4 results on '"Terenghi L."'
Search Results
2. Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion
- Author
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Angelica Bava, Valentina Cagnetta, Tiziana Giovannini, Sauro Biscotto, Sonia Cremascoli, Marco Candela, Laura Terenghi, Lucia Rapisarda, Maurizio Cazzaniga, Ernesto Losavio, Maria Chiara Bulzamini, Maria Cristina Pagliacci, Gabriele Bazzocchi, Federica D’Amico, Luisa De Palma, Maria Pia Onesta, Beatrice Aiachini, Patrizia Brigidi, Carlotte Kiekens, Antonino Massone, Michele Scarazzato, Mirco Castiglioni, Giuseppina Frasca, Mimosa Balloni, Claudia Oggerino, Silvia Turroni, Bazzocchi G., Turroni S., Bulzamini M.C., D'Amico F., Bava A., Castiglioni M., Cagnetta V., Losavio E., Cazzaniga M., Terenghi L., De Palma L., Frasca G., Aiachini B., Cremascoli S., Massone A., Oggerino C., Onesta M.P., Rapisarda L., Pagliacci M.C., Biscotto S., Scarazzato M., Giovannini T., Balloni M., Candela M., Brigidi P., and Kiekens C.
- Subjects
0301 basic medicine ,Male ,Disease ,Gut flora ,Severity of Illness Index ,Feces ,0302 clinical medicine ,RNA, Ribosomal, 16S ,Defecation ,Spinal cord injury ,education.field_of_study ,Multidisciplinary ,Spinal Cord Injurie ,biology ,Middle Aged ,Traumatic injury ,Italy ,Acute Disease ,Medicine ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,Case-Control Studie ,Human ,Adult ,Science ,Population ,Spinal cord diseases ,Article ,Lesion ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,Microbiome ,education ,Spinal Cord Injuries ,Aged ,business.industry ,biology.organism_classification ,medicine.disease ,Gastrointestinal Microbiome ,030104 developmental biology ,Case-Control Studies ,Immunology ,Dysbiosis ,Fece ,business - Abstract
After spinal cord injury (SCI), patients face many physical and psychological issues including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut microbiota has recently been suggested to influence the course of the disease in these patients. However, to date only two studies have profiled the gut microbiota in SCI patients, months after a traumatic injury. Here we characterized the gut microbiota in a large Italian SCI population, within a short time from a not only traumatic injury. Feces were collected within the first week at the rehabilitation center (no later than 60 days after SCI), and profiled by 16S rRNA gene-based next-generation sequencing. Microbial profiles were compared to those publicly available of healthy age- and gender-matched Italians, and correlated to patient metadata, including type of SCI, spinal unit location, nutrition and concomitant antibiotic therapies. The gut microbiota of SCI patients shows distinct dysbiotic signatures, i.e. increase in potentially pathogenic, pro-inflammatory and mucus-degrading bacteria, and depletion of short-chain fatty acid producers. While robust to most host variables, such dysbiosis varies by lesion level and completeness, with the most neurologically impaired patients showing an even more unbalanced microbial profile. The SCI-related gut microbiome dysbiosis is very likely secondary to injury and closely related to the degree of completeness and severity of the lesion, regardless of etiology and time interval. This microbial layout could variously contribute to increased gut permeability and inflammation, potentially predisposing patients to the onset of severe comorbidities.
- Published
- 2021
3. Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion.
- Author
-
Bazzocchi G, Turroni S, Bulzamini MC, D'Amico F, Bava A, Castiglioni M, Cagnetta V, Losavio E, Cazzaniga M, Terenghi L, De Palma L, Frasca G, Aiachini B, Cremascoli S, Massone A, Oggerino C, Onesta MP, Rapisarda L, Pagliacci MC, Biscotto S, Scarazzato M, Giovannini T, Balloni M, Candela M, Brigidi P, and Kiekens C
- Subjects
- Acute Disease, Adult, Aged, Case-Control Studies, Defecation, Feces microbiology, Female, Humans, Italy, Male, Middle Aged, RNA, Ribosomal, 16S genetics, Severity of Illness Index, Spinal Cord Injuries pathology, Spinal Cord Injuries physiopathology, Young Adult, Gastrointestinal Microbiome, Spinal Cord Injuries microbiology
- Abstract
After spinal cord injury (SCI), patients face many physical and psychological issues including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut microbiota has recently been suggested to influence the course of the disease in these patients. However, to date only two studies have profiled the gut microbiota in SCI patients, months after a traumatic injury. Here we characterized the gut microbiota in a large Italian SCI population, within a short time from a not only traumatic injury. Feces were collected within the first week at the rehabilitation center (no later than 60 days after SCI), and profiled by 16S rRNA gene-based next-generation sequencing. Microbial profiles were compared to those publicly available of healthy age- and gender-matched Italians, and correlated to patient metadata, including type of SCI, spinal unit location, nutrition and concomitant antibiotic therapies. The gut microbiota of SCI patients shows distinct dysbiotic signatures, i.e. increase in potentially pathogenic, pro-inflammatory and mucus-degrading bacteria, and depletion of short-chain fatty acid producers. While robust to most host variables, such dysbiosis varies by lesion level and completeness, with the most neurologically impaired patients showing an even more unbalanced microbial profile. The SCI-related gut microbiome dysbiosis is very likely secondary to injury and closely related to the degree of completeness and severity of the lesion, regardless of etiology and time interval. This microbial layout could variously contribute to increased gut permeability and inflammation, potentially predisposing patients to the onset of severe comorbidities.
- Published
- 2021
- Full Text
- View/download PDF
4. Prognostic value of electrocardiograms, ventricular late potentials, ventricular arrhythmias, and left ventricular systolic dysfunction in patients with Duchenne muscular dystrophy.
- Author
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Corrado G, Lissoni A, Beretta S, Terenghi L, Tadeo G, Foglia-Manzillo G, Tagliagambe LM, Spata M, and Santarone M
- Subjects
- Adolescent, Adult, Female, Humans, Italy, Male, Predictive Value of Tests, Prognosis, ROC Curve, Registries, Survival Analysis, Electrocardiography, Heart Conduction System physiopathology, Heart Ventricles physiopathology, Muscular Dystrophy, Duchenne physiopathology, Tachycardia, Ventricular physiopathology, Ventricular Dysfunction, Left physiopathology
- Abstract
Myocardial involvement is a common finding in patients with Duchenne-type muscular dystrophy (DMD). Nevertheless, the prognostic values of standard electrocardiogram (ECG), ventricular arrhythmias, ventricular late potentials (LPs), and left ventricular (LV) systolic dysfunction have not been extensively investigated. Eighty-four patients with DMD (aged 18.6 +/- 4.8 years) underwent standard and signal-averaged electrocardiography, 24-hour Holter monitoring, and echocardiography. The prevalence of electrocardiographic abnormalities, frequent ventricular premature complexes, LPs, and LV systolic dysfunction was 71%, 32%, 28%, and 35%, respectively. Median follow-up was 76 months (range 5 to 106). The mortality rate in the follow-up period was 27%. The typical DMD electrocardiographic alterations, ventricular arrhythmic pattern, and LPs were not predictors of mortality. In contrast, the presence of LV systolic dysfunction detected on echocardiography was a powerful predictor of mortality in the follow-up period (p = 0.013, hazard ratio 3.14, 95% confidence interval 1.27 to 7.79). Thus, echocardiographic assessment of LV systolic dysfunction provides prognostic information in patients with DMD. Electrocardiographic alterations, ventricular arrhythmias, and LPs have no prognostic value in predicting mortality in these patients.
- Published
- 2002
- Full Text
- View/download PDF
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