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INMOST is a software platform for the development of parallel numerical models on general polyhedral grids. In this paper we present the INMOST platform as the powerful tool for numerical modelling. The place of INMOST platform among other modern widespread libraries and numerical modelling packages is shown. A brief overview of tools that help in implementation of each stage of mathematical modelling is presented. Examples of INMOST application demonstrate appealing features of INMOST-based numerical modelling. [ABSTRACT FROM AUTHOR]

Platelets upregulate the generation of thrombin and reinforce the fibrin clot which increases the incidence risk of venous thromboembolism (VTE). However, the role of platelets in the pathogenesis of venous cardiovascular diseases remains hard to quantify. An experimentally validated model of thrombin generation dynamics is formulated. The model predicts that a high platelet count increases the peak value of generated thrombin as well as the endogenous thrombin potential (ETP) as reported in experimental data. To investigate the effects of platelets density, shear rate, and wound size on the initiation of blood coagulation, we calibrate a previously developed model of venous thrombus formation and implement it in 3D using a novel cell-centered finite-volume solver. We conduct numerical simulations to reproduce in vitro experiments of blood coagulation in microfluidic capillaries. Then, we derive a reduced one-equation model of thrombin distribution from the previous model under simplifying hypotheses and we use it to determine the conditions of clotting initiation on the platelet count, the shear rate, and the plasma composition. The initiation of clotting also exhibits a threshold response to the size of the wounded region in good agreement with the reported experimental findings., Competing Interests: The authors have declared that no competing interests exist.