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Your search keyword '"Tham, Ivan Weng-Keong"' showing total 33 results
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33 results on '"Tham, Ivan Weng-Keong"'

2. Are heart doses associated with survival in patients with non-small cell lung cancer who received post-operative thoracic radiotherapy?: A national population-based study

Author

Lee, Chia Ching, Chua, Gail Wan Ying, Zheng, Huili, Soon, Yu Yang, Foo, Ling Li, Thiagarajan, Anuradha, Yap, Swee Peng, Siow, Tian Rui, Ng, Wee Loon, Chua, Kevin Lee Min, Yip, Connie, Chia, Brendan Seng Hup, Ng, Yan Yee, Master, Zubin, Tan, Poh Wee, Tan, Yun Inn, Leong, Yuh Fun, Loria, Joan Faith Evacula, Vellayappan, Balamurugan, Koh, Wee Yao, Leong, Cheng Nang, Tey, Jeremy Chee Seong, Tham, Ivan Weng Keong, and Fong, Kam Weng

Published
2019
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7. Accuracy of 18F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a systematic review and meta-analysis

Author

Vellayappan Balamurugan A., Soon Yu Yang, Earnest Arul, Zhang Qing, Koh Wee Yao, Tham Ivan Weng Keong, and Lee Khai Mun

Subjects
nasopharyngeal carcinoma, pet/ct, staging, accuracy, meta-analysis, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Background. The specific role of 18F-flurodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in staging of nasopharyngeal carcinoma (NPC) remains to be validated. A systematic review and meta-analysis were performed to assess the accuracy of staging FDG-PET/CT for newly diagnosed NPC. Methods. We searched various biomedical databases and conference proceedings for relevant studies. We determined the pooled sensitivities and specificities, diagnostic odds ratios (DOR) and constructed summary receiver operating characteristic (SROC) curves using the hierarchical regression model. Results. 15 relevant studies including 851 patients were identified. Five addressed primary tumor (T), nine addressed regional lymph nodes (N) and seven addressed distant metastasis (M). The combined sensitivity estimate for FDG-PET/CT in T classification was 0.77 (95% confidence interval [CI] 0.59-0.95). For N classification, combined sensitivity was 0.84 (95% CI 0.76-0.91), specificity was 0.90 (95% CI 0.83-0.97), DOR was 82.4 (23.2-292.6) and Q*-index was 0.90. For M classification, the combined sensitivity estimate was 0.87 (95% CI 0.74-1.00), specificity was 0.98 (95% CI 0.96-1.00), DOR was 120.9 (43.0-340.0) and Q*-index was 0.89. Conclusion. FDG-PET/CT showed good accuracy in N and M but not T classification for newly diagnosed NPC. FDG-PET/CT, together with Magnetic resonance imaging (MRI) of the nasopharynx, should be part of the routine staging investigations

Published
2014
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33. Accuracy of 18F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a systematic review and meta-analysis.

Author

Vellayappan, Balamurugan A., Soon, Yu Yang, Earnest, Arul, Zhang, Qing, Koh, Wee Yao, Tham, Ivan Weng Keong, and Lee, Khai Mun

Subjects
NASOPHARYNX tumors, COMPUTED tomography, CONFIDENCE intervals, DATABASES, DIAGNOSTIC imaging, EVALUATION of medical care, MEDICAL technology, META-analysis, ONCOLOGY, RADIOGRAPHY, SERIAL publications, POSITRON emission tomography, TUMOR classification, ACQUISITION of data, DIAGNOSIS
Abstract

Background. The specific role of 18F-flurodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in staging of nasopharyngeal carcinoma (NPC) remains to be validated. A systematic review and meta-analysis were performed to assess the accuracy of staging FDG-PET/CT for newly diagnosed NPC. Methods. We searched various biomedical databases and conference proceedings for relevant studies. We determined the pooled sensitivities and specificities, diagnostic odds ratios (DOR) and constructed summary receiver operating characteristic (SROC) curves using the hierarchical regression model. Results. 15 relevant studies including 851 patients were identified. Five addressed primary tumor (T), nine addressed regional lymph nodes (N) and seven addressed distant metastasis (M). The combined sensitivity estimate for FDG-PET/CT in T classification was 0.77 (95% confidence interval [CI] 0.59-0.95). For N classification, combined sensitivity was 0.84 (95% CI 0.76-0.91), specificity was 0.90 (95% CI 0.83-0.97), DOR was 82.4 (23.2-292.6) and Q*-index was 0.90. For M classification, the combined sensitivity estimate was 0.87 (95% CI 0.74-1.00), specificity was 0.98 (95% CI 0.96-1.00), DOR was 120.9 (43.0-340.0) and Q*-index was 0.89. Conclusion. FDG-PET/CT showed good accuracy in N and M but not T classification for newly diagnosed NPC. FDG-PET/CT, together with Magnetic resonance imaging (MRI) of the nasopharynx, should be part of the routine staging investigations [ABSTRACT FROM AUTHOR]

Published
2014
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