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221 results on '"Tessitore L"'

1. Cholesterol Metabolism and Proliferative Processes

Author

Dessì, S., Batetta, B., Pulisci, D., Accogli, P., Anchisi, C., Tessitore, L., Costelli, P., Baccino, F. M., Broccia, G., Pani, P., Columbano, Amedeo, editor, Feo, Francesco, editor, Pascale, Rosa, editor, and Pani, Paolo, editor

Published
1991
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5. Associated changes of lipid peroxidation and transforming growth factor β1 levels in human colon cancer during tumour progression. (Cancer)

Author

Biasi, F., Tessitore, L., Zanetti, D., Cutrin, J.C., Zingaro, B., Chiarpotto, E., Zarkovic, N., Serviddio, G., and Poli, G.

Subjects
Colorectal cancer -- Development and progression, Transforming growth factors -- Physiological aspects, Health, Physiological aspects, Development and progression
Abstract

Background: During neoplastic progression, alterations in transforming growth factor β1 (TGF-β1) dependent control of cell growth may be an important mechanism of selective proliferation of transformed cellular clones. Defective regulation [...]

Published
2002

6. Posters

Author

Cerny, V., Zivny, P., Dostal, P., Parizkova, R., Zabka, L., Hodgson, R. E., Bosenberg, A. T., Hadley, G. P., Spapen, H., Diltoer, M., Suys, E., Borremans, M., Ramet, J., Huyghens, L., Afessa, B., Murphy, R., Hogans, L., Meyers, B., Mentec, H., Gruchet, P., Squara, P., De Jonghe, B., Peillon, I., Sollet, J. P., Bleichner, G., Zivkovic, Z., Mihailovic, S., Jakovljevic, M., Ryan, D. W., Weldon, O. G. W., Gower, S. N., Whiteley, S. M., Bodenham, A., De Robertis, E., Liu, J. M., Svantesson, C., Oahm, P. L., Thöme, J., Blomquist, S., Jonson, B., Pelagatti, C., Barattini, M., Poli, C., Ricupero, L., Olmastroni, M., Pieraccioni, P., Padelletti, M. B., Romagnoli, P., Masi, A., Rossi, G. F., Kurz-Müller, K., Tryba, M., Pelosi, P., Chiumello, D., Croci, M., Gattinoni, L., Kofings, G., Kyriakidis, M., Betrosian, A., Georgiou, L., Toufouzas, P., Lim, C. M., Choi, J. E., Kon, Y., Lee, S. D., Kim, W. S., Park, P. H., Kim, D. S., Kim, W. D., Koh, Y., Jung, B. H., Kim, W. S., Mazzi, S., Petrucci, N., Agostini, F., Vischi, F., Mitic-Milikic, M., Vukcevic, M., Obradovic, Lj. Nagomi, Sekulic, S., Peláez, J., Asensio, M. J., Jiménez, M., Sisón, M., Yus, S., Cerdeño, V., Nishizuka, K., Tashiro, K., Matsumoto, Y., Kobayashi, T., Suzuki, Y., De Blasio, E., De Sio, A., Golia, D., Papa, A., Giurbino, M., Paulone, G., Evangelista, V., Imhoff, M., Greive, H., Lehner, J. H., Löhlein, D., Kelly, K. P., Busch, T., Loge, K., Gerlach, H., Falke, K. J., Rossaint, R., Herreo, S., Suarez, T., Mosácula, J., Lacort, M., Lapuerta, J. A., Guerra, J., Benini, A., Borelli, M., Lampati, L., Acciaro, M., Pesenti, A., Verweij, M., Marcolin, R., Bombino, M., Patroniti, N., Sordi, A., Tsareva, M., Petkoy, I., Kishen, R., Bowles, B. J. M., Thomas, A. N., Geraghty, I. F., Goodall, J., Grasso, S., Giuliani, R., Puntillo, F., Mascia, L., Fiore, T., Brienza, N., Ranieri, V. M., Pavlou, E., Zevla, E., Stavropoulou, M., Papazacharias, Ch., Loannidou, E., González F. X., Rull R., López-Boado M. A., Fábregas N., Alcón A., Moreno L. A., Zavala E., Hering, Ch., Ferrer, M., Masclans, J. R., Castellá, M., Anglés, R., Rodriguez-Roisin, R., Roca, J., Milic-Emili, J., Ferrer M., Polese G., Masclans J. R., Planas M., Milic-Emili J., Roca J., Rossi A., Rodriguez-Roisin R., Masclans, J. R., Planas, M., Bermejo, B., Valls, M., Picó, M., Porta, I., de Latorre, F. J., Rodríguez-Roisin, R., Anglès, R., Ferrer, R., Peracaula, R., Bellamy, M. C., Smith, S. N., Dahm, P. L., Thörne, J., Rossetti, H., Amaral, J. L. G., Amarante, G. A. J., Juliano, Y., Novo, N. F., Resta, O., Guido, P., Picca, V., Foschino, M. P., Lecce, G. A., Affuso, F., Resta, O., Foschino, M. P., Scarpelli, F., Sergi, M., Rizzi, M., Kirby, F., Healy, V., Mannion, D., Sweeney, E., Gil, A., SamPedro, J. M., Hernández, J., Carrizosa, J., Herrero, F., Martin, A., Sandaz, D., Rialp, G., López-Velarde, G., Subirana, M., Bak, E., Santos, J. A., Ormaechea, E., Net, A., Benito, S., Mancebo, J., Vallverdú, I., Rialp, G., Subirana, M., Santos, J. A., Benito, S., Vallverdú, I., Stricker, H., Domenighetti, G., Waldispuehl, B., Feickert, H. J., Kayser, Ch., Sasse, M., Grüning, T., Pappert, D., Merker, G., Steinau, R., Wenz, M., Lange, M., Gerlach, H., Kaczmarczyk, G., De Deyne, C., Decruyenaere, J., Hoste, E., Colardyn, F., Bar-Lavie, Y., Borg, U., Kuramoto, J., Habashi, N., Reynolds, H. N., Walder, B., Bründler, M. A., Spiliopoulos, A., Zürcher, R., Nicod, L., Romand, J. A., Alyoshkin, A. V., Zarubina, T. V., Okhuysen, R. S., Bristow, F., Alpert, B. E., Frates, R. C., De Laat, M., Vermassen, F., Subirana, M., Betbesé, A. J., Pérez, M., Rialp, G., Santos, A., Subirana, M., Subirana, M., Betbesé, A., Subirana, M., Kanhai, J. K. K., Strijdhorst, H., Pompe, J. C., Bruining, H. A., Huygen, P. E. M., Teba, L., Singh, S. G., Dedhia, H. V., Vivaldi, G. Ferrari, Pedersini, G., Cingia, C., Ferrari, M., Marzollo, P., Kunert∼, M., Scheuble∼, L., Johanns’, M., Adnet, F., Benaissa M. L., Bekka R., Plaisance, P., Lapandry, C., Lapostolle, F., Baud, F., Solca, M., Ravagnan, I., Pedoto, A., Piquemal, R., Dequin, P. F., Hazouard E., Legras, A., Perrotin, D., Ginies, G., Calzia, E., Lindner, K. H., Radermacher, P., Steltzer, H., Krafft, P., Krenn, C. G., Fridrich, P., Hammerle, A. F., Gill, R. S., Pappachan, J. V., Young, M. A., Taylor, B. L., Smith, G. B., Lachana, Alexandra, Dimitroula, V., Stergiou, P., Nakos, G., Haberthür, C., Fabry, B., Zappe, D., Volta, C., Gottfried, S., Goldberg, P., Beuret, P., Carton, M. J., De Pasquale, V., Harlay, M. L., Cannamela, A., Ducreux, J. C., Tempelhoff, G., Eremenko, A. A., Chaus, N. I., Levicov, D. I., Bozhieva, L. V., Revuelta, P., Frutos, F., Núñez, C., Garrido, P., Lorenzo, J. M., Tamayo, L., Freire E., Silva A., Caminha J., Carneiro A., Reis E., Rocha N., Lopes M., Paes Cardoso A., Rua F., Young, J. D., Allman, K. G., Wallin, C. -J., Rundgren, M., Eriksson, S., Hjelmqvist, H., Leksell, L. G., Nicolayenko, E. M., Grischenko, A. V., Fomicheva, A. V., Soltan, S. A., Stepanov, N. A., Anaslasaki, M., Agouridakls, P., Katsanoulas, K., Moloudl, E., Chaniotakls, E., Askitopoulou, E., Agouridakis, P., Katsanoulas, K., Lampakis, S., Chaniotaki, F., Groutsou, H., Gregoretti, C., Navaleai, P., Foti, G., Turello, M., Muato, P., Šakić, K., Pećina, M., Šakić, Š, Del Nogal, F., Jiménez, M. J., García, M. A., Suárez, J., Temprano, S., Díaz, R., López, J., Zupancich, E., Turani, F., Tessitore, L., Mastrofrancesco, P., Celeste, G., Curatola, D., Sabato, A. F., Kellv, K. P., Gerlach, H., Ludwigs, U., Sánchez, A., Jiménez, J. M., Guerrero, A., Martínez, S., Chirosa, M., Marín, M., Young, P. J., Rollinson, M., Downward, G., Henderson, S., Mas, A., Martínez, M., Díaz, E., Joseph, D., Baigorri, F., Blanch, LI., Blanch, L., Perez, M., Martinez, M., Betbese, A. J., Subirana, M., Jam, R., Lucangelo, U., Hernández, E., Jam, M. R., Ortiz, D., Ayala, S., Noray, M., Blanch, L. I., Royo, C., Zappe, D., Haberthür, C., Díaz, O., Saldías, F., Andresen, M., Arriagada, D., Dougnac, A., Laterre, P. F., Raynaert, M., Jorquera, R., Florence, E., Espeel, B., Roeseler, J., Capodilupo, G., Reynaert, M. S., Gabrielli, C., Michel, F., Nibbe, L., Kuhlen, R., Hausmann, S., Max, M., Sprenger, M., Haberthür, Ch., Falke, K., Olivei, M., Galbusera, C., Veronesi, R., Palo, A., Comelli, A., Zanierato, M., Iotti, G., Brunner, J. X., Braschi A., Galbusera C., Olivei M., Zanierato M., Rinaldi M., Palo A., Veronesi R., Viganó M., Braschi A., Stopar, T., Danovitch, K., Gursahaney, A., Gottfried, S. B., Reper, P., Danckaert, R., Wybaux, O., Jagodzinski, R., Lampaert, P., Jeunen, R., Vanderkelen, A., Pinder, M., Lipman, J., Hon, H., Low, J. H. S., and Wells, M.

Published
1996
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8. Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer

Author

Dessi, Sandra, Batetta, B., Pulisci, D., Spano, O., Anchisi, C., Tessitore, L., Costelli, P., Baccino, F.M., Aroasio, E., and Pani, P.

Subjects
Gastrointestinal cancer -- Causes of, Blood lipoproteins -- Physiological aspects, Tumors -- Growth, Cholesterol, HDL -- Health aspects, Health
Abstract

Background. The authors have previously demonstrated in different experimental models that sustained processes of cellular growth are characterized by alterations of cholesterol metabolism not only in the proliferating tissues but also in the plasma compartment. Methods. To evaluate whether alterations of cholesterol metabolism similar to those observed in experimental models are also associated with human cancer, in the present study cholesterol distribution in tumor tissues and lipid composition in the plasma compartment were determined in patients with different types of gastrointestinal cancer. Results. The results showed that tumor tissues contain increased amounts of cholesterol when compared with the corresponding normal tissues. Intracellular alterations of cholesterol were accompanied by specific changes of cholesterol in the plasma compartment: high-density lipoprotein (HDL) cholesterol was markedly reduced in the serum of patients with gastrointestinal cancer and the lipoprotein profiles showed a decrease in HDL, fraction, the main HDL subfraction in human serum. The decrease of HDL cholesterol was negatively associated with the clinical stage of the disease. No changes in either total or low-density lipoprotein cholesterol levels were observed. Conclusions. A major function attributed to HDL is to maintain normal cell cholesterol homeostasis by removing excess of cholesterol from intracellular pools. Because the use and storage of cholesterol are increased within the tumor tissues during growth, it is possible to hypothesize that low HDL levels observed in patients with gastrointestinal cancer are associated with the increased cholesterol metabolism in proliferating tissues. Cancer 1994; 73:253-8.

Published
1994

10. Gene therapy in cancer: the missing point

Author

Farber E, Geliebter J, Darja Kanduc, Lucchese A, Mazzanti R, Mittelman A, Polimeno L, Ponzetto A, Santacroce R, Simone S, Aa, Sinha, Sinigaglia E, Tessitore L, Rk, Tiwari, Kanduc, D, Geliebter, J, Lucchese, Alberta, Mazzanti, R, Mittelman, A, Polimeno, L, Pozzetto, A, Santacroce, R, Simone, S, Sinigaglia, E, Sinha, Aa, Tessitore, L, Tiwari, Rk, and Farber, E.

Subjects
Chromosome Aberrations, Neoplasms, Mutation, Humans, Genetic Therapy
Abstract

Over the last century cancer research has produced data leading to a composite picture where gene mutations and epigenetic phenomena strictly relate and overlap. This complexity has repercussions on the anti-cancer therapeutical strategies. The therapeutic pathway paved by the kochian one-cause/one disease principle fails in front of a multigenic multiphenomena disease like cancer. We still do not know what target(s) to hit/modify in order to prevent/stop the carcinogenic progression. On the light of cancer statistics 2005, we discuss the need of exactly defining the cancer targets in order to exploit the high potential of gene therapy.

Published
2005

11. Associated changes of lipid peroxidation and transforming growth factor b1 levels in human colon cancer during tumour progression

Author

Biasi, F., Tessitore, L., Zanetti, D., Cutrin, J. C., Zingaro, B., Chiarpotto, E., Žarković, Neven, Serviddio, G., and Poli, G.

Subjects
Tgf-beta, Ii receptors, Microsatellite instability, Heterooligomeric complexes, Colorectal-cancer, Gene-expression, Cells, Growth-factor-beta-1, Adenocarcinoma, Proteins
Abstract

Background: During neoplastic progression, alterations in transforming growth factor b1 (TGF-b1) dependent control of cell growth may be an important mechanism of selective proliferation of transformed cellular clones. Defective regulation of TGF-b1 receptors has been reported to occur in a number of human malignant tumours while little is known of the actual levels of this growth inhibitory cytokine in cancer. On the basis of the demonstrated ability of major lipid peroxidation products such as 4-hydroxynonenal to modulate TGF-b1 expression and synthesis, we speculated that decreased lipid oxidation, as frequently observed in neoplastic tissues, would contribute to the selective promotion of tumour growth through decreased expression of the cytokine within the tumour mass. Aims: To seek a possible association between steady state levels of major aldehydic end products of lipid peroxidation and TGF-b1 content in human colon cancer at different stages of growth. Patients and methods: Tissue biopsies from 15 adult patients with colon adenocarcinoma of different TNM and G stagings were compared with regard to lipid peroxidation aldehydes and net TGF-b1 levels. For a more comprehensive analysis, cytokine type I and II receptors were measured in tumour biopsies. In one set of experiments, to support the conclusions, the apoptotic effect of TGF-b1 was evaluated in a human colon cancer cell line, CaCo-2, retaining receptor changes consistent with those observed in cancer patients. Results: With the exception of two extremely advanced cases (T4/G3) in which tissue levels of lipid peroxidation were within the normal range, 4-hydroxynonenal was significantly decreased in all other cancer specimens. Consistent with lipid peroxidation levels, TGF-b1 protein was markedly decreased or even negligible compared with the corresponding normal tissue surrounding the tumour in all tested biopsies except for the two T4/G3 colon cancers in which cytokine content was again within the normal range. As regards TGF-b1 receptors, both in tumour sections and CaCo-2 cells, downregulation was greater for TGF-b1 receptor I than for receptor II. Of note, in CaCo-2 cells, incubation with appropriate doses of TGF-b1 led to marked nuclear fragmentation and apoptosis. Conclusions: Evasion of human colon cancer cells from TGF-b1 mediated growth inhibition appears to be due not only to downregulation of TGF-b1 receptors, which is inconsistent and unrelated to cancer development, but also to the constant low concentration of this cytokine in the tumour mass. The associated levels of lipid peroxidation aldehydes, much lower than in control tissue, probably represent a lower stimulus for TGF-b1 production in the neoplastic area and thus a favourable condition for neoplastic progression.

Published
2002

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