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1. TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication

Author

Iachettini, Sara, Terrenato, Irene, Porru, Manuela, Di Vito, Serena, Rizzo, Angela, D’Angelo, Carmen, Petti, Eleonora, Dinami, Roberto, Maresca, Carmen, Di Benedetto, Anna, Palange, Aldo, Mulè, Antonino, Santoro, Angela, Palazzo, Antonella, Fuso, Paola, Stoppacciaro, Antonella, Vici, Patrizia, Filomeno, Lorena, Di Lisa, Francesca Sofia, Arcuri, Teresa, Krasniqi, Eriseld, Fabi, Alessandra, Biroccio, Annamaria, and Zizza, Pasquale

Published
2024
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2. Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim

Author

Marchesi, Francesco, Terrenato, Irene, Papa, Elena, Tomassi, Martina, Falcucci, Paolo, Gumenyuk, Svitlana, Palombi, Francesca, Pisani, Francesco, Renzi, Daniela, Romano, Atelda, Spadea, Antonio, Regazzo, Giulia, Rizzo, Maria Giulia, De Rienzo, Mafalda, Ripellino, Claudio, Sgromo, Simona, Viggiani, Caterina, Ponte, Eleonora, Kayal, Ramy, Cordone, Iole, Foddai, Maria Laura, and Mengarelli, Andrea

Published
2024
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5. Laparoscopic Compared with Open D2 Gastrectomy on Perioperative and Long-Term, Stage-Stratified Oncological Outcomes for Gastric Cancer: A Propensity Score-Matched Analysis of the IMIGASTRIC Database.

Author

Trastulli, Stefano, Desiderio, Jacopo, Lin, Jian-Xian, Reim, Daniel, Zheng, Chao-Hui, Borghi, Felice, Cianchi, Fabio, Norero, Enrique, Nguyen, Ninh T, Qi, Feng, Coratti, Andrea, Cesari, Maurizio, Bazzocchi, Francesca, Alimoglu, Orhan, Brower, Steven T, Pernazza, Graziano, D'Imporzano, Simone, Azagra, Juan-Santiago, Zhou, Yan-Bing, Cao, Shou-Gen, Garofoli, Eleonora, Mosillo, Claudia, Guerra, Francesco, Liu, Tong, Arcuri, Giacomo, González, Paulina, Staderini, Fabio, Marano, Alessandra, Terrenato, Irene, D'Andrea, Vito, Bracarda, Sergio, Huang, Chang-Ming, and Parisi, Amilcare

Subjects
gastric cancer, laparoscopy, minimally invasive surgery, Clinical Research, Patient Safety, Cancer, 6.4 Surgery, Oncology and Carcinogenesis
Abstract

BackgroundThe laparoscopic approach in gastric cancer surgery is being increasingly adopted worldwide. However, studies focusing specifically on laparoscopic gastrectomy with D2 lymphadenectomy are still lacking in the literature. This retrospective study aimed to compare the short-term and long-term outcomes of laparoscopic versus open gastrectomy with D2 lymphadenectomy for gastric cancer.MethodsThe protocol-based, international IMIGASTRIC (International study group on Minimally Invasive surgery for Gastric Cancer) registry was queried to retrieve data on patients undergoing laparoscopic or open gastrectomy with D2 lymphadenectomy for gastric cancer with curative intent from January 2000 to December 2014. Eleven predefined, demographical, clinical, and pathological variables were used to conduct a 1:1 propensity score matching (PSM) analysis to investigate intraoperative and recovery outcomes, complications, pathological findings, and survival data between the two groups. Predictive factors of long-term survival were also assessed.ResultsA total of 3033 patients from 14 participating institutions were selected from the IMIGASTRIC database. After 1:1 PSM, a total of 1248 patients, 624 in the laparoscopic group and 624 in the open group, were matched and included in the final analysis. The total operative time (median 180 versus 240 min, p < 0.0001) and the length of the postoperative hospital stay (median 10 versus 14.8 days, p < 0.0001) were longer in the open group than in the laparoscopic group. The conversion to open rate was 1.9%. The proportion of patients with in-hospital complications was higher in the open group (21.3% versus 15.1%, p = 0.004). The median number of harvested lymph nodes was higher in the laparoscopic approach (median 32 versus 28, p < 0.0001), and the proportion of positive resection margins was higher (p = 0.021) in the open group (5.9%) than in the laparoscopic group (3.2%). There was no significant difference between the groups in five-year overall survival rates (77.4% laparoscopic versus 75.2% open, p = 0.229).ConclusionThe adoption of the laparoscopic approach for gastric resection with D2 lymphadenectomy shortened the length of hospital stay and reduced postoperative complications with respect to the open approach. The five-year overall survival rate after laparoscopy was comparable to that for patients who underwent open D2 resection. The types of surgical approaches are not independent predictive factors for five-year overall survival.

Published
2021

8. Remote Assisted Home Dressing vs. Outpatient Medication of Central Venous Catheter (Peripherally Inserted Central Venous Catheter): Clinical Trial A.R.C.O. (Remote Assistance Oncology Caregiver)

Author

Basili, Paolo, primary, Farina, Ilaria, additional, Terrenato, Irene, additional, Centini, Jacopo, additional, Volpe, Nina, additional, Rizzo, Vanessa, additional, Agoglia, Laura, additional, Paterniani, Albina, additional, Aprea, Pasquale, additional, Calignano, Prisco, additional, Petrone, Fabrizio, additional, and Ciliberto, Gennaro, additional

Published
2024
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9. Correction to: Chronic Non-cancer Pain Management in a Tertiary Pain Clinic Network: a Retrospective Study

Author

Latina, Roberto, Varrassi, Giustino, Di Biagio, Ettore, Giannarelli, Diana, Gravante, Francesco, Paladini, Antonella, D’Angelo, Daniela, Iacorossi, Laura, Martella, Cristina, Alvaro, Rosaria, Ivziku, Dhurata, Veronese, Nicola, Barbagallo, Mario, Marchetti, Anna, Notaro, Paolo, Terrenato, Irene, Tarsitani, Gianfranco, and De Marinis, Maria Grazia

Published
2023
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10. Bridging therapeutic opportunities: a survey by the Italian molecular tumor board workgroup of Alliance Against Cancer

Author

Ciliberto, Gennaro, Canfora, Marco, Terrenato, Irene, Agnoletto, Chiara, Agustoni, Francesco, Amoroso, Loredana, Baldassarre, Gustavo, Curigliano, Giuseppe, Delmonte, Angelo, De Luca, Antonella, Fiorentino, Michelangelo, Gregorc, Vanesa, Ibrahim, Toni, Lazzari, Chiara, Mastronuzzi, Angela, Pronzato, Paolo, Santoro, Armando, Scambia, Giovanni, Tommasi, Stefania, Vingiani, Andrea, Giacomini, Patrizio, and De Maria, Ruggero

Published
2022
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12. SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma

Author

Loria, Rossella, Laquintana, Valentina, Scalera, Stefano, Fraioli, Rocco, Caprara, Valentina, Falcone, Italia, Bazzichetto, Chiara, Di Martile, Marta, Rosanò, Laura, Del Bufalo, Donatella, Bossi, Gianluca, Sperduti, Isabella, Terrenato, Irene, Visca, Paolo, Soddu, Silvia, Milella, Michele, Ciliberto, Gennaro, Falcioni, Rita, Ferraresi, Virginia, and Bon, Giulia

Published
2022
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13. Effect of Telenursing on Supportive Care Needs in Patients with Melanoma and Lung Cancer on Targeted Therapies: A Randomised Controlled Trial Study Protocol.

Author

De Leo, Aurora, Liquori, Gloria, Spano, Alessandro, Panattoni, Nicolò, Dionisi, Sara, Iacorossi, Laura, Giannetta, Noemi, Terrenato, Irene, Di Simone, Emanuele, Di Muzio, Marco, and Petrone, Fabrizio

Abstract

Background: Telenursing comprises a set of tools and interventions enabling nurses to provide remote care. This study aims to assess the impact of telenursing interventions on the supportive care needs of patients with melanoma and lung cancer who are receiving targeted therapies. Methods: This six-month monocentric, double-arm, randomised, controlled trial study protocol will assess the effect of telenursing on the supportive care needs (primary outcome) in 40 patients (20 in each group) after one month. The secondary outcomes will be monitored at baseline, one, three and six months: supportive care needs (at three and six months), therapeutic adherence, quality of life, usability and satisfaction, performance status, patient-reported outcomes and main adverse events. The SPIRIT guidelines will be used for the reporting. Results: The results from this trial will assess the impact of a telenursing intervention on cancer care. Conclusions: This trial could be a starting point for more extensive studies on telenursing interventions to promote nurses' skills, as well as the quality and safety of care in patients with cancer, highlighting the impact of more outstanding nursing contributions on cancer care. Trial and Protocol Registration: The study protocol was approved by the relevant Italian Ethics Committee Lazio Area 5 (RS1851/23, 2773; 6 September 2023) and was registered on ClinicalTrials.gov (trial registry number NCT06254196). [ABSTRACT FROM AUTHOR]

Published
2024
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14. Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI.

Author

Campo, Flaminia, Paolini, Francesca, Manciocco, Valentina, Moretto, Silvia, Pichi, Barbara, Moretti, Claudio, Blandino, Giovanni, De Pascale, Valentina, Benevolo, Maria, Pimpinelli, Fulvia, Vidiri, Antonello, Marzi, Simona, Ruggiero, Sergio, Terrenato, Irene, Iocca, Oreste, Venuti, Aldo, and Pellini, Raul

Subjects
HUMAN papillomavirus, HUMAN DNA, LYMPHATIC metastasis, OROPHARYNGEAL cancer, SQUAMOUS cell carcinoma
Abstract

Background: First aim was to compare ddPCR assays of ctHPVDNA with p16 IHC and qualitative HPV PCR. Second aim was to carry out longitudinal blood sampling to test for association of ctHPVDNA with histological confirmed recurrence. Third aim was to perform a multidimensional assessment which included: (1) clinical features; (2) ctHPVDNA; (3) MRI‐based tumor size measurements of primary tumor (PT) and cervical lymph node metastases (CLNM). Methods: Plasma samples were collected before treatment and during follow‐up, and ddPCR assay comprising E6 of HPV16 and HPV 33 and HPV 35 was used. Results: Present study was conducted at diagnosis in 117 patients and revealed a ctHPVDNA sensitivity of 100% (95% CI 95.5–100) and a specificity of 94.4 (95% CI 81.3–99.3), positive predictive value (PPV) of 94.4 (95% CI 81.3–99.3), and negative predictive value (NPP) of 100% (95% CI 89.7–100). During follow‐up ctHPVDNA had a sensitivity of 100% (95% CI 72.1–100)% and specificity of 98.4% (95% CI 91.7–100)%, PPV% of 90.9% (95% CI 62.3–98.4) and NPV% of 100% (95% CI 94.3–100) for ability to detect recurrence. Correlation between both the CLNM volume and the sum of PT and CLNM volume was observed. Conclusions: ctHPVDNA was superior to p16 in identification of HPV‐OPSCC at diagnosis. Introduction of ctHPVDNA, beyond diagnostic setting, represents a great opportunity to improve follow‐up protocol of OPSCC patients. [ABSTRACT FROM AUTHOR]

Published
2024
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15. hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.

Author

Di Modugno, Francesca, Spada, Sheila, Palermo, Belinda, Visca, Paolo, Iapicca, Pierluigi, Di Carlo, Anna, Antoniani, Barbara, Sperduti, Isabella, Di Benedetto, Anna, Terrenato, Irene, Mottolese, Marcella, Gandolfi, Francesco, Facciolo, Francesco, Chen, Emily I, Schwartz, Martin A, Santoni, Angela, Bissell, Mina J, and Nisticò, Paola

Subjects
Extracellular Matrix, Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Microfilament Proteins, Fibronectins, Protein Isoforms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, Integrin beta1, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Clinical Sciences
Abstract

We demonstrated previously that the splicing of the actin regulator, hMENA, generates two alternatively expressed isoforms, hMENA11a and hMENAΔv6, which have opposite functions in cell invasiveness. Their mechanisms of action have remained unclear. Here we report two major findings: (i) hMENA regulates β1 integrin expression. This was shown by depleting total hMENA, which led to loss of nuclear expression of serum response factor (SRF)-coactivator myocardin-related transcription factor 1 (MRTF-A), leading to an increase in the G-actin/F-actin ratio crucial for MRTF-A localization. This in turn inhibited SRF activity and the expression of its target gene β1 integrin. (ii) hMENA11a reduces and hMENAΔv6 increases β1 integrin activation and signaling. Moreover, exogenous expression of hMENA11a in hMENAΔv6-positive cancer cells dramatically reduces secretion of extracellular matrix (ECM) components, including β1 integrin ligands and metalloproteinases. On the other hand, overexpression of the pro-invasive hMENAΔv6 increases fibronectin production. In primary tumors high hMENA11a correlates with low stromal fibronectin and a favorable clinical outcome of early node-negative non-small-cell lung cancer patients. These data provide new insights into the roles of hMENA11a and hMENAΔv6 in the druggable β1 integrin-ECM signaling axis and allow stratification of patient risk, guiding their clinical management.

Published
2018

16. KEAP1 and TP53 Frame Genomic, Evolutionary, and Immunologic Subtypes of Lung Adenocarcinoma With Different Sensitivity to Immunotherapy

Author

Scalera, Stefano, Mazzotta, Marco, Corleone, Giacomo, Sperati, Francesca, Terrenato, Irene, Krasniqi, Eriseld, Pizzuti, Laura, Barba, Maddalena, Vici, Patrizia, Gallo, Enzo, Buglioni, Simonetta, Visca, Paolo, Pescarmona, Edoardo, Marinelli, Daniele, De Nicola, Francesca, Ciuffreda, Ludovica, Goeman, Frauke, Fanciulli, Maurizio, Giusti, Raffaele, Vecchione, Andrea, De Maria, Ruggero, Cappuzzo, Federico, Marchetti, Paolo, Ciliberto, Gennaro, and Maugeri-Saccà, Marcello

Published
2021
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17. A real-world multicentre evaluation of atezolizumab plus platinum-etoposide chemotherapy as first-line treatment in patients with extensive-stage small cell lung cancer in Italy

Author

Musicco, Felice, primary, Fulgenzio, Chiara, additional, Malfa, Antonia La, additional, Jannitti, Nicoletta, additional, Vitiello, Antonietta, additional, Carpano, Silvia, additional, Fusco, Francesca, additional, Cappuzzo, Federico, additional, Terrenato, Irene, additional, Sperduti, Isabella, additional, Polidori, Piera, additional, Tarantino, Domenico, additional, Cerbo, Lidia Di, additional, Pani, Marcello, additional, Isgrò, Valentina, additional, and Lasala, Ruggero, additional

Published
2024
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19. p53 and BLC2 Immunohistochemical Expression Across Molecular Subtypes in 1099 Early Breast Cancer Patients With Long-Term Follow-up: An Observational Study

Author

Fabi, Alessandra, Mottolese, Marcella, Di Benedetto, Anna, Sperati, Francesca, Ercolani, Cristiana, Buglioni, Simonetta, Nisticò, Cecilia, Ferretti, Gianluigi, Vici, Patrizia, Perracchio, Letizia, Malaguti, Paola, Russillo, Michelangelo, Botti, Claudio, Pescarmona, Edoardo, Cognetti, Francesco, and Terrenato, Irene

Published
2020
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20. Second surgery for relapsed glioblastoma: an observational study on criteria for patient selection in real life.

Author

Lecce, Mario, Rasile, Fabrizio, Tanzilli, Antonio, Gaviani, Paola, Mariantonia, Carosi, Villani, Veronica, Pace, Andrea, Terrenato, Irene, Casini, Beatrice, Novello, Mariangela, and Telera, Stefano

Abstract

Aim: There is little consensus on salvage management of glioblastoma after recurrence, for lack of evidence. Materials & methods: A retrospective study of treatments in patients with recurrent glioblastoma. Results: Surgery at recurrence was related to better overall survival (OS) and progression-free survival (PFS). Surgery at recurrence, Karnofsky index, MGMT methylation status, younger age at diagnosis and number of chemotherapy cycles were positive factors for OS and PFS. The benefit of OS was relevant for a second surgery performed at least 9 months after the first one. Systemic treatments after the second surgery were linked to an improved PFS. Conclusion: Younger age, Karnofsky index, MGMT methylation status and a median time between surgeries ≥9 months may be criteria for eligibility for surgery at recurrence. Article highlights Therapeutic options for the recurrence of glioblastoma are scarce. There are no shared recommendations for the treatment of recurrent glioblastoma. We made a retrospective study on patients with recurrent glioblastoma, comparing those who had a second surgery vs those who had other treatments. Second surgery was related to better overall survival (OS) and progression-free survival (PFS). Second surgery, Karnofsky index, MGMT methylation status, younger age at diagnosis and number of chemotherapy cycles were positive factors for OS and PFS. The benefit of OS was relevant for a second surgery performed at least 9 months after the first one. Systemic treatments after the second surgery were linked to an improved PFS. Second surgery is the first-line intervention choice at recurrence in a selected subset of patients. The surgery option should be part of a multidisciplinary diagnostic and therapeutic pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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21. DNA Damage Response in Early Breast Cancer: A Phase III Cohort in the Phobos Study.

Author

Krasniqi, Eriseld, Ercolani, Cristiana, Di Benedetto, Anna, Di Lisa, Francesca Sofia, Filomeno, Lorena, Arcuri, Teresa, Botti, Claudio, Pelle, Fabio, Cavicchi, Flavia, Cappelli, Sonia, Barba, Maddalena, Pizzuti, Laura, Maugeri-Saccà, Marcello, Moscetti, Luca, Grassadonia, Antonino, Tinari, Nicola, Sanguineti, Giuseppe, Takanen, Silvia, Fragnito, Davide, and Terrenato, Irene

Subjects
BREAST tumor treatment, LYMPH nodes, DOCETAXEL, RESEARCH funding, EARLY detection of cancer, HYDROCARBONS, DNA, TUMOR markers, CELLULAR signal transduction, ATAXIA telangiectasia, LONGITUDINAL method, IMMUNOHISTOCHEMISTRY, GENE expression, PHOSPHOPROTEINS, CYCLOPHOSPHAMIDE
Abstract

Simple Summary: This study evaluates DDR biomarkers in 222 node-positive early breast cancer patients from a Phase III trial on adjuvant taxanes. Over a 234-month follow-up period, no differences in DFS or OS were observed between treatment groups. However, a DDR risk score, influenced by ATM and ATR expression, proved to be an independent prognostic factor for both DFS and OS. Validation in a public cohort confirmed ATM's protective role. These findings highlight the importance of DDR pathways in breast cancer prognostication and support, integrating molecular markers with clinical–pathological factors to inform treatment strategies. We assessed the impact of DNA damage response and repair (DDR) biomarker expressions in 222 node-positive early breast cancer (BC) patients from a previous Phase III GOIM 9902 trial of adjuvant taxanes. At a median follow-up of 64 months, the original study showed no disease-free survival (DFS) or overall survival (OS) differences with the addition of docetaxel (D) to epirubicine-cyclophosphamide (EC). Immunohistochemistry was employed to assess the expression of DDR phosphoproteins (pATM, pATR, pCHK1, γH2AX, pRPA32, and pWEE1) in tumor tissue, and their association with clinical outcomes was evaluated through the Cox elastic net model. Over an extended follow-up of 234 months, we confirmed no significant differences in DFS or OS between patients treated with EC and those receiving D → EC. A DDR risk score, inversely driven by ATM and ATR expression, emerged as an independent prognostic factor for both DFS (HR = 0.41, p < 0.0001) and OS (HR = 0.61, p = 0.046). Further validation in a public adjuvant BC cohort was possible only for ATM, confirming its protective role. Overall, our findings confirm the potential role of the DDR pathway in BC prognostication and in shaping treatment strategies advocating for an integrated approach, combining molecular markers with clinical–pathological factors. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Global variation in the long-term outcomes of ypT0 rectal cancers

Author

Terrenato, Irene, Shinde, Rajesh S., Saklani, Avanish, Martins, Pedro, Videira, José Flávio, Bonci, Eduard-Alexandru, Achimas-Cadariu, Patriciu, Marinello, Franco, Espin, Eloy, Xenaki, Sofia, Lasithiotakis, Konstantinos, Rega, Daniela, Delrio, Paolo, Andrási, László, Lázár, György, Quattromani, Roberto, Elmore, Ugo, Branciforte, Martina Azzurra, Piazza, Diego, Sztipits, Tamás, Mersich, Tamás, Vigorita, Vincenzo, Ildefonso, Alberto San, Cianflocca, Desiree, Giuffrida, Maria Carmela, Biondi, Alberto, Persiani, Roberto, Košir, Jurij Aleš, Grosek, Jan, Rizzo, Gianluca, Coco, Claudio, Dieninyte-Misiune, Egle, Bausys, Rimantas, Bausys, Augustinas, Poskus, Tomas, Dupré, Aurélien, Muresan, Mihai-Stefan, Ionescu, Călin, Alyami, Mohammad, Cotte, Eddy, Candido, Francesca Di, Spinelli, Antonino, Lucarini, Alessio, Balducci, Genoveffa, Kisielewski, Michał, Pędziwiatr, Michał, Kroon, Hidde, Sammour, Tarik, Unger, Lukas, Stift, Anton, Marsanic, Patrizia, Muratore, Andrea, Uzunoglu, Mustafa Yener, Altintoprak, Fatih, Capponi, Michela Giulii, Poiasina, Elia, Brandl, Andreas, Aigner, Felix, Aparício, David, Leichsenring, Carlos, Corleone, Pio, Manzini, Nicolò de, Kabata, Paweł, Świerblewski, Maciej, Gallo, Gaetano, Trompetto, Mario, Negoi, Ionut, Beuran, Mircea, Souriti, Ahmad, Taylor, Gregory, De Luca, Raffaele, Simone, Michele, Bedford, Matthew, Charalampakis, Vasileios, Rajan, Shiv, Chaturvedi, Arun, Veltri, Marco, Parini, Dario, Turati, Luca, Sgroi, Giovanni, Bratu, Matei, Diaconescu, Bogdan, Slavchev, Mihail, Belev, Nikolay, Perfumo, Mariana Matzner, Rotholtz, Nicolas, Wajda, Justyna, Wysocki, Wojciech, Fernandez, Carmen Cagigas, Ruiz, Marcos Gomez, Marino, Serafino, Resta, Giuseppe, Ivanov, Tsvetomir, Dimitrov, Dobromir, Kaufmann, Claudia, Kafka-Ritsch, Reinhold, Yalkin, Omer, Ünal, Ali Ekrem, Loche, Giovanni Augusto, Cillara, Nicola, Colombo, Francesco, Foschi, Diego, Pollesel, Sara, Roviello, Franco, Lorenzon, Laura, Evrard, Serge, Beets, Geerard, Gonzalez-Moreno, Santiago, Kovacs, Tibor, D’Ugo, Domenico, and Polom, Karol

Published
2020
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25. Dynamics of humoral and cellular response to three doses of anti-SARS-CoV-2 BNT162b2 vaccine in patients with hematological malignancies and older subjects

Author

Laquintana, Valentina, primary, Mottini, Carla, additional, Marchesi, Francesco, additional, Marcozzi, Benedetta, additional, Terrenato, Irene, additional, Sperandio, Eleonora, additional, de Latouliere, Luisa, additional, Carrieri, Francesca, additional, Pimpinelli, Fulvia, additional, Pontone, Martina, additional, Pellini, Raul, additional, Campo, Flaminia, additional, Conti, Laura, additional, Accetta, Celeste, additional, Mandoj, Chiara, additional, Petrone, Fabrizio, additional, Di Bella, Ornella, additional, Vujovic, Branka, additional, Morrone, Aldo, additional, Compagnone, Mirco, additional, Principato, Eugenia, additional, Pinto, Eleonora, additional, Papa, Elena, additional, Falcucci, Paolo, additional, La Malfa, Antonia, additional, Pallocca, Matteo, additional, De Marco, Federico, additional, Piaggio, Giulia, additional, Ciliberto, Gennaro, additional, Mengarelli, Andrea, additional, and di Martino, Simona, additional

Published
2024
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26. Narrative Medicine: A Digital Diary in the Management of Patients with Bone and Soft Tissue Sarcoma—A Multidisciplinary Pilot Study

Author

Cercato, Maria Cecilia, primary, Onesti, Concetta Elisa, additional, Vari, Sabrina, additional, Maggi, Gabriella, additional, Faltyn, Wioletta, additional, Ceddia, Serena, additional, Terrenato, Irene, additional, Scarinci, Virginia, additional, Servoli, Francesca, additional, Cenci, Cristina, additional, Biagini, Roberto, additional, and Ferraresi, Virginia, additional

Published
2023
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27. Transcriptional phenocopies of deleterious KEAP1 mutations dictate survival outcomes in lung cancer treated with immunotherapy.

Author

Scalera, Stefano, primary, Ricciuti, Biagio, additional, Marinelli, Daniele, additional, Mazzotta, Marco, additional, Cipriani, Laura, additional, Bon, Giulia, additional, Schiavoni, Giulia, additional, Terrenato, Irene, additional, Di Federico, Alessandro, additional, Alessi, Joao, additional, Fanciulli, Maurizio, additional, Ciuffreda, Ludovica, additional, De Nicola, Francesca, additional, Goeman, Frauke, additional, Caravagna, Giulio, additional, Santini, Daniele, additional, De Maria, Ruggero, additional, Cappuzzo, Federico, additional, Ciliberto, Gennaro, additional, Jamal-Hanjani, Mariam, additional, Awad, Mark, additional, McGranahan, Nicholas, additional, and Maugeri-Saccà, Marcello, additional

Published
2023
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29. P487: MIDOSTAURIN PLASMA EXPOSURE IN PATIENTS WITH FLT3-MUT ACUTE MYELOID LEUKEMIA UNDERGOING POSACONAZOLE PROPHYLAXIS DURING INDUCTION TREATMENT: A PROSPECTIVE MULTICENTRE STUDY FROM THE SEIFEM GROUP

Author

Marchesi, Francesco, primary, Menna, Pierantonio, additional, Cattaneo, Chiara, additional, Candoni, Anna, additional, Delia, Mario, additional, Nadali, Gianpaolo, additional, Pasciolla, Crescenza, additional, Perrone, Salvatore, additional, Verga, Luisa, additional, Armiento, Daniele, additional, Ilaria DEL Principe, Maria, additional, Stefano Fracchiolla, Nicola, additional, Salvatorelli, Emanuela, additional, Lupisella, S, additional, Terrenato, Irene, additional, Busca, Alessandro, additional, and Pagano, Livio, additional

Published
2023
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30. Posaconazole and midostaurin in patients with FLT3‐mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study

Author

Menna, Pierantonio, primary, Marchesi, Francesco, additional, Cattaneo, Chiara, additional, Candoni, Anna, additional, Delia, Mario, additional, Nadali, Gianpaolo, additional, Vatteroni, Alessandra, additional, Pasciolla, Crescenza, additional, Perrone, Salvatore, additional, Verga, Luisa, additional, Armiento, Daniele, additional, Del Principe, Maria Ilaria, additional, Fracchiolla, Nicola S., additional, Salvatorelli, Emanuela, additional, Lupisella, Santina, additional, Terrenato, Irene, additional, Busca, Alessandro, additional, Minotti, Giorgio, additional, and Pagano, Livio, additional

Published
2023
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31. Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in “Real-Life”: The SEIFEM Experience

Author

Fianchi, Luana, primary, Guolo, Fabio, additional, Marchesi, Francesco, additional, Cattaneo, Chiara, additional, Gottardi, Michele, additional, Restuccia, Francesco, additional, Candoni, Anna, additional, Ortu La Barbera, Elettra, additional, Fazzi, Rita, additional, Pasciolla, Crescenza, additional, Finizio, Olimpia, additional, Fracchiolla, Nicola, additional, Delia, Mario, additional, Lessi, Federica, additional, Dargenio, Michelina, additional, Bonuomo, Valentina, additional, Del Principe, Maria Ilaria, additional, Zappasodi, Patrizia, additional, Picardi, Marco, additional, Basilico, Claudia, additional, Piedimonte, Monica, additional, Minetto, Paola, additional, Giordano, Antonio, additional, Chiusolo, Patrizia, additional, Prezioso, Lucia, additional, Buquicchio, Caterina, additional, Melillo, Lorella Maria Antonia, additional, Zama, Daniele, additional, Farina, Francesca, additional, Mancini, Valentina, additional, Terrenato, Irene, additional, Rondoni, Michela, additional, Urbino, Irene, additional, Tumbarello, Mario, additional, Busca, Alessandro, additional, and Pagano, Livio, additional

Published
2023
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36. Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in 'Real-Life': The SEIFEM Experience

Author

Fianchi, Luana, Guolo, Fabio, Marchesi, Francesco, Cattaneo, Chiara, Gottardi, Michele, Restuccia, Francesco, Candoni, Anna, Ortu La Barbera, Elettra, Fazzi, Rita, Pasciolla, Crescenza, Finizio, Olimpia, Fracchiolla, Nicola, Delia, Mario, Lessi, Federica, Dargenio, Michelina, Bonuomo, Valentina, Del Principe, Maria Ilaria, Zappasodi, Patrizia, Picardi, Marco, Basilico, Claudia, Piedimonte, Monica, Minetto, Paola, Giordano, Antonio, Chiusolo, Patrizia, Prezioso, Lucia, Buquicchio, Caterina, Melillo, Lorella Maria Antonia, Zama, Daniele, Farina, Francesca, Mancini, Valentina, Terrenato, Irene, Rondoni, Michela, Urbino, Irene, Tumbarello, Mario, Busca, Alessandro, and Pagano, Livio

Subjects
febrile events, CPX-351 therapy, secondary acute myeloid leukemia
Published
2023

38. Chronic Non-cancer Pain Management in a Tertiary Pain Clinic Network: a Retrospective Study

Author

Latina, Roberto, primary, Varrassi, Giustino, additional, Di Biagio, Ettore, additional, Giannarelli, Diana, additional, Gravante, Francesco, additional, Paladini, Antonella, additional, D’Angelo, Daniela, additional, Iacorossi, Laura, additional, Martella, Cristina, additional, Alvaro, Rosaria, additional, Ivziku, Dhurata, additional, Veronese, Nicola, additional, Barbagallo, Mario, additional, Marchetti, Anna, additional, Notaro, Paolo, additional, Terrenato, Irene, additional, Tarsitani, Gianfranco, additional, and De Marinis, Maria Grazia, additional

Published
2022
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39. 2022-RA-295-ESGO Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer

Author

Ronchetti, Livia, primary, Terrenato, Irene, additional, Ferretti, Margherita, additional, Corrado, Giacomo, additional, Goeman, Frauke, additional, Donzelli, Sara, additional, Mandoj, Chiara, additional, Merola, Roberta, additional, Zampa, Ashanti, additional, Carosi, Mariantonia, additional, Blandino, Giovanni, additional, Conti, Laura, additional, Lobascio, Anna Maria, additional, Iacobelli, Marcello, additional, Vizza, Enrico, additional, Piaggio, Giulia, additional, and Gurtner, Aymone, additional

Published
2022
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41. Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer

Author

Pallocca, Matteo, Goeman, Frauke, De Nicola, Francesca, Melucci, Elisa, Sperati, Francesca, Terrenato, Irene, Pizzuti, Laura, Casini, Beatrice, Gallo, Enzo, Amoreo, Carla Azzurra, Vici, Patrizia, Di Lauro, Luigi, Buglioni, Simonetta, Diodoro, Maria Grazia, Pescarmona, Edoardo, Mazzotta, Marco, Barba, Maddalena, Fanciulli, Maurizio, De Maria, Ruggero, Ciliberto, Gennaro, and Maugeri-Saccà, Marcello

Published
2018
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43. Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: an explorative pilot study

Author

Marchesi, Francesco, Regazzo, Giulia, Palombi, Francesca, Terrenato, Irene, Sacconi, Andrea, Spagnuolo, Manuela, Donzelli, Sara, Marino, Mirella, Ercolani, Cristiana, Di Benedetto, Anna, Blandino, Giovanni, Ciliberto, Gennaro, Mengarelli, Andrea, and Rizzo, Maria Giulia

Published
2018
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45. A Real-World Systematic Analysis of Driver Mutations’ Prevalence in Early- and Advanced-Stage NSCLC: Implications for Targeted Therapies in the Adjuvant Setting

Author

Terrenato, Irene, primary, Ercolani, Cristiana, additional, Di Benedetto, Anna, additional, Gallo, Enzo, additional, Melucci, Elisa, additional, Casini, Beatrice, additional, Rollo, Francesca, additional, Palange, Aldo, additional, Visca, Paolo, additional, Pescarmona, Edoardo, additional, Melis, Enrico, additional, Gallina, Filippo, additional, Sacconi, Andrea, additional, Cecere, Fabiana Letizia, additional, Landi, Lorenza, additional, Cappuzzo, Federico, additional, Ciliberto, Gennaro, additional, and Buglioni, Simonetta, additional

Published
2022
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49. High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study

Author

Cattaneo, Chiara, primary, Marchesi, Francesco, additional, Terrenato, Irene, additional, Bonuomo, Valentina, additional, Fracchiolla, Nicola Stefano, additional, Delia, Mario, additional, Criscuolo, Marianna, additional, Candoni, Anna, additional, Prezioso, Lucia, additional, Facchinelli, Davide, additional, Pasciolla, Crescenza, additional, Del Principe, Maria Ilaria, additional, Dargenio, Michelina, additional, Buquicchio, Caterina, additional, Mitra, Maria Enza, additional, Farina, Francesca, additional, Borlenghi, Erika, additional, Nadali, Gianpaolo, additional, Gagliardi, Vito Pier, additional, Fianchi, Luana, additional, Sciumè, Mariarita, additional, Menna, Pierantonio, additional, Busca, Alessandro, additional, Rossi, Giuseppe, additional, and Pagano, Livio, additional

Published
2022
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50. Diagnostic Accuracy of Contrast-Enhanced, Spectral Mammography (CESM) and 3T Magnetic Resonance Compared to Full-Field Digital Mammography plus Ultrasound in Breast Lesions: Results of a (Pilot) Open-Label, Single-Centre Prospective Study

Author

Ferranti, Francesca Romana, primary, Vasselli, Federica, additional, Barba, Maddalena, additional, Sperati, Francesca, additional, Terrenato, Irene, additional, Graziano, Franco, additional, Vici, Patrizia, additional, Botti, Claudio, additional, and Vidiri, Antonello, additional

Published
2022
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