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Your search keyword '"Terrier-Lacombe, Marie-José"' showing total 37 results
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37 results on '"Terrier-Lacombe, Marie-José"'

1. MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: A molecular portrait of stage 4S

Author

Bénard, Jean, Raguénez, Gilda, Kauffmann, Audrey, Valent, Alexander, Ripoche, Hugues, Joulin, Virginie, Job, Bastien, Danglot, Gisèle, Cantais, Sabrina, Robert, Thomas, Terrier-Lacombe, Marie-José, Chassevent, Agnès, Koscielny, Serge, Fischer, Matthias, Berthold, Frank, Lipinski, Marc, Tursz, Thomas, Dessen, Philippe, Lazar, Vladimir, and Valteau-Couanet, Dominique

Published
2008
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3. Impact of extensive surgery in multidisciplinary approach of pterygopalatine/infratemporal fossa soft tissue sarcoma

Author

Minard-Colin, Véronique, Kolb, Frédéric, Saint-Rose, Christian, Fayard, Florence, Janot, François, Rey, Annie, Canale, Sandra, Julieron, Morbize, Corradini, Nadège, Raquin, Marie-Anne, Habrand, Jean-Louis, Grill, Jacques, George, Bernard, Ba Huy, Patrice Tran, Couloignier, Vincent, Terrier-Lacombe, Marie-José, Luboinski, Bernard, Valteau-Couanet, Dominique, and Oberlin, Odile

Published
2013
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12. Epithelioid Sarcoma

Author

Chbani, Laila, primary, Guillou, Louis, additional, Terrier, Philippe, additional, Decouvelaere, Anne Valérie, additional, Grégoire, Fleur, additional, Terrier-Lacombe, Marie José, additional, Ranchère, Dominique, additional, Robin, Yves Marie, additional, Collin, Françoise, additional, Fréneaux, Paul, additional, and Coindre, Jean-Michel, additional

Published
2009
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13. Frequent EGFR Positivity and Overexpression in High-Grade Areas of Human MPNSTs

Author

Tabone-Eglinger, Séverine, primary, Bahleda, Radislav, additional, Côté, Jean-François, additional, Terrier, Philippe, additional, Vidaud, Dominique, additional, Cayre, Anne, additional, Beauchet, Alain, additional, Théou-Anton, Nathalie, additional, Terrier-Lacombe, Marie-José, additional, Lemoine, Antoinette, additional, Penault-Llorca, Frédérique, additional, Le Cesne, Axel, additional, and Emile, Jean-François, additional

Published
2008
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14. Translocation-positive Low-grade Fibromyxoid Sarcoma: Clinicopathologic and Molecular Analysis of a Series Expanding the Morphologic Spectrum and Suggesting Potential Relationship to Sclerosing Epithelioid Fibrosarcoma

Author

Guillou, Louis, primary, Benhattar, Jean, additional, Gengler, Carole, additional, Gallagher, Gabrielle, additional, Ranchère-Vince, Dominique, additional, Collin, Françoise, additional, Terrier, Philippe, additional, Terrier-Lacombe, Marie-José, additional, Leroux, Agnès, additional, Marquès, Bernard, additional, Aubain Somerhausen, Nicolas de Saint, additional, Keslair, Frédérique, additional, Pedeutour, Florence, additional, and Coindre, Jean-Michel, additional

Published
2007
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15. Rhabdomyosarcoma: Value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype

Author

Hostein, Isabelle, primary, Andraud-Fregeville, Marie, additional, Guillou, Louis, additional, Terrier-Lacombe, Marie-José, additional, Deminière, Colette, additional, Ranchère, Dominique, additional, Lussan, Catherine, additional, Longavenne, Elisabeth, additional, Bui, Nguyen Binh, additional, Delattre, Olivier, additional, and Coindre, Jean-Michel, additional

Published
2004
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18. ΔN-p73α Accumulates in Human Neuroblastic Tumors

Author

Douc-Rasy, Sétha, primary, Barrois, Michel, additional, Echeynne, Maria, additional, Kaghad, Mourad, additional, Blanc, Etienne, additional, Raguenez, Gilda, additional, Goldschneider, David, additional, Terrier-Lacombe, Marie-José, additional, Hartmann, Olivier, additional, Moll, Ute, additional, Caput, Daniel, additional, and Bénard, Jean, additional

Published
2002
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20. Overrepresentation of 7q31 and 17q in renal cell carcinomas

Author

Glukhova, Liubov, primary, Goguel, Anne-Françoise, additional, Chudoba, Ilse, additional, Angevin, Eric, additional, Pavon, Christine, additional, Terrier-Lacombe, Marie-José, additional, Meddeb, Mounira, additional, Escudier, Bernard, additional, and Bernheim, Alain, additional

Published
1998
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22. Potent therapeutic activity of irinotecan (CPT-11) and its schedule dependency in medulloblastoma xenografts in nude mice

Author

Vassal, Gilles, primary, Boland, Isabelle, additional, Santos, Alexandre, additional, Bissery, Marie-Christine, additional, Terrier-Lacombe, Marie-José, additional, Morizet, Jackie, additional, Sainte-Rose, Christian, additional, Lellouch-Tubiana, Arielle, additional, Kalifa, Chantal, additional, and Gouyette, Alain, additional

Published
1997
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23. Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma

Author

Simon, Marie-Pierre, primary, Pedeutour, Florence, additional, Sirvent, Nicolas, additional, Grosgeorge, Josiane, additional, Minoletti, Fabiola, additional, Coindre, Jean-Michel, additional, Terrier-Lacombe, Marie-José, additional, Mandahl, Nils, additional, Craver, Randall, additional, Blin, Nikolaus, additional, Sozzi, Gabriella, additional, Turc-Carel, Claude, additional, O'Brien, Kevin P., additional, Kedra, Darek, additional, Fransson, Ingegerd, additional, Guilbaud, Cécile, additional, and Dumanski, Jan P., additional

Published
1997
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27. Primitive malignant nonepithelial hepatic tumors in children

Author

Babin-Boilletot, Annie, primary, Flamant, Françoise, additional, Terrier-Lacombe, Marie-José, additional, Marsden, H. Basil, additional, van Unnik, Adriaan, additional, Deméocq, François, additional, Zucker, Jean-Michel, additional, Voúte, Paul A., additional, Otten, Jacques, additional, Behar, Catherine, additional, and Valayer, Jacques, additional

Published
1993
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30. MYCNgene overrepresentation detected in primary neuroblastoma tumour cells without amplification

Author

Valent, Alexander, Le Roux, Gwenaëlle, Barrois, Michel, Terrier‐Lacombe, Marie‐José, Valteau‐Couanet, Dominique, Léon, Bernadette, Spengler, Barbara, Lenoir, Gilbert, Bénard, Jean, and Bernheim, Alain

Abstract

Neuroblastoma is the most frequent solid extracranial neoplasm of childhood, with a median age of presentation of under 2 years. This tumour is highly malignant in patients older than 12 months of age with metastatic disease. Clinical studies have confirmed that amplification of the MYCNproto‐oncogene is one of the best prognostic indicators of poor outcome. Approximately 30% of neuroblastoma tumours present MYCNamplification at diagnosis. Far less is known about the incidence and consequences of overrepresentation of the gene due to duplication or rearrangement of the chromosome arm in which the gene is situated. This study has analysed 110 neuroblastomas by FISH and has detected a gain of 1–3 copies per cell of MYCNin 8% of MYCN‐non‐amplified tumours. In these primary tumours, cells gained small numbers of additional MYCNgenes by two mechanisms: formation of an isochromosome 2p, or an unbalanced translocation involving the short arm of chromosome 2 (with MYCN) and various partner chromosomes. Quantitative RT‐PCR showed three‐ to seven‐fold elevated MYCNexpression in three tumours. Although the follow‐up time to date is still short, clinical outcome suggests that low‐level overexpression of the MYCNgene does not enhance tumour aggressiveness and rapidity of disease progression, as is often seen in neuroblastoma with MYCNamplification. It is hypothesized that the small elevation in MYCNexpression could alter the regulation of apoptosis, as has been shown in experimental models. Copyright © 2002 John Wiley & Sons, Ltd.

Published
2002
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31. In VivoElimination of Acentric Double Minutes Containing Amplified MYCNfrom Neuroblastoma Tumor Cells Through the Formation of Micronuclei

Author

Valent, Alexander, Bénard, Jean, Clausse, Bernard, Barrois, Michel, Valteau-Couanet, Dominique, Terrier-Lacombe, Marie-José, Spengler, Barbara, and Bernheim, Alain

Abstract

Neuroblastoma, the most common solid extracranial neoplasm in children, shows an appreciable variability in clinical evolution. Amplification of the MYCNoncogene in this tumor is detected in 25 to 30% of cases and is associated with poor clinical outcome. In this study, quantitative polymerase chain reaction and fluorescence in situhybridization were used to determine MYCNamplification status in 46 neuroblastoma tumors. MYCNamplification was detected in tumors from 11 patients. Fluorescence in situhybridization revealed the presence of micronuclei containing amplified MYCNsequences in 8 of the 11 tumors. Micronuclei are indicative of spontaneous elimination or loss of amplified sequences by tumor cells. Because the elimination of amplified sequences can be enhanced in vitroby specific drugs such as hydroxyurea, our observations suggest a new therapeutic strategy specifically targeted to cells with amplified genes.

Published
2001
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34. [Localised rhabdomyosarcoma of the extremities in children and adolescents: results of the French experience].

Author

Diepold M, Rey A, Oberlin O, Boulay N, Bergeron C, Glorion C, Mary P, Terrier-Lacombe MJ, Helfre S, Habrand JL, Gentet JC, Defachelles AS, Thomas C, Brisse H, Pierron G, and Orbach D

Subjects
Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Child, Preschool, Combined Modality Therapy methods, France, Humans, Infant, Neoplasm Recurrence, Local, Prospective Studies, Second-Look Surgery, Treatment Outcome, Extremities, Rhabdomyosarcoma therapy
Abstract

Patients and Methods: Forty-six patients with localised RMS of the limbs entered the MMT 89 and 95 study in France. We studied potential risk factors that were predictive of relapse and survival to propose a therapeutic approach of surgery and radiotherapy appropriate to the risk of relapse., Results: Median age at diagnosis was 6.5 years [9 months to 15.5 years]. At time of diagnosis, 43% had marginal surgery and only 13% radical intervention. Primary re-excision was performed in 12% of the patients. All patients received chemotherapy, 43% had second look surgery and 37% received radiotherapy. Fifty-four percent of all tumors relapsed: local relapse 36%, nodes l8%, metastatic 40%, local and metastatic 16%. Estimated overall 5-year event-free survival (EFS) and overall survival (OS) were 40 and 57%, respectively., Conclusions: Prognosis of RMS of the limbs is bad but only 37% of the patients had radiotherapy. We could define patients with very high risk among those with limbs RMS as nodal involvement (5 years overall survival OS 22%), alveolar histology (OS 38%) and site of hand and foot (4 survivors out of 10 patients). In further studies, these patients should be treated even more aggressive with early surgery followed by re-excision if necessary, chemotherapy including alkylating agents and systematic radiotherapy.

Published
2008
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35. [Unusual urinary bladder polyps].

Author

Petitjean B, Nagorniewicz F, Locquet P, Terrier-Lacombe MJ, and Gaulard P

Subjects
Aged, Diagnosis, Differential, Female, Humans, Lymphoma, B-Cell, Marginal Zone pathology, Polyps surgery, Urinary Bladder pathology, Urinary Bladder Neoplasms surgery, Urothelium pathology, Polyps pathology, Urinary Bladder Neoplasms pathology
Published
2002

36. DeltaN-p73alpha accumulates in human neuroblastic tumors.

Author

Douc-Rasy S, Barrois M, Echeynne M, Kaghad M, Blanc E, Raguenez G, Goldschneider D, Terrier-Lacombe MJ, Hartmann O, Moll U, Caput D, and Bénard J

Subjects
Adrenal Medulla cytology, Adrenal Medulla metabolism, Cell Differentiation, Child, DNA-Binding Proteins genetics, Exons, Genes, Tumor Suppressor, Humans, Immunohistochemistry, Neoplasms, Nerve Tissue genetics, Neuroblastoma genetics, Nuclear Proteins genetics, Promoter Regions, Genetic, Protein Isoforms, Tumor Cells, Cultured, Tumor Protein p73, Tumor Suppressor Protein p53 metabolism, Tumor Suppressor Proteins, DNA-Binding Proteins metabolism, Neoplasms, Nerve Tissue metabolism, Neuroblastoma metabolism, Nuclear Proteins metabolism
Abstract

Neuroblastic tumors (NTs), occurring in early childhood, display a wide spectrum of differentiation. Recurrent deletions involving the p73 locus are frequently observed in undifferentiated NTs. To address the question of the possible implication of p73 in neuroblastic differentiation, we investigated the status of the expression of this gene in a panel of differentiated and undifferentiated tumors. Although mutations were not found, p73 transcript profiles differed between undifferentiated and differentiated tumors. The frequency of the transcripts lacking exon 2 (species 1-3) appeared to be higher in undifferentiated than in differentiating and differentiated NTs. In contrast, products from using an alternate promoter (DeltaN-p73) were present in all NTs. In addition, only DeltaN-p73, but not full-length proteins, were detected by immunoblotting, suggesting a greater stability of N-truncated isoforms. Importantly, as in the adrenal medulla, most NTs showed p73-positive immunohistological staining with a cellular distribution and intensity varying according to the neuronal differentiation. Surprisingly, we observed redistribution of p73 from the nucleus to the cytoplasm during neuroblastic differentiation. Our data suggest that, in undifferentiated NTs, a link may exist between the accumulation of DeltaN-p73alpha variants and the "nuclear exclusion" of p53.

Published
2002
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37. Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts.

Author

Geoerger B, Grill J, Opolon P, Morizet J, Aubert G, Terrier-Lacombe MJ, Bressac De-Paillerets B, Barrois M, Feunteun J, Kirn DH, and Vassal G

Subjects
Adenoviridae genetics, Animals, Cytopathogenic Effect, Viral, Female, Gene Deletion, Gene Expression Regulation, Neoplastic, Glioblastoma metabolism, Humans, Mice, Mice, Nude, Middle Aged, Receptors, Virus biosynthesis, Transcriptional Activation, Tumor Suppressor Protein p53 biosynthesis, Tumor Suppressor Protein p53 genetics, Virus Replication, Xenograft Model Antitumor Assays, Adenoviridae physiology, Adenovirus E1B Proteins genetics, Glioblastoma therapy, Glioblastoma virology, Tumor Suppressor Protein p53 physiology
Abstract

Treatment of malignant gliomas remains a major challenge in adults and children because of high treatment failure. The E1B 55 kDa-gene deleted adenovirus, ONYX-015 (ONYX Pharmaceuticals), was demonstrated to replicate selectively in and lyse tumor cells. Currently ongoing clinical trials of ONYX-015 in head and neck tumors are promising. Here, we demonstrate ONYX-015-mediated cell lysis and antitumor activity in three of four s.c. human malignant glioma xenografts deriving from primary tumors. Intratumoral injections of ONYX-015, 1 x 10(8) plaque-forming units daily for 5 consecutive days, yielded significant tumor growth delay in the p53 mutant xenografts IGRG88 and the p53 wild-type IGRG93 and IGRG121 treated at an advanced tumor stage. The p53 wild-type tumors IGRG93 and IGRG121 experienced 45% and 82% complete tumor regressions. Four and 8 of 11 animals, respectively, survived tumor free 4 months after treatment. Widespread intratumoral adenoviral replication was observed in tumor cells of these two xenografts compared with only scattered replication in the p53-mutant tumors. In addition to a fast tumor growth rate, wild-type p53 status was associated with increased antitumor activity of the E1B-attenuated virus, and induction of functional p53 may therefore determine adenoviral cytolysis in tumor cells. In conclusion, ONYX-015 displayed a major antitumor activity in human xenografts derived from primary malignant glioma supporting its development in the treatment of these highly malignant tumors.

Published
2002

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