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Photobiomodulation (PBM) has demonstrated positive effects on bone healing after fracture. This case report describes a skateboard-related shoulder anterior dislocation with Bankart and Hill-Sachs lesions. After a non-invasive reduction, the patient received conservative treatment with PBM. PBM was started on the accident day and continued daily for 30 days, followed by bi-weekly irradiation for 33 months. In the initial 30 days, the patient’s pain decreased, and the shoulder function was recovered with no pain, swelling, or bruising. On day 28, there was a reduction in edema compared to the initial injury and a full shoulder recovery for daily and sports activities. Physical examinations confirmed shoulder joint stability and the images at 33 months demonstrated Hill-Sachs lesion healing and significant Bankart lesion repair. In conclusion, PBM can induce recovery, alleviate pain, and facilitate functional rehabilitation. Additional clinical trials are required to validate the efficacy of this complementary therapy.

Starting with theoretical reflections, the issue delves into design experiences across the past, present, and future, illustrating the significant role of timber technology in the Alpine region. In an interview with Hermann Kaufmann, a leading figure in timber construction both locally in Vorarlberg and internationally, we gain insights into the future of timber construction technology from a historical and biographical standpoint. Kaufmann, with his extensive background in the timber construction industry, having been actively involved in workshops and worksites since childhood due to his family’s background in carpentry, provides a valuable perspective on exploring the potential and challenges of timber construction technology. One crucial consideration is the urgent need to decarbonise the built environment in response to the ongoing climate and environmental crisis. Drawing from Kaufmann’s expertise, the discussion also addresses the interplay between timber as a natural material and the increasingly stringent regulations shaping the field of architecture.

At the end of the Eighties the global recognition of Alpine architecture coincided with a profound shift in architectural media, particularly journalism. Photographic images played an increasing role in the reproduction of architecture in journals. In this overview, the important position of some sacred works is discussed, as they competed for the covers of renowned magazines, ultimately becoming icons of the new Alpine architecture. The article analyses the reasons behind this success by studying three emblematic cases in the Central Alps: the Chapels Sogn Benedetg by Peter Zumthor, St. Nepomuk by Christian Kerez in the Graubünden, and the Salgenreute Chapel by Bernardo Bader in Vorarlberg.

Fatigue in air traffic management (ATM) is a well-recognized safety concern. International organizations like ICAO and EASA have responded by advocating for fatigue risk management systems (FRMSs). EU Regulation 2017/373, implemented in January 2020, mandates specific requirements for air traffic service providers (ANSPs) regarding controller fatigue, stress, and rostering practices. These regulations are part of broader safety management protocols. Despite ongoing efforts to raise awareness about fatigue in ATC, standardized operational requirements remain elusive. To address this gap, Eurocontrol recently published “Guidelines on fatigue management in ATC rostering systems” (23 April 2024). This initiative aims to facilitate the adoption of common fatigue management standards across operations. However, neither EU Regulation 2017/373 nor existing documentation provides definitive rostering criteria. ANSPs typically derive these criteria from a combination of scientific research, best practices, historical data, and legal and operational constraints. Assessing and monitoring fatigue in the real-world ATC setting is complex. The multifaceted nature of fatigue makes it difficult to study, as it is influenced by many factors including sleep quality, circadian rhythms, psychosocial stressors, individual differences, and environmental conditions. Long-term studies are often required to fully understand these complex interactions. This paper presents two case studies that attempt to create an evidence-based protocol for fatigue risk monitoring in ATC operations. These studies utilize a non-invasive approach and collect multidimensional data. The cases involved en-route and tower (TWR) controllers from different ATC centers. The results highlight the importance of fatigue assessment in ATC and shed light on the challenges of implementing fatigue monitoring systems within operational environments.

Background: To compare photodynamic therapy and the use of probiotics in reducing halitosis assessed through gas chromatography and microbiome analysis. Methods: Participants aged from 18 to 25 years showing sulfide (SH2) ≥ 112 ppb on gas chromatography were selected. They were divided into four treatment groups: Group 1—Tongue Scraping; Group 2—Antimicrobial Photodynamic Therapy (aPDT); Group 3—Probiotics; and Group 4—Antimicrobial Photodynamic Therapy (aPDT) and Probiotics. The halimetry process was performed before, immediately after the treatments, and 7 days, 14 days, and 30 days after the initial collection. The collections for later microbiological analysis were made along with the halimetry for microbiome analysis. Results: Treatment with aPDT or probiotics under these experimental conditions was not able to change the bacteria present in the biofilm of the tongue. Conclusions: More research is needed to know the behavior of the oral microbiome in the presence of halitosis and the effectiveness of new treatments.

ObjectiveTo assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children.Materials and methodsFifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of ≥ 3 on portable breath meter) Breath Alert™ (Tanita Corporation®-Japan), were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The hypothesis of normality in the data was discarded by the Shapiro-Wilk test (p < 0.05) and for statistical analysis the Wilcoxon and Mann-Whitney tests were used.ResultsA significant difference was found between the pre-treatment reading and all other readings (p < 0.05) in both groups, suggesting the effectiveness of the proposed treatments. No significant difference was found between the post-treatment reading and two follow-up readings, suggesting the maintenance of the effect of treatment over time (p > 0.05). However, significant differences were found between groups for all post-treatment assessments (p < 0.0001 for all comparisons), indicating greater effectiveness with aPDT. No association was found between the initial reading and the presence of coated tongue.ConclusionAntimicrobial photodynamic therapy using annatto and blue LED proved to be a viable therapeutic option for the treatment of halitosis in mouth-breathing children.

ObjectiveThis study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) and the use of probiotics on the treatment of halitosis.MethodsFifty-two participants, aged from 18 to 25 years, exhaling sulfhydride (H2S) ≥ 112 ppb were selected. They were allocated into 4 groups (n = 13): Group 1: tongue scraper; Group 2: treated once with aPDT; Group 3: probiotic capsule containing Lactobacillus salivarius WB21 (6.7 x 108 CFU) and xylitol (280mg), 3 times a day after meals, for 14 days; Group 4: treated once with aPDT and with the probiotic capsule for 14 days. Halimetry with gas chromatography (clinical evaluation) and microbiological samples were collected from the dorsum of the tongue before and after aPDT, as well as after 7, 14, and 30 days. The clinical data failed to follow a normal distribution; therefore, comparisons were made using the Kruskal-Wallis test (independent measures) and Friedman ANOVA (dependent measures) followed by appropriate posthoc tests, when necessary. For the microbiological data, seeing as the data failed to follow a normal distribution, the Kruskal-Wallis rank sum test was performed with Dunn's post-test. The significance level was α = 0.05.ResultsClinical results (halimetry) showed an immediate significant reduction in halitosis with aPDT (p = 0.0008) and/or tongue scraper (p = 0.0006). Probiotics showed no difference in relation to the initial levels (p = 0.7530). No significant differences were found in the control appointments. The amount of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were not altered throughout the analysis (p = 0.1616, p = 0.2829 and p = 0.2882, respectively).ConclusionThere was an immediate clinical reduction of halitosis with aPDT and tongue scraping, but there was no reduction in the number of bacteria throughout the study, or differences in the control times, both in the clinical and microbiological results. New clinical trials are necessary to better assess the tested therapies.Trial registrationClinical Trials NCT03996044.

Photobiomodulation is a safe option for controlling pain, edema, and trismus when applied postoperatively in third molar surgery. However, administration prior to surgery has been under-explored. This study aims to explore the effectiveness of pre-emptive photobiomodulation in reducing postoperative edema in impacted lower third molar extractions. Two groups of healthy individuals undergoing tooth extraction will be randomly assigned: Control group receiving pre-emptive corticosteroid and simulated photobiomodulation, and Photobiomodulation Group receiving intraoral low-intensity laser and extraoral LED cluster application. The primary outcome will be postoperative edema after 48 h. The secondary outcomes will be pain, trismus dysphagia, and analgesic intake (paracetamol). These outcomes will be assessed at baseline as well as two and seven days after surgery. Adverse effects will be recorded. Data will be presented as means ± SD and a p-value < 0.05 will be indicative of statistical significance.

Introduction Molar incisor hypomineralisation (MIH) is a qualitative defect of enamel development that occurs in the mineralisation phase. MIH affects one or more permanent molars and, occasionally, permanent incisors. The aim of the proposed study is to evaluate the clinical effect of antimicrobial photodynamic therapy (aPDT) on permanent teeth with MIH through decontamination and sensitivity control.Methods and analysis Patients from 8 to 12 years of age with permanent molars will be randomly allocated to three groups. Group 1: selective chemical–mechanical removal of carious dentinal tissue around the walls of the cavity with Papacárie Duo and a curette followed by the application of aPDT and deproteinisation with Papacárie Duo; group 2: selective removal of carious dentinal tissue around the walls of the cavity with a curette, followed by the application of aPDT and deproteinisation with a 5% sodium hypochlorite solution; group 3: selective removal of carious dentinal tissue using a curette. The selected teeth must have a carious lesion in the dentin and posteruptive enamel breakdown on one or more surfaces with an indication for clinical restorative treatment. The teeth will subsequently be restored using a mixed technique with resin-modified glass ionomer cement and bulk-fill composite resin. The data will be submitted to descriptive statistical analysis. Associations with age and sex will be tested using either the χ2 test or Fisher’s exact test. Pearson’s correlation coefficients will be calculated to determine the strength of correlations between variables. Comparisons of the microbiological results (colony-forming units) will be performed using analysis of variance and the Kruskal-Wallis test. Kaplan-Meier survival analysis will be performed to assess the performance of the restorations.Ethics and dissemination This protocol has been approved by the Human Research Ethics Committee of Nove de Julho University (certificate number: 61027522.0.0000.5511/approval date: 23 August 2022). The findings will be published in a peer-reviewed journal.Trial registration number NCT05443035.

Abstract Background Alternatively to conventional treatments, chemo-mechanical caries removal agents can be used. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana is being researched for application in aPDT. This protocol aims to determine the effectiveness of aPDT with Bixa orellana extract in deep caries lesions. Methods A total of 160 teeth with deep occlusal dental caries will be selected and divided into 4 groups: G1 - control group (Caries removal with a low-speed drill); G2 - Partial Caries Removal with Papacarie™ (Fórmula e Ação, São Paulo, SP, Brazil); G3 - Partial Caries Removal with Papacarie™ and application Bixa orellana extract (20%) (Fórmula e Ação, São Paulo, SP, Brazil); G4 - Partial Caries Removal with Papacarie™ and application Bixa orellana extract (20%) with LED (Valo Cordless Ultradent®, South Jordan, UT, USA) (aPDT). After treatment, all the teeth will be restored with glass ionomer cement and followed up clinically and radiographically, with evaluations at immediately, 1 week, and 1, 3, 6, and 12 months. Dentin samples before and after treatment will be analyzed microbiologically. The efficacy of treatments will be assessed with microbiological (colony-forming units, before and after carious tissue removal), radiographic (integrity of the periapical area and eventual changes in the radiolucent zones), and clinical examinations (retention of the restorative material in the cavity and occurrence of secondary caries), as well as with the time required for the procedures and the need for anesthesia during the procedures. In case data distribution is normal, analysis of variance (ANOVA) will be used for both the dependent and independent variables. In case the data distribution is not normal, the Friedman test will be used for the dependent variables. For independent variables, the Kruskal-Wallis test will be used. Discussion Procedures using aPDT have been developed for the treatment of dental caries, but there are few controlled clinical trials in the literature confirming its efficacy. Trial registration This protocol is registered at ClinicalTrials.gov under the number NCT05236205 and it was first posted on 01/21/2022 and last updated on 05/10/2022.

Knowledge of possible cyber threats as well as awareness of appropriate security measures plays a crucial role in the ability of individuals to not only discriminate between an innocuous versus a dangerous cyber event, but more importantly to initiate appropriate cybersecurity behaviors. The purpose of this study was to construct a Cybersecurity Awareness INventory (CAIN) to be used as an instrument to assess users’ cybersecurity knowledge by providing a proficiency score that could be correlated with cyber security behaviors. A scale consisting of 46 items was derived from ISO/IEC 27032. The questionnaire was administered to a sample of college students (N = 277). Based on cybersecurity behaviors reported to the research team by the college’s IT department, each participant was divided into three groups according to the risk reports they received in the past nine months (no risk, low risk, and medium risk). The ANOVA results showed a statistically significant difference in CAIN scores between those in the no risk and medium-risk groups; as expected, CAIN scores were lower in the medium-risk group. The CAIN has the potential to be a useful assessment tool for cyber training programs as well as future studies investigating individuals’ vulnerability to cyberthreats.

Background: in patients undergoing percutaneous coronary interventions (PCI), radial access should be favoured over femoral access as it reduces the risk of vascular complications and bleeding. Furthermore, a preventive role of radial access in the occurrence of acute kidney injury (AKI), mainly mediated by the reduction of bleeding and cholesterol crystal embolization into renal circulation, has been investigated in several studies, yielding conflicting results. Methods: we designed a retrospective study to appraise the effect of the use of a vascular access site on the occurrence of AKI in a cohort of 633 patients with acute myocardial infarction treated by PCI at our centre from 2018 to 2020. Results: after propensity score adjustment, radial access was associated with a reduced, albeit statistically not significant, incidence of AKI (14.7% vs. 21.0%; p = 0.06) and major bleeding (12.5% vs. 18.7%; p = 0.04) as compared to femoral access. At multivariate analysis, femoral access was an independent predictor of AKI, together with in-hospital occurrence of BARC 3–5 bleeding, Killip class >1 at presentation, female gender, baseline eGFR Conclusions: although limited by the observational design, our study supports the hypothesis that radial access may exert a protective role on the occurrence of AKI in patients with acute myocardial infarction undergoing PCI.

Introduction The objective is to investigate the effect of antimicrobial photodynamic therapy (aPDT) mediated by erythrosine and a blue light-emitting diode (LED) in the reduction of bacteria in dental biofilm.Methods and analysis This clinical trial will be conducted with 30 patients who have biofilm, but without the presence of periodontal pockets, and who are being treated at the Dental Clinic of Universidade Metropolitana de Santos. A split-mouth model will be used (n=30), with group 1 control (conventional treatment) and group 2 (conventional treatment and aPDT). The bicarbonate jet will be used to remove dental biofilm in both groups. The treatment will be carried out in one session. aPDT will be performed before cleaning/prophylaxis, only in group 2. Participants will rinse with the photosensitiser erythrosine (diluted to 1 mM) for 1 min of pre-irradiation time, so that the drug can stain all the bacterial biofilm. Then, the D-2000 LED (DMC) will be applied, emitting at a wavelength of ʎ=470 nm, radiant power of 1000 mW, irradiance of 0.532 W/cm2 and radiant exposure of 63.8 J/cm2. Irradiation will be performed until the biofilm of the cervical region is illuminated for 2 min/point (4 cm2). The microbiological examination will be performed from samples of supragingival biofilm collected from the gingival sulcus. Collection will be performed in each experimental site before irradiation, immediately after the irradiation procedure and after the prophylaxis. Colony-forming units will be counted and the data will be submitted for statistical analysis for comparison of pretreatment and post-treatment results and between groups (conventional X aPDT).Ethics and dissemination This study has been approved by the Ethics Committee of Universidade Metropolitana de Santos under process number 66984123.0.0000.5509. Results will be published in peer-reviewed journals and will be presented at conferences.Trial registration number NCT05805761.

Introduction Photobiomodulation has been widely used as a complementary treatment for dentin hypersensitivity, with reports of clinical success. However, the literature offers only one study, in which photobiomodulation was used for the treatment of sensitivity in molars with molar incisor hypomineralisation (MIH). The aim of the proposed study is to determine whether photobiomodulation enhances the results of treatment with glass ionomer sealant on molars with MIH that present sensitivity.Methods and analysis The study involves 50 patients from 6 to 12 years of age that will be randomly allocated in two groups. Group 1 (control group) (n=25): toothpaste with a concentration of fluoride ≤1000 ppm two times a day, glass ionomer sealant and sham low-level laser (LLL) and group 2 (n=25): toothpaste with a concentration of fluoride ≤1000 ppm two times a day, glass ionomer sealant and active LLL. The evaluations will involve MIH record, Simplified Oral Hygiene Index (OHI), Schiff Cold Air Sensitivity Scale (SCASS) and visual analogue scale (VAS) before the procedure. Immediately after the procedure, the hypersensitivity index (SCASS/VAS) will be registered. Records of OHI and SCASS/VAS will be registered after 48 hours as well as 1 month after the procedure. The persistence of the sealant will also be registered. It is expected that by the second consultation, a decrease in sensitivity will be observed due to the treatments received in the two groups.Ethics and dissemination This protocol has been approved by the local medical ethical committee (certificate: CEUCU 220516). The findings will be published in a peer-reviewed journal.Trial registration number NCT05370417.

Usable security involves designing security measures that accommodate users’ needs and behaviors. Balancing usability and security poses challenges: the more secure the systems, the less usable they will be. On the contrary, more usable systems will be less secure. Numerous studies have addressed this balance. These studies, spanning psychology and computer science/engineering, contribute diverse perspectives, necessitating a systematic review to understand strategies and findings in this area. This systematic literature review examined articles on usable security from 2005 to 2022. A total of 55 research studies were selected after evaluation. The studies have been broadly categorized into four main clusters, each addressing different aspects: (1) usability of authentication methods, (2) helping security developers improve usability, (3) design strategies for influencing user security behavior, and (4) formal models for usable security evaluation. Based on this review, we report that the field’s current state reveals a certain immaturity, with studies tending toward system comparisons rather than establishing robust design guidelines based on a thorough analysis of user behavior. A common theoretical and methodological background is one of the main areas for improvement in this area of research. Moreover, the absence of requirements for Usable security in almost all development contexts greatly discourages implementing good practices since the earlier stages of development.

Objective: To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children. Materials and methods: Fifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of ≥ 3 on portable breath meter) Breath Alert™ (Tanita Corporation®-Japan), were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The hypothesis of normality in the data was discarded by the Shapiro-Wilk test (p < 0.05) and for statistical analysis the Wilcoxon and Mann-Whitney tests were used. Results: A significant difference was found between the pre-treatment reading and all other readings (p < 0.05) in both groups, suggesting the effectiveness of the proposed treatments. No significant difference was found between the post-treatment reading and two follow-up readings, suggesting the maintenance of the effect of treatment over time (p > 0.05). However, significant differences were found between groups for all post-treatment assessments (p < 0.0001 for all comparisons), indicating greater effectiveness with aPDT. No association was found between the initial reading and the presence of coated tongue. Conclusion: Antimicrobial photodynamic therapy using annatto and blue LED proved to be a viable therapeutic option for the treatment of halitosis in mouth-breathing children. [ABSTRACT FROM AUTHOR]

The maintenance of the deciduous tooth until its physiological exfoliation occurs is one of the main objectives of pediatric dentistry. Endodontic treatment in deciduous teeth resulting from carious or traumatic lesions with pulpal involvement is often necessary and we often find it difficult to perform it, due to the difficult control of the child, the internal anatomy of the root canals, and root resorptions. The non-instrumental endodontic treatment technique (NIET) associated with antimicrobial drugs has advantages such as shorter chair time and less complexity than the conventional technique in which root canal instrumentation is performed. The aim of this study is to carry out a controlled and randomized clinical trial to compare the effectiveness of (NIET) in primary teeth associated with the use of two obturator pastes. One hundred and twenty necrotic deciduous teeth of children aged between 3 and 6 years will be selected; and the teeth will be divided into two groups. In Group 1 and Group 2, root canals will not be instrumented, just irrigated and filled with the respective pastes, antibiotic (CTZ) and iodoform (Guedes-Pinto). Presence of fistula and mobility will be clinically evaluated. The evaluations will be carried out in both groups on the day of treatment and in periods of 1, 3 and 6 months after treatment. For the main outcome, the tooth will be the unit of analysis and the Kaplan-Meier test will be performed to estimate the survival rates of the included teeth. For comparison between the two groups, Student's t test or Mann-Whitney test will be performed, depending on the normality of the data. In addition, Poisson regression analyzes will be carried out, in order to allow the evaluation of the influence of some variables on the results. For all analyses, the significance value will be adjusted to 5%. Trial registration: NCT04587089 in ClinicalTrials.gov. Approval date: May 15, 2023.

Production buildings and infrastructures, being the man-made marks left on the Alpine landscape, have historically had a different value than they have today. For a short period during modernity, they were used as advertising elements to represent the progress of Alpine territories and were later ignored by the architectural discourse, which failed to understand their cultural, environmental and ecological values. These buildings were often the subject of that “spatial separation” between the energy production and the energy consumption areas which contributed, even in the Alpine territory, to the construction of industrial areas devoid of any character or attractiveness. It is only since the end of the last century that the growing environmental, social, cultural, and political awareness, as well as the emergence of major environmental and climate crises have contributed to the realisation that the quality architectural project is of fundamental importance in the construction of industrial and productive buildings. After a brief introduction, the article illustrates some examples of contemporary architecture for production in the Alps, arranged functionally. There are agricultural buildings, small workshops, facilities for the production and distribution of electrical and thermal energy, waste treatment plants, and office buildings.

Procrastination may be seen as the outcome of a learning history of delaying the onset of task execution and its completion, both in terms of time and effort. In this study, we examined the performance of 55 university students who carried out two writing tasks consisting of summarizing two academic papers, each within a different time slot (i.e., five vs. three days to complete). The two assignments were part of the class activity and were perceived by participants as homogeneous in terms of text appreciation and difficulty, therefore making the two conditions comparable. The Pure Procrastination Scale was used to categorize subjects as high and low procrastinators, and to compare their performances. Results show that students who report more procrastination behaviors tend to increase their productivity as the deadline approaches, while low procrastinators are more productive throughout the time at their disposal, with peak activity during the intermediate day. Such a strategy was consistent across two deadlines (five vs. three days), and the difference between the two subgroups can be ascribed to the task-oriented coping style, which seems to be lacking in high-procrastinators.

Background: This study aimed to evaluate the electrical activity of the rectus femoris, tibialis anterior, and lateral gastrocnemius muscles during the sit-to-stand task and functional mobility after a neurofunctional physiotherapy protocol associated with PBM. Methods: Twenty-five children were randomly allocated to either Active PBM + physiotherapy (n = 13) or PBM sham + physiotherapy (n = 12). PBM was carried out with a LED device (850 nm, 25 J, 50 s per point and 200 mW) at four points over the area with absence of a spiny process. Both groups completed a twelve-week supervised program with two weekly 45–60 min sessions. Pre-training and post-training assessments involved the Pediatric Evaluation of Disability Inventory (PEDI). Muscle activity was assessed using portable electromyography (BTS Engineering) and the electrodes were positioned on the lateral gastrocnemius, anterior tibialis, and rectus femoris muscles. The RMS data were recorded and analyzed. Results: After 24 sessions of the treatment protocol, improvements were found in the PEDI score. The participants presented greater independence in performing the tasks, requiring less assistance from their caregivers. More significant electrical activity was found in the three muscles evaluated between the rest period and execution of the sit-to-stand tasks, both in the more compromised or less compromised lower limbs. Conclusion: Neurofunctional physiotherapy with or without PBM improved functional mobility and electrical muscle activity in children with myelomeningocele.

Objective: This study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) and the use of probiotics on the treatment of halitosis. Methods: Fifty-two participants, aged from 18 to 25 years, exhaling sulfhydride (H2S) ≥ 112 ppb were selected. They were allocated into 4 groups (n = 13): Group 1: tongue scraper; Group 2: treated once with aPDT; Group 3: probiotic capsule containing Lactobacillus salivarius WB21 (6.7 x 108 CFU) and xylitol (280mg), 3 times a day after meals, for 14 days; Group 4: treated once with aPDT and with the probiotic capsule for 14 days. Halimetry with gas chromatography (clinical evaluation) and microbiological samples were collected from the dorsum of the tongue before and after aPDT, as well as after 7, 14, and 30 days. The clinical data failed to follow a normal distribution; therefore, comparisons were made using the Kruskal-Wallis test (independent measures) and Friedman ANOVA (dependent measures) followed by appropriate posthoc tests, when necessary. For the microbiological data, seeing as the data failed to follow a normal distribution, the Kruskal-Wallis rank sum test was performed with Dunn's post-test. The significance level was α = 0.05. Results: Clinical results (halimetry) showed an immediate significant reduction in halitosis with aPDT (p = 0.0008) and/or tongue scraper (p = 0.0006). Probiotics showed no difference in relation to the initial levels (p = 0.7530). No significant differences were found in the control appointments. The amount of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were not altered throughout the analysis (p = 0.1616, p = 0.2829 and p = 0.2882, respectively). Conclusion: There was an immediate clinical reduction of halitosis with aPDT and tongue scraping, but there was no reduction in the number of bacteria throughout the study, or differences in the control times, both in the clinical and microbiological results. New clinical trials are necessary to better assess the tested therapies. Trial registration: Clinical Trials NCT03996044. [ABSTRACT FROM AUTHOR]

Photobiomodulation is a safe option for controlling pain, edema, and trismus when applied postoperatively in third molar surgery. However, administration prior to surgery has been under-explored. This study aims to explore the effectiveness of pre-emptive photobiomodulation in reducing postoperative edema in impacted lower third molar extractions. Two groups of healthy individuals undergoing tooth extraction will be randomly assigned: Control group receiving pre-emptive corticosteroid and simulated photobiomodulation, and Photobiomodulation Group receiving intraoral low-intensity laser and extraoral LED cluster application. The primary outcome will be postoperative edema after 48 h. The secondary outcomes will be pain, trismus dysphagia, and analgesic intake (paracetamol). These outcomes will be assessed at baseline as well as two and seven days after surgery. Adverse effects will be recorded. Data will be presented as means ± SD and a p-value < 0.05 will be indicative of statistical significance. [ABSTRACT FROM AUTHOR]

Fatigue in air traffic management (ATM) is a well-recognized safety concern. International organizations like ICAO and EASA have responded by advocating for fatigue risk management systems (FRMSs). EU Regulation 2017/373, implemented in January 2020, mandates specific requirements for air traffic service providers (ANSPs) regarding controller fatigue, stress, and rostering practices. These regulations are part of broader safety management protocols. Despite ongoing efforts to raise awareness about fatigue in ATC, standardized operational requirements remain elusive. To address this gap, Eurocontrol recently published "Guidelines on fatigue management in ATC rostering systems" (23 April 2024). This initiative aims to facilitate the adoption of common fatigue management standards across operations. However, neither EU Regulation 2017/373 nor existing documentation provides definitive rostering criteria. ANSPs typically derive these criteria from a combination of scientific research, best practices, historical data, and legal and operational constraints. Assessing and monitoring fatigue in the real-world ATC setting is complex. The multifaceted nature of fatigue makes it difficult to study, as it is influenced by many factors including sleep quality, circadian rhythms, psychosocial stressors, individual differences, and environmental conditions. Long-term studies are often required to fully understand these complex interactions. This paper presents two case studies that attempt to create an evidence-based protocol for fatigue risk monitoring in ATC operations. These studies utilize a non-invasive approach and collect multidimensional data. The cases involved en-route and tower (TWR) controllers from different ATC centers. The results highlight the importance of fatigue assessment in ATC and shed light on the challenges of implementing fatigue monitoring systems within operational environments. [ABSTRACT FROM AUTHOR]

Background: To compare photodynamic therapy and the use of probiotics in reducing halitosis assessed through gas chromatography and microbiome analysis. Methods: Participants aged from 18 to 25 years showing sulfide (SH2) ≥ 112 ppb on gas chromatography were selected. They were divided into four treatment groups: Group 1—Tongue Scraping; Group 2—Antimicrobial Photodynamic Therapy (aPDT); Group 3—Probiotics; and Group 4—Antimicrobial Photodynamic Therapy (aPDT) and Probiotics. The halimetry process was performed before, immediately after the treatments, and 7 days, 14 days, and 30 days after the initial collection. The collections for later microbiological analysis were made along with the halimetry for microbiome analysis. Results: Treatment with aPDT or probiotics under these experimental conditions was not able to change the bacteria present in the biofilm of the tongue. Conclusions: More research is needed to know the behavior of the oral microbiome in the presence of halitosis and the effectiveness of new treatments. [ABSTRACT FROM AUTHOR]