285 results on '"Terstappen, Georg C."'
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2. Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
3. Combining experimental strategies for successful target deconvolution
4. Strategies for delivering therapeutics across the blood–brain barrier
5. Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model
6. Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study
7. Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells
8. Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems
9. Drug Distribution into Peripheral Nerve
10. Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs
11. Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example
12. Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling
13. Label-free detection of small-molecule binding to a GPCR in the membrane environment
14. Targeting mutant huntingtin for the development of disease-modifying therapy
15. Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades
16. A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
17. Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
18. A Primer on Screening Data Management
19. Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders
20. Small molecule drug discovery for Huntington's Disease
21. Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625
22. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity
23. Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification
24. In vitro screening strategies for nicotinic receptor ligands
25. A Bioinformatics Perspective on Proteomics: Data Storage, Analysis, and Integration
26. Phosphoproteome Analysis
27. A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells
28. Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels
29. The Wnt pathway, cell-cycle activation and [beta]-amyloid: novel therapeutic strategies in Alzheimer's disease?
30. Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development.
31. Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
32. Trafficking of JC virus-like particles across the blood–brain barrier
33. Screening technologies for ion channel drug discovery
34. Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease
35. Not a dilemma: target deconvolution in drug discovery
36. Ion channel screening technologies today
37. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
38. Editorial Note
39. Editorial Note
40. Cloud-Point Extraction of Gangliosides using Nonionic Detergent C14EO6
41. Functional Characterization of WNT7A Signaling in PC12 Cells: INTERACTION WITH A FZD5·LRP6 RECEPTOR COMPLEX AND MODULATION BY DICKKOPF PROTEINS
42. The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?
43. Molecular Cloning and Characterization of the Human Diacylglycerol Kinase β (DGKβ) Gene: ALTERNATIVE SPLICING GENERATES DGKβ ISOTYPES WITH DIFFERENT PROPERTIES
44. Pharmacological properties of rat α7 nicotinic receptors expressed in native and recombinant cell systems
45. Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line
46. Robust MS quantification method for phospho-peptides using 18O/16O labeling
47. In silico research in drug discovery
48. DISC761355_Supplementary_Material – Supplemental material for Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells
49. Identification, Gene Structure, and Expression of Human Frizzled-3 (FZD3)
50. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCβ1)
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