Search

Thua Nguyen Tran,1 Huu Dang Tran,2 Thanh Tung Tran-Huu,2 Duc Minh Tran,1 Quang Nhat Tran1 1Department of General Internal Medicine and Geriatrics, Hue Central Hospital, Hue City, Vietnam; 2Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue City, VietnamCorrespondence: Thua Nguyen Tran, Department of General Internal Medicine and Geriatrics, Hue Central Hospital, 16 Le Loi Street, Hue City, 530000, Vietnam, Tel +84903597695, Email tranthuanguyen23@gmail.comBackground: Metabolic syndrome is one of the most common public health concerns in the 21st century. Several previous studies have shown an association between increased serum ferritin levels and other components of metabolic syndrome and the risk of metabolic syndrome. They conclude that ferritin can be viewed as a predictor of metabolic syndrome risk. This study investigates some main features of metabolic syndrome and the serum ferritin levels in a Vietnamese adult cohort with metabolic syndrome.Methods: A descriptive cross-sectional study was conducted on 207 patients who were treated at the General Internal Medicine-Geriatric Department, Hue Central Hospital, from May 2018 to August 2020. Patients were divided into two groups: the study group (104 patients with metabolic syndrome) and the control group (103 patients without metabolic syndrome and no serum ferritin-mediated disease). The metabolic syndrome was diagnosed by a joint interim statement of the International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute/World Heart Federation/International Atherosclerosis Society/International Association for the Study of Obesity in 2009.Results: Hypertriglyceridemia–hypertension–hyperglycemia (50.9%) is the most common combination of metabolic syndrome components. The mean serum ferritin concentration was 391.62± 181.97ng/mL and 124.55± 63.95ng/mL in the metabolic syndrome and control groups, respectively. In the metabolic syndrome group, increased ferritin concentration accounted for 86.54% for men, the mean serum ferritin concentration was 453.064 ± 161.75ng/mL (increased ferritin concentration accounted for 96.15%) for women; the mean serum ferritin concentration was 330.17 ± 181.71 ng/mL (increased ferritin concentration accounted for 86.54%).Conclusion: The serum ferritin level is significantly increased in Vietnamese patients with metabolic syndrome.Keywords: metabolic syndrome, ferritin, hypertension

Immunotherapy, particularly CAR-T therapy has recently emerged as an innovator for cancer treatment. Gamma-irradiated K562 cells is a common and effective method to stimulated CAR-T cells prior to treatment. However, high cost and limited equipment of gamma-irradiation is drawback of this method. This requires the establishment of CAR-T-expanding alternatives, such as X-ray-irradiated K562 cells. X-ray irradiation was used to deactivate K562 cells. The post-irradiative cell survival was investigated by counting of the number of cells, staining with Trypan Blue and PI. FACS analysis was applied to detect the expression of cell surface markers. The production of CD19-CAR-T cells were executed from fresh blood donor by CD19-CAR-plasmid transfection, followed by the stimulation with X-ray-irradiated K562 feeder cells. The function of produced CAR-T cells was checked by their ability to kill Daudi cells. X-ray-irradiation inhibited the propagation and viability of K562 cells in a dose- and time-dependent manner. Interestingly, CAR-T-stimulating effectors were remained on the surface of X-ray-irradiated K562 cells. CD-19-CAR-T cells were produced successfully, suggested by number of CAR-positive cells in transfected and stimulated population, compared to un-transfected group. Lastly, our data showed that engineered CAR-T cells effectively killed Daudi cells. Our data demonstrated the efficacy of X-ray on deactivation K562 feeder cells which subsequently stimulated and expanded functional CAR-T cells. Thus, X-ray can be used as an alternative to inactivate K562 cells prior to using as a feeder of CAR-T cells.

Over the past years, there have been several studies on the hydrodynamic regime, beach erosion, and accretion at the Cua Dai beach in Hoi An city. However, there is still a lack of in-depth research on the effects of hydrodynamic factors on beach evolution in extreme weather conditions such as a storm event or during the Northeast monsoons, characterized by large waves mainly, especially. The wave set-up directly impacts on the evolution of upper beaches and coastal dunes, consequently causing beach erosion. This paper presents the results of nearshore wave propagation and transformation and the distribution of wave set-up during storms in the coastal area of Cua Dai, Hoi An, using the SWAN model and the XBEACH model. The models have been calibrated and validated using measured wave and water level data observed in the study area in October 2016. The simulation results have shown the overall picture of the influence of wave set-up on the morphology evolution of beach profiles in the study area.

VE1 is a monoclonal antibody detecting mutant BRAF V600E protein by immunohistochemistry (IHC) with a high concordance rate with molecular analysis in many cancers. Materials and methods: BRAF V600...

The reachability problem for timed automata asks if a given automaton has a run leading to an accepting state, and the liveness problem asks if the automaton has an infinite run that visits accepting states infinitely often. Both of these problems are known to be P space -complete. We show that if P ≠P space , the liveness problem is more difficult than the reachability problem; in other words, we exhibit a family of automata for which solving the reachability problem with the standard algorithm is in P but solving the liveness problem is P space -hard. This leads us to revisit the algorithmics for the liveness problem. We propose a notion of a witness for the fact that a timed automaton violates a liveness property. We give an algorithm for computing such a witness and compare it to existing solutions.

Objective: To evaluate the association between serum ferritin concentrations with BMI, lipid profile and atherosclerosis index in hypertensive patients. Subjects and methods: The study of 72 patients with hypertension are treated at the department of general internal geriatric Hue Central Hospital, patients were excluded diseases causing increased ferritin and measured weight, height, BMI, lipid profile testing and atherogenic index. Results: Ferritin in patients with overweight, obesity patients was higher (p

W-beam guardrails are the most widely used road safety barriers worldwide. They are used for protecting vehicle occupants on dangerous areas of roadways. The ability of Wbeam guardrails to absorb some of the crash energy reduces the risk of injury for vehicle occupants and limits deformation of impacting vehicles. Once the rail separates from the posts, the rail forms a redirection ribbon, guiding the vehicles away from the nearby hazard. Thus, the soil-post interaction in W-beam guardrails play a critical role in the manner in which errant vehicles interact with safety barriers. All road safety barriers used on European highways are designed according to the European standard EN 1317. This study applied the finite element code LS-DYNA for evaluating the safety performance of W-beam guardrail when the post rammed into various soil properties. Four crash test simulations were conducted for evaluating the crashworthiness of the W-beam guardrail according to European Standard EN 1317. The results have demonstrated that the soil properties does not affect the impact severity (ASI, THIV) but affects working width. Keywords-crashworthiness; EN1317; LS-DYNA; W-beam guardrail

W-beam guardrails are the most widely used road safety barriers worldwide. They are used for protecting vehicle occupants on dangerous areas of roadways. All road safety barriers used on European highways are designed according to the European standard EN 1317. Conventionally, such road safety barriers have the following dimensions: a 750-mm height from the top of the W-beam to the ground and a 1.33-, 2-, or 4-m post spacing. This study applied the finite element code LS-DYNA for evaluating the safety performance of an AG04-2.0 A-type barrier, which was designed using three post spacings and various rail heights, when impacted by a 900-kg small passenger car. Eight crash test simulations were conducted for evaluating the crashworthiness of the AG04-2.0 barrier according to the European Standard EN 1317. A baseline model was developed and validated against the existing crash test models. The results showed that the various post spacings (1.33, 2, and 4 m) and rail heights (600, 650, 700, 750 and 800 mm) enabled the AG04-2.0 barrier to withstand the impact of the 900-kg car, satisfying the EN 1317 criteria (i.e. TB11 test). The 2000-mm post spacing and 700-mm rail height were considered the optimal dimensions for AG04-2.0 road safety barriers.

This study applied the finite element code LS-DYNA for evaluating the crashworthiness of W-beam guardrail. Four crash test simulations were conducted for evaluating the safety performance of the W-beam guardrail with four different post configuration according to the European standard EN1317. The results showed that the best performance was demonstrated by the sigma-shaped posts and the I-shaped posts absorbed the lowest amount of impact energy. The optimal result was registered by the barrier with sigma-shaped posts, which demonstrated a lower ASI value and higher energy crash absorption than the other models did.