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Your search keyword '"Thakur, Pratima Singh"' showing total 7 results
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7 results on '"Thakur, Pratima Singh"'

1. Diabetes, Diabetic Retinopathy, and Inflammatory Disorders.

Author

Sheemar, Abhishek, Goel, Pallavi, Thakur, Pratima Singh, Takkar, Brijesh, Kaur, Inderjeet, Rani, Padmaja K., Tyagi, Mudit, Basu, Soumyava, and Venkatesh, Pradeep

Subjects
EYE inflammation, ANTI-inflammatory agents, DIABETES, INSULIN resistance, RHEUMATOID arthritis, DIABETIC retinopathy
Abstract

This review summarizes the impact of systemic and ocular inflammatory disorders on diabetes mellitus (DM) and diabetic retinopathy (DR). Local inflammation is a key pathology in diabetic retinopathy (DR) and is also an evolving target for clinical therapy. The legacy effects of local inflammation at the intracellular level make DR a persistent self-driven vicious process. Ocular inflammation is accompanied as well as incited by systemic inflammation due to diabetes mellitus (DM) itself. Over the years, a multitude of studies have evaluated the impact of systemic inflammatory disorders (SIDs, like rheumatoid arthritis, lupus, psoriasis, etc.) and anti-inflammatory drugs prescribed for managing them on manifestations of DM. Recent studies have indicated increased insulin resistance to be a result of chronic inflammation, and the anti-inflammatory drugs to have a protective effect towards DM. Very few studies have evaluated the impact of SIDs on DR. Furthermore, the evidence from these studies is conflicting, and while local anti-inflammatory therapy has shown a lot of clinical potential for use in DR, the results of systemic anti-inflammatory therapies have been inconsistent. The impact of local ocular inflammation due to uveitis on DR is a crucial aspect that has not been evaluated well at present. Initial pre-clinical studies and small-sized clinical reports have shown a strong and positive relationship between the presence of uveitis and the severity of DR as well as its progression, while larger cross-sectional patient surveys have refuted the same. The long term impact of ocular inflammation due to uveitis on DR needs to be studied while adjusting for confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Diabetes, Diabetic Retinopathy, and Inflammatory Disorders

Author

Sheemar, Abhishek, primary, Goel, Pallavi, additional, Thakur, Pratima Singh, additional, Takkar, Brijesh, additional, Kaur, Inderjeet, additional, Rani, Padmaja K., additional, Tyagi, Mudit, additional, Basu, Soumyava, additional, and Venkatesh, Pradeep, additional

Published
2023
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3. Scleral Fixation of Intraocular Lens in Aphakic Eyes without Capsular Support: Description of a New Technique

Author

Behera, Umesh Chandra and Thakur, Pratima Singh

Subjects
Ophthalmology, genetic structures, posterior capsular rent, trans scleral lens fixation, aphakia, intraocular lens, Clinical Ophthalmology, lens deposits, sense organs, eye diseases, Original Research
Abstract

Umesh Chandra Behera, Pratima Singh Thakur Retina-Vitreous Service, L V Prasad Eye Institute, Bhubaneswar, 751024, Odisha, IndiaCorrespondence: Umesh Chandra BeheraRetina-Vitreous Service, L V Prasad Eye Institute, Patia, Bhubaneswar, 751024, Odisha, IndiaTel +91-674-3987100Fax +91-674-398 7130Email umeshcbehera@gmail.comPurpose: To study the efficacy and safety of a modified trans-scleral intraocular lens (IOL) fixation technique in aphakic eyes when performed by ophthalmologists in training.Methods: The study was conducted in an institutional setting that included 43 surgeries performed by surgeons training in small incision cataract surgeries. The data were analyzed for stability and position of IOL, refractive changes, best-corrected vision, and associated complications.Results: Mean age of the subjects was 53.8 ± 18.5yrs (range 6– 81yrs). Surgical aphakia (58.14%) was the most common cause. The corrected distance visual acuity improved significantly at six weeks (p = 0.0003). The mean residual spectacle correction was +0.74 ± 1.2D spherical equivalent (cylinder − 1.6± 1.5D at 84 ± 50°) at the 6th-month follow-up (24.35 ± 6.71wks). Lens tilt on ultrasound biomicroscopy (kappa 0.762; p < 0.001) and the IOL centration (kappa 0.411; p = 0.001), assessed by two independent masked observers, were satisfactory at the 6th-month visit. Transient postoperative vitreous hemorrhage was the most common complication (46.5%). Cellular deposits on the IOL surface (18.6%), cystoid macular edema (11.6%), subconjunctival haptic exposure (4.66%), and haptic slippage (2.33%) were the other complications.Conclusion: This method of trans-scleral IOL fixation is an effective rescue procedure for eyes with deficient capsular support when ophthalmologists perform in training.Keywords: aphakia, intraocular lens, posterior capsular rent, trans scleral lens fixation, lens deposits

Published
2021
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7. Scleral Fixation of Intraocular Lens in Aphakic Eyes without Capsular Support: Description of a New Technique

Author

Behera,Umesh Chandra, Thakur,Pratima Singh, Behera,Umesh Chandra, and Thakur,Pratima Singh

Abstract

Umesh Chandra Behera, Pratima Singh Thakur Retina-Vitreous Service, L V Prasad Eye Institute, Bhubaneswar, 751024, Odisha, IndiaCorrespondence: Umesh Chandra BeheraRetina-Vitreous Service, L V Prasad Eye Institute, Patia, Bhubaneswar, 751024, Odisha, IndiaTel +91-674-3987100Fax +91-674-398 7130Email umeshcbehera@gmail.comPurpose: To study the efficacy and safety of a modified trans-scleral intraocular lens (IOL) fixation technique in aphakic eyes when performed by ophthalmologists in training.Methods: The study was conducted in an institutional setting that included 43 surgeries performed by surgeons training in small incision cataract surgeries. The data were analyzed for stability and position of IOL, refractive changes, best-corrected vision, and associated complications.Results: Mean age of the subjects was 53.8 ± 18.5yrs (range 6– 81yrs). Surgical aphakia (58.14%) was the most common cause. The corrected distance visual acuity improved significantly at six weeks (p = 0.0003). The mean residual spectacle correction was +0.74 ± 1.2D spherical equivalent (cylinder − 1.6± 1.5D at 84 ± 50°) at the 6th-month follow-up (24.35 ± 6.71wks). Lens tilt on ultrasound biomicroscopy (kappa 0.762; p < 0.001) and the IOL centration (kappa 0.411; p = 0.001), assessed by two independent masked observers, were satisfactory at the 6th-month visit. Transient postoperative vitreous hemorrhage was the most common complication (46.5%). Cellular deposits on the IOL surface (18.6%), cystoid macular edema (11.6%), subconjunctival haptic exposure (4.66%), and haptic slippage (2.33%) were the other complications.Conclusion: This method of trans-scleral IOL fixation is an effective rescue procedure for eyes with deficient capsular support when ophthalmologists perform in training.Keywords: aphakia, intraocular lens, posterior capsular rent, trans scleral lens fixation, lens deposits

Published
2021

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