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2. Management of Patients With Kidney Disease in Need of Cardiovascular Catheterization: A Scientific Workshop Cosponsored by the National Kidney Foundation and the Society for Cardiovascular Angiography and Interventions

Author

Prasad, Anand, Palevsky, Paul M., Bansal, Shweta, Chertow, Glenn M., Kaufman, James, Kashani, Kianoush, Kim, Esther S.H., Sridharan, Lakshmi, Amin, Amit P., Bangalore, Sripal, Briguori, Carlo, Charytan, David M., Eng, Marvin, Jneid, Hani, Brown, Jeremiah R., Mehran, Roxana, Sarnak, Mark J., Solomon, Richard, Thakar, Charuhas V., Fowler, Kevin, and Weisbord, Steven

Published
2022
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3. Temporal trends of dialysis requiring acute kidney injury after orthotopic cardiac and liver transplant hospitalizations

Author

Nadkarni, Girish N, Chauhan, Kinsuk, Patel, Achint, Saha, Aparna, Poojary, Priti, Kamat, Sunil, Patel, Shanti, Ferrandino, Rocco, Konstantinidis, Ioannis, Garimella, Pranav S, Menon, Madhav C, and Thakar, Charuhas V

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Disease, Organ Transplantation, Digestive Diseases, Clinical Research, Transplantation, Kidney Disease, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Adolescent, Adult, Aged, Cohort Studies, Female, Heart Transplantation, Hospitalization, Humans, Liver Transplantation, Male, Middle Aged, Renal Dialysis, Retrospective Studies, Time Factors, Young Adult, Acute kidney injury, Cardiac transplant, Liver transplant, Mortality, Outcomes, Urology & Nephrology, Clinical sciences, Health services and systems, Nursing
Abstract

BackgroundThe epidemiology and outcomes of acute kidney injury (AKI) in prevalent non-renal solid organ transplant recipients is unknown.MethodsWe assessed the epidemiology of trends in acute kidney injury (AKI) in orthotopic cardiac and liver transplant recipients in the United States. We used the Nationwide Inpatient Sample to evaluate the yearly incidence trends (2002 to 2013) of the primary outcome, defined as AKI requiring dialysis (AKI-D) in hospitalizations after cardiac and liver transplantation. We also evaluated the trend and impact of AKI-D on hospital mortality and adverse discharge using adjusted odds ratios (aOR).ResultsThe proportion of hospitalizations with AKI (9.7 to 32.7% in cardiac and 8.5 to 28.1% in liver transplant hospitalizations; ptrend

Published
2017

8. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment

Author

Vijayan, Anitha, Faubel, Sarah, Askenazi, David J, Cerda, Jorge, Fissell, William H, Heung, Michael, Humphreys, Benjamin D, Koyner, Jay L, Liu, Kathleen D, Mour, Girish, Nolin, Thomas D, Bihorac, Azra, Group, American Society of Nephrology Acute Kidney Injury Advisory, Basu, Rajit K, Bhatt, Udayan Y, Connor, Michael J, Davidson, Alan J, de Caestecker, Mark P, Doi, Kent, Golestaneh, Ladan, Mour, Girish K, Singh, Prabhleen, and Thakar, Charuhas V

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Kidney Disease, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Renal and urogenital, Acute Kidney Injury, Biomarkers, Clinical Trials as Topic, Decision Trees, Early Diagnosis, Humans, Insulin-Like Growth Factor Binding Proteins, Risk Assessment, Tissue Inhibitor of Metalloproteinase-2, Acute kidney injury, biomarker, [TIMP-2] x [IGFBP7], diagnosis, critically ill, tissue inhibitor of metalloproteinase 2, insulin-like growth factor binding protein 7, NephroCheck, early detection, risk assessment, renal dysfunction, decreased kidney function, American Society of Nephrology Acute Kidney Injury Advisory Group, [TIMP-2] × [IGFBP7], Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition and staging of AKI, early recognition remains challenging given that serum creatinine level is a marker, albeit imperfect, of kidney function and not kidney injury. Furthermore, the delay in increase in serum creatinine level after loss of glomerular filtration also prevents timely detection of decreased kidney function in patients with AKI. During the past decade, numerous clinical investigations have evaluated the utility of several biomarkers in the early diagnosis and risk stratification of AKI. In 2014, the US Food and Drug Administration approved the marketing of a test based on the combination of urine concentrations of tissue inhibitor of metalloproteinase 2 and insulin-like growth factor binding protein 7 ([TIMP-2] × [IGFBP7]) to determine whether certain critically ill patients are at risk for developing moderate to severe AKI. The optimal role of this biomarker in the diagnosis, management, and prognosis of AKI in different clinical settings requires further clarification. In this perspective, we summarize the biological actions of these 2 cell-cycle arrest biomarkers and present important considerations regarding the clinical application, interpretation, and limitations of this novel test for the early detection of AKI.

Published
2016

11. A clinical score to predict recovery in end-stage kidney disease due to acute kidney injury.

Author

Shah, Silvi, Ng, Jia H, Leonard, Anthony C, Harrison, Kathleen, Meganathan, Karthikeyan, Christianson, Annette L, and Thakar, Charuhas V

Subjects
CHRONIC kidney failure, ACUTE kidney failure, CONGESTIVE heart failure, ACUTE diseases, BODY mass index
Abstract

Background Acute kidney injury (AKI) is a major contributor to end-stage kidney disease (ESKD). About one-third of patients with ESKD due to AKI recover kidney function. However, the inability to accurately predict recovery leads to improper triage of clinical monitoring and impacts the quality of care in ESKD. Methods Using data from the United States Renal Data System from 2005 to 2014 (n  = 22   922), we developed a clinical score to predict kidney recovery within 90 days and within 12 months after dialysis initiation in patients with ESKD due to AKI. Multivariable logistic regressions were used to examine the effect of various covariates on the primary outcome of kidney recovery to develop the scoring system. The resulting logistic parameter estimates were transformed into integer point totals by doubling and rounding the estimates. Internal validation was performed. Results Twenty-four percent and 34% of patients with ESKD due to AKI recovered kidney function within 90 days and 12 months, respectively. Factors contributing to points in the two scoring systems were similar but not identical, and included age, race/ethnicity, body mass index, congestive heart failure, cancer, amputation, functional status, hemoglobin and prior nephrology care. Three score categories of increasing recovery were formed: low score (0–6), medium score (7–9) and high score (10–12), which exhibited 90-day recovery rates of 12%, 26% and 57%. For the 12-month scores, the low, medium and high groups consisted of scores 0–5, 6–8 and 9–11, with 12-month recovery rates of 16%, 33% and 62%, respectively. The internal validation assessment showed no overfitting of the models. Conclusion A clinical score derived from information available at incident dialysis predicts renal recovery at 90 days and 12 months in patients with presumed ESKD due to AKI. The score can help triage appropriate monitoring to facilitate recovery and begin planning long-term dialysis care for others. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Contributors

Author

Albright, Robert C., primary, Amerling, Richard, additional, Angeli, Paolo, additional, Angelotti, Maria Lucia, additional, Antonelli, Massimo, additional, Antoniotti, Riccardo, additional, Arulkumaran, Nishkantha, additional, Asfar, Pierre, additional, Ash, Stephen R., additional, Aucella, Filippo, additional, Aucella, Francesco, additional, Ave, Samuele, additional, Bagshaw, Sean M., additional, Balaraman, Vasanthi, additional, Baldwin, Ian, additional, Bargman, Joanne M., additional, Barletta, Gina-Marie, additional, Barletta, Jeffrey F., additional, Barnela, Shriganesh R., additional, Bayır, Hülya, additional, Beaulieu, Monica, additional, Bellasi, Antonio, additional, Bellomo, Rinaldo, additional, Beloncle, François, additional, Bhansali, Arjun, additional, Bihorac, Azra, additional, Billings, Frederic T., additional, Birk, Horst-Walter, additional, Bonilla-Reséndiz, Luis Ignacio, additional, Bouchard, Josée, additional, Bourke, Edmund, additional, Braitberg, George, additional, Brendolan, Alessandra, additional, Brocca, Alessandra, additional, Brophy, Patrick D., additional, Bucala, Richard, additional, Bunchman, Timothy E., additional, Burdmann, Emmanuel A., additional, Busse, Laurence W., additional, Caires, Renato Antunes, additional, Caironi, Pietro, additional, Camilla, Roberta, additional, Campos, Israel, additional, Canaud, Bernard, additional, Cantaluppi, Vincenzo, additional, Martinez, Maria P., additional, Capasso, Giovambattista, additional, Carcillo, Joseph A., additional, Carlesso, Eleonora, additional, Casino, Francesco G., additional, Castellano, Giuseppe, additional, Catania, Matteo, additional, Cawcutt, Kelly A., additional, Cerda, Jorge, additional, Charen, Elliot, additional, Chawla, Lakhmir S., additional, Chiaramonte, Stefano, additional, Chua, Horng-Ruey, additional, Cianciaruso, Bruno, additional, Ciceri, Paola, additional, Cieslak, Jacek, additional, Clark, William R., additional, Claure-Del Granado, Rolando, additional, Clementi, Anna, additional, Co, Ivan N., additional, Coelho, Fernanda Oliveira, additional, Conte, Ferruccio, additional, Corey, Howard E., additional, Cosmai, Laura, additional, Costalonga, Elerson Carlos, additional, Costamagna, Andrea, additional, Costanzo, Maria Rosa, additional, Cozzolino, Mario, additional, Cramer, Carl H., additional, Cravedi, Paolo, additional, Crepaldi, Carlo, additional, Creteur, Jacques, additional, Crew, R. John, additional, da Costa e Silva, Verônica Torres, additional, Davenport, Andrew, additional, Davies, Andrew R., additional, D'Costa, Rohit, additional, Dean, Dawson F., additional, Debiais, Charlotte, additional, de Cal, Massimo, additional, Dedhia, Paras, additional, de Grooth, Harm-Jan, additional, Dell'Aquila, Roberto, additional, Dellepiane, Sergio, additional, Dellinger, Richard Phillip, additional, Del Vecchio, Lucia, additional, Depner, Thomas A., additional, De Rosa, Silvia, additional, Deutschman, Clifford S., additional, Devarajan, Prasad, additional, Dewitte, A., additional, Di Iorio, Biagio R., additional, Di Lullo, Luca, additional, Di Micco, Lucia, additional, Di Nardo, Matteo, additional, Ding, Xiaoqiang, additional, D'Ippoliti, Fiorella, additional, Di Somma, Salvatore, additional, Doi, Kent, additional, Dries, David J., additional, Druml, Wilfred, additional, Duke, Graeme, additional, Durand, Francois, additional, Eadon, Michael T., additional, Eckstein, Devin, additional, Egi, Moritoki, additional, Eiam-Ong, Somchai, additional, Elbers, Paul W.G., additional, Elli, Francesca, additional, Elliott, Steve, additional, Emlet, David R., additional, Endre, Zoltan, additional, Evans, Roger G., additional, Fanelli, Vito, additional, Fattahi, Fatemeh, additional, Federspiel, Christine Kinggaard, additional, Ferrada, Marcela A., additional, Ferrari, Fiorenza, additional, Fiaccadori, Enrico, additional, Fiorentino, Marco, additional, Fisher, Caleb, additional, Flessner, Michael F., additional, Formica, Marco, additional, Forni, Lui G., additional, Francoz, Claire, additional, French, Craig, additional, Fuhrman, Dana Y., additional, Fumagalli, Giordano, additional, Galbusera, Miriam, additional, Gallieni, Maurizio, additional, Gammill, Hilary S., additional, Gao, Dayong, additional, Garzotto, Francesco, additional, Gatta, Giuseppe, additional, Genga, Kelly R., additional, Genovesi, Simonetta, additional, Genyk, Yuri S., additional, Geradin, Christel, additional, Gesualdo, Loreto, additional, Giavarina, Davide, additional, Giuliani, Anna, additional, Glezerman, Ilya G., additional, Goldstein, Stuart L., additional, Golper, Thomas A., additional, Gómez, Hernando, additional, Granata, Antonio, additional, Grandaliano, Giuseppe, additional, Grasselli, Giacomo, additional, Groeneveld, A.B. Johan, additional, Guerci, Philippe, additional, Gunnerson, Kyle J., additional, Harbord, Nikolas, additional, Harshman, Lyndsay A., additional, Hennessy, Anthony J., additional, Hill, Graham L., additional, Hobson, Charles, additional, Hohenstein, Bernd, additional, Honoré, Patrick M., additional, Horwitz, Edward, additional, Hosseinian, Leila, additional, Hoste, Eric A.J., additional, House, Andrew A., additional, Humes, H. David, additional, Husain-Syed, Faeq, additional, Ince, Can, additional, Ing, Todd S., additional, Jacobs, Rita, additional, Jaswal, Dharmvir, additional, Jeyabalan, Arun, additional, Joannes-Boyau, Olivier, additional, Joannidis, Michael, additional, Joyce, Emily, additional, Kane-Gill, Sandra L., additional, Kaplan, Lewis J., additional, Kashani, Kianoush, additional, Katz, Nevin, additional, Kellum, John A., additional, Khanna, Ramesh, additional, Kim-Campbell, Nahmah, additional, King, Joshua D., additional, Kirwan, Christopher J., additional, Kiss, Joseph E., additional, Klein, David, additional, Kotanko, Peter, additional, Krediet, Raymond T., additional, Kuhlmann, Martin K., additional, Kuiper, Jan Willem, additional, Lachance, Philippe, additional, Lameire, Norbert, additional, Langer, Thomas, additional, Lankadeva, Yugeesh R., additional, Laurin, Louis-Philippe, additional, Lazzeri, Elena, additional, Leblanc, Martine, additional, Lefebvre, Joannie, additional, Lentini, Paolo, additional, Leray-Moragués, Hélène, additional, Levin, Adeera, additional, Lew, Susie Q., additional, Liapis, Helen, additional, Liu, Kathleen D., additional, Livigni, Sergio, additional, Locatelli, Francesco, additional, Lorenzin, Anna, additional, Lu, Jian-Da, additional, Lu, Renhua, additional, Lysak, Nicholas, additional, Macedo, Etienne, additional, Madan, Niti, additional, Madore, François, additional, Maerz, Linda L., additional, Maiden, Matthew J., additional, Malhotra, Rakesh, additional, Marengo, Marita, additional, Mariano, Filippo, additional, Marik, Paul E., additional, Marini, John J., additional, Marino, Rossella, additional, Marshall, Mark R., additional, Mårtensson, Johan, additional, Matsuura, Ryo, additional, May, Clive N., additional, Mazzone, Patrizio, additional, McCauley, Jerry, additional, McCullough, Peter A., additional, McMahon, Blaithin A., additional, Mehta, Ravindra L., additional, Mele, Caterina, additional, Menon, Madhav, additional, Meola, Mario, additional, Mérouani, Aicha, additional, Meuwly, Jean-Yves, additional, Milla, Paola, additional, Misra, Madhukar, additional, Misra, Paraish S., additional, Mizock, Barry A., additional, Modi, Jwalant R., additional, Moeckel, Gilbert, additional, Molitoris, Bruce A., additional, Morabito, Santo, additional, Mucelli, Roberto Pozzi, additional, Murray, Patrick T., additional, Murugan, Raghavan, additional, Nadim, Mitra K., additional, Nair, Devika, additional, Nalesso, Federico, additional, Neri, Mauro, additional, Nguyen, Trung C., additional, Ni, Zhaohui, additional, Noris, Marina, additional, Novick, Tessa, additional, O'Horo, John C., additional, Okusa, Mark Douglas, additional, Opal, Steven M., additional, Opdam, Helen Ingrid, additional, Ostermann, Marlies, additional, Ottaviano, Emerenziana, additional, Oudemans-van Straaten, Heleen M., additional, Overgaard-Steensen, Christian, additional, Padalino, Massimo A., additional, Panichi, Vincenzo, additional, Parameswaran, Priyanka, additional, Patel, Samir S., additional, Payen, Didier, additional, Pea, Federico, additional, Peacock, W. Frank, additional, Peart, Sandrica Young, additional, Peerapornratana, Sadudee, additional, Pelosi, Paolo, additional, Peng, Zhi-Yong, additional, Perico, Norberto, additional, Peruzzi, Licia, additional, Pesce, Francesco, additional, Pesenti, Antonio, additional, Petrucci, Ilaria, additional, Pham, Phuong-Chi, additional, Pham, Phuong-Thu, additional, Phoon, Richard K.S., additional, Piano, Salvatore, additional, Pinsky, Michael R., additional, Piquilloud, Lise, additional, Pistolesi, Valentina, additional, Plank, Lindsay D., additional, Plötz, Frans B., additional, Podestá, Manuel Alfredo, additional, Porta, Camillo, additional, Pozzato, Marco, additional, Prencipe, Michele, additional, Prowle, John R., additional, Puthucheary, Zudin A., additional, Qu, Lirong, additional, Rachoin, Jean-Sebastien, additional, Radhakrishnan, Jai, additional, Ranieri, V. Marco, additional, Ratanarat, Ranistha, additional, Remuzzi, Giuseppe, additional, Resnick, Shelby, additional, Rewa, Oleksa G., additional, Ricci, Zaccaria, additional, Ridel, Christophe, additional, Rifai, Kinan, additional, Ring, Troels, additional, Rizo-Topete, Lilia M., additional, Roessler, Eric, additional, Romagnani, Paola, additional, Romagnoli, Stefano, additional, Ronco, Claudio, additional, Ronco, Federico, additional, Rosner, Mitchell H., additional, Rossetti, Emanuele, additional, Russell, James A., additional, Saab, Georges, additional, Sabatino, Alice, additional, Saboo, Sonali S., additional, Samoni, Sara, additional, Sappington, Penny Lynn, additional, Sartori, Marco, additional, Savige, Judy, additional, Schena, Francesco Paolo, additional, Schneider, Antoine Guillaume, additional, Schraverus, Pieter, additional, Schulte, Wibke, additional, Segoloni, Giuseppe, additional, Semler, Matthew W., additional, Sharma, Aashish, additional, Shaw, Andrew, additional, Sheth, Naitik, additional, Shukla, Ashutosh, additional, Siddall, Eric C., additional, Sievers, Theodore M., additional, Siew, Edward D., additional, Singbartl, Kai, additional, Singer, Mervyn, additional, Singh, Pooja, additional, Smith, Loren E., additional, Soni, Sachin S., additional, Soto, Mara Serrano, additional, Spapen, Herbert D., additional, Srisawat, Nattachai, additional, Srivastava, Ajay, additional, Stellin, Giovanni, additional, Symons, Jordan M., additional, Szamosfalvi, Balazs, additional, Tai, Kian Bun, additional, Takalkar, Unmesh V., additional, Teitelbaum, Isaac, additional, Tetta, Ciro, additional, Thakar, Charuhas V., additional, Tonon, Marta, additional, Trepiccione, Francesco, additional, Triulzi, Darrell, additional, Tushar, Chopra, additional, Uchino, Shigehiko, additional, Valika, Ali, additional, Van Biesen, Wim, additional, Vandenberghe, Wim, additional, Vanholder, Raymond, additional, Vanmassenhove, Jill, additional, Verbine, Anton, additional, Vergano, Marco, additional, Villa, Gianluca, additional, Villeneuve, Pierre-Marc, additional, Vincent, Jean-Louis, additional, Vinsonneau, Christophe, additional, Virzì, Grazia Maria, additional, Visconti, Federico, additional, Visvanathan, Ravindran, additional, Van Vong, Li, additional, Walmrath, Hans-Dieter, additional, Ward, Peter A., additional, Weir, Matthew A., additional, Wen, Xiaoyan, additional, Wendon, Julia, additional, Winchester, James Frank, additional, Wong, Adrian, additional, Woodhouse, Elke L., additional, Xue, Jun, additional, Yadav, Anju, additional, Yerram, Preethi, additional, Yessayan, Lenar, additional, Yeun, Jane Y., additional, Yu, Alex W., additional, Zaccaria, Marta, additional, Zacchia, Miriam, additional, Zachariah, Teena P., additional, Zamperetti, Nereo, additional, Zampieri, Fernando G., additional, Zanco, Pierluigi, additional, Zanella, Alberto, additional, Zanoli, Luca, additional, Zappitelli, Michael, additional, Zaragoza, Jose J., additional, Zarbock, Alexander, additional, Zaroccolo, Marta, additional, Zhang, Han, additional, and Zimmer, Andrea, additional

Published
2019
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17. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment

Author

Faubel, Sarah, Askenazi, David J., Basu, Rajit K., Bhatt, Udayan Y., Bihorac, Azra, Cerda, Jorge, Connor, Michael J., Jr., Davidson, Alan J., de Caestecker, Mark P., Doi, Kent, Fissell, William H., Golestaneh, Ladan, Heung, Michael, Humphreys, Benjamin D., Koyner, Jay L., Liu, Kathleen D., Mour, Girish K., Singh, Prabhleen, Thakar, Charuhas V., Vijayan, Anitha, Mour, Girish, and Nolin, Thomas D.

Published
2016
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19. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

Author

Reigle, James, Secic, Dina, Biesiada, Jacek, Wetzel, Collin, Shamsaei, Behrouz, Chu, Johnson, Zang, Yuanwei, Zhang, Xiang, Talbot, Nicholas J., Bischoff, Megan E., Zhang, Yongzhen, Thakar, Charuhas V., Gaitonde, Krishnanath, Sidana, Abhinav, Bui, Hai, Cunningham, John T., Zhang, Qing, Schmidt, Laura S., Linehan, W. Marston, Medvedovic, Mario, Plas, David R., Figueroa, Julio A. Landero, Meller, Jarek, and Czyzyk-Krzeska, Maria F.

Subjects
Smoking -- Health aspects, Carcinoma, Renal cell -- Development and progression -- Care and treatment, Cell metabolism -- Health aspects, Health care industry
Abstract

BACKGROUND. Clear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and includes several genetic subtypes with different prognoses. ccRCC is also characterized by distinctive metabolic reprogramming. Tobacco smoking (TS) is an established risk factor for ccRCC, with unknown effects on tumor pathobiology. METHODS. We investigated the landscape of ccRCCs and paired normal kidney tissues using integrated transcriptomic, metabolomic, and metallomic approaches in a cohort of white males who were long-term current smokers (LTS) or were never smokers (NS). RESULTS. All 3 Omics domains consistently identified a distinct metabolic subtype of ccRCCs in LTS, characterized by activation of oxidative phosphorylation (OXPHOS) coupled with reprogramming of the malate-aspartate shuttle and metabolism of aspartate, glutamate, glutamine, and histidine. Cadmium, copper, and inorganic arsenic accumulated in LTS tumors, showing redistribution among intracellular pools, including relocation of copper into the cytochrome c oxidase complex. A gene expression signature based on the LTS metabolic subtype provided prognostic stratification of The Cancer Genome Atlas ccRCC tumors that was independent of genomic alterations. CONCLUSION. The work identified the TS-related metabolic subtype of ccRCC with vulnerabilities that can be exploited for precision medicine approaches targeting metabolic pathways. The results provided rationale for the development of metabolic biomarkers with diagnostic and prognostic applications using evaluation of OXPHOS status. The metallomic analysis revealed the role of disrupted metal homeostasis in ccRCC, highlighting the importance of studying effects of metals from e- cigarettes and environmental exposures. FUNDING. Department of Defense, Veteran Administration, NIH, ACS, and University of Cincinnati Cancer Institute., Introduction Clear cell renal cell carcinoma (ccRCC) is characterized by loss of tumor suppressors localized to the short arm of chromosome 3, including the von Hippel Lindau gene (VHL), which [...]

Published
2021
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34. Hyperuricemia in a patient with Waldenström’s Macroglobulinemia: An innocent bystander?

Author

Smith, Zachary, Goyal, Pankaj, Pandya, Vrajesh, Thakar, Charuhas V, and Gudsoorkar, Prakash S

Abstract

Background: Paraproteins often cause factitious biochemical measurements by forming opaque precipitates with the test reagents and interfering with various automated assays. These interferences may be difficult to anticipate as they are intermittent and patient-specific. Increased IgM has been shown to result in the underestimation of uric acid levels and pseudo-hypouricemia; however, there are no reported cases of pseudo-hyperuricemia in the setting of paraproteinemia.Case presentation: We present a case of Waldenström’s Macroglobulinemia (WM), resulting in a marked elevation of the uric acid level in the absence of tumor lysis syndrome (TLS). On evaluation, it was noted that the elevation in the uric acid levels was spurious, potentially due to high IgM levels resulting in increased serum viscosity. Identifying actual and pseudo-abnormal laboratory results is critical to guide further workup and conserve scarce healthcare resources. The absence of other concomitant laboratory abnormalities and clinical symptoms should raise a suspicion of factitious results. In addition to uric acid, many other assays are affected by paraproteinemia, commonly including electrolytes, lipids, glucose, and liver function tests.

Published
2023
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41. sj-pdf-3-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-3-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
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42. sj-pdf-8-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-8-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
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43. sj-docx-2-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-2-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
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44. sj-docx-1-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
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45. sj-docx-3-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-3-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
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46. sj-pdf-4-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-4-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
Full Text
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47. sj-docx-4-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-4-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
Full Text
View/download PDF

48. sj-docx-5-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-5-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
Full Text
View/download PDF

49. sj-pdf-1-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
Full Text
View/download PDF

50. sj-docx-7-mpp-10.1177_23814683211056537 ��� Supplemental material for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study

Author

Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., and Sherman, Kenneth E.

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-7-mpp-10.1177_23814683211056537 for Incorporating Patients��� Values and Preferences Into Decision Making About Transplantation of HCV-Na��ve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Mark H. Eckman, Adeboye A. Adejare, Heather Duncan, E. Steve Woodle, Charuhas V. Thakar, Rita R. Alloway and Kenneth E. Sherman in MDM Policy & Practice

Published
2021
Full Text
View/download PDF

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