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7 results on '"Teri-TB Ngo"'

2. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

Author

Yoshinori Aso, Robert P Ray, Xi Long, Daniel Bushey, Karol Cichewicz, Teri-TB Ngo, Brandi Sharp, Christina Christoforou, Amy Hu, Andrew L Lemire, Paul Tillberg, Jay Hirsh, Ashok Litwin-Kumar, and Gerald M Rubin

Subjects
associative learning, memory dynamics, dopamine, cotransmitter, nitric oxide, mushroom body, Medicine, Science, Biology (General), QH301-705.5
Abstract

Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso and Rubin, 2016). Here, we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in Drosophila. NO’s effects develop more slowly than those of dopamine and depend on soluble guanylate cyclase in postsynaptic Kenyon cells. NO acts antagonistically to dopamine; it shortens memory retention and facilitates the rapid updating of memories. The interplay of NO and dopamine enables memories stored in local domains along Kenyon cell axons to be specialized for predicting the value of odors based only on recent events. Our results provide key mechanistic insights into how diverse memory dynamics are established in parallel memory systems.

Published
2019
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3. The neuronal architecture of the mushroom body provides a logic for associative learning

Author

Yoshinori Aso, Daisuke Hattori, Yang Yu, Rebecca M Johnston, Nirmala A Iyer, Teri-TB Ngo, Heather Dionne, LF Abbott, Richard Axel, Hiromu Tanimoto, and Gerald M Rubin

Subjects
mushroom body, olfactory learning, associative memory, neuronal circuit, dopamine, plasticity, Medicine, Science, Biology (General), QH301-705.5
Abstract

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell–MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

Published
2014
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5. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

Author

Christina Christoforou, Brandi Sharp, Teri-TB Ngo, Yoshinori Aso, Andrew L. Lemire, Ashok Litwin-Kumar, Gerald M. Rubin, Xi Long, Karol Cichewicz, Robert P. Ray, and Jay Hirsh

Subjects
Kenyon cell, Dopaminergic, Biology, Associative learning, chemistry.chemical_compound, chemistry, Dopamine, Postsynaptic potential, Synaptic plasticity, Mushroom bodies, medicine, Neurotransmitter, Neuroscience, medicine.drug
Abstract

SummaryAnimals employ multiple and distributed neuronal networks with diverse learning rules and synaptic plasticity dynamics to record distinct temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso & Rubin 2016). Here we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in Drosophila. NO’s effects develop more slowly than those of dopamine and depend on soluble guanylate cyclase in postsynaptic Kenyon cells. NO acts antagonistically to dopamine; it shortens memory retention and facilitates the rapid updating of memories. The interplay of NO and dopamine enables memories stored in local domains along Kenyon cell axons to be specialized for predicting the value of odors based only on recent events. Our results provide key mechanistic insights into how diverse memory dynamics are established in parallel memory systems.

Published
2019
Full Text
View/download PDF

6. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

Author

Gerald M. Rubin, Teri-TB Ngo, Brandi Sharp, Christina Christoforou, Robert P. Ray, Yoshinori Aso, Paul W. Tillberg, Ashok Litwin-Kumar, Amy Hu, Karol Cichewicz, Xi Long, Andrew L. Lemire, Daniel Bushey, and Jay Hirsh

Subjects
Kenyon cell, QH301-705.5, Science, Dopamine, Biology, associative learning, Nitric Oxide, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Postsynaptic potential, Memory, medicine, Animals, Drosophila Proteins, Learning, Biology (General), Neurotransmitter, Mushroom Bodies, 030304 developmental biology, 0303 health sciences, Neurotransmitter Agents, D. melanogaster, General Immunology and Microbiology, General Neuroscience, Dopaminergic Neurons, Dopaminergic, Correction, General Medicine, mushroom body, Associative learning, Smell, Drosophila melanogaster, chemistry, Synaptic plasticity, Mushroom bodies, Odorants, Medicine, memory dynamics, cotransmitter, Neuroscience, 030217 neurology & neurosurgery, Research Article, medicine.drug
Abstract

Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso and Rubin, 2016). Here, we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in Drosophila. NO’s effects develop more slowly than those of dopamine and depend on soluble guanylate cyclase in postsynaptic Kenyon cells. NO acts antagonistically to dopamine; it shortens memory retention and facilitates the rapid updating of memories. The interplay of NO and dopamine enables memories stored in local domains along Kenyon cell axons to be specialized for predicting the value of odors based only on recent events. Our results provide key mechanistic insights into how diverse memory dynamics are established in parallel memory systems.

Published
2019

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