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This paper aims to offer a feminist, Latin-American reading on the gender representations that constitute the discourse on the US war on drugs in Latin America. Drawing upon the feminist literature on international security, this article explores some of the nuances of the US war-on-drugs discourse when it comes to gender. It argues that, although a gendered discourse has been constantly present in US official discourse, it has visibly changed in character as the USA's antidrug policies became increasingly internationalized, militarized, and oriented by a 'supply-side approach.' Once deployed through the feminization of drug consumption as a moral degradation of the nation's social body, US war-on-drugs discourse perceptibly changed to encompass a process of hyper-masculinization of the figure of the US drug warrior, supported by subordinate masculinities and femininities represented by the subaltern, feminized Latin American drug warriors, and the ruthless, hyper-aggressive drug lords. Ultimately, the gender(ed) cartographies of the USA's war-on-drugs discourse work as conditions of possibility for framing the war on drugs as the only 'solution' to the 'drug problem' and reaffirm the incessant search for sovereignty that has as its ultimate goal the total control, domination and vigilance of human interaction with psychoactive substances: attributes of a hegemonic state masculinity par excellence. Through gendered (in)security performances, the state defends not only its 'physical' borders from external threats, but also its own frontiers of possibility. [ABSTRACT FROM AUTHOR]

Objectives: To assess the molecular profile of follicular cell-derived thyroid carcinomas (FCDTCs) and correlate the identified mutations with the clinical and pathological features of the affected patients., Materials and Methods: Cross-sectional study of tumor samples from 100 adult patients diagnosed with FCDTC between 2010 and 2019. The patients' clinical and pathological data were collected. Genomic DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) tumors using the ReliaPrep FFPE gDNA Miniprep System. Genotyping of target genomic regions ( KRAS, NRAS, BRAF, EGFR , and PIK3CA ) was performed using the AmpliSeq panel, while sequencing was performed on the iSeq 100 platform., Results: The patients' mean age was 39 years. In all, 82% of the tumors were classic papillary thyroid carcinomas. Overall, 54 (54%) tumor samples yielded satisfactory results on next-generation sequencing (NGS), of which 31 harbored mutations. BRAF gene mutations were the most frequent, with the BRAF V600E mutation present in 10 tumors. Seven tumors had BRAF NON-V600E mutations not previously described in FCDTCs (G464E, G464R, G466E, S467L, G469E, G596D, and the T599Ifs*10 deletion) but described in other types of cancer ( i.e. , skin/melanoma, lung, colorectal, and others). One tumor had a previously reported BRAF A598V mutation. EGFR gene mutations were found in 16 (29%) and KRAS or NRAS alterations in 8 (14%) of the 54 tumors analyzed., Conclusion: We described herein seven non-hotspot/novel variants in the BRAF gene, highlighting their potential role in expanding our understanding of FCDTC genetics., Competing Interests: Disclosure: no potential conflict of interest relevant to this article was reported.