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2. Secondary Primary Malignancy Risk in Patients With Cervical Cancer in Taiwan

Author

Teng, Chung-Jen, Huon, Leh-Kiong, Hu, Yu-Wen, Yeh, Chiu-Mei, Chao, Yee, Yang, Muh-Hwa, Chen, Tzeng-Ji, Hung, Yi-Ping, and Liu, Chia-Jen

Subjects
Patient Safety, Health Services, Cervical Cancer, Cancer, Clinical Research, Adult, Aged, Antineoplastic Agents, Carboplatin, Comorbidity, Female, Fluorouracil, Humans, Middle Aged, Neoplasms, Second Primary, Radiotherapy, Registries, Taiwan, Uterine Cervical Neoplasms, Young Adult, Clinical Sciences, Arthritis & Rheumatology
Abstract

To evaluate the risk of secondary primary malignancy (SPM) in patients with cervical cancer using a nationwide population-based dataset.Patients newly diagnosed with cervical cancer between 1997 and 2011 were identified using Taiwan's National Health Insurance database. Patients with antecedent malignancies were excluded. Standardized incidence ratios (SIRs) for SPM were calculated by comparing with the cancer incidence in the general population. Risk factors for cancer development were analyzed using Cox proportional hazard models.During the 14-year study period (follow-up of 223,062 person-years), 2004 cancers developed in 35,175 patients with cervical cancer. The SIR for all cancers was 1.56 (95% confidence interval, 1.50-1.63, P 10, 5 to 10, 1 to 5, and

Published
2015

23. Secondary Primary Malignancy Risk in Patients With Cervical Cancer in Taiwan: A Nationwide Population-Based Study.

Author

Teng, Chung-Jen, Teng, Chung-Jen, Huon, Leh-Kiong, Hu, Yu-Wen, Yeh, Chiu-Mei, Chao, Yee, Yang, Muh-Hwa, Chen, Tzeng-Ji, Hung, Yi-Ping, Liu, Chia-Jen, Teng, Chung-Jen, Teng, Chung-Jen, Huon, Leh-Kiong, Hu, Yu-Wen, Yeh, Chiu-Mei, Chao, Yee, Yang, Muh-Hwa, Chen, Tzeng-Ji, Hung, Yi-Ping, and Liu, Chia-Jen

Abstract

To evaluate the risk of secondary primary malignancy (SPM) in patients with cervical cancer using a nationwide population-based dataset.Patients newly diagnosed with cervical cancer between 1997 and 2011 were identified using Taiwan's National Health Insurance database. Patients with antecedent malignancies were excluded. Standardized incidence ratios (SIRs) for SPM were calculated by comparing with the cancer incidence in the general population. Risk factors for cancer development were analyzed using Cox proportional hazard models.During the 14-year study period (follow-up of 223,062 person-years), 2004 cancers developed in 35,175 patients with cervical cancer. The SIR for all cancers was 1.56 (95% confidence interval, 1.50-1.63, P < 0.001). SIRs for follow-up periods of >10, 5 to 10, 1 to 5, and <1 year were 1.37, 1.51, 1.34, and 2.59, respectively. After the exclusion of SPM occurring within 1 year of cervical cancer diagnosis, SIRs were significantly higher for cancers of the esophagus (2.05), stomach (1.38), colon, rectum, and anus (1.36); lung and mediastinum (2.28), bone and soft tissue (2.23), uterus (3.76), bladder (2.26), and kidneys (1.41). Multivariate analysis showed that age ≥60 was a significant SPM risk factor (hazard ratio [HR] 1.59). Different treatments for cervical cancer, including radiotherapy (HR 1.41) and chemotherapy (HR 1.27), had different impacts on SPM risk. Carboplatin and fluorouracil independently increased SPM risk in cervical cancer patients.Patients with cervical cancer are at increased risk of SPM development. Age ≥60 years, chemotherapy, and radiotherapy are independent risk factors. Carboplatin and fluorouracil also increased SPM risk independently. Close surveillance of patients at high risk should be considered for the early detection of SPMs.

Published
2015

24. Cancer Risk in Patients With Empyema

Author

Teng, Chung-Jen, Hu, Yu-Wen, Yeh, Chiu-Mei, Chen, Tzeng-Ji, and Liu, Chia-Jen

Subjects
Adult, Aged, 80 and over, Liver Cirrhosis, Male, Observational Study, Middle Aged, Diabetes Complications, Young Adult, Sex Factors, Risk Factors, Neoplasms, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Female, Empyema, Research Article, Aged
Abstract

Supplemental Digital Content is available in the text, This study aimed to evaluate cancer risk and possible risk factors in patients diagnosed with empyema. A total of 31,636 patients with newly diagnosed empyema between January 1, 1999 and December 31, 2010 were included in this study. Standardized incidence ratios (SIRs) were calculated to compare the cancer incidence in these empyema patients to that in the general population. Adjusted hazard ratios were also calculated to investigate whether characteristics increased cancer risk. During the 12-year study period, 2,654 cancers occurred in 31,636 patients with empyema, yielding an SIR of 2.67 (95% confidence interval [CI] 2.57–2.78). We excluded cancer that occurred within 1 year to avoid surveillance bias. The cancer risk remained significantly increased (SIR 1.50, 95% CI 1.41–1.58). Specifically, patients with empyema had higher SIR of cancers of the head and neck (1.50, 95% CI 1.41–1.58), esophagus (2.56, 95% CI 1.92–3.33), stomach (1.49, 95% CI 1.16–1.89), liver and biliary tract (2.18, 95% CI 1.93–2.45), and lung and mediastinum (1.62, 95% CI 1.39–1.86). Age ≥ 60, male sex, diabetes mellitus, and liver cirrhosis were independent risk factors for cancer development. Our study demonstrates an increased incidence of cancer development in patients with empyema, and patients’ age ≥ 60, men, and those with diabetes mellitus and liver cirrhosis showed a higher incidence of developing cancer compared to the general population. The association between such kind of infection and secondary malignancy may be elucidated by further study.

Published
2016

25. Outcome disparities in elder patients with colorectal cancer receiving definitive surgery: A nationwide population-based study in Taiwan.

Author

Liu, Chia-Jen, primary, Chen, San-Chi, additional, Yen, Chueh-Chuan, additional, Teng, Hao Wei, additional, Chen, Ming-Huang, additional, Liu, Chun-Yu, additional, Chao, Ta-Chung, additional, Chiou, Tzeon-Jye, additional, Chen, Po-Min, additional, Liu, Jun-Huang, additional, and Teng, Chung-Jen, additional

Published
2017
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28. Risk of Second Non-Breast Primary Cancer in Male and Female Breast Cancer Patients: A Population-Based Cohort Study

Author

Hung, Man-Hsin, primary, Liu, Chia-Jen, additional, Teng, Chung-Jen, additional, Hu, Yu-Wen, additional, Yeh, Chiu-Mei, additional, Chen, San-Chi, additional, Chien, Sheng-Hsuan, additional, Hung, Yi-Ping, additional, Shen, Cheng-Che, additional, Chen, Tzeng-Ji, additional, Tzeng, Cheng-Hwai, additional, and Liu, Chun-Yu, additional

Published
2016
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30. Incidence of Second Primary Malignancies Following Colorectal Cancer

Author

Lee, Yu-Ting, primary, Liu, Chia-Jen, additional, Hu, Yu-Wen, additional, Teng, Chung-Jen, additional, Tzeng, Cheng-Hwai, additional, Yeh, Chiu-Mei, additional, Chen, Tzeng-Ji, additional, Lin, Jen-Kou, additional, Lin, Chun-Chi, additional, Lan, Yuan-Tzu, additional, Wang, Huann-Sheng, additional, Yang, Shung-Haur, additional, Jiang, Jeng-Kai, additional, Chen, Wei-Shone, additional, Lin, Tzu-Chen, additional, Chang, Shih-Ching, additional, Chen, Ming-Huang, additional, Teng, Hao-Wei, additional, Liu, Jin-Hwang, additional, and Yen, Chueh-Chuan, additional

Published
2015
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37. Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population-based study in Taiwan

Author

Liu, Chia-Jen, primary, Hong, Ying-Chung, additional, Teng, Chung-Jen, additional, Hung, Man-Hsin, additional, Hu, Yu-Wen, additional, Ku, Fan-Chen, additional, Chen, Yung-Tai, additional, Chien, Sheng-Hsuan, additional, Yeh, Chiu-Mei, additional, Chen, Tzeng-Ji, additional, Chiou, Tzeon-Jye, additional, Gau, Jyh-Pyng, additional, and Tzeng, Cheng-Hwai, additional

Published
2014
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41. Delayed Onset Urticaria in Depressive Patients with Bupropion Prescription: A Nationwide Population-Based Study

Author

Hu, Li-Yu, primary, Liu, Chia-Jen, additional, Lu, Ti, additional, Hu, Tsung-Ming, additional, Tsai, Chia-Fen, additional, Hu, Yu-Wen, additional, Shen, Cheng-Che, additional, Chang, Yu-Sheng, additional, Chen, Mu-Hong, additional, Teng, Chung-Jen, additional, Chiang, Huey-Ling, additional, Yeh, Chiu-Mei, additional, Su, Vincent Yi-Fong, additional, Wang, Wei-Shu, additional, Chen, Pan-Ming, additional, Chen, Tzeng-Ji, additional, and Su, Tung-Ping, additional

Published
2013
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42. The Risk of Cancer among Taiwanese Female Registered Nurses: A Nationwide Retrospective Study

Author

Shen, Cheng-Che, primary, Hu, Yu-Wen, additional, Hu, Li-Yu, additional, Perng, Chin-Lin, additional, Su, Tung-Ping, additional, Teng, Chung-Jen, additional, Yen, Sang-Hue, additional, Tzeng, Cheng-Hwai, additional, Chiou, Tzeon-Jye, additional, Yeh, Chiu-Mei, additional, Chen, Tzeng-Ji, additional, Wang, Wei-Shu, additional, Chen, Pan-Ming, additional, and Liu, Chia-Jen, additional

Published
2013
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44. Use of Radioactive Iodine for Thyroid Cancer and Risk of Second Primary Malignancy: A Nationwide Population-Based Study.

Author

Chung-Jen Teng, Yu-Wen Hu, San-Chi Chen, Chiu-Mei Yeh, Huey-Ling Chiang, Tzeng-Ji Chen, Chia-Jen Liu, Teng, Chung-Jen, Hu, Yu-Wen, Chen, San-Chi, Yeh, Chiu-Mei, Chiang, Huey-Ling, Chen, Tzeng-Ji, and Liu, Chia-Jen

Subjects
LEUKEMIA epidemiology, BREAST tumors, COLON tumors, COMPARATIVE studies, KIDNEY tumors, LONGITUDINAL method, LUNG tumors, LYMPHOMAS, RESEARCH methodology, MEDIASTINAL tumors, MEDICAL cooperation, PANCREATIC tumors, PROSTATE tumors, RADIATION doses, RECTUM tumors, RESEARCH, THYROID gland tumors, TIME, EVALUATION research, RELATIVE medical risk, DISEASE incidence, PROPORTIONAL hazards models, SECONDARY primary cancer, ODDS ratio, IODINE radioisotopes
Abstract

Background: Radioactive iodine (RAI) is widely used for the treatment of thyroid cancers. However, information on associations between RAI dose and second primary malignancy (SPM) is lacking.Methods: Patients without antecedent cancer age 20 years or older and newly diagnosed with thyroid cancer were recruited from the Taiwan National Health Insurance database between 1997 and 2010. Standardized incidence ratios (SIRs) for the cancers were calculated to compare the incidence of thyroid cancer with the general population. The association between RAI dosage and cancer development was estimated using time-dependent Cox regression analysis. All statistical tests were two-sided.Results: A total of 692 cases of SPM were identified among 20 235 patients with thyroid cancer. Regarding the latter, 79.7% of the patients were women, the median age was 46 years, and the follow-up period included 134 178 person-years. The SIR for any SPM was 1.41 (95% confidence interval [CI] = 1.31 to 1.52). A statistically significantly higher SIR was observed in leukemia (2.74), non-Hodgkin's lymphoma (2.38), prostate (2.30), lung and mediastinum (1.93), pancreas (1.83), kidney (1.81), breast (1.48), and colon-rectum (1.31) cancers. Cumulative RAI dose (per 30 mCi increase) conferred a strong risk for SPM (adjusted hazard ratio [aHR] = 1.01, 95% CI = 1.01 to 1.02, P < .001) and leukemia (aHR = 1.03, 95% CI = 1.02 to 1.04, P < .001) occurrences. A cumulative RAI dose greater than 150 mCi possessed a statistically significant risk for all cancer combined (aHR = 1.30) and leukemia (aHR = 6.03).Conclusions: An increased risk of SPM was observed for thyroid cancer patients, especially with cumulative RAI doses over 150 mCi. [ABSTRACT FROM AUTHOR]

Published
2016
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45. Thrombotic Complications in Ph'-Negative Myeloproliferative Neoplasms - 10-Year Experience of A Medical Center in Asian Area

Author

Chou, Yi-Sheng, primary, Bai, Ri-Dong, additional, Teng, Chung-Jen, additional, Hong, Ying-Chung, additional, Liu, Chun-Yu, additional, Yu, Yuan-Bin, additional, Hsiao, Liang-Tsai, additional, Liu, Jin-Hwang, additional, Hsu, Hui-Chi, additional, Chiou, Tzeon-Jye, additional, Chen, Po-Min, additional, Tzeng, Cheng-Hwai, additional, and Gau, Jyh-Pyng, additional

Published
2011
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46. Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study

Author

Yang, Ya-Hsu, primary, Lin, Jen-Kou, additional, Chen, Wei-Shone, additional, Lin, Tzu-Chen, additional, Yang, Shung-Haur, additional, Jiang, Jeng-Kai, additional, Chang, Shih-Ching, additional, Lan, Yuan-Tzu, additional, Lin, Chun-Chi, additional, Yen, Chueh-Chuan, additional, Tzeng, Cheng-Hwai, additional, Wang, Wei-Shu, additional, Chiang, Huey-Ling, additional, Teng, Chung-Jen, additional, and Teng, Hao-Wei, additional

Published
2011
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