Search

Made available in DSpace on 2021-06-25T10:36:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Background: Exercise is commonly recommended to control hyperglycemia, including during pregnancy. We conducted this study to understand the potential benefits and risks of exercise during pregnancy of women with diabetes. Specifically, we evaluated the effects of swimming on a diabetic rat during pregnancy and assayed maternal-fetal parameters. Methods: Diabetes was induced in the female newborn from Wistar rats by the streptozotocin administration on first postnatal day. At 110 days of life, after confirm mild symptoms of diabetes, the rats were mated and randomly distributed into four experimental groups (minimum of 13 animals/group): Control (C)—nondiabetic animals without swimming; Control and Exercise (CEx)—nondiabetic animals submitted to swimming; Mild Diabetic (MD)—diabetic animals without swimming; Mild Diabetic and Exercise (MDEx)—diabetic animals submitted to swimming. The swimming program was performed from day 7 to 21 of pregnancy. Maternal parameters were evaluated during the pregnancy period. On day 21 of pregnancy, the rats were sacrificed and maternal and fetal parameters analyzed. Results: There are no alterations in body weight, food consumption, water intake, and reproductive outcomes among the groups. The swimming program did not normalize maternal glycemia and other biochemical biomarkers. The diabetes and exercise combination increased organ weight. The fetuses born to these exercising diabetic rats had reduced fetal weight and increased skeletal anomalies (mainly incomplete ossification of sternebra). Conclusion: The intense swimming exercise imposed on female rats during pregnancy impaired maternal metabolic repercussions, contributing to intrauterine growth restriction and fetal skeletal anomalies. Laboratory of General Physiology and Reproductive Toxicology Institute of Biological and Health Sciences University Center of Araguaia Federal University of Mato Grosso (UFMT) Laboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Univ Estadual Paulista_Unesp Laboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Univ Estadual Paulista_Unesp

Materials and methods The experimental severe diabetes was induced in newborn female Wistar rats in the first day of birth by intravenous injection of Streptozotocin in a dose of 100 mg/Kg. In adult life (110 days) the rats were submitted to oral glucose tolerance test (OGTT) to confirm the moderate diabetes. After its confirmation, rats were mated and randomly assigned to 4 experimental groups (minimum n=13 animals/group): Control: non-diabetic pregnant rats without exercise (sedentary); Exercise: non-diabetic pregnant rats exposed to exercise; Diabetic: diabetic pregnant rats without exercise; Diabetic Exercise: diabetic pregnant rats exposed to exercise. The moderate intensity exercise program was swimming, from the 7th to 20th days of pregnancy. At day 21 of pregnancy, the rats were anesthetized and the uterus was removed. Fetuses were analyzed to external, visceral and skeletal anomalies. Analysis of variance followed by Tukey’s test was used to mean values and Fisher Exact test was used to proportions. Differences were considered statistically significant when p