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136 results on '"Terstappen, Fieke"'

4. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis

Author

MS Verloskunde, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Infection & Immunity, Arts-assistenten Kinderen, Van De Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, Terstappen, Fieke, MS Verloskunde, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Infection & Immunity, Arts-assistenten Kinderen, Van De Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Published
2024

5. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis

Author

CDL Nanomedicine, Genetica, MS Verloskunde, Child Health, Circulatory Health, Onderzoek, van Kammen, Caren M, Taal, Seija E L, Wever, Kimberley E, Granger, Joey P, Lely, A Titia, Terstappen, Fieke, CDL Nanomedicine, Genetica, MS Verloskunde, Child Health, Circulatory Health, Onderzoek, van Kammen, Caren M, Taal, Seija E L, Wever, Kimberley E, Granger, Joey P, Lely, A Titia, and Terstappen, Fieke

Published
2024

6. Assessment of feto-placental oxygenation and perfusion in a rat model of placental insufficiency using T2* mapping and 3D dynamic contrast-enhanced MRI

Author

CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, MS Verloskunde, Child Health, Arts-assistenten Kinderen, Al Darwish, Fatimah M., Coolen, Bram F., van Kammen, Caren M., Alles, Lindy K., de Vos, Judith, Schiffelers, Raymond M., Lely, Titia A., Strijkers, Gustav J., Terstappen, Fieke, CDL Nanomedicine, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, MS Verloskunde, Child Health, Arts-assistenten Kinderen, Al Darwish, Fatimah M., Coolen, Bram F., van Kammen, Caren M., Alles, Lindy K., de Vos, Judith, Schiffelers, Raymond M., Lely, Titia A., Strijkers, Gustav J., and Terstappen, Fieke

Published
2024

7. Cerebroplacental ratio in low-risk pregnancies: the RATIO37 trial

Author

MS Verloskunde, Arts-assistenten Kinderen, Child Health, Circulatory Health, Meijerink, Lotte, Terstappen, Fieke, Depmann, Martine, Bekker, Mireille, Lely, Titia, MS Verloskunde, Arts-assistenten Kinderen, Child Health, Circulatory Health, Meijerink, Lotte, Terstappen, Fieke, Depmann, Martine, Bekker, Mireille, and Lely, Titia

Published
2024

8. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction:a systematic review and meta-analysis

Author

van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, Terstappen, Fieke, van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Abstract

Fetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency- induced FGR offspring. We included six animal and 49 human studies. Although unable to perform a meta-analysis of animal studies because of insufficient number of studies per individual outcome, all studies showed left ventricular dysfunction. Our meta-analyses of human studies revealed a reduced left ventricular mass, interventricular septum thickness, mitral annular peak velocity, and mitral lateral early diastolic velocity at neonatal age. No echocardiographic differences during childhood were observed, although the small age range and number of studies limited these analyses. Only two studies at adult age were performed. Meta-regression on other influential factors was not possible due to underreporting. The few studies on myocardial strain analysis showed small changes in global longitudinal strain in FGR offspring. The quality of the human studies was considered low and the risk of bias in animal studies was mostly unclear. Echocardiography may offer a noninvasive tool to detect early signs of cardiovascular predisposition following FGR. Clinical implementation yet faces multiple challenges including identification of the most optimal timing and the exact relation to long-term cardiovascular function in which echocardiography alone might be limited to reflect a child's vascular status. Future research should focus on myocardial strain analysis and the combination of other (non)imaging techniques for an improved risk estimation.

Published
2024

9. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis.

Author

Kammen, Caren M. van, Taal, Seija E. L., Wever, Kimberley E., Granger, Joey P., Lely, A. Titia, and Terstappen, Fieke

Subjects
FETAL growth retardation, PREECLAMPSIA, PHENOTYPIC plasticity, PERFUSION, BLOOD pressure
Abstract

The reduced uterine perfusion pressure (RUPP) model is frequently used to study preeclampsia and fetal growth restriction. An improved understanding of influential factors might improve reproducibility and reduce animal use considering the variability in RUPP phenotype. We performed a systematic review and meta-analysis by searching Medline and Embase (until 28 March, 2023) for RUPP studies in murine. Primary outcomes included maternal blood pressure (BP) or proteinuria, fetal weight or crown-rump length, fetal reabsorptions, or antiangiogenic factors. We aimed to identify influential factors by meta-regression analysis. We included 155 studies. Our meta-analysis showed that the RUPP procedure results in significantly higher BP (MD = 24.1 mmHg; [22.6; 25.7]; n = 148), proteinuria (SMD = 2.3; [0.9; 3.8]; n = 28), fetal reabsorptions (MD = 50.4%; [45.5; 55.2]; n = 42), circulating soluble FMS-like tyrosine kinase-1 (sFlt-1) (SMD = 2.6; [1.7; 3.4]; n = 34), and lower fetal weight (MD = −0.4 g; [−0.47; −0.34]; n = 113. The heterogeneity (variability between studies) in primary outcomes appeared ≥90%. Our meta-regression identified influential factors in the method and time point of BP measurement, randomization in fetal weight, and type of control group in sFlt-1. The RUPP is a robust model considering the evident differences in maternal and fetal outcomes. The high heterogeneity reflects the observed variability in phenotype. Because of underreporting, we observed reporting bias and a high risk of bias. We recommend standardizing study design by optimal time point and method chosen for readout measures to limit the variability. This contributes to improved reproducibility and thereby eventually improves the translational value of the RUPP model. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis.

Author

van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C. A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Subjects
FETAL growth retardation, GESTATIONAL age, GLOBAL longitudinal strain, ECHOCARDIOGRAPHY, VENTRICULAR septum
Abstract

Fetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency-induced FGR offspring. We included six animal and 49 human studies. Although unable to perform a meta-analysis of animal studies because of insufficient number of studies per individual outcome, all studies showed left ventricular dysfunction. Our meta-analyses of human studies revealed a reduced left ventricular mass, interventricular septum thickness, mitral annular peak velocity, and mitral lateral early diastolic velocity at neonatal age. No echocardiographic differences during childhood were observed, although the small age range and number of studies limited these analyses. Only two studies at adult age were performed. Meta-regression on other influential factors was not possible due to underreporting. The few studies on myocardial strain analysis showed small changes in global longitudinal strain in FGR offspring. The quality of the human studies was considered low and the risk of bias in animal studies was mostly unclear. Echocardiography may offer a noninvasive tool to detect early signs of cardiovascular predisposition following FGR. Clinical implementation yet faces multiple challenges including identification of the most optimal timing and the exact relation to long-term cardiovascular function in which echocardiography alone might be limited to reflect a child's vascular status. Future research should focus on myocardial strain analysis and the combination of other (non)imaging techniques for an improved risk estimation. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis

Author

Terstappen, Fieke, primary, Plösch, Torsten, additional, Calis, Jorg J.A., additional, Ganzevoort, Wessel, additional, Pels, Anouk, additional, Paauw, Nina D., additional, Gordijn, Sanne J., additional, van Rijn, Bas B., additional, Mokry, Michal, additional, and Lely, A. Titia, additional

Published
2023
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17. From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

Author

MS Verloskunde, Child Health, Circulatory Health, Onderzoek, Al Darwish, Fatimah M, Meijerink, Lotte, Coolen, Bram F, Strijkers, Gustav J, Bekker, Mireille, Lely, Titia, Terstappen, Fieke, MS Verloskunde, Child Health, Circulatory Health, Onderzoek, Al Darwish, Fatimah M, Meijerink, Lotte, Coolen, Bram F, Strijkers, Gustav J, Bekker, Mireille, Lely, Titia, and Terstappen, Fieke

Published
2023

18. Statins in pre-eclampsia or fetal growth restriction: A systematic review and meta-analysis on maternal blood pressure and fetal growth across species

Author

MS Verloskunde, Onderzoek, Child Health, Circulatory Health, Meijerink, Lotte, Wever, Kim E., Terstappen, Fieke, Ganzevoort, Wessel, Lely, A. Titia, Depmann, Martine, MS Verloskunde, Onderzoek, Child Health, Circulatory Health, Meijerink, Lotte, Wever, Kim E., Terstappen, Fieke, Ganzevoort, Wessel, Lely, A. Titia, and Depmann, Martine

Published
2023

23. Statins in pre‐eclampsia or fetal growth restriction: A systematic review and meta‐analysis on maternal blood pressure and fetal growth across species.

Author

Meijerink, Lotte, Wever, Kim E., Terstappen, Fieke, Ganzevoort, Wessel, Lely, A. Titia, and Depmann, Martine

Subjects
FETAL growth disorders, FETAL growth retardation, BLOOD pressure, FETAL development, PREECLAMPSIA, CORD blood
Abstract

Background: Several human randomised controlled trials (RCTs) are investigating the effects of statins on pre‐eclampsia (PE) and fetal growth restriction (FGR). This cross‐species meta‐analysis summarises the preclinical evidence of statin use for PE and FGR. Objectives: Evaluate the effects of statins on maternal blood pressure (MBP) and birthweight (BW) in pregnancies complicated by PE or FGR. Search Strategy: PubMed and Embase.com were searched on 10 May 2022 using 'statins' and 'pregnancy'. Selection Criteria: We included RCTs and cohorts with matched control groups as well as animal studies. Data Collection and Analysis: The main outcomes were MBP in mmHg and BW in grams. The standardised mean difference (SMD) with a 95% confidence interval (CI) was calculated. Subgroup analyses on species, statin, dose, timing and route of administration were performed if subgroups included at least three studies. Main Results: Our data included one human and 12 animal studies. Prenatal administration of statins significantly reduced MBP during pregnancy (SMD −2.49 mmHg [95% CI −4.26 to −0.71], p = 0.01). There was no significant effect of statins on BW (SMD 0.69 [95% CI −0.65 to 2.03], p = 0.28). Our subgroup analyses showed no effect on MBP of different doses, species or route of administration. Conclusions: Our cross‐species meta‐analyses demonstrate that statins only reduce maternal blood pressure in rodent pregnancies complicated by pre‐eclampsia or fetal growth restriction and have no effect on birthweight across species. The broad confidence intervals, inconsistent direction of the observed effects across the studies and large risk of bias lead us to conclude that a solid base for further human RCTs is lacking. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation—A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

Author

Terstappen, Fieke, primary, Richter, Anne E., additional, Lely, A. Titia, additional, Hoebeek, Freek E., additional, Elvan-Taspinar, Ayten, additional, Bos, Arend F., additional, Ganzevoort, Wessel, additional, Pels, Anouk, additional, Lemmers, Petra M., additional, and Kooi, Elisabeth M. W., additional

Published
2020
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38. Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation-A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

Author

MS Verloskunde, Child Health, Circulatory Health, DDOD, Brain, MS Neonatologie, Regenerative Medicine and Stem Cells, Terstappen, Fieke, Richter, Anne E, Lely, A Titia, Hoebeek, Freek E, Elvan-Taspinar, Ayten, Bos, Arend F, Ganzevoort, Wessel, Pels, Anouk, Lemmers, Petra M, Kooi, Elisabeth M W, MS Verloskunde, Child Health, Circulatory Health, DDOD, Brain, MS Neonatologie, Regenerative Medicine and Stem Cells, Terstappen, Fieke, Richter, Anne E, Lely, A Titia, Hoebeek, Freek E, Elvan-Taspinar, Ayten, Bos, Arend F, Ganzevoort, Wessel, Pels, Anouk, Lemmers, Petra M, and Kooi, Elisabeth M W

Published
2020

39. Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

Author

MS Verloskunde, Immuno/reuma onderzoek 5 (Vastert2), MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Onderzoek Precision medicine, Child Health, Terstappen, Fieke, Calis, Jorg J A, Paauw, Nina D, Joles, Jaap A, van Rijn, Bas B, Mokry, Michal, Plösch, Torsten, Lely, A Titia, MS Verloskunde, Immuno/reuma onderzoek 5 (Vastert2), MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Onderzoek Precision medicine, Child Health, Terstappen, Fieke, Calis, Jorg J A, Paauw, Nina D, Joles, Jaap A, van Rijn, Bas B, Mokry, Michal, Plösch, Torsten, and Lely, A Titia

Published
2020

40. Prenatal Amino Acid Supplementation to Improve Fetal Growth: A Systematic Review and Meta-Analysis

Author

MS Verloskunde, MMB opleiding Arts microbioloog, Infection & Immunity, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Child Health, Terstappen, Fieke, Tol, Angela J C, Gremmels, Hendrik, Wever, Kimberley E, Paauw, Nina D, Joles, Jaap A, Beek, Eline M van der, Lely, A Titia, MS Verloskunde, MMB opleiding Arts microbioloog, Infection & Immunity, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Child Health, Terstappen, Fieke, Tol, Angela J C, Gremmels, Hendrik, Wever, Kimberley E, Paauw, Nina D, Joles, Jaap A, Beek, Eline M van der, and Lely, A Titia

Published
2020

43. Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia

Author

MS Verloskunde, Arts-assistenten Kinderen, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Child Health, Terstappen, Fieke, Clarke, Sinéad M, Joles, Jaap A, Ross, Courtney A, Garrett, Michael R, Minnion, Magdalena, Feelisch, Martin, Goor, Harry van, Sasser, Jennifer M, Lely, A Titia, MS Verloskunde, Arts-assistenten Kinderen, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Child Health, Terstappen, Fieke, Clarke, Sinéad M, Joles, Jaap A, Ross, Courtney A, Garrett, Michael R, Minnion, Magdalena, Feelisch, Martin, Goor, Harry van, Sasser, Jennifer M, and Lely, A Titia

Published
2020

44. Conflicting Effects of Fetal Growth Restriction on Blood Pressure Between Human and Rat Offspring: A Meta-Analysis

Author

Arts-assistenten DV&B, MS Verloskunde, Circulatory Health, Brain, MS Nefrologie, Regenerative Medicine and Stem Cells, MMB opleiding Arts microbioloog, Child Health, Kooiman, Judith, Terstappen, Fieke, van Wagensveld, Lilian, Franx, Arie, Wever, Kimberley E, Roseboom, Tessa J, Joles, Jaap A, Gremmels, Hendrik, Lely, A Titia, Arts-assistenten DV&B, MS Verloskunde, Circulatory Health, Brain, MS Nefrologie, Regenerative Medicine and Stem Cells, MMB opleiding Arts microbioloog, Child Health, Kooiman, Judith, Terstappen, Fieke, van Wagensveld, Lilian, Franx, Arie, Wever, Kimberley E, Roseboom, Tessa J, Joles, Jaap A, Gremmels, Hendrik, and Lely, A Titia

Published
2020

45. Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats

Author

MS Verloskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Child Health, Terstappen, Fieke, Spradley, Frank T, Bakrania, Bhavisha A, Clarke, Sinéad M, Joles, Jaap A, Paauw, Nina D, Garrett, Michael R, Lely, A Titia, Sasser, Jennifer M, MS Verloskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Child Health, Terstappen, Fieke, Spradley, Frank T, Bakrania, Bhavisha A, Clarke, Sinéad M, Joles, Jaap A, Paauw, Nina D, Garrett, Michael R, Lely, A Titia, and Sasser, Jennifer M

Published
2019

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