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6. Minimal Links in the Cubic Lattice

Author

Uberti, R., van Rensburg, E. J. Janse, Orlandinit, E., Tesi, M. C., Whittington, S. G., Friedman, Avner, editor, Gulliver, Robert, editor, Whittington, Stuart G., editor, De Sumners, Witt, editor, and Lodge, Timothy, editor

Published
1998
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7. Primary Prostatic Adenocarcinoma in a Domestic Short-Haired Cat

Author

Tesi, M., Mannucci, T., Succi, M., Baldassarre, V., Rota, A., and Citi, S.

Subjects
Pathology, medicine.medical_specialty, Primary (chemistry), General Veterinary, Prostatic adenocarcinoma, business.industry, Carcinoma, Cat, Computed tomography, Immunohistochemistry, Prostate, Uroplakin, Medicine, business
Abstract

An 8-years-old, domestic short-haired cat was presented for constipation and symptoms referable to the lower urinary tract. A solid mass located in the caudal area of the abdomen was palpated. Abdominal ultrasonography, positive-contrast retrograde urethrocystography and total body computed tomography showed the presence of a prostatic neoformation occupying almost completely the pelvic cavity. The neoformation displaced dorsolaterally the descending colon and completely englobed the prostatic urethra, without apparent involvement of the urethral lumen. Histopathologic examination revealed a prostatic carcinoma. Neoplastic cells showed a moderate to intense cytoplasmatic expression of AE1/AE3, while no expression of cytokeratin 7 and Uroplakin III was observed. Topographical, histological and immunohistochemical findings were consistent with a diagnosis of primary adenocarcinoma of the prostate body

Published
2021

8. Topology and Geometry of Biopolymers

Author

van Rensburg, E. J. Janse, Orlandini, Enzo, Sumners, De Witt, Tesi, M. Carla, Whittington, Stuart G., Friedman, Avner, editor, Gulliver, Robert, editor, Mesirov, Jill P., editor, Schulten, Klaus, editor, and Sumners, De Witt, editor

Published
1996
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9. Towards a proton imaging system

Author

Civinini, C., Brianzi, M., Bruzzi, M., Bucciolini, M., Candiano, G., Capineri, L., Cirrone, G.A.P., Cuttone, G., Lo Presti, D., Marrazzo, L., Mazzaglia, E., Menichelli, D., Pieri, S., Randazzo, N., Sipala, V., Stancampiano, C., Talamonti, C., Tesi, M., and Valentini, S.

Published
2010
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21. The PAMELA silicon tracker

Author

Straulino, S., Adriani, O., Bonechi, L., Bongi, M., Castellini, G., D'Alessandro, R., Gabbanini, A., Grandi, M., Papini, P., Ricciarini, S.B., Spillantini, P., Taccetti, F., Tesi, M., and Vannuccini, E.

Published
2004
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31. Pamela tracking system: status report

Author

Taccetti, F., Adriani, O., Bonechi, L., Bongi, M., Boscherini, M., Castellini, G., D’Alessandro, R., Gabbanini, A., Grandi, M., Papini, P., Piccardi, S., Ricciarini, S., Spillantini, P., Straulino, S., Tesi, M., and Vannuccini, E.

Published
2002
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32. The PAMELA experiment on satellite and its capability in cosmic rays measurements

Author

Adriani, O, Ambriola, M, Barbarino, G, Barbier, L.M, Bartalucci, S, Bazilevskaja, G, Bellotti, R, Bertazzoni, S, Bidoli, V, Boezio, M, Bogomolov, E, Bonechi, L, Bonvicini, V, Boscherini, M, Bravar, U, Cafagna, F, Campana, D, Carlson, P, Casolino, M, Castellano, M, Castellini, G, Christian, E.R, Ciacio, F, Circella, M, D'Alessandro, R, De Marzo, C.N, De Pascale, M.P, Finetti, N, Furano, G, Gabbanini, A, Galper, A.M, Giglietto, N, Grandi, M, Grigorjeva, A, Guarino, F, Hof, M, Koldashov, S.V, Korotkov, M.G, Krizmanic, J.F, Krutkov, S, Lund, J, Marangelli, B, Marino, L, Menn, W, Mikhailov, V.V, Mirizzi, N, Mitchell, J.W, Mocchiutti, E, Moiseev, A.A, Morselli, A, Mukhametshin, R, Ormes, J.F, Osteria, G, Ozerov, J.V, Papini, P, Pearce, M, Perego, A, Piccardi, S, Picozza, P, Ricci, M, Salsano, A, Schiavon, P, Scian, G, Simon, M, Sparvoli, R, Spataro, B, Spillantini, P, Spinelli, P, Stephens, S.A, Stochaj, S.J, Stozhkov, Y, Straulino, S, Streitmatter, R.E, Taccetti, F, Tesi, M, Vacchi, A, Vannuccini, E, Vasiljev, G, Vignoli, V, Voronov, S.A, Yurkin, Y, Zampa, G, and Zampa, N

Published
2002
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36. The PRIMA (PRoton IMAging) collaboration: Development of a proton Computed Tomography apparatus

Author

Scaringella, M, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Scaringella M, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Scaringella, M, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Scaringella M, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

This paper describes the development of a proton Computed Tomography (pCT) apparatus able to reconstruct a map of stopping power useful for accurate proton therapy treatment planning and patient positioning. This system is based on two main components: a silicon microstrip tracker and a YAG:Ce crystal calorimeter. Each proton trajectory is sampled by the tracker in four points: two upstream and two downstream the object under test; the particle residual energy is measured by the calorimeter. The apparatus is described in details together with a discussion on the characterization of the hardware under proton beams with energies up to 175 MeV.

Published
2013

37. A proton Computed Tomography system for medical applications

Author

Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Sipala, V, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, SIPALA, Valeria, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) can improve the accuracy of both patient positioning and dose calculation in proton therapy, enabling to accurately reconstruct the electron density distribution of irradiated tissues. A pCT prototype, equipped with a silicon tracker and a YAG:Ce calorimeter, has been manufactured by an Italian collaboration. First tests under proton beam allowed obtaining good quality tomographic images of a non-homogeneous phantom. Manufacturing of a new large area system with real-time data acquisition is under way.

Published
2013

38. Towards a large area apparatus for Proton Computed Tomography

Author

Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi, M., Brianzi, M., Bucciolini, M., CARPINELLI, Massimo, Civinini, C., Cuttone, G., Lo Presti, D., Pallotta, S., Pugliatti, C., Randazzo, N., Romano, F., Scaringella, M., SIPALA, Valeria, Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., Zani, M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi, M., Brianzi, M., Bucciolini, M., CARPINELLI, Massimo, Civinini, C., Cuttone, G., Lo Presti, D., Pallotta, S., Pugliatti, C., Randazzo, N., Romano, F., Scaringella, M., SIPALA, Valeria, Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., and Zani, M.

Abstract

Proton Computed Tomography (pCT) is a new imaging method with a potential for increasing accuracy of treatment planning and patient positioning in hadron therapy. A pCT system with small active area (5cm×5cm) has been already manufactured by authors. Tested under proton beams gave first promising results on radiography and tomographic reconstructions. Recent developments of a second prototype with large area (5×20cm2) in the perspective of a pre-clinical acquisition system is now being designed, details are given in this paper.

Published
2013

39. A binary readout chip for silicon microstrip detector in proton imaging application

Author

Sipala, V., primary, Bruzzi, M., additional, Bondì, M., additional, Bonanno, D., additional, Cadeddu, S., additional, Carpinelli, M., additional, Cirrone, G.A.P., additional, Civinini, C., additional, Cuttone, G., additional, Lai, A., additional, Leonora, E., additional, Presti, D. Lo, additional, Maccioni, G., additional, Pallotta, S., additional, Randazzo, N., additional, Scaringella, M., additional, Talamonti, C., additional, Tesi, M., additional, and Vanzi, E., additional

Published
2017
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40. The PRIMA (Proton Imaging) collaboration: Status of the development of a proton Computed Tomography Scanner

Author

Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

The PRIMA (Proton IMAging) experiment is aimed at developing a proton Computed Tomography (pCT) prototype based on tracking single protons. Approaches to the pCT consist in the use of silicon microstrip detectors to measure the position and direction of individual protons before and after they traverse the phantom, in view to reconstruct the trajectory of each proton, and a calorimeter for measuring particle residual energy. A small prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography, were carried out during these beam tests. Radiographies have been reconstructed with different methods: results show the good performances of the device, with spatial resolution fulfilling the stringent requirements of a pCT device.

Published
2012

41. Development of a Proton Computed Tomography System for Pre-Clinical Tests

Author

Civinini, C, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Civinini C, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Civinini, C, Brianzi, M, Bruzzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Scaringella, M, Sipala, V, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, Zani, M, Civinini C, Brianzi M, Bruzzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, Scaringella M, SIPALA, Valeria, Stancampiano C, Talamonti C, Tesi M, Vanzi E, and Zani M.

Abstract

Proton Computed Tomography (pCT) is an imaging method under investigation with the aim to improve the accuracy of treatment planning and patient positioning in hadron therapy. A pCT system should be capable to measure tissue electron density with an accuracy better than 1% and with a spatial resolution better than 1mm. A first apparatus based on a silicon tracker and a YAG:Ce crystal calorimeter, with a 5×5 cm2 active area, has been already developed by the authors in the framework of the PRIMA (Proton Imaging) collaboration and tested with proton beams with promising results. A second prototype with larger area (5×20 cm2) and improved data acquisition system is being designed. The details about this new prototype will be presented in this work.

Published
2012

42. The PRIMA (Proton Imaging) collaboration: Status of the development of a proton Computed Tomography Scanner

Author

Bruzzi M, Brianzi M, Bucciolini M, CARPINELLI, Massimo, Cirrone GAP, Civinini C, Cuttone G, Lo Presti D, Pallotta S, Pugliatti C, Randazzo N, Romano F, SIPALA, Valeria, Scaringella M, Stancampiano C, Talamonti C, Tesi M, Vanzi E, Zani M., Bruzzi, M, Brianzi, M, Bucciolini, M, Carpinelli, M, Cirrone, G, Civinini, C, Cuttone, G, Lo Presti, D, Pallotta, S, Pugliatti, C, Randazzo, N, Romano, F, Sipala, V, Scaringella, M, Stancampiano, C, Talamonti, C, Tesi, M, Vanzi, E, and Zani, M

Subjects
Spatial resolution, Silicon detector, Proton computed tomography (pCT), Network security, Proton computed tomography, Computerized tomography, Proton beam, Radiography, Silicon micro-strip detector, Experiment, Nuclear physic, Residual energy, Medical imaging, Proton, Proton imaging, Stringent requirement, Data privacy, Beam test
Abstract

The PRIMA (Proton IMAging) experiment is aimed at developing a proton Computed Tomography (pCT) prototype based on tracking single protons. Approaches to the pCT consist in the use of silicon microstrip detectors to measure the position and direction of individual protons before and after they traverse the phantom, in view to reconstruct the trajectory of each proton, and a calorimeter for measuring particle residual energy. A small prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography, were carried out during these beam tests. Radiographies have been reconstructed with different methods: results show the good performances of the device, with spatial resolution fulfilling the stringent requirements of a pCT device.

Published
2012

43. Total Dose Test of Commercial Off-The-Shelf Components To Be Used in Power Supply for Space Experiments

Author

Menichelli, M., Battiston, R., Bizzaglia, S., Blasko, S., Castellini, G., Di Masso, L., Gabbanini, A., Papi, A., Scolieri, G., and Tesi, M.

Subjects
Nuclear research -- Observations, Power supply (Electronics) -- Observations, Business, Electronics, Electronics and electrical industries
Abstract

Commercial off-the-shelf components have been tested for their use on the power supplies of the AMS and PAMELA experiments. The test has been performed using the CALLIOPE Co60 source at the Casaccia (Rome -Italy) Laboratory of ENEA according to the ESA/SCC 22900 specifications. The total dose for this test was 30 krads. Measurements of relevant parameters for each component has been taken at 3, 10 and 30 krads. Annealing and ageing has also been perfomed according to the ESA specification. The results on the degradation of performaces in discrete transistors, Op-Amps, regulators and other analog and digital components are reported.

Published
2000

44. PRIMA+: A proton Computed Tomography apparatus

Author

Civinini, C., Bruzzi, M., Bucciolini, M., Cirrone, G. A. P., Cuttone, G., Lo Presti, D., Pallotta, S., Randazzo, N., Scaringella, M., Sipala, V., Stancampiano, C., Talamonti, C., Tesi, M., Vanzi, E., and Zani, M.

Published
2013

46. Proton imaging apparatus for protontherapy application

Author

Sipala, V., Brianzi, M., Bruzzi, M., Bucciolini, M., Cirrone, G. A. P., Civinini, C., Cuttone, G., LO PRESTI, Domenico, Randazzo, N., Scaringella, M., Stancampiano, C., Talamonti, C., and Tesi, M.

Published
2011

47. Readout Electronics for a Proton Tomography Apparatus

Author

Menichelli, D., Capineri, L., Civinini, C., Fucile, A., Presti, D. LO, Randazzo, N., Russo, M., Sipala, V., Tesi, M., and Valentini, S.

Subjects
medical imaging, fast acquisition electronics, nuclear medicine, silicon detector
Published
2007

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