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11 results on '"Ten Heuvel, Alexandra"'

1. Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing

Author

Cohen, Danielle, Hondelink, Liesbeth M., Solleveld-Westerink, Nienke, Uljee, Sandra M., Ruano, Dina, Cleton-Jansen, Anne-Marie, von der Thüsen, Jan H., Ramai, S. Rajen S., Postmus, Pieter E., Graadt van Roggen, Jacob F., Hoppe, Bart P.C., Clahsen, Pieter C., Maas, Klaartje W., Ahsmann, Els J.M., ten Heuvel, Alexandra, Smedts, Frank, van Rossem, Ronald N., and van Wezel, Tom

Published
2020
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3. Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy

Author

de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, Deneer, Vera H M, de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, and Deneer, Vera H M

Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, disabling side effect in non-small cell lung cancer (NSCLC) patients treated with platinum-based therapy. There is increasing evidence for associations between genetic variants and susceptibility to CIPN. The aim of this study was to further explore genetic risk factors for CIPN by investigating previously reported genetic associations. Methods: A multicenter prospective follow-up study (PGxLUNG, NTR NL5373610015) in NSCLC patients (stage II-IV) treated with first-line platinum-based (cisplatin or carboplatin) chemotherapy was conducted. Clinical evaluation of neuropathy (CTCAE v4.03) was performed at baseline and before each cycle (four cycles, every three weeks) of chemotherapy and at three and six months after treatment initiation. The relationship between 34 single nucleotide polymorphisms (SNPs) in 26 genes and any grade (grade ≥ 1) and severe (grade ≥ 2) CIPN was assessed by using univariate and multivariate logistic regression modelling. Results: In total, 320 patients were included of which 26.3% (n = 84) and 8.1% (n = 26) experienced any grade and severe CIPN, respectively. The GG-genotype (rs879207, A > G) of TRPV1, a gene expressed in peripheral sensory neurons, was observed in 11.3% (n = 36) of the patients and associated with an increased risk of severe neuropathy (OR 5.2, 95%CI 2.1–12.8, adjusted p-value 0.012). A quarter (25%, n = 9/36) of the patients with the GG-genotype developed severe neuropathy compared to 6% (n = 17/282) of the patients with the AG- or AA-genotype. Multivariate logistic regression analysis showed statistically significant associations between the GG-genotype (ORadj 4.7, 95%CI 1.8–12.3) and between concomitant use of paclitaxel (ORadj 7.2, 95%CI 2.5–21.1) and severe CIPN. Conclusions: Patients with the GG-genotype (rs879207) of TRPV1 have an almost 5-fold higher risk of developing severe neuropathy when treated with platinum-based therapy. Future st

Published
2023

4. Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy

Author

Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, Deneer, Vera H M, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, and Deneer, Vera H M

Published
2023

5. Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy

Author

Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Apotheek Klinische Farmacie, de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, Deneer, Vera H M, Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Apotheek Klinische Farmacie, de Jong, Corine, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke S, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Egberts, Toine C G, and Deneer, Vera H M

Published
2023

6. The association between skeletal muscle measures and chemotherapy‐induced toxicity in non‐small cell lung cancer patients

Author

de Jong, Corine, Chargi, Najiba, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A, Devriese, Lot A, Huitema, Alwin D R, Egberts, Toine C G, de Bree, Remco, Deneer, Vera H M, Pharmacoepidemiology and Clinical Pharmacology, and Afd Pharmacoepi & Clinical Pharmacology

Subjects
Male, Lung Neoplasms, Antineoplastic Agents, Middle Aged, Body composition, Chemotherapy-induced toxicity, Skeletal muscle mass, Non-small cell lung cancer, Carcinoma, Non-Small-Cell Lung, Physiology (medical), Humans, Female, Orthopedics and Sports Medicine, Prospective Studies, Muscle, Skeletal, Platinum-based chemotherapy, Follow-Up Studies
Abstract

BACKGROUND: Chemotherapy-induced toxicities frequently occur in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. Low skeletal muscle mass (SMM) has been associated with a higher incidence of toxicities for several types of cancers and cytostatics. The aim of this study was to evaluate the association between skeletal muscle measures and chemotherapy-induced toxicity in a large cohort of NSCLC patients. METHODS: A multicentre prospective follow-up study (PGxLUNG, NTR number NL5373610015) in NSCLC patients was conducted. Included were patients diagnosed with NSCLC (stage II-IV) treated with first-line platinum-based (cisplatin or carboplatin) chemotherapy of whom pretreatment imaging was available. Skeletal muscle area (SMA) segmentation was performed on abdominal imaging at the level of the third lumbar vertebra (L3). SMA at the level of L3 was corrected for squared height (m2 ) to yield the lumbar skeletal muscle mass index (LSMI). Skeletal muscle density (SMD) was calculated as the mean Hounsfield Unit (HU) of the segmented SMA. SMM and SMD were categorized as low, intermediate, and high, based on LSMI and mean HU tertiles, respectively. Chemotherapy-induced toxicity was scored using CTCAE v4.03 and categorized into haematological (anaemia, leukocytopenia, neutropenia, and thrombocytopenia), non-haematological (nephrotoxicity, neurotoxicity, and esophagitis), and dose-limiting toxicity (DLT) (treatment switch, delay, de-escalation, discontinuation, or hospitalization). The relationship between SMM, SMD, and toxicities was assessed with logistic regression modelling taking into account potential confounders like gender and body mass index (BMI). RESULTS: In total, 297 patients (male n = 167, median age 64 years) were included. Haematological toxicity grade 3/4 was experienced in 36.6% (n = 108) of the patients, 24.6% (n = 73) experienced any non-haematological toxicity grade ≥2, and 55.6% (n = 165) any DLT. Multivariate logistic regression analysis showed that low SMM (ORadj 2.41, 95% CI 1.31-4.45, P = 0.005) and age at diagnosis >65 years (ORadj 1.76, 95% CI 1.07-2.90, P = 0.025) were statistically significantly associated with overall haematological toxicity grade 3/4. No statistically significant associations were found between low SMM or low SMD and non-haematological toxicities. Low SMM (ORadj 2.23, 95% CI 1.23-4.04, P = 0.008) and high SMD (ORadj 0.41, 95% CI 0.23-0.74, P = 0.003) were statistically significantly associated with a higher respectively lower risk of DLT. CONCLUSIONS: Non-small cell lung cancer patients with pretreatment low SMM are at significant higher risk for haematological toxicities grade 3/4 and DLT. NSCLC patients with high SMD are at significant lower risk for DLT. Further studies should be aimed to investigate whether platinum dosing based on skeletal muscle measurements and/or improvement of pretreatment SMM/SMD could reduce the risk of toxicity without compromising efficacy.

Published
2022
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8. The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients

Author

Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A, Devriese, Lot A, Huitema, Alwin D R, Egberts, Toine C G, de Bree, Remco, Deneer, Vera H M, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J M, van Haarlem, Simone W A, van der Meer, Femke, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A, Devriese, Lot A, Huitema, Alwin D R, Egberts, Toine C G, de Bree, Remco, and Deneer, Vera H M

Published
2022

9. The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients

Author

Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Researchgr. Systems Radiology, Circulatory Health, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Apotheek O&O&O, Brain, Child Health, MS Hoofd-Hals Chirurgische Oncologie, Apotheek Klinische Farmacie, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J.M., van Haarlem, Simone W.A., van der Meer, Femke, van Lindert, Anne S.R., ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A., Devriese, Lot A., Huitema, Alwin D.R., Egberts, Toine C.G., de Bree, Remco, Deneer, Vera H.M., Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Researchgr. Systems Radiology, Circulatory Health, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Apotheek O&O&O, Brain, Child Health, MS Hoofd-Hals Chirurgische Oncologie, Apotheek Klinische Farmacie, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J.M., van Haarlem, Simone W.A., van der Meer, Femke, van Lindert, Anne S.R., ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A., Devriese, Lot A., Huitema, Alwin D.R., Egberts, Toine C.G., de Bree, Remco, and Deneer, Vera H.M.

Published
2022

10. Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study

Author

Zazuli, Zulfan, primary, de Jong, Corine, additional, Xu, Wei, additional, Vijverberg, Susanne J. H., additional, Masereeuw, Rosalinde, additional, Patel, Devalben, additional, Mirshams, Maryam, additional, Khan, Khaleeq, additional, Cheng, Dangxiao, additional, Ordonez-Perez, Bayardo, additional, Huang, Shaohui, additional, Spreafico, Anna, additional, Hansen, Aaron R., additional, Goldstein, David P., additional, de Almeida, John R., additional, Bratman, Scott V., additional, Hope, Andrew, additional, Knox, Jennifer J., additional, Wong, Rebecca K. S., additional, Darling, Gail E., additional, Kitchlu, Abhijat, additional, van Haarlem, Simone W. A., additional, van der Meer, Femke, additional, van Lindert, Anne S. R., additional, ten Heuvel, Alexandra, additional, Brouwer, Jan, additional, Ross, Colin J. D., additional, Carleton, Bruce C., additional, Egberts, Toine C. G., additional, Herder, Gerarda J. M., additional, Deneer, Vera H. M., additional, Maitland-van der Zee, Anke H., additional, and Liu, Geoffrey, additional

Published
2021
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11. Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study

Author

Apotheek Onderzoek, Apotheek Opleiding, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Brain, Child Health, Regenerative Medicine and Stem Cells, Apotheek Klinische Farmacie, Zazuli, Zulfan, de Jong, Corine, Xu, Wei, Vijverberg, Susanne J H, Masereeuw, Rosalinde, Patel, Devalben, Mirshams, Maryam, Khan, Khaleeq, Cheng, Dangxiao, Ordonez-Perez, Bayardo, Huang, Shaohui, Spreafico, Anna, Hansen, Aaron R, Goldstein, David P, de Almeida, John R, Bratman, Scott V, Hope, Andrew, Knox, Jennifer J, Wong, Rebecca K S, Darling, Gail E, Kitchlu, Abhijat, van Haarlem, Simone W A, van der Meer, Femke, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Ross, Colin J D, Carleton, Bruce C, Egberts, Toine C G, Herder, Gerarda J M, Deneer, Vera H M, Maitland-van der Zee, Anke H, Liu, Geoffrey, Apotheek Onderzoek, Apotheek Opleiding, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Brain, Child Health, Regenerative Medicine and Stem Cells, Apotheek Klinische Farmacie, Zazuli, Zulfan, de Jong, Corine, Xu, Wei, Vijverberg, Susanne J H, Masereeuw, Rosalinde, Patel, Devalben, Mirshams, Maryam, Khan, Khaleeq, Cheng, Dangxiao, Ordonez-Perez, Bayardo, Huang, Shaohui, Spreafico, Anna, Hansen, Aaron R, Goldstein, David P, de Almeida, John R, Bratman, Scott V, Hope, Andrew, Knox, Jennifer J, Wong, Rebecca K S, Darling, Gail E, Kitchlu, Abhijat, van Haarlem, Simone W A, van der Meer, Femke, van Lindert, Anne S R, Ten Heuvel, Alexandra, Brouwer, Jan, Ross, Colin J D, Carleton, Bruce C, Egberts, Toine C G, Herder, Gerarda J M, Deneer, Vera H M, Maitland-van der Zee, Anke H, and Liu, Geoffrey

Published
2021

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