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194 results on '"Tesfaye, Anteneh"'

9. A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal CancerPD-L1/CTLA-4 Inhibition with Radiation for Colorectal Cancer

Author

Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, F Stephen, and Schoenfeld, Jonathan D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Immunotherapy, Radiation Oncology, Clinical Research, Cancer, Clinical Trials and Supportive Activities, Digestive Diseases, Colo-Rectal Cancer, Antineoplastic Combined Chemotherapy Protocols, B7-H1 Antigen, Biomarkers, CTLA-4 Antigen, Colorectal Neoplasms, Combined Modality Therapy, Gene Expression Profiling, Humans, Immune Checkpoint Inhibitors, Molecular Targeted Therapy, Neoplasm Metastasis, Neoplasm Staging, Radiation Dose Hypofractionation, Treatment Outcome, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeProspective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4 blockade.Patients and methodsWe performed a multicenter phase II study randomly assigning patients with metastatic microsatellite stable colorectal cancer to repeated low-dose fractionated radiation (LDFRT) or hypofractionated radiation (HFRT) with PD-L1/CTLA-4 inhibition. The primary endpoint was response outside the radiation field. Correlative samples were analyzed using multiplex immunofluorescence (IF), IHC, RNA/T-cell receptor (TCR) sequencing, cytometry by time-of-flight (CyTOF), and Olink.ResultsEighteen patients were evaluable for response. Median lines of prior therapy were four (range, 1-7). Sixteen patients demonstrated toxicity potentially related to treatment (84%), and 8 patients had grade 3-4 toxicity (42%). Best response was stable disease in 1 patient with out-of-field tumor shrinkage. Median overall survival was 3.8 months (90% confidence interval, 2.3-5.7 months). Correlative IF and RNA sequencing (RNA-seq) revealed increased infiltration of CD8+ and CD8+/PD-1+/Ki-67+ T cells in the radiation field after HFRT. LDFRT increased foci of micronuclei/primary nuclear rupture in two subjects. CyTOF and RNA-seq demonstrated significant declines in multiple circulating immune populations, particularly in patients receiving HFRT. TCR sequencing revealed treatment-associated changes in T-cell repertoire in the tumor and peripheral blood.ConclusionsWe demonstrate the feasibility and safety of adding LDFRT and HFRT to PD-L1/CTLA-4 blockade. Although the best response of stable disease does not support the use of concurrent PD-L1/CTLA-4 inhibition with HFRT or LDFRT in this population, biomarkers provide support that both LDFRT and HFRT impact the local immune microenvironment and systemic immunogenicity that can help guide future studies.

Published
2021

14. Phase II trial of BXCL701 and pembrolizumab in patients with metastatic pancreatic ductal adenocarcinoma (EXPEL-PANC): Preliminary findings.

Author

Weinberg, Benjamin Adam, primary, Lekan, Alexander, additional, Fitzgerald, Allison, additional, Malchiodi, Zoe, additional, Gutierrez, Martin, additional, Tesfaye, Anteneh A., additional, Tan, Ming Tony, additional, Noel, Marcus Smith, additional, He, Aiwu Ruth, additional, Mukherji, Reetu, additional, Marshall, John, additional, Jones, Princess, additional, Borderies, Pascal, additional, O'Neill, Vincent, additional, and Weiner, Louis M., additional

Published
2024
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15. List of contributors

Author

Al-e-Ahmad, Atiyeh, primary, Al-Hallak, Najeeb, additional, Al-Share, Bayan, additional, Awasthee, Nikee, additional, Azmi, Asfar S., additional, Bande, Manuel F., additional, Baruah, Pranjal K., additional, Barwal, Tushar Singh, additional, Bazala, Sonali, additional, Blanco-Teijeiro, María José, additional, Challagundla, Kishore B., additional, Chhabra, Ravindresh, additional, David, Antoine, additional, Demirkhanyan, Lusine, additional, Fawzy, Manal S., additional, Fernandez-Diaz, Daniel, additional, Fernandez-Marta, Beatriz, additional, Garrick, David, additional, Gondi, Christopher S., additional, Goodhardt, Michele, additional, Gougelet, Angélique, additional, Goyal, Bela, additional, Grabowska, Małgorzata, additional, Gupta, Amit, additional, Gupta, Subash C., additional, Gupta, Sweety, additional, Gupta, Tarunima, additional, Haidari, Muhib, additional, Jain, Aklank, additional, Kerachian, Mohammad Amin, additional, Kumar, Ajay, additional, Kumar, Santosh, additional, Lago-Baameiro, Nerea, additional, Misiorek, Julia O., additional, Moudi, Emadoddin, additional, Murmu, Masang, additional, Neamati, Nahid, additional, Neyol, Priyasha, additional, Paniagua, Laura, additional, Pardo, María, additional, Parsian, Hadi, additional, Pathania, Anup S., additional, Piñeiro, Antonio, additional, Prathipati, Philip, additional, Rai, Vipin, additional, Rolle, Katarzyna, additional, Sanceau, Julie, additional, Sedhom, Jessica A., additional, Sexton, Rachel, additional, Sharma, Anurag, additional, Sharma, Uttam, additional, Shekher, Anusmita, additional, Silva-Rodríguez, Paula, additional, Singh, Ipsa, additional, Smith, Oghenetejiri V., additional, Tesfaye, Anteneh, additional, Toraih, Eman A., additional, Vishvakarma, Naveen Kumar, additional, Younesi, Simin, additional, Zarębska, Żaneta, additional, and Zocchi, Simone, additional

Published
2022
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25. Contributors

Author

Ahmed, Ishfaq, primary, Akhtar, Sabah, additional, Almalki, Atiah H., additional, Al-Naemi, Hamda A., additional, Al-Qambar, Batool, additional, Alsaab, Hashem O., additional, Althobaiti, Yusuf S., additional, Alzhrani, Rami, additional, Annageldiyev, C, additional, Azmi, Asfar S., additional, Batra, Surinder K., additional, Bialt-DeCelie, Meghan, additional, Blocker, Stephanie J., additional, Bolland, Danielle E., additional, Chaker, Mahmoud, additional, Chang, Hui-Hua, additional, Choi, Minsig, additional, Claxton, D.C., additional, Eibl, Guido, additional, Fadel, Hassan, additional, Ganguly, Koelina, additional, Gardner, Heather L., additional, Haley, John D., additional, Haris, Mohammad, additional, Iyer, Arun K., additional, Kamgar, Mandana, additional, Kaur, Sukhwinder, additional, Khan, Abdul Q., additional, Khan, Rehan, additional, Klinger, Neil, additional, Kolb, Bradley, additional, Kuttikrishnan, Shilpa, additional, Li, Yiwei, additional, Londhe, Priya, additional, London, Cheryl A., additional, Madhunapantula, S.V., additional, Majumdar, Adhip P.N., additional, Masood, Ashiq, additional, McHugh, Christopher I., additional, McLean, Karen, additional, Mittal, Sandeep, additional, Mohammad, Ramzi M., additional, Mraiche, Fatima, additional, Muqbil, Irfana, additional, Patel, T.N., additional, Pappas, Sam G., additional, Philip, Philip A., additional, Prabhu, Kirti S., additional, Rashid, Khalid, additional, Raza, Syed Shadab, additional, Sau, Samaresh, additional, Shanmugakonar, Muralitharan, additional, Sharma, A, additional, Shields, Anthony F., additional, Shukla, Surendra Kumar, additional, Singh, Pankaj Kumar, additional, Siveen, Kodappully S., additional, Tesfaye, Anteneh, additional, Uddin, Shahab, additional, Uwe-Wagner, Kay, additional, and Viola-Villegas, Nerissa, additional

Published
2019
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26. Physical and Chemical Properties of Highland Bamboo (Yushania alpina) Culms Grown in Ethiopia

Author

Mussa, Mahadi, Desalegn, Getachew, Kaba, Gemechu, Tesfaye, Anteneh, Mussa, Mahadi, Desalegn, Getachew, Kaba, Gemechu, and Tesfaye, Anteneh

Abstract

Bamboo is the fastest growing plant currently known on earth, a property that enables it to be the best alternative as a future source of wood fi ber. This study investigated the effect of site and culm height on the physical and chemical properties of Yushania alpina culms grown in Ethiopia. Matured Yushania alpina 3 to 5-year-old samples were harvested from Hagere-Selam and Rebu-Gebeya sites. The culms were subdivided into three equal lengths (bottom, middle, and top), and the variations in physical and chemical properties between the two sites and the culm heights of Yushania alpina were investigated. The results showed that the average values of MC, basic density, tangential and longitudinal shrinkage of Yushania alpina culms for Hagere-Selam and Rebu-Gebeya sites were (91.78 and 80.32 %), (0.65 and 0.63 g/cm3), (6.63 and 5.84 %) and (0.63 and 0.56 %), respectively. The average values of cellulose, lignin, extractive and ash contents in the culms for Hagere-Selam and Rebu-Gebeya sites were (52.84 and 50.71 %), (26.55, and 26.04 %), (8.41 and 8.02 %) and (1.95 and 2.17 %), respectively. The results revealed that the site affected the MC, basic density, cellulose, lignin, extractive, and ash contents of Yushania alpina culms but not the tangential and longitudinal shrinkage. The culm height of Yushania alpina affected MC, basic density, tangential shrinkage, longitudinal shrinkage, cellulose, lignin, extractive, and ash contents. In the case of both sites, the highest percentages of MC, tangential and longitudinal shrinkage, and ash content were observed at the base and lowest at the top of the culms. On the contrary, both sites observed thehighest magnitude of basic density, cellulose and extractive at the top and lowest at the base of the culms. The variations in physical and chemical properties at different sites and culm heights infl uence the utilization of Yushania alpina culms for industries and end products., Bambus je trenutačno najbrže rastuća biljka u svijetu, što je čini najboljom alternativom za budući izvor drvnih vlakana. Ovom je studijom istraživan utjecaj staništa i visine bambusa Yushania alpina, uzgojenoga u Etiopiji, na fizička i kemijska svojstva njegove stabljike. Uzorci Yushania alpina stari tri do pet godina skupljeni su sa staništa Hagere-Selam i Rebu-Gebeya. Stabljike su podijeljene na tri jednake duljine (baza, sredina i vrh) na kojima su istraživane varijacije fizičkih i kemijskih svojstava stabljike s obzirom na dva staništa i visinu bambusa. Rezultati su pokazali da su prosječne vrijednosti sadržaja vode, gustoće te tangentnoga i uzdužnog utezanja stabljike Yushania alpina sa staništa Hagere-Selam i Rebu-Gebeya bile 91,78 i 80,32 %; 0,65 i 0,63 g/cm3; 6,63 i 5,84 % te 0,63 i 0,56 %, a prosječne vrijednosti sadržaja celuloze, lignina, ekstraktiva i pepela sa staništa Hagere-Selam i Rebu-Gebeya bile su 52,84 i 50,71 %; 26,55 i 26,04 %; 8,41 i 8,02 % te 1,95 i 2,17 %. Rezultati su pokazali da je stanište utjecalo na sadržaj vode, gustoću te sadržaj celuloze, lignina, ekstraktiva i pepela u stabljikama Yushania alpina, ali ne i na tangentno i uzdužno utezanje. Visina stabljike Yushania alpina utjecala je na sadržaj vode, gustoću, tangentno i uzdužno utezanje te na sadržaj celuloze, lignina, ekstraktiva i pepela. Za oba staništa utvrđen je najveći sadržaj vode, tangentno i uzdužno utezanje te sadržaj pepela u bazi stabljike, a najmanji u vrhu stabljike. Nadalje, u vrhu stabljike s oba staništa primijećena je najveća gustoća, sadržaj celuloze i ekstraktiva, a najmanje su vrijednosti izmjerene u bazi stabljike. Varijacije fizičkih i mehaničkih svojstava s obzirom na stanište i visinu stabljike utječu na upotrebu stabljike Yushania alpina u industriji i za završne proizvode.

Published
2023

28. Supplementary Figure 8 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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29. Supplementary Figure 7 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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30. Supplementary Figure 2 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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31. Supplementary Figure 1 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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32. Data from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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33. Supplementary Figure 6 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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34. Supplementary Figure 4 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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35. Supplementary Figure 5 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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36. Supplementary Figure 3 from Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Author

Gabrielson, Andrew, primary, Wu, Yunan, primary, Wang, Hongkun, primary, Jiang, Jiji, primary, Kallakury, Bhaskar, primary, Gatalica, Zoran, primary, Reddy, Sandeep, primary, Kleiner, David, primary, Fishbein, Thomas, primary, Johnson, Lynt, primary, Island, Eddie, primary, Satoskar, Rohit, primary, Banovac, Filip, primary, Jha, Reena, primary, Kachhela, Jaydeep, primary, Feng, Perry, primary, Zhang, Tiger, primary, Tesfaye, Anteneh, primary, Prins, Petra, primary, Loffredo, Christopher, primary, Marshall, John, primary, Weiner, Louis, primary, Atkins, Michael, primary, and He, Aiwu Ruth, primary

Published
2023
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37. Supplementary Table S3 from Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Author

Loree, Jonathan M., primary, Wang, Yucai, primary, Syed, Muddassir A., primary, Sorokin, Alexey V., primary, Coker, Oluwadara, primary, Xiu, Joanne, primary, Weinberg, Benjamin A., primary, Vanderwalde, Ari M., primary, Tesfaye, Anteneh, primary, Raymond, Victoria M., primary, Miron, Benjamin, primary, Tarcic, Gabi, primary, Zelichov, Ori, primary, Broaddus, Russell R., primary, Ng, Patrick Kwok Shing, primary, Jeong, Kang Jin, primary, Tsang, Yiu Huen, primary, Mills, Gordon B., primary, Overman, Michael J., primary, Grothey, Axel, primary, Marshall, John L., primary, and Kopetz, Scott, primary

Published
2023
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38. Supplementary Data from Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma

Author

Azmi, Asfar S., primary, Khan, Husain Yar, primary, Muqbil, Irfana, primary, Aboukameel, Amro, primary, Neggers, Jasper E., primary, Daelemans, Dirk, primary, Mahipal, Amit, primary, Dyson, Gregory, primary, Kamgar, Mandana, primary, Al-Hallak, Mohammad Najeeb, primary, Tesfaye, Anteneh, primary, Kim, Steve, primary, Shidham, Vinod, primary, M. Mohammad, Ramzi, primary, and Philip, Philip A., primary

Published
2023
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39. Supplementary Data from A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer

Author

Monjazeb, Arta M., primary, Giobbie-Hurder, Anita, primary, Lako, Ana, primary, Thrash, Emily M., primary, Brennick, Ryan C., primary, Kao, Katrina Z., primary, Manuszak, Claire, primary, Gentzler, Ryan D., primary, Tesfaye, Anteneh, primary, Jabbour, Salma K., primary, Alese, Olatunji B., primary, Rahma, Osama E., primary, Cleary, James M., primary, Sharon, Elad, primary, Mamon, Harvey J., primary, Cho, May, primary, Streicher, Howard, primary, Chen, Helen X., primary, Ahmed, Mansoor M., primary, Mariño-Enríquez, Adrian, primary, Kim-Schulze, Seunghee, primary, Gnjatic, Sacha, primary, Maverakis, Emanual, primary, Marusina, Alina I., primary, Merleev, Alexander A., primary, Severgnini, Mariano, primary, Pfaff, Kathleen L., primary, Lindsay, James, primary, Weirather, Jason L., primary, Ranasinghe, Srinika, primary, Spektor, Alexander, primary, Rodig, Scott J., primary, Hodi, F. Stephen, primary, and Schoenfeld, Jonathan D., primary

Published
2023
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40. Supplementary Figure S1 from Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Author

Loree, Jonathan M., primary, Wang, Yucai, primary, Syed, Muddassir A., primary, Sorokin, Alexey V., primary, Coker, Oluwadara, primary, Xiu, Joanne, primary, Weinberg, Benjamin A., primary, Vanderwalde, Ari M., primary, Tesfaye, Anteneh, primary, Raymond, Victoria M., primary, Miron, Benjamin, primary, Tarcic, Gabi, primary, Zelichov, Ori, primary, Broaddus, Russell R., primary, Ng, Patrick Kwok Shing, primary, Jeong, Kang Jin, primary, Tsang, Yiu Huen, primary, Mills, Gordon B., primary, Overman, Michael J., primary, Grothey, Axel, primary, Marshall, John L., primary, and Kopetz, Scott, primary

Published
2023
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42. Optimization of bioethanol production from sugarcane molasses by the response surface methodology using Meyerozyma caribbica isolate MJTm3

Author

Hawaz, Estifanos, primary, Tafesse, Mesfin, additional, Tesfaye, Anteneh, additional, Kiros, Solomon, additional, Beyene, Dereje, additional, Kebede, Gessese, additional, Boekhout, Teun, additional, Groenewald, Marizeth, additional, Theelen, Bart, additional, Degefe, Ayantu, additional, Degu, Sisay, additional, Admasu, Alene, additional, Hunde, Biru, additional, and Muleta, Diriba, additional

Published
2022
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47. Correction: A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer

Author

Monjazeb, Arta M., primary, Giobbie-Hurder, Anita, additional, Lako, Ana, additional, Thrash, Emily M., additional, Brennick, Ryan C., additional, Kao, Katrina Z., additional, Manuszak, Claire, additional, Gentzler, Ryan D., additional, Tesfaye, Anteneh, additional, Jabbour, Salma K., additional, Alese, Olatunji B., additional, Rahma, Osama E., additional, Cleary, James M., additional, Sharon, Elad, additional, Mamon, Harvey J., additional, Cho, May, additional, Streicher, Howard, additional, Chen, Helen X., additional, Ahmed, Mansoor M., additional, Mariño-Enríquez, Adrian, additional, Kim-Schulze, Seunghee, additional, Gnjatic, Sacha, additional, Maverakis, Emanual, additional, Marusina, Alina I., additional, Merleev, Alexander A., additional, Severgnini, Mariano, additional, Pfaff, Kathleen L., additional, Lindsay, James, additional, Weirather, Jason L., additional, Ranasinghe, Srinika, additional, Spektor, Alexander, additional, Rodig, Scott J., additional, Hodi, F. Stephen, additional, and Schoenfeld, Jonathan D., additional

Published
2021
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48. Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Author

Loree, Jonathan M., primary, Wang, Yucai, additional, Syed, Muddassir A., additional, Sorokin, Alexey V., additional, Coker, Oluwadara, additional, Xiu, Joanne, additional, Weinberg, Benjamin A., additional, Vanderwalde, Ari M., additional, Tesfaye, Anteneh, additional, Raymond, Victoria M., additional, Miron, Benjamin, additional, Tarcic, Gabi, additional, Zelichov, Ori, additional, Broaddus, Russell R., additional, Ng, Patrick Kwok Shing, additional, Jeong, Kang Jin, additional, Tsang, Yiu Huen, additional, Mills, Gordon B., additional, Overman, Michael J., additional, Grothey, Axel, additional, Marshall, John L., additional, and Kopetz, Scott, additional

Published
2021
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49. A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer.

Author

Monjazeb, Arta M, Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, Stephen F, Schoenfeld, Jonathan D, Monjazeb, Arta M, Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, Stephen F, and Schoenfeld, Jonathan D

Abstract

PurposeProspective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4 blockade.Patients and methodsWe performed a multicenter phase II study randomly assigning patients with metastatic microsatellite stable colorectal cancer to repeated low-dose fractionated radiation (LDFRT) or hypofractionated radiation (HFRT) with PD-L1/CTLA-4 inhibition. The primary endpoint was response outside the radiation field. Correlative samples were analyzed using multiplex immunofluorescence (IF), IHC, RNA/T-cell receptor (TCR) sequencing, cytometry by time-of-flight (CyTOF), and Olink.ResultsEighteen patients were evaluable for response. Median lines of prior therapy were four (range, 1-7). Sixteen patients demonstrated toxicity potentially related to treatment (84%), and 8 patients had grade 3-4 toxicity (42%). Best response was stable disease in 1 patient with out-of-field tumor shrinkage. Median overall survival was 3.8 months (90% confidence interval, 2.3-5.7 months). Correlative IF and RNA sequencing (RNA-seq) revealed increased infiltration of CD8+ and CD8+/PD-1+/Ki-67+ T cells in the radiation field after HFRT. LDFRT increased foci of micronuclei/primary nuclear rupture in two subjects. CyTOF and RNA-seq demonstrated significant declines in multiple circulating immune populations, particularly in patients receiving HFRT. TCR sequencing revealed treatment-associated changes in T-cell repertoire in the tumor and peripheral blood.ConclusionsWe demonstrate the feasibility and safety of adding LDFRT and HFRT to PD-L1/CTLA-4 blockade. Although the best response of stable disease does not support the use of concurrent PD-L1/CTLA-4 inhibition with HFRT or LDFRT in this population, biomarkers provide support that both LDFRT and HFRT impact the local immune microenvironment and systemic immunogenicity that can help guide future studies.

Published
2021

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