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1. CHEK2 is a multiorgan cancer susceptibility gene

Author

Cybulski, C., Gorski, B., Huzarski, T., Masojc, B., Mierzejewski, M., Debniak, T., Teodorczyk, U., Byrski, T., Gronwald, J., Matyjasik, J., Zlowocka, E., Lenner, M., Grabowska, E., Nej, K., Castaneda, J., Medrek, K., Szymanska, A., Szymanska, J., Kurzawski, G., Suchy, J., Oszurek, O., Witek, A., Narod, S.A., and Lubinski, J.

Subjects
Prostate cancer -- Research, Breast cancer -- Research, Biological sciences
Published
2004

2. Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility

Author

Weren, R.D.A. (Robbert D. A.), Van Der Post, R.S. (Rachel S.), Vogelaar, I.P. (Ingrid P.), Van Krieken, J.H. (J. Han), Spruijt, L. (Liesbeth), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Aalfs, C.M. (Cora), Hest, L.P. (Liselotte) van, Oliveira, C. (Carla), Kamping, E. (Eveline), Schackert, H.K. (Hans), Ranzani, G.N. (Guglielmina N.), Gómez García, E.B. (Encarna), Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Cats, A. (Annemieke), Bjørnevoll, I. (Inga), Hoogerbrugge, N. (Nicoline), Ligtenberg, M.J. (Marjolijn), Weren, R.D.A. (Robbert D. A.), Van Der Post, R.S. (Rachel S.), Vogelaar, I.P. (Ingrid P.), Van Krieken, J.H. (J. Han), Spruijt, L. (Liesbeth), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Aalfs, C.M. (Cora), Hest, L.P. (Liselotte) van, Oliveira, C. (Carla), Kamping, E. (Eveline), Schackert, H.K. (Hans), Ranzani, G.N. (Guglielmina N.), Gómez García, E.B. (Encarna), Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Cats, A. (Annemieke), Bjørnevoll, I. (Inga), Hoogerbrugge, N. (Nicoline), and Ligtenberg, M.J. (Marjolijn)

Abstract

Background: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. Methods: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes. Results: Predicted deleterious germline variants were not encountered in MYD88, but recurrently observed in CTNNA1 (n=2) and MAP3K6 (n=3) in our cohort of patients with GC. In contrast to deleterious variants in CTNNA1, deleterious variants in MAP3K6 also occur frequently in the general population. Conclusions: Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified.

Published
2018
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3. Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility

Author

Weren, R.D.A., Post, R.S. van der, Vogelaar, I.P., Krieken, J.H.J.M. van, Spruijt, L., Lubinski, J., Jakubowska, A., Teodorczyk, U., Aalfs, C.M., Hest, L.P. van, Oliveira, C. de, Kamping, E.J., Schackert, H.K., Ranzani, G.N., Garcia, E.B., Hes, F.J., Holinski-Feder, E., Genuardi, M., Ausems, M.G.E.M., Sijmons, R.H., Wagner, A., Kolk, L.E. van der, Cats, A., Bjornevoll, I., Hoogerbrugge, N., Ligtenberg, M.J.L., Weren, R.D.A., Post, R.S. van der, Vogelaar, I.P., Krieken, J.H.J.M. van, Spruijt, L., Lubinski, J., Jakubowska, A., Teodorczyk, U., Aalfs, C.M., Hest, L.P. van, Oliveira, C. de, Kamping, E.J., Schackert, H.K., Ranzani, G.N., Garcia, E.B., Hes, F.J., Holinski-Feder, E., Genuardi, M., Ausems, M.G.E.M., Sijmons, R.H., Wagner, A., Kolk, L.E. van der, Cats, A., Bjornevoll, I., Hoogerbrugge, N., and Ligtenberg, M.J.L.

Abstract

Contains fulltext : 196812.pdf (publisher's version ) (Open Access), BACKGROUND: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. METHODS: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes. RESULTS: Predicted deleterious germline variants were not encountered in MYD88, but recurrently observed in CTNNA1 (n=2) and MAP3K6 (n=3) in our cohort of patients with GC. In contrast to deleterious variants in CTNNA1, deleterious variants in MAP3K6 also occur frequently in the general population. CONCLUSIONS: Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified.

Published
2018

4. Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility

Author

Weren, RDA, van der Post, RS, Vogelaar, IP, Van Krieken, JH, Spruijt, L, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, CM, Hest, LP, Oliveira, C, Kamping, EJ, Schackert, HK, Ranzani, GN, Garcia, EBG, Hes, FJ, Holinski-Feder, E, Genuardi, M, Ausems, M, Sijmons, RH, Wagner, Anja, van der Kolk, LE, Cats, A, Bjornevoll, I, Hoogerbrugge, N, Ligtenberg, MJL, Weren, RDA, van der Post, RS, Vogelaar, IP, Van Krieken, JH, Spruijt, L, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, CM, Hest, LP, Oliveira, C, Kamping, EJ, Schackert, HK, Ranzani, GN, Garcia, EBG, Hes, FJ, Holinski-Feder, E, Genuardi, M, Ausems, M, Sijmons, RH, Wagner, Anja, van der Kolk, LE, Cats, A, Bjornevoll, I, Hoogerbrugge, N, and Ligtenberg, MJL

Published
2018

5. Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing

Author

Vogelaar, I.P., Post, R.S. van der, Krieken, J.H. van, Spruijt, L., Zelst-Stams, W.A.G. van, Kets, C.M., Lubinski, J., Jakubowska, A., Teodorczyk, U., Aalfs, C.M., Hest, L.P. van, Pinheiro, H., Oliveira, C. de, Jhangiani, S.N., Muzny, D.M., Gibbs, R.A., Lupski, J.R., Ligt, J. de, Vissers, L.E.L.M., Hoischen, A., Gilissen, C., Vorst, J.M. van de, Goeman, J.J., Schackert, H.K., Ranzani, G.N., Molinaro, V., Garcia, E.B., Hes, F.J., Holinski-Feder, E., Genuardi, M., Ausems, M., Sijmons, R.H., Wagner, A., Kolk, L.E. van der, Bjornevoll, I., Hoberg-Vetti, H., Geurts van Kessel, A.H.M., Kuiper, R.P., Ligtenberg, M.J.L., Hoogerbrugge, N., Vogelaar, I.P., Post, R.S. van der, Krieken, J.H. van, Spruijt, L., Zelst-Stams, W.A.G. van, Kets, C.M., Lubinski, J., Jakubowska, A., Teodorczyk, U., Aalfs, C.M., Hest, L.P. van, Pinheiro, H., Oliveira, C. de, Jhangiani, S.N., Muzny, D.M., Gibbs, R.A., Lupski, J.R., Ligt, J. de, Vissers, L.E.L.M., Hoischen, A., Gilissen, C., Vorst, J.M. van de, Goeman, J.J., Schackert, H.K., Ranzani, G.N., Molinaro, V., Garcia, E.B., Hes, F.J., Holinski-Feder, E., Genuardi, M., Ausems, M., Sijmons, R.H., Wagner, A., Kolk, L.E. van der, Bjornevoll, I., Hoberg-Vetti, H., Geurts van Kessel, A.H.M., Kuiper, R.P., Ligtenberg, M.J.L., and Hoogerbrugge, N.

Abstract

Contains fulltext : 182216.pdf (publisher's version ) (Open Access), Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type GC to identify novel GC-predisposing candidate genes. As young age at diagnosis and familial clustering are hallmarks of genetic tumor susceptibility, we selected patients that were diagnosed below the age of 35, patients from families with two cases of GC at or below age 60 and patients from families with three GC cases at or below age 70. All included individuals were tested negative for germline CDH1 mutations before or during the study. Variants that were possibly deleterious according to in silico predictions were filtered using several independent approaches that were based on gene function and gene mutation burden in controls. Despite a rigorous search, no obvious candidate GC predisposition genes were identified. This negative result stresses the importance of future research studies in large, homogeneous cohorts.

Published
2017

6. Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing

Author

Vogelaar, I.P. (Ingrid P.), Van Der Post, R.S. (Rachel S.), Van Krieken, J.H. (J. Han), Spruijt, L. (Liesbeth), Zelst-Stams, W.A. van, Kets, C.M. (Marleen), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Aalfs, C.M. (Cora), Hest, L.P. (Liselotte) van, Pinheiro, H. (Hugo), Oliveira, C. (Carla), Jhangiani, S.N. (Shalini N.), Muzny, D. (Donna), Gibbs, R.A. (Richard A.), Lupski, J.R. (James R.), Ligt, J. (Joep) de, Vissers, L.E.L.M., Hoischen, A. (Alex), Gilissen, C. (Christian), Van De Vorst, M. (Maartje), Goeman, J.J. (Jelle), Schackert, H.K. (Hans), Ranzani, G.N. (Guglielmina N.), Molinaro, V. (Valeria), Garcia, E.B.G., Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Bjørnevoll, I. (Inga), Høberg Vetti, H. (Hildegunn), Geurts van Kessel, A.H.M. (Ad), Kuiper, R. (Ruud), Ligtenberg, M.J. (Marjolijn), Hoogerbrugge, N. (Nicoline), Vogelaar, I.P. (Ingrid P.), Van Der Post, R.S. (Rachel S.), Van Krieken, J.H. (J. Han), Spruijt, L. (Liesbeth), Zelst-Stams, W.A. van, Kets, C.M. (Marleen), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Aalfs, C.M. (Cora), Hest, L.P. (Liselotte) van, Pinheiro, H. (Hugo), Oliveira, C. (Carla), Jhangiani, S.N. (Shalini N.), Muzny, D. (Donna), Gibbs, R.A. (Richard A.), Lupski, J.R. (James R.), Ligt, J. (Joep) de, Vissers, L.E.L.M., Hoischen, A. (Alex), Gilissen, C. (Christian), Van De Vorst, M. (Maartje), Goeman, J.J. (Jelle), Schackert, H.K. (Hans), Ranzani, G.N. (Guglielmina N.), Molinaro, V. (Valeria), Garcia, E.B.G., Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Bjørnevoll, I. (Inga), Høberg Vetti, H. (Hildegunn), Geurts van Kessel, A.H.M. (Ad), Kuiper, R. (Ruud), Ligtenberg, M.J. (Marjolijn), and Hoogerbrugge, N. (Nicoline)

Abstract

Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type GC to identify novel GC-predisposing candidate genes. As young age at diagnosis and familial clustering are hallmarks of genetic tumor susceptibility, we selected patients that were diagnosed below the age of 35, patients from families with two cases of GC at or below age 60 and patients from families with three GC cases at or below age 70. All included individuals were tested negative for germline CDH1 mutations before or during the study. Variants that were possibly deleterious according to in silico predictions were filtered using several independent approaches that were based on gene function and gene mutation burden in controls. Despite a rigorous search, no obvious candidate GC predisposition genes were identified. This negative result stresses the importance of future research studies in large, homogeneous cohorts.

Published
2017
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7. Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88

Author

Ligtenberg, Mj, van der Post, R, de Voer, Rm, Kets, Cm, Jansen, Tj, Jacobs, L, Schreibelt, G, International Gastric Cancer Genetics Group (Lubinski, J, Jakubowska, A, Teodorczyk, U, Schackert, Hk, Aalfs, Cm, Genuardi, Maurizio, Gómez García, Eb, Ranzani, Gn, Molinaro, V, van Hest, Lp, Hes, Fj, Holinski-Feder, E, Ausems, Mg, Sijmons, Rh, Wagner, A, van der Kolk, Le, Pinheiro, H, Oliveira, C, Bjørnevoll, I, Vetti, Hh, van Krieken, J, ), De, Vrie, Ij, Netea, Mg, Hoogerbrugge, N, Genuardi M. (ORCID:0000-0002-7410-8351), Ligtenberg, Mj, van der Post, R, de Voer, Rm, Kets, Cm, Jansen, Tj, Jacobs, L, Schreibelt, G, International Gastric Cancer Genetics Group (Lubinski, J, Jakubowska, A, Teodorczyk, U, Schackert, Hk, Aalfs, Cm, Genuardi, Maurizio, Gómez García, Eb, Ranzani, Gn, Molinaro, V, van Hest, Lp, Hes, Fj, Holinski-Feder, E, Ausems, Mg, Sijmons, Rh, Wagner, A, van der Kolk, Le, Pinheiro, H, Oliveira, C, Bjørnevoll, I, Vetti, Hh, van Krieken, J, ), De, Vrie, Ij, Netea, Mg, Hoogerbrugge, N, and Genuardi M. (ORCID:0000-0002-7410-8351)

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

Published
2017

8. Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing

Author

Vogelaar, IP, van der Post, RS, van Krieken, J, Spruijt, L, van Zelst-Stams, W A G, Kets, CM, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, CM, van Hest, LP (Liselotte), Pinheiro, H, Oliveira, C, Jhangiani, SN, Muzny, DM, Gibbs, RA, Lupski, JR, de Ligt, J, Vissers, L, Hoischen, A, Gilissen, C, van de Vorst, M, Goeman, JJ, Schackert, HK, Ranzani, GN, Molinaro, V, Garcia, EBG, Hes, FJ, Holinski-Feder, E, Genuardi, M, Ausems, M, Sijmons, RH, Wagner, Anja, van der Kolk, LE, Bjornevoll, I, Hoberg-Vetti, H, van Kessel, AG, Kuiper, RP (Roland), Ligtenberg, MJL, Hoogerbrugge, N, Vogelaar, IP, van der Post, RS, van Krieken, J, Spruijt, L, van Zelst-Stams, W A G, Kets, CM, Lubinski, J, Jakubowska, A, Teodorczyk, U, Aalfs, CM, van Hest, LP (Liselotte), Pinheiro, H, Oliveira, C, Jhangiani, SN, Muzny, DM, Gibbs, RA, Lupski, JR, de Ligt, J, Vissers, L, Hoischen, A, Gilissen, C, van de Vorst, M, Goeman, JJ, Schackert, HK, Ranzani, GN, Molinaro, V, Garcia, EBG, Hes, FJ, Holinski-Feder, E, Genuardi, M, Ausems, M, Sijmons, RH, Wagner, Anja, van der Kolk, LE, Bjornevoll, I, Hoberg-Vetti, H, van Kessel, AG, Kuiper, RP (Roland), Ligtenberg, MJL, and Hoogerbrugge, N

Published
2017

9. Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect

Author

Vogelaar, I.P. (Ingrid P.), Ligtenberg, M.J. (Marjolijn), Van Der Post, R.S. (Rachel S.), de Voer, R.M. (Richarda M.), Kets, C.M. (Marleen), Jansen, T.J.G. (Trees J. G.), Jacobs, L. (Liesbeth), Schreibelt, G. (Gerty), Vries, I.J.M. (Jolanda) de, Netea, M.G. (Mihai), Hoogerbrugge, N. (Nicoline), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Schackert, H.K. (Hans), Aalfs, C.M. (Cora), Gómez García, E.B. (Encarna), Ranzani, G.N. (Guglielmina N.), Molinaro, V. (Valeria), Hest, L.P. (Liselotte) van, Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Pinheiro, H. (Hugo), Oliveira, C. (Carla), Bjørnevoll, I. (Inga), Høberg Vetti, H. (Hildegunn), Han, J., van Krieken, J.M., Vogelaar, I.P. (Ingrid P.), Ligtenberg, M.J. (Marjolijn), Van Der Post, R.S. (Rachel S.), de Voer, R.M. (Richarda M.), Kets, C.M. (Marleen), Jansen, T.J.G. (Trees J. G.), Jacobs, L. (Liesbeth), Schreibelt, G. (Gerty), Vries, I.J.M. (Jolanda) de, Netea, M.G. (Mihai), Hoogerbrugge, N. (Nicoline), Lubinski, J. (Jan), Jakubowska, A. (Anna), Teodorczyk, U. (Urszula), Schackert, H.K. (Hans), Aalfs, C.M. (Cora), Gómez García, E.B. (Encarna), Ranzani, G.N. (Guglielmina N.), Molinaro, V. (Valeria), Hest, L.P. (Liselotte) van, Hes, F.J. (Frederik), Holinski-Feder, E. (Elke), Genuardi, M. (Maurizio), Ausems, M.G.E.M. (Margreet), Sijmons, R.H. (Rolf), Wagner, A. (Anja), Kolk, L.E. (Lizet) van der, Pinheiro, H. (Hugo), Oliveira, C. (Carla), Bjørnevoll, I. (Inga), Høberg Vetti, H. (Hildegunn), Han, J., and van Krieken, J.M.

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

Published
2016
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11. Role of germline aberrations affecting CTNNA1 , MAP3K6 and MYD88 in gastric cancer susceptibility.

Author

Weren RDA, van der Post RS, Vogelaar IP, van Krieken JH, Spruijt L, Lubinski J, Jakubowska A, Teodorczyk U, Aalfs CM, van Hest LP, Oliveira C, Kamping EJ, Schackert HK, Ranzani GN, Gómez García EB, Hes FJ, Holinski-Feder E, Genuardi M, Ausems MGEM, Sijmons RH, Wagner A, van der Kolk LE, Cats A, Bjørnevoll I, Hoogerbrugge N, and Ligtenberg MJL

Subjects
Adult, Aged, Cohort Studies, Europe, Female, Genetic Predisposition to Disease, Germ-Line Mutation, High-Throughput Nucleotide Sequencing, Humans, Male, Middle Aged, Sequence Analysis, DNA, Young Adult, Antigens, CD genetics, Cadherins genetics, MAP Kinase Kinase Kinases genetics, Myeloid Differentiation Factor 88 genetics, Stomach Neoplasms genetics, alpha Catenin genetics
Abstract

Background: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1 , MAP3K6 or MYD88 ., Methods: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1 germline mutation for germline variants affecting CTNNA1 , MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes., Results: Predicted deleterious germline variants were not encountered in MYD88 , but recurrently observed in CTNNA1 (n=2) and MAP3K6 (n=3) in our cohort of patients with GC. In contrast to deleterious variants in CTNNA1 , deleterious variants in MAP3K6 also occur frequently in the general population., Conclusions: Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Published
2018
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12. Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing.

Author

Vogelaar IP, van der Post RS, van Krieken JHJ, Spruijt L, van Zelst-Stams WA, Kets CM, Lubinski J, Jakubowska A, Teodorczyk U, Aalfs CM, van Hest LP, Pinheiro H, Oliveira C, Jhangiani SN, Muzny DM, Gibbs RA, Lupski JR, de Ligt J, Vissers LELM, Hoischen A, Gilissen C, van de Vorst M, Goeman JJ, Schackert HK, Ranzani GN, Molinaro V, Gómez García EB, Hes FJ, Holinski-Feder E, Genuardi M, Ausems MGEM, Sijmons RH, Wagner A, van der Kolk LE, Bjørnevoll I, Høberg-Vetti H, van Kessel AG, Kuiper RP, Ligtenberg MJL, and Hoogerbrugge N

Subjects
Adult, Aged, Antigens, CD, Cadherins genetics, Early Detection of Cancer methods, Female, Humans, Male, Middle Aged, Sequence Analysis, DNA methods, Stomach Neoplasms diagnosis, Exome, Genetic Predisposition to Disease, Genetic Testing methods, Germ-Line Mutation, Stomach Neoplasms genetics
Abstract

Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type GC to identify novel GC-predisposing candidate genes. As young age at diagnosis and familial clustering are hallmarks of genetic tumor susceptibility, we selected patients that were diagnosed below the age of 35, patients from families with two cases of GC at or below age 60 and patients from families with three GC cases at or below age 70. All included individuals were tested negative for germline CDH1 mutations before or during the study. Variants that were possibly deleterious according to in silico predictions were filtered using several independent approaches that were based on gene function and gene mutation burden in controls. Despite a rigorous search, no obvious candidate GC predisposition genes were identified. This negative result stresses the importance of future research studies in large, homogeneous cohorts.

Published
2017
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13. The risk of gastric cancer in carriers of CHEK2 mutations.

Author

Teodorczyk U, Cybulski C, Wokołorczyk D, Jakubowska A, Starzyńska T, Lawniczak M, Domagała P, Ferenc K, Marlicz K, Banaszkiewicz Z, Wiśniowski R, Narod SA, and Lubiński J

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Genotype, Humans, Male, Middle Aged, Prognosis, Young Adult, Checkpoint Kinase 2 genetics, Genetic Predisposition to Disease, Heterozygote, Mutation genetics, Stomach Neoplasms genetics
Abstract

CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated with cancers at many sites, including breast and prostate cancers, but the relationship between CHEK2 and gastric cancer has not been extensively studied. In Poland, there are four known founder alleles of CHEK2; three alleles are protein truncating (1100delC, IVS2G>A, del5395) and the other is a missense variant (I157T). We examined the frequencies of four Polish founder mutations in the CHEK2 gene in 658 unselected gastric cancer patients, in 154 familial gastric cancer patients and in 8,302 controls. A CHEK2 mutation was seen in 57 of 658 (8.7 %) unselected patients with gastric cancer compared to 480 of 8,302 (5.8 %) controls (OR 1.6, p = 0.004). A CHEK2 mutation was present in 19 of 154 (12.3 %) familial cases (OR = 2.3, p = 0.001). The odds ratio for early onset (<50 years) gastric cancer was higher (2.1, p = 0.01), than for cases diagnosed at age of 50 or above (OR 1.4, p = 0.05). Truncating mutations of CHEK2 were associated with higher risk (OR = 2.1, p = 0.02) than the missense mutation I157T (OR = 1.4, p = 0.04). CHEK2 mutations predispose to gastric cancer, in particular to young-onset cases.

Published
2013
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14. A range of cancers is associated with the rs6983267 marker on chromosome 8.

Author

Wokolorczyk D, Gliniewicz B, Sikorski A, Zlowocka E, Masojc B, Debniak T, Matyjasik J, Mierzejewski M, Medrek K, Oszutowska D, Suchy J, Gronwald J, Teodorczyk U, Huzarski T, Byrski T, Jakubowska A, Górski B, van de Wetering T, Walczak S, Narod SA, Lubinski J, and Cybulski C

Subjects
Adult, Aged, Aged, 80 and over, Female, Genetic Markers genetics, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult, Chromosomes, Human, Pair 8, Neoplasms genetics
Abstract

Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker. To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls. A significant odds ratio (OR) was observed for prostate cancer for carriers of genotype GG [OR, 1.77; 95% confidence interval (CI), 1.47-2.13]. The homozygote OR was higher for tumors with Gleason score 8 to 10 (OR, 1.94; 95% CI, 1.18-3.20) than for tumors with Gleason score 7 and below (OR, 1.65; 95% CI, 1.31-2.08). Significantly elevated (homozygote) ORs were observed for 4 other cancer sites, including colon (OR, 1.36; 95% CI, 1.08-1.72), kidney (OR, 1.52; 95% CI, 1.12-2.05), thyroid (OR, 1.37; 95% CI, 1.02-1.82), and larynx (OR, 1.39; 95% CI, 1.02-1.90). Information was available on family histories of cancer for eight sites. For six of the eight sites (prostate, breast, bladder, larynx, lung, and kidney), the homozygote ORs were higher for cases with a positive family history (at least one first-degree with any cancer) than for cases with unaffected first-degree relatives. Our results suggest that the range of cancers associated with the rs6983267 marker might be larger than previously thought.

Published
2008
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15. CDKN2A common variant and multi-organ cancer risk--a population-based study.

Author

Debniak T, Scott RJ, Huzarski T, Byrski T, Rozmiarek A, Debniak B, Górski B, Cybulski C, Medrek K, Mierzejewski M, Masojc B, Matyjasik J, Złowocka E, Teodorczyk U, Lener M, Klujszo-Grabowska E, Nej-Wołosiak K, Jaworowska E, Oszutowska D, Szymańska A, Szymańska J, Castaneda J, van de Wetering T, Suchy J, Kurzawski G, Oszurek O, Narod S, and Lubinski J

Subjects
Adult, Aged, Alanine, Colorectal Neoplasms epidemiology, Colorectal Neoplasms genetics, Female, Genetic Variation, Humans, Lung Neoplasms epidemiology, Lung Neoplasms genetics, Male, Middle Aged, Odds Ratio, Poland epidemiology, Prevalence, Risk Assessment, Risk Factors, Threonine, Cyclin-Dependent Kinase Inhibitor p16 genetics, Genes, p16, Neoplasms epidemiology, Neoplasms genetics
Abstract

The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi-organ cancer risk in the Polish population., (Copyright 2006 Wiley-Liss, Inc.)

Published
2006
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16. Low-risk Genes and Multi-organ Cancer Risk in the Polish Population.

Author

Debniak T, Cybulski C, Kurzawski G, Górski B, Huzarski T, Byrski T, Gronwald J, Suchy J, Masojć B, Mierzejewski M, Lener M, Teodorczyk U, Medrek K, Złowocka E, Grabowska-Kłujszo E, Nej-Wołosiak K, Szymańska A, Szymańska-Pasternak J, Matyjasik J, Wetering Tv, Jakubowska A, Oszurek O, Tołoczko-Grabarek A, Castaneda J, Scott R, Narod SA, and Lubiński J

Published
2006
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17. The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs.

Author

Lubiński J, Huzarski T, Kurzawski G, Suchy J, Masojć B, Mierzejewski M, Lener M, Domagała W, Chosia M, Teodorczyk U, Medrek K, Debniak T, Złowocka E, Gronwald J, Byrski T, Grabowska E, Nej K, Szymańska A, Szymańska J, Matyjasik J, Cybulski C, Jakubowska A, Górski B, and Narod SA

Abstract

The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.

Published
2005
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