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30 results on '"Thadathil, Nidheesh"'

4. Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

Author

Bhaskaran, Shylesh, Kumar, Gaurav, Thadathil, Nidheesh, Piekarz, Katarzyna M., Mohammed, Sabira, Lopez, Sergio Dominguez, Qaisar, Rizwan, Walton, Dorothy, Brown, Jacob L., Murphy, Ashley, Smith, Nataliya, Saunders, Debra, Beckstead, Michael J., Plafker, Scott, Lewis, Tommy L., Jr., Towner, Rheal, Deepa, Sathyaseelan S., Richardson, Arlan, Axtell, Robert C., and Van Remmen, Holly

Published
2023
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8. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model

Author

Ohene-Marfo, Phoebe, primary, Nguyen, Hoang Van M., additional, Mohammed, Sabira, additional, Thadathil, Nidheesh, additional, Tran, Albert, additional, Nicklas, Evan H., additional, Wang, Dawei, additional, Selvarani, Ramasamy, additional, Farriester, Jacob W., additional, Varshney, Rohan, additional, Kinter, Michael, additional, Richardson, Arlan, additional, Rudolph, Michael C., additional, and Deepa, Sathyaseelan S., additional

Published
2024
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12. Fig. S7 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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13. Supplementary Table 1 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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14. Supplementary Table 2 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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15. Data from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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16. Supplementary Data Legends from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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17. Supplementary Table 3 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, primary, Ohene-Marfo, Phoebe, primary, Tran, Albert L., primary, Van Der Veldt, Michael, primary, Georgescu, Constantin, primary, Oh, Sangphil, primary, Nicklas, Evan H., primary, Wang, Dawei, primary, Haritha, Nair Hariprasad, primary, Luo, Wenyi, primary, Janknecht, Ralf, primary, Miller, Benjamin F., primary, Wren, Jonathan D., primary, Freeman, Willard M., primary, and Deepa, Sathyaseelan S., primary

Published
2023
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18. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, additional, Ohene-Marfo, Phoebe, additional, Tran, Albert L., additional, Van Der Veldt, Michael, additional, Georgescu, Constantin, additional, Oh, Sangphil, additional, Nicklas, Evan H., additional, Wang, Dawei, additional, Haritha, Nair Hariprasad, additional, Luo, Wenyi, additional, Janknecht, Ralf, additional, Miller, Benjamin F., additional, Wren, Jonathan D., additional, Freeman, Willard M., additional, and Deepa, Sathyaseelan S., additional

Published
2023
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19. Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Author

Mohammed, Sabira, primary, Thadathil, Nidheesh, additional, Tran, Albert L, additional, Van Der Veldt, Michael, additional, Georgescu, Constantin, additional, Haritha, Nair H, additional, Ohene-Marfo, Phoebe, additional, Oh, Sangphil, additional, Nicklas, Evan H, additional, Wang, Dawei, additional, Luo, Wenyi, additional, Janknecht, Ralf, additional, Miller, Benjamin F, additional, Wren, Jonathan D., additional, Freeman, Willard, additional, and Deepa, Sathyaseelan S, additional

Published
2022
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20. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

Author

Thadathil, Nidheesh, primary, Selvarani, Ramasamy, additional, Mohammed, Sabira, additional, Nicklas, Evan H., additional, Tran, Albert L., additional, Kamal, Maria, additional, Luo, Wenyi, additional, Brown, Jacob L., additional, Lawrence, Marcus M., additional, Borowik, Agnieszka K., additional, Miller, Benjamin F., additional, Van Remmen, Holly, additional, Richardson, Arlan, additional, and Deepa, Sathyaseelan S., additional

Published
2022
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27. Enzymatic extraction and characterisation of a thermostable collagen from swim bladder of rohu (Labeo rohita)

Author

Pal, Gaurav Kumar, Thadathil, Nidheesh, Karadka, Govindaraju, Jyoti, and Puthanveetil Velappan, Suresh

Subjects
Fish Proteins, Carps, Air Sacs, Spectroscopy, Fourier Transform Infrared, Microscopy, Electron, Scanning, Animals, Electrophoresis, Polyacrylamide Gel, Amino Acids, Collagen Type I, Protein Structure, Secondary
Abstract

The fish swim bladder is considered as a potential source of realistic collagen. Currently, processing of the Indian major carp rohu (Labeo rohita) generates an enormous quantity of non-edible by-products, including swim bladders, which are discarded as waste with no commercial value. In the present study, collagen was prepared from rohu swim bladder and its physicochemical and fibril-forming capacities were assessed.The collagen isolated from rohu swim bladder was characterised as type I, containing α1 and α2 chains with triple helical structure by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, fourier transform infrared spectroscopy and amino acid analysis. The extracted collagen denaturation temperature was found to be 42.16 °C by differential scanning calorimetry analysis and also exhibited a high solubility in the presence of low NaCl concentrations (0-0.6 mol LThe rohu swim bladder type I collagen was successfully extracted using an enzymatic method with a yield of 465.2 g kg

Published
2015

29. Statistical optimization of solid state fermentation conditions for the enhanced production of thermoactive chitinases by mesophilic soil fungi using response surface methodology and their application in the reclamation of shrimp processing by-products

Author

Thadathil, Nidheesh, primary, Kuttappan, Anil Kumar Peedikathara, additional, Vallabaipatel, Elakkiyaselvi, additional, Kandasamy, Maheswari, additional, and Velappan, Suresh Puthanveetil, additional

Published
2013
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30. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model.

Author

Ohene-Marfo P, Nguyen HVM, Mohammed S, Thadathil N, Tran A, Nicklas EH, Wang D, Selvarani R, Farriester J, Varshney R, Kinter M, Richardson A, Rudolph M, and Deepa SS

Abstract

Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its role is unclear due to diverse mouse models and inhibition strategies. In our study, we inhibited necroptosis by targeting mixed lineage kinase domain like pseudokinase (MLKL), the terminal effector of necroptosis, in a high-fat, high-fructose, high-cholesterol (HFHFrHC) mouse model of diet-induced MAFLD mouse model. Despite HFHFrHC diet upregulating MLKL (2.5-fold), WT mice livers showed no increase in necroptosis markers or associated proinflammatory cytokines. Surprisingly, Mlkl -/- mice experienced exacerbated liver inflammation without protection from diet-induced liver damage, steatosis, or fibrosis. In contrast, Mlkl +/- mice showed significant reduction in these parameters that was associated with elevated Pparα and Pparγ levels. Both Mlkl -/- and Mlkl +/- mice on HFHFrHC diet resisted diet-induced obesity, attributed to increased beiging, enhanced oxygen consumption and energy expenditure due to adipose tissue, and exhibited improved insulin sensitivity. These findings highlight the tissue specific effects of MLKL on the liver and adipose tissue, and suggest a dose-dependent effect of MLKL on liver pathology.

Published
2024
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