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162 results on '"Thapa, Sangharsha"'

23. Biomarker role of maternal soluble human leukocyte antigen G in pre‐eclampsia: A meta‐analysis.

Author

Bhattarai, Abhinav, Shah, Sangam, Dahal, Krishna, Neupane, Raksha, Thapa, Sangharsha, Neupane, Niraj, Barboza, Joshuan J., Shrestha, Anisha, Sah, Ranjit, and Apostolopoulos, Vasso

Subjects
HLA histocompatibility antigens, ECLAMPSIA, PREECLAMPSIA, BIOMARKERS, FETAL tissues, HISTOCOMPATIBILITY class I antigens
Abstract

Introduction: Human leukocyte antigen‐G (HLA‐G) is a non‐classical class I HLA molecule shown to regulate the immunomodulation of maternal immune cells to prevent fetal tissue destruction. Low levels of freely circulating maternal soluble HLA‐G (sHLA‐G) have been observed in pre‐eclampsia, however, no pooled evidence exists. This meta‐analysis aimed to generate pooled findings on the association of sHLA‐G levels with pre‐eclampsia and is the first study to perform a trimester‐wise comparison of the levels of sHLA‐G in preeclamptic cases and normal pregnant controls. Methods: The databases PubMed, Emba, Web of Science, and Google Scholar through May 31, 2023. Preeclamptic women were defined as cases and normal pregnancies as controls. Data on the level of sHLA‐G in cases and controls was extracted and subjected to a meta‐analysis using a random‐effects model. The pooled effect was expressed in terms of standardized mean difference (SMD). Sensitivity analysis was performed to investigate the effect of the exclusion of each study on the pooled results. Publication bias was assessed statistically. Results: Nine studies with altogether 567 PE cases and 1132 normal pregnancy controls were included in the meta‐analysis. The first and third trimester levels of sHLA‐G in PE cases were significantly lower than that of normal pregnant controls: (SMD: −0.84 [−1.29; −0.38]; p =.003; I2 = 54%) and (SMD: −0.39 [−0.71; −0.06]; p =.02; I2 = 79%) respectively. Sensitivity analysis revealed significant fluctuations in the pooled findings when few studies were excluded, raising questions on the consistency of results among studies. Conclusion: Although we found that first and third‐trimester sHLA‐G levels in pre‐eclampsia are significantly lower, taking into consideration the inconsistent results from the sensitivity analysis, our findings advocate the demand for more studies with larger sample sizes to generate solid ground pooled evidence on the predictive role of sHLA‐G in pre‐eclampsia. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Insights into the interplay between Epstein‐Barr virus (EBV) and multiple sclerosis (MS): A state‐of‐the‐art review and implications for vaccine development.

Author

Mohammadzamani, Mahtab, Kazemzadeh, Kimia, Chand, Swati, Thapa, Sangharsha, Ebrahimi, Narges, Yazdan Panah, Mohammad, Shaygannejad, Vahid, and Mirmosayyeb, Omid

Subjects
AUTOIMMUNE diseases, EPSTEIN-Barr virus, VACCINE development, MULTIPLE sclerosis, MOLECULAR mimicry, CENTRAL nervous system diseases
Abstract

Background and Aims: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). MS results from an inflammatory process leading to the loss of neural tissue and increased disability over time. The role of Epstein Barr Virus (EBV), as one of the most common global viruses, in MS development has been the subject of several studies. However, many related questions are still unanswered. This study aimed to review the connection between MS and EBV and provide a quick outline of MS prevention using EBV vaccination. Methods: For this narrative review, an extensive literature search using specific terms was conducted across online databases, including PubMed/Medline, Scopus, Web of Science, and Google Scholar, to identify pertinent studies. Results: Several studies proved that almost 100% of people with MS showed a history of EBV infection, and there was an association between high titers of EBV antibodies and an increased risk of MS development. Various hypotheses are proposed for how EBV may contribute to MS directly and indirectly: (1) Molecular Mimicry, (2) Mistaken Self, (3) Bystander Damage, and (4) Autoreactive B cells infected with EBV. Conclusion: Given the infectious nature of EBV and its ability to elude the immune system, EBV emerges as a strong candidate for being the underlying cause of MS. The development of an EBV vaccine holds promise for preventing MS; however, overcoming the challenge of creating a safe and efficacious vaccine presents a significant obstacle. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study

Author

Shah, Sangam, primary, Paudel, Kiran, additional, Bhattarai, Abhinav, additional, Thapa, Sangharsha, additional, Bhusal, Sandesh, additional, Adhikari, Yagya R., additional, Adhikari, Tara B., additional, Bhatta, Nikita, additional, Mandal, Prince, additional, Sharma, Pratima, additional, Budha, Bishal, additional, Aryal, Shova, additional, Das, Santa K., additional, and Pant, Pankaj, additional

Published
2023
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30. Anterior Cruciate Ligament Tear Using Magnetic Resonance Imaging among Patients Undergoing Arthroscopy in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Author

Shrestha, Rohit, primary, Khadka, Sushant Kumar, additional, Chaudhary, Aashutosh, additional, Acharya, Shreedhar Prasad, additional, Malla, Manasil, additional, Gautam, Prabesh, additional, Maharjan, Sagar, additional, Basi, Ashkal, additional, Thapa, Sangharsha, additional, and Karki, Subindra, additional

Published
2023
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31. Hantavirus infection with Renal Failure and Proteinuria, Colorado, USA, 2019

Author

Chand, Swati, Thapa, Sangharsha, Kon, Shelley, Johnson, Steven C., Poeschla, Eric M., Franco-Paredes, Carlos, Rodriguez-Morales, Alfonso J., Mattar, Salim, and Henao-Martinez, Andres F.

Subjects
Proteinuria, Kidney failure, Hemorrhagic fevers, Infection, Hantavirus infections, Kidney diseases, Rodents, Pneumonia, Respiratory insufficiency, Glomerulonephritis, Diseases, Health
Abstract

In the United States, 20-40 hantavirus cases are reported annually. Human infections result from inhalation of aerosolized secretions of infected rodents. Hantavirus pulmonary syndrome (HPS) is associated with pneumonitis and [...]

Published
2020
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34. BRIDGE-TO-BRIDGE THERAPY FOR ADVANCED HEART FAILURE

Author

Chand, Swati, primary, Pendela, Venkata Satish, additional, Rai, Devesh, additional, Thapa, Sangharsha, additional, Abbas, Syed Faiz, additional, Oates, Patricia, additional, Wojciechowski, Katrina J., additional, and Feitell, Scott Clinton, additional

Published
2023
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39. Impact of COVID‑19 infection in patients with neurodegenerative diseases with particular focus on Alzheimer’s and Parkinson’s disease

Author

Guntipalli, Prathima, primary, Gara, Sirisha, additional, Poudel, Sujan, additional, Hans, Aakash, additional, Usman, Muhammad Abdullah, additional, Dhar, Deeksha, additional, Pakala, Ramya, additional, Shah, Sangam, additional, Thapa, Sangharsha, additional, Acharya, Sudarshan, additional, Nedd, Kester J., additional, and Kara, Sam, additional

Published
2022
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41. Managing Chronic Neuropathic Pain: Recent Advances and New Challenges

Author

Hange, Namrata, primary, Poudel, Sujan, additional, Ozair, Saleha, additional, Paul, Trissa, additional, Nambakkam, Meghna, additional, Shrestha, Rakchhya, additional, Greye, Farrah, additional, Shah, Sangam, additional, Raj Adhikari, Yagya, additional, Thapa, Sangharsha, additional, and Patel, Pooja, additional

Published
2022
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