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2. Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers.

Author

Dodbiba, Lorin, Teichman, Jennifer, Fleet, Andrew, Thai, Henry, Starmans, Maud HW, Navab, Roya, Chen, Zhuo, Girgis, Hala, Eng, Lawson, Espin-Garcia, Osvaldo, Shen, Xiaowei, Bandarchi, Bizhan, Schwock, Joerg, Tsao, Ming-Sound, El-Zimaity, Hala, Der, Sandy D, Xu, Wei, Bristow, Robert G, Darling, Gail E, Boutros, Paul C, Ailles, Laurie E, and Liu, Geoffrey

Subjects
Esophagogastric Junction, Animals, Mice, Inbred NOD, Humans, Mice, Mice, SCID, Esophageal Neoplasms, Stomach Neoplasms, Xenograft Model Antitumor Assays, Inbred NOD, SCID, General Science & Technology
Abstract

The high morbidity and mortality of patients with esophageal (E) and gastro-esophageal junction (GEJ) cancers, warrants new pre-clinical models for drug testing. The utility of primary tumor xenografts (PTXGs) as pre-clinical models was assessed. Clinicopathological, immunohistochemical markers (p53, p16, Ki-67, Her-2/neu and EGFR), and global mRNA abundance profiles were evaluated to determine selection biases of samples implanted or engrafted, compared with the underlying population. Nine primary E/GEJ adenocarcinoma xenograft lines were further characterized for the spectrum and stability of gene/protein expression over passages. Seven primary esophageal adenocarcinoma xenograft lines were treated with individual or combination chemotherapy. Tumors that were implanted (n=55) in NOD/SCID mice had features suggestive of more aggressive biology than tumors that were never implanted (n=32). Of those implanted, 21/55 engrafted; engraftment was associated with poorly differentiated tumors (p=0.04) and older patients (p=0.01). Expression of immunohistochemical markers were similar between patient sample and corresponding xenograft. mRNA differences observed between patient tumors and first passage xenografts were largely due to loss of human stroma in xenografts. mRNA patterns of early vs late passage xenografts and of small vs large tumors of the same passage were similar. Complete resistance was present in 2/7 xenografts while the remaining tumors showed varying degrees of sensitivity, that remained constant across passages. Because of their ability to recapitulate primary tumor characteristics during engraftment and across serial passaging, PTXGs can be useful clinical systems for assessment of drug sensitivity of human E/GEJ cancers.

Published
2015

4. Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

Author

Dodbiba, Lorin, Teichman, Jennifer, Fleet, Andrew, Thai, Henry, Sun, Bin, Panchal, Devang, Patel, Devalben, Tse, Alvina, Chen, Zhuo, Faluyi, Olusola O, Renouf, Daniel J, Girgis, Hala, Bandarchi, Bizhan, Schwock, Joerg, Xu, Wei, Bristow, Robert G, Tsao, Ming-Sound, Darling, Gail E, Ailles, Laurie E, El-Zimaity, Hala, and Liu, Geoffrey

Published
2013
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5. Correction: Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma

Author

Teichman, Jennifer, primary, Dodbiba, Lorin, additional, Thai, Henry, additional, Fleet, Andrew, additional, Morey, Trevor, additional, Liu, Lucy, additional, McGregor, Madison, additional, Cheng, Dangxiao, additional, Chen, Zhuo, additional, Darling, Gail, additional, Brhane, Yonathan, additional, Song, Yuyao, additional, Espin-Garcia, Osvaldo, additional, Xu, Wei, additional, Girgis, Hala, additional, Schwock, Joerg, additional, MacKay, Helen, additional, Bristow, Robert, additional, Ailles, Laurie, additional, and Liu, Geoffrey, additional

Published
2019
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6. Does health and medical research consider geographic factors affecting study participants: a retrospective snapshot analysis of 11 leading journals

Author

Wark, Stuart, primary, Hardikar, Natasha, additional, Wensing, Martin, additional, Lau, Bonnie, additional, Anugerah, Joanne, additional, Wallace, Gary, additional, Powell, Destiny, additional, Thai, Henry, additional, Zhou, Jessica, additional, Senthinathan, Alycia, additional, and Le, Ann, additional

Published
2019
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7. Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma

Author

Teichman, Jennifer, primary, Dodbiba, Lorin, additional, Thai, Henry, additional, Fleet, Andrew, additional, Morey, Trevor, additional, Liu, Lucy, additional, McGregor, Madison, additional, Cheng, Dangxiao, additional, Chen, Zhuo, additional, Darling, Gail, additional, Brhane, Yonathan, additional, Song, Yuyao, additional, Espin-Garcia, Osvaldo, additional, Xu, Wei, additional, Girgis, Hala, additional, Schwock, Joerg, additional, MacKay, Helen, additional, Bristow, Robert, additional, Ailles, Laurie, additional, and Liu, Geoffrey, additional

Published
2018
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9. EQ-5D Health Utility Scores: Data from a Comprehensive Canadian Cancer Centre

Author

Naik, Hiten, primary, Howell, Doris, additional, Su, Susie, additional, Qiu, Xin, additional, Brown, M. Catherine, additional, Vennettilli, Ashlee, additional, Irwin, Margaret, additional, Pat, Vivien, additional, Solomon, Hannah, additional, Wang, Tian, additional, Hon, Henrique, additional, Eng, Lawson, additional, Mahler, Mary, additional, Thai, Henry, additional, Ho, Valerie, additional, Xu, Wei, additional, Seung, Soo Jin, additional, Mittmann, Nicole, additional, and Liu, Geoffrey, additional

Published
2016
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10. Abstract B15: Second-hand smoke (SHS) and smoking cessation in non-tobacco related cancers

Author

Eng, Lawson, primary, Qiu, Xin, additional, Su, Jie, additional, Brown, M Catherine, additional, Irwin, Margaret, additional, Pringle, Dan, additional, Naik, Hiten, additional, Niu, Chongya, additional, Mahler, Mary, additional, Hon, Henrique, additional, Tiessen, Kyoko, additional, Charow, Rebecca, additional, Thai, Henry, additional, Ho, Valerie, additional, Pat, Vivien, additional, Herzog, Lindsay, additional, Ho, Anthea, additional, Jones, Jennifer M., additional, Howell, Doris, additional, Goldstein, David P., additional, Giuliani, Meredith E., additional, Xu, Wei, additional, Selby, Peter, additional, and Liu, Geoffrey, additional

Published
2015
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11. Stage specific health utility index scores of Canadian cancer patients.

Author

Naik, Hiten, primary, Howell, Doris, additional, Su, Jie, additional, Qiu, Xin, additional, Brown, Catherine, additional, Vennettilli, Ashlee, additional, Irwin, Margaret, additional, Pat, Vivien, additional, Solomon, Hannah, additional, Wang, Tian, additional, Hon, Henrique, additional, Eng, Lawson, additional, Mahler, Mary, additional, Thai, Henry, additional, Ho, Valerie, additional, Xu, Wei, additional, Seung, Soo Jin, additional, Mittmann, Nicole, additional, and Liu, Geoffrey, additional

Published
2015
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12. Canadian cancer site-specific health utility values: Creating the basis for measuring value and costs of therapy.

Author

Naik, Hiten, primary, Howell, Doris, additional, Qiu, Xin, additional, Brown, Catherine, additional, Vennettilli, Ashlee, additional, Irwin, Margaret, additional, Pat, Vivien, additional, Solomon, Hannah, additional, Wang, Tian, additional, Hon, Henrique, additional, Eng, Lawson, additional, Mahler, Mary, additional, Tiessen, Kyoko, additional, Thai, Henry, additional, Ho, Valerie, additional, Pringle, Dan, additional, Xu, Wei, additional, Seung, Soo Jin, additional, Mittmann, Nicole, additional, and Liu, Geoffrey, additional

Published
2014
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13. Involving clinic patients in systematic symptom reporting to improve cancer care: Exploring prevalence of sleep disturbances (SD) and fatigue (FAT).

Author

Irwin, Margaret, primary, Brown, Catherine, additional, Vennettilli, Ashlee, additional, Eng, Lawson, additional, Zarrin, Aein, additional, Dobriyal, Aditi, additional, Chen, Linda, additional, Mirshams, Maryam, additional, Patel, Deval, additional, Hon, Henrique, additional, Pat, Vivien, additional, Ho, Anthea, additional, Solomon, Hannah, additional, Tiessen, Kyoko, additional, Thai, Henry, additional, Ho, Valerie, additional, Mahler, Mary, additional, Xu, Wei, additional, Liu, Geoffrey, additional, and Howell, Doris, additional

Published
2014
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14. Effect of physical activity (PA) perceptions in cancer survivors on PA behaviors: Helping health care providers improve patient communication.

Author

Naik, Hiten, primary, Liu, Geoffrey, additional, Qiu, Xin, additional, Pringle, Dan, additional, Brown, Catherine, additional, Eng, Lawson, additional, Mahler, Mary, additional, Hon, Henrique, additional, Tiessen, Kyoko, additional, Thai, Henry, additional, Ho, Valerie, additional, Gonos, Christina, additional, Charow, Rebecca, additional, Pat, Vivien, additional, Irwin, Margaret, additional, Herzog, Lindsay, additional, Ho, Anthea, additional, Jones, Jennifer M., additional, Xu, Wei, additional, and Howell, Doris, additional

Published
2014
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15. Using tablet technology in routine patient-reported outcome measure surveys to improve cancer quality care: A patient acceptability assessment.

Author

Pat, Vivien, primary, Brown, Catherine, additional, Vennettilli, Ashlee, additional, Zarrin, Aein, additional, Dobriyal, Aditi, additional, Chen, Linda, additional, Mirshams, Maryam, additional, Patel, Deval, additional, Hon, Henrique, additional, Irwin, Margaret, additional, Ho, Anthea, additional, Solomon, Hannah, additional, Tiessen, Kyoko, additional, Mahler, Mary, additional, Ho, Valerie, additional, Thai, Henry, additional, Eng, Lawson, additional, Xu, Wei, additional, Howell, Doris, additional, and Liu, Geoffrey, additional

Published
2014
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16. Assessing the utility of a patient-reported screener question to detect fatigue symptoms: Improving the quality of systematic symptom measurement in clinical practice.

Author

Tomasini, Pascale, primary, Brown, Catherine, additional, Vennettilli, Ashlee, additional, Zarrin, Aein, additional, Dobriyal, Aditi, additional, Chen, Linda, additional, Mirshams, Maryam, additional, Patel, Deval, additional, Irwin, Margaret, additional, Ho, Valerie, additional, Ho, Anthea, additional, Pat, Vivien, additional, Solomon, Hannah, additional, Thai, Henry, additional, Mahler, Mary, additional, Xu, Wei, additional, Howell, Doris, additional, and Liu, Geoffrey, additional

Published
2014
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17. Socioeconomic status and lifestyle behaviors in cancer survivors.

Author

Naik, Hiten, primary, Eng, Lawson, additional, Brown, Catherine, additional, Qiu, Xin, additional, Pringle, Dan, additional, Mahler, Mary, additional, Hon, Henrique, additional, Tiessen, Kyoko, additional, Thai, Henry, additional, Ho, Valerie, additional, Gonos, Christina, additional, Charow, Rebecca, additional, Pat, Vivien, additional, Irwin, Margaret, additional, Herzog, Lindsay, additional, Ho, Anthea, additional, Xu, Wei, additional, Jones, Jennifer M., additional, Howell, Doris, additional, and Liu, Geoffrey, additional

Published
2014
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18. Social and perceptual influences on alcohol consumption in cancer survivors.

Author

Eng, Lawson, primary, Su, Jie, additional, Qiu, Xin, additional, Brown, M Catherine, additional, Naik, Hiten, additional, Pringle, Dan, additional, Mahler, Mary, additional, Hon, Henrique, additional, Tiessen, Kyoko, additional, Thai, Henry, additional, Ho, Valerie, additional, Gonos, Christina, additional, Pat, Vivien, additional, Irwin, Margaret, additional, Herzog, Lindsay, additional, Ho, Anthea, additional, Xu, Wei, additional, Jones, Jennifer M., additional, Howell, Doris, additional, and Liu, Geoffrey, additional

Published
2014
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20. Cancer Patients? Willingness to Routinely Complete the EQ-5D Instrument at Clinic Visits.

Author

Naik H, Qiu X, Brown MC, Mahler M, Hon H, Tiessen K, Thai H, Ho V, Gonos C, Charow R, Pat V, Irwin M, Herzog L, Ho A, Xu W, Howell D, Seung SJ, Liu G, and Mittmann N

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Socioeconomic Factors, Young Adult, Neoplasms psychology, Quality of Life, Surveys and Questionnaires
Abstract

Background: Health utility (HU) scores play an essential role in pharmacoeconomic analyses. Routine clinical administration of the EuroQol-5 Dimensions (EQ-5D) can allow for HU and health related quality of life (HRQOL) assessments in the real-world setting., Objectives: The primary goals of this study were to evaluate whether patients were willing to complete the EQ-5D instrument on a routine basis and which clinical or demographic factors influence this willingness., Methods: 618 adult cancer survivors across multiple cancer disease sites at the Princess Margaret Cancer Centre completed an acceptability survey after completing the EQ-5D instrument., Results: The mean (SD) EQ-5D score was 0.81 (0.15). Among those surveyed, 88% reported that the EQ-5D was easy to complete. 91% took under 5 minutes and 88% were satisfied with its length. 85% were satisfied with the types of questions asked on the EQ-5D. Importantly, 92% reported that they would complete the EQ-5D, even if it were used solely for research purposes; 73% agreed with the notion of completing it regularly at their clinic visits. Patients with lower EQ-5D scores (p=0.0006), and non-Caucasians (p=0.0024; 60% willing) were less willing to complete the instrument on a regular basis. Curability of tumour, disease site, age, and gender did not influence willingness., Conclusions: The majority of cancer patients across disease sites are willing to complete the EQ-5D instrument regularly, even if it were solely for research purposes, but up to 39% declined participation in the first place.

Published
2016
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