Search

Microplastic (MP) distribution in river sediment, influenced by water regimes and pollution sources, remains understudied in the current literature. This study examines the combined impacts of seasonal variation and waterway differences on MP concentration in the sediment of the Saigon River and its tributaries, while identifying potential sources. Paired sediment samples were collected from eleven sites along the river and its tributaries during rainy and dry seasons. MPs from these 44 samples were separated, quantified, and characterized for a comprehensive assessment. The results revealed that MP concentrations in sediments ranged from 140 to 1200 items kg -1 , with predominant characteristics of fiber particles, white color, and particle sizes ranging from 200 to 500 μm. During the rainy season, MP concentrations were similar between the river (584 items kg -1 ) and tributaries (553 items kg -1 ), while during the dry season, tributaries exhibited statistically higher MP concentrations (737 items kg -1 ) than the river (351 items kg -1 ). Notably, the river, despite being farther from the sources, had a higher proportion of smaller MPs (<200 μm), while larger particles (>200 μm) were more prevalent in tributaries. These discrepancies are attributed to the combined impacts of water flow patterns and pollution sources, derived from residential, industrial, and agricultural activities. In brief, MP pollution in the river and tributary sediments is influenced by the interplay of seasonal variation and waterway characteristics, determined by water flow patterns and pollution sources. These findings emphasize the need for specific management strategies that account for spatial and temporal variations in MP distribution., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Interprofessional education is acknowledged as an efficacious strategy for fostering collaboration among healthcare professionals, especially in developing countries where interdisciplinarity and cooperation among healthcare practitioners are notably deficient. The present study aimed to investigate the readiness among medical, pharmacy, public health, and nursing faculties for development of an IPE curriculum at a university in Vietnam. Employing a quantitative approach, the revised version of the Readiness for Interprofessional Learning Scale (RIPLS) questionnaire, comprising 19 items, was utilized to gather data from sixty-nine lecturers, including 26 medicine, 23 pharmacy, 11 public health, and 9 nursing faculties. Total scores and subscores (pertaining to teamwork and collaboration, professional identity, and roles and responsibilities) were subjected to comparison using the Kruskal-Wallis and Mann-Whitney U tests. Findings revealed a high level of readiness among all faculty members toward IPE with little difference between each faculty. However, nursing lecturers exhibited a more favorable attitude toward the roles and responsibilities associated with IPE in contrast to their counterparts in the medicine faculty (1.89 ± 1.02 vs 3.15 ± 0.63, p = 0.0048). Further study with deep interview methods should be done to explore the barriers of faculty members as well as of the leadership in developing IPE., Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare., (Copyright © 2023. Published by Elsevier Inc.)

The aims of this research is to evaluate the impact of Environmental, Social and Governance (ESG) information disclosure (using both financial and non-financial information) on stock prices of businesses in Vietnam; From there, propose recommendations to promote transparent practices and information disclosure about ESG of businesses related activities; Contribute to developing sustainable investment goals in businesses, and the financial market in general. Based on the (Ohlson, 1995) [40] valuation model, and developed by Barth and Clinch (2009) [41] the research was conducted empirically in 30 listed companies in Vietnam in the period 2019-2022. Research results based on the GLS method show that ESG positively impacts stock prices. Additionally, this paper conducted an in-depth analysis of each individual pillar and found that the environmental pillar was considered the most meaningful to market participants. However, the correlation between ESG and stock prices is weakened for environmentally sensitive businesses. This study also makes a valuable contribution to the current literature on non-financial information reporting by using manually collected data and investigating the effects of ESG reporting on market participants in the public system voluntary information disclosure system of an emerging market like Vietnam., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Combination of organoclay sorption with manganese(IV) oxide (MnO 2 ) catalyzed catechol oxidation was studied for the removal of a dicarboximide fungicide, iprodione, from water. Iprodion in water was sorbed on didodecyldimethylammonium bromide (DDAB)-modified montmorillonite (MT) organoclay and converted into the degraded product, 3,5-dichloroaniline (DCA). The degree of sorption increased by the modification with DDAB, because of the formation of a hydrophobic region for the incorporation of iprodione and negligibly interfered by coexisting MnO 2 . The half-life for the degradation of irodione in water at 25 °C was 7 days, whreas it reduced to 15 min in the organoclay. The activation energy, 65.4 ± 4.8 kJ mol -1 , for the first-order reaction in the aqueous solution (pH 7.0) decreased to 43.9 ± 1.8 kJ mol -1 in the organoclay, indicating the catalytic activity of the organoclay that accelerates the hydrolysis reaction of iprodione. In the coexistence of appropriate amounts of MnO 2 and catechol, the degraded product, DCA, reacted with oxidized products of catechol to form a water-insoluble precipitate and was successfully eliminated from water. The results obtained in the present study strongly suggest the applicability of the combined method of organoclay sorption method and MnO 2 -catalyzed oxidation for the diffusion control of toxic agrochemicals., (© 2024. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.)

Clean water is an integral part of industries, agricultural activities and human life, but water contamination by toxic dyes, heavy metals, and oil spills is increasingly serious in the world. Aerogels with unique properties such as highly porous and extremely low density, tunable surface modification, excellent reusability, and thermal stability can contribute to addressing these issues. Thanks to high purity, biocompatibility and biodegradability, bacterial cellulose can be an ideal precursor source to produce aerogels. Here, we review the modification, regeneration, and applications of bacterial cellulose-based aerogels for water treatment. The modification of bacterial cellulose-based aerogels undergoes coating of hydrophobic agents, carbonization, and incorporation with other materials, e.g., ZIF-67, graphene oxide, nanoparticles, polyaniline. We emphasized features of modified aerogels on porosity, hydrophobicity, density, surface chemistry, and regeneration. Although major limits are relevant to the use of toxic coating agents, difficulty in bacterial culture, and production cost, the bacterial cellulose aerogels can obtain high performance for water treatment, particularly, catastrophic oil spills., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Flowers are often discarded after cultural and religious events, making it worthwhile to explore the utilization of this floral waste for material production. Floral extracts contain a diverse array of phytochemicals such as polyphenols, flavonoids, and reducing sugars, which play a significant role in the formation and influencing the properties of zinc oxide (ZnO) nanoparticles. In this review, we delve into the importance of floral extract, methodology, mechanism, and influencing factors in the production of ZnO nanoparticles. Additionally, the role of green ZnO nanoparticles as an adsorbent and photocatalyst for water treatment is discussed. These floral extract-mediated ZnO nanoparticles exhibit advantages in agricultural and biomedical applications, including promoting seed germination and demonstrating antibacterial, anticancer, and antifungal properties. Cost analysis reveals that while various expenses are associated with ZnO production, scaling up processes can help reduce these costs. This review underscores the potential of floral waste extract for the synthesis of green ZnO nanoparticles, thereby contributing to waste-to-wealth strategies and adhering to green chemistry principles., Competing Interests: The authors declare that there are no conflicts of interest., (This journal is © The Royal Society of Chemistry.)

The situation of discharging a large amount of dyes from the textile industries has caused many adverse effects on human health and the ecosystems. Emerging bio-nanomaterials represent a new trend in efficient dye removal in aqueous media. Herein, we mention that MgFe 2 O 4 bioprepared using gerbera extract has been successfully used to adsorb malachite green (MG) in water. A comparison was made to determine the dye removal efficiency between biogenic MgFe 2 O 4 (MFOB) and chemical MgFe 2 O 4 (MFOC). The spherical MFOB material exhibited a large surface area of 85.0 m 2 g -1 and high crystallinity. The obtained outcomes showed that the highest adsorption capacity of MG dye was 584.49 mg g -1 at a MFOB dose of 0.05 g L -1 and MG concentration of 10 mg L -1 . Higher correlation coefficients in the Langmuir isotherm suggested monolayer adsorption of MG. The Box-Behnken design and response surface method were established to optimize MG removal percentage under the conditions, i.e., initial MG concentration (10-30 mg L -1 ), adsorbent dose (0.02-0.08 g L -1 ), and pH of dye solution (6-8). MFOB had good reusability with high removal efficiencies after three continuous cycles. Post reuse, this adsorbent still showed excellent stability through the verification of their structural properties in comparison with fresh MFOB, showing potential for practical applications., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Recently, there has been a notable rise in the prevalence of persistent pollutants in the environment, posing a significant hazard due to their toxicity and enduring nature. Conventional wastewater treatment methods employed in treatment plants rarely address these persistent pollutants adequately. Meanwhile, the concept of green synthesis has garnered considerable attention, owing to its environmentally friendly approach that utilizes fewer toxic chemicals and solvents. The utilization of materials derived from sustainable sources presents a promising avenue for solving pressing environmental concerns. Among the various sources of biological agents, plants stand out for their accessibility, eco-friendliness, and rich reserves of phytochemicals suitable for material synthesis. The plant extract-mediated synthesis of zinc oxide nanoparticles (ZnONPs) has emerged as a promising solution for applications in wastewater treatment. Thorough investigations into the factors influencing the properties of these green ZnONPs are essential to establish a detailed and reliable synthesis process. Major weaknesses inherent in ZnONPs can be addressed by changing the optical, magnetic, and interface properties through doping with various semiconductor materials. Consequently, research efforts to mitigate water pollution are being driven by both the future prospects and limitations of ZnO-based composites. This review underscores the recent advancements of plant extract-mediated ZnONP composites for water treatment., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

During a 2023 outbreak of Mycoplasma pneumoniae-associated community-acquired pneumonia among children in northern Vietnam, we analyzed M. pneumoniae isolated from nasopharyngeal samples. In almost half (6 of 13) of samples tested, we found known A2063G mutations (macrolide resistance) and a novel C2353T variant on the 23S rRNA gene.

A simple approach was developed to synthesize cobalt ferrite nanoparticles/graphene quantum dots (CF/GQDs). The material was prepared from a homogeneous mixture of iron nitrate, cobalt nitrate, and starch at 140, 180 and 200 °C in a 24 h thermal hydrolysis process. The obtained materials were characterised by using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, ultraviolet-visible diffuse reflectance spectroscopy, Fourier-transform infrared spectroscopy, photoluminescence spectroscopy, vibrating-sample magnetometry, and nitrogen adsorption/desorption isotherms. Cobalt ferrite crystals of around 8-10 nm and graphene quantum dots formed directly at 200 °C. Stacking GQDs sheets onto the CF nanoparticles resulted in CF/GQDs nanoparticles. The nanocomposite exhibits satisfactory fluorescent and superparamagnetic properties, which are vital for catalytic applications. The CF/GQDs catalyse significantly the degradation of methylene blue (MB) under visible light. The catalyst can be recycled with an external magnetic field and displays suitable stability. Also, it was reused in three successive experiments with a loss of efficiency of about 5%. The CF/GQDs are considered as an efficient photocatalyst for MB degradation and other dyes., Competing Interests: The authors have no relevant financial or non-financial interests to disclose., (Copyright © 2024, Anh et al.)

Metal-organic frameworks (MOFs), a burgeoning class of coordination polymers, have garnered significant attention due to their outstanding structure, porosity, and stability. They have been extensively studied in catalysis, energy storage, water harvesting, selective gas separation, and electrochemical applications. Recent advancements in post-synthetic strategies, surface functionality, and biocompatibility have expanded the application scope of MOFs, particularly in various biomedical fields. Herein, we review MOF-based nanomaterials bioimaging nanoplatforms in magnetic resonance imaging, computed tomography, and fluorescence imaging. MOFs serve as the foundation for biosensors, demonstrating efficiency in sensing H 2 O 2 , tumor biomarkers, microRNA, and living cancer cells. MOF-based carriers are well designed in drug delivery systems and anticancer treatment therapies. Additionally, we examine the challenges and prospects of MOFs in surface modification, release of metal ions, and interaction with intracellular components, as well as their toxicity and long-term effects., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

One of the representative coordination polymers, metal-organic frameworks (MOFs) material, is of hotspot interest in the multi field thanks to their unique structural characteristics and properties. As a novel hierarchical structural class, MOFs show diverse topologies, intrinsic behaviors, flexibility, etc. However, bare MOFs have less desirable biofunction, high humid sensitivity and instability in water, restraining their efficiencies in biomedical and environmental applications. Thus, a structural modification is required to address such drawbacks. Herein, we pinpoint new strategies in the synthesis and functionalization of MOFs to meet demanding requirements in in vitro tests, i.e., antibacterial face masks against corona virus infection and in wound healing and nanocarriers for drug delivery in anticancer. Regarding the treatment of wastewater containing emerging pollutants such as POPs, PFAS, and PPCPs, functionalized MOFs showed excellent performance with high efficiency and selectivity. Challenges in toxicity, vast database of clinical trials for biomedical tests and production cost can be still presented. MOFs-based composites can be, however, a bright candidate for reasonable replacement of traditional nanomaterials in biomedical and wastewater treatment applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

A major challenge that humans facing is the uncontrolled discharge of antibiotic-containing wastewater into the environment, accompanying with huge threats to human community. The utilization of cost-effective biomass-based adsorbents is considered a potential solution for the treatment of antibiotic wastewater. This study aims to optimize the synthesis of MgFe 2 O 4 nanoparticles loaded on prickly pear biochar (PPB) with outstanding sulfadiazine adsorbability using response surface methodology. Thirteen materials (MgFe 2 O 4 -PPB) produced based on Box-Behnken design were tested to evaluate the impact of the main factors on the material preparation process, including ratio of MgFe 2 O 4 :PPB precursors, calcination temperature and calcination time. Under optimized conditions, i.e., MgFe 2 O 4 :PPB ratio 0.5, temperature 600 °C and time 1 h, the production yield of 46.5% and sulfadiazine removal percentage of 85.4% were obtained. Characterization of optimized MgFe 2 O 4 -PPB indicated the good porosity and functionality suitable for the adsorption of sulfadiazine. Elovich model showed the best description of kinetic process. Temkin model was considered to be an accurate description of the isotherm adsorption. Proposed mechanism for antibiotic adsorption onto MgFe 2 O 4 -PPB was described. We clarify cost-benefit analysis to asses the importance of MgFe 2 O 4 -PPB as well as the economic and environmental impacts of biochar-based composites., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Methylene blue (MB) is hazardous in natural water because this dye causes serious diseases that endangers public health and ecosystems. Photocatalytic degradation is a prominent technique for achieving the effective elimination of dye pollutants from wastewater and contribute vitally to ecology and environmental safety. Herein, Cu 2+ -substituted ZnFe 2 O 4 nanomaterials (Cu x Zn 1-x Fe 2 O 4 ; x = 0, 0.1, 0.2, 0.3, 0.4, 0.6) were synthesized, characterized, and applied for the photocatalytic degradation of MB dye beneath visible light with the assistance of hydrogen peroxide (H 2 O 2 ). The feature of the photo-catalysts was determined by XRD, EDX, FTIR, DRS, BET, SEM, and TEM techniques. Incorporation of Cu 2+ ions changed the crystalline phase, particle size, morphology, and surface area. The photocatalysis condition was optimized with the following major factors, the amout of doping Cu 2+ ions, H 2 O 2 concentration, adsorbent dosage, and MB concentration. As a result, the photocatalytic MB degradation efficiency by Cu 0.6 Zn 0.4 Fe 2 O 4 catalyst was 99.83% within 90 min under LED light (λ ≥ 420 nm), which was around 4 folds higher than that of pure ZnFe 2 O 4 . The photo-Fenton kinetics were in accordance with the pseudo-first-order kinetic model (R 2  = 0.981), giving the highes rate constant of 0.034 min -1 . It can be, therefore, concluded that Cu 2+ substitution considerably boosted the photocatalytic activity of Cu x Zn 1-x Fe 2 O 4 ZnFe 2 O 4 , suggesting a bright prospect of Cu 0.6 Zn 0.4 Fe 2 O 4 as a photo-catalyst in the dyes wastewater treatment., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Effect of air bubbles on the membrane filtration of a basic dye, rhodamine B (RB), using a hydrophilic PTFE membrane filter (pore size: 0.20 μm) was studied. The air bubbles were generated by vigorously mixing the aqueous solution containing 0.05% (v/v) of 1-butanol with a shaft generator of a homogenizer. RB being far smaller than the pore size of the membrane filter could not be rejected without air bubbles, but it was rejected by the membrane filter in the presence of air bubbles. The rejection ratio increased with increasing the rotation speed of the shaft generator because of the increase in the amount of air bubbles and therefore the increase in the surface area of air bubbles for the adsorption of RB. On the other hand, another basic dye, methylene blue (MB), was negligibly rejected in the same condition. Dynamic surface tension measurement of aqueous solutions containing different amounts of dye indicated that RB strongly adsorbed to the air-water interface, while MB hardly adsorbed. The results obtained in the present study strongly suggest the potential usefulness of air bubbles for the selective microfiltration of dissolved organic molecules or ions., (© 2023. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.)

MnO 2 nanoparticles have played a vital role in biomedical, catalysis, electrochemical and energy storage fields, but requiring toxic chemicals in the fabrication intercepts their applications. There is an increasing demand for biosynthesis of MnO 2 nanoparticles using green sources such as plant species in accordance with the purposes of environmental mitigation and production cost reduction. Here, we review recent advancements on the use of natural compounds such as polyphenols, reducing sugars, quercetins, etc. Extracted directly from low-cost and available plants for biogenic synthesis of MnO 2 nanoparticles. Role of these phytochemicals and formation mechanism of bio-medicated MnO 2 nanoparticles are shed light on. MnO 2 nanoparticles own small particle size, high crystallinity, diverse morphology, high surface area and stability. Thanks to higher biocompatibility, bio-mediated synthesized MnO 2 nanoparticles exhibited better antibacterial, antifungal, and anticancer activity than chemically synthesized ones. In terms of wastewater treatment and energy storage, they also served as efficient adsorbents and catalyst. Moreover, several aspects of limitation and future outlook of bio-mediated MnO 2 nanoparticles in the fields are analyzed. It is expected that the present work not only expands systematic understandings of synthesis methods, properties and applications MnO 2 nanoparticles but also pave the way for the nanotechnology revolution in combination with green chemistry and sustainable development., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Oxygen evolution reaction (OER) under acidic conditions becomes of significant importance for the practical use of a proton exchange membrane (PEM) water electrolyzer. In particular, maximizing the mass activity of iridium (Ir) is one of the maiden issues. Herein, the authors discover that the Ir-doped calcium copper titanate (CaCu₃Ti₄O₁₂, CCTO) perovskite exhibits ultrahigh mass activity up to 1000 A g Ir -1 for the acidic OER, which is 66 times higher than that of the benchmark catalyst, IrO 2 . By substituting Ti with Ir in CCTO, metal-oxygen (M-O) covalency can be significantly increased leading to the reduced energy barrier for charge transfer. Further, highly polarizable CCTO perovskite referred to as "colossal dielectric", possesses low defect formation energy for oxygen vacancy inducing a high number of oxygen vacancies in Ir-doped CCTO (Ir-CCTO). Electron transfer occurs from the oxygen vacancies and Ti to the substituted Ir consequentially resulting in the electron-rich Ir and -deficient Ti sites. Thus, favorable adsorptions of oxygen intermediates can take place at Ti sites while the Ir ensures efficient charge supplies during OER, taking a top position of the volcano plot. Simultaneously, the introduced Ir dopants form nanoclusters at the surface of Ir-CCTO, which can boost catalytic activity for the acidic OER., (© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)

Magnetic nanoparticles, particularly ZnFe 2 O 4 are of enormous significance in biomedical and water treatment fields. However, chemical synthesis of ZnFe 2 O 4 nanoparticles endures some major limitations, e.g., the use of toxic substances, unsafe procedure, and cost-ineffectiveness. Biological methods are more preferable approaches since they take advantages of biomolecules available in plant extract serving as reducing, capping, and stabilizing agents. Herein, we review plant-mediated synthesis and properties of ZnFe 2 O 4 nanoparticles for multiple applications in catalytic and adsorption performance, biomedical, catalyst, and others. Effect of several factors such as Zn 2+ /Fe 3+ /extract ratio, and calcination temperature on morphology, surface chemistry, particle size, magnetism and bandgap energy of obtained ZnFe 2 O 4 nanoparticles was discussed. The photocatalytic activity and adsorption for removal of toxic dyes, antibiotics, and pesticides were also evaluated. Main results of antibacterial, antifungal and anticancer activities for biomedical applications were summarized and compared. Several limitations and prospects of green ZnFe 2 O 4 as an alternative to traditional luminescent powders have been proposed., Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The occurrence of textile dyeing wastewater discharged into the environment has been recently increasing, resulting in harmful effects on living organisms and human health. The use of green nanoparticles for water decontamination has received much attention. Floral waste can be extracted with the release of natural compounds, which act as reducing and stabilizing agents during the biosynthesis of nanoparticles. Herein, we report the utilization of Chrysanthemum spp. floral waste extract to synthesize green ZnFe 2 O 4 @ZnO (ZFOZx) nanocomposites for the photocatalytic degradation of Congo red under solar light irradiation. The various molar ratio of ZnFe 2 O 4 (0-50%) was incorporated into ZnO nanoparticles. The surface area of green ZFOZx nanocomposites was found to increase (7.41-42.66 m 2  g -1 ) while their band gap energy decreased from 1.98 eV to 1.92 eV. Moreover, the results exhibited the highest Congo red dye degradation efficiency of 94.85% at a concentration of 5.0 mg L -1 , and a catalyst dosage of 0.33 g L -1 . The • O 2 - reactive species played a vital role in the photocatalytic degradation of Congo red dye. Green ZFOZ3 nanocomposites had good recyclability with at least three cycles, and an excellent stability. The germination results showed that wastewater treated by ZFOZ3 was safe enough for bean seed germination. We expect that this work contributes significantly to developing novel green bio-based nanomaterials for environmental remediation as well as reducing the harm caused by flower wastes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Nowadays, advancements in nanotechnology have efficiently solved many global problems, such as environmental pollution, climate change, and infectious diseases. Nano-scaled materials have played a central role in this evolution. Chemical synthesis of nanomaterials, however, required hazardous chemicals, unsafe, eco-unfriendly, and cost-ineffective, calling for green synthesis methods. Here, we review the green synthesis of MgO nanoparticles and their applications in biochemical, environmental remediation, catalysis, and energy production. Green MgO nanoparticles can be safely produced using biomolecules extracted from plants, fungus, bacteria, algae, and lichens. They exhibited fascinating and unique properties in morphology, surface area, particle size, and stabilization. Green MgO nanoparticles served as excellent antimicrobial agents, adsorbents, colorimetric sensors, and had enormous potential in biomedical therapies against cancers, oxidants, diseases, and the sensing detection of dopamine. In addition, green MgO nanoparticles are of great interests in plant pathogens, phytoremediation, plant cell and organ culture, and seed germination in the agricultural sector. This review also highlighted recent advances in using green MgO nanoparticles as nanocatalysts, nano-fertilizers, and nano-pesticides. Thanks to many emerging applications, green MgO nanoparticles can become a promising platform for future studies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

The global occurrence of textile dyes pollution has recently emerged, posing a serious threat to ecological systems. To abate dye contamination, we here developed a novel magnetic porous CoFe 2 O 4 @MIL-53(Al) nanocomposite by incorporating magnetic CoFe 2 O 4 nanoparticles with MIL-53(Al) metal-organic framework. This nanocomposite possessed a surface area of 197.144 m 2  g -1 and a pore volume of 0.413 cm 3  g -1 . The effect of contact time (5-120 min), concentration (5-50 mg L -1 ), dosage (0.1-1.0 g L -1 ), and pH (2-10) on Congo red adsorption was clarified. CoFe 2 O 4 @MIL-53(Al) could remove 95.85% of Cong red dye from water with an accelerated kinetic rate of 0.6544 min -1 within 10 min. The kinetic and isotherm models showed the predominance of Bangham and Temkin. According to Langmuir, the maximum uptake capacities of CoFe 2 O 4 @MIL-53(Al), CoFe 2 O 4 , and MIL-53(Al) adsorbents were 43.768, 17.982, and 15.295 mg g -1 , respectively. CoFe 2 O 4 @MIL-53(Al) was selected to optimize Cong red treatment using Box-Behnken experimental design. The outcomes showed that CoFe 2 O 4 @MIL-53(Al) achieved the highest experimental uptake capacity of 35.919 mg g -1 at concentration (29.966 mg L -1 ), time (14.926 min), and dosage (0.486 g L -1 ). CoFe 2 O 4 @MIL-53(Al) could treat dye mixture (methylene blue, methyl orange, Congo red, malachite green, and crystal violet) with an outstanding removal efficiency of 81.24% for 30 min, and could be reused up to five cycles. Therefore, novel recyclable and stable CoFe 2 O 4 @MIL-53(Al) is recommended to integrate well with real dye treatments systems., Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Can Tho city in the Mekong Delta is in the top ten areas affected by climate change. Therefore, assessing climate change impacts, social and economic activities require proposed solutions to respond to climate change. This study aims to (i) apply the MIKE 11 model (Hydrodynamic module and Advection-Dispersion module) to simulate the impacts of climate change scenarios on water resources in Can Tho city; (ii) calculate water balance in Can Tho city; and (iii) suggest climate change adaptation plan for sustainable social-economic activities of the city. The results show that when the rainfall changes due to climate change, the flow rate tends to decrease at high tide and increase at low tide. When the sea level rises due to climate change, the flow rate tends to increase at high tide and decrease at low tide. For 2030, the flow will decrease up to 15.6% and 14.3% at the low tide period for RCP 2.6 and RCP 8.5 compared to the present, respectively. The flow will increase up to 63.5% and 58.9% at the high tide period for RCP 2.6 and RCP 8.5 compared to the present, respectively. The water demand evaluation shows that the water resource reserve in Can Tho city meets water demands in current and future scenarios under climate change. While rainwater and groundwater can provide enough water in the rainy season, the city has to use surface water during the dry season due to a lack of rainwater. Of these, agriculture contributes the most water demands (85%). Eight adaptation measures to climate change for Can Tho city are developed from 2021 to 2050., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Green synthesis of nanoparticles using plant extracts minimizes the usage of toxic chemicals or energy. Here, we concentrate on the green synthesis of nanoparticles using natural compounds from plant extracts and their applications in catalysis, water treatment and agriculture. Polyphenols, flavonoid, rutin, quercetin, myricetin, kaempferol, coumarin, and gallic acid in the plant extracts engage in the reduction and stabilization of green nanoparticles. Ten types of nanoparticles involving Ag, Au, Cu, Pt, CuO, ZnO, MgO, TiO 2 , Fe 3 O 4 , and ZrO 2 with emphasis on their formation mechanism are illuminated. We find that green nanoparticles serve as excellent, and recyclable catalysts for reduction of nitrophenols and synthesis of organic compounds with high yields of 83-100% and at least 5 recycles. Many emerging pollutants such as synthetic dyes, antibiotics, heavy metal and oils are effectively mitigated (90-100%) using green nanoparticles. In agriculture, green nanoparticles efficiently immobilize toxic compounds in soil. They are also sufficient nanopesticides to kill harmful larvae, and nanoinsecticides against dangerous vectors of pathogens. As potential nanofertilizers and nanoagrochemicals, green nanoparticles will open a revolution in green agriculture for sustainable development., Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest., (Copyright © 2022 Elsevier B.V. All rights reserved.)

This research explores the influences of selfish personalities of the Dark Triad on start-up intention and motives based on a sample of 400 university students in Vietnam, discovering mixed effects of narcissism, psychopathy, and Machiavellianism. A high level of narcissism and Machiavellianism leads to high start-up intention. There is a negative relationship of Machiavellianism with pro-social motive and a positive association with selfish entrepreneurship. In addition, narcissism is positively associated with pro-social start-up motives. This study has found no effect of psychopathy but a positive link to selfish entrepreneurial motivation. Implications have been suggested for educators and investors., Competing Interests: Competing interestsThe authors declare that they have no competing interests., (© The Author(s) 2022.)

Because many engineered nanoparticles are toxic, there is a need for methods to fabricate safe nanoparticles such as plant-based nanoparticles. Indeed, plant extracts contain flavonoids, amino acids, proteins, polysaccharides, enzymes, polyphenols, steroids, and reducing sugars that facilitate the reduction, formation, and stabilization of nanoparticles. Moreover, synthesizing nanoparticles from plant extracts is fast, safe, and cost-effective because it does not consume much energy, and non-toxic derivatives are generated. These nanoparticles have diverse and unique properties of interest for applications in many fields. Here, we review the synthesis of metal/metal oxide nanoparticles with plant extracts. These nanoparticles display antibacterial, antifungal, anticancer, and antioxidant properties. Plant-based nanoparticles are also useful for medical diagnosis and drug delivery., Competing Interests: Conflict of interestThe authors declare that there are no conflicts of interest., (© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.)

Chloramphenicol is a broad-spectrum bacterial antibiotic used against conjunctivitis, meningitis, plague, cholera, and typhoid fever. As a consequence, chloramphenicol ends up polluting the aquatic environment, wastewater treatment plants, and hospital wastewaters, thus disrupting ecosystems and inducing microbial resistance. Here, we review the occurrence, toxicity, and removal of chloramphenicol with emphasis on adsorption techniques. We present the adsorption performance of adsorbents such as biochar, activated carbon, porous carbon, metal-organic framework, composites, zeolites, minerals, molecularly imprinted polymers, and multi-walled carbon nanotubes. The effect of dose, pH, temperature, initial concentration, and contact time is discussed. Adsorption is controlled by π-π interactions, donor-acceptor interactions, hydrogen bonding, and electrostatic interactions. We also discuss isotherms, kinetics, thermodynamic data, selection of eluents, desorption efficiency, and regeneration of adsorbents. Porous carbon-based adsorbents exhibit excellent adsorption capacities of 500-1240 mg g -1 . Most adsorbents can be reused over at least four cycles., Competing Interests: Conflict of interestThe authors declare that there are no conflict of interest., (© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.)

Development of novel wound dressing materials having the ability to prevent bacterial infections and capable of accelerating the tissue regeneration process is utmost important, since the wounds in patients can cause severe health issues. In the present work, we synthesized novel N-succinyl chitosan nanoparticles (N-SuC NPs) films and tested their antimicrobial, cytotoxicity, and in vitro and in vivo wound healing activity. N-SuC NPs were synthesized by ionic gelation method, and subsequently N-SuC NPs films were prepared by solution casting method using synthesized N-SuC NPs. The prepared N-SuC NPs films showed significant antimicrobial activity against Escherichia coli and Staphylococcus aureus with a minimum inhibitory concentration of 6 mg/mL and <8 mg/mL, respectively. The biocompatibility and the in vitro wound healing activity of N-SuC NPs films were analyzed using human dermal fibroblast (HDF) cells. In vivo cutaneous wound healing of the N-SuC NPs film was investigated using the Wister rat model, and the studies showed that the N-SuC NPs film significantly accelerated the wound healing process by inducing more blood vessels formation and tissue granulation. The experimental results showed that synthesized N-SuC NPs film had excellent antimicrobial, cytotoxicity and wound healing activity, indicating that it could be used in biomedical applications., (Copyright © 2021. Published by Elsevier B.V.)

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health concern. The development of vaccines with high immunogenicity and safety is crucial for controlling the global COVID-19 pandemic and preventing further illness and fatalities. Here, we report the development of a SARS-CoV-2 vaccine candidate, Nanocovax, based on recombinant protein production of the extracellular (soluble) portion of the spike (S) protein of SARS-CoV-2. The results showed that Nanocovax induced high levels of S protein-specific IgG and neutralizing antibodies in three animal models: BALB/c mouse, Syrian hamster, and a non-human primate ( Macaca leonina ). In addition, a viral challenge study using the hamster model showed that Nanocovax protected the upper respiratory tract from SARS-CoV-2 infection. Nanocovax did not induce any adverse effects in mice ( Mus musculus var. albino) and rats ( Rattus norvegicus ). These preclinical results indicate that Nanocovax is safe and effective., Competing Interests: All authors except TTL, DCV and LKHN were employed by Nanogen Pharmaceutical Biotechnology Joint Stock Company (JSC). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Tran, May, Ung, Nguyen, Nguyen, Dinh, Doan, Tran, Khong, Nguyen, Hua, Nguyen, Ha, Phan, Nguyen, Bui, Tu, Nguyen, Le, Dong, Huynh, Ho, Le, Truong, Pham, Luong, Y, Cao, Nguyen, Le, Vuong, Nguyen and Do.)

The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd 2+ , Pb 2+ ) from water. Furthermore, two novel intelligent models, such as teaching-learning-based optimization (TLBO)-artificial neural network (ANN), and TLBO-support vector regression (SVR), named as TLBO-ANN and TLBO-SVR models, respectively, were proposed to predict the Cd 2+ and Pb 2+ absorption efficiencies from water using the NaHWP absorbent. Databases used, including 53 experiments for Pb 2+ absorption and 56 experiments for Cd 2+ absorption from water, under the catalysis of different conditions, such as initial concentration of Pb 2+ and Cd 2+ , solution pH, adsorbent weight, and contact time. Subsequently, the TLBO-ANN and TLBO-SVR models were developed and applied to predict the efficiencies of Cd 2+ and Pb 2+ absorption from water, aiming to evaluate the role as well as the effects of different conditions on the absorption efficiencies using the NaHWP absorbent. The standalone ANN and SVM models were also taken into consideration and compared with the proposed hybrid models (i.e., TLBO-ANN and TLBO-SVR). The results showed that the NaHWP detected in a Kaolin mine (Vietnam) with 70% nanotubular halloysites is a potential adsorbent for water treatment to eliminate heavy metals from water. The two novel hybrid models proposed, i.e., TLBO-ANN and TLBO-SVR, also yielded the dominant performances and accuracies in predicting the Cd 2+ and Pb 2+ absorption efficiencies from water, i.e., RMSE = 1.190 and 1.102, R 2  = 0.951 and 0.957, VAF = 94.436 and 95.028 for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Pb 2+ absorption efficiency from water; RMSE = 3.084 and 3.442, R 2  = 0.971 and 0.965, VAF = 96.499 and 96.415 for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Cd 2+ absorption efficiency from water. Furthermore, the validation results also demonstrated these findings in practice through 23 experiments with the accuracies of 98.3% and 98.37% for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Pb 2+ absorption efficiency from water; the accuracies of 98.3% and 97.46% for the TLBO-ANN and TLBO-SVR models, respectively, in predicting the Cd 2+ absorption efficiency from water. Besides, solution pH was evaluated as the most critical parameter that can be adjusted to enhance the performance of the absorption of the heavy metals in this study. By using the NaHWP absorbent and the novel proposed intelligent models developed, heavy metals can be eliminated entirely from water, providing pure water/clean freshwater without any risk of adverse health effects for the short term or long term., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Background: Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has caused a pandemic of pneumonia spreading around the world, leading to serious threats to public health and attracting enormous attention. There is an urgent need for sensitive diagnostic testing implementation to control and manage SARS-CoV-2 in public health laboratories. The quantitative reverse transcription PCR (RT-qPCR) assay is the gold standard method, but the sensitivity and specificity of SARS-CoV-2 testing are dependent on a number of factors., Methods: We synthesized RNA based on the genes published to estimate the concentration of inactivated virus samples in a biosafety level 3 laboratory. The limit of detection (LOD), linearity, accuracy, and precision were evaluated according to the bioanalytical method validation guidelines., Results: We found that the LOD reached around 3 copies/reaction. Furthermore, intra-assay precision, accuracy, and linearity met the accepted criterion with an RSD for copies of less than 25%, and linear regression met the accepted R 2 of 0.98., Conclusions: We suggest that synthesized RNA based on the database of the NCBI gene bank for estimating the concentration of inactivated virus samples provides a potential opportunity for reliable testing to diagnose coronavirus disease 2019 (COVID-19) as well as limit the spread of the disease. This method may be relatively quick and inexpensive, and it may be useful for developing countries during the pandemic era. In the long term, it is also applicable for evaluation, verification, validation, and external quality assessment., Competing Interests: The authors have no conflicts of interest., (Copyright © 2021 Hoang Quoc Cuong et al.)

Due to globalization expansion, corporate social responsibility (CSR) is no longer an unfamiliar concept in emerging markets. In the case of Vietnam, its implementation will be influenced by several factors, including ethical leadership. Drawing upon the stakeholder theory, this study develops and tests a serial mediation model to explain how CSR and firm reputation can connect ethical leadership to enhanced firm performance. The PLS-SEM results from survey data collected from 653 mid- and top-level managers from large companies in Vietnam indicate that ethical leadership positively influences CSR, which, in turn, results in enhanced firm reputation and firm performance. This study contributes to research on the intersection between CSR and leadership in the context of emerging markets. This study also provides some managerial implications for Vietnamese firms striving to promote ethical leadership to achieve CSR outcomes., Competing Interests: The authors declare no conflict of interest., (© 2021 The Author(s).)

Magnetic magnetite (Fe₃O₄) nanoparticles with average sizes of 5.11, 10.53, and 14.76 nm were synthesized by the chemical co-precipitation method. The surface area of Fe₃O₄ nanoparticles (average size of 5.11 nm) had the largest value of 167 m²/g. The adsorption capacity for removing arsenic (As(V)) from water at 3 ppm concentration was investigated by atomic absorption spectroscopy. Results showed that the As(V) adsorption capacity of Fe₃O₄ was dependent on particle size. The maximum absorption efficiency ( H max ) reached 99.02%, the equilibrium time was 30 min; the maximum Langmuir isotherm adsorption capacity was 14.46 mg/g with Fe₃O₄ nanoparticle an average size of 5 nm. The results indicate that reducing the size of Fe₃O₄ nanoparticles is a promised way for As(V) ion removal from water and wastewater treatment.

In this work, we chose small intestine submucosa (SIS) as a drug carrier because SIS possesses good biocompatibility, non-immunogenic property and bio-resorbability, and performed electrospinning for preparation of nanofiber sheets (NS). For the preparation of drug-loaded electrospun SIS nanofiber sheets as a drug carrier, we used poly(ε-caprolactone- ran -l-lactide) (PCLA) copolymers to improve the electrospinning performance of SIS. The electrospinning of SIS and PCLA provided the electrospun SIS/PCLA (S/P)-nanofiber sheet (S/P-NS) with adjustable thickness and areas. The electrospun S/P-NS showed different porosities, pore sizes, diameters and tensile strengths depending on the ratios between SIS and PCLA. The electrospun S/P-NS was used as a drug carrier of the dexamethasone (Dex) and silver sulfadiazine (AgS) drug related to anti-inflammation. Dex-loaded S/P-NS and AgS-loaded S/P-NS was successfully fabricated by the electrospinning. In the in vitro and in vivo release, we successfully confirmed the possibility for the sustained release of Dex and AgS from the Dex-S/P-NS and AgS-S/P-NS for three weeks. In addition, the sustained Dex and AgS release suppressed the macrophage infiltration. Collectively, we achieved feasible development of SIS nanofiber sheets for a sustained Dex and AgS delivery system.

Herein, we have successfully synthesized a novel N-Succinyl chitosan/gold nanocomposite (N-SuC/Au NC) using N-SuC and gold(III) chloride, and investigated the biocompatibility and antifungal activity. The synthesized N-SuC/Au NC was characterized by UV-visible spectroscopy, X-ray diffraction, field emission scanning electron microscope, and inductively coupled plasma atomic emission spectroscopy. The N-SuC/Au NC exhibited a strong inhibition effect towards pathogenic Candida albicans. Morphological analysis revealed the destruction of C. albicans cell membrane due to N-SuC/Au NC treatment. The in vitro and in vivo toxicity of N-SuC/Au NC was analyzed with HEK293T mammalian cells and zebrafish larvae, respectively. The synthesized N-SuC/Au NC demonstrated no cytotoxicity towards HEK293T cells up to 1200 μg/mL concentration. The survival rate of the zebrafish larvae at 120 hpf, was found as 100% up to 1200 μg/mL of N-SuC/Au NC exposure. The in vivo studies further confirmed the inhibitory effects of N-SuC/Au NC on the formation of C. albicans hyphae in infected zebrafish muscle tissue., Competing Interests: Declaration of competing interest All the authors in the manuscript will decelerated that no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)

In this study, soil-to-plant transfer factor and annual organ equivalent dose due to ingestion of natural radionuclides in 13 popular food crop samples in Ho Chi Minh city, Vietnam were estimated. The obtained data show that the radioactive elements transported from soil to plants play an essential role as indicators for the nutritional needs of plant and the ability to accumulate radioisotopes and heavy metal elements for environmental decontamination. It is found that B. alba and C. gigantean is useful for decontamination of high content potassium in soil, otherwise, P. fruticosa and C. gigantean may be used for soil with high concentration of 210 Pb and 226 Ra. In addition, biological effects of the plant ingestion in human body were assessed. The doses due to ingestion of food crop samples varied from organ to organ, depending on the organotrophic properties of the radionuclides. For examples, equivalent dose for 40 K in large intestine is higher than other organs. In contrast, equivalent dose for 238 U, 226 Ra, 210 Pb and 232 Th were mostly at bone surface. In general, the obtained dose values of lower than the average value recommended by UNSCEAR for food crop ingestion pose no threat to the public's health. However, close investigations are needed in the near future., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Background: There is a shortage of chemical reagents for severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) diagnosis and a surge of SARS-CoV-2 cases, especially in limited-resource settings. Therefore, the combination of an optimal assay kit is necessary., Methods: We compared the ability to screen SARS-CoV-2 among three primer-probe sets in two different master mixes, Invitrogen™ SuperScript™ III One-Step RT-PCR and LightCycler Multiplex RNA Virus Master., Results: The assay with TIB-Molbiol, IDT, and Phu Sa sets for LightCycler Multiplex RNA Virus Master or Invitrogen™ SuperScript™ III One-Step RT-PCR showed positive results from a single reaction of triplicate in the three days of 4.8 copies per reaction. R squared and amplification efficiency were 0.97 and ranged from 107 to 108%, respectively., Conclusions: Our findings indicated that TIB-Molbiol, IDT, and Phu Sa primer-probe sets could be beneficial for the laboratory screening of SARS-CoV-2 by RT-qPCR assay of E gene. There is a need to consider the combination of these reagent sets as a new strategy to increase the testing capacity of screening programs for COVID-19., Competing Interests: The authors have no conflicts of interest., (Copyright © 2020 Hoang Quoc Cuong et al.)

Background: Heavy metal contamination and related risks for the environment and human health are matters of increasing concern., Methods: The levels of 4 heavy metals (Cr, Cd, Pb, and As) were evaluated in 2 water types (surface and well), 4 types of seafood (tiger shrimp, stuffed snail, snake-head fish, and catfish), and 27 types of vegetables (12 leafy vegetables, 4 pea plants, 4 tuber vegetables, and 7 herbs) that are commonly consumed in northern coastal communes located in Vietnam. Atomic absorption spectrometry was employed for quantification., Results: The mean concentrations of heavy metals detected in water, seafood, and vegetable samples exceeded the national permitted standards and World Health Organization (WHO) recommendation values by at least 2-fold, 2.5-fold, and 5-fold for surface water, vegetables, and well water, respectively. The concentrations of all 4 heavy metals detected in seafood samples were higher than the standards. The levels of heavy metals decreased with increasing distance between the sample collection point and the pollution source., Conclusions: This is the first report of heavy metal contamination of common sources of food and water in the northern coastal area of Vietnam. Significantly, the concentrations of heavy metals detected in study samples exceeded the regulatory limits. These results underscore the importance of continued monitoring and the development of intervention measures to ensure that the quality of food and water meets established standards and protects the health of the local population., Competing Interests: Declaration of conflicting interest:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2020.)

Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%-100% at follow-up, corresponding to seroconversion rates of 57%-93%. Seroconversion for heterotypic viruses was recorded in only 3%-23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD.

Local injection of methotrexate (MTX) has been widely used for caesarean scar pregnancy (CSP), but the optimal candidate remains undetermined. The aim of this study is to determine the risk factors associated with treatment failure among patients who received a single dose of local MTX. This is a retrospective cohort study. Clinical information was compared between treatment success vs. failure groups. Risk factors related to treatment failure were also investigated with multivariate analysis. Of 47 patients diagnosed with CSP, 30 received local MTX injection. The initial serum ß- human chorionic gonadotropin (hCG) level in the failure group was significantly higher than in the success group (p = 0.048), and the cut-off value was 47,000 mIU/ml. The rate of type 2 position of the gestational sac in the failure group was significantly higher than in the treatment success group (p = 0.031). A high initial serum ß-hCG level (≥ 47,000 mIU/ml) was identified as the independent risk factor for treatment failure (adjusted odds ratio = 21.9; 95% confidence interval = 1.3-383.1). Type 2 gestational sac position and a higher level of ß-hCG at diagnosis appear to be associated with poor outcomes after local injection of a single dose of MTX., Competing Interests: The authors have no conflicts of interest to declare.

Enteroviruses (EV), the major pathogens of hand, foot, and mouth disease (HFMD) and herpangina, affect millions of children each year. Most human enteroviruses cause self-limited infections except polioviruses, enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and several echoviruses (Echo) and coxsackieviruses (CV). Especially, EV-A71 has repeatedly caused large-scale outbreaks in the Asia-Pacific region since 1997. Some Asian countries have experienced cyclical outbreaks of severe EV-A71 infections and initiated development of EV-A71 vaccines. Five EV-A71 vaccine candidates have been clinically evaluated and three of them were approved for marketing in China. However, none of the China-approved products seek marketing approval in other countries. This situation supports a role for collaboration among Asian countries to facilitate clinical trials and licensure of EV-A71 vaccines. Additionally, enterovirus D68 outbreaks have been reported in the US and Taiwan currently and caused severe complications and deaths. Hence, an Asia-Pacific Network for Enterovirus Surveillance (APNES) has been established to estimate disease burden, understand virus evolution, and facilitate vaccine development through harmonizing laboratory diagnosis and data collection. Founded in 2017, the APNES is comprised of internationally recognized experts in the field of enterovirus in Asian countries working to raise awareness of this potentially fatal and debilitating disease. This article demonstrated the summaries of the first expert meeting, 2017 International Workshop on Enterovirus Surveillance and Vaccine Development, held by APNES in Taipei, Taiwan, March 2017., (Copyright © 2019.)

In recent years, serosurveillance has gained momentum as a way of determining disease transmission and immunity in populations, particularly with respect to vaccine-preventable diseases. At the end of 2017, the Oxford University Clinical Research Unit and the National Institute of Hygiene and Epidemiology held a meeting in Vietnam with national policy makers, researchers, and international experts to discuss current seroepidemiologic projects in Vietnam and future needs and plans for nationwide serosurveillance. This report summarizes the meeting and the plans that were discussed to set up nationwide serosurveillance in Vietnam.

A prospective, multicentre study was conducted in four sentinel surveillance hospitals to assess the trend and epidemiology of acute diarrhea caused by Rotavirus in Vietnam. During the period 2012-2015, a total 8,889 children under 5 years of age were enrolled in the surveillance, and 8689 stool samples were collected. Of these cases, Rotavirus was most common pathogen 46.7% (4054 cases); in which 26.6% (1117) rotavirus-positive stool samples were evaluated to identify genotypes. The proportion of rotavirus positive specimens decreased annually from 54.7% in 2012 to 36.6% in 2015. Rotavirus was detected year-round, but most rotavirus gastroenteritis cases (77.1%) occurred between December and May, corresponding to the rotavirus seasonality. It is found that the peaks varied by regions. Rotavirus positivities varied between the youngest and oldest age, but children 6-11 months old (38.8%) and 12-23 months old (38.4%) counted for most cases. A significant higher number of diarrhea within 24 hours (8.3 times, 95%CI: 8.1-8.4 times) and higher proportion of severe dehydration (12.9%) in Rotavirus positive group than that in Rotavirus negative group (7.7 times, 95%CI: 7.6-7.9 times; and 9.7%, respectively). A downtrend of prevalence of G1P[8] was observed from 82% in 2013 to 15% in 2015. However, G2P[4] was found in 5% of samples in 2012, 9% in 2013, 36% in 2014, and 28% in 2015. Rotavirus infection is the most important cause of acute diarrhea among hospitalized children in Vietnam, and a rotavirus vaccination program for children may significantly reduce this disease., (Copyright © 2018. Published by Elsevier Ltd.)

Background: Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephalitis in children across the Asia-Pacific region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. The relative differences in their evolution and epidemiology were examined within Vietnam and globally., Methods: A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to coestimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network., Results: Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specific Asian countries representing genogroup-specific sources of EV-A71 diversity., Conclusion: This study highlights a persistent transmission network of EV-A71, with specific Asian countries seeding other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance and detailed genetic and antigenic characterization., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)

As of 13 July 2016, 13 countries have reported fetal Zika virus (ZIKV) infection. Here we report a case of fetal ZIKV infection that resulted from an infection originating in Vietnam.

During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.