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1. Are we ready for a National Forest Information System? State of the art of forest maps and airborne laser scanning data availability in Italy

Author

D’Amico G, Vangi E, Francini S, Giannetti F, Nicolaci A, Travaglini D, Massai L, Giambastiani Y, Terranova C, and Chirici G

Subjects
National Datasets, Forest Inventory, Forest Monitoring, Forest Mask, Airborne Laser Scanning, LiDAR, Forestry, SD1-669.5
Abstract

Forest planning, forest management, and forest policy require updated, reliable, and harmonized spatial datasets. In Italy a national geographic Forest Information System (FIS) designed to store and facilitate the access and analysis of spatial datasets is still missing. Among the different information layers which are useful to start populating a FIS, two are essential for their multiple use in the assessment of forest resources: (i) forest mapping, and (ii) data from Airborne Laser Scanning (ALS). Both layers are not available wall-to-wall for Italy, though different local sources of information potentially useful for their implementation already exist. The objectives of this work were to: (i) review forest maps and ALS data availability in Italy; (ii) develop for the first time a high resolution forest mask of Italy which was validated against the official statistics of the Italian National Forest Inventory; (iii) develop the first mosaic of all the main ALS data available in Italy producing a consistent Canopy Height Model (CHM). An on-line geographic FIS with free access to both layers from (ii) and (iii) was developed for demonstration purposes. The total area of forest and other wooded lands computed from the forest mask was 102.608.82 km2 (34% of the Italian territory), i.e., 1.9% less than the NFI benchmark estimate. This map is currently the best wall-to-wall forest mask available for Italy. We showed that only the 63% of the Italian territory (the 60% of the forest area) is covered by ALS data. These results highlight the urgent need for a national strategy to complete the availability of forest data in Italy.

Published
2021
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15. IceCube Collaboration Contributions to the 2009 International Cosmic Ray Conference

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J. A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S. W., Bay, R., Alba, J. L. Bazo, Beattie, K., Beatty, J. J., Bechet, S., Becker, J. K., Becker, K. -H., Benabderrahmane, M. L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D. Z., Bissok, M., Blaufuss, E., Boersma, D. J., Bohm, C., Bolmont, J., Botner, O., Bradley, L., Braun, J., Breder, D., Carson, M., Castermans, T., Chirkin, D., Christy, B., Clem, J., Cohen, S., Cowen, D. F., D'Agostino, M. V., Danninger, M., Day, C. T., De Clercq, C., Demiroers, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Di-az-Velez, J. C., Dreyer, J., Dumm, J. P., Duvoort, M. R., Edwards, W. R., Ehrlich, R., Eisch, J., Ellsworth, R. W., Engdegard, O., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Feusels, T., Filimonov, K., Finley, C., Foerster, M. M., Fox, B. D., Franckowiak, A., Franke, R., Gaisser, T. K., Gallagher, J., Ganugapati, R., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J. A., Gozzini, R., Grant, D., Griesel, T., Gross, A., Grullon, S., Gunasingha, R. M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Helbing, K., Herquet, P., Hickford, S., Hill, G. C., Hoffman, K. D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hulss, J. -P., Hulth, P. O., Hultqvist, K., Hussain, S., Imlay, R. L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G. S., Johansson, H., Joseph, J. M., Kampert, K. -H., Kappes, A., Karg, T., Karle, A., Kelley, J. L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Klein, S. R., Knops, S., Kohnen, G., Kolanoski, H., Koepke, L., Koskinen, D. J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Lehmann, R., Lennarz, D., Lucke, A., Luenemann, J., Lundberg, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H. S., McParland, C. P., Meagher, K., Merck, M., Meszaros, P., Meures, T., Middell, E., Milke, N., Miyamoto, H., Montaruli, T., Morse, R., Movit, S. M., Nahnhauer, R., Nam, J. W., Niessen, P., Nygren, D. R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Patton, S., Paul, L., Heros, C. Perez de los, Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A. C., Porrata, R., Potthoff, N., Price, P. B., Prikockis, M., Przybylski, G. T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J. P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H. -G., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S. H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R. G., Stoufer, M. C., Stoyanov, S., Strahler, E. A., Straszheim, T., Sulanke, K. -H., Sullivan, G. W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Toale, P. A., Tooker, J., Tosi, D., Turcan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wiedemann, A., Wikstrom, G., Williams, D. R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X. W., Yodh, G., and Yoshida, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Nuclear Experiment
Abstract

IceCube Collaboration Contributions to the 2009 International Cosmic Ray Conference, Comment: Index file for IceCube contributions to the 2009 ICRC; corrected author list

Published
2010

16. Calibration and Characterization of the IceCube Photomultiplier Tube

Author

The IceCube Collaboration, Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J. A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S. W., Bay, R., Alba, J. L. Bazo, Beattie, K., Beatty, J. J., Bechet, S., Becker, J. K., Becker, K. -H., Benabderrahmane, M. L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D. Z., Bissok, M., Blaufuss, E., Boersma, D. J., Bohm, C., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Cohen, S., Colnard, C., Cowen, D. F., D'Agostino, M. V., Danninger, M., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J. C., Dreyer, J., Dumm, J. P., Duvoort, M. R., Ehrlich, R., Eisch, J., Ellsworth, R. W., Engdegård, O., Euler, S., Evenson, P. A., Fadiran, O., Fazely, A. R., Feusels, T., Filimonov, K., Finley, C., Foerster, M. M., Fox, B. D., Franckowiak, A., Franke, R., Gaisser, T. K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J. A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R. M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Haugen, J., Helbing, K., Herquet, P., Hickford, S., Hill, G. C., Hoffman, K. D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J. -P., Hulth, P. O., Hultqvist, K., Hussain, S., Imlay, R. L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G. S., Johansson, H., Joseph, J. M., Kampert, K. -H., Kappes, A., Karg, T., Karle, A., Kelley, J. L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Kitamura, N., Klein, S. R., Knops, S., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D. J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Laundrie, A., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H. S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Miyamoto, H., Montaruli, T., Morse, R., Movit, S. M., Nahnhauer, R., Nam, J. W., Naumann, U., Nießen, P., Nygren, D. R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Heros, C. Pérez de los, Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A. C., Porrata, R., Posselt, J., Price, P. B., Prikockis, M., Przybylski, G. T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robl, P., Rodrigues, J. P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H. -G., Sandstrom, P., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S. H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R. G., Stoyanov, S., Strahler, E. A., Straszheim, T., Sullivan, G. W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Toale, P. A., Tosi, D., Turcan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Wahl, D., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wikström, G., Williams, D. R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X. W., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Over 5,000 PMTs are being deployed at the South Pole to compose the IceCube neutrino observatory. Many are placed deep in the ice to detect Cherenkov light emitted by the products of high-energy neutrino interactions, and others are frozen into tanks on the surface to detect particles from atmospheric cosmic ray showers. IceCube is using the 10-inch diameter R7081-02 made by Hamamatsu Photonics. This paper describes the laboratory characterization and calibration of these PMTs before deployment. PMTs were illuminated with pulses ranging from single photons to saturation level. Parameterizations are given for the single photoelectron charge spectrum and the saturation behavior. Time resolution, late pulses and afterpulses are characterized. Because the PMTs are relatively large, the cathode sensitivity uniformity was measured. The absolute photon detection efficiency was calibrated using Rayleigh-scattered photons from a nitrogen laser. Measured characteristics are discussed in the context of their relevance to IceCube event reconstruction and simulation efforts., Comment: 40 pages, 12 figures

Published
2010
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17. The endogenous oxytocin after manipulative osteopathic treatment in full-term pregnant women.

Author

RAGUSA, A., SVELATO, A., FOGOLARI, M., FICAROLA, F., PLOTTI, F., DE LUCA, C., D'AVINO, S., DAVINI, F., DE CESARIS, M., MESSINA, G., BERTOLINI, A., MARCI, R., ANGELETTI, S., ANGIOLI, R., and TERRANOVA, C.

Abstract

OBJECTIVE: The aim of this study is to assess whether the touch of osteopathic manipulative treatment (OMT) can affect the endogenous production of oxytocin in fullterm pregnant women and the assessment of well-being following the treatment. PATIENTS AND METHODS: In this study have been enrolled 57 pregnant women at full-term pregnancy (37th-41st week) for evaluation of the concentration of salivary oxytocin 2 minutes before and 2 minutes after a single session of OMT by an osteopath lasting for 30 minutes. Pre-OMT and post-OMT saliva samples were collected with the use of Salivette® salivary swabs. 7 salivary swabs were excluded from the analysis. 50 samples were analyzed with an appropriate ELISA kit. RESULTS: The mean OT salivary concentration pre-OMT was 89.98±16.39, and post-OMT was 100.60±19.13 tends to increase with p=0.0000051. In multivariate analysis, two subgroups show interesting data in the mean difference in OT salivary concentration post-OMT: women with painful contractions (p=0.06) and women under 35 years (p=0.09). CONCLUSIONS: The results of this study demonstrate that the effectiveness of OMT-increasing endogenous oxytocin is statistically significant in full-term pregnant women. The sensation of well-being found in most women indicates that there has been a predominantly central rather than peripheral oxytocin release after OMT. [ABSTRACT FROM AUTHOR]

Published
2024

20. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro R, Pilotto A, Esposito M, Olivola E, Nicoletti A, Lazzeri G, Magistrelli L, Dallocchio C, Marchese R, Bologna M, Tessitore A, Misceo S, Gigante AF, Terranova C, Moschella V, di Biase L, Di Giacopo R, Morgante F, Valentino F, De Rosa A, Trinchillo A, Malaguti MC, Brusa L, Matinella A, Di Biasio F, Paparella G, De Micco R, Contaldi E, Modugno N, Di Fonzo A, Padovani A, Barone P, TITAN Study Group, Erro, R, Pilotto, A, Esposito, M, Olivola, E, Nicoletti, A, Lazzeri, G, Magistrelli, L, Dallocchio, C, Marchese, R, Bologna, M, Tessitore, A, Misceo, S, Gigante, Af, Terranova, C, Moschella, V, di Biase, L, Di Giacopo, R, Morgante, F, Valentino, F, De Rosa, A, Trinchillo, A, Malaguti, Mc, Brusa, L, Matinella, A, Di Biasio, F, Paparella, G, De Micco, R, Contaldi, E, Modugno, N, Di Fonzo, A, Padovani, A, Barone, P, and TITAN Study, Group

Abstract

INTRODUCTION: The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. METHODS: The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. RESULTS: In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. CONCLUSIONS: The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.

Published
2022

22. Phenotypic Variability in Acquired and Idiopathic Dystonia

Author

Defazio, G, Gigante, Af, Erro, R, Belvisi, D, Esposito, M, Trinchillo, A, De Joanna, G, Ceravolo, R, Mazzucchi, S, Unti, E, Barone, P, Scannapieco, S, Cotelli, Ms, Turla, M, Bianchi, M, Bertolasi, L, Pisani, A, Valentino, F, Altavista, Mc, Moschella, V, Girlanda, P, Terranova, C, Bono, F, Spano, G, Fabbrini, G, Ferrazzano, G, Albanese, A, Castagna, A, Cassano, D, Moja, Mc, Pellicciari, R, Bentivoglio, Ar, Eleopra, R, Cossu, G, Ercoli, T, Mascia, Mm, Di Biasio, F, Misceo, S, Magistrelli, L, Romano, M, Scaglione, Clm, Tinazzi, M, Maderna, L, Zibetti, M, and Berardelli, A

Subjects
clinical phenomenology, acquired, idiopathic, dystonia
Published
2023

25. The role of peritoneal lavage in benign gynecologic laparoscopic surgery.

Author

DE CICCO NARDONE, C., FICAROLA, F., PLOTTI, F., MONTERA, R., FEOLE, L., RAMPELLO, S., MESSINA, G., LUVERO, D., MARCI, R., ANGIOLI, R., and TERRANOVA, C.

Abstract

OBJECTIVE: Laparoscopic surgery offers many advantages compared to invasive surgery but one of the main problems is postoperative pain, partially resulting from the peritoneal inflammatory process mediated by inflammatory cytokines. The rationale of this study is that intraperitoneal washing could remove inflammatory mediators that are the cause of postoperative pain and could help in the removal of CO2 from the abdominal cavity. This article aims to analyze the effects of peritoneal lavage in the reduction of postoperative shoulder pain. PATIENTS AND METHODS: 277 patients enrolled to undergo laparoscopic gynecologic surgery were included in the study. Women are randomized into two groups, according to the use or non-use of peritoneal lavage with saline solution at the end of laparoscopic gynecological major procedures. RESULTS: Data show that the peritoneal lavage can significantly reduce postoperative pain in the first 36 hours after surgery, as well as patients’ requests for analgesics: during the first 3 postoperative days, requests for paracetamol were lower in the YW (Yes Washing) group than the NW (No Washing) group (77 vs. 101; p<0.05); similar results are obtained considering ketorolac administration (62 vs. 71; p<0.05). CONCLUSIONS: Peritoneal lavage after gynecological laparoscopic procedures may be effective in the reduction of postoperative pain and use of analgesics. [ABSTRACT FROM AUTHOR]

Published
2023

27. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings (Neurological Sciences, (2022), 10.1007/s10072-022-06104-w)

Author

Erro, R, Pilotto, A, Esposito, M, Olivola, E, Nicoletti, A, Lazzeri, G, Magistrelli, L, Dallocchio, C, Marchese, R, Bologna, M, Tessitore, A, Misceo, S, Gigante, Af, Terranova, C, Moschella, V, di Biase, L, Di Giacopo, R, Morgante, F, Valentino, F, De Rosa, A, Trinchillo, A, Malaguti, Mc, Brusa, L, Matinella, A, Di Biasio, F, Paparella, G, De Micco, R, Contaldi, E, Modugno, N, Di Fonzo, A, Padovani, A, and Barone, P

Published
2022

28. PS-inSAR data analysis: Pre-seismic ground deformation in the 2009 L'Aquila earthquake region

Author

Nardo S., Ascione A., Mazzoli S., Terranova C., Vilardo G., Nardo, S., Ascione, A., Mazzoli, S., Terranova, C., and Vilardo, G.

Subjects
Central Apennine, Pre-seismic, Ground deformation, PS-InSAR, Earthquake precursor, 6.3 L’Aquila earthquake
Abstract

The accuracy of the millimetre-scale measurements made so far by the SAR systems, as well as the multi-temporal analysis methodologies, have provided impressive images of surface displacements in areas affected by strong earthquakes, and contributed to constrain the geometric and kinematic features of earthquake generating faults. The multi-temporal analysis of InSAR data is also being acknowledged as promising for the search of earthquake precursors. We have applied the multi-temporal PS-InSAR technique to the detection of pre- to post-seismic ground displacements in the region struck by the normal faulting 2009 L’Aquila earthquake. We have used ERS and ENVISAT PS-data sets from both ascending and descending orbits, covering a 20-year long time span. On the yearly-scale, we have identified a pre-seismic displacement pattern, which consists of opposite vertical motions that have affected the blocks in the hanging wall and footwall of the structure that is recognised as the surface trace of the earthquake-generating fault. In particular, we have highlighted a pre-seismic uplift for 4-5 years followed by subsidence (starting 6-8 months prior to the earthquake) of the hanging wall block, coeval to opposite vertical motions of the footwall block. We suggest that such a displacement pattern may represent an earthquake precursor signal.

Published
2020

29. Measurement of sound speed vs. depth in South Pole ice for neutrino astronomy

Author

Abbasi, R., Abdou, Y., Ackermann, M., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Bolmont, J., Böser, S., Botner, O., Bradley, L., Braun, J., Breder, D., Castermans, T., Chirkin, D., Christy, B., Clem, J., Cohen, S., Cowen, D.F., D’Agostino, M.V., Danninger, M., Day, C.T., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Diaz-Velez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Edwards, W.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J.A., Gozzini, R., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Heise, J., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kenny, P., Kiryluk, J., Kislat, F., Klein, S.R., Klepser, S., Knops, S., Kohnen, G., Kolanoski, H., Köpke, L., Kowalski, M., Kowarik, T., Krasberg, M., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Leich, H., Lennarz, D., Lucke, A., Lundberg, J., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., McParland, C.P., Meagher, K., Merck, M., Mészáros, P., Middell, E., Milke, N., Miyamoto, H., Mohr, A., Montaruli, T., Morse, R., Movit, S.M., Münich, K., Nahnhauer, R., Nam, J.W., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Patton, S., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Potthoff, N., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ryckbosch, D., Sander, H.-G., Sarkar, S., Satalecka, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoufer, M.C., Stoyanov, S., Strahler, E.A., Straszheim, T., Sulanke, K.-H., Sullivan, G.W., Swillens, Q., Taboada, I., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Tluczykont, M., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., Vogt, C., Voigt, B., Walck, C., Waldenmaier, T., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebusch, C.H., Wiedemann, A., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, X.W., Yodh, G., and Yoshida, S.

Published
2010
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30. Calibration and characterization of the IceCube photomultiplier tube

Author

Abbasi, R., Abdou, Y., Abu-Zayyad, T., Adams, J., Aguilar, J.A., Ahlers, M., Andeen, K., Auffenberg, J., Bai, X., Baker, M., Barwick, S.W., Bay, R., Bazo Alba, J.L., Beattie, K., Beatty, J.J., Bechet, S., Becker, J.K., Becker, K.-H., Benabderrahmane, M.L., Berdermann, J., Berghaus, P., Berley, D., Bernardini, E., Bertrand, D., Besson, D.Z., Bissok, M., Blaufuss, E., Boersma, D.J., Bohm, C., Botner, O., Bradley, L., Braun, J., Buitink, S., Carson, M., Chirkin, D., Christy, B., Clem, J., Cohen, S., Colnard, C., Cowen, D.F., D’Agostino, M.V., Danninger, M., De Clercq, C., Demirörs, L., Depaepe, O., Descamps, F., Desiati, P., de Vries-Uiterweerd, G., DeYoung, T., Díaz-Vélez, J.C., Dreyer, J., Dumm, J.P., Duvoort, M.R., Ehrlich, R., Eisch, J., Ellsworth, R.W., Engdegård, O., Euler, S., Evenson, P.A., Fadiran, O., Fazely, A.R., Feusels, T., Filimonov, K., Finley, C., Foerster, M.M., Fox, B.D., Franckowiak, A., Franke, R., Gaisser, T.K., Gallagher, J., Ganugapati, R., Geisler, M., Gerhardt, L., Gladstone, L., Goldschmidt, A., Goodman, J.A., Grant, D., Griesel, T., Groß, A., Grullon, S., Gunasingha, R.M., Gurtner, M., Ha, C., Hallgren, A., Halzen, F., Han, K., Hanson, K., Hasegawa, Y., Haugen, J., Helbing, K., Herquet, P., Hickford, S., Hill, G.C., Hoffman, K.D., Homeier, A., Hoshina, K., Hubert, D., Huelsnitz, W., Hülß, J.-P., Hulth, P.O., Hultqvist, K., Hussain, S., Imlay, R.L., Inaba, M., Ishihara, A., Jacobsen, J., Japaridze, G.S., Johansson, H., Joseph, J.M., Kampert, K.-H., Kappes, A., Karg, T., Karle, A., Kelley, J.L., Kemming, N., Kenny, P., Kiryluk, J., Kislat, F., Kitamura, N., Klein, S.R., Knops, S., Kohnen, G., Kolanoski, H., Köpke, L., Koskinen, D.J., Kowalski, M., Kowarik, T., Krasberg, M., Krings, T., Kroll, G., Kuehn, K., Kuwabara, T., Labare, M., Lafebre, S., Laihem, K., Landsman, H., Lauer, R., Laundrie, A., Lehmann, R., Lennarz, D., Lünemann, J., Madsen, J., Majumdar, P., Maruyama, R., Mase, K., Matis, H.S., Matusik, M., Meagher, K., Merck, M., Mészáros, P., Meures, T., Middell, E., Milke, N., Miyamoto, H., Montaruli, T., Morse, R., Movit, S.M., Nahnhauer, R., Nam, J.W., Naumann, U., Nießen, P., Nygren, D.R., Odrowski, S., Olivas, A., Olivo, M., Ono, M., Panknin, S., Paul, L., Pérez de los Heros, C., Petrovic, J., Piegsa, A., Pieloth, D., Pohl, A.C., Porrata, R., Posselt, J., Price, P.B., Prikockis, M., Przybylski, G.T., Rawlins, K., Redl, P., Resconi, E., Rhode, W., Ribordy, M., Rizzo, A., Robl, P., Rodrigues, J.P., Roth, P., Rothmaier, F., Rott, C., Roucelle, C., Rutledge, D., Ruzybayev, B., Ryckbosch, D., Sander, H.-G., Sandstrom, P., Sarkar, S., Schatto, K., Schlenstedt, S., Schmidt, T., Schneider, D., Schukraft, A., Schultes, A., Schulz, O., Schunck, M., Seckel, D., Semburg, B., Seo, S.H., Sestayo, Y., Seunarine, S., Silvestri, A., Slipak, A., Spiczak, G.M., Spiering, C., Stamatikos, M., Stanev, T., Stephens, G., Stezelberger, T., Stokstad, R.G., Stoyanov, S., Strahler, E.A., Straszheim, T., Sullivan, G.W., Swillens, Q., Taboada, I., Tamburro, A., Tarasova, O., Tepe, A., Ter-Antonyan, S., Terranova, C., Tilav, S., Toale, P.A., Tosi, D., Turčan, D., van Eijndhoven, N., Vandenbroucke, J., Van Overloop, A., van Santen, J., Voigt, B., Wahl, D., Walck, C., Waldenmaier, T., Wallraff, M., Walter, M., Wendt, C., Westerhoff, S., Whitehorn, N., Wiebe, K., Wiebusch, C.H., Wikström, G., Williams, D.R., Wischnewski, R., Wissing, H., Woschnagg, K., Xu, C., Xu, X.W., Yodh, G., Yoshida, S., and Zarzhitsky, P.

Published
2010
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31. O004/#393 Does intensive follow-up improve overall survivalin endometrial cancer patients? Results from the totem randomized controlled trial

Author

Zola, P, primary, Ciccone, G, additional, Angioli, R, additional, Terranova, C, additional, Piovano, E, additional, Fuso, L, additional, Di Cuonzo, D, additional, Peirano, E, additional, Perrone, AM, additional, Mandato, VD, additional, Zavallone, L, additional, Chiudinelli, F, additional, Berretta, R, additional, Loda, S, additional, Greggi, S, additional, Adorni, M, additional, Busato, E, additional, Comerci, G, additional, Fambrini, M, additional, and Ferrero, A, additional

Published
2021
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33. Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site

Author

Ercoli, T., Erro, R., Fabbrini, G., Pellicciari, R., Girlanda, P., Terranova, C., Avanzino, L., Di Biasio, F., Barone, P., Esposito, M., De Joanna, G., Eleopra, R., Bono, F., Manzo, L., Bentivoglio, Anna Rita, Petracca, Martina, Mascia, M. M., Albanese, A., Castagna, A., Ceravolo, R., Altavista, M. C., Scaglione, C., Magistrelli, L., Zibetti, M., Bertolasi, L., Coletti Moja, M., Cotelli, M. S., Cossu, G., Minafra, B., Pisani, A., Misceo, S., Modugno, N., Romano, M., Cassano, D., Berardelli, A., Defazio, G., Cimino, P., Scannapieco, S., Ferrazzano, G., Brigandi, A., Habetswallner, F., Pascarella, A., Ialongo, Tamara, Ramella, M., Mazzucchi, S., Moschella, V., Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Petracca M., Ialongo T., Ercoli, T., Erro, R., Fabbrini, G., Pellicciari, R., Girlanda, P., Terranova, C., Avanzino, L., Di Biasio, F., Barone, P., Esposito, M., De Joanna, G., Eleopra, R., Bono, F., Manzo, L., Bentivoglio, Anna Rita, Petracca, Martina, Mascia, M. M., Albanese, A., Castagna, A., Ceravolo, R., Altavista, M. C., Scaglione, C., Magistrelli, L., Zibetti, M., Bertolasi, L., Coletti Moja, M., Cotelli, M. S., Cossu, G., Minafra, B., Pisani, A., Misceo, S., Modugno, N., Romano, M., Cassano, D., Berardelli, A., Defazio, G., Cimino, P., Scannapieco, S., Ferrazzano, G., Brigandi, A., Habetswallner, F., Pascarella, A., Ialongo, Tamara, Ramella, M., Mazzucchi, S., Moschella, V., Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Petracca M., and Ialongo T.

Abstract

Background: Adult-onset focal dystonia can spread to involve one, or less frequently, two additional body regions. Spread of focal dystonia to a third body site is not fully characterized. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry, enrolling patients with segmental/multifocal dystonia involving at least two parts of the body or more. Survival analysis estimated the relationship between dystonia features and spread to a third body part. Results: We identified 340 patients with segmental/multifocal dystonia involving at least two body parts. Spread of dystonia to a third body site occurred in 42/241 patients (17.4%) with focal onset and 10/99 patients (10.1%) with segmental/multifocal dystonia at onset. The former had a greater tendency to spread than patients with segmental/multifocal dystonia at onset. Gender, years of schooling, comorbidity, family history of dystonia/tremor, age at dystonia onset, and disease duration could not predict spread to a third body site. Among patients with focal onset in different body parts (cranial, cervical, and upper limb regions), there was no association between site of focal dystonia onset and risk of spread to a third body site. Discussion and conclusion: Spread to a third body site occurs in a relative low percentage of patients with idiopathic adult-onset dystonia affecting two body parts. Regardless of the site of dystonia onset and of other demographic/clinical variables, focal onset seems to confer a greater risk of spread to a third body site in comparison to patients with segmental/multifocal dystonia at onset.

Published
2021

37. Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs)

Author

Silveira-Moriyama, L., Schwingenschuh, P., O'Donnell, A., Schneider, S.A., Mir, P., Carrillo, F., Terranova, C., Petrie, A., Grosset, D.G., Quinn, N.P., Bhatia, K.P., and Lees, A.J.

Subjects
Parkinson's disease -- Diagnosis, Parkinson's disease -- Development and progression, Parkinson's disease -- Research, PET imaging -- Usage, PET imaging -- Research, Tremor -- Research, Dopaminergic mechanisms -- Physiological aspects, Dopaminergic mechanisms -- Research, Health, Psychology and mental health
Published
2009

39. Prenatal genetic diagnosis: fetal therapy as a possible solution to a positive test

Author

Kiani, A. K., Paolacci, S., Scanzano, P., Michelini, S., Capodicasa, N., D'Agruma, L., Notarangelo, A., Tonini, G., Piccinelli, D., Farshid, K. R., Petralia, P., Fulcheri, E., Buffelli, F., Chiurazzi, P., Terranova, C., Plotti, F., Angioli, R., Castori, M., Pos, O., Szemes, T., and Bertelli, M.

Subjects
prenatal gene therapy, Fetal Therapies, prenatal diagnosis, prenatal stem cell therapy, Pregnancy, fetal drug therapy, Humans, Original Article, Female, prenatal interventions, Aneuploidy, Hernias, Diaphragmatic, Congenital, Fetal drug therapy, Prenatal diagnosis, Prenatal gene therapy, Prenatal interventions, Prenatal stem cell therapy
Abstract

Background: Fetal abnormalities cause 20% of perinatal deaths. Advances in prenatal genetic and other types of screening offer great opportunities for identifying high risk pregnancies. Methods: Through a literature search, here we summarise what are the prenatal diagnostic technique that are being used and how those techniques may allow for prenatal interventions. Results: Next generation sequencing and non-invasive prenatal testing are fundamental for clinical diagnostics because of their sensitivity and accuracy in identifying point mutations, aneuploidies, and microdeletions, respectively. Timely identification of genetic disorders and other fetal abnormalities enables early intervention, such as in-utero gene therapy, fetal drug therapy and prenatal surgery. Conclusion: Prenatal intervention is mainly focused on conditions that may cause death or lifelong disabilities, like spina bifida, congenital diaphragm hernia and sacrococcygeal teratoma; and may be an alternative therapeutic option to termination of pregnancy. However, it is not yet widely available, due to lack of specialized centers. (www.actabiomedica.it)

Published
2020

41. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment

Author

Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., Angioli, R., Cianci S., Scaletta G., Marchetti C. (ORCID:0000-0001-7098-8956), Fagotti A. (ORCID:0000-0001-5579-335X), Scambia G. (ORCID:0000-0003-2758-1063), Plotti, F., Terranova, C., Luvero, D., Bartolone, M., Messina, G., Feole, L., Cianci, S., Scaletta, G., Marchetti, C., Di Donato, V., Fagotti, A., Scambia, G., Benedetti Panici, P., Angioli, R., Cianci S., Scaletta G., Marchetti C. (ORCID:0000-0001-7098-8956), Fagotti A. (ORCID:0000-0001-5579-335X), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Introduction: Diet may influence various aspects of human health. In fact, it is well known that diet can favour or not the development of various human pathologies, like diabetes, hypertension, and hypercholesterolaemia. Interestingly, diet has an influence in cancer development too (e.g., this relation has been studied for pancreatic, colonic, gastric, and breast cancers). Between the mechanisms that could explain this relation, there is epigenetic. In fact, thanks to epigenetic reprogramming, certain substances introduced with diet could affect gene expression, especially of those genes involved in cells' proliferation and growth. In recent years, some studies have been published about the role that diet could have on chemotherapy outcome. Especially, various studies have analysed the effects of fasting and ketogenic diet (KD) during chemotherapy. The aim of this study is to summarize scientific evidences about diet and its effects on chemotherapy on humans and to better understand if these approaches deserve to be further investigated and might be suitable and beneficial during cancer treatment. Materials and Methods: We performed an electronic literature search of the PubMed database, using the combination of following terms: "fasting"or "ketogenic"with "chemotherapy,""cancer treatment."We included studies on humans about fasting and KD during chemotherapy, excluding reviews, case series including <10 patients, studies conducted on animals or limited to radiotherapy treatment, and studies that were mostly about molecular mechanisms. Results/Discussion In our analysis we included 4 studies (1 randomized controlled trial, 1 retrospective study, and 2 prospective pilot studies) about KD and 4 studies (1 prospective cohort study, 1 case series report, and 2 randomized trials) about fasting during oncological treatments. Authors suggested an improvement of quality of life (QoL) and fatigue in patients under chemotherapy, especially in the 8 days after chemotherap

Published
2020

42. Front-line chemo-immunotherapy with carboplatin-paclitaxel using oregovomab indirect immunization in advanced ovarian cancer: A randomized phase II study

Author

Brewer, M., Angioli, R., Scambia, Giovanni, Lorusso, D., Terranova, C., Panici, P. B., Raspagliesi, F., Scollo, P., Plotti, F., Ferrandina, Maria Gabriella, Salutari, Vanda, Ricci, C., Braly, P., Holloway, R., Method, M., Madiyalakan, M., Bayever, E., Nicodemus, C., Scambia G. (ORCID:0000-0003-2758-1063), Ferrandina G. (ORCID:0000-0003-4672-4197), Salutari V., Brewer, M., Angioli, R., Scambia, Giovanni, Lorusso, D., Terranova, C., Panici, P. B., Raspagliesi, F., Scollo, P., Plotti, F., Ferrandina, Maria Gabriella, Salutari, Vanda, Ricci, C., Braly, P., Holloway, R., Method, M., Madiyalakan, M., Bayever, E., Nicodemus, C., Scambia G. (ORCID:0000-0003-2758-1063), Ferrandina G. (ORCID:0000-0003-4672-4197), and Salutari V.

Abstract

Background: This randomized phase II study tested the hypothesis that schedule dependent chemo-immunotherapy with oregovomab improves progression free survival (PFS) and overall survival (OS) in optimally resected, Stage III/IV ovarian cancer. Methods: Patients from both academic centers and private practice in the US and Italy with Stage III/IV optimally cytoreduced ovarian cancer were randomized to standard six cycle IV carboplatin-paclitaxel chemotherapy (CP) versus CP plus four immunizations with oregovomab (CPO). A translational assessment of a cellular immune response was the primary endpoint; PFS and OS were measured as secondary endpoints. Findings: 97 patients at thirteen centers were accrued to the protocol, 47 to CPO and 50 to CP. Technical issues led to inconsistent performance of the primary CA125 ELISPOT leading to unevaluable results. At a median follow up of 42 months, PFS and OS outcomes revealed an unexpectedly large treatment effect for CPO relative to CP alone, with median PFS of 41.8 months (95% C.I.: 21.8 - N.E.) for CPO and 12.2 months (10.4–18.6) for CP (p = 0.0027, HR 0.46, CI 0.28–0.7). For OS, the median for CPO has not yet been reached (NE) (45.2-NE) and for CP was 43.2 months (31.8-NE) (p = 0.043, HR 0.35, CI 0.16–0.74). The oregovomab treatment resulted in no change in toxicity profile from CP. Interpretation: The previously identified potential clinical benefit of IV CP when administered with oregovomab was further refined in this randomized phase II study. Increases of PFS and OS of statistically and clinically significant magnitude were evident in this study of a front line chemo-immunotherapy treatment of ovarian cancer.

Published
2020

47. Calibration and validation of rainfall thresholds for shallow landslide forecasting in Sicily, southern Italy

Author

Stefano Luigi Gariano (a, Maria Teresa Brunetti (a, Giulio Iovine (c), Massimo Melillo (a), Silvia Peruccacci (a), Oreste Terranova (c), Carmela Vennari (d, and Fausto Guzzetti (c)

Subjects
Contingency table, Warning system, Receiver operating characteristic, Meteorology, Skill score, Nonparametric statistics, Forecast skill, Landslide, Rainfall threshold, Validation, Early warning system, Shallow landslide, Sicily, Geology, Earth-Surface Processes, Event (probability theory)
Abstract

Empirical rainfall thresholds are tools to forecast the possible occurrence of rainfall-induced shallow landslides. Accurate prediction of landslide occurrence requires reliable thresholds, which need to be properly validated before their use in operational warning systems. We exploited a catalogue of 200 rainfall conditions that have resulted in at least 223 shallow landslides in Sicily, southern Italy, in the 11-year period 2002–2011, to determine regional event duration–cumulated event rainfall (ED) thresholds for shallow landslide occurrence. We computed ED thresholds for different exceedance probability levels and determined the uncertainty associated to the thresholds using a consolidated bootstrap nonparametric technique. We further determined subregional thresholds, and we studied the role of lithology and seasonal periods in the initiation of shallow landslides in Sicily. Next, we validated the regional rainfall thresholds using 29 rainfall conditions that have resulted in 42 shallow landslides in Sicily in 2012. We based the validation on contingency tables, skill scores, and a receiver operating characteristic (ROC) analysis for thresholds at different exceedance probability levels, from 1% to 50%. Validation of rainfall thresholds is hampered by lack of information on landslide occurrence. Therefore, we considered the effects of variations in the contingencies and the skill scores caused by lack of information. Based on the results obtained, we propose a general methodology for the objective identification of a threshold that provides an optimal balance between maximization of correct predictions and minimization of incorrect predictions, including missed and false alarms. We expect that the methodology will increase the reliability of rainfall thresholds, fostering the operational use of validated rainfall thresholds in operational early warning system for regional shallow landslide forecasting.

Published
2015

48. Pain processing in functional and idiopathic dystonia: An exploratory study

Author

Morgante, F, Matinella, A, Andrenelli, E, Ricciardi, L, Allegra, C, Terranova, C, Girlanda, P, and Tinazzi, M

Subjects
Adult, Male, Pain Threshold, cervical dystonia, emotions, functional movement disorders, pain, psychogenic dystonia, Pain, Middle Aged, Severity of Illness Index, Statistics, Nonparametric, nervous system diseases, Dystonia, Young Adult, Touch, Case-Control Studies, Physical Stimulation, otorhinolaryngologic diseases, Humans, Female, Pain Measurement
Abstract

BACKGROUND: Pain is often experienced by patients with functional dystonia and idiopathic cervical dystonia and is likely to be determined by different neural mechanisms. OBJECTIVE: In this exploratory study, we tested the sensory-discriminative and cognitive-emotional component of pain in patients with functional and idiopathic dystonia. METHODS: Ten patients with idiopathic cervical dystonia, 12 patients with functional dystonia, and 16 age- and sex-matched healthy controls underwent psychophysical testing of tactile and pain thresholds and pain tolerance. We delivered electrical pulses of increasing intensity to the index finger of each hand and the halluces of each foot. Pain threshold and pain tolerance were respectively defined as the (1) intensity at which sensation changed from unpainful to faintly painful and (2) intensity at which painful sensation was intolerable. RESULTS: No differences were found between the three groups for tactile and pain thresholds assessed in hands and feet. Pain tolerance was significantly increased in all body regions only in functional dystonia. Patients with continuous functional dystonia had higher pain tolerance compared to subjects with paroxysmal functional dystonia and idiopathic cervical dystonia. There was no correlation between pain tolerance and pain scores, depression, anxiety, disease duration, and motor disability in both groups. CONCLUSIONS: Patients with functional dystonia have a dissociation between the sensory-discriminative and cognitive-emotional components of pain, as revealed by normal pain thresholds and increased pain tolerance. Abnormal connectivity between the motor and limbic systems might account for abnormal pain processing in functional dystonia. © 2018 International Parkinson and Movement Disorder Society.

Published
2017

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