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2. Safety of COVID-19 Vaccines Among the Paediatric Population: Analysis of the European Surveillance Systems and Pivotal Clinical Trials

Author

Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P. W., Bucsa C., Osman A., Liddiard M., Maques F. B., Petrelli G., Sonderlichova S., Thurin N. H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L. A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P. M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M. P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A. M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M. S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M. A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., Mastropasqua D., Ahmadizar F., Luxi N., Raethke M., Schmikli S., Riefolo F., Saraswati P.W., Bucsa C., Osman A., Liddiard M., Maques F.B., Petrelli G., Sonderlichova S., Thurin N.H., Villalobos F., Trifiro G., Sturkenboom M., Moretti U., Bellitto C., Ciccimarra F., Gonella L.A., Arzenton E., Chiamulera C., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Cutroneo P.M., Minore C., Costantino C., Vitale F., D'Alessandro G., Morreale I., Marsala L., Farinella D., Bavetta S., Fantini M.P., Reno C., Raschi E., Poluzzi E., Sapigni E., Potenza A.M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M.S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Gavioli B., Palazzi S., Tuccori M., Vannacci A., Bonaiuti R., Ravaldi C., Lombardi N., Crescioli G., Gori F., Tessari R., Zandona E., Zanoni G., Senna G., Crivellaro M.A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Capuano A., Rafaniello C., Ferrajolo C., Pagliaro C., Mercaldo M., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., de Sarro C., Verduci C., Papadopoli R., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., and Mastropasqua D.

Subjects
COVID-19 Vaccines, safety, Surveillance Systems, Pivotal Clinical Trials
Abstract

Background and Objectives: The European Medicine Agency extended the use of Comirnaty, Spikevax, and Nuvaxovid in paediatrics; thus, these vaccines require additional real-world safety evidence. Herein, we aimed to monitor the safety of COVID-19 vaccines through Covid-19 Vaccine Monitor (CVM) and EudraVigilance surveillance systems and the published pivotal clinical trials. Methods: In a prospective cohort of vaccinees aged between 5 and 17 years, we measured the frequency of commonly reported (local/systemic solicited) and serious adverse drug events (ADRs) following the first and second doses of COVID-19 vaccines in Europe using data from the CVM cohort until April 2022. The results of previous pivotal clinical trials and data in the EudraVigilance were also analysed. Results: The CVM study enrolled 658 first-dose vaccinees (children aged 5–11 years; n = 250 and adolescents aged 12–17 years; n = 408). Local/systemic solicited ADRs were common, whereas serious ADRs were uncommon. Among Comirnaty first and second dose recipients, 28.8% and 17.1% of children and 54.2% and 52.2% of adolescents experienced at least one ADR, respectively; injection-site pain (29.2% and 20.7%), fatigue (16.1% and 12.8%), and headache (22.1% and 19.3%) were the most frequent local and systemic ADRs. Results were consistent but slightly lower than in pivotal clinical trials. Reporting rates in Eudravigilance were lower by a factor of 1000. Conclusions: The CVM study showed high frequencies of local solicited reactions after vaccination but lower rates than in pivotal clinical trials. Injection-site pain, fatigue, and headache were the most commonly reported ADRs for clinical trials, but higher than spontaneously reported data.

Published
2023

5. High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial

Author

Buonfrate D, Chesini F, Martini D, Roncaglioni MC, Ojeda Fernandez ML, Alvisi MF, De Simone I, Rulli E, Nobili A, Casalini G, Antinori S, Gobbi M, Campoli C, Deiana M, Pomari E, Lunardi G, Tessari R, and Bisoffi Z

Subjects
COVID-19, Ivermectin, Randomised controlled trial, SARS-CoV-2
Abstract

High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in vitro. The aim of this study was to assess the safety and efficacy of high-dose ivermectin in reducing viral load in individuals with early SARS-CoV-2 infection. This was a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial. Participants were adults recently diagnosed with asymptomatic/oligosymptomatic SARS-CoV-2 infection. Exclusion criteria were: pregnant or lactating women; CNS disease; dialysis; severe medical condition with prognosis 10viral load reduction was 2.9 (1.6) in arm C, 2.5 (2.2) in arm B and 2.0 (2.1) in arm A, with no significant differences (P = 0.099 and 0.122 for C vs. A and B vs. A, respectively). High-dose ivermectin was safe but did not show efficacy to reduce viral load. For anonymization purpose, the dates of recruitment have been shifted of an unspecifiednumber of days. However, timeframe between follow up visits remains fixed.

Published
2022

6. Associations between ultrasound hepatic measurements, body measures, and milk production traits in Holstein cows

Author

Piazza, M., Giannuzzi, D., Tessari, R., Fiore, E., Gianesella, M., Pegolo, S., Schiavon, S., Trevisi, Erminio, Piccioli Cappelli, Fiorenzo, Cecchinato, A., Gallo, L., Trevisi E. (ORCID:0000-0003-1644-1911), Piccioli-Cappelli F. (ORCID:0000-0003-1277-7821), Piazza, M., Giannuzzi, D., Tessari, R., Fiore, E., Gianesella, M., Pegolo, S., Schiavon, S., Trevisi, Erminio, Piccioli Cappelli, Fiorenzo, Cecchinato, A., Gallo, L., Trevisi E. (ORCID:0000-0003-1644-1911), and Piccioli-Cappelli F. (ORCID:0000-0003-1277-7821)

Abstract

Ultrasound (US) imaging has been proposed as a noninvasive tool for monitoring liver dysfunction in dairy cows. This study, carried out on 306 clinically healthy Holstein cows in the first 120 d of lactation kept in 2 herds in northern Italy, aimed at investigating the association between US imaging-derived traits, namely predicted liver triacylglycerol content (pTAG, mg/g), liver depth (LD, mm), portal vein depth (PVD, mm) and area (PVA, mm2), and body size measurements, body condition score (BCS), and milk productivity indicators. Transcutaneous US examination, milk sampling, body size measurements (withers height and heart girth), and BCS were collected once from all cows in 10 sampling batches. The body weights (BW) of a subsample of 73 cows were recorded and used together with an existing data set of BW and measures of Holstein Friesian cows (n = 399) to develop a regression equation to predict BW, which was then used to compute productivity indicators by scaling the milk production traits to predicted BW. Body size measures, BCS, milk traits, and productivity indicators were classified (low, medium, and high) in 0.75 units of standard deviation of the residuals generated from a linear model that included the effects of parity, days in milk, and sampling batch. Liver pTAG, PVA, PVD, and LD were analyzed with a sequence of linear mixed models that included the fixed effects of days in milk and parity and the random effect of sampling batch as common terms, whereas the classes of body and milk traits and the productivity indicators were included one by one. The US-related traits were found to be associated with body size measurements and BCS. Specifically, pTAG was inversely related to BCS, whereas PVD and LD increased with increasing heart girth, BCS, and predicted BW. Generally, no relevant associations were observed between the US parameters and milk production traits, including when expressed in terms of productivity. In conclusion, this study suggests that U

Published
2022

7. Quarter-level analyses of the associations among subclinical intramammary infection and milk quality, udder health, and cheesemaking traits in Holstein cows

Author

Pegolo, S., Tessari, R., Bisutti, V., Vanzin, A., Giannuzzi, D., Gianesella, M., Lisuzzo, A., Fiore, E., Barberio, A., Schiavon, E., Trevisi, E., Piccioli Cappelli, F., Gallo, L., Ruegg, P., Negrini, R., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), Piccioli Cappelli F. (ORCID:0000-0003-1277-7821), Negrini R. (ORCID:0000-0002-8735-0286), Pegolo, S., Tessari, R., Bisutti, V., Vanzin, A., Giannuzzi, D., Gianesella, M., Lisuzzo, A., Fiore, E., Barberio, A., Schiavon, E., Trevisi, E., Piccioli Cappelli, F., Gallo, L., Ruegg, P., Negrini, R., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), Piccioli Cappelli F. (ORCID:0000-0003-1277-7821), and Negrini R. (ORCID:0000-0002-8735-0286)

Abstract

In this study, we investigated associations among subclinical intra-mammary infection (IMI) and quarter-level milk composition, udder health indicators, and cheesemaking traits. The dataset included records from 450 Holstein cows belonging to three dairy herds. After an initial screening (T0) to identify animals infected by Streptococcus agalactiae, Streptococcus uberis, Staphylococcus aureus, and Prototheca spp., 613 quarter milk samples for 2 different sampling times (T1 and T2, 1 mo after T1) were used for analysis. Milk traits were analyzed using a hierarchical linear mixed model including the effects of days in milk, parity and herd, and bacteriological and inflammatory category [culture negative with somatic cell count (SCC) <200,000 cells/mL; culture negative with SCC ≥200,000 cells/mL; or culture positive]. All udder health indicators were associated with increased SCC and IMI at both sampling times. The largest effects were detected at T2 for milk lactose (−7% and −5%) and milk conductivity (+9% and +8%). In contrast, the increase in differential SCC (DSCC) in samples with elevated SCC was larger at T1 (+17%). Culture-negative samples with SCC ≥200,000 cells/mL had the highest SCC and greatest numbers of polymorphonuclear-neutrophils-lymphocytes and macrophages at both T1 and T2. Regarding milk cheesemaking ability, samples with elevated SCC showed the worst pattern of curd firmness at T1 and T2. At T2, increased SCC and IMI induced large decreases in recoveries of nutrients into the curd, in particular recovered protein (−14% and −16%) and recovered fat (−12% and −14%). Different behaviors were observed between Strep. agalactiae and Prototheca spp., especially at T2. In particular, samples that were positive for Strep. agalactiae had higher proportions of DSCC (+19%) compared with negative samples with low SCC, whereas samples that were positive for Prototheca spp. had lower DSCC (−11%). Intramammary infection with Prototheca spp. increased milk pH comp

Published
2022

8. How to improve TB outpatient service in a TB low-endemic country during SARS-CoV-2 pandemic

Author

Riccardi, N., Rodari, P., Duranti, S., Villa, S., Assante, L. R., Castellotti, P., Ferrarese, M., Martini, M., Zuppini, T., Tessari, R., Calza, C., Codecasa, L., Besozzi, G., and Angheben, A.

Subjects
Ethics, TB-care, SARS-CoV-2, Antitubercular Agents, COVID-19, Italy, Medical ethics, Outpatient care, Tuberculosis, Ambulatory Care, Ethics, Medical, Humans, Outpatient Clinics, Hospital, Pandemics, Telemedicine, Hospital, Medical, Outpatient Clinics, Research Article
Abstract

Summary Despite notable progresses in the recent decades, tuberculosis (TB) continues to remain a public health concern even in Europe. TB prevention and care should be people-centred, improving ambulatory models across countries, in order to expand access to diagnosis and treatment for both TB infection and disease. Even more, during emergencies such as the current pandemic, when seeking of TB care has been replaced by the fear of coronavirus disease 2019 (COVID-19), TB patient’s care is fundamental. In this short communication, we document how was possible to implement a TB outpatient service meanwhile a local outbreak of SARS-CoV-2 transmission was ongoing.

Published
2021

9. Quarter-level analyses of the associations among subclinical intramammary infection and milk quality, udder health, and cheesemaking traits in Holstein cows

Author

Pegolo, S., primary, Tessari, R., additional, Bisutti, V., additional, Vanzin, A., additional, Giannuzzi, D., additional, Gianesella, M., additional, Lisuzzo, A., additional, Fiore, E., additional, Barberio, A., additional, Schiavon, E., additional, Trevisi, E., additional, Piccioli Cappelli, F., additional, Gallo, L., additional, Ruegg, P., additional, Negrini, R., additional, and Cecchinato, A., additional

Published
2022
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11. COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety

Author

Luxi N., Giovanazzi A., Capuano A., Crisafulli S., Cutroneo P. M., Fantini M. P., Ferrajolo C., Moretti U., Poluzzi E., Raschi E., Ravaldi C., Reno C., Tuccori M., Vannacci A., Zanoni G., Trifiro G., Petrelli G., Girotti S., Arzenton E., Magro L., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Spina E., Minore C., Costantino C., Conforto A., Vitale F., Morreale I., Marsala L., Farinella D., Bavetta S., Sapigni E., Potenza A. M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M. S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Pappalardo F., Bonaiuti R., Lombardi N., Crescioli G., Tessari R., Zandona E., Marchiori F., Chiamulera C., Senna G., Crivellaro M. A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Rafaniello C., Pagliaro C., Mercaldo M., Fucile A., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Leopardi E., Fava G., Giuffrida S., Amato V., Gambera M., Montresor V., Luxi N., Giovanazzi A., Capuano A., Crisafulli S., Cutroneo P.M., Fantini M.P., Ferrajolo C., Moretti U., Poluzzi E., Raschi E., Ravaldi C., Reno C., Tuccori M., Vannacci A., Zanoni G., Trifiro G., Luxi, N., Giovanazzi, A., Capuano, A., Crisafulli, S., Cutroneo, P. M., Fantini, M. P., Ferrajolo, C., Moretti, U., Poluzzi, E., Raschi, E., Ravaldi, C., Reno, C., Tuccori, M., Vannacci, A., Zanoni, G., Trifiro, G., Petrelli G., Girotti S., Arzenton E., Magro L., Lora R., Bellantuono D., Sabaini A., Firenze A., Zodda D., Guidotti F., Zappone M., Alagna B., Spina E., Minore C., Costantino C., Conforto A., Vitale F., Morreale I., Marsala L., Farinella D., Bavetta S., Sapigni E., Potenza A.M., Podetti D., Nikitina V., Ricciardelli R., Mogheiseh N., Croce S., Paltrinieri B., Castellani S., Sangiorgi E., Selleri M., Lucchesi S., Catucci G., Savini D., Sacripanti C., Faccioli M., Romio M.S., Rossi L., Radici S., Negri G., Fares L., Ajolfi C., Fadda A., Chiarello A., Pieraccini F., Pappalardo F., Bonaiuti R., Lombardi N., Crescioli G., Tessari R., Zandona E., Marchiori F., Chiamulera C., Senna G., Crivellaro M.A., Cancian M., Venturini F., Ferri M., Leonardi L., Orzetti S., Caccin E., Baldo P., Rafaniello C., Pagliaro C., Mercaldo M., Fucile A., di Giorgio A., Tari M., Manna S., Farina G., Di Mauro C., De Carlo I., Senesi I., Pileggi C., Palleria C., Gallelli L., De Sarro G., Trabace L., Morgese M., Schiavone S., Tucci P., Bove M., Lapi F., Cricelli C., Racagni G., Tonolo S., Leopardi E., Fava G., Giuffrida S., Amato V., Gambera M., and Montresor V.

Subjects
Allergy, IMPACT, COVID-19 Vaccine, Breastfeeding, Review Article, Toxicology, Settore MED/42 - Igiene Generale E Applicata, CLINICAL CHARACTERISTICS, Pregnancy, Pharmacology (medical), Pregnancy Complications, Infectious, Child, OUTCOMES, education.field_of_study, CANCER, Vaccination, Europe, CORONAVIRUS DISEASE 2019, CLINICAL CHARACTERISTICS, CANCER, RECIPIENTS, SEVERITY, OUTCOMES, IMPACT, RATES, Breast Feeding, Child, Preschool, Practice Guidelines as Topic, Female, 2019-nCoV Vaccine mRNA-1273, Human, Adult, medicine.medical_specialty, COVID-19 Vaccines, Adolescent, BNT162 Vaccine, COVID-19, ChAdOx1 nCoV-19, Humans, Infant, SARS-CoV-2, Hypersensitivity, Immunocompromised Host, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, MEDLINE, CORONAVIRUS DISEASE 2019, medicine, RATES, education, Pharmacology, business.industry, medicine.disease, Vaccine efficacy, RECIPIENTS, SEVERITY, Family medicine, Pregnancy Complications, Infectiou, business
Abstract

To date, four vaccines have been authorised for emergency use and under conditional approval by the European Medicines Agency to prevent COVID-19: Comirnaty, COVID-19 Vaccine Janssen, Spikevax (previously COVID-19 Vaccine Moderna) and Vaxzevria (previously COVID-19 Vaccine AstraZeneca). Although the benefit–risk profile of these vaccines was proven to be largely favourable in the general population, evidence in special cohorts initially excluded from the pivotal trials, such as pregnant and breastfeeding women, children/adolescents, immunocompromised people and persons with a history of allergy or previous SARS-CoV-2 infection, is still limited. In this narrative review, we critically overview pre- and post-marketing evidence on the potential benefits and risks of marketed COVID-19 vaccines in the above-mentioned special cohorts. In addition, we summarise the recommendations of the scientific societies and regulatory agencies about COVID-19 primary prevention in the same vaccinee categories. Supplementary Information The online version contains supplementary material available at 10.1007/s40264-021-01131-6.

Published
2021

15. Associations between ultrasound measurements and hematochemical parameters for the assessment of liver metabolic status in Holstein–Friesian cows

Author

Giannuzzi, D., Tessari, R., Pegolo, S., Fiore, E., Gianesella, M., Trevisi, Erminio, Ajmone Marsan, Paolo, Premi, M., Piccioli Cappelli, Fiorenzo, Tagliapietra, F., Gallo, L., Schiavon, S., Bittante, G., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), Ajmone Marsan P. (ORCID:0000-0003-3165-4579), Piccioli Cappelli F. (ORCID:0000-0003-1277-7821), Giannuzzi, D., Tessari, R., Pegolo, S., Fiore, E., Gianesella, M., Trevisi, Erminio, Ajmone Marsan, Paolo, Premi, M., Piccioli Cappelli, Fiorenzo, Tagliapietra, F., Gallo, L., Schiavon, S., Bittante, G., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), Ajmone Marsan P. (ORCID:0000-0003-3165-4579), and Piccioli Cappelli F. (ORCID:0000-0003-1277-7821)

Abstract

Metabolic disorders, including hepatic lipidosis and ketosis, severely affect animal health status and welfare with a large economic burden in dairy herds. The gold standard for diagnosing hepatic lipidosis is the liver biopsy, which is impractical and invasive for the screening at farm level. Ultrasound (US) imaging is a promising technique for identifying liver dysfunction, but standardized specifications in physiological conditions are needed. Herein, we described the features of four US measurements, namely the liver predicted triacylglycerol (pTAG) content, liver depth (LD), and portal vein area (PVA) and depth (PVD) and we investigated their associations with a set of hematochemical (HC) indicators in 342 clinically healthy Holstein Friesian dairy cows. Liver pTAG content was negatively associated with hematocrit and positively with globulin, whereas PVA was negatively associated with thiol group levels, and LD positively with ceruloplasmin. We found significant interactions between some HC parameters and parity: in particular, creatinine, thiol groups and globulin for PVA, and aspartate aminotransferase, paraoxonase and ceruloplasmin for PVD. This study offers new insights on variations in liver function occurring after calving and pave the way for the potential use of minimally invasive techniques for prompt detection of metabolic disorders in dairy herds.

Published
2021

16. Associations between differential somatic cell count and milk yield, quality, and technological characteristics in Holstein cows

Author

Pegolo, S., Giannuzzi, D., Bisutti, V., Tessari, R., Gelain, M. E., Gallo, L., Schiavon, S., Tagliapietra, F., Trevisi, Erminio, Ajmone Marsan, Paolo, Bittante, G., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), Ajmone Marsan P. (ORCID:0000-0003-3165-4579), Pegolo, S., Giannuzzi, D., Bisutti, V., Tessari, R., Gelain, M. E., Gallo, L., Schiavon, S., Tagliapietra, F., Trevisi, Erminio, Ajmone Marsan, Paolo, Bittante, G., Cecchinato, A., Trevisi E. (ORCID:0000-0003-1644-1911), and Ajmone Marsan P. (ORCID:0000-0003-3165-4579)

Abstract

The aim of this study was to investigate the associations between differential somatic cell count (DSCC) and milk quality and udder health traits, and for the first time, between DSCC and milk coagulation properties and cheesemaking traits in a population of 1,264 Holstein cows reared in northern Italy. Differential somatic cell count represents the combined proportions of polymorphonuclear neutrophils plus lymphocytes (PMN-LYM) in the total somatic cell count (SCC), with macrophages (MAC) making up the remaining proportion. The milk traits investigated in this study were milk yield (MY), 8 traits related to milk composition and quality (fat, protein, casein, casein index, lactose, urea, pH, and milk conductivity), 9 milk coagulation traits [3 milk coagulation properties (MCP) and 6 curd firming (CF) traits], 7 cheesemaking traits, 3 cheese yield (CY) traits, and 4 milk nutrient recovery in the curd (REC) traits. A linear mixed model was fitted to explore the associations between SCS combined with DSCC and the aforementioned milk traits. An additional model was run, which included DSCC expressed as the PMN-LYM and MAC counts, obtained by multiplying the percentage of PMN-LYM and MAC by SCC in the milk for each cow in the data set. The unfavorable association between SCS and milk quality and technological traits was confirmed. Increased DSCC was instead associated with a linear increase in MY, casein index, and lactose proportion and a linear decrease in milk fat and milk conductivity. Accordingly, DSCC was favorably associated with all MCP and CF traits (with the exception of the time needed to achieve maximum, CF), particularly with rennet coagulation time, and it always displayed linear relationships. Differential somatic cell count was also positively associated with the recovery of milk nutrients in the curd (protein, fat, and energy), which increased linearly with increasing DSCC. The PMN-LYM count was rarely associated with milk traits, even though the pattern

Published
2021

22. PSS9 - DRUGS UTILISATION IN THE ITALIAN SETTING: THE CASE OF WAMD, DME AND RVO

Author

Ferrario, L., primary, Foglia, E., additional, Bandello, F., additional, Castelletti, C., additional, Franzin, M., additional, Gatti, F., additional, Machiavelli, A., additional, Mainardi, G., additional, Marziani, E., additional, Saccardi, A., additional, Tessari, R., additional, Trabucchi, G., additional, Varalli, L., additional, Zuppini, T., additional, and Croce, D., additional

Published
2018
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25. HTA & MCDA In The Treatment of Macular Edema

Author

Ferrario, L, primary, Foglia, E, additional, Bandello, F, additional, Ferri, C, additional, Figini, I, additional, Franzin, M, additional, Gambaro, G, additional, Introini, U, additional, Staurenghi, G, additional, Tadini, P, additional, Zuppini, T, additional, Tessari, R, additional, Scarpa, G, additional, Urban, F, additional, Beltramini, S, additional, Tobaldi, RF, additional, Nicolò, M, additional, Ancona, C, additional, Moriconi, S, additional, Nuti, E, additional, Fusco, F, additional, and Croce, D, additional

Published
2017
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29. [Air pollution and mortality in ten Italian cities. Results of the EpiAir Project]

Author

Stafoggia M, Faustini A, Rognoni M, Tessari R, Cadum E, Pacelli B, Pandolfi P, Miglio R, Mallone S, Ma, Vigotti, Serinelli M, Gabriele Accetta, Mp, Dessì, Cernigliaro A, Galassi C, Berti G, Forastiere F, Gruppo collaborativo EpiAir, Stafoggia M, Faustini A, Rognoni M, Tessari R, Cadum E, Pacelli B, Pandolfi P, Miglio R, Mallone S, Vigotti MA, Serinelli M, Accetta G, Dessì MP, Cernigliaro A, Galassi C, Berti G, Forastiere F, and Gruppo collaborativo EpiAir

Subjects
Adult, Aged, 80 and over, Male, Epidemiology, Urban Health, Middle Aged, SHORT TERM EFFECTS, Italy, TIME SERIES, Air Pollution, Population Surveillance, Humans, Female, Mortality, Aged
Abstract

OBJECTIVE: the relationship between air pollution and mortality has been well established in national and international scientific literature. This study reports the results of the EpiAir Project relative to the effect of air pollution on mortality in 10 Italian cities during 2001-2005. The association between particulate matter (PM10) and gases (nitrogen dioxide, NO2, and ozone, O3), and all natural mortality, as well as cardiac, cerebrovascular and respiratory mortality, is presented. Specific issues have been investigated, such as the latency of the air pollution-mortality effects and the identification of individual demographic characteristics and clinical conditions that result in greater susceptibility to the effects of particulate matter. METHODS: the study population consisted of 276,205 subjects aged 35+ years old, resident in one of the 10 Italian cities studied, which died in the city between 2001-2005. For each subject, information was collected on cause of death, location of death, demographical variables and hospital discharge diagnoses in the previous 2-year period. The statistical analysis was adjusted for the relevant temporal and meteorological factors using the case-crossover approach. The results for ozone are limited to the warm semester (April through September). An analysis of the association between air pollution and mortality was conducted for each city, and the city-specific estimates were meta-analyzed on a second level to obtain a pooled result, and reported inter-city heterogeneity. RESULTS: a short-term effect of PM10 on mortality has been detected for all the groups of causes considered, with latencies ranging from lag 0 for cerebrovascular mortality to lag 0-3 for respiratory mortality. The association between NO2 and mortality displays strong and similar effects for all death causes, with prolonged effects (lag 0-5) for all groups of causes. The results for O3 are similar to those found for NO2, with prolonged latency (lag 0-5) for all causes of death with the exception of cerebrovascular mortality, for which a delayed effect (lag 3-5) was identified. Individual susceptibility factors of the PM10-natural mortality association include age, as elderly subjects are especially vulnerable to the effects of particles. CONCLUSIONS: the main results of the study suggest that the air pollution originated by vehicular traffic is the most relevant environmental problem in Italian cities from a public health viewpoint.

Published
2010

33. I dati sanitari nel Progetto EpiAir

Author

Galassi, C, Faustini, A, Colais, P, Stafoggia, M, Berti, G, Biggeri, A, Bisanti, L, Cernigliaro, A, Chiusolo, M, Mallone, S, Pandolfi, P, Serinelli, M, Tessari, R, Vigotti, MARIA ANGELA, and Forastiere, F.

Subjects
hospital discharge, health databases, mortality
Published
2009

34. Inquinamento atmosferico e salute: sorveglianza epidemiologica e interventi di prevenzione ovvero come orientarsi nella lettura e interpretazione di studi ambientali, tossicologici ed epidemiologici

Author

Baldacci, S, Maio, S, Viegi, G, Gruppo Collaborativo EpiAir: Forastiere, F, Bisanti, L, Randi, G, Rognoni, M, Simonato, L, Tessari, R, Berti, G, Cadum, E, Chiusolo, M, Grosa, Mm, Ivaldi, C, Pelosini, R, Poncino, S, Galassi, C, Pacelli, B, Pandolfi, P, Scarnato, C, Miglio, R, Caranci, N, Pace, G, Zanini, G, Grechi, D, Chellini, E, Mallone, S, Accetta, G, Barchielli, A, Nuvolone, D, Baccini, M, Biggeri, A, Vigotti, MARIA ANGELA, Colais, P, Faustini, A, Forastiere, F, Perucci, Ca, Stafoggia, M, Minerba, S, Serinelli, M, Dessì, Pm, Cernigliaro, A, and Scondotto, S.

Subjects
Atmospheric pollution, interpretation of studies, review, human health
Published
2009

36. Ricoveri per cause respiratorie e inquinamento atmosferico in 9 città italiane. i risultati del progetto EPIAIR

Author

Gruppo collaborativo EpiAir Accetta G, Serinelli M. e., Baccini, M, Baldacci, S., Barchielli, A, Berti, G, Biggeri, A., Bisanti, L, Cadum, E., Caranci, N, Cernigliaro, A, Chellini, E., Chiusolo, M, Colais, P, De’Donato, F, Dessì, P, Faustini, A, Forastiere, F, Galassi, C, Grechi, D, Grosa, M, Ivaldi, C, Mallone, S, Miglio, R., Nuvolone, D, Pace, G., Pacelli, B, Pandolfi, P, Pelosini, R, Perucci, Ca, Poncino, S, Primerano, R, Randi, G, Rognoni, M, Scarnato, C, Scondotto, S, Serinelli, M, Simonato, L, Stafoggia, M, Tessari, R, Viegi, G, Vigotti, MARIA ANGELA, and Zanini, G.

Subjects
short term effect, air pollution, respiratory admissions, EPIAIR
Published
2009

38. EpiAir health data

Author

Galassi, C., Faustini, A., Colais, P., Stafoggia, M., Berti, G., Biggeri, A., Bisanti, L., Cernigliaro, A., Chiusolo, M., Mallone, S., Pandolfi, P., Sernelli, M., Tessari, R., Vigotti, M. A., Forastiere, F., and Gruppo collaborativo EpiAir

Published
2009

40. Inquinamento atmosferico e ricoveri ospedalieri urgenti per malattie cardiache in 9 città italiane – risultati del progetto EPIAIR

Author

il gruppo collaborativo EpiAir Accetta G, Colais P. e., Baccini, M, Baldacci, S., Barchielli, A, Berti, G, Biggeri, A., Bisanti, L, Cadum, E., Caranci, N, Cernigliaro, A, Chellini, E., Chiusolo, M, Colais, P, De’Donato, F, Dessì, P, Faustini, A, Forastiere, F, Galassi, C, Grechi, D, Grosa, M, Ivaldi, C, Mallone, S, Miglio, R., Nuvolone, D, Pace, G., Pacelli, B, Pandolfi, P, Pelosini, R, Perucci, Ca, Poncino, S, Primerano, R, Randi, G, Rognoni, M, Scarnato, C, Scondotto, S, Serinelli, M, Simonato, L, Stafoggia, M, Tessari, R, Viegi, G, Vigotti, MARIA ANGELA, and Zanini, G.

Subjects
hospital admissions, case crossover, air pollution, EPIAIR
Published
2009

41. Air Pollution and the Risk of Venous Thrombo-Embolism

Author

Colais, P, Faustini, A, Berti, G, Bisanti, L, Cernigliaro, A, Chiusolo, M, Mallone, S, Pandolfi, P, Perucci, Ca, Serinelli, M, Stafoggia, M, Tessari, R, Vigotti, MARIA ANGELA, Forastiere, F, and EPIAIR collaborative Group

Subjects
air pollution, cardiovascular health
Published
2009

42. Inquinamento atmosferico e mortalità in 10 città Italiane

Author

Stafoggia, M, Faustini, A, Rognoni, M, Tessari, R, Cadum, E, Pacelli, B, Pandolfi, P, Miglio, R, Mallone, S, Vigotti, MARIA ANGELA, Serinelli, M, Accetta, G, Dessi, Mp, Cernigliaro, A, Galassi, C, Berti, G, and Forastiere, F.

Subjects
case-crossover, air pollution, mortality, susceptibility
Published
2009

43. Does temperature modify the association between air pollution and mortality? A multicity case-crossover analysis in Italy

Author

Stafoggia, M, Schwartz, J, Forastiere, F, Perucci, Ca, SISTI GROUP AGOSTINI, D, DE LISIO, S, Miglio, R, Pandolfi, P, Scarnato, C, Simonato, L, Tessari, R, Bisanti, L, Rognoni, M, Russo, A, Cernigliaro, A, Scondotto, S, Vigotti, MARIA ANGELA, Belleudi, V, De'Donato, F, Michelozzi, P, Picciotto, S, Primerano, R, Serinelli, M, Berti, G, Cadum, E, Caranci, N, Chiusolo, M, and Demaria, M.

Subjects
Adult, Male, Urban Population, Epidemiology, Air pollution, association, climate, effect modifiers (epidemiology), environmental exposure, mortality, particulate matter, seasons, temperature, environmental exposure, medicine.disease_cause, law.invention, Animal science, CASE CROSSOVER, Risk Factors, law, Air Pollution, Cause of Death, effect modifiers (epidemiology), medicine, Humans, climate, particulate matter, Cross-Over Studies, seasons, association, temperature, Environmental exposure, Particulates, Atmospheric temperature, mortality, Confidence interval, Italy, Ventilation (architecture), Environmental science, Female, Risk of death
Abstract

Adverse health effects of particulate matter

Published
2008

44. Stima dell’incidenza dell’infarto miocardico acuto basata su dati sanitari correnti mediante un algoritmo comune in differenti aree italiane. In'Utilizzo epidemiologico di archivi sanitari elettronici correnti: un’esperienza di standardizzazione delle procedure per la stima di frequenza di alcune malattie in diverse aree italiane

Author

Barchielli, A, Balzi, D, Bruni, A, Canova, C, Cesaroni, G, Gnavi, R, Picariello, R, Inio, A, Protti, Ma, Romanelli, A, Tessari, R, Vigotti, MARIA ANGELA, and Simonato, L.

Subjects
incidence, acute myocardial infarction, record linkage, hospitalization, mortality
Published
2008

45. Obiettivi, strumenti e metodi per un utilizzo epidemiologico di archivi sanitari elettronici correnti in diverse aree italiane.[Obiectives, tools and methods for an epidemiological use of electronic health archives in various areas of Italy]

Author

Simonato, L, Baldi, I, Balzi, D, Barchielli, A, Battistella, G, Canova, C, Cesaroni, G, Corrao, G, Collini, F, Conti, S, Costa, Giuseppe, Demaria, M, Fornari, C, Faustini, A, Galassi, C, Gnavi, R, Inio, A, Madotto, F, Migliore, E, Minelli, G, Pellizzari, M, Protti, M, Romanelli, A, Russo, A, Saugo, M, Tancioni, V, Tessari, R, Vianello, A, and Vigotti, Ma

Published
2008

47. Obiettivi,strumenti e metodi per l’uso epidemiologico di archivi elettronici sanitari in diverse aree italiane

Author

Simonato, L, Baldi, I, Balzi, D, Barchielli, A, Battistella, G, Canova, C, Cesaroni, G, Corrao, G, Collini, F, Conti, S, Costa, G, Demaria, M, Fornari, C, Faustini, A, Galassi, C, Gnavi, R, Inio, A, Madotto, F, Migliore, E, Minelli, G, Pellizzari, M, Protti, M, Romanelli, A, Russo, A, Saugo, M, Tancioni, V, Tessari, R, Vianello, A, and Vigotti, MARIA ANGELA

Subjects
frequency estimates, electronic archives, record
Published
2008

49. PSS54 - HTA & MCDA In The Treatment of Macular Edema

Author

Ferrario, L, Foglia, E, Bandello, F, Ferri, C, Figini, I, Franzin, M, Gambaro, G, Introini, U, Staurenghi, G, Tadini, P, Zuppini, T, Tessari, R, Scarpa, G, Urban, F, Beltramini, S, Tobaldi, RF, Nicolò, M, Ancona, C, Moriconi, S, Nuti, E, Fusco, F, and Croce, D

Published
2017
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