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251 results on '"Texier, Isabelle"'

26. Photophysics and photochemistry of a water-soluble C (sub)60 dendrimer: fluorescence quenching by halides and photoinduced oxidation of I (super)-

Author

Texier, Isabelle, Berberan-Santos, Mario N., Fedorov, Aleksandre, Brettreich, Michael, Schonberger, Hubert, Hirsch, Andreas, Leach, Sydney, and Bensasson, Rene V.

Subjects
Chemistry, Physical and theoretical -- Research, Fluorescence -- Physiological aspects, Oxidation-reduction reaction -- Physiological aspects, Photochemical research -- Analysis, Water -- Physiological aspects, Solution (Chemistry) -- Physiological aspects, Halides -- Physiological aspects, Iodides -- Physiological aspects, Chemicals, plastics and rubber industries
Published
2001

29. From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Author

Cicha, Iwona, Chauvierre, Cédric, Texier, Isabelle, Cabella, Claudia, Metselaar, Josbert M., Szebeni, János, Alexiou, Christoph, Rouzet, François, Storm, Gert, Stroes, Erik, Bruce, Donald, MacRitchie, Neil, Maffia, Pasquale, and Letourneur, Didier

Abstract

Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicomponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

Published
2018

32. From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Author

Afd Pharmaceutics, Pharmaceutics, Cicha, Iwona, Chauvierre, Cédric, Texier, Isabelle, Cabella, Claudia, Metselaar, Josbert M, Szebeni, János, Dézsi, László, Alexiou, Christoph, Rouzet, François, Storm, Gert, Stroes, Erik, Bruce, Donald, MacRitchie, Neil, Maffia, Pasquale, Letourneur, Didier, Afd Pharmaceutics, Pharmaceutics, Cicha, Iwona, Chauvierre, Cédric, Texier, Isabelle, Cabella, Claudia, Metselaar, Josbert M, Szebeni, János, Dézsi, László, Alexiou, Christoph, Rouzet, François, Storm, Gert, Stroes, Erik, Bruce, Donald, MacRitchie, Neil, Maffia, Pasquale, and Letourneur, Didier

Published
2018

33. Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers.

Author

Gauthier, Laura, Chevallet, Mireille, Bulteau, Francois, Thépaut, Michel, Delangle, Pascale, Fieschi, Franck, Vivès, Corinne, Texier, Isabelle, Deniaud, Aurélien, and Gateau, Christelle

Subjects
LECTINS, GALACTOSE, SURFACE plasmon resonance, ENDOCYTOSIS, SMALL molecules, LIPIDS, SPATIAL arrangement
Abstract

Liver is the main organ for metabolism but is also subject to various pathologies, from viral, genetic, cancer or metabolic origin. There is thus a crucial need to develop efficient liver-targeted drug delivery strategies. Asialoglycoprotein receptor (ASGPR) is a C-type lectin expressed in the hepatocyte plasma membrane that efficiently endocytoses glycoproteins exposing galactose (Gal) or N-acetylgalactosamine (GalNAc). Its targeting has been successfully used to drive the uptake of small molecules decorated with three or four GalNAc, thanks to an optimisation of their spatial arrangement. Herein, we assessed the biological properties of highly stable nanostructured lipid carriers (NLC) made of FDA-approved ingredients and formulated with increasing amounts of GalNAc. Cellular studies showed that a high density of GalNAc was required to favour hepatocyte internalisation via the ASGPR pathway. Interaction studies using surface plasmon resonance and the macrophage galactose-lectin as GalNAc-recognising lectin confirmed the need of high GalNAc density for specific recognition of these NLC. This work is the first step for the development of efficient nanocarriers for prolonged liver delivery of active compounds. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Comparative analysis of nanosystems’ effects on human endothelial and monocytic cell functions

Author

Matuszak, Jasmin, primary, Dörfler, Philipp, additional, Lyer, Stefan, additional, Unterweger, Harald, additional, Juenet, Maya, additional, Chauvierre, Cédric, additional, Alaarg, Amr, additional, Franke, Danielle, additional, Almer, Gunter, additional, Texier, Isabelle, additional, Metselaar, Josbert M., additional, Prassl, Ruth, additional, Alexiou, Christoph, additional, Mangge, Harald, additional, Letourneur, Didier, additional, and Cicha, Iwona, additional

Published
2018
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43. Novel nanostructured lipid carriers dedicated to nucleic acid delivery for RNAi purposes

Author

Jonathan Bruniaux, Sulpice, Eric, Mittler, Frédérique, Menneteau, Mathilde, Bastogne, Thierry, Texier, Isabelle, Gidrol, Xavier, Navarro, Fabrice, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Biology, genetics and statistics (BIGS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Bastogne, Thierry

Subjects
[STAT.AP]Statistics [stat]/Applications [stat.AP], [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [STAT.AP] Statistics [stat]/Applications [stat.AP], [SPI.MAT] Engineering Sciences [physics]/Materials, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience; RNA interference discovery has opened up new fields of study, including the understanding of dysregulation occurring in pathogenesis, especially in cancerogenesis. Through this mechanism, the controlled specific down-regulation improves the identification of gene function involved in a biological mechanism and their contribution in an altered phenotype. In this way, high-throughput screening (HTS) of RNAi has emerged as a potent tool in order to study a large number of gene functions for the identification of new biomarkers and/or therapeutic targets. However, HTS requires for that purpose generic carriers with highly efficient transfection. Recently, progresses have been made regarding the design of non-viral vectors (lipids, peptides, polymers) as delivery agents. The efficiency and specificity of gene-based expression of siRNA have been improved, while at the same time reducing toxicity. Among these carriers, lipid-based agents, already used as commercial reagents for in vitro transfection, are considered as a promising approach for siRNA delivery.Here, we have developed novel nanostructured lipid carriers through a design of experiment approach which promote high transfection efficiency in several human cell lines. These lipid nanoparticles present an outstanding colloidal stability, whereas their cationic shell promotes ready- to-use features for fast and simple complexation with nucleic acids by electrostatic bonds establishment, without inducing cytotoxicity. As evidenced by gel retardation assay, complexation is stable over time, even in cell culture media, enabling thus stable transfection efficiency for all samples in a protocol of large-scale screening. Compared to the commercially available lipoplexes, these lipid nanoemulsions offer the possibility to combine several functions into a unique carrier, such as fluorescent particle tracking through the encapsulation of lipophilic dyes and/or the co-delivery of other drugs. Thereby, the distribution monitoring into cells with nanocarriers entrapping lipophilic cyanine derivatives demonstrates an improved internalization of nucleic acids. Furthermore, preliminary experiments performed on primary cells in culture demonstrated also an improved transfection compared to commercially available lipoplexes, opening thus the way for RNAi screening in that cells recognised as hard to transfectBesides, ligand moieties can be grafted onto the particle surface in order to selectively target a specific subset of cells. Such cationic lipid nanodroplets open new avenues in the development of high throughput RNAi screening as well as their translation to clinics.

Published
2014

44. SWAN-iCare project: Towards smart wearable and autonomous negative pressure device for wound monitoring and therapy

Author

Texier, Isabelle, Xydis, Sotirios, Soudris, Dimitrios, Marcoux, Pierre, Pham, Pascale, Muller, Marie, Correvon, Marc, Dudnik, Gabriela, Voirin, Guy, Kristenssen, Jan, Laurenza, Massimo, Raptopoulos, Andreas, Saxby, Carl, Navarro, Thierry, DI FRANCESCO, Fabio, Salvo, Pietro, Romanelli, Marco, and Lymberopoulos, Leonidas

Subjects
Computer Networks and Communications, Bio sensors, Collagen, Negative pressure, Remote surveillance, Wound management, Computer Science Applications1707 Computer Vision and Pattern Recognition, Electrical and Electronic Engineering, Health Informatics
Published
2014

45. Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing

Author

Matuszak, Jasmin, primary, Baumgartner, Jens, additional, Zaloga, Jan, additional, Juenet, Maya, additional, da Silva, Acarília Eduardo, additional, Franke, Danielle, additional, Almer, Gunter, additional, Texier, Isabelle, additional, Faivre, Damien, additional, Metselaar, Josbert M, additional, Navarro, Fabrice P, additional, Chauvierre, Cédric, additional, Prassl, Ruth, additional, Dézsi, László, additional, Urbanics, Rudolf, additional, Alexiou, Christoph, additional, Mangge, Harald, additional, Szebeni, János, additional, Letourneur, Didier, additional, and Cicha, Iwona, additional

Published
2016
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46. An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors

Author

Karageorgis, Anastassia, primary, Dufort, Sandrine, additional, Sancey, Lucie, additional, Henry, Maxime, additional, Hirsjärvi, Samuli, additional, Passirani, Catherine, additional, Benoit, Jean-Pierre, additional, Gravier, Julien, additional, Texier, Isabelle, additional, Montigon, Olivier, additional, Benmerad, Mériem, additional, Siroux, Valérie, additional, Barbier, Emmanuel L., additional, and Coll, Jean-Luc, additional

Published
2016
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47. Development and characterization of targeted vectors for tumor imaging and treatment

Author

Sancey, Lucie, Dufort, Sandrine, Gravier, Julien, Valero, Garcia, Hirsjärvi, Samuli, Josserand, Veronique, Boturyn, D, Dumy, P, Benoît, Jean-Pierre, Texier, Isabelle, Aouacheria, A, Coll, Jean-Luc, Univ Angers, Okina, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Département de Chimie Moléculaire (DCM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Joseph Fourier - Grenoble 1 (UJF), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

48. Optical imaging and Cancer: From mice to man

Author

Coll, Jean-Luc, Dufort, Sandrine, Sancey, Lucie, Josserand, Véronique, Kéramidas, M, Righini, C, Texier, Isabelle, Roux, Stéphane, Passirani-Malleret, Catherine, Dumy, P, Boturyn, D, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), UF Cancérologie Biologique et Biothérapie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Economie et Sociologie des Transports (INRETS/DEST), Institut National de Recherche sur les Transports et leur Sécurité (INRETS), Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Département de Chimie Moléculaire (DCM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Joseph Fourier - Grenoble 1 (UJF), Univ Angers, Okina, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
2010

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