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14. Evaluation of the association between tetracycline-class antibiotic use in patients with acne and idiopathic intracranial hypertension risk: a population-level cohort study.

Author

Thang, Christopher J, Garate, David, O'Leary, ​Sean, Golovko, George, Wilkerson, Michael G, and Barbieri, John S

Subjects
*INTRACRANIAL hypertension, *ACNE, *HEALTH Insurance Portability & Accountability Act
Abstract

A population-based cohort study was conducted to evaluate the association between tetracycline-class antibiotic use in patients with acne and the risk of idiopathic intracranial hypertension (IIH). The study found that minocycline, a type of tetracycline-class antibiotic, was significantly associated with an increased risk of IIH compared to doxycycline and nonsystemic treatments. However, the study had limitations, such as the inability to control for external lifestyle factors and the potential for residual confounding. Further research is needed to generalize these findings, but the study provides valuable insight for clinicians and patients considering tetracycline-class antibiotic treatment for acne. [Extracted from the article]

Published
2024
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18. Isotretinoin exposure does not appear to be associated with risk of adverse male sexual health outcomes in acne patients.

Author

Thang, Christopher J., Garate, David, Golovko, George, and Barbieri, John S.

Subjects
*IMPOTENCE, *SEXUAL health, *ISOTRETINOIN, *TREATMENT effectiveness
Abstract

A study published in the International Journal of Dermatology found no apparent link between the use of isotretinoin, a medication for severe acne, and adverse male sexual health outcomes. The study analyzed data from a large healthcare network in the United States and used a cohort study design. The findings suggest that isotretinoin does not pose a significant risk to male sexual health. However, the study had limitations and further research is needed to evaluate sexual health outcomes in female patients. This study provides reassuring data for clinicians and patients. [Extracted from the article]

Published
2024
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23. Investigating the Impact of Community Volunteerism on the Mental Health of Medical Students

Author

Duncan, Sheina A., primary, Sperling, Gabriel L., additional, Moy, Matthan I., additional, Hansen, Regina, additional, Soudah, Chris K., additional, Rodriguez, Patrick, additional, Rego, Andrea, additional, Rojas, Vivian N., additional, Paul, Melody, additional, Robicheaux, Joseph A., additional, Chen, Carrie, additional, Thang, Christopher, additional, and Agana, Denny Fe G., additional

Published
2023
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25. Development of a Rapid Drop Test for Surface Quality Inspection

Author

Thang, Christopher Y. and Liew, Chin Kian

Subjects
Mechanical engineering not elsewhere classified
Abstract

In material bonding, the surface energy of the adherend can be an excellent predictor of adhesive bond strength. In this research, the use of the sessile drop test as a pre-bond inspection tool for bonded composite repairs was investigated. A portable goniometer suitable for a maintenance workshop in the aviation industry was designed and built. Dimethyl sulfoxide and water were used as testing fluids, dispensed in 3 ul quantities. Contact angles were measured using the spherical approximation for a range of surfaces which included samples that had been peel-plied, hand sanded, grit blasted and contaminated with silicone release agent. The surface energies of the samples were then evaluated using the Owens-Wendt and Girifalco-Good-Fowkes-Young (GGFY) methods. Although the GGFY method successfully distinguished contamination, difficulties arose when evaluating surface roughness. Peel-ply surfaces also had varying contact angles due to irregular droplet shapes. The Owens-Wendt method was also found to be inaccurate with only two test fluids although this is regarded as industry standard, It is for these reasons that traditional surface energy methods were considered impractical for a workshop environment. An alternate measurement parameter considered was the droplet diameter where the same testing fluids were imaged from the top instead. This measurement successfully differentiated contamination and also allowed the abrasion process to be determined. In addition, the degree of abrasion could be determined between grit blasted and untreated peel-ply surfaces. This test was found to be more accurate than the traditional surface energy techniques and has the potential to form part of a pre-bond surface certification process for bonded composite repairs.

Published
2023
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26. Granuloma annulare and the risk of autoimmune conditions: a multicentre retrospective cohort analysis.

Author

Garate, David, Thang, Christopher J, Schmidt, Madelyn, Ravanassa, Shayan, Jimenez, Antonio R, Ross, Lindy S, Golovko, George, Barbieri, John S, and Wilkerson, Michael G

Subjects
*HEALTH Insurance Portability & Accountability Act, *TYPE 1 diabetes, *NOSOLOGY, *AUTOIMMUNE thyroiditis, *SYSTEMIC lupus erythematosus, *POLYMYOSITIS, *ALOPECIA areata
Abstract

A study published in the British Journal of Dermatology examined the association between granuloma annulare (GA), an inflammatory skin condition, and various autoimmune conditions. The study analyzed data from the TriNetX Research Network, which included 88 healthcare organizations, and identified 53,505 patients with GA who were matched with a control group. The results showed that patients with GA had a significantly increased risk of systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus, and autoimmune thyroiditis. The study also found potential associations with systemic sclerosis and uveitis, but further research is needed to confirm these findings. The study provides valuable insight into the risk of autoimmune disorders in people with GA. [Extracted from the article]

Published
2024
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