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3,055 results on '"Tetrahydrofolate Dehydrogenase genetics"'

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1. Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase.

2. Evolution of Pfdhps and Pfdhfr mutations before and after adopting seasonal malaria chemoprevention in Nanoro, Burkina Faso.

3. Characterization of the Three DHFRs and K65P Variant: Enhanced Substrate Affinity and Molecular Dynamics Analysis.

4. Enzoology: understanding enzyme interactions and epistasis in the cell.

5. folA thyA knockout E. coli as a suitable surrogate model for evaluation of antifolate sensitivity against PfDHFR-TS.

6. A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda.

7. Expression patterns of folate metabolism-related enzymes in the bovine oviduct: estrous cycle-dependent modulation and responsiveness to folic acid.

8. Viral communities in a pH>10 serpentinite-like environment: insight into diversity and potential roles in modulating the microbiomes by bioactive vitamin B 9 synthesis.

9. Synonymous and non-synonymous codon substitutions can alleviate dependence on GroEL for folding.

10. Dysregulation of hepatic one-carbon metabolism in classical homocystinuria: Implications of redox-sensitive DHFR repression and tetrahydrofolate depletion for pathogenesis and treatment.

11. Drug resistance markers in Plasmodium vivax isolates from a Kanchanaburi province, Thailand between January to May 2023.

12. Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression.

13. Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study.

14. Characterization of drug resistance genes in Indian Plasmodium falciparum and Plasmodium vivax field isolates.

15. TaqMan-quantitative PCR assays applied in Neospora caninum knock-outs generated through CRISPR-Cas9 allow to determine the copy numbers of integrated dihydrofolate reductase-thymidylate synthase drug selectable markers .

16. Prevalence and genetic diversity of simian malaria in wild macaque populations across Thailand: Implications for human health.

17. Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion.

18. Cymoxanil disrupts RNA synthesis through inhibiting the activity of dihydrofolate reductase.

19. Sub-microscopic Plasmodium falciparum infections and multiple drug resistant single nucleotide polymorphic alleles in pregnant women from southwestern Nigeria.

20. Sanger sequencing and deconvolution of polyclonal infections: a quantitative approach to monitor drug-resistant Plasmodium falciparum.

21. Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance.

22. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting.

23. Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate.

24. Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021.

25. Systematic Review and Geospatial Modeling of Molecular Markers of Resistance to Artemisinins and Sulfadoxine-Pyrimethamine in Plasmodium falciparum in India.

26. Accelerated generation of gene-engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9.

27. The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance.

28. Repurposing FDA-approved drugs to target malaria through inhibition of dihydrofolate reductase in the folate biosynthesis pathway: A prospective approach.

29. Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR.

30. Identification of terpenoids as dihydropteroate synthase and dihydrofolate reductase inhibitors through structure-based virtual screening and molecular dynamic simulations.

31. Ultralight Ultrafast Enzymes.

32. Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus .

33. Molecular detection of antimalarial resistance in Plasmodium vivax isolates from a tertiary care setting in Puducherry.

34. A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations.

35. Geographical emergence of sulfadoxine-pyrimethamine drug resistance-associated P. falciparum and P. malariae alleles in co-existing Anopheles mosquito and asymptomatic human populations across Cameroon.

36. A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy.

37. Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand.

38. A rugged yet easily navigable fitness landscape.

39. Regulation of eDHFR-tagged proteins with trimethoprim PROTACs.

40. Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance.

41. Functional analysis of Rickettsia monacensis strain humboldt folA dihydrofolate reductase gene via complementation assay.

42. Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex.

43. Polymorphism analysis of drug resistance markers in Plasmodium falciparum isolates from Benin.

44. A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.

45. Plasmodium falciparum drug resistance-associated mutations in isolates from children living in endemic areas of Burkina Faso.

46. Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection.

47. Empowering drug off-target discovery with metabolic and structural analysis.

48. Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis.

49. Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019.

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