Search

Your search keyword '"Teresa M.J. Beary"' showing total 1 results
Start Over Author "Teresa M.J. Beary"
1 results on '"Teresa M.J. Beary"'

1. Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors

Author

Teresa M.J. Beary, Anthony S. Breitbach, Thanit Praneenararat, and Helen E. Blackwell

Subjects
Acylation, Clinical Biochemistry, Pharmaceutical Science, Receptors, Cell Surface, medicine.disease_cause, Biochemistry, Chromatography, Affinity, Article, chemistry.chemical_compound, Affinity chromatography, 4-Butyrolactone, Drug Discovery, medicine, Molecule, Receptor, Molecular Biology, chemistry.chemical_classification, Pseudomonas aeruginosa, Chemistry, Organic Chemistry, Quorum Sensing, Combinatorial chemistry, Quorum sensing, L-homoserine, Molecular Medicine, Agarose, Electrophoresis, Polyacrylamide Gel, Lactone
Abstract

The design and synthesis of an agarose resin functionalized with a Gram-negative quorum sensing (QS) signaling molecule analogue is described. The modified resin was utilized in affinity pull-down assays to successfully isolate QscR, a LuxR-type QS receptor from Pseudomonas aeruginosa. This resin may facilitate the identification of novel QS signal receptors using affinity chromatography techniques.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results