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1. Measurement of $J/\psi$ and $\psi\left(2S\right)$ production in $p+p$ and $p+d$ interactions at 120 GeV

Author

Leung, C. H., Nagai, K., Nakano, K., Nawarathne, D., Dove, J., Prasad, S., Wuerfel, N., Aidala, C. A., Arrington, J., Ayuso, C., Barker, C. L., Brown, C. N., Chang, W. C., Chen, A., Christian, D. C., Dannowitz, B. P., Daugherity, M., Fassi, L. El, Geesaman, D. F., Gilman, R., Goto, Y., Guo, R., Hague, T. J., Holt, R. J., Hossain, M. F., Isenhower, D., Kinney, E., Klein, A., Kleinjan, D. W., Kudo, Y., Lin, P. -J., Liu, K., Liu, M. X., Lorenzon, W., McClellan, R. E., McGaughey, P. L., Medeiros, M. M., Miyachi, Y., Miyasaka, S., Morton, D. H., Nakahara, K., Nara, S., Pate, S. F., Peng, J. C., Pun, A., Ramson, B. J., Reimer, P. E., Rubin, J. G., Sanftl, F., Sawada, S., Sawada, T., Scott, M. B. C., Shibata, T. -A., Tadepalli, A. S., Teo, M., Towell, R. S., Uemura, S., Wang, S. G., Wickes, A. B., Wu, J., and Ye, Z. H.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We report the $p+p$ and $p+d$ differential cross sections measured in the SeaQuest experiment for $J/\psi$ and $\psi\left(2S\right)$ production at 120 GeV beam energy covering the forward $x$-Feynman ($x_F$) range of $0.5 < x_F <0.9$. The measured cross sections are in good agreement with theoretical calculations based on the nonrelativistic QCD (NRQCD) using the long-distance matrix elements deduced from a recent global analysis of proton- and pion-induced charmonium production data. The $\sigma_{\psi\left(2S\right)} / \sigma_{J/\psi}$ cross section ratios are found to increase as $x_F$ increases, indicating that the $q \bar{q}$ annihilation process has larger contributions in the $\psi\left(2S\right)$ production than the $J/\psi$ production. The $\sigma_{pd}/2\sigma_{pp}$ cross section ratios are observed to be significantly different for the Drell-Yan process and $J/\psi$ production, reflecting their different production mechanisms. We find that the $\sigma_{pd}/2\sigma_{pp}$ ratios for $J/\psi$ production at the forward $x_F$ region are sensitive to the $\bar{d}/ \bar{u}$ flavor asymmetry of the proton sea, analogous to the Drell-Yan process. The transverse momentum ($p_T$) distributions for $J/\psi$ and $\psi\left(2S\right)$ production are also presented and compared with data collected at higher center-of-mass energies., Comment: 8 pages, 7 figures, with 1 page of supplementary material which has 2 figures

Published
2024
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2. LIPASE IMMOBILIZATION ON FIBERS GRAFTED WITH POLYGLYCIDYL METHACHRYLATE

Author

Maan Alkhatib, Nik Adlin Bahrudin, HAMZAH M. SALLEH, Mohamed M. E. Nasef, and Teo M. Ting

Subjects
immobilization, enzyme, lipase, optimization, fcccd, rsm, fibers, nylon, stability, reusability, kinetics study, Engineering (General). Civil engineering (General), TA1-2040
Abstract

ABSTRACT: Lipase enzyme originated from wheat germ was immobilized on nylon -6- grafted with polyglycidyl methachrylate (PGMA). The immobilization of enzyme experiments were designed and studied using face centred central composite design (FCCCD) under response surface methodology (RSM). Prior to immobilization, the polymer was activated with diethyl amine/ethanol to introduce an amine functional group to facilitate covalent bonding with the enzyme. The immobilized and free enzymes were characterized for effect of temperature and pH on enzyme activity, stability, storage and reusability as well as kinetics studies. ANOVA revealed that optimum lipase activity of 0.287 U/ml was achieved at immobilization time of 5 h, pH of 6 and 1.0 mg/ml for enzyme concentration. The optimum temperatures and pH for immobilized and free enzymes were 45 °C and 35 °C, and 8 and 7, respectively. The immobilized enzyme showed higher stability compared to free enzyme. The immobilized enzyme retained 18% of its activity after being recycled 8 times. In a storage stability test, immobilized lipase was able to retain 70% of its activity after being stored for 30 days, while free enzyme activity dropped to 15 % after 20 days of storage. ABSTRAK:Enzim Lipase telah dihasilkan daripada mikroorganisma pegun gandum di atas nilon -6- dan digraf bersama poliglisidel methakrilet (PGMA). Enzim pegun ini direka dan dikaji secara eksperimen menggunakan reka bentuk campuran pusat pada permukaan (FCCCD) di bawah kaedah tindak balas permukaan (RSM). Sebelum menjadi pegun, polimer ini telah diaktifkan dengan dietil amine/ethanol bagi menghasilkan kumpulan fungsi amine bagi membantu ikatan kovalen atom pada enzim. Enzim pegun dan bebas ini telah dikategorikan mengikut kesan enzim ke atas suhu, aktiviti enzim ke atas kesan pH, kestabilan, keboleh-simpanan dan keboleh-gunaan balik, serta ujian tindak balas kinetik. ANOVA membuktikan bahawa aktiviti optimum enzim lipase ini adalah sebanyak 0.287 U/ml telah terhasil selama 5 jam pegun, pada pH 6 dan kepekatan enzim sebanyak 1.0 mg/ml. Suhu dan pH optimum, pada enzim pegun dan enzim bebas ini adalah pada 45 °C dan 35 °C, dan pH 8 dan 7, masing-masing. Enzim pegun ini menunjukkan lebih stabil daripada enzim bebas. Enzim pegun dilihat kekal 18% daripada aktivitinya selepas 8 kali ulangan. Melalui ujian kestabilan simpanan, enzim lipase pegun dapat mengekalkan 70% daripada aktivinya selepas disimpan selama 30 hari, manakala aktiviti enzim bebas telah menurun kepada 15% selepas 20 hari dalam simpanan.

Published
2019
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3. Measurement of flavor asymmetry of the light-quark sea in the proton with Drell-Yan dimuon production in p+p and p+d collisions at 120 GeV

Author

Dove, J, Kerns, B, Leung, C, McClellan, RE, Miyasaka, S, Morton, DH, Nagai, K, Prasad, S, Sanftl, F, Scott, MBC, Tadepalli, AS, Aidala, CA, Arrington, J, Ayuso, C, Barker, CT, Brown, CN, Chang, TH, Chang, WC, Chen, A, Christian, DC, Dannowitz, BP, Daugherity, M, Diefenthaler, M, Fassi, L El, Geesaman, DF, Gilman, R, Goto, Y, Guo, L, Guo, R, Hague, TJ, Holt, RJ, Isenhower, D, Kinney, ER, Kitts, ND, Klein, A, Kleinjan, DW, Kudo, Y, Lin, P-J, Liu, K, Liu, MX, Lorenzon, W, Makins, NCR, de Medeiros, M Mesquita, McGaughey, PL, Miyachi, Y, Mooney, I, Nakahara, K, Nakano, K, Nara, S, Peng, JC, Puckett, AJ, Ramson, BJ, Reimer, PE, Rubin, JG, Sawada, S, Sawada, T, Shibata, T-A, Shiu, SH, Su, D, Teo, M, Tice, BG, Towell, RS, Uemura, S, Watson, TS, Wang, SG, Wickes, AB, Wu, J, Xi, Z, and Ye, Z

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics
Abstract

Evidence for a flavor asymmetry between the ū and d¯ quark distributions in the proton has been found in deep-inelastic scattering and Drell-Yan experiments. The pronounced dependence of this flavor asymmetry on x (fraction of nucleon momentum carried by partons) observed in the Fermilab E866 Drell-Yan experiment suggested a drop of the d¯(x)/ū(x) ratio in the x>0.15 region. We report results from the SeaQuest Fermilab E906 experiment with improved statistical precision for d¯(x)/ū(x) in the large x region up to x=0.45 using the 120 GeV proton beam. Two different methods for extracting the Drell-Yan cross section ratios, σpd/2σpp, from the SeaQuest data give consistent results. The d¯(x)/ū(x) ratios and the d¯(x)-ū(x) differences are deduced from these cross section ratios for 0.13

Published
2023

4. Measurement of flavor asymmetry of light-quark sea in the proton with Drell-Yan dimuon production in $p+p$ and $p+d$ collisions at 120 GeV

Author

Dove, J., Kerns, B., Leung, C., McClellan, R. E., Miyasaka, S., Morton, D. H., Nagai, K., Prasad, S., Sanftl, F., Scott, M. B. C., Tadepalli, A. S., Aidala, C. A., Arrington, J., Ayuso, C., Barker, C. T., Brown, C. N., Chang, T. H., Chang, W. C., Chen, A., Christian, D. C., Dannowitz, B. P., Daugherity, M., Diefenthaler, M., Fassi, L. El, Geesaman, D. F., Gilman, R., Goto, Y., Guo, L., Guo, R., Hague, T. J., Holt, R. J., Isenhower, D., Kinney, E. R., Kitts, N. D., Klein, A., Kleinjan, D. W., Kudo, Y., Lin, P. -J., Liu, K., Liu, M. X., Lorenzon, W., Makins, N. C. R., de Medeiros, M. Mesquita, McGaughey, P. L., Miyachi, Y., Mooney, I., Nakahara, K., Nakano, K., Nara, S., Peng, J. C., Puckett, A. J., Ramson, B. J., Reimer, P. E., Rubin, J. G., Sawada, S., Sawada, T., Shibata, T. -A., Shiu, S. H., Su, D., Teo, M., Tice, B. G, Towell, R. S., Uemura, S., Watson, T. S., Wang, S. G., Wickes, A. B., Wu, J., Xi, Z., and Ye, Z.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Evidence for a flavor asymmetry between the $\bar u$ and $\bar d$ quark distributions in the proton has been found in deep-inelastic scattering and Drell-Yan experiments. The pronounced dependence of this flavor asymmetry on $x$ (fraction of nucleon momentum carried by partons) observed in the Fermilab E866 Drell-Yan experiment suggested a drop of the $\bar d\left(x\right) / \bar u\left(x\right)$ ratio in the $x > 0.15$ region. We report results from the SeaQuest Fermilab E906 experiment with improved statistical precision for $\bar d\left(x\right) / \bar u\left(x\right)$ in the large $x$ region up to $x=0.45$ using the 120 GeV proton beam. Two different methods for extracting the Drell-Yan cross section ratios, $\sigma^{pd} /2 \sigma^{pp}$, from the SeaQuest data give consistent results. The $\bar{d}\left(x\right) / \bar{u}\left(x\right)$ ratios and the $\bar d\left(x\right) - \bar u\left(x\right)$ differences are deduced from these cross section ratios for $0.13 < x < 0.45$. The SeaQuest and E866/NuSea $\bar{d}\left(x\right) / \bar{u}\left(x\right)$ ratios are in good agreement for the $x\lesssim 0.25$ region. The new SeaQuest data, however, show that $\bar d\left(x\right)$ continues to be greater than $\bar u\left(x\right)$ up to the highest $x$ value ($x = 0.45$). The new results on $\bar{d}\left(x\right) / \bar{u}\left(x\right)$ and $\bar{d}\left(x\right) - \bar{u}\left(x\right)$ are compared with various parton distribution functions and theoretical calculations.

Published
2022

5. Publisher Correction: The asymmetry of antimatter in the proton.

Author

Dove, J, Kerns, B, McClellan, RE, Miyasaka, S, Morton, DH, Nagai, K, Prasad, S, Sanftl, F, Scott, MBC, Tadepalli, AS, Aidala, CA, Arrington, J, Ayuso, C, Barker, CL, Brown, CN, Chang, WC, Chen, A, Christian, DC, Dannowitz, BP, Daugherity, M, Diefenthaler, M, El Fassi, L, Geesaman, DF, Gilman, R, Goto, Y, Guo, L, Guo, R, Hague, TJ, Holt, RJ, Isenhower, D, Kinney, ER, Kitts, N, Klein, A, Kleinjan, DW, Kudo, Y, Leung, C, Lin, P-J, Liu, K, Liu, MX, Lorenzon, W, Makins, NCR, de Medeiros, M Mesquita, McGaughey, PL, Miyachi, Y, Mooney, I, Nakahara, K, Nakano, K, Nara, S, Peng, J-C, Puckett, AJ, Ramson, BJ, Reimer, PE, Rubin, JG, Sawada, S, Sawada, T, Shibata, T-A, Su, D, Teo, M, Tice, BG, Towell, RS, Uemura, S, Watson, S, Wang, SG, Wickes, AB, Wu, J, Xi, Z, and Ye, Z

Subjects
General Science & Technology
Abstract

In Fig. 1c of this Article, the x-axis scale was inadvertently duplicated from Fig. 1b. The original Article has been corrected online.

Published
2022

6. The Asymmetry of Antimatter in the Proton

Author

Dove, J., Kerns, B., McClellan, R. E., Miyasaka, S., Morton, D. H., Nagai, K., Prasad, S., Sanftl, F., Scott, M. B. C., Tadepalli, A. S., Aidala, C. A., Arrington, J., Ayuso, C., Barker, C. L., Brown, C. N., Chang, W. C., Chen, A., Christian, D. C., Dannowitz, B. P., Daugherity, M., Diefenthaler, M., Fassi, L. El, Geesaman, D. F., Gilman, R., Goto, Y., Guo, L., Guo, R., Hague, T. J., Holt, R. J., Isenhower, D., Kinney, E. R., Kitts, N., Klein, A., Kleinjan, D. W., Kudo, Y., Leung, C., Lin, P. -J., Liu, K., Liu, M. X., Lorenzon, W., Makins, N. C. R., de Medeiros, M. Mesquita, McGaughey, P. L., Miyachi, Y., Mooney, I., Nakahara, K., Nakano, K., Nara, S., Peng, J. -C., Puckett, A. J., Ramson, B. J., Reimer, P. E., Rubin, J. G., Sawada, S., Sawada, T., Shibata, T. -A., Su, D., Teo, M., Tice, B. G, Towell, R. S., Uemura, S., Watson, S., Wang, S. G., Wickes, A. B., Wu, J., Xi, Z., and Ye, Z.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The fundamental building blocks of the proton, quarks and gluons, have been known for decades. However, we still have an incomplete theoretical and experimental understanding of how these particles and their dynamics give rise to the quantum bound state of the proton and its physical properties, such as for example its spin. The two up and the single down quarks that comprise the proton in the simplest picture account only for a few percent of the proton mass, the bulk of which is in the form of quark kinetic and potential energy and gluon energy from the strong force. An essential feature of this force, as described by quantum chromodynamics, is its ability to create matter-antimatter quark pairs inside the proton that exist only for a very short time. Their fleeting existence makes the antimatter quarks within protons difficult to study, but their existence is discernible in reactions where a matter-antimatter quark pair annihilates. In this picture of quark-antiquark creation by the strong force, the probability distributions as a function of momentum for the presence of up and down antimatter quarks should be nearly identical, since their masses are quite similar and small compared to the mass of the proton. In the present manuscript, we show evidence from muon pair production measurements that these distributions are significantly different, with more abundant down antimatter quarks than up antimatter quarks over a wide range of momentum. These results revive interest in several proposed mechanisms as the origin of this antimatter asymmetry in the proton that had been disfavored by the previous results and point to the future measurements that can distinguish between these mechanisms., Comment: 10 pages, 5 figures, 5 tables; Matches published version

Published
2021
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7. The asymmetry of antimatter in the proton

Author

Dove, J, Kerns, B, McClellan, RE, Miyasaka, S, Morton, DH, Nagai, K, Prasad, S, Sanftl, F, Scott, MBC, Tadepalli, AS, Aidala, CA, Arrington, J, Ayuso, C, Barker, CL, Brown, CN, Chang, WC, Chen, A, Christian, DC, Dannowitz, BP, Daugherity, M, Diefenthaler, M, El Fassi, L, Geesaman, DF, Gilman, R, Goto, Y, Guo, L, Guo, R, Hague, TJ, Holt, RJ, Isenhower, D, Kinney, ER, Kitts, N, Klein, A, Kleinjan, DW, Kudo, Y, Leung, C, Lin, P-J, Liu, K, Liu, MX, Lorenzon, W, Makins, NCR, de Medeiros, M Mesquita, McGaughey, PL, Miyachi, Y, Mooney, I, Nakahara, K, Nakano, K, Nara, S, Peng, J-C, Puckett, AJ, Ramson, BJ, Reimer, PE, Rubin, JG, Sawada, S, Sawada, T, Shibata, T-A, Su, D, Teo, M, Tice, BG, Towell, RS, Uemura, S, Watson, S, Wang, SG, Wickes, AB, Wu, J, Xi, Z, and Ye, Z

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Quantum Physics, Physical Sciences, General Science & Technology
Abstract

The fundamental building blocks of the proton-quarks and gluons-have been known for decades. However, we still have an incomplete theoretical and experimental understanding of how these particles and their dynamics give rise to the quantum bound state of the proton and its physical properties, such as its spin1. The two up quarks and the single down quark that comprise the proton in the simplest picture account only for a few per cent of the proton mass, the bulk of which is in the form of quark kinetic and potential energy and gluon energy from the strong force2. An essential feature of this force, as described by quantum chromodynamics, is its ability to create matter-antimatter quark pairs inside the proton that exist only for a very short time. Their fleeting existence makes the antimatter quarks within protons difficult to study, but their existence is discernible in reactions in which a matter-antimatter quark pair annihilates. In this picture of quark-antiquark creation by the strong force, the probability distributions as a function of momentum for the presence of up and down antimatter quarks should be nearly identical, given that their masses are very similar and small compared to the mass of the proton3. Here we provide evidence from muon pair production measurements that these distributions are considerably different, with more abundant down antimatter quarks than up antimatter quarks over a wide range of momenta. These results are expected to revive interest in several proposed mechanisms for the origin of this antimatter asymmetry in the proton that had been disfavoured by previous results4, and point to future measurements that can distinguish between these mechanisms.

Published
2021

8. The SeaQuest spectrometer at Fermilab

Author

Aidala, CA, Arrington, JR, Ayuso, C, Bowen, BM, Bowen, ML, Bowling, KL, Brown, AW, Brown, CN, Byrd, R, Carlisle, RE, Chang, T, Chang, WC, Chen, A, Chen, JY, Christian, DC, Chu, X, Dannowitz, BP, Daugherity, M, Diefenthaler, M, Dove, J, Durandet, C, El Fassi, L, Erdos, E, Fox, DM, Geesaman, DF, Gilman, R, Goto, Y, Guo, L, Guo, R, Hague, T, Hicks, CR, Holt, RJ, Isenhower, D, Jiang, X, Katich, JM, Kerns, BM, Kinney, ER, Kitts, ND, Klein, A, Kleinjan, D, Kras, J, Kudo, Y, Lin, PJ, Liu, D, Liu, K, Liu, MX, Lorenzon, W, Makins, NCR, Martinez, JD, McClellan, RE, McDonald, B, McGaughey, PL, McNease, SE, Medeiros, MM, Miller, B, Miller, AJ, Miyasaka, S, Miyachi, Y, Mooney, IA, Morton, DH, Nadim, B, Nagai, K, Nakahara, K, Nakano, K, Nara, S, Obata, S, Peng, JC, Prasad, S, Puckett, AJR, Ramson, BJ, Raymond, RS, Reimer, PE, Rubin, JG, Salinas, R, Sanftl, F, Sawada, S, Sawada, T, Scott, MBC, Selensky, LE, Shibata, TA, Shiu, S, Su, D, Tadepalli, AS, Teo, M, Tice, BG, Towell, CL, Towell, RS, Uemura, S, Wang, SG, Watson, S, White, N, Wickes, AB, Wood, MR, Wu, J, Xi, Z, Ye, Z, and Yin, Y

Subjects
SeaQuest, E906, Drell-Yan, Spectrometer, J/psi, Muon, physics.ins-det, nucl-ex, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract

The SeaQuest spectrometer at Fermilab was designed to detect oppositely-charged pairs of muons (dimuons) produced by interactions between a 120 GeV proton beam and liquid hydrogen, liquid deuterium and solid nuclear targets. The primary physics program uses the Drell–Yan process to probe antiquark distributions in the target nucleon. The spectrometer consists of a target system, two dipole magnets and four detector stations. The upstream magnet is a closed-aperture solid iron magnet which also serves as the beam dump, while the second magnet is an open aperture magnet. Each of the detector stations consists of scintillator hodoscopes and a high-resolution tracking device. The FPGA-based trigger compares the hodoscope signals to a set of pre-programmed roads to determine if the event contains oppositely-signed, high-mass muon pairs.

Published
2019

9. The SeaQuest Spectrometer at Fermilab

Author

SeaQuest Collaboration, Aidala, C. A., Arrington, J. R., Ayuso, C., Bowen, B. M., Bowen, M. L., Bowling, K. L., Brown, A. W., Brown, C. N., Byrd, R., Carlisle, R. E., Chang, T., Chang, W. -C., Chen, A., Chen, J. -Y., Christian, D. C., Chu, X., Dannowitz, B. P., Daugherity, M., Diefenthaler, M., Dove, J., Durandet, C., Fassi, L. El, Erdos, E., Fox, D. M., Geesaman, D. F., Gilman, R., Goto, Y., Guo, L., Guo, R., Hague, T., Hicks, C. R., Holt, R. J., Isenhower, D., Jiang, X., Katich, J. M., Kerns, B. M., Kinney, E. R., Kitts, N. D., Klein, A., Kleinjan, D., Kras, J., Kudo, Y., Lin, P. -J., Liu, D., Liu, K., Liu, M. X., Lorenzon, W., Makins, N. C. R., Martinez, J. D., McClellan, R. E., McDonald, B., McGaughey, P. L., McNease, S. E., Medeiros, M. M., Miller, B., Miller, A. J., Miyasaka, S., Miyachi, Y., Mooney, I. A., Morton, D. H., Nadim, B., Nagai, K., Nakahara, K., Nakano, K., Nara, S., Obata, S., Peng, J. C., Prasad, S., Puckett, A. J. R., Ramson, B. J., Raymond, R. S., Reimer, P. E., Rubin, J. G., Salinas, R., Sanftl, F., Sawada, S., Sawada, T., Scott, M. B. C., Selensky, L. E., Shibata, T. -A., Shiu, S., Su, D., Tadepalli, A. S., Teo, M., Tice, B. G., Towell, C. L., Towell, R. S., Uemura, S., Wang, S. G., Watson, S., White, N., Wickes, A. B., Wood, M. R., Wu, J., Xi, Z., Ye, Z., and Yin, Y.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The SeaQuest spectrometer at Fermilab was designed to detect oppositely-charged pairs of muons (dimuons) produced by interactions between a 120 GeV proton beam and liquid hydrogen, liquid deuterium and solid nuclear targets. The primary physics program uses the Drell-Yan process to probe antiquark distributions in the target nucleon. The spectrometer consists of a target system, two dipole magnets and four detector stations. The upstream magnet is a closed-aperture solid iron magnet which also serves as the beam dump, while the second magnet is an open aperture magnet. Each of the detector stations consists of scintillator hodoscopes and a high-resolution tracking device. The FPGA-based trigger compares the hodoscope signals to a set of pre-programmed roads to determine if the event contains oppositely-signed, high-mass muon pairs.

Published
2017

11. Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS)

Author

Grivas, P., Loriot, Y., Morales-Barrera, R., Teo, M. Y., Zakharia, Y., Feyerabend, S., Vogelzang, N. J., Grande, E., Adra, N., Alva, A., Necchi, A., Rodriguez-Vida, A., Gupta, S., Josephs, D. H., Srinivas, S., Wride, K., Thomas, D., Simmons, A., Loehr, A., Dusek, R. L., Nepert, D., and Chowdhury, S.

Published
2021
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12. Is there an oncological interest in the combination of CRS/HIPEC for peritoneal carcinomatosis of HCC? Results of a multicenter international study

Author

Ahrendt, S.A., Baik, S.H., Bhatt, A., Cachin, P., Ceelen, W., De Hingh, I., De Simone, M., Dubé, P., Edwards, R.P., Franko, J., Gonzalez-Bayon, L., Gushchin, V., Holtzman, M.P., Hsieh, M.-C., Kecmanovic, D., Lee, K.W., Lehmann, K., Levine, E.A., Liu, Y., Mehta, S., Morris, D.L., O'Dwyer, S., Orsenigo, E., Pande, P.K., Park, E.J., Pingpank, J.F., Piso, P., Rajan, F., Rau, B., Sardi, A., Sideris, L., Sommariva, A., Tentes, A.A.K., Teo, M., Yarema, R., Yonemura, Y., Younan, R., Zaveri, S.S., Zeh, H.J., Abba, J., Abboud, K., Alyami, M., Arvieux, C., Bakrin, N., Bereder, J.-M., Bouzard, D., Brigand, C., Carrère, S., Delroeux, D., Dumont, F., Eveno, C., Facy, O., Guyon, F., Ferron, G., Glehen, O., Kianmanesh, R., Lo Dico, R., Lorimier, G., Marchal, F., Mariani, P., Meeus, P., Msika, S., Ortega-Deballon, P., Paquette, B., Passot, G., Peyrat, P., Pirro, N., Pocard, M., Porcheron, J., Rat, P., Sgarbura, O., Thibaudeau, E., Tuech, J.-J., Zinzindohoue, F., Mehta, Sanket, Schwarz, Lilian, Spiliotis, John, Hsieh, Mao-Chih, Akaishi, Eduardo H., Goere, Diane, Sugarbaker, Paul H., Baratti, Dario, Quenet, François, Bartlett, David L., Villeneuve, Laurent, and Kepenekian, Vahan

Published
2018
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15. OC-0272 Organ preservation in rectal cancer: the randomised STAR-TREC phase II trial

Author

Marijnen, C., primary, de Wilt, J., additional, Bach, S., additional, Peters, F., additional, Spindler, K., additional, Appelt, A., additional, Teo, M., additional, Homer, V., additional, Abbott, N., additional, Geh, I., additional, Korsgen, S., additional, Al-Najami, I., additional, Rombouts, A., additional, Christensen, P., additional, Gilbert, A., additional, Navarro-Nunez, L., additional, Quirke, P., additional, West, N., additional, and Sebag-Montefiore, D., additional

Published
2023
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16. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, S, Kiemeney, LA, Choudhury, PP, Milne, RL, de Maturana, EL, Ye, Y, Joseph, V, Florez-Vargas, O, Dyrskjot, L, Figueroa, J, Dutta, D, Giles, GG, Hildebrandt, MAT, Offit, K, Kogevinas, M, Weiderpass, E, McCullough, ML, Freedman, ND, Albanes, D, Kooperberg, C, Cortessis, VK, Karagas, MR, Johnson, A, Schwenn, MR, Baris, D, Furberg, H, Bajorin, DF, Cussenot, O, Cancel-Tassin, G, Benhamou, S, Kraft, P, Porru, S, Carta, A, Bishop, T, Southey, MC, Matullo, G, Fletcher, T, Kumar, R, Taylor, JA, Lamy, P, Prip, F, Kalisz, M, Weinstein, SJ, Hengstler, JG, Selinski, S, Harland, M, Teo, M, Kiltie, AE, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schned, A, Lenz, P, Riboli, E, Brennan, P, Tjonneland, A, Otto, T, Ovsiannikov, D, Volkert, F, Vermeulen, SH, Aben, KK, Galesloot, TE, Turman, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Hohensee, C, Hunt, R, V. Patel, A, Huang, W-Y, Thorleifsson, G, Gago-Dominguez, M, Amiano, P, Golka, K, Stern, MC, Yan, W, Liu, J, Alfred, S, Katta, S, Hutchinson, A, Hicks, B, Wheeler, WA, Purdue, MP, McGlynn, KA, Kitahara, CM, Haiman, CA, Greene, MH, Rafnar, T, Chatterjee, N, Chanock, SJ, Wu, X, Real, FX, Silverman, DT, Garcia-Closas, M, Stefansson, K, Prokunina-Olsson, L, Malats, N, Rothman, N, Koutros, S, Kiemeney, LA, Choudhury, PP, Milne, RL, de Maturana, EL, Ye, Y, Joseph, V, Florez-Vargas, O, Dyrskjot, L, Figueroa, J, Dutta, D, Giles, GG, Hildebrandt, MAT, Offit, K, Kogevinas, M, Weiderpass, E, McCullough, ML, Freedman, ND, Albanes, D, Kooperberg, C, Cortessis, VK, Karagas, MR, Johnson, A, Schwenn, MR, Baris, D, Furberg, H, Bajorin, DF, Cussenot, O, Cancel-Tassin, G, Benhamou, S, Kraft, P, Porru, S, Carta, A, Bishop, T, Southey, MC, Matullo, G, Fletcher, T, Kumar, R, Taylor, JA, Lamy, P, Prip, F, Kalisz, M, Weinstein, SJ, Hengstler, JG, Selinski, S, Harland, M, Teo, M, Kiltie, AE, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schned, A, Lenz, P, Riboli, E, Brennan, P, Tjonneland, A, Otto, T, Ovsiannikov, D, Volkert, F, Vermeulen, SH, Aben, KK, Galesloot, TE, Turman, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Hohensee, C, Hunt, R, V. Patel, A, Huang, W-Y, Thorleifsson, G, Gago-Dominguez, M, Amiano, P, Golka, K, Stern, MC, Yan, W, Liu, J, Alfred, S, Katta, S, Hutchinson, A, Hicks, B, Wheeler, WA, Purdue, MP, McGlynn, KA, Kitahara, CM, Haiman, CA, Greene, MH, Rafnar, T, Chatterjee, N, Chanock, SJ, Wu, X, Real, FX, Silverman, DT, Garcia-Closas, M, Stefansson, K, Prokunina-Olsson, L, Malats, N, and Rothman, N

Abstract

BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. OBJECTIVE: To identify new susceptibility variants for bladder cancer in a meta-analysis of new and existing genome-wide genotype data. DESIGN, SETTING, AND PARTICIPANTS: Data from 32 studies that includes 13,790 bladder cancer cases and 343,502 controls of European ancestry were used for meta-analysis. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSES: Log-additive associations of genetic variants were assessed using logistic regression models. A fixed-effects model was used for meta-analysis of the results. Stratified analyses were conducted to evaluate effect modification by sex and smoking status. A polygenic risk score (PRS) was generated on the basis of known and novel susceptibility variants and tested for interaction with smoking. RESULTS AND LIMITATIONS: Multiple novel bladder cancer susceptibility loci (6p.22.3, 7q36.3, 8q21.13, 9p21.3, 10q22.1, 19q13.33) as well as improved signals in three known regions (4p16.3, 5p15.33, 11p15.5) were identified, bringing the number of independent markers at genome-wide significance (p < 5 × 10-8) to 24. The 4p16.3 (FGFR3/TACC3) locus was associated with a stronger risk for women than for men (p-interaction = 0.002). Bladder cancer risk was increased by interactions between smoking status and genetic variants at 8p22 (NAT2; multiplicative p value for interaction [pM-I] = 0.004), 8q21.13 (PAG1; pM-I = 0.01), and 9p21.3 (LOC107987026/MTAP/CDKN2A; pM-I = 0.02). The PRS based on the 24 independent GWAS markers (odds ratio per standard deviation increase 1.49, 95% confidence interval 1.44-1.53), which also showed comparable results in two prospective cohorts (UK Biobank, PLCO trial), revealed an approximately fourfold difference in the lifetime risk of bladder cancer according to the PRS (e.g., 1st vs 10th decile) for both smokers and nonsmokers. CONCLUSIONS: We report novel loci associated

Published
2023

17. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights.

Author

Koutros, S., Kiemeney, L.A., Pal Choudhury, P., Milne, R.L., Lopez de Maturana, E., Ye, Y., Joseph, V., Florez-Vargas, O., Dyrskjøt, L., Figueroa, J., Dutta, D., Giles, G.G., Hildebrandt, M.A.T., Offit, K., Kogevinas, M., Weiderpass, E., McCullough, M.L., Freedman, N.D., Albanes, D., Kooperberg, C., Cortessis, V.K., Karagas, M.R., Johnson, A., Schwenn, M.R., Baris, D., Furberg, H., Bajorin, D.F., Cussenot, O., Cancel-Tassin, G., Benhamou, S., Kraft, P., Porru, S., Carta, A., Bishop, T., Southey, M.C., Matullo, G., Fletcher, T., Kumar, R., Taylor, J.A., Lamy, P., Prip, F., Kalisz, M., Weinstein, S.J., Hengstler, J.G., Selinski, S., Harland, M., Teo, M., Kiltie, A.E., Tardón, A., Serra, C., Carrato, A., García-Closas, R., Lloreta, J., Schned, A., Lenz, P., Riboli, E., Brennan, P., Tjønneland, A., Otto, T., Ovsiannikov, D., Volkert, F., Vermeulen, S.H., Aben, K.K.H., Galesloot, T.E., Turman, C., Vivo, I. De, Giovannucci, E., Hunter, D.J., Hohensee, C., Hunt, R., Patel, A.V., Huang, W.Y., Thorleifsson, G., Gago-Dominguez, M., Amiano, P., Golka, K., Stern, M.C., Yan, W., Liu, J., Li, S.A., Katta, S., Hutchinson, A., Hicks, B., Wheeler, W.A., Purdue, M.P., McGlynn, K.A., Kitahara, C.M., Haiman, C.A., Greene, M.H., Rafnar, T., Chatterjee, N., Chanock, S.J., Wu, X., Real, F.X., Silverman, D.T., Garcia-Closas, M., Stefansson, K., Prokunina-Olsson, L., Malats, N., Rothman, N., Koutros, S., Kiemeney, L.A., Pal Choudhury, P., Milne, R.L., Lopez de Maturana, E., Ye, Y., Joseph, V., Florez-Vargas, O., Dyrskjøt, L., Figueroa, J., Dutta, D., Giles, G.G., Hildebrandt, M.A.T., Offit, K., Kogevinas, M., Weiderpass, E., McCullough, M.L., Freedman, N.D., Albanes, D., Kooperberg, C., Cortessis, V.K., Karagas, M.R., Johnson, A., Schwenn, M.R., Baris, D., Furberg, H., Bajorin, D.F., Cussenot, O., Cancel-Tassin, G., Benhamou, S., Kraft, P., Porru, S., Carta, A., Bishop, T., Southey, M.C., Matullo, G., Fletcher, T., Kumar, R., Taylor, J.A., Lamy, P., Prip, F., Kalisz, M., Weinstein, S.J., Hengstler, J.G., Selinski, S., Harland, M., Teo, M., Kiltie, A.E., Tardón, A., Serra, C., Carrato, A., García-Closas, R., Lloreta, J., Schned, A., Lenz, P., Riboli, E., Brennan, P., Tjønneland, A., Otto, T., Ovsiannikov, D., Volkert, F., Vermeulen, S.H., Aben, K.K.H., Galesloot, T.E., Turman, C., Vivo, I. De, Giovannucci, E., Hunter, D.J., Hohensee, C., Hunt, R., Patel, A.V., Huang, W.Y., Thorleifsson, G., Gago-Dominguez, M., Amiano, P., Golka, K., Stern, M.C., Yan, W., Liu, J., Li, S.A., Katta, S., Hutchinson, A., Hicks, B., Wheeler, W.A., Purdue, M.P., McGlynn, K.A., Kitahara, C.M., Haiman, C.A., Greene, M.H., Rafnar, T., Chatterjee, N., Chanock, S.J., Wu, X., Real, F.X., Silverman, D.T., Garcia-Closas, M., Stefansson, K., Prokunina-Olsson, L., Malats, N., and Rothman, N.

Abstract

01 juli 2023, Item does not contain fulltext, BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. OBJECTIVE: To identify new susceptibility variants for bladder cancer in a meta-analysis of new and existing genome-wide genotype data. DESIGN, SETTING, AND PARTICIPANTS: Data from 32 studies that includes 13,790 bladder cancer cases and 343,502 controls of European ancestry were used for meta-analysis. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSES: Log-additive associations of genetic variants were assessed using logistic regression models. A fixed-effects model was used for meta-analysis of the results. Stratified analyses were conducted to evaluate effect modification by sex and smoking status. A polygenic risk score (PRS) was generated on the basis of known and novel susceptibility variants and tested for interaction with smoking. RESULTS AND LIMITATIONS: Multiple novel bladder cancer susceptibility loci (6p.22.3, 7q36.3, 8q21.13, 9p21.3, 10q22.1, 19q13.33) as well as improved signals in three known regions (4p16.3, 5p15.33, 11p15.5) were identified, bringing the number of independent markers at genome-wide significance (p < 5 × 10(-8)) to 24. The 4p16.3 (FGFR3/TACC3) locus was associated with a stronger risk for women than for men (p-interaction = 0.002). Bladder cancer risk was increased by interactions between smoking status and genetic variants at 8p22 (NAT2; multiplicative p value for interaction [p(M-I)] = 0.004), 8q21.13 (PAG1; p(M-I) = 0.01), and 9p21.3 (LOC107987026/MTAP/CDKN2A; p(M-I) = 0.02). The PRS based on the 24 independent GWAS markers (odds ratio per standard deviation increase 1.49, 95% confidence interval 1.44-1.53), which also showed comparable results in two prospective cohorts (UK Biobank, PLCO trial), revealed an approximately fourfold difference in the lifetime risk of bladder cancer according to the PRS (e.g., 1st vs 10th decile) for both smokers and nonsmokers. CONCLUSIONS: We report novel loci ass

Published
2023

19. Nasopharyngeal Cancer

Author

Chan, Anthony TC, Chan, M. D., Teo, Peter ML, Teo, M. D., Johnson, Philip J, Johnson, M. D., Rosen, Steven T., editor, Bruce, Brockstein, editor, and Gregory, Masters, editor

Published
2003
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20. Hide & Seek: Privacy-preserving rebalancing on payment channel networks

Author

Avarikioti, Z. (Zeta), Pietrzak, K.Z. (Krzysztof), Salem, I. (Iosif), Schmid, S. (Stefan), Tiwari, S.S.K. (Samarth), Teo, M. (Michelle), Avarikioti, Z. (Zeta), Pietrzak, K.Z. (Krzysztof), Salem, I. (Iosif), Schmid, S. (Stefan), Tiwari, S.S.K. (Samarth), and Teo, M. (Michelle)

Abstract

Payment channels effectively move the transaction load off-chain thereby successfully addressing the inherent scalability problem most cryptocurrencies face. A major drawback of payment channels is the need to “top up” funds on-chain when a channel is depleted. Rebalancing was proposed to alleviate this issue, where parties with depleting channels move their funds along a cycle to replenish their channels off-chain. Protocols for rebalancing so far either introduce local solutions or compromise privacy. In this work, we present an opt-in rebalancing protocol that is both private and globally optimal, meaning our protocol maximizes the total amount of rebalanced funds. We study rebalancing from the framework of linear programming. To obtain full privacy guarantees, we leverage multi-party computation in solving the linear program, which is executed by selected participants to maintain efficiency. Finally, we efficiently decompose the rebalancing solution into incentive-compatible cycles which conserve user balances when executed atomically.

Published
2022
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21. Procedures performed during neurosurgery residency in Europe

Author

Stienen, M. N., Freyschlag, C. F., Schaller, K., Meling, T., Al-Amin, A., Al-Mahfoudh, R., Amelot, A., Arvidsson, L., Athanasiou, A., Avellan, C. I. A., Bauchet, L., Berilazic, L., Bolger, C., Bourdillon, P., Boviatsis, S., Bozinov, O., Branco, P., Braunsdorf, W., Cahill, J., Clusmann, H., Conrad, J., Cordier, D., Cristino, N., Djilvesi, D., Duerinck, J., Dumot, C., Durak, M. A., Eisenring, C. V., Esposito, G., Finiels, P. -J., Flaskas, T., Fuentes, S., Ganau, M., Georgiadis, I., Georgiopoulos, M., Giakoumettis, D., Gilis, N., Gradil, C., Grau, S. J., Grin, A., Hadjigeorgiou, G., Halatsch, M. -E., Hecht, N., Holling, M., Ilic, R., Iken, L., Santos, N. I., Jacquesson, T., Jalloh, I., Jelaca, B., Kaestner, S., Kalasauskas, D., Kaliyev, A., Kleiber, J. -C., Konczalla, J., Kothbauer, K. F., Kovacevic, V., Krajcinovic, N., Krieg, S. M., Kamarainen, O. -P., Lapcic, M., Lapras, C., Ljungqvist, J., W. B., Lo, Lubrano, V., Majovsky, M., Manet, R., Marchi, F., Medetov, Y., Meling, T. R., Melloni, I., Melot, A., Mertens, P., Metcalfe, S., Moerkve, S. H., Mora, A. R., Musabelliu, E., Naushahi, M. J., Nurzhan, A., Omerhodzic, I., Paldor, I., Pallud, J., Papanastassiou, V., Papic, V., Paschalis, T., Payer, M., Peerdeman, S. M., Peruzzi, P., Segerlind, J. P., Posti, J. P., Proust, F., Regli, L., Rinne, J., Roche, P. -H., Rocka, S., Rotermund, R., Rutherford, S. A., Ratsep, T., Ruter, A., Saarenpaa, I. M., Samanci, M. Y., Samardzic, M., Sampron, N., Sandvik, U., Scerrati, A., Schneider, M., Schul, D. B., Sengul, G., Simon, E., Sinha, S., Solheim, O., Spatola, G., Spektor, S., Sundblom, J., Syrmos, N. C., Teo, M., Thomson, S., Tonchev, N., Tosic, L., Vandertop, W. P., von der Brelie, C., Vuk, A., Walkden, J., Wendel, C., Yaqout, M., Yusupova, M., Zollino, G., University of Zurich, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, IOO, and ANS - Systems & Network Neuroscience

Subjects
Adult, Male, Neurosurgery/education, medicine.medical_specialty, Certification, Caseload, Europe, Neurosurgery, Residency, Training program, Working hour restriction, 610 Medicine & health, Neurosurgical Procedures, NO, 03 medical and health sciences, 10180 Clinic for Neurosurgery, 0302 clinical medicine, Surveys and Questionnaires, Germany, Medicine, Humans, Child, Greece, business.industry, Female sex, Internship and Residency, Mean age, Surgical procedures, Middle Aged, Current analysis, United Kingdom, Original Article - Neurosurgery Training, ddc:616.8, 030220 oncology & carcinogenesis, Surgery, Female, Neurology (clinical), France, business, 030217 neurology & neurosurgery, Switzerland, Demography
Abstract

Background In a previous article (10.1007/s00701-019-03888-3), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries (p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.

Published
2020

23. Government and industry investment plays crucial role in further establishment, evolution, and diversification of insect agriculture: a case example from the United States

Author

Tomberlin, J.K., primary, Picard, C.J., additional, Jordan, H.R., additional, Preyer, C., additional, Warburton, C., additional, Crowley, P., additional, Zheng, R., additional, Boulanger, F.X., additional, Banks, I., additional, Lefranc, M., additional, Zorrilla, M.J., additional, Olson, G., additional, Aid, G., additional, Fluker, D., additional, Bench, B.J., additional, Teo, M., additional, Richards, C.S., additional, Jones, C., additional, Gonzalez, J., additional, and Eljendy, M., additional

Published
2022
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30. Multicentre, deep learning, synthetic-CT generation for ano-rectal MR-only radiotherapy treatment planning

Author

Bird, D, Nix, MG, McCallum, H, Teo, M, Gilbert, A, Casanova, N, Cooper, R, Buckley, DL, Sebag-Montefiore, D, Speight, R, Al-Qaisieh, B, and Henry, AM

Abstract

Background and purpose Comprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due to the limited number of site specific synthetic-CT (sCT) dosimetric assessments in the literature. This study aims to provide a comprehensive assessment of a deep learning-based, conditional generative adversarial network (cGAN) model for a large ano-rectal cancer cohort. The following challenges were investigated; T2-SPACE MR sequences, patient data from multiple centres and the impact of sex and cancer site on sCT quality. Method RT treatment position CT and T2-SPACE MR scans, from two centres, were collected for 90 ano-rectal patients. A cGAN model trained using a focal loss function, was trained and tested on 46 and 44 CT-MR ano-rectal datasets, paired using deformable registration, respectively. VMAT plans were created on CT and recalculated on sCT. Dose differences and gamma indices assessed sCT dosimetric accuracy. A linear mixed effect (LME) model assessed the impact of centre, sex and cancer site. Results A mean PTV D95% dose difference of 0.1% (range: −0.5% to 0.7%) was found between CT and sCT. All gamma index (1%/1 mm threshold) measurements were >99.0%. The LME model found the impact of modality, cancer site, sex and centre was clinically insignificant (effect ranges: −0.4% and 0.3%). The mean dose difference for all OAR constraints was 0.1%. Conclusion Focal loss cGAN models using T2-SPACE MR sequences from multiple centres can produce generalisable, dosimetrically accurate sCTs for ano-rectal cancers.

Published
2021

33. OC-0524 Evidence supporting anal and rectal cancer MR-only radiotherapy planning clinical implementation

Author

Bird, D., primary, Nix, M., additional, Tyyger, M., additional, Beasley, M., additional, McCallum, H., additional, Teo, M., additional, Casanova, N., additional, Cooper, R., additional, Gilbert, A., additional, Buckley, D., additional, Sebag-Montefiore, D., additional, Henry, A., additional, Speight, R., additional, and Al-Qaisieh, B., additional

Published
2021
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34. Risk of Rupture After Intracranial Aneurysm Growth

Author

Kamp, L.T. van der, Rinkel, G.J., Verbaan, D., Berg, R van den, Vandertop, W.P., Murayama, Y., Ishibashi, T., Lindgren, A., Koivisto, T., Teo, M., George, J., Agid, R., Radovanovic, I., Moroi, J., Igase, K., Wijngaard, I.R. van den, Rahi, M., Rinne, J., Kuhmonen, J., Boogaarts, H.D., Wong, G.K.C., Abrigo, J.M., Morita, A., Shiokawa, Y., Hackenberg, K.A.M., Etminan, N., Schaaf, I.C. van der, Zuithoff, N.P., Vergouwen, M.D., Kamp, L.T. van der, Rinkel, G.J., Verbaan, D., Berg, R van den, Vandertop, W.P., Murayama, Y., Ishibashi, T., Lindgren, A., Koivisto, T., Teo, M., George, J., Agid, R., Radovanovic, I., Moroi, J., Igase, K., Wijngaard, I.R. van den, Rahi, M., Rinne, J., Kuhmonen, J., Boogaarts, H.D., Wong, G.K.C., Abrigo, J.M., Morita, A., Shiokawa, Y., Hackenberg, K.A.M., Etminan, N., Schaaf, I.C. van der, Zuithoff, N.P., and Vergouwen, M.D.

Abstract

Item does not contain fulltext, IMPORTANCE: Unruptured intracranial aneurysms not undergoing preventive endovascular or neurosurgical treatment are often monitored radiologically to detect aneurysm growth, which is associated with an increase in risk of rupture. However, the absolute risk of aneurysm rupture after detection of growth remains unclear. OBJECTIVE: To determine the absolute risk of rupture of an aneurysm after detection of growth during follow-up and to develop a prediction model for rupture. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data were obtained from 15 international cohorts. Patients 18 years and older who had follow-up imaging for at least 1 untreated unruptured intracranial aneurysm with growth detected at follow-up imaging and with 1 day or longer of follow-up after growth were included. Fusiform or arteriovenous malformation-related aneurysms were excluded. Of the 5166 eligible patients who had follow-up imaging for intracranial aneurysms, 4827 were excluded because no aneurysm growth was detected, and 27 were excluded because they had less than 1 day follow-up after detection of growth. EXPOSURES: All included aneurysms had growth, defined as 1 mm or greater increase in 1 direction at follow-up imaging. MAIN OUTCOMES AND MEASURES: The primary outcome was aneurysm rupture. The absolute risk of rupture was measured with the Kaplan-Meier estimate at 3 time points (6 months, 1 year, and 2 years) after initial growth. Cox proportional hazards regression was used to identify predictors of rupture after growth detection. RESULTS: A total of 312 patients were included (223 [71%] were women; mean [SD] age, 61 [12] years) with 329 aneurysms with growth. During 864 aneurysm-years of follow-up, 25 (7.6%) of these aneurysms ruptured. The absolute risk of rupture after growth was 2.9% (95% CI, 0.9-4.9) at 6 months, 4.3% (95% CI, 1.9-6.7) at 1 year, and 6.0% (95% CI, 2.9-9.1) at 2 years. In multivariable analyses, predictors of rupture were size (7 mm or larger hazard ratio

Published
2021

35. A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial

Author

Hudson, EM, Noutch, S, Brown, S, Adapala, R, Bach, SP, Burnett, C, Burrage, A, Gilbert, A, Hawkins, M, Howard, D, Jefford, M, Kochhar, R, Saunders, M, Seligmann, J, Smith, A, Teo, M, Webb, EJ, Webster, A, West, N, Sebag-Montefiore, D, Gollins, S, and Appelt, AL

Subjects
Clinical Trials, Phase II as Topic, Postoperative Complications, Rectal Neoplasms, Quality of Life, Humans, Multicenter Studies as Topic, Chemoradiotherapy, Syndrome, General Medicine, Randomized Controlled Trials as Topic
Abstract

IntroductionThe standard of care for patients with localised rectal cancer is radical surgery, often combined with preoperative neoadjuvant (chemo)radiotherapy. While oncologically effective, this treatment strategy is associated with operative mortality risks, significant morbidity and stoma formation. An alternative approach is chemoradiotherapy to try to achieve a sustained clinical complete response (cCR). This non-surgical management can be attractive, particularly for patients at high risk of surgical complications. Modern radiotherapy techniques allow increased treatment conformality, enabling increased radiation dose to the tumour while reducing dose to normal tissue. The objective of this trial is to assess if radiotherapy dose escalation increases the cCR rate, with acceptable toxicity, for treatment of patients with early rectal cancer unsuitable for radical surgery.Methods and analysisAPHRODITE (A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer) is a multicentre, open-label randomised controlled phase II trial aiming to recruit 104 participants from 10 to 12 UK sites. Participants will be allocated with a 2:1 ratio of intervention:control. The intervention is escalated dose radiotherapy (62 Gy to primary tumour, 50.4 Gy to surrounding mesorectum in 28 fractions) using simultaneous integrated boost. The control arm will receive 50.4 Gy to the primary tumour and surrounding mesorectum. Both arms will use intensity-modulated radiotherapy and daily image guidance, combined with concurrent chemotherapy (capecitabine, 5-fluorouracil/leucovorin or omitted). The primary endpoint is the proportion of participants with cCR at 6 months after start of treatment. Secondary outcomes include early and late toxicities, time to stoma formation, overall survival and patient-reported outcomes (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires QLQ-C30 and QLQ-CR29, low anterior resection syndrome (LARS) questionnaire).Ethics and disseminationThe trial obtained ethical approval from North West Greater Manchester East Research Ethics Committee (reference number 19/NW/0565) and is funded by Yorkshire Cancer Research. The final trial results will be published in peer-reviewed journals and adhere to International Committee of Medical Journal Editors guidelines.Trial registration numberISRCTN16158514.

Published
2022

37. Poster presentations

Author

Olds, T., Blunden, S., Petkov, J., Forchino, F., Teng, A., Bartle, A., Sadeh, A., Mindell, J., Thompson, K., Richdale, A., Schreck, K., Gibson, R., Gander, P., Elder, D., Levendowski, D., Rosen, C., Berka, C., Zavora, T., Olmstead, R., Popovic, D., Westbrook, P., Piteo, A., Roberts, R., Nettelbeck, T., Lushington, K., Van Den Heuvel, C., Kohler, M., Martin, J., Kennedy, D., Jackman, A., Davey, M., Nixon, G., Hope, S., Catroppa, C., O’Driscoll, D., Anderson, V., Trinder, J., Horne, R., Milte, C., Sinn, N., Quach, J., Hiscock, H., Wake, M., Fulton, M., Sciberras, E., Efron, D., Oberklaid, F., Jay, S., Eng, A., ’t Mannetje, A., Cheng, S., Douwes, J., Ellison-Loschmann, L., Mclean, D., Pearce, N., Zhou, X., Sargent, C., Darwent, D., Ferguson, S., Paech, G., Mattews, R., Williams, L., Roach, G., Martin, D., Lastella, A., Matthews, R., Wilsmore, N., Galante, R., Lee, J., Barnes, M., Kennedy, G., Howard, M., Smith, S., Doye, G., Mangie, J., Signal, L., Phipps-Nelson, J., Redman, J., Rajaratnam, S., Lamond, N., Dorrian, J., Whitwell, B., Rogers, N., Sutherland, K., Chan, A. S. L., Deane, S. A., Zeng, B., Lee, R. W. W., Darendeliler, M. A., Cistulli, P. A., Spong, J., Brown, D., Berlowitz, D., Keihani, S. M., Hillman, D., Collins, A., Jackson, M., Pierce, R., O’Donoghue, F., Bignold, J., Mercer, J., Gorman, M., Mcevoy, D., Antic, N., Catcheside, P., Verma, M., Wheatley, J., Amis, T., Marshall, N., Grunstein, R., Peltonen, M., Carlson, L., Hedner, J., Stenlof, K., Sjostrom, L., Williams, S., Kennerson, M., Liu, P., Little, C., Watson, A., Dunn, N., Beevers, A., Douglas, J., Ruehland, W., Singh, P., Thornton, A., Copland, J., Rochford, P., Perri, R., Ward, K., Palmer, L., Mukherjee, S., Cooper, M., Love, G., Fedson, A., Simpson, L., Edwards, C., Szegner, B., Wong, K., Cistulli, P., Marks, G., Zwar, N., Norman, M., Middleton, S., Sullivan, C., Terrill, P., Mason, D., Parsley, C., Dakin, C., Wilson, S., Khandoker, A., Palaniswami, M., Karunajeewa, A., Abeyratne, U., Hukins, C., Lee, S., Borodzicz, J., Amatoury, J., Robinson, T., Ip, T., Mackenzie, J., Scott, E., Hickie, I., Lovato, N., Lack, L., Wright, H., Muller, D., van Den Berg, M., van Dongen, H. P. A., Miller, B., Orr, R., O’Connor, H., Chow, C. M., Litchfield, C., Glozier, N., Ogeil, R., Broadbear, J., Bakar, R. A., Denotti, A., Rae, C., Bartlett, D. J., Wong, K. K. H., Yang, Q., Walton, D., Sachinwalla, T., Grunstein, R. R., Dang, D., Cunnington, D., Swieca, J., Chen, Y., Young, A., Jakobson, A., Fitzgerald, P., Conduit, R., Smith, D., Jorgensen, G., Lee, H. L., Simpson, G., Ferns, J., Shepherd, K., James, A., Musk, A., Hunter, M., Eastwood, P., Duce, B., Al-Abri, M., Al-Hashmi, K., Jaju, D., Al-Rawas, O., Hassan, M., Ngan, A., Marshall, M. J., Dawson, A. D. G., Bucks, R. S., Walker, A., Hensley, R., Machaalani, R., Waters, K., Harrison, H., Tai, A., Raju, S., Williamson, B., Richardson, H. L., Walker, A. M., Horne, R. S. C., Yuill, M., Harris, M. A., Griffiths, A., Trang, L., Paramalingam, N., Davis, E., Jones, T., Stick, S., Wilson, A., Suresh, S., Cooper, D., Walsh, J., Maddison, K., Hoegh, T., Daulatzai, M., Karmakar, C., Khan, N., Bei, B., Nicholas, C., Worsnop, C., Jordan, A., Saboisky, J., White, D., Malhotra, A., Stadler, D., Mcevoy, R. D., Paul, D., Bradley, J., Maclean, J., Fitzgerald, D., Witcombe, N., Yiallourou, S., Sands, S., Ratnavadivel, R., George, K., Ryan, M., Thompson, C., Catcheside, P. G., Harmer, L., Deacon, N., Wang, D., Piper, A., Yee, B., Mihai, R., Davey, M. J., Nixon, G. M., Tyler, L., Vidal, A., Lambert, S., Tolson, J., Henderson, M., Maree, B., Campbell, A., Neill, A., Heraganahally, S., Bowden, J., Carney, S., Robinson, S., Sajkov, D., Bakker, J., Rixon, K., Hanssen, K., Chia, C., Sather, T., Keir, G., Chikazaza, M., Shirlaw, T., Jones, D., West, J., Dooney, N., Teo, M. Y., Falland, K., Phung, S., Cullen, S., Kevin, G., Mcardle, N., Joosten, S., Turton, A., Hamilton, G., Lavercombe, M., Hocking, V., Clarence, M., Thien, F., Senin, S. R., Ong, T. H., Ong, G., Roebuck, T., Ho, S., Langan-Fox, J., Davis, S., Van, E., Paul, E., Naughton, M., Iqbal, S. M., Gray, P., Urquhart, D., Williams, G., Verginis, N., Boynton, A., Gradinger, F., Partinen, M., Stucki, G., Cooper, P., Biggs, S., Dollman, J., Sweeney, B., Jones, L., Milgrom, J., Ericksen, J., Parry, B., Meliska, C., Sorenson, D., Lopez, A., Martinez, F., Nowakowski, S., Hauger, R., Elliott, J., Kripke, D., Duncan, S., Larsson, E., Fuller, J., Krass, I., Saini, B., and Junge, M.

Published
2009
Full Text
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43. Mesorectal radiotherapy for early stage rectal cancer: A novel target volume

Author

Peters, F.P., Teo, M., Appelt, A., Bach, S., Baatrup, G., Wilt, J.H.W. de, Marijnen, Corrie A. M., Sebag-Montefiore, D., Peters, F.P., Teo, M., Appelt, A., Bach, S., Baatrup, G., Wilt, J.H.W. de, Marijnen, Corrie A. M., and Sebag-Montefiore, D.

Abstract

Contains fulltext : 217443.pdf (publisher's version ) (Open Access)

Published
2020

44. In Memoriam: A Memoir for Our Fallen 'Heroes'

Author

Chaurasia, B, Deora, H, El-Ghandour, NMF, Oyesiku, NM, Chaurasia, RK, Schulder, M, Soriano Sanchez, JA, Teo, M, Hernesniemi, J, Linzey, JR, Schwartz, TH, Cohen-Gadol, AA, Lawton, M, Umana, G, Mura, J, Grotenhuis, A, Sinha, AK, Schroeder, HWS, Natarajan, S, Sughrue, ME, Spetzler, RF, Drummond, K, Tanikawa, R, do Seixo Kadri, PA, Kato, Y, Teo, C, Suri, A, Tomasi, SO, Winkler, PA, Scalia, G, Sampron, N, Rasulic, L, Cappabianca, P, Fontanella, MM, Laws, ER, Chaurasia, B, Deora, H, El-Ghandour, NMF, Oyesiku, NM, Chaurasia, RK, Schulder, M, Soriano Sanchez, JA, Teo, M, Hernesniemi, J, Linzey, JR, Schwartz, TH, Cohen-Gadol, AA, Lawton, M, Umana, G, Mura, J, Grotenhuis, A, Sinha, AK, Schroeder, HWS, Natarajan, S, Sughrue, ME, Spetzler, RF, Drummond, K, Tanikawa, R, do Seixo Kadri, PA, Kato, Y, Teo, C, Suri, A, Tomasi, SO, Winkler, PA, Scalia, G, Sampron, N, Rasulic, L, Cappabianca, P, Fontanella, MM, and Laws, ER

Abstract

Even though neurosurgeons exercise these enormous and versatile skills, the COVID-19 pandemic has shaken the fabrics of the global neurosurgical family, jeopardizing human lives, and forcing the entire world to be locked down. We stand on the shoulders of the giants and will not forget their examples and their teachings. We will work to the best of our ability to honor their memory. Professor Harvey Cushing said: "When to take great risks; when to withdraw in the face of unexpected difficulties; whether to force an attempted enucleation of a pathologically favorable tumor to its completion with the prospect of an operative fatality, or to abandon the procedure short of completeness with the certainty that after months or years even greater risks may have to be faced at a subsequent session-all these require surgical judgment which is a matter of long experience." It is up to us, therefore, to keep on the noble path that we have decided to undertake, to accumulate the surgical experience that these icons have shown us, the fruit of sacrifice and obstinacy. Our tribute goes to them; we will always remember their excellent work and their brilliant careers that will continue to enlighten all of us.

Published
2020

45. Phosphonated graphene oxide with high electrocatalytic performance for vanadium redox flow battery

Author

Ebrahim Abouzari-Lotf, Azam Saharkhiz, Mohamed Mahmoud Nasef, Adnan Ripin, Mohammad Etesami, Arshad Ahmad, and Teo M. Ting

Subjects
Battery (electricity), Materials science, Renewable Energy, Sustainability and the Environment, Graphene, Inorganic chemistry, Oxide, Energy Engineering and Power Technology, chemistry.chemical_element, Vanadium, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Flow battery, Redox, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Fuel Technology, chemistry, law, Electrode, 0210 nano-technology, Carbon
Abstract

Development of more efficient electrodes is essential to improve the competitiveness of vanadium redox flow battery (VRFB) systems. Covalent functionalization of carbon structure in graphene oxide with phosphonic acid groups was carried out to enhance the electrode wettability. The phosphonated graphene oxide (P-GO) was characterized and found displaying an improved electrocatalytic performance towards electrooxidation/electroreduction of vanadium ion pairs. The defect in P-GO structure increased the negative charge density on the surface leading to higher vanadium ions tendency for electrooxidation/electroreduction reactions. The battery performance was evaluated using electrodes made of carbon felt hosted GO and P-GO in a single cell VRFB and 180 charge-discharge cycles were recorded. The VRFB with P-GO displayed an improved performance and stable coulombic, voltage and energy efficiency compared to VRFB with GO.

Published
2018

46. A methodology for investigating new nonprecious metal catalysts for PEM fuel cells

Author

Susac, D., Sode, A., P.C. Wong, Teo, M., Bizzottoo, D., Mitchell, K.A.R., Parsons, R.R., and Campbell, S.A.

Subjects
Oxidation-reduction reaction -- Analysis, Fuel cells -- Research, Metal catalysts -- Chemical properties, X-ray spectroscopy -- Usage, X-rays -- Diffraction, X-rays -- Usage, Chemicals, plastics and rubber industries
Abstract

A methodology is described to investigate metal-chalcogen materials as catalysts for the oxygen reduction reaction (ORR) in proton exchange membrane (PEM) fuel cells. This new methodology is illustrated with reference to Co-Se thin films prepared by magnetron sputtering onto a glassy-carbon substrate and a comparison for ORR activity is made between Co-Se powders and a commercial Pt catalyst.

Published
2006

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