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6. Reply to Idelevich and Beck

Author

Banerjee, Ritu, Teng, Christine B., Cunningham, Scott A., Ihde, Sherry, Steckelberg, James P., Moriarty, James P., Shah, Nilay D., Mandrekar, Jay, and Patel, Robin

Published
2016
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9. Sustaining Antimicrobial Stewardship in a High–Antibiotic Resistance Setting

Author

Ng, Tat Ming, primary, Heng, Shi Thong, additional, Chua, Boon Hou, additional, Ang, Li Wei, additional, Tan, Sock Hoon, additional, Tay, Hui Lin, additional, Yap, Min Yi, additional, Quek, Jason, additional, Teng, Christine B., additional, Young, Barnaby E., additional, Lin, Ray, additional, Ang, Brenda, additional, Lee, Tau Hong, additional, and Lye, David C., additional

Published
2022
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10. Accuracy of a Rapid Multiplex Polymerase Chain Reaction Plus a Chromogenic Phenotypic Test Algorithm for Detection of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Gram-Negative Bacilli in Positive Blood Culture Bottles

Author

Ong, Sean Wei Xiang, primary, Hon, Pei Yun, additional, Wee, Sharon Syn Hui, additional, Chia, Jonathan Wei Zhong, additional, Mendis, Shehara, additional, Izharuddin, Ezlyn, additional, Lin, Ray Junhao, additional, Chia, Po Ying, additional, Sim, Rees Chin Swee, additional, Chen, Mark I-Cheng, additional, Chow, Angela, additional, Yoong, Joanne, additional, Lye, David Chien, additional, Teng, Christine B, additional, Tambyah, Paul Anantharajah, additional, Banerjee, Ritu, additional, Patel, Robin, additional, De, Partha Pratim, additional, and Vasoo, Shawn, additional

Published
2021
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14. Additional file 1 of Effects of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial prevalence and prescribing in a tertiary hospital in Singapore

Author

Ng, Tat Ming, Sock Hoon Tan, Heng, Shi Thong, Tay, Hui Lin, Yap, Min Yi, Boon Hou Chua, Teng, Christine B., Lye, David C., and Tau Hong Lee

Abstract

Additional file 1. Percentage of Empiric antimicrobial use and prescribing quality indicators for medical, surgical and intensive care patients respectively from 2015 to 2020.

Published
2021
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15. Accuracy of a Rapid Multiplex Polymerase Chain Reaction Plus a Chromogenic Phenotypic Test Algorithm for Detection of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Gram-Negative Bacilli in Positive Blood Culture Bottles.

Author

Ong, Sean Wei Xiang, Hon, Pei Yun, Wee, Sharon Syn Hui, Chia, Jonathan Wei Zhong, Mendis, Shehara, Izharuddin, Ezlyn, Lin, Ray Junhao, Chia, Po Ying, Sim, Rees Chin Swee, Chen, Mark I-Cheng, Chow, Angela, Yoong, Joanne, Lye, David Chien, Teng, Christine B, Tambyah, Paul Anantharajah, Banerjee, Ritu, Patel, Robin, De, Partha Pratim, and Vasoo, Shawn

Subjects
CHROMOGENIC compounds, GRAM-negative bacteria, CARBAPENEM-resistant bacteria, BETA lactamases, POLYMERASE chain reaction, BLOOD testing, GRAM-negative bacterial diseases, DRUG resistance in microorganisms, PHENOTYPES, ALGORITHMS, MICROBIAL sensitivity tests
Abstract

We studied the performance of an algorithm combining multiplex polymerase chain reaction with phenotypic detection of extended-spectrum β-lactamases and carbapenemases directly from positive blood culture bottles in patients with gram-negative bacteremia and found good concordance with routine cultures. Such an algorithm may be a tool to improve time to optimal therapy in patients with gram-negative bacteremia. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Effective Antimicrobial StewaRdship StrategIES (ARIES): Cluster Randomized Trial of Computerized Decision Support System and Prospective Review and Feedback

Author

Heng, Shi Thong, primary, Wong, Joshua, additional, Young, Barnaby, additional, Tay, Hui Lin, additional, Tan, Sock Hoon, additional, Yap, Min Yi, additional, Teng, Christine B, additional, Ang, Brenda, additional, Lee, Tau Hong, additional, Tan, Hui Ling, additional, Lew, Thomas W, additional, Lye, David Chien, additional, and Ng, Tat Ming, additional

Published
2020
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20. Clinical and Molecular Correlates of Escherichia coli Bloodstream Infection from Two Geographically Diverse Centers in Rochester, Minnesota, and Singapore

Author

Mendis, Shehara M., primary, Vasoo, Shawn, additional, Johnston, Brian D., additional, Porter, Stephen B., additional, Cunningham, Scott A., additional, Menon, Sanjay R., additional, Teng, Christine B., additional, De, Partha P., additional, Patel, Robin, additional, Johnson, James R., additional, and Banerjee, Ritu, additional

Published
2018
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24. Reply to Idelevich and Beck

Author

Banerjee, Ritu, primary, Teng, Christine B., additional, Cunningham, Scott A., additional, Ihde, Sherry, additional, Steckelberg, James P., additional, Moriarty, James P., additional, Shah, Nilay D., additional, Mandrekar, Jay, additional, and Patel, Robin, additional

Published
2015
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30. Identification and Susceptibility Testing From Shortly Incubated Cultures Accelerate Blood Culture Diagnostics at No Cost.

Author

Idelevich, Evgeny A., Becker, Karsten, Banerjee, Ritu, Teng, Christine B., Cunningham, Scott A., Ihde, Sherry, Steckelberg, James P., Moriarty, James P., Shah, Nilay D., Mandrekar, Jay, and Patel, Robin

Subjects
POLYMERASE chain reaction, CELL culture
Abstract

A letter to the editor is presented in response to the article "Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing" by R. Banerjee and colleagues published in a 2015 issue.

Published
2016
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32. Guidelines for Antimicrobial Stewardship Training and Practice

Author

Teng, Christine B, primary, Lee, Winnie, additional, Yeo, Chay Leng, additional, Lee, Siok Ying, additional, Ng, Tat Ming, additional, Yeoh, Siang Fei, additional, Lim, Wee Heng, additional, Kwa, Andrea L, additional, Thoon, Koh Cheng, additional, Ooi, Say Tat, additional, Tan, Thean Yen, additional, Hsu, Li Yang, additional, Lye, David C, additional, and Chlebicki, Maciej Piotr, additional

Published
2012
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34. Safety and clinical outcomes of carbapenem de-escalation as part of an antimicrobial stewardship programme in an ESBL-endemic setting.

Author

Kaung Yuan Lew, Tat Ming Ng, Tan, Michelle, Sock Hoon Tan, Ee Ling Lew, Li Min Ling, Brenda Ang, Lye, David, and Teng, Christine B.

Subjects
CARBAPENEMS, BETA lactamases, ENTEROBACTERIACEAE, PHARMACODYNAMICS, ADVERSE health care events
Abstract

Objectives: To evaluate the safety and clinical outcomes of patients who received carbapenem de-escalation as guided by an antimicrobial stewardship programme (ASP) in a setting where ESBL-producing Enterobacteriaceae are endemic. Methods: Patients receiving meropenem or imipenem underwent a prospective ASP review for eligibility for deescalation according to defined institutional guidelines. Patients in whom carbapenem was de-escalated or not de-escalated, representing the acceptance and rejection of the ASP recommendation, respectively, were compared. The primary outcome was the clinical success rate; secondary outcomes included the 30 day readmission and mortality rates, the duration of carbapenem therapy, the incidence of adverse drug reactions due to antimicrobials, the acquisition of carbapenem-resistant Gram-negative bacteria and the occurrence of Clostridium difficile-associated diarrhoea (CDAD). Results: The de-escalation recommendations for 300 patients were evaluated; 204 (68.0%) were accepted. The patient demographics and disease severity were similar. The clinical success rates were similar [de-escalated versus not de-escalated, 183/204 (89.7%) versus 85/96 (88.5%), P = 0.84], as was the survival at hospital discharge [173/204 (84.8%) versus 79/96 (82.3%), P = 0.58]. In the de-escalated group, the duration of carbapenem therapy was shorter (6 versus 8 days, P< 0.001), the rate of adverse drug reactions was lower [11/204 (5.4%) versus 12/96 (12.5%), P = 0.037], there was less diarrhoea [9/204 (4.4%) versus 12/96 (12.5%), P = 0.015], there was a lower incidence of carbapenem-resistant Acinetobacter baumannii acquisition [4/204 (2.0%) versus 7/96 (7.3%), P = 0.042] and there was a lower incidence of CDAD [2/204 (1.0%) versus 4/96 (4.2%), P=0.081]. Conclusions: This study suggests that the ASP-guided de-escalation of carbapenems led to comparable clinical success, fewer adverse effects and a lower incidence of the development of resistance. This approach is safe and practicable, and should be a key component of an ASP. [ABSTRACT FROM AUTHOR]

Published
2015
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35. Vancomycin monotherapy vs. combination therapy for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia.

Author

Seah, Jonathan, Lye, David C, Ng, Tat-Ming, Krishnan, Prabha, Choudhury, Saugata, and Teng, Christine B

Subjects
VANCOMYCIN, METHICILLIN-resistant staphylococcus aureus, BACTEREMIA, DRUG resistance in microorganisms, STAPHYLOCOCCUS aureus infections
Abstract

The article presents a study which examined the use of combination therapy and vancomycin monotherapy in patients with persistent methicillin-resistant Staphylococcus aureus (pMRSA) bacteremia. The researchers used information on patient demographics, clinical and treatment records and laboratory assessment and microbiological tests. The thirty-day (30-d) mortality and other outcomes such as microbiologic clearance and clinical improvement for the patients are evaluated.

Published
2013
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36. Clinical and Molecular Correlates of Escherichia coliBloodstream Infection from Two Geographically Diverse Centers in Rochester, Minnesota, and Singapore

Author

Mendis, Shehara M., Vasoo, Shawn, Johnston, Brian D., Porter, Stephen B., Cunningham, Scott A., Menon, Sanjay R., Teng, Christine B., De, Partha P., Patel, Robin, Johnson, James R., and Banerjee, Ritu

Abstract

Escherichia colibacteremia is caused mainly by sequence type complex 131 (STc131) and two clades within its fluoroquinolone-resistance-associated H30 subclone, H30R1 and H30Rx. We examined clinical and molecular correlates of E. colibacteremia in two geographically distinct centers.

Published
2018
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