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1. TIP60 is required for tumorigenesis in non‐small cell lung cancer

Author

Shibahara, Daisuke, Akanuma, Naoki, Kobayashi, Ikei S, Heo, Eunyoung, Ando, Mariko, Fujii, Masanori, Jiang, Feng, Prin, P Nicholas, Pan, Gilbert, Wong, Kwok‐Kin, Costa, Daniel B, Bararia, Deepak, Tenen, Daniel G, Watanabe, Hideo, and Kobayashi, Susumu S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biotechnology, Cancer, Lung Cancer, Genetics, Lung, 2.1 Biological and endogenous factors, Aetiology, Animals, Mice, Carcinogenesis, Carcinoma, Non-Small-Cell Lung, Cell Transformation, Neoplastic, Histone Acetyltransferases, Lung Neoplasms, Humans, artemisinin, KAT5, lung cancer, TGM5, TIP60, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Histone modifications play crucial roles in transcriptional activation, and aberrant epigenetic changes are associated with oncogenesis. Lysine (K) acetyltransferases 5 (TIP60, also known as KAT5) is reportedly implicated in cancer development and maintenance, although its function in lung cancer remains controversial. Here we demonstrate that TIP60 knockdown in non-small cell lung cancer cell lines decreased tumor cell growth, migration, and invasion. Furthermore, analysis of a mouse lung cancer model with lung-specific conditional Tip60 knockout revealed suppressed tumor formation relative to controls, but no apparent effects on normal lung homeostasis. RNA-seq and ChIP-seq analyses of inducible TIP60 knockdown H1975 cells relative to controls revealed transglutaminase enzyme (TGM5) as downstream of TIP60. Investigation of a connectivity map database identified several candidate compounds that decrease TIP60 mRNA, one that suppressed tumor growth in cell culture and in vivo. In addition, TH1834, a TIP60 acetyltransferase inhibitor, showed comparable antitumor effects in cell culture and in vivo. Taken together, suppression of TIP60 activity shows tumor-specific efficacy against lung cancer, with no overt effect on normal tissues. Our work suggests that targeting TIP60 could be a promising approach to treating lung cancer.

Published
2023

2. APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Author

Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L., Zhang, Xiaoming, Brandão, Wesley, Margeta, Milica A., Schroeder, Caitlin, Sivanathan, Kisha N., Silveira, Sebastian, Gauthier, Christian, Mallah, Dania, Pitts, Kristen M., Durao, Ana, Herron, Shawn, Shorey, Hannah, Cheng, Yiran, Barry, Jen-Li, Krishnan, Rajesh K., Wakelin, Sam, Rhee, Jared, Yung, Anthony, Aronchik, Michael, Wang, Chao, Jain, Nimansha, Bao, Xin, Gerrits, Emma, Brouwer, Nieske, Deik, Amy, Tenen, Daniel G., Ikezu, Tsuneya, Santander, Nicolas G., McKinsey, Gabriel L., Baufeld, Caroline, Sheppard, Dean, Krasemann, Susanne, Nowarski, Roni, Eggen, Bart J. L., Clish, Clary, Tanzi, Rudolph E., Madore, Charlotte, Arnold, Thomas D., Holtzman, David M., and Butovsky, Oleg

Published
2023
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3. Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia

Author

Ong, Kelly Ooi Kee, Mok, Michelle Meng Huang, Niibori-Nambu, Akiko, Du, Linsen, Yanagida, Masatoshi, Wang, Chelsia Qiuxia, Bahirvani, Avinash Govind, Chin, Desmond Wai Loon, Koh, Cai Ping, Ng, King Pan, Yamashita, Namiko, Jacob, Bindya, Yokomizo, Tomomasa, Takizawa, Hitoshi, Matsumura, Takayoshi, Suda, Toshio, Lau, Jie-ying Amelia, Tan, Tuan Zea, Mori, Seiichi, Yang, Henry, Iwasaki, Masayuki, Minami, Takashi, Asou, Norio, Sun, Qiao-Yang, Ding, Ling-Wen, Koeffler, H. Phillip, Tenen, Daniel G., Shimizu, Ritsuko, Yamamoto, Masayuki, Ito, Yoshiaki, Kham, Shirley Kow Yin, Yeoh, Allen Eng-Juh, Chng, Wee Joo, and Osato, Motomi

Published
2024
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5. Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

Author

Koh, Cai Ping, Bahirvani, Avinash Govind, Wang, Chelsia Qiuxia, Yokomizo, Tomomasa, Ng, Cherry Ee Lin, Du, Linsen, Tergaonkar, Vinay, Voon, Dominic Chih-Cheng, Kitamura, Hiroaki, Hosoi, Hiroki, Sonoki, Takashi, Michelle, Mok Meng Huang, Tan, Lii Jye, Niibori-Nambu, Akiko, Zhang, Yi, Perkins, Archibald S., Hossain, Zakir, Tenen, Daniel G., Ito, Yoshiaki, Venkatesh, Byrappa, and Osato, Motomi

Published
2023
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6. Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

Author

Guo, Mingrui, Chan, Tim Hon Man, Zhou, Qiling, An, Omer, Li, Ying, Song, Yangyang, Tan, Zi Hui, Ng, Vanessa Hui En, Peramangalam, Philomina Sona, Tan, Zhi Qing, Cao, Xinang, Iwanaga, Eisaku, Matsuoka, Masao, Ooi, Melissa, Jen, Wei Ying, Koh, Liang Piu, Chan, Esther, Tan, Lip Kun, Goh, Yufen, Wang, Wilson, Koh, Bryan T. H., Chun, Chan Ming, Fullwood, Melissa J., Chng, Wee Joo, Osato, Motomi, Pulikkan, John Anto, Yang, Henry, Chen, Leilei, and Tenen, Daniel G.

Published
2023
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9. Author Correction: Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia

Author

Bassal, Mahmoud A., Samaraweera, Saumya E., Lim, Kelly, Benard, Brooks A., Bailey, Sheree, Kaur, Satinder, Leo, Paul, Toubia, John, Thompson-Peach, Chloe, Nguyen, Tran, Maung, Kyaw Ze Ya, Casolari, Debora A., Iarossi, Diana G., Pagani, Ilaria S., Powell, Jason, Pitson, Stuart, Natera, Siria, Roessner, Ute, Lewis, Ian D., Brown, Anna L., Tenen, Daniel G., Robinson, Nirmal, Ross, David M., Majeti, Ravindra, Gonda, Thomas J., Thomas, Daniel, and D’Andrea, Richard J.

Published
2022
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12. Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia

Author

Bassal, Mahmoud A., Samaraweera, Saumya E., Lim, Kelly, Benard, Brooks A., Bailey, Sheree, Kaur, Satinder, Leo, Paul, Toubia, John, Thompson-Peach, Chloe, Nguyen, Tran, Maung, Kyaw Ze Ya, Casolari, Debora A., Iarossi, Diana G., Pagani, Ilaria S., Powell, Jason, Pitson, Stuart, Natera, Siria, Roessner, Ute, Lewis, Ian D., Brown, Anna L., Tenen, Daniel G., Robinson, Nirmal, Ross, David M., Majeti, Ravindra, Gonda, Thomas J., Thomas, Daniel, and D’Andrea, Richard J.

Published
2022
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13. Metabolic alterations mediated by STAT3 promotes drug persistence in CML

Author

Patel, Sweta B., Nemkov, Travis, Stefanoni, Davide, Benavides, Gloria A., Bassal, Mahmoud A., Crown, Brittany L., Matkins, Victoria R., Camacho, Virginia, Kuznetsova, Valeriya, Hoang, Ashley T., Tenen, Danielle E., Wolock, Samuel L., Park, Jihye, Ying, Li, Yue, Zongliang, Chen, Jake Y., Yang, Henry, Tenen, Daniel G., Ferrell, Paul Brent, Lu, Rui, Darley-Usmar, Victor, D’Alessandro, Angelo, Bhatia, Ravi, and Welner, Robert S.

Published
2021
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14. Supplementary Table 10 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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15. FIGURE 1 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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16. Supplementary Figure S4 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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17. FIGURE 3 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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18. FIGURE 5 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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19. Supplementary Table 9 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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20. FIGURE 2 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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21. Supplementary Table 7 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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22. Supplementary Table 3 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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23. Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, additional, Alfieri, Roberta, additional, Maymi, Valerie A., additional, Pandell, Nicole, additional, Csizmadia, Eva, additional, Zhang, Junyan, additional, Weetall, Marla, additional, Branstrom, Art, additional, Braccini, Giulia, additional, Cabrera San Millán, Eva, additional, Storti, Barbara, additional, Bizzarri, Ranieri, additional, Kocher, Olivier, additional, Daniela Sanchez Bassères, Daniela S., additional, Welner, Robert S., additional, Magli, Maria Cristina, additional, Merelli, Ivan, additional, Clohessy, John G., additional, Ali, Azhar, additional, Tenen, Daniel G., additional, and Levantini, Elena, additional

Published
2024
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24. Supplementary Table 8 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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25. Supplementary Table 5 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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26. Supplementary Table 2 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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27. Supplementary Table 4 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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28. FIGURE 4 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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29. Data from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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30. Supplementary Table 6 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment

Author

Maroni, Giorgia, primary, Krishnan, Indira, primary, Alfieri, Roberta, primary, Maymi, Valerie A., primary, Pandell, Nicole, primary, Csizmadia, Eva, primary, Zhang, Junyan, primary, Weetall, Marla, primary, Branstrom, Art, primary, Braccini, Giulia, primary, Cabrera San Millán, Eva, primary, Storti, Barbara, primary, Bizzarri, Ranieri, primary, Kocher, Olivier, primary, Daniela Sanchez Bassères, Daniela S., primary, Welner, Robert S., primary, Magli, Maria Cristina, primary, Merelli, Ivan, primary, Clohessy, John G., primary, Ali, Azhar, primary, Tenen, Daniel G., primary, and Levantini, Elena, primary

Published
2024
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31. Targeting transcription factors through an IMiD independent zinc finger domain

Author

Liu, Bee Hui, primary, Liu, Miao, additional, Radhakrishnan, Sridhar, additional, Jaladanki, Chaitanya Kumar, additional, Gao, Chong, additional, Tang, Jing Ping, additional, Kumari, Kalpana, additional, Go, Mei Lin, additional, Vu, Kim Anh L., additional, Seo, Hyuk-Soo, additional, Song, Kijun, additional, Tian, Xi, additional, Feng, Li, additional, Tan, Justin L., additional, Bassal, Mahmoud A., additional, Arthanari, Haribabu, additional, Qi, Jun, additional, Dhe-Paganon, Sirano, additional, Fan, Hao, additional, Tenen, Daniel G., additional, and Chai, Li, additional

Published
2024
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33. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., Ummarino, Simone, Zhang, Yanzhou, Ebralidze, Alexander K., Bassal, Mahmoud A., Nguyen, Tuan M., Heller, Gerwin, Coffey, Rory, Tenen, Danielle E., van der Kouwe, Emiel, Fabiani, Emiliano, Gurnari, Carmelo, Wu, Chan-Shuo, Angarica, Vladimir Espinosa, Yang, Henry, Chen, Sisi, Zhang, Hong, Thurm, Abby R., Marchi, Francisco, Levantini, Elena, Staber, Philipp B., Zhang, Pu, Voso, Maria Teresa, Pandolfi, Pier Paolo, Kobayashi, Susumu S., Chai, Li, Di Ruscio, Annalisa, and Tenen, Daniel G.

Published
2021
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36. APOE4 impairs microglia‐astrocyte response in Alzheimer’s disease by inducing TGFβ‐mediated checkpoints

Author

Butovsky, Oleg, primary, Yin, Zhuoran, additional, Rosenzweig, Neta, additional, Kleemann, Kilian, additional, Zhang, Xiaoming, additional, Brandao, Wesley N, additional, Margeta, Milica, additional, Schroeder, Caitlin M, additional, Silveira, Sebastian, additional, Gauthier, Christian, additional, Mallah, Dania, additional, Pitts, Kristen, additional, Durao, Ana, additional, Herron, Shawn, additional, Shorey, Hannah, additional, Cheng, Yiran, additional, Barry, Jen‐Li, additional, Wakelin, Sam, additional, Rhee, Jared, additional, Yung, Anthony, additional, Aronchik, Michael, additional, Wang, Chao, additional, Jain, Nimansha, additional, Bao, Xin, additional, Gerrits, Emma, additional, Brouwer, Nieske, additional, Deik, Amy, additional, Tenen, Daniel G., additional, Ikezu, Tsuneya, additional, Santander, Nicolas G., additional, McKinsey, Gabriel L., additional, Baufeld, Caroline, additional, Sheppard, Dean, additional, Krasemann, Susanne, additional, Eggen, Bart, additional, Clish, Clary, additional, Tanzi, Rudolph E., additional, Madore, Charlotte, additional, Arnold, Thomas D., additional, and Holtzman, David M., additional

Published
2023
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37. APOE4 impairs Microglia ‐ Astrocyte Crosstalk in Alzheimer Disease

Author

Kleemann, Kilian, primary, Rosenzweig, Neta, additional, Yin, Zhuoran, additional, Zhang, Xiaoming, additional, Brandao, Wesley N, additional, Margeta, Milica, additional, Schroeder, Caitlin M, additional, Silveira, Sebastian, additional, Gauthier, Christian, additional, Mallah, Dania, additional, Pitts, Kristen, additional, Herron, Shawn, additional, Shorey, Hannah, additional, Aronchik, Michael, additional, Wang, Chao, additional, Jain, Nimansha, additional, Bao, Xin, additional, Brouwer, Nieske, additional, Baufeld, Caroline, additional, Krasemann, Susanne, additional, Eggen, Bart, additional, Clish, Clary, additional, Tanzi, Rudolph E., additional, Madore, Charlotte, additional, Wakelin, Sam, additional, Rhee, Jared, additional, Cheng, Yiran, additional, Barry, Jen‐Li, additional, Yung, Anthony, additional, Gerrits, Emma, additional, Deik, Amy, additional, Tenen, Daniel G., additional, Santander, Nicolas G., additional, Ikezu, Tsuneya, additional, McKinsey, Gabriel L., additional, Sheppard, Dean, additional, Arnold, Thomas D., additional, Durao, Ana, additional, Holtzman, David M., additional, and Butovsky, Oleg, additional

Published
2023
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39. Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Author

Maroni, Giorgia, Bassal, Mahmoud A., Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A., Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castaño, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E., Fox, Sam, Levy, Rachel D., Meyerovitz, Claire V., Tramontozzi, Peter J., Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Bassères, Daniela S., Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M., Welner, Robert S., Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G., Ali, Azhar, Tenen, Daniel G., and Levantini, Elena

Published
2021
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44. Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice

Author

Komeno, Yukiko, Yan, Ming, Matsuura, Shinobu, Lam, Kentson, Lo, Miao-Chia, Huang, Yi-Jou, Tenen, Daniel G, Downing, James R, and Zhang, Dong-Er

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Stem Cell Research - Nonembryonic - Non-Human, Genetics, Stem Cell Research, Hematology, 2.1 Biological and endogenous factors, Aetiology, Animals, Base Sequence, Cells, Cultured, Core Binding Factor Alpha 2 Subunit, Exons, Gene Expression Regulation, HEK293 Cells, Hematopoiesis, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Protein Isoforms, RNA Splice Sites, Sequence Homology, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology, Biochemistry and cell biology, Cardiovascular medicine and haematology, Paediatrics
Abstract

RUNX1 is an important transcription factor for hematopoiesis. There are multiple alternatively spliced isoforms of RUNX1. The best known isoforms are RUNX1a from use of exon 7A and RUNX1b and c from use of exon 7B. RUNX1a has unique functions due to its lack of C-terminal regions common to RUNX1b and c. Here, we report that the ortholog of human RUNX1a was only found in primates. Furthermore, we characterized 3 Runx1 isoforms generated by exon 6 alternative splicing. Runx1bEx6(-) (Runx1b without exon 6) and a unique mouse Runx1bEx6e showed higher colony-forming activity than the full-length Runx1b (Runx1bEx6(+)). They also facilitated the transactivation of Runx1bEx6(+). To gain insight into in vivo functions, we analyzed a knock-in (KI) mouse model that lacks isoforms Runx1b/cEx6(-) and Runx1bEx6e. KI mice had significantly fewer lineage-Sca1(+)c-Kit(+) cells, short-term hematopoietic stem cells (HSCs) and multipotent progenitors than controls. In vivo competitive repopulation assays demonstrated a sevenfold difference of functional HSCs between wild-type and KI mice. Together, our results show that Runx1 isoforms involving exon 6 support high self-renewal capacity in vitro, and their loss results in reduction of the HSC pool in vivo, which underscore the importance of fine-tuning RNA splicing in hematopoiesis.

Published
2014

46. SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis

Author

L. Vu, Kim Anh, primary, Kumari, Kalpana, additional, Liu, Bee Hui, additional, Gao, Chong, additional, Li, Feng, additional, Tang, Jing Ping, additional, Maddalo, Danilo, additional, Auld, Douglas S., additional, Casalena, Dominick E., additional, Tian, Xi, additional, Liu, Miao, additional, Bassal, Mahmoud A., additional, Moein, Shiva, additional, Iakovleva, Viktoriia, additional, Tan, Justin L., additional, Stein, Alicia J., additional, Zhou, Qiling, additional, Fischer, Patrick D., additional, Sigua, Logan H., additional, Qi, Jun, additional, Arthanari, Haribabu, additional, Tenen, Daniel G., additional, and Chai, Li, additional

Published
2023
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