular Signaling Pathways in Pancreatic Cancer
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Boland, Genevieve M., Thayer, Sarah P., Pollock, Raphael E., editor, Lowy, Andrew M., editor, Leach, Steven D., editor, and Philip, Philip A., editor
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- 2008
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34. Understanding Hospital Readmissions After Pancreaticoduodenectomy: Can We Prevent Them?
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Fong, Zhi Ven, Ferrone, Cristina R., Thayer, Sarah P, Wargo, Jennifer A., Sahora, Klaus, Seefeld, Kimberly J., Warshaw, Andrew L., Lillemoe, Keith D., Hutter, Mathew M., and Fernández-del Castillo, Carlos
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- 2014
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35. Accurate Prediction of Nodal Status in Preoperative Patients with Pancreatic Ductal Adenocarcinoma Using Next-Gen Nanoparticle
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McDermott, Shaunagh, Thayer, Sarah P, Fernandez-Del Castillo, Carlos, Mino-Kenudson, Mari, Weissleder, Ralph, and Harisinghani, Mukesh G
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- 2013
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36. Sonic Hedgehog in pancreatic cancer: From bench to bedside, then back to the bench
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Rosow, David E., Liss, Andrew S., Strobel, Oliver, Fritz, Stefan, Bausch, Dirk, Valsangkar, Nakul P., Alsina, Janivette, Kulemann, Birte, Park, Joo Kyung, Yamaguchi, Junpei, LaFemina, Jennifer, and Thayer, Sarah P.
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- 2012
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37. 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital
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Valsangkar, Nakul P., Morales-Oyarvide, Vicente, Thayer, Sarah P., Ferrone, Cristina R., Wargo, Jennifer A., Warshaw, Andrew L., and Fernández-del Castillo, Carlos
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- 2012
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38. Targeting the MAGE A3 antigen in pancreatic cancer
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Cogdill, Alexandria P., Frederick, Dennie T., Cooper, Zachary A., Garber, Haven R., Ferrone, Cristina R., Fiedler, Amy, Rosenberg, Laura, Thayer, Sarah P., Warshaw, Andrew L., and Wargo, Jennifer A.
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- 2012
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39. Evolution of the Whipple procedure at the Massachusetts General Hospital
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Fernández-del Castillo, Carlos, Morales-Oyarvide, Vicente, McGrath, Deborah, Wargo, Jennifer A., Ferrone, Cristina R., Thayer, Sarah P., Lillemoe, Keith D., and Warshaw, Andrew L.
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- 2012
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40. Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure
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Ferrone, Cristina R., Pieretti-Vanmarcke, Rafael, Bloom, Jordan P., Zheng, Hui, Szymonifka, Jackye, Wargo, Jennifer A., Thayer, Sarah P., Lauwers, Gregory Y., Deshpande, Vikram, Mino-Kenudson, Mari, Fernández-del Castillo, Carlos, Lillemoe, Keith D., and Warshaw, Andrew L.
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- 2012
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41. Intraductal papillary mucinous neoplasms: Does a family history of pancreatic cancer matter?
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Nehra, Deepika, Oyarvide, Vicente Morales, Mino-Kenudson, Mari, Thayer, Sarah P., Ferrone, Cristina R., Wargo, Jennifer A., Muzikansky, Alona, Finkelstein, Dianne, Warshaw, Andrew L., and Castillo, Carlos Fernández-del
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- 2012
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42. Isolation and Characterization of Centroacinar/Terminal Ductal Progenitor Cells in Adult Mouse Pancreas
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Rovira, Meritxell, Scott, Sherri-Gae, Liss, Andrew S., Jensen, Jan, Thayer, Sarah P., Leach, Steven D., and Brown, Donald D.
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- 2010
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43. Generation Matters: The Nexus of Nativity, Identity, and Fertility Among Hispanic Women in the United States
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Thayer, Sarah Anne Walchuk
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Demography ,Sociology - Abstract
What explains the curious pattern of Hispanic fertility in the United States? This dissertation explores this question, and in doing so sheds new light on processes of immigrant incorporation in the United States.I examine the fertility of Hispanic women across immigrant generations, and I also examine how the fertility of immigrants and their descendants compares with a mainstream non-Hispanic white population. Previous research on immigrant fertility has drawn predominantly on classic assimilation theory, as well as theories of selectivity and disruption to explain the fertility outcomes of immigrant women in the U.S. These theories have some empirical support, but tests of them have been fairly inconsistent or inconclusive. To date, there is no coherent theory of immigrant fertility. I argue that a theory of segmented assimilation with an intergenerational disjuncture hypothesis offers the most compelling explanation for observed Hispanic fertility patterns.In an analysis of European, Asian, and Hispanic immigrant generations, I find that fertility change across immigrant generations of European and Asian women is largely consonant with what we would expect from a classic assimilation perspective—also consonant with the upwardly mobile path within a segmented assimilation framework. Although individual level demographic and socioeconomic covariates largely explain the differences between most of the European and Asian immigrant groups and their non-Hispanic white peers, they do not explain the Hispanic fertility differential. I find that a puzzling U-shaped pattern of Hispanic fertility across immigrant generations remains even after adjusting for demographic and socioeconomic factors. Strikingly, fertility decline reverses from the second to the third generation, diverging from the reference population. In a new contribution to the body of literature on immigrant fertility outcomes, I find that the composition of parent nativity of second generation women is an important predictor of their lower fertility relative to third generation women, even if the exact mechanism of action is still unknown. I theorize a number of ways this mechanism could function and argue that this finding is further evidence that fertility change across immigrant generations in the U.S. is best explained within a segmented assimilation framework enriched by an intergenerational disjunctures hypothesis. I also find evidence that women who can do so are opting out of Hispanic identity by the third generation. Second generation women of Hispanic origin (identified as such through the nativity of their parents) who did not self-identify as Hispanic are measurably different from their peers who identified as Hispanic on almost all socioeconomic, intergenerational disjuncture factors and contextual variables. The women with discordant identities are clearly a distinct group, and the explanation for this may be tightly linked to segmented assimilation theory, where selective identity occurs at the site of conflict between structural assimilation and cultural factors. By the third generation, women who have achieved assimilation to a mainstream reference group may choose not to identify themselves as Hispanic. The unique pattern of Hispanic fertility, that is, the higher fertility rates we observe in third generation Hispanic women, may be due partially to selection out of Hispanic identity.Taken together, the findings point to an assimilation process in which Hispanic immigrants become racialized and sent back to the underclass. I show that while second generation Hispanic women are characterized by much higher educational achievement, employment, and household income relative to their first generation peers, the trend stagnates or reverses by the third generation. Hope builds up with the second generation, and even legitimates some sacrifices, as exemplified by fewer children. But these immigrants and their children learn that educational achievement in the U.S. does not translate into long term gains, at least for them. Although this work sought to explain the puzzle of Hispanic fertility across immigrant generations within a segmented assimilation framework, in the end, we may find that the more theoretically compelling site of inquiry may be found by turning the question on its head. How does the curious pattern of Hispanic fertility across immigrant generations help enrich our theories of immigrant incorporation? No demographic work to date has tested the hypothesis that a selection effect with respect to ethnic identification may be taking place with third generation Hispanic women. An analysis here of second generation women finds a selection effect—that is, women who have achieved assimilation on other measures may be opting out of Hispanic identity—and suggests that this process of selection continues into the third generation and beyond. This possibility contributes a new and important modification to the segmented assimilation thesis. The findings from this dissertation demonstrate that analyses of vital events can contribute important insights into immigrant incorporation in the U.S.
- Published
- 2017
44. β Cell Transdifferentiation Does Not Contribute to Preneoplastic/Metaplastic Ductal Lesions of the Pancreas by Genetic Lineage Tracing in vivo
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Strobel, Oliver, Dor, Yuval, Stirman, Amy, Trainor, Amanda, Castillo, Carlos Fernández-del, Warshaw, Andrew L., and Thayer, Sarah P.
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- 2007
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45. Incidental Pancreatic Cysts: Do We Really Know What We Are Watching?
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Correa-Gallego, Camilo, Ferrone, Cristina R., Thayer, Sarah P., Wargo, Jennifer A., Warshaw, Andrew L., and Fernández-del Castillo, Carlos
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- 2010
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46. Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia
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Strobel, Oliver, Rosow, David E., Rakhlin, Elena Y., Lauwers, Gregory Y., Trainor, Amanda G., Alsina, Janivette, Fernández–Del Castillo, Carlos, Warshaw, Andrew L., and Thayer, Sarah P.
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- 2010
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47. Does the Mechanism of Lymph Node Invasion Affect Survival in Patients with Pancreatic Ductal Adenocarcinoma?
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Konstantinidis, Ioannis T., Deshpande, Vikram, Zheng, Hui, Wargo, Jennifer A., Fernandez-del Castillo, Carlos, Thayer, Sarah P., Androutsopoulos, Vasiliki, Lauwers, Gregory Y., Warshaw, Andrew L., and Ferrone, Cristina R.
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- 2010
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48. Added Value of Selected Images Embedded Into Radiology Reports to Referring Clinicians
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Iyer, Veena R., Hahn, Peter F., Blaszkowsky, Lawrence S., Thayer, Sarah P., Halpern, Elkan F., and Harisinghani, Mukesh G.
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- 2010
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49. Metastatic Tumors in the Pancreas in the Modern Era
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Konstantinidis, Ioannis T., Dursun, Abdulmetin, Zheng, Hui, Wargo, Jennifer A., Thayer, Sarah P., Fernandez-del Castillo, Carlos, Warshaw, Andrew L., and Ferrone, Cristina R.
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- 2010
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50. Plectin-1 is a Biomarker of Malignant Pancreatic Intraductal Papillary Mucinous Neoplasms
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Bausch, Dirk, Mino-Kenudson, Mari, Fernández-del Castillo, Carlos, Warshaw, Andrew L., Kelly, Kimberly A., and Thayer, Sarah P.
- Published
- 2009
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