1,594 results on '"Telfer P"'
Search Results
2. BOLD v4: A Centralized Bioinformatics Platform for DNA-based Biodiversity Data
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Ratnasingham, Sujeevan, Wei, Catherine, Chan, Dean, Agda, Jireh, Agda, Josh, Ballesteros-Mejia, Liliana, Boutou, Hamza Ait, Bastami, Zak Mohammad El, Ma, Eddie, Manjunath, Ramya, Rea, Dana, Ho, Chris, Telfer, Angela, McKeowan, Jaclyn, Rahulan, Miduna, Steinke, Claudia, Dorsheimer, Justin, Milton, Megan, and Hebert, Paul D. N.
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Computer Science - Databases ,Quantitative Biology - Quantitative Methods - Abstract
BOLD, the Barcode of Life Data System, supports the acquisition, storage, validation, analysis, and publication of DNA barcodes, activities requiring the integration of molecular, morphological, and distributional data. Its pivotal role in curating the reference library of DNA barcodes, coupled with its data management and analysis capabilities, make it a central resource for biodiversity science. It enables rapid, accurate identification of specimens and also reveals patterns of genetic diversity and evolutionary relationships among taxa. Launched in 2005, BOLD has become an increasingly powerful tool for advancing understanding of planetary biodiversity. It currently hosts 17 million specimen records and 14 million barcodes that provide coverage for more than a million species from every continent and ocean. The platform has the long-term goal of providing a consistent, accurate system for identifying all species of eukaryotes. BOLD's integrated analytical tools, full data lifecycle support, and secure collaboration framework distinguish it from other biodiversity platforms. BOLD v4 brought enhanced data management and analysis capabilities as well as novel functionality for data dissemination and publication. Its next version will include features to strengthen its utility to the research community, governments, industry, and society-at-large.
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- 2024
3. The Implementation-Effectiveness of a Mindfulness-Based Retreat for Mothers of Pediatric Heart Transplant Recipients: A Pilot Hybrid Mixed Methods Study
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Anthony, Samantha J., Selkirk, Enid K., Lin, Jia, Mitchell, Joanna, Robertson, Taylor, Donma, Ani Jamyang, Seifert-Hansen, Mirna, Telfer, Heather, and Ahola Kohut, Sara
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- 2024
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- View/download PDF
4. Global arthropod beta-diversity is spatially and temporally structured by latitude.
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Seymour, Mathew, Roslin, Tomas, deWaard, Jeremy R, Perez, Kate HJ, D'Souza, Michelle L, Ratnasingham, Sujeevan, Ashfaq, Muhammad, Levesque-Beaudin, Valerie, Blagoev, Gergin A, Bukowski, Belén, Cale, Peter, Crosbie, Denise, Decaëns, Thibaud, deWaard, Stephanie L, Ekrem, Torbjørn, El-Ansary, Hosam O, Evouna Ondo, Fidèle, Fraser, David, Geiger, Matthias F, Hajibabaei, Mehrdad, Hallwachs, Winnie, Hanisch, Priscila E, Hausmann, Axel, Heath, Mark, Hogg, Ian D, Janzen, Daniel H, Kinnaird, Margaret, Kohn, Joshua R, Larrivée, Maxim, Lees, David C, León-Règagnon, Virginia, Liddell, Michael, Lijtmaer, Darío A, Lipinskaya, Tatsiana, Locke, Sean A, Manjunath, Ramya, Martins, Dino J, Martins, Marlúcia B, Mazumdar, Santosh, McKeown, Jaclyn TA, Anderson-Teixeria, Kristina, Miller, Scott E, Milton, Megan A, Miskie, Renee, Morinière, Jérôme, Mutanen, Marko, Naik, Suresh, Nichols, Becky, Noguera, Felipe A, Novotny, Vojtech, Penev, Lyubomir, Pentinsaari, Mikko, Quinn, Jenna, Ramsay, Leah, Rochefort, Regina, Schmidt, Stefan, Smith, M Alex, Sobel, Crystal N, Somervuo, Panu, Sones, Jayme E, Staude, Hermann S, St Jaques, Brianne, Stur, Elisabeth, Telfer, Angela C, Tubaro, Pablo L, Wardlaw, Tim J, Worcester, Robyn, Yang, Zhaofu, Young, Monica R, Zemlak, Tyler, Zakharov, Evgeny V, Zlotnick, Bradley, Ovaskainen, Otso, and Hebert, Paul DN
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Animals ,Arthropods ,Biodiversity ,Geography ,Spatio-Temporal Analysis ,Biological Sciences ,Ecology ,Evolutionary Biology ,Life Below Water ,Biological sciences ,Biomedical and clinical sciences - Abstract
Global biodiversity gradients are generally expected to reflect greater species replacement closer to the equator. However, empirical validation of global biodiversity gradients largely relies on vertebrates, plants, and other less diverse taxa. Here we assess the temporal and spatial dynamics of global arthropod biodiversity dynamics using a beta-diversity framework. Sampling includes 129 sampling sites whereby malaise traps are deployed to monitor temporal changes in arthropod communities. Overall, we encountered more than 150,000 unique barcode index numbers (BINs) (i.e. species proxies). We assess between site differences in community diversity using beta-diversity and the partitioned components of species replacement and richness difference. Global total beta-diversity (dissimilarity) increases with decreasing latitude, greater spatial distance and greater temporal distance. Species replacement and richness difference patterns vary across biogeographic regions. Our findings support long-standing, general expectations of global biodiversity patterns. However, we also show that the underlying processes driving patterns may be regionally linked.
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- 2024
5. ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES): protocol for a randomised controlled trial of remotely delivered fitness training for brain health
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Brodtmann, Amy, Billett, Alex, Telfer, Rachael, Adkins, Kim, White, Laura, McCambridge, Laura J. E., Burrell, Louise M., Thijs, Vincent, Kramer, Sharon, Werden, Emilio, Cardoso, Barbara R., Pase, Matthew, Hung, Stanley Hughwa, Churilov, Leonid, Bernhardt, Julie, Hayward, Kathryn, and Johnson, Liam
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- 2024
- Full Text
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6. Cancer diagnosis after emergency presentations in people with mental health and substance use conditions: a national cohort study
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Cunningham, Ruth, Stanley, James, Imlach, Fiona, Haitana, Tracy, Lockett, Helen, Every-Palmer, Susanna, Clark, Mau Te Rangimarie, Lacey, Cameron, Telfer, Kendra, and Peterson, Debbie
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- 2024
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7. The bii4africa dataset of faunal and floral population intactness estimates across Africa’s major land uses
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Clements, Hayley S., Do Linh San, Emmanuel, Hempson, Gareth, Linden, Birthe, Maritz, Bryan, Monadjem, Ara, Reynolds, Chevonne, Siebert, Frances, Stevens, Nicola, Biggs, Reinette, De Vos, Alta, Blanchard, Ryan, Child, Matthew, Esler, Karen J., Hamann, Maike, Loft, Ty, Reyers, Belinda, Selomane, Odirilwe, Skowno, Andrew L., Tshoke, Tshegofatso, Abdoulaye, Diarrassouba, Aebischer, Thierry, Aguirre-Gutiérrez, Jesús, Alexander, Graham J., Ali, Abdullahi H., Allan, David G., Amoako, Esther E., Angedakin, Samuel, Aruna, Edward, Avenant, Nico L., Badjedjea, Gabriel, Bakayoko, Adama, Bamba-kaya, Abraham, Bates, Michael F., Bates, Paul J. J., Belmain, Steven R., Bennitt, Emily, Bradley, James, Brewster, Chris A., Brown, Michael B., Brown, Michelle, Bryja, Josef, Butynski, Thomas M., Carvalho, Filipe, Channing, Alan, Chapman, Colin A., Cohen, Callan, Cords, Marina, Cramer, Jennifer D., Cronk, Nadine, Cunneyworth, Pamela M. K., Dalerum, Fredrik, Danquah, Emmanuel, Davies-Mostert, Harriet T., de Blocq, Andrew D., De Jong, Yvonne A., Demos, Terrence C., Denys, Christiane, Djagoun, Chabi A. M. S., Doherty-Bone, Thomas M., Drouilly, Marine, du Toit, Johan T., Ehlers Smith, David A., Ehlers Smith, Yvette C., Eiseb, Seth J., Fashing, Peter J., Ferguson, Adam W., Fernández-García, José M., Finckh, Manfred, Fischer, Claude, Gandiwa, Edson, Gaubert, Philippe, Gaugris, Jerome Y., Gibbs, Dalton J., Gilchrist, Jason S., Gil-Sánchez, Jose M., Githitho, Anthony N., Goodman, Peter S., Granjon, Laurent, Grobler, J. Paul, Gumbi, Bonginkosi C., Gvozdik, Vaclav, Harvey, James, Hauptfleisch, Morgan, Hayder, Firas, Hema, Emmanuel M., Herbst, Marna, Houngbédji, Mariano, Huntley, Brian J., Hutterer, Rainer, Ivande, Samuel T., Jackson, Kate, Jongsma, Gregory F. M., Juste, Javier, Kadjo, Blaise, Kaleme, Prince K., Kamugisha, Edwin, Kaplin, Beth A., Kato, Humphrey N., Kiffner, Christian, Kimuyu, Duncan M., Kityo, Robert M., Kouamé, N’goran G., Kouete T, Marcel, le Roux, Aliza, Lee, Alan T. K., Lötter, Mervyn C., Lykke, Anne Mette, MacFadyen, Duncan N., Macharia, Gacheru P., Madikiza, Zimkitha J. K., Mahlaba, Themb’alilahlwa A. M., Mallon, David, Mamba, Mnqobi L., Mande, Claude, Marchant, Rob A., Maritz, Robin A., Markotter, Wanda, McIntyre, Trevor, Measey, John, Mekonnen, Addisu, Meller, Paulina, Melville, Haemish I., Mganga, Kevin Z., Mills, Michael G. L., Minnie, Liaan, Missoup, Alain Didier, Mohammad, Abubakr, Moinde, Nancy N., Moise, Bakwo Fils E., Monterroso, Pedro, Moore, Jennifer F., Musila, Simon, Nago, Sedjro Gilles A., Namoto, Maganizo W., Niang, Fatimata, Nicolas, Violaine, Nkenku, Jerry B., Nkrumah, Evans E., Nono, Gonwouo L., Norbert, Mulavwa M., Nowak, Katarzyna, Obitte, Benneth C., Okoni-Williams, Arnold D., Onongo, Jonathan, O’Riain, M. Justin, Osinubi, Samuel T., Parker, Daniel M., Parrini, Francesca, Peel, Mike J. S., Penner, Johannes, Pietersen, Darren W., Plumptre, Andrew J., Ponsonby, Damian W., Porembski, Stefan, Power, R. John, Radloff, Frans G. T., Rambau, Ramugondo V., Ramesh, Tharmalingam, Richards, Leigh R., Rödel, Mark-Oliver, Rollinson, Dominic P., Rovero, Francesco, Saleh, Mostafa A., Schmiedel, Ute, Schoeman, M. Corrie, Scholte, Paul, Serfass, Thomas L., Shapiro, Julie Teresa, Shema, Sidney, Siebert, Stefan J., Slingsby, Jasper A., Sliwa, Alexander, Smit-Robinson, Hanneline A., Sogbohossou, Etotepe A., Somers, Michael J., Spawls, Stephen, Streicher, Jarryd P., Swanepoel, Lourens, Tanshi, Iroro, Taylor, Peter J., Taylor, William A., te Beest, Mariska, Telfer, Paul T., Thompson, Dave I., Tobi, Elie, Tolley, Krystal A., Turner, Andrew A., Twine, Wayne, Van Cakenberghe, Victor, Van de Perre, Frederik, van der Merwe, Helga, van Niekerk, Chris J. G., van Wyk, Pieter C. V., Venter, Jan A., Verburgt, Luke, Veron, Geraldine, Vetter, Susanne, Vorontsova, Maria S., Wagner, Thomas C., Webala, Paul W., Weber, Natalie, Weier, Sina M., White, Paula A., Whitecross, Melissa A., Wigley, Benjamin J., Willems, Frank J., Winterbach, Christiaan W., and Woodhouse, Galena M.
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- 2024
- Full Text
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8. Canadians’ knowledge of cancer risk factors and belief in cancer myths
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E, Rydz, J, Telfer, EK, Quinn, SS, Fazel, E, Holmes, G, Pennycook, and CE, Peters
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- 2024
- Full Text
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9. ECERS-3: Identifying Gaps and Equity Challenges Focus Group Themes
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University of North Carolina at Chapel Hill, FPG Child Development Institute, Telfer, N. A., Kaplan, R., Yazejian, N., and Iruka, I.
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This report summarizes themes that emerged from six listening sessions held in April 2022 with Black and Latine Pre-K teachers, directors, and technical assistance providers. The purpose of the listening sessions was to understand participants' perceptions of the Early Childhood Environment Rating Scale (ECERS-3) and to gauge the extent to which the tool is culturally grounded.
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- 2022
10. A Year of Wavefront Sensing with JWST in Flight: Cycle 1 Telescope Monitoring and Maintenance Summary
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Lajoie, Charles-Philippe, Lallo, Matthew, Meléndez, Marcio, Flagey, Nicolas, Telfer, Randal, Comeau, Thomas M., Kulp, Bernard A., Beck, Tracy, Brady, Gregory R., and Perrin, Marshall D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We summarize JWST's measured telescope performance across science Cycle 1. The stability of segments alignments is typically better than 10 nanometers RMS between measurements every two days, leading to highly stable point spread functions. The frequency of segment "tilt events" decreased significantly, and larger tilt events ceased entirely, as structures gradually equilibrated after cooldown. Mirror corrections every 1-2 months now maintain the telescope below 70 nm RMS wavefront error. Observed micrometeoroid impacts during cycle 1 had negligible effect on science performance, consistent with preflight predictions. As JWST begins Cycle 2, its optical performance and stability are equal to, and in some ways better than, the performance reported at the end of commissioning., Comment: STScI Technical Memo. 2.5 pages text, 1 figure
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- 2023
11. The James Webb Space Telescope Mission
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Gardner, Jonathan P., Mather, John C., Abbott, Randy, Abell, James S., Abernathy, Mark, Abney, Faith E., Abraham, John G., Abraham, Roberto, Abul-Huda, Yasin M., Acton, Scott, Adams, Cynthia K., Adams, Evan, Adler, David S., Adriaensen, Maarten, Aguilar, Jonathan Albert, Ahmed, Mansoor, Ahmed, Nasif S., Ahmed, Tanjira, Albat, Rüdeger, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Mary Marsha, Allen, Shaune S., Altenburg, Martin, Altunc, Serhat, Alvarez, Jose Lorenzo, Álvarez-Márquez, Javier, de Oliveira, Catarina Alves, Ambrose, Leslie L., Anandakrishnan, Satya M., Andersen, Gregory C., Anderson, Harry James, Anderson, Jay, Anderson, Kristen, Anderson, Sara M., Aprea, Julio, Archer, Benita J., Arenberg, Jonathan W., Argyriou, Ioannis, Arribas, Santiago, Artigau, Étienne, Arvai, Amanda Rose, Atcheson, Paul, Atkinson, Charles B., Averbukh, Jesse, Aymergen, Cagatay, Bacinski, John J., Baggett, Wayne E., Bagnasco, Giorgio, Baker, Lynn L., Balzano, Vicki Ann, Banks, Kimberly A., Baran, David A., Barker, Elizabeth A., Barrett, Larry K., Barringer, Bruce O., Barto, Allison, Bast, William, Baudoz, Pierre, Baum, Stefi, Beatty, Thomas G., Beaulieu, Mathilde, Bechtold, Kathryn, Beck, Tracy, Beddard, Megan M., Beichman, Charles, Bellagama, Larry, Bely, Pierre, Berger, Timothy W., Bergeron, Louis E., Darveau-Bernier, Antoine, Bertch, Maria D., Beskow, Charlotte, Betz, Laura E., Biagetti, Carl P., Birkmann, Stephan, Bjorklund, Kurt F., Blackwood, James D., Blazek, Ronald Paul, Blossfeld, Stephen, Bluth, Marcel, Boccaletti, Anthony, Boegner Jr., Martin E., Bohlin, Ralph C., Boia, John Joseph, Böker, Torsten, Bonaventura, N., Bond, Nicholas A., Bosley, Kari Ann, Boucarut, Rene A., Bouchet, Patrice, Bouwman, Jeroen, Bower, Gary, Bowers, Ariel S., Bowers, Charles W., Boyce, Leslye A., Boyer, Christine T., Boyer, Martha L., Boyer, Michael, Boyer, Robert, Bradley, Larry D., Brady, Gregory R., Brandl, Bernhard R., Brannen, Judith L., Breda, David, Bremmer, Harold G., Brennan, David, Bresnahan, Pamela A., Bright, Stacey N., Broiles, Brian J., Bromenschenkel, Asa, Brooks, Brian H., Brooks, Keira J., Brown, Bob, Brown, Bruce, Brown, Thomas M., Bruce, Barry W., Bryson, Jonathan G., Bujanda, Edwin D., Bullock, Blake M., Bunker, A. J., Bureo, Rafael, Burt, Irving J., Bush, James Aaron, Bushouse, Howard A., Bussman, Marie C., Cabaud, Olivier, Cale, Steven, Calhoon, Charles D., Calvani, Humberto, Canipe, Alicia M., Caputo, Francis M., Cara, Mihai, Carey, Larkin, Case, Michael Eli, Cesari, Thaddeus, Cetorelli, Lee D., Chance, Don R., Chandler, Lynn, Chaney, Dave, Chapman, George N., Charlot, S., Chayer, Pierre, Cheezum, Jeffrey I., Chen, Bin, Chen, Christine H., Cherinka, Brian, Chichester, Sarah C., Chilton, Zachary S., Chittiraibalan, Dharini, Clampin, Mark, Clark, Charles R., Clark, Kerry W., Clark, Stephanie M., Claybrooks, Edward E., Cleveland, Keith A., Cohen, Andrew L., Cohen, Lester M., Colón, Knicole D., Coleman, Benee L., Colina, Luis, Comber, Brian J., Comeau, Thomas M., Comer, Thomas, Reis, Alain Conde, Connolly, Dennis C., Conroy, Kyle E., Contos, Adam R., Contreras, James, Cook, Neil J., Cooper, James L., Cooper, Rachel Aviva, Correia, Michael F., Correnti, Matteo, Cossou, Christophe, Costanza, Brian F., Coulais, Alain, Cox, Colin R., Coyle, Ray T., Cracraft, Misty M., Noriega-Crespo, Alberto, Crew, Keith A., Curtis, Gary J., Cusveller, Bianca, Maciel, Cleyciane Da Costa, Dailey, Christopher T., Daugeron, Frédéric, Davidson, Greg S., Davies, James E., Davis, Katherine Anne, Davis, Michael S., Day, Ratna, de Chambure, Daniel, de Jong, Pauline, De Marchi, Guido, Dean, Bruce H., Decker, John E., Delisa, Amy S., Dell, Lawrence C., Dellagatta, Gail, Dembinska, Franciszka, Demosthenes, Sandor, Dencheva, Nadezhda M., Deneu, Philippe, DePriest, William W., Deschenes, Jeremy, Dethienne, Nathalie, Detre, Örs Hunor, Diaz, Rosa Izela, Dicken, Daniel, DiFelice, Audrey S., Dillman, Matthew, Disharoon, Maureen O., van Dishoeck, Ewine F., Dixon, William V., Doggett, Jesse B., Dominguez, Keisha L., Donaldson, Thomas S., Doria-Warner, Cristina M., Santos, Tony Dos, Doty, Heather, Douglas Jr., Robert E., Doyon, René, Dressler, Alan, Driggers, Jennifer, Driggers, Phillip A., Dunn, Jamie L., DuPrie, Kimberly C., Dupuis, Jean, Durning, John, Dutta, Sanghamitra B., Earl, Nicholas M., Eccleston, Paul, Ecobichon, Pascal, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan D., Eisenhower, Michael, Eisenstein, Daniel J., Hamel, Zaky El, Elie, Michelle L., Elliott, James, Elliott, Kyle Wesley, Engesser, Michael, Espinoza, Néstor, Etienne, Odessa, Etxaluze, Mireya, Evans, Leah, Fabreguettes, Luce, Falcolini, Massimo, Falini, Patrick R., Fatig, Curtis, Feeney, Matthew, Feinberg, Lee D., Fels, Raymond, Ferdous, Nazma, Ferguson, Henry C., Ferrarese, Laura, Ferreira, Marie-Héléne, Ferruit, Pierre, Ferry, Malcolm, Filippazzo, Joseph Charles, Firre, Daniel, Fix, Mees, Flagey, Nicolas, Flanagan, Kathryn A., Fleming, Scott W., Florian, Michael, Flynn, James R., Foiadelli, Luca, Fontaine, Mark R., Fontanella, Erin Marie, Forshay, Peter Randolph, Fortner, Elizabeth A., Fox, Ori D., Framarini, Alexandro P., Francisco, John I., Franck, Randy, Franx, Marijn, Franz, David E., Friedman, Scott D., Friend, Katheryn E., Frost, James R., Fu, Henry, Fullerton, Alexander W., Gaillard, Lionel, Galkin, Sergey, Gallagher, Ben, Galyer, Anthony D., Marín, Macarena García, Gardner, Lisa E., Garland, Dennis, Garrett, Bruce Albert, Gasman, Danny, Gáspár, András, Gastaud, René, Gaudreau, Daniel, Gauthier, Peter Timothy, Geers, Vincent, Geithner, Paul H., Gennaro, Mario, Gerber, John, Gereau, John C., Giampaoli, Robert, Giardino, Giovanna, Gibbons, Paul C., Gilbert, Karolina, Gilman, Larry, Girard, Julien H., Giuliano, Mark E., Gkountis, Konstantinos, Glasse, Alistair, Glassmire, Kirk Zachary, Glauser, Adrian Michael, Glazer, Stuart D., Goldberg, Joshua, Golimowski, David A., Gonzaga, Shireen P., Gordon, Karl D., Gordon, Shawn J., Goudfrooij, Paul, Gough, Michael J., Graham, Adrian J., Grau, Christopher M., Green, Joel David, Greene, Gretchen R., Greene, Thomas P., Greenfield, Perry E., Greenhouse, Matthew A., Greve, Thomas R., Greville, Edgar M., Grimaldi, Stefano, Groe, Frank E., Groebner, Andrew, Grumm, David M., Grundy, Timothy, Güdel, Manuel, Guillard, Pierre, Guldalian, John, Gunn, Christopher A., Gurule, Anthony, Gutman, Irvin Meyer, Guy, Paul D., Guyot, Benjamin, Hack, Warren J., Haderlein, Peter, Hagan, James B., Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest Clifford, Hammann, Jeffrey, Hammel, Heidi B., Hanley, Christopher J., Hansen, Carl August, Hardy, Bruce, Harnisch, Bernd, Harr, Michael Hunter, Harris, Pamela, Hart, Jessica Ann, Hartig, George F., Hasan, Hashima, Hashim, Kathleen Marie, Hashimoto, Ryan, Haskins, Sujee J., Hawkins, Robert Edward, Hayden, Brian, Hayden, William L., Healy, Mike, Hecht, Karen, Heeg, Vince J., Hejal, Reem, Helm, Kristopher A., Hengemihle, Nicholas J., Henning, Thomas, Henry, Alaina, Henry, Ronald L., Henshaw, Katherine, Hernandez, Scarlin, Herrington, Donald C., Heske, Astrid, Hesman, Brigette Emily, Hickey, David L., Hilbert, Bryan N., Hines, Dean C., Hinz, Michael R., Hirsch, Michael, Hitcho, Robert S., Hodapp, Klaus, Hodge, Philip E., Hoffman, Melissa, Holfeltz, Sherie T., Holler, Bryan Jason, Hoppa, Jennifer Rose, Horner, Scott, Howard, Joseph M., Howard, Richard J., Huber, Jean M., Hunkeler, Joseph S., Hunter, Alexander, Hunter, David Gavin, Hurd, Spencer W., Hurst, Brendan J., Hutchings, John B., Hylan, Jason E., Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra M., Isaacs III, John C., Jackson Jr., Wallace C., Jaffe, Daniel T., Jahic, Jasmin, Jahromi, Amir, Jakobsen, Peter, James, Bryan, James, John C., James, LeAndrea Rae, Jamieson, William Brian, Jandra, Raymond D., Jayawardhana, Ray, Jedrzejewski, Robert, Jeffers, Basil S., Jensen, Peter, Joanne, Egges, Johns, Alan T., Johnson, Carl A., Johnson, Eric L., Johnson, Patricia, Johnson, Phillip Stephen, Johnson, Thomas K., Johnson, Timothy W., Johnstone, Doug, Jollet, Delphine, Jones, Danny P., Jones, Gregory S., Jones, Olivia C., Jones, Ronald A., Jones, Vicki, Jordan, Ian J., Jordan, Margaret E., Jue, Reginald, Jurkowski, Mark H., Justis, Grant, Justtanont, Kay, Kaleida, Catherine C., Kalirai, Jason S., Kalmanson, Phillip Cabrales, Kaltenegger, Lisa, Kammerer, Jens, Kan, Samuel K., Kanarek, Graham Childs, Kao, Shaw-Hong, Karakla, Diane M., Karl, Hermann, Kassin, Susan A., Kauffman, David D., Kavanagh, Patrick, Kelley, Leigh L., Kelly, Douglas M., Kendrew, Sarah, Kennedy, Herbert V., Kenny, Deborah A., Keski-Kuha, Ritva A., Keyes, Charles D., Khan, Ali, Kidwell, Richard C., Kimble, Randy A., King, James S., King, Richard C., Kinzel, Wayne M., Kirk, Jeffrey R., Kirkpatrick, Marc E., Klaassen, Pamela, Klingemann, Lana, Klintworth, Paul U., Knapp, Bryan Adam, Knight, Scott, Knollenberg, Perry J., Knutsen, Daniel Mark, Koehler, Robert, Koekemoer, Anton M., Kofler, Earl T., Kontson, Vicki L., Kovacs, Aiden Rose, Kozhurina-Platais, Vera, Krause, Oliver, Kriss, Gerard A., Krist, John, Kristoffersen, Monica R., Krogel, Claudia, Krueger, Anthony P., Kulp, Bernard A., Kumari, Nimisha, Kwan, Sandy W., Kyprianou, Mark, Labador, Aurora Gadiano, Labiano, Álvaro, Lafrenière, David, Lagage, Pierre-Olivier, Laidler, Victoria G., Laine, Benoit, Laird, Simon, Lajoie, Charles-Philippe, Lallo, Matthew D., Lam, May Yen, LaMassa, Stephanie Marie, Lambros, Scott D., Lampenfield, Richard Joseph, Lander, Matthew Ed, Langston, James Hutton, Larson, Kirsten, Larson, Melora, LaVerghetta, Robert Joseph, Law, David R., Lawrence, Jon F., Lee, David W., Lee, Janice, Lee, Yat-Ning Paul, Leisenring, Jarron, Leveille, Michael Dunlap, Levenson, Nancy A., Levi, Joshua S., Levine, Marie B., Lewis, Dan, Lewis, Jake, Lewis, Nikole, Libralato, Mattia, Lidon, Norbert, Liebrecht, Paula Louisa, Lightsey, Paul, Lilly, Simon, Lim, Frederick C., Lim, Pey Lian, Ling, Sai-Kwong, Link, Lisa J., Link, Miranda Nicole, Lipinski, Jamie L., Liu, XiaoLi, Lo, Amy S., Lobmeyer, Lynette, Logue, Ryan M., Long, Chris A., Long, Douglas R., Long, Ilana D., Long, Knox S., López-Caniego, Marcos, Lotz, Jennifer M., Love-Pruitt, Jennifer M., Lubskiy, Michael, Luers, Edward B., Luetgens, Robert A., Luevano, Annetta J., Lui, Sarah Marie G. Flores, Lund III, James M., Lundquist, Ray A., Lunine, Jonathan, Lützgendorf, Nora, Lynch, Richard J., MacDonald, Alex J., MacDonald, Kenneth, Macias, Matthew J., Macklis, Keith I., Maghami, Peiman, Maharaja, Rishabh Y., Maiolino, Roberto, Makrygiannis, Konstantinos G., Malla, Sunita Giri, Malumuth, Eliot M., Manjavacas, Elena, Marini, Andrea, Marrione, Amanda, Marston, Anthony, Martel, André R, Martin, Didier, Martin, Peter G., Martinez, Kristin L., Maschmann, Marc, Masci, Gregory L., Masetti, Margaret E., Maszkiewicz, Michael, Matthews, Gary, Matuskey, Jacob E., McBrayer, Glen A., McCarthy, Donald W., McCaughrean, Mark J., McClare, Leslie A., McClare, Michael D., McCloskey, John C., McClurg, Taylore D., McCoy, Martin, McElwain, Michael W., McGregor, Roy D., McGuffey, Douglas B., McKay, Andrew G., McKenzie, William K., McLean, Brian, McMaster, Matthew, McNeil, Warren, De Meester, Wim, Mehalick, Kimberly L., Meixner, Margaret, Meléndez, Marcio, Menzel, Michael P., Menzel, Michael T., Merz, Matthew, Mesterharm, David D., Meyer, Michael R., Meyett, Michele L., Meza, Luis E., Midwinter, Calvin, Milam, Stefanie N., Miller, Jay Todd, Miller, William C., Miskey, Cherie L., Misselt, Karl, Mitchell, Eileen P., Mohan, Martin, Montoya, Emily E., Moran, Michael J., Morishita, Takahiro, Moro-Martín, Amaya, Morrison, Debra L., Morrison, Jane, Morse, Ernie C., Moschos, Michael, Moseley, S. H., Mosier, Gary E., Mosner, Peter, Mountain, Matt, Muckenthaler, Jason S., Mueller, Donald G., Mueller, Migo, Muhiem, Daniella, Mühlmann, Prisca, Mullally, Susan Elizabeth, Mullen, Stephanie M., Munger, Alan J, Murphy, Jess, Murray, Katherine T., Muzerolle, James C., Mycroft, Matthew, Myers, Andrew, Myers, Carey R., Myers, Fred Richard R., Myers, Richard, Myrick, Kaila, Nagle IV, Adrian F., Nayak, Omnarayani, Naylor, Bret, Neff, Susan G., Nelan, Edmund P., Nella, John, Nguyen, Duy Tuong, Nguyen, Michael N., Nickson, Bryony, Nidhiry, John Joseph, Niedner, Malcolm B., Nieto-Santisteban, Maria, Nikolov, Nikolay K., Nishisaka, Mary Ann, Nota, Antonella, O'Mara, Robyn C., Oboryshko, Michael, O'Brien, Marcus B., Ochs, William R., Offenberg, Joel D., Ogle, Patrick Michael, Ohl, Raymond G., Olmsted, Joseph Hamden, Osborne, Shannon Barbara, O'Shaughnessy, Brian Patrick, Östlin, Göran, O'Sullivan, Brian, Otor, O. Justin, Ottens, Richard, Ouellette, Nathalie N. -Q., Outlaw, Daria J., Owens, Beverly A., Pacifici, Camilla, Page, James Christophe, Paranilam, James G., Park, Sang, Parrish, Keith A., Paschal, Laura, Patapis, Polychronis, Patel, Jignasha, Patrick, Keith, Pattishall Jr., Robert A., Paul, Douglas William, Paul, Shirley J., Pauly, Tyler Andrew, Pavlovsky, Cheryl M., Peña-Guerrero, Maria, Pedder, Andrew H., Peek, Matthew Weldon, Pelham, Patricia A., Penanen, Konstantin, Perriello, Beth A., Perrin, Marshall D., Perrine, Richard F., Perrygo, Chuck, Peslier, Muriel, Petach, Michael, Peterson, Karla A., Pfarr, Tom, Pierson, James M., Pietraszkiewicz, Martin, Pilchen, Guy, Pipher, Judy L., Pirzkal, Norbert, Pitman, Joseph T., Player, Danielle M., Plesha, Rachel, Plitzke, Anja, Pohner, John A., Poletis, Karyn Konstantin, Pollizzi, Joseph A., Polster, Ethan, Pontius, James T., Pontoppidan, Klaus, Porges, Susana C., Potter, Gregg D., Prescott, Stephen, Proffitt, Charles R., Pueyo, Laurent, Neira, Irma Aracely Quispe, Radich, Armando, Rager, Reiko T., Rameau, Julien, Ramey, Deborah D., Alarcon, Rafael Ramos, Rampini, Riccardo, Rapp, Robert, Rashford, Robert A., Rauscher, Bernard J., Ravindranath, Swara, Rawle, Timothy, Rawlings, Tynika N., Ray, Tom, Regan, Michael W., Rehm, Brian, Rehm, Kenneth D., Reid, Neill, Reis, Carl A., Renk, Florian, Reoch, Tom B., Ressler, Michael, Rest, Armin W., Reynolds, Paul J., Richon, Joel G., Richon, Karen V., Ridgaway, Michael, Riedel, Adric Richard, Rieke, George H., Rieke, Marcia, Rifelli, Richard E., Rigby, Jane R., Riggs, Catherine S., Ringel, Nancy J., Ritchie, Christine E., Rix, Hans-Walter, Robberto, Massimo, Robinson, Michael S., Robinson, Orion, Rock, Frank W., Rodriguez, David R., del Pino, Bruno Rodríguez, Roellig, Thomas, Rohrbach, Scott O., Roman, Anthony J., Romelfanger, Frederick J., Romo Jr., Felipe P., Rosales, Jose J., Rose, Perry, Roteliuk, Anthony F., Roth, Marc N., Rothwell, Braden Quinn, Rouzaud, Sylvain, Rowe, Jason, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Rui, Chunlei, Rumler, Peter, Rumpl, William, Russ, Melissa L., Ryan, Michael B., Ryan, Richard M., Saad, Karl, Sabata, Modhumita, Sabatino, Rick, Sabbi, Elena, Sabelhaus, Phillip A., Sabia, Stephen, Sahu, Kailash C., Saif, Babak N., Salvignol, Jean-Christophe, Samara-Ratna, Piyal, Samuelson, Bridget S., Sanders, Felicia A., Sappington, Bradley, Sargent, B. A., Sauer, Arne, Savadkin, Bruce J., Sawicki, Marcin, Schappell, Tina M., Scheffer, Caroline, Scheithauer, Silvia, Scherer, Ron, Schiff, Conrad, Schlawin, Everett, Schmeitzky, Olivier, Schmitz, Tyler S., Schmude, Donald J., Schneider, Analyn, Schreiber, Jürgen, Schroeven-Deceuninck, Hilde, Schultz, John J., Schwab, Ryan, Schwartz, Curtis H., Scoccimarro, Dario, Scott, John F., Scott, Michelle B., Seaton, Bonita L., Seely, Bruce S., Seery, Bernard, Seidleck, Mark, Sembach, Kenneth, Shanahan, Clare Elizabeth, Shaughnessy, Bryan, Shaw, Richard A., Shay, Christopher Michael, Sheehan, Even, Sheth, Kartik, Shih, Hsin-Yi, Shivaei, Irene, Siegel, Noah, Sienkiewicz, Matthew G., Simmons, Debra D., Simon, Bernard P., Sirianni, Marco, Sivaramakrishnan, Anand, Slade, Jeffrey E., Sloan, G. C., Slocum, Christine E., Slowinski, Steven E., Smith, Corbett T., Smith, Eric P., Smith, Erin C., Smith, Koby, Smith, Robert, Smith, Stephanie J., Smolik, John L., Soderblom, David R., Sohn, Sangmo Tony, Sokol, Jeff, Sonneborn, George, Sontag, Christopher D., Sooy, Peter R., Soummer, Remi, Southwood, Dana M., Spain, Kay, Sparmo, Joseph, Speer, David T., Spencer, Richard, Sprofera, Joseph D., Stallcup, Scott S., Stanley, Marcia K., Stansberry, John A., Stark, Christopher C., Starr, Carl W., Stassi, Diane Y., Steck, Jane A., Steeley, Christine D., Stephens, Matthew A., Stephenson, Ralph J., Stewart, Alphonso C., Stiavelli, Massimo, Stockman Jr., Hervey, Strada, Paolo, Straughn, Amber N., Streetman, Scott, Strickland, David Kendal, Strobele, Jingping F., Stuhlinger, Martin, Stys, Jeffrey Edward, Such, Miguel, Sukhatme, Kalyani, Sullivan, Joseph F., Sullivan, Pamela C., Sumner, Sandra M., Sun, Fengwu, Sunnquist, Benjamin Dale, Swade, Daryl Allen, Swam, Michael S., Swenton, Diane F., Swoish, Robby A., Litten, Oi In Tam, Tamas, Laszlo, Tao, Andrew, Taylor, David K., Taylor, Joanna M., Plate, Maurice te, Van Tea, Mason, Teague, Kelly K., Telfer, Randal C., Temim, Tea, Texter, Scott C., Thatte, Deepashri G., Thompson, Christopher Lee, Thompson, Linda M., Thomson, Shaun R., Thronson, Harley, Tierney, C. M., Tikkanen, Tuomo, Tinnin, Lee, Tippet, William Thomas, Todd, Connor William, Tran, Hien D., Trauger, John, Trejo, Edwin Gregorio, Truong, Justin Hoang Vinh, Tsukamoto, Christine L., Tufail, Yasir, Tumlinson, Jason, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael A., Vaclavik, Steven, Valenduc, Frida, Valenti, Jeff A., Van Campen, Julie, van de Wetering, Inge, Van Der Marel, Roeland P., van Haarlem, Remy, Vandenbussche, Bart, Vanterpool, Dona D., Vernoy, Michael R., Costas, Maria Begoña Vila, Volk, Kevin, Voorzaat, Piet, Voyton, Mark F., Vydra, Ekaterina, Waddy, Darryl J., Waelkens, Christoffel, Wahlgren, Glenn Michael, Walker Jr., Frederick E., Wander, Michel, Warfield, Christine K., Warner, Gerald, Wasiak, Francis C., Wasiak, Matthew F., Wehner, James, Weiler, Kevin R., Weilert, Mark, Weiss, Stanley B., Wells, Martyn, Welty, Alan D., Wheate, Lauren, Wheeler, Thomas P., White, Christy L., Whitehouse, Paul, Whiteleather, Jennifer Margaret, Whitman, William Russell, Williams, Christina C., Willmer, Christopher N. A., Willott, Chris J., Willoughby, Scott P., Wilson, Andrew, Wilson, Debra, Wilson, Donna V., Windhorst, Rogier, Wislowski, Emily Christine, Wolfe, David J., Wolfe, Michael A., Wolff, Schuyler, Wondel, Amancio, Woo, Cindy, Woods, Robert T., Worden, Elaine, Workman, William, Wright, Gillian S., Wu, Carl, Wu, Chi-Rai, Wun, Dakin D., Wymer, Kristen B., Yadetie, Thomas, Yan, Isabelle C., Yang, Keith C., Yates, Kayla L., Yeager, Christopher R., Yerger, Ethan John, Young, Erick T., Young, Gary, Yu, Gene, Yu, Susan, Zak, Dean S., Zeidler, Peter, Zepp, Robert, Zhou, Julia, Zincke, Christian A., Zonak, Stephanie, and Zondag, Elisabeth
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit., Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figures
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- 2023
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12. The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance
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McElwain, Michael W., Feinberg, Lee D., Perrin, Marshall D., Clampin, Mark, Mountain, C. Matt, Lallo, Matthew D., Lajoie, Charles-Philippe, Kimble, Randy A., Bowers, Charles W., Stark, Christopher C., Acton, D. Scott, Aiello, Ken, Atkinson, Charles, Barinek, Beth, Barto, Allison, Basinger, Scott, Beck, Tracy, Bergkoetter, Matthew D., Bluth, Marcel, Boucarut, Rene A., Brady, Gregory R., Brooks, Keira J., Brown, Bob, Byard, John, Carey, Larkin, Carrasquilla, Maria, Celeste, Sid, Chae, Dan, Chaney, David, Chayer, Pierre, Chonis, Taylor, Cohen, Lester, Cole, Helen J., Comeau, Thomas M., Coon, Matthew, Coppock, Eric, Coyle, Laura, Davis, Rick, Dean, Bruce H., Dziak, Kenneth J., Eisenhower, Michael, Flagey, Nicolas, Franck, Randy, Gallagher, Benjamin, Gilman, Larry, Glassman, Tiffany, Golnik, Gary, Green, Joseph J., Grieco, John, Haase, Shari, Hadjimichael, Theodore J., Hagopian, John G., Hahn, Walter G., Hartig, George F., Havey, Keith A., Hayden, William L., Hellekson, Robert, Hicks, Brian, Holfeltz, Sherie T., Howard, Joseph M., Huguet, Jesse A., Jahne, Brian, Johnson, Leslie A., Johnston, John D., Jurling, Alden S., Kegley, Jeffrey R., Kennard, Scott, Keski-Kuha, Ritva A., Knight, J. Scott, Kulp, Bernard A., Levi, Joshua S., Levine, Marie B., Lightsey, Paul, Luetgens, Robert A., Mather, John C., Matthews, Gary W., McKay, Andrew G., Mehalick, Kimberly I., Meléndez, Marcio, Messer, Ted, Mosier, Gary E., Murphy, Jess, Nelan, Edmund P., Niedner, Malcolm B., Noël, Darin M., Ohara, Catherine M., Ohl, Raymond G., Olczak, Eugene, Osborne, Shannon B., Park, Sang, Patton, Kevin, Perrygo, Charles, Pueyo, Laurent, Quesnel, Lisbeth, Ranck, Dale, Redding, David C., Regan, Michael W., Reynolds, Paul, Rifelli, Rich, Rigby, Jane R., Sabatke, Derek, Saif, Babak N., Scorse, Thomas R., Seo, Byoung-Joon, Shi, Fang, Sigrist, Norbert, Smith, Koby, Smith, J. Scott, Smith, Erin C., Sohn, Sangmo Tony, Spina, John, Stahl, H. Philip, Telfer, Randal, Terlecki, Todd, Texter, Scott C., Van Buren, David, Van Campen, Julie M., Vila, Begoña, Voyton, Mark F., Waldman, Mark, Walker, Chanda B., Weiser, Nick, Wells, Conrad, West, Garrett, Whitman, Tony L., Wick, Eric, Wolf, Erin, Young, Greg, and Zielinski, Thomas P.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The James Webb Space Telescope (JWST) is a large, infrared space telescope that has recently started its science program which will enable breakthroughs in astrophysics and planetary science. Notably, JWST will provide the very first observations of the earliest luminous objects in the Universe and start a new era of exoplanet atmospheric characterization. This transformative science is enabled by a 6.6 m telescope that is passively cooled with a 5-layer sunshield. The primary mirror is comprised of 18 controllable, low areal density hexagonal segments, that were aligned and phased relative to each other in orbit using innovative image-based wavefront sensing and control algorithms. This revolutionary telescope took more than two decades to develop with a widely distributed team across engineering disciplines. We present an overview of the telescope requirements, architecture, development, superb on-orbit performance, and lessons learned. JWST successfully demonstrates a segmented aperture space telescope and establishes a path to building even larger space telescopes., Comment: accepted by PASP for JWST Overview Special Issue; 34 pages, 25 figures
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- 2023
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13. A type 1 hybrid multi-site randomized controlled trial protocol for evaluating virtual interview training among autistic transition-age youth
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Matthew J. Smith, James L. Merle, Mary Baker-Ericzén, Kari Sherwood, Lindsay A. Bornheimer, Brittany Ross, Meghan Harrington, Apara Sharma, Cheryl Brown, Timotheus (TJ) Gordon, ., David Telfer, Jocelyn Reese, Jennifer Hirst, Eugene A. Oulvey, Valerie Dignadice, Ed-Dee Williams, Sandra Magaña, Kara Hume, Connie Sung, Jane K. Burke-Miller, and Justin D. Smith
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autism ,transition-age youth ,employment ,job interview skills ,virtual interview training ,Medicine (General) ,R5-920 - Abstract
A number of policies mandate that autistic transition-age youth receive employment services to prepare for the workforce before high school graduation. A key limitation to these services is the job interview component, which relies on non-standardized, resource-intensive, staff-led role-plays to help autistic transition-age youth improve their interview skills. The autism community has called for better job interview preparation. To address this gap in services, our team, collaborated with the autism community to adapt the intervention, Virtual Reality Job Interview Training (VR-JIT; effective among adults with serious mental illness), into Virtual Interview Training for Transition Age Youth (VIT-TAY). This adapted intervention was tailored to meet the needs of autistic transition age youth while maintaining the core components of VR-JIT (i.e., an online job interview simulator with four levels of automated feedback and e-learning content). A pilot randomized controlled trial (RCT) demonstrated VIT-TAY's feasibility and initial effectiveness at improving job interview skills, reducing anxiety, and increasing employment rates within six months when added to transition services or pre-employment transition services (Pre-ETS). Thus, the overarching goal of this Hybrid Type 1 effectiveness-implementation study protocol is to conduct a fully-powered RCT of VIT-TAY across 16 schools in various geographical locations. Our specific aims are to 1) Evaluate whether Pre-ETS (or transition services) with VIT-TAY, as compared to Pre-ETS (or transition services) with an active control intervention (i.e., job interview didactics/e-learning with a series of 3–5 min videos of employed autistic adults talking about their career pathways) enhances employment outcomes; 2) Evaluate mechanisms of employment by nine months post-randomization; and 3) Conduct a multilevel, mixed-method process evaluation of the initial implementation of VIT-TAY across settings (e.g., acceptability, feasibility, and barriers and facilitators of implementation).
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- 2024
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14. Feedback and focus: Exploring post-secondary students’ perceptions of feedback, mindfulness, and stress
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Cecilia S. Dong, Erin Isings, Samantha M. Jones, Hugh Samson, Lisa McCorquodale, Thomas G. W. Telfer, Tracey Ropp, and Christine E. Bell
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Feedback ,mindfulness ,stress ,learning ,post-secondary students ,Stephen Darwin, Universidad Alberto Hurtado, Chile ,Education (General) ,L7-991 - Abstract
AbstractAddressing feedback-associated stress as a barrier to learning is increasingly relevant to student success and well-being. Mindfulness practices support stress management for students during the academic feedback process. Even if students receive high-quality feedback, the receiving end of feedback can be stressful, perhaps raising feelings of anxiety, confusion, or inadequacy. Feedback literacy and mindfulness practices complement one another. Mindfulness can potentially support feedback literacy by focusing one’s attention on the tasks needed to address feedback, instead of being distracted by emotions triggered by feedback. This study, comprised of an online survey (n = 237) and focus groups (n = 6), assesses post-secondary students’ perceptions concerning feedback literacy, mindfulness, and stress, and their thoughts about digital mindfulness tools intended to support students experiencing feedback-associated stress. Recruitment of students was from courses in Health Sciences, Medical Sciences, Media Studies, and Law. The survey data demonstrate that students with greater mindfulness have significantly greater feedback literacy as well as lower stress. Focus group data shows that a broad range of affective and behavioral responses are shaped by students’ perceptions of their abilities, circumstances, and feedback itself. Although students expressed familiarity with mindfulness practices, few considered explicitly linking mindfulness to their feedback process. Nevertheless, students expressed interest regarding the development of digital mindfulness tools to alleviate feedback-associated stress and offered recommendations for implementation.
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- 2024
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15. The genome sequence of the oak pinhole borer, Platypus cylindrus (Fabricius, 1792) [version 2; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Maxwell V. L. Barclay, Keita Matsumoto, Danaë Vassiliades, Joana Cristóvão, Michael Geiser, and Will Bayfield Farrell
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Platypus cylindrus ,oak pinhole borer ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Platypus cylindrus (the oak pinhole borer; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 147.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,468 protein coding genes.
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- 2024
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16. The genome sequence of a metallic wood-boring beetle, Agrilus cyanescens (Ratzeburg, 1837) [version 2; peer review: 2 approved, 1 not approved]
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Mark G. Telfer and Dominic Phillips
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Agrilus cyanescens ,metallic wood-boring beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Agrilus cyanescens (metallic wood-boring beetle; Arthropoda; Insecta; Coleoptera; Buprestidae). The genome sequence is 292.3 megabases in span. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.91 kilobases in length.
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- 2024
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17. Building Digital Twins for Cardiovascular Health: From Principles to Clinical Impact
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Kaan Sel, Deen Osman, Fatemeh Zare, Sina Masoumi Shahrbabak, Laura Brattain, Jin‐Oh Hahn, Omer T. Inan, Ramakrishna Mukkamala, Jeffrey Palmer, David Paydarfar, Roderic I. Pettigrew, Arshed A. Quyyumi, Brian Telfer, and Roozbeh Jafari
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cardiovascular modeling ,computational physiology ,digital representation ,precision health ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The past several decades have seen rapid advances in diagnosis and treatment of cardiovascular diseases and stroke, enabled by technological breakthroughs in imaging, genomics, and physiological monitoring, coupled with therapeutic interventions. We now face the challenge of how to (1) rapidly process large, complex multimodal and multiscale medical measurements; (2) map all available data streams to the trajectories of disease states over the patient's lifetime; and (3) apply this information for optimal clinical interventions and outcomes. Here we review new advances that may address these challenges using digital twin technology to fulfill the promise of personalized cardiovascular medical practice. Rooted in engineering mechanics and manufacturing, the digital twin is a virtual representation engineered to model and simulate its physical counterpart. Recent breakthroughs in scientific computation, artificial intelligence, and sensor technology have enabled rapid bidirectional interactions between the virtual‐physical counterparts with measurements of the physical twin that inform and improve its virtual twin, which in turn provide updated virtual projections of disease trajectories and anticipated clinical outcomes. Verification, validation, and uncertainty quantification builds confidence and trust by clinicians and patients in the digital twin and establishes boundaries for the use of simulations in cardiovascular medicine. Mechanistic physiological models form the fundamental building blocks of the personalized digital twin that continuously forecast optimal management of cardiovascular health using individualized data streams. We present exemplars from the existing body of literature pertaining to mechanistic model development for cardiovascular dynamics and summarize existing technical challenges and opportunities pertaining to the foundation of a digital twin.
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- 2024
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18. Response to ′Is the Displacement of People from Parks only ′Purported′ or is it Real?′ (Schmidt-Soltau 2009)
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Curran Bryan, Sunderland Terry, Maisels Fiona, Asaha Stella, Balinga Michael, Defo Louis, Dunn Andrew, Loebenstein Karin, Oates John, Roth Philipp, Telfer Paul, and Usongo Leonard
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Ecology ,QH540-549.5 - Published
- 2010
19. Are Central Africa′s Protected Areas Displacing Hundreds of Thousands of Rural Poor?
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Curran Bryan, Sunderland Terry, Maisels Fiona, Oates John, Asaha Stella, Balinga Michael, Defo Louis, Dunn Andrew, Telfer Paul, Usongo Leonard, Loebenstein Karin, and Roth Philipp
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biodiversity conservation ,Central Africa ,displacement ,protected areas ,Ecology ,QH540-549.5 - Abstract
An ongoing debate over the impacts of protected areas on rural communities in central Africa has become increasingly polarized in recent years, even as definitions of displacement have shifted from outright expulsion to economic dislocation precipitated by lost access to natural resources. Although forcible removal of communities to make way for the creation of National Parks has certainly occurred in the past in some parts of the world, we contend that not a single individual has been physically removed from any of the protected areas created in central Africa over the past decade, despite claims to the contrary of hundreds of thousands of "conservation refugees." Furthermore, we recognize that a scarcity of data precludes impartial evaluation of the potential impacts of economic displacement of local communities living adjacent to protected areas, and we call for a concerted effort by conservationists and the social scientists who criticize conservation efforts, in order to measure the effects of protected areas on livelihoods, and to work towards a more socially responsible conservation paradigm.
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- 2009
20. ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES): protocol for a randomised controlled trial of remotely delivered fitness training for brain health
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Amy Brodtmann, Alex Billett, Rachael Telfer, Kim Adkins, Laura White, Laura J. E. McCambridge, Louise M. Burrell, Vincent Thijs, Sharon Kramer, Emilio Werden, Barbara R. Cardoso, Matthew Pase, Stanley Hughwa Hung, Leonid Churilov, Julie Bernhardt, Kathryn Hayward, and Liam Johnson
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Ischaemic stroke ,Dementia ,Cognition ,Exercise training ,Physical activity ,Telerehabilitation ,Medicine (General) ,R5-920 - Abstract
Abstract Background Stroke increases subsequent dementia risk yet there are no specific post-stroke therapies to protect cognition. Cardiorespiratory exercise is recommended for secondary prevention of stroke and may be neuroprotective. The Post Ischaemic Stroke Cardiovascular Exercise Study (PISCES) aims to reduce post-stroke secondary neurodegeneration and cognitive decline. During the pandemic, we pivoted to a ZOom Delivered Intervention Against Cognitive decline (ZODIAC) protocol, reducing pandemic-amplified barriers to exercise. Methods We present pandemic adaptions for a multicentre phase IIb assessor-blinded randomised controlled trial of ischaemic stroke survivors testing the efficacy and feasibility of an 8-week home-based exercise intervention delivered at 2 months post-stroke. We compare cardiorespiratory exercise (intervention arm) versus balance and stretching (active control arm). Participants are assessed with magnetic resonance imaging (MRI), fitness, blood, microbiome, and neuropsychological tests at three study visits: before and after the exercise intervention and at 12 months. Modifications to the original protocol include pre-exercise safety home visits, commercial delivery of exercise equipment to facilitate assessor blinding, and reconsideration of statistical plan to allow pooling of the studies. We have reduced in-person study visits from 27 to 3. Primary outcome remains between-group (intervention versus control) difference in brain volume change; secondary outcome is between-group difference in global cognitive ability to allow remote administration of a validated cognitive scale. Discussion Remotely delivered exercise interventions reduce participant burden and may reduce barriers to recruitment. A decrease in the number of in-person study visits can be supported by greater information capture via self-reported questionnaires and phone surveys. Trial registration Prospectively ACTRN12616000942459. Registered on July 2016.
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- 2024
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21. Global arthropod beta-diversity is spatially and temporally structured by latitude
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Mathew Seymour, Tomas Roslin, Jeremy R. deWaard, Kate H. J. Perez, Michelle L. D’Souza, Sujeevan Ratnasingham, Muhammad Ashfaq, Valerie Levesque-Beaudin, Gergin A. Blagoev, Belén Bukowski, Peter Cale, Denise Crosbie, Thibaud Decaëns, Stephanie L. deWaard, Torbjørn Ekrem, Hosam O. El-Ansary, Fidèle Evouna Ondo, David Fraser, Matthias F. Geiger, Mehrdad Hajibabaei, Winnie Hallwachs, Priscila E. Hanisch, Axel Hausmann, Mark Heath, Ian D. Hogg, Daniel H. Janzen, Margaret Kinnaird, Joshua R. Kohn, Maxim Larrivée, David C. Lees, Virginia León-Règagnon, Michael Liddell, Darío A. Lijtmaer, Tatsiana Lipinskaya, Sean A. Locke, Ramya Manjunath, Dino J. Martins, Marlúcia B. Martins, Santosh Mazumdar, Jaclyn T. A. McKeown, Kristina Anderson-Teixeria, Scott E. Miller, Megan A. Milton, Renee Miskie, Jérôme Morinière, Marko Mutanen, Suresh Naik, Becky Nichols, Felipe A. Noguera, Vojtech Novotny, Lyubomir Penev, Mikko Pentinsaari, Jenna Quinn, Leah Ramsay, Regina Rochefort, Stefan Schmidt, M. Alex Smith, Crystal N. Sobel, Panu Somervuo, Jayme E. Sones, Hermann S. Staude, Brianne St. Jaques, Elisabeth Stur, Angela C. Telfer, Pablo L. Tubaro, Tim J. Wardlaw, Robyn Worcester, Zhaofu Yang, Monica R. Young, Tyler Zemlak, Evgeny V. Zakharov, Bradley Zlotnick, Otso Ovaskainen, and Paul D. N. Hebert
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Biology (General) ,QH301-705.5 - Abstract
Abstract Global biodiversity gradients are generally expected to reflect greater species replacement closer to the equator. However, empirical validation of global biodiversity gradients largely relies on vertebrates, plants, and other less diverse taxa. Here we assess the temporal and spatial dynamics of global arthropod biodiversity dynamics using a beta-diversity framework. Sampling includes 129 sampling sites whereby malaise traps are deployed to monitor temporal changes in arthropod communities. Overall, we encountered more than 150,000 unique barcode index numbers (BINs) (i.e. species proxies). We assess between site differences in community diversity using beta-diversity and the partitioned components of species replacement and richness difference. Global total beta-diversity (dissimilarity) increases with decreasing latitude, greater spatial distance and greater temporal distance. Species replacement and richness difference patterns vary across biogeographic regions. Our findings support long-standing, general expectations of global biodiversity patterns. However, we also show that the underlying processes driving patterns may be regionally linked.
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- 2024
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22. Cancer diagnosis after emergency presentations in people with mental health and substance use conditions: a national cohort study
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Ruth Cunningham, James Stanley, Fiona Imlach, Tracy Haitana, Helen Lockett, Susanna Every-Palmer, Mau Te Rangimarie Clark, Cameron Lacey, Kendra Telfer, and Debbie Peterson
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Cancer ,Mental health and substance use disorders ,Emergency presentation ,Health disparities ,Lung neoplasms ,Colorectal neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Cancer survival and mortality outcomes for people with mental health and substance use conditions (MHSUC) are worse than for people without MHSUC, which may be partly explained by poorer access to timely and appropriate healthcare, from screening and diagnosis through to treatment and follow-up. Access and quality of healthcare can be evaluated by comparing the proportion of people who receive a cancer diagnosis following an acute or emergency hospital admission (emergency presentation) across different population groups: those diagnosed with cancer following an emergency presentation have lower survival. Methods National mental health service use datasets (2002–2018) were linked to national cancer registry and hospitalisation data (2006–2018), to create a study population of people aged 15 years and older with one of four cancer diagnoses: lung, prostate, breast and colorectal. The exposure group included people with a history of mental health/addiction service contact within the five years before cancer diagnosis, with a subgroup of people with a diagnosis of bipolar disorder, schizophrenia or psychotic disorders. Marginal standardised rates were used to compare emergency presentations (hospital admission within 30 days of cancer diagnosis) in the exposure and comparison groups, adjusted for age, gender (for lung and colorectal cancers), ethnicity, area deprivation and stage at diagnosis. Results For all four cancers, the rates of emergency presentation in the fully adjusted models were significantly higher in people with a history of mental health/addiction service use than people without (lung cancer, RR 1.19, 95% CI 1.13, 1.24; prostate cancer RR 1.69, 95% CI 1.44, 1.93; breast cancer RR 1.42, 95% CI 1.14, 1.69; colorectal cancer 1.31, 95% CI 1.22, 1.39). Rates were substantially higher in those with a diagnosis of schizophrenia, bipolar disorder or psychotic disorders. Conclusions Implementing pathways for earlier detection and diagnosis of cancers in people with MHSUC could reduce the rates of emergency presentation, with improved cancer survival outcomes. All health services, including cancer screening programmes, primary and secondary care, have a responsibility to ensure equitable access to healthcare for people with MHSUC.
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- 2024
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23. JWST/NIRCam Coronagraphy: Commissioning and First On-Sky Results
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Girard, Julien H., Leisenring, Jarron, Kammerer, Jens, Gennaro, Mario, Rieke, Marcia, Stansberry, John, Rest, Armin, Egami, Eiichi, Sunnquist, Ben, Boyer, Martha, Canipe, Alicia, Correnti, Matteo, Hilbert, Bryan, Perrin, Marshall D., Pueyo, Laurent, Soummer, Remi, Allen, Marsha, Bushouse, Howard, Aguilar, Jonathan, Brooks, Brian, Coe, Dan, DiFelice, Audrey, Golimowski, David, Hartig, George, Hines, Dean C., Koekemoer, Anton, Nickson, Bryony, Nikolov, Nikolay, Kozhurina-Platais, Vera, Pirzkal, Nor, Robberto, Massimo, Sivaramakrishnan, Anand, Sohn, Sangmo Tony, Telfer, Randal, Wu, Chi Rai, Beatty, Thomas, Florian, Michael, Hainline, Kevin, Kelly, Doug, Misselt, Karl, Schlawin, Everett, Sun, Fengwu, Williams, Christina, Willmer, Christopher, Stark, Christopher, Ygouf, Marie, Carter, Aarynn, Beichman, Charles, Greene, Thomas P., Roellig, Thomas, Krist, John, Redai, Jéa Adams, Wang, Jason, Clark, Charles R., Lewis, Dan, and Ferry, Malcolm
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Instrumentation and Detectors ,Physics - Optics - Abstract
In a cold and stable space environment, the James Webb Space Telescope (JWST or "Webb") reaches unprecedented sensitivities at wavelengths beyond 2 microns, serving most fields of astrophysics. It also extends the parameter space of high-contrast imaging in the near and mid-infrared. Launched in late 2021, JWST underwent a six month commissioning period. In this contribution we focus on the NIRCam Coronagraphy mode which was declared "science ready" on July 10 2022, the last of the 17 JWST observing modes. Essentially, this mode will allow to detect fainter/redder/colder (less massive for a given age) self-luminous exoplanets as well as other faint astrophysical signal in the vicinity of any bright object (stars or galaxies). Here we describe some of the steps and hurdles the commissioning team went through to achieve excellent performances. Specifically, we focus on the Coronagraphic Suppression Verification activity. We were able to produce firm detections at 3.35$\mu$m of the white dwarf companion HD 114174 B which is at a separation of $\simeq$ 0.5" and a contrast of $\simeq$ 10 magnitudes ($10^{4}$ fainter than the K$\sim$5.3 mag host star). We compare these first on-sky images with our latest, most informed and realistic end-to-end simulations through the same pipeline. Additionally we provide information on how we succeeded with the target acquisition with all five NIRCam focal plane masks and their four corresponding wedged Lyot stops., Comment: 23 pages, 18 figures, to appear in the Proceedings of the SPIE Astronomical Telescopes + Instrumentation (2022)
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- 2022
24. The Science Performance of JWST as Characterized in Commissioning
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Rigby, Jane, Perrin, Marshall, McElwain, Michael, Kimble, Randy, Friedman, Scott, Lallo, Matt, Doyon, René, Feinberg, Lee, Ferruit, Pierre, Glasse, Alistair, Rieke, Marcia, Rieke, George, Wright, Gillian, Willott, Chris, Colon, Knicole, Milam, Stefanie, Neff, Susan, Stark, Christopher, Valenti, Jeff, Abell, Jim, Abney, Faith, Abul-Huda, Yasin, Acton, D. Scott, Adams, Evan, Adler, David, Aguilar, Jonathan, Ahmed, Nasif, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Marsha, Altenburg, Martin, Marquez, Javier Alvarez, de Oliveira, Catarina Alves, Andersen, Greg, Anderson, Harry, Anderson, Sara, Argyriou, Ioannis, Armstrong, Amber, Arribas, Santiago, Artigau, Etienne, Arvai, Amanda, Atkinson, Charles, Bacon, Gregory, Bair, Thomas, Banks, Kimberly, Barrientes, Jaclyn, Barringer, Bruce, Bartosik, Peter, Bast, William, Baudoz, Pierre, Beatty, Thomas, Bechtold, Katie, Beck, Tracy, Bergeron, Eddie, Bergkoetter, Matthew, Bhatawdekar, Rachana, Birkmann, Stephan, Blazek, Ronald, Blome, Claire, Boccaletti, Anthony, Boeker, Torsten, Boia, John, Bonaventura, Nina, Bond, Nicholas, Bosley, Kari, Boucarut, Ray, Bourque, Matthew, Bouwman, Jeroen, Bower, Gary, Bowers, Charles, Boyer, Martha, Bradley, Larry, Brady, Greg, Braun, Hannah, Breda, David, Bresnahan, Pamela, Bright, Stacey, Britt, Christopher, Bromenschenkel, Asa, Brooks, Brian, Brooks, Keira, Brown, Bob, Brown, Matthew, Brown, Patricia, Bunker, Andy, Burger, Matthew, Bushouse, Howard, Cale, Steven, Cameron, Alex, Cameron, Peter, Canipe, Alicia, Caplinger, James, Caputo, Francis, Cara, Mihai, Carey, Larkin, Carniani, Stefano, Carrasquilla, Maria, Carruthers, Margaret, Case, Michael, Catherine, Riggs, Chance, Don, Chapman, George, Charlot, Stéphane, Charlow, Brian, Chayer, Pierre, Chen, Bin, Cherinka, Brian, Chichester, Sarah, Chilton, Zack, Chonis, Taylor, Clampin, Mark, Clark, Charles, Clark, Kerry, Coe, Dan, Coleman, Benee, Comber, Brian, Comeau, Tom, Connolly, Dennis, Cooper, James, Cooper, Rachel, Coppock, Eric, Correnti, Matteo, Cossou, Christophe, Coulais, Alain, Coyle, Laura, Cracraft, Misty, Curti, Mirko, Cuturic, Steven, Davis, Katherine, Davis, Michael, Dean, Bruce, DeLisa, Amy, deMeester, Wim, Dencheva, Nadia, Dencheva, Nadezhda, DePasquale, Joseph, Deschenes, Jeremy, Detre, Örs Hunor, Diaz, Rosa, Dicken, Dan, DiFelice, Audrey, Dillman, Matthew, Dixon, William, Doggett, Jesse, Donaldson, Tom, Douglas, Rob, DuPrie, Kimberly, Dupuis, Jean, Durning, John, Easmin, Nilufar, Eck, Weston, Edeani, Chinwe, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan, Eisenhower, Michael, Elie, Michelle, Elliott, James, Elliott, Kyle, Ellis, Tracy, Engesser, Michael, Espinoza, Nestor, Etienne, Odessa, Etxaluze, Mireya, Falini, Patrick, Feeney, Matthew, Ferry, Malcolm, Filippazzo, Joseph, Fincham, Brian, Fix, Mees, Flagey, Nicolas, Florian, Michael, Flynn, Jim, Fontanella, Erin, Ford, Terrance, Forshay, Peter, Fox, Ori, Franz, David, Fu, Henry, Fullerton, Alexander, Galkin, Sergey, Galyer, Anthony, Marin, Macarena Garcia, Gardner, Jonathan, Gardner, Lisa, Garland, Dennis, Garrett, Bruce, Gasman, Danny, Gaspar, Andras, Gaudreau, Daniel, Gauthier, Peter, Geers, Vincent, Geithner, Paul, Gennaro, Mario, Giardino, Giovanna, Girard, Julien, Giuliano, Mark, Glassmire, Kirk, Glauser, Adrian, Glazer, Stuart, Godfrey, John, Golimowski, David, Gollnitz, David, Gong, Fan, Gonzaga, Shireen, Gordon, Michael, Gordon, Karl, Goudfrooij, Paul, Greene, Thomas, Greenhouse, Matthew, Grimaldi, Stefano, Groebner, Andrew, Grundy, Timothy, Guillard, Pierre, Gutman, Irvin, Ha, Kong Q., Haderlein, Peter, Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest, Hammel, Heidi, Hansen, Carl, Harkins, Tom, Harr, Michael, Hart, Jessica, Hart, Quyen, Hartig, George, Hashimoto, Ryan, Haskins, Sujee, Hathaway, William, Havey, Keith, Hayden, Brian, Hecht, Karen, Heller-Boyer, Chris, Henriques, Caroline, Henry, Alaina, Hermann, Karl, Hernandez, Scarlin, Hesman, Brigette, Hicks, Brian, Hilbert, Bryan, Hines, Dean, Hoffman, Melissa, Holfeltz, Sherie, Holler, Bryan J., Hoppa, Jennifer, Hott, Kyle, Howard, Joseph, Howard, Rick, Hunter, Alexander, Hunter, David, Hurst, Brendan, Husemann, Bernd, Hustak, Leah, Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra, Jackson, Wallace, Jahromi, Amir, Jakobsen, Peter, James, LeAndrea, James, Bryan, Januszewski, William, Jenkins, Ann, Jirdeh, Hussein, Johnson, Phillip, Johnson, Timothy, Jones, Vicki, Jones, Ron, Jones, Danny, Jones, Olivia, Jordan, Ian, Jordan, Margaret, Jurczyk, Sarah, Jurling, Alden, Kaleida, Catherine, Kalmanson, Phillip, Kammerer, Jens, Kang, Huijo, Kao, Shaw-Hong, Karakla, Diane, Kavanagh, Patrick, Kelly, Doug, Kendrew, Sarah, Kennedy, Herbert, Kenny, Deborah, Keski-kuha, Ritva, Keyes, Charles, Kidwell, Richard, Kinzel, Wayne, Kirk, Jeff, Kirkpatrick, Mark, Kirshenblat, Danielle, Klaassen, Pamela, Knapp, Bryan, Knight, J. Scott, Knollenberg, Perry, Koehler, Robert, Koekemoer, Anton, Kovacs, Aiden, Kulp, Trey, Kumari, Nimisha, Kyprianou, Mark, La Massa, Stephanie, Labador, Aurora, Ortega, Alvaro Labiano, Lagage, Pierre-Olivier, Lajoie, Charles-Phillipe, Lallo, Matthew, Lam, May, Lamb, Tracy, Lambros, Scott, Lampenfield, Richard, Langston, James, Larson, Kirsten, Law, David, Lawrence, Jon, Lee, David, Leisenring, Jarron, Lepo, Kelly, Leveille, Michael, Levenson, Nancy, Levine, Marie, Levy, Zena, Lewis, Dan, Lewis, Hannah, Libralato, Mattia, Lightsey, Paul, Link, Miranda, Liu, Lily, Lo, Amy, Lockwood, Alexandra, Logue, Ryan, Long, Chris, Long, Douglas, Loomis, Charles, Lopez-Caniego, Marcos, Alvarez, Jose Lorenzo, Love-Pruitt, Jennifer, Lucy, Adrian, Luetzgendorf, Nora, Maghami, Peiman, Maiolino, Roberto, Major, Melissa, Malla, Sunita, Malumuth, Eliot, Manjavacas, Elena, Mannfolk, Crystal, Marrione, Amanda, Marston, Anthony, Martel, André, Maschmann, Marc, Masci, Gregory, Masciarelli, Michaela, Maszkiewicz, Michael, Mather, John, McKenzie, Kenny, McLean, Brian, McMaster, Matthew, Melbourne, Katie, Meléndez, Marcio, Menzel, Michael, Merz, Kaiya, Meyett, Michele, Meza, Luis, Miskey, Cherie, Misselt, Karl, Moller, Christopher, Morrison, Jane, Morse, Ernie, Moseley, Harvey, Mosier, Gary, Mountain, Matt, Mueckay, Julio, Mueller, Michael, Mullally, Susan, Murphy, Jess, Murray, Katherine, Murray, Claire, Mustelier, David, Muzerolle, James, Mycroft, Matthew, Myers, Richard, Myrick, Kaila, Nanavati, Shashvat, Nance, Elizabeth, Nayak, Omnarayani, Naylor, Bret, Nelan, Edmund, Nickson, Bryony, Nielson, Alethea, Nieto-Santisteban, Maria, Nikolov, Nikolay, Noriega-Crespo, Alberto, O'Shaughnessy, Brian, O'Sullivan, Brian, Ochs, William, Ogle, Patrick, Oleszczuk, Brenda, Olmsted, Joseph, Osborne, Shannon, Ottens, Richard, Owens, Beverly, Pacifici, Camilla, Pagan, Alyssa, Page, James, Park, Sang, Parrish, Keith, Patapis, Polychronis, Paul, Lee, Pauly, Tyler, Pavlovsky, Cheryl, Pedder, Andrew, Peek, Matthew, Pena-Guerrero, Maria, Pennanen, Konstantin, Perez, Yesenia, Perna, Michele, Perriello, Beth, Phillips, Kevin, Pietraszkiewicz, Martin, Pinaud, Jean-Paul, Pirzkal, Norbert, Pitman, Joseph, Piwowar, Aidan, Platais, Vera, Player, Danielle, Plesha, Rachel, Pollizi, Joe, Polster, Ethan, Pontoppidan, Klaus, Porterfield, Blair, Proffitt, Charles, Pueyo, Laurent, Pulliam, Christine, Quirt, Brian, Neira, Irma Quispe, Alarcon, Rafael Ramos, Ramsay, Leah, Rapp, Greg, Rapp, Robert, Rauscher, Bernard, Ravindranath, Swara, Rawle, Timothy, Regan, Michael, Reichard, Timothy A., Reis, Carl, Ressler, Michael E., Rest, Armin, Reynolds, Paul, Rhue, Timothy, Richon, Karen, Rickman, Emily, Ridgaway, Michael, Ritchie, Christine, Rix, Hans-Walter, Robberto, Massimo, Robinson, Gregory, Robinson, Michael, Robinson, Orion, Rock, Frank, Rodriguez, David, Del Pino, Bruno Rodriguez, Roellig, Thomas, Rohrbach, Scott, Roman, Anthony, Romelfanger, Fred, Rose, Perry, Roteliuk, Anthony, Roth, Marc, Rothwell, Braden, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Royle, Patricia, Rui, Chunlei, Rumler, Peter, Runnels, Joel, Russ, Melissa, Rustamkulov, Zafar, Ryden, Grant, Ryer, Holly, Sabata, Modhumita, Sabatke, Derek, Sabbi, Elena, Samuelson, Bridget, Sapp, Benjamin, Sappington, Bradley, Sargent, B., Sauer, Arne, Scheithauer, Silvia, Schlawin, Everett, Schlitz, Joseph, Schmitz, Tyler, Schneider, Analyn, Schreiber, Jürgen, Schulze, Vonessa, Schwab, Ryan, Scott, John, Sembach, Kenneth, Shanahan, Clare, Shaughnessy, Bryan, Shaw, Richard, Shawger, Nanci, Shay, Christopher, Sheehan, Evan, Shen, Sharon, Sherman, Allan, Shiao, Bernard, Shih, Hsin-Yi, Shivaei, Irene, Sienkiewicz, Matthew, Sing, David, Sirianni, Marco, Sivaramakrishnan, Anand, Skipper, Joy, Sloan, Gregory, Slocum, Christine, Slowinski, Steven, Smith, Erin, Smith, Eric, Smith, Denise, Smith, Corbett, Snyder, Gregory, Soh, Warren, Sohn, Tony, Soto, Christian, Spencer, Richard, Stallcup, Scott, Stansberry, John, Starr, Carl, Starr, Elysia, Stewart, Alphonso, Stiavelli, Massimo, Straughn, Amber, Strickland, David, Stys, Jeff, Summers, Francis, Sun, Fengwu, Sunnquist, Ben, Swade, Daryl, Swam, Michael, Swaters, Robert, Swoish, Robby, Taylor, Joanna M., Taylor, Rolanda, Plate, Maurice Te, Tea, Mason, Teague, Kelly, Telfer, Randal, Temim, Tea, Thatte, Deepashri, Thompson, Christopher, Thompson, Linda, Thomson, Shaun, Tikkanen, Tuomo, Tippet, William, Todd, Connor, Toolan, Sharon, Tran, Hien, Trejo, Edwin, Truong, Justin, Tsukamoto, Chris, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael, Van Campen, Julie, Vandal, Thomas, Vandenbussche, Bart, Vila, Begoña, Volk, Kevin, Wahlgren, Glenn, Waldman, Mark, Walker, Chanda, Wander, Michel, Warfield, Christine, Warner, Gerald, Wasiak, Matthew, Watkins, Mitchell, Weaver, Andrew, Weilert, Mark, Weiser, Nick, Weiss, Ben, Weissman, Sarah, Welty, Alan, West, Garrett, Wheate, Lauren, Wheatley, Elizabeth, Wheeler, Thomas, White, Rick, Whiteaker, Kevin, Whitehouse, Paul, Whiteleather, Jennifer, Whitman, William, Williams, Christina, Willmer, Christopher, Willoughby, Scott, Wilson, Andrew, Wirth, Gregory, Wislowski, Emily, Wolf, Erin, Wolfe, David, Wolff, Schuyler, Workman, Bill, Wright, Ray, Wu, Carl, Wu, Rai, Wymer, Kristen, Yates, Kayla, Yeager, Christopher, Yeates, Jared, Yerger, Ethan, Yoon, Jinmi, Young, Alice, Yu, Susan, Zak, Dean, Zeidler, Peter, Zhou, Julia, Zielinski, Thomas, Zincke, Cristian, and Zonak, Stephanie
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies., Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb293
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- 2022
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25. The genome sequence of an Entiminae weevil, Polydrusus pterygomalis Boheman, 1840 [version 1; peer review: 2 approved]
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Mark G. Telfer and James Bickerstaff
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Polydrusus pterygomalis ,Entiminae weevil ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Entiminae weevil, Polydrusus pterygomalis (Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence has a total length of 1,051.50 megabases. Most of the assembly is scaffolded into 11 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 20.95 kilobases in length.
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- 2024
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26. The genome sequence of the Dogs-Mercury Flea Beetle, Hermaeophaga mercurialis (Fabricius, 1792) [version 1; peer review: 2 approved]
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Dominic Phillips, Maxwell V. L. Barclay, Mark Telfer, and Liam M. Crowley
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Hermaeophaga mercurialis ,Dogs-Mercury Flea Beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual Dogs-Mercury Flea Beetle, Hermaeophaga mercurialis (Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence has a length of 479.40 megabases. Most of the assembly is scaffolded into 9 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.05 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,633 protein-coding genes.
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- 2024
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27. The genome sequence of a ground beetle, Clivina fossor (Linnaeus, 1758) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Xavier Richard Badham, Mark Telfer, and Liam M. Crowley
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Clivina fossor ,a ground beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Clivina fossor (a ground beetle; Arthropoda; Insecta; Coleoptera; Carabidae). The genome sequence spans 612.60 megabases. Most of the assembly is scaffolded into 22 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.48 kilobases in length.
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- 2024
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28. Generating evidence to inform responsive and effective actions for Aboriginal and Torres Strait Islander adolescent health and well-being: a mix method protocol for evidence integration ‘the Roadmap Project’
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Alex Brown, Peter Azzopardi, Jaameeta Kurji, Karla Canuto, Rachel Reilly, Seth Westhead, Odette Pearson, Daniel McDonough, Salenna Elliott, India Shackleford, Brittney Andrews, Felicity Andrews, Sally Cooke, Mahlia Garay, Thomas Harrington, Corey Kennedy, Jaeda Lenoy, Monique Maclaine, Hannah McCleary, Lorraine Randall, Hamish Rose, Daniel Rosendale, Jakirah Telfer, Tina Brodie, and James Charles
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Medicine - Abstract
Background Australia does not have a national strategy for Aboriginal and Torres Strait Islander adolescent health and as a result, policy and programming actions are fragmented and may not be responsive to needs. Efforts to date have also rarely engaged Aboriginal and Torres Strait Islander people in co-designing solutions. The Roadmap Project aims to work in partnership with young people to define priority areas of health and well-being need and establish the corresponding developmentally appropriate, evidence-based actions.Methods and analysis All aspects of this project are governed by a group of Aboriginal and Torres Strait Islander young people. Needs, determinants and corresponding responses will be explored with Aboriginal and Torres Strait Islander adolescents (aged 10–24 years) across Australia through an online qualitative survey, interviews and focus group discussions. Parents, service providers and policy makers (stakeholders) will share their perspectives on needs and support required through interviews. Data generated will be co-analysed with the governance group and integrated with population health data, policy frameworks and evidence of effective programmes (established through reviews) to define responsive and effective actions for Aboriginal and Torres Strait Islander adolescent health and well-being.Ethics and dissemination Ethical approval for this study has been obtained from the Aboriginal Health Council of South Australia (Ref: 04-21-956), the Aboriginal Health and Medical Research Council of New South Wales (Ref: 1918/22), the Western Australian Aboriginal Health Ethics Committee (Ref: HREC1147), the Northern Territory Health and Menzies School of Health Research (Ref: 2022–4371), ACT Health Human Research Ethics Committee (Ref: 2022.ETH.00133), the St. Vincent’s Hospital, Victoria (Ref: HREC 129/22), University of Tasmania (Ref: 28020), Far North Queensland Human Research Ethics Committee (Ref: HREC/2023/QCH/89911) and Griffith University (Ref: 2023/135). Prospective adolescent participants will provide their own consent for the online survey (aged 13–24 years) and, interviews or focus group discussions (aged 15–24 years); with parental consent and adolescent assent required for younger adolescents (aged 10–14 years) participating in interviews.Study findings (priority needs and evidence-based responses) will be presented at a series of co-design workshops with adolescents and stakeholders from relevant sectors. We will also communicate findings through reports, multimedia clips and peer-reviewed publications as directed by the governance group.
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- 2024
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29. Assessment of Channel Changes Three Years after Implementation of the Salmon Habitat Enhancement, Phase 1 on Redwood Creek at Muir Woods
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Papa, Mariolina Nicolina, Jimenez, Sergio, and Telfer, Ruby
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- 2022
30. Evolution of the ToxB Gene in Pyrenophora tritici-repentis and Related Species
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Mohamed Hafez, Ryan Gourlie, Megan McDonald, Melissa Telfer, Marcelo A. Carmona, Francisco J. Sautua, Caroline S. Moffat, Paula M. Moolhuijzen, Pao Theen See, and Reem Aboukhaddour
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haplotypes ,host-selective toxins ,necrotrophic fungal pathogens ,retrotransposons ,tan spot ,toxb homolog ,Microbiology ,QR1-502 ,Botany ,QK1-989 - Abstract
Pyrenophora tritici-repentis (tan spot) is a destructive foliar pathogen of wheat with global impact. This ascomycete fungus possesses a highly plastic open pangenome shaped by the gain and loss of effector genes. This study investigated the allelic variations in the chlorosis-encoding gene ToxB across 422 isolates representing all identified pathotypes and worldwide origins. To gain better insights into ToxB evolution, we examined its presence and variability in other Pyrenophora spp. A ToxB haplotype network was constructed, revealing the evolutionary relationships of this gene (20 haplotypes) across four Pyrenophora species. Notably, toxb, the homolog of ToxB, was detected for the first time in the barley pathogen Pyrenophora teres. The ToxB/toxb genes display evidence of selection that is characterized by loss of function, duplication, and diverse mutations. Within the ToxB/toxb open reading frame, 72 mutations were identified, including 14 synonymous, 55 nonsynonymous, and 3 indel mutations. Remarkably, a, ∼5.6-kb Copia-like retrotransposon, named Copia-1_Ptr, was found inserted in the toxb gene of a race 3 isolate. This insert disrupted the ToxB gene's function, a first case of effector gene disruption by a transposable element in P. tritici-repentis. Additionally, a microsatellite with 25 nucleotide repeats (0 to 10) in the upstream region of ToxB suggested a potential mechanism influencing ToxB expression and regulation. Exploring ToxB-like protein distribution in other ascomycetes revealed the presence of ToxB-like proteins in 19 additional species, including the Leotiomycetes class for the first time. The presence/absence pattern of ToxB-like proteins defied species relatedness compared with a phylogenetic tree, suggesting a past horizontal gene transfer event during the evolution of the ToxB gene. [Graphic: see text] Copyright © 2024 His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food. This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
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- 2024
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31. The bii4africa dataset of faunal and floral population intactness estimates across Africa’s major land uses
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Hayley S. Clements, Emmanuel Do Linh San, Gareth Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Reinette Biggs, Alta De Vos, Ryan Blanchard, Matthew Child, Karen J. Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Andrew L. Skowno, Tshegofatso Tshoke, Diarrassouba Abdoulaye, Thierry Aebischer, Jesús Aguirre-Gutiérrez, Graham J. Alexander, Abdullahi H. Ali, David G. Allan, Esther E. Amoako, Samuel Angedakin, Edward Aruna, Nico L. Avenant, Gabriel Badjedjea, Adama Bakayoko, Abraham Bamba-kaya, Michael F. Bates, Paul J. J. Bates, Steven R. Belmain, Emily Bennitt, James Bradley, Chris A. Brewster, Michael B. Brown, Michelle Brown, Josef Bryja, Thomas M. Butynski, Filipe Carvalho, Alan Channing, Colin A. Chapman, Callan Cohen, Marina Cords, Jennifer D. Cramer, Nadine Cronk, Pamela M. K. Cunneyworth, Fredrik Dalerum, Emmanuel Danquah, Harriet T. Davies-Mostert, Andrew D. de Blocq, Yvonne A. De Jong, Terrence C. Demos, Christiane Denys, Chabi A. M. S. Djagoun, Thomas M. Doherty-Bone, Marine Drouilly, Johan T. du Toit, David A. Ehlers Smith, Yvette C. Ehlers Smith, Seth J. Eiseb, Peter J. Fashing, Adam W. Ferguson, José M. Fernández-García, Manfred Finckh, Claude Fischer, Edson Gandiwa, Philippe Gaubert, Jerome Y. Gaugris, Dalton J. Gibbs, Jason S. Gilchrist, Jose M. Gil-Sánchez, Anthony N. Githitho, Peter S. Goodman, Laurent Granjon, J. Paul Grobler, Bonginkosi C. Gumbi, Vaclav Gvozdik, James Harvey, Morgan Hauptfleisch, Firas Hayder, Emmanuel M. Hema, Marna Herbst, Mariano Houngbédji, Brian J. Huntley, Rainer Hutterer, Samuel T. Ivande, Kate Jackson, Gregory F. M. Jongsma, Javier Juste, Blaise Kadjo, Prince K. Kaleme, Edwin Kamugisha, Beth A. Kaplin, Humphrey N. Kato, Christian Kiffner, Duncan M. Kimuyu, Robert M. Kityo, N’goran G. Kouamé, Marcel Kouete T, Aliza le Roux, Alan T. K. Lee, Mervyn C. Lötter, Anne Mette Lykke, Duncan N. MacFadyen, Gacheru P. Macharia, Zimkitha J. K. Madikiza, Themb’alilahlwa A. M. Mahlaba, David Mallon, Mnqobi L. Mamba, Claude Mande, Rob A. Marchant, Robin A. Maritz, Wanda Markotter, Trevor McIntyre, John Measey, Addisu Mekonnen, Paulina Meller, Haemish I. Melville, Kevin Z. Mganga, Michael G. L. Mills, Liaan Minnie, Alain Didier Missoup, Abubakr Mohammad, Nancy N. Moinde, Bakwo Fils E. Moise, Pedro Monterroso, Jennifer F. Moore, Simon Musila, Sedjro Gilles A. Nago, Maganizo W. Namoto, Fatimata Niang, Violaine Nicolas, Jerry B. Nkenku, Evans E. Nkrumah, Gonwouo L. Nono, Mulavwa M. Norbert, Katarzyna Nowak, Benneth C. Obitte, Arnold D. Okoni-Williams, Jonathan Onongo, M. Justin O’Riain, Samuel T. Osinubi, Daniel M. Parker, Francesca Parrini, Mike J. S. Peel, Johannes Penner, Darren W. Pietersen, Andrew J. Plumptre, Damian W. Ponsonby, Stefan Porembski, R. John Power, Frans G. T. Radloff, Ramugondo V. Rambau, Tharmalingam Ramesh, Leigh R. Richards, Mark-Oliver Rödel, Dominic P. Rollinson, Francesco Rovero, Mostafa A. Saleh, Ute Schmiedel, M. Corrie Schoeman, Paul Scholte, Thomas L. Serfass, Julie Teresa Shapiro, Sidney Shema, Stefan J. Siebert, Jasper A. Slingsby, Alexander Sliwa, Hanneline A. Smit-Robinson, Etotepe A. Sogbohossou, Michael J. Somers, Stephen Spawls, Jarryd P. Streicher, Lourens Swanepoel, Iroro Tanshi, Peter J. Taylor, William A. Taylor, Mariska te Beest, Paul T. Telfer, Dave I. Thompson, Elie Tobi, Krystal A. Tolley, Andrew A. Turner, Wayne Twine, Victor Van Cakenberghe, Frederik Van de Perre, Helga van der Merwe, Chris J. G. van Niekerk, Pieter C. V. van Wyk, Jan A. Venter, Luke Verburgt, Geraldine Veron, Susanne Vetter, Maria S. Vorontsova, Thomas C. Wagner, Paul W. Webala, Natalie Weber, Sina M. Weier, Paula A. White, Melissa A. Whitecross, Benjamin J. Wigley, Frank J. Willems, Christiaan W. Winterbach, and Galena M. Woodhouse
- Subjects
Science - Abstract
Abstract Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species’ population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate ‘intactness scores’: the remaining proportion of an ‘intact’ reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes). The resulting bii4africa dataset contains intactness scores representing terrestrial vertebrates (tetrapods: ±5,400 amphibians, reptiles, birds, mammals) and vascular plants (±45,000 forbs, graminoids, trees, shrubs) in sub-Saharan Africa across the region’s major land uses (urban, cropland, rangeland, plantation, protected, etc.) and intensities (e.g., large-scale vs smallholder cropland). This dataset was co-produced as part of the Biodiversity Intactness Index for Africa Project. Additional uses include assessing ecosystem condition; rectifying geographic/taxonomic biases in global biodiversity indicators and maps; and informing the Red List of Ecosystems.
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- 2024
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32. Microbubble Contrast Agents Improve Detection of Active Hemorrhage
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Scott Schoen Jr, Alexis Prasov, Ion Candel, Saaid Arshad, Mark Ottensmeyer, Theodore T. Pierce, Laura J. Brattain, Brian A. Telfer, and Anthony E. Samir
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Trauma ,hemorrhage ,contrast agents ,ultrasound ,doppler ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
Assessment of trauma-induced hemorrhage with ultrasound is particularly challenging outside of the clinic, where its detection is crucial. The current clinical standard for hematoma detection – the focused assessment with sonography of trauma (FAST) exam – does not aim to detect ongoing blood loss, and thus is unable to detect injuries of increasing severity. To enhance detection of active bleeding, we propose the use of ultrasound contrast agents (UCAs), together with a novel flow phantom and contrast-sensitive processing techniques, to facilitate efficient, practical characterization of internal bleeding. Within a the custom phantom, UCAs and processing techniques enabled a significant enhancement of the hemorrhage visualization (mean increase in generalized contrast-to-noise ratio of 17%) compared to the contrast-free case over a range of flow rates up to 40 ml/min. Moreover, we have shown that the use of UCAs improves the probability of detection: the area under the receiver operating characteristic curve for a flow rate of 40 ml/min was 0.99, compared to 0.72 without contrast. We also demonstrate how additional processing of the spatial and temporal information further localizes the bleeding site. UCAs also enhanced Doppler signals over the non-contrast case. These results show that specialized nonlinear processing (NLP) pipelines together with UCAs may offer an efficient means to improve substantially the detection of slower hemorrhages and increase survival rates for trauma-induced injury in pre-hospital settings.
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- 2024
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33. Canadians’ knowledge of cancer risk factors and belief in cancer myths
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Rydz E, Telfer J, Quinn EK, Fazel SS, Holmes E, Pennycook G, and Peters CE
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Cancer ,Cancer beliefs ,Cancer myths ,Cancer misinformation ,Awareness ,Thinking disposition ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Many untrue statements about cancer prevention and risks are circulating. The objective of this study was to assess Canadians’ awareness of known cancer risk factors and cancer myths (untruths or statements that are not completely true), and to explore how awareness may vary by sociodemographic and cognitive factors. Methods Cancer myths were identified by conducting scans of published, grey literature, and social media. Intuitive-analytic thinking disposition scores included were actively open- and close-minded thinking, as well as preference for intuitive and effortful thinking. A survey was administered online to participants aged 18 years and older through Prolific. Results were summarized descriptively and analyzed using chi-square tests, as well as Spearman rank and Pearson correlations. Results Responses from 734 Canadians were received. Participants were better at identifying known cancer risk factors (70% of known risks) compared to cancer myths (49%). Bivariate analyses showed differential awareness of known cancer risk factors (p 90% correctly identified), but recognition of other known risk factors was poor (as low as 23% for low vegetable and fruit intake). Mythical cancer risk factors with high support were consuming additives (61%), feeling stressed (52%), and consuming artificial sweeteners (49%). High uncertainty of causation was observed for glyphosate (66% neither agreed or disagreed). For factors that reduce cancer risk, reasonable awareness was observed for HPV vaccination (60%), but there was a high prevalence in cancer myths, particularly that consuming antioxidants (65%) and organic foods (45%) are protective, and some uncertainty whether drinking red wine (41%), consuming vitamins (32%), and smoking cannabis (30%) reduces cancer risk. Conclusions While Canadians were able to identify tobacco-related cancer risk factors, many myths were believed and numerous risk factors were not recognized. Cancer myths can be harmful in themselves and can detract the public’s attention from and action on established risk factors.
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- 2024
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34. Hetero-interpenetrated metal–organic frameworks
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Perl, David, Lee, Seok J., Ferguson, Alan, Jameson, Geoffrey B., and Telfer, Shane G.
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- 2023
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35. Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
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Dunlop, CE, Jack, SA, Telfer, EE, Zahra, S., and Anderson, RA
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- 2023
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36. The genome sequence of the flea beetle, Crepidodera aurea (Geoffrey, 1785) [version 1; peer review: 2 approved]
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Mark G. Telfer and Hermione Blomfield-Smith
- Subjects
Crepidodera aurea ,flea beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Crepidodera aurea (flea beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence is 509.0 megabases in span. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 18.69 kilobases in length. Gene annotation of this assembly on Ensembl identified 19,944 protein coding genes.
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- 2024
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37. The genome sequence of the oak pinhole borer, Platypus cylindrus Fabricius, 1792 [version 1; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Maxwell V. L. Barclay, Keita Matsumoto, Danaë Vassiliades, Joana Cristóvão, Michael Geiser, and Will Bayfield Farrell
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Platypus cylindrus ,oak pinhole borer ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Platypus cylindrus (the oak pinhole borer; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 147.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,468 protein coding genes.
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- 2024
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38. Heavy metal contamination of the sea cucumber Holothuria poli cultured in integrated multi-trophic aquaculture in a multi-use coastal area
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Karl Cutajar, Lynne Falconer, and Trevor C. Telfer
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Sea cucumber ,IMTA ,Heavy metals, contaminant transfer ,Bioaccumulation ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
The accumulation of heavy metals in the edible tissue of the white spot sea cucumber, Holothuria poli, revealed the transfer of metal contaminants to sea cucumbers when produced below fish cages in a Mediterranean port area. Sea cucumbers were cultured on the seafloor directly below a fish cage at 0 m, then at 10 m and at 25 m away from the cage, as part of an open-water integrated multi-trophic aquaculture (IMTA) system, and then at a reference site over 1 km from the fish farm, over a one-year period. At the end of the study, sea cucumbers and seafloor sediments were sampled from the IMTA sites near the fish cages, except at 0 m due to mass sea cucumber mortalities within the first month of the study, and again at the reference site. The concentrations of cadmium (Cd), copper (Cu), chromium (Cr), nickel (Ni), and zinc (Zn) were significantly higher in sediments near fish cages than the reference site. Localised enrichment from marine aquaculture could explain the significant concentration of metals in sediments below fish cages that are typically ascribed to their use in aquaculture. Arsenic (As), lead (Pb) and mercury (Hg), which are not associated with commercial fish diets, did not vary between sites. Concentrations of iron (Fe), which is available in commercial diets, were similar near fish cages and at the reference site. The body wall/muscle tissue of the sea cucumber. H. poli revealed high concentrations of the essential metals Fe and Zn near fish cages and in natural sediments at the reference site. H. poli can regulate these essential metals that characterised the edible tissue of the sea cucumbers. Non-essential metals like Hg and Cd had the lowest concentrations of all analysed metals in the sea cucumber tissue. However, the bioaccumulation of toxic metals, Hg and As, reveal the bioavailability of these contaminants in sediments and the propensity of bottom-dwelling sea cucumbers to bioconcentrate these metals, when cultured under a commercial fish cage in IMTA and elsewhere in natural sediments in this industrial environment. Holothuria poli did not exhibit bioaccumulation of Cu, Cr, Fe, Ni, Pb and Zn in its body wall/muscle tissue. The bioaccumulation of Hg and As reveal the need to account for the potential effects of farm-level variability throughout longer production cycles and bay-wide dynamics on sediment contamination and bioaccumulation in sea cucumbers until harvest. Site-specific dynamics in ports, whether natural or anthropogenic, can be expected to influence bioaccumulation of metal contaminants and therefore require long-term and fine resolution monitoring for better representation in open-water IMTA production.
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- 2024
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39. Exploring alternative education: a comparison on 3 levels—Waldorf charters, non-Waldorf charters, and local public schools, as measured by the California Assessment of Student Performance and Progress
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Kimberly Telfer-Radzat
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Waldorf education ,CAASPP ,charter schools ,testing outcomes ,holistic education ,Education (General) ,L7-991 - Abstract
As the number of students enrolled in charter schools grows across the country, so do questions about their impact on academic outcomes (National Center for Educational Statistics). Given the importance of student test scores as evidence of success at the state, school, classroom, and teacher levels, understanding the effect of these charter schools' pedagogies on student outcomes is critical. Waldorf-inspired charter schools are one such growing alternative pedagogy. This study answers the question: Is there any significant difference between the levels of achievement for students in English Language Arts and math who are enrolled in Waldorf-inspired charter schools vs. those in either local public school classrooms or other charter classrooms that do not use the Waldorf pedagogy? Using OLS multiple linear regression this study examined the significance of the levels of achievement in English Language Arts (ELA) and math among students in 16 Waldorf-inspired charter schools and other charter and non-charter schools in California, using the California Assessment of Student Performance and Progress (CAASPP) scores. The research revealed that there are significantly higher percentages of eighth-grade students in Waldorf-inspired charter schools meeting or exceeding state standards in ELA and math as compared to their non-Waldorf charter school comparison groups, even when controlling for the size of the school, socioeconomic status, and district-level fixed effects (p < 0.01). This is despite the significantly smaller percentage of students in these schools meeting state standards in grades three through five. The results of this study suggest that Waldorf's developmental approach to education can result in strong academic outcomes despite a slower, low-stakes approach to teaching.
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- 2024
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40. The genome sequence of the beech bark beetle, Taphrorychus bicolor (Herbst, 1793) [version 1; peer review: 2 approved]
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Mark G. Telfer and Xavier Richard Badham
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Taphrorychus bicolor ,beech bark beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Taphrorychus bicolor (the beech bark beetle; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 575.2 megabases in span. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 15.46 kilobases in length. Gene annotation of this assembly on Ensembl identified 24,125 protein coding genes.
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- 2024
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41. The genome sequence of a false flower beetle, Anaspis maculata (Geoffroy in Fourcroy, 1785) [version 1; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Dominic Phillips, and Maxwell V. L. Barclay
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Anaspis maculata ,false flower beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Anaspis maculata (false flower beetle; Arthropoda; Insecta; Coleoptera; Scraptiidae). The genome sequence is 757.8 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.31 kilobases in length. Gene annotation of this assembly on Ensembl identified 21,965 protein coding genes.
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- 2024
- Full Text
- View/download PDF
42. pressuRe: an R package for analyzing and visualizing biomechanical pressure distribution data
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Scott Telfer and Ellen Y. Li
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Medicine ,Science - Abstract
Abstract In many biomechanical analyses, the forces acting on a body during dynamic and static activities are often simplified as point loads. However, it is usually more accurate to characterize these forces as distributed loads, varying in magnitude and direction, over a given contact area. Evaluating these pressure distributions while they are applied to different parts of the body can provide effective insights for clinicians and researchers when studying health and disease conditions, for example when investigating the biomechanical factors that may lead to plantar ulceration in diabetic foot disease. At present, most processing and analysis for pressure data is performed using proprietary software, limiting reproducibility, transparency, and consistency across different studies. This paper describes an open-source software package, ‘pressuRe’, which is built in the freely available R statistical computing environment and is designed to process, analyze, and visualize pressure data collected on a range of different hardware systems in a standardized manner. We demonstrate the use of the package on pressure dataset from patients with diabetic foot disease, comparing pressure variables between those with longer and shorter durations of the disease. The results matched closely with those from commercially available software, and individuals with longer duration of diabetes were found to have higher forefoot pressures than those with shorter duration. By utilizing R’s powerful and openly available tools for statistical analysis and user customization, this package may be a useful tool for researchers and clinicians studying plantar pressures and other pressure sensor array based biomechanical measurements. With regular updates intended, this package allows for continued improvement and we welcome feedback and future contributions to extend its scope. In this article, we detail the package’s features and functionality.
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- 2023
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43. Author Correction: Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study
- Author
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Mason, Ashley E, Hecht, Frederick M, Davis, Shakti K, Natale, Joseph L, Hartogensis, Wendy, Damaso, Natalie, Claypool, Kajal T, Dilchert, Stephan, Dasgupta, Subhasis, Purawat, Shweta, Viswanath, Varun K, Klein, Amit, Chowdhary, Anoushka, Fisher, Sarah M, Anglo, Claudine, Puldon, Karena Y, Veasna, Danou, Prather, Jenifer G, Pandya, Leena S, Fox, Lindsey M, Busch, Michael, Giordano, Casey, Mercado, Brittany K, Song, Jining, Jaimes, Rafael, Baum, Brian S, Telfer, Brian A, Philipson, Casandra W, Collins, Paula P, Rao, Adam A, Wang, Edward J, Bandi, Rachel H, Choe, Bianca J, Epel, Elissa S, Epstein, Stephen K, Krasnoff, Joanne B, Lee, Marco B, Lee, Shi-Wen, Lopez, Gina M, Mehta, Arpan, Melville, Laura D, Moon, Tiffany S, Mujica-Parodi, Lilianne R, Noel, Kimberly M, Orosco, Michael A, Rideout, Jesse M, Robishaw, Janet D, Rodriguez, Robert M, Shah, Kaushal H, Siegal, Jonathan H, Gupta, Amarnath, Altintas, Ilkay, and Smarr, Benjamin L
- Subjects
Information and Computing Sciences ,Human-Centred Computing ,Good Health and Well Being - Published
- 2022
44. Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study
- Author
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Mason, Ashley E, Hecht, Frederick M, Davis, Shakti K, Natale, Joseph L, Hartogensis, Wendy, Damaso, Natalie, Claypool, Kajal T, Dilchert, Stephan, Dasgupta, Subhasis, Purawat, Shweta, Viswanath, Varun K, Klein, Amit, Chowdhary, Anoushka, Fisher, Sarah M, Anglo, Claudine, Puldon, Karena Y, Veasna, Danou, Prather, Jenifer G, Pandya, Leena S, Fox, Lindsey M, Busch, Michael, Giordano, Casey, Mercado, Brittany K, Song, Jining, Jaimes, Rafael, Baum, Brian S, Telfer, Brian A, Philipson, Casandra W, Collins, Paula P, Rao, Adam A, Wang, Edward J, Bandi, Rachel H, Choe, Bianca J, Epel, Elissa S, Epstein, Stephen K, Krasnoff, Joanne B, Lee, Marco B, Lee, Shi-Wen, Lopez, Gina M, Mehta, Arpan, Melville, Laura D, Moon, Tiffany S, Mujica-Parodi, Lilianne R, Noel, Kimberly M, Orosco, Michael A, Rideout, Jesse M, Robishaw, Janet D, Rodriguez, Robert M, Shah, Kaushal H, Siegal, Jonathan H, Gupta, Amarnath, Altintas, Ilkay, and Smarr, Benjamin L
- Subjects
Prevention ,Clinical Research ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Algorithms ,Body Temperature ,COVID-19 ,Female ,Humans ,Male ,Middle Aged ,SARS-CoV-2 ,Wearable Electronic Devices ,Young Adult - Abstract
Early detection of diseases such as COVID-19 could be a critical tool in reducing disease transmission by helping individuals recognize when they should self-isolate, seek testing, and obtain early medical intervention. Consumer wearable devices that continuously measure physiological metrics hold promise as tools for early illness detection. We gathered daily questionnaire data and physiological data using a consumer wearable (Oura Ring) from 63,153 participants, of whom 704 self-reported possible COVID-19 disease. We selected 73 of these 704 participants with reliable confirmation of COVID-19 by PCR testing and high-quality physiological data for algorithm training to identify onset of COVID-19 using machine learning classification. The algorithm identified COVID-19 an average of 2.75 days before participants sought diagnostic testing with a sensitivity of 82% and specificity of 63%. The receiving operating characteristic (ROC) area under the curve (AUC) was 0.819 (95% CI [0.809, 0.830]). Including continuous temperature yielded an AUC 4.9% higher than without this feature. For further validation, we obtained SARS CoV-2 antibody in a subset of participants and identified 10 additional participants who self-reported COVID-19 disease with antibody confirmation. The algorithm had an overall ROC AUC of 0.819 (95% CI [0.809, 0.830]), with a sensitivity of 90% and specificity of 80% in these additional participants. Finally, we observed substantial variation in accuracy based on age and biological sex. Findings highlight the importance of including temperature assessment, using continuous physiological features for alignment, and including diverse populations in algorithm development to optimize accuracy in COVID-19 detection from wearables.
- Published
- 2022
45. Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles
- Author
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Alice Spadea, Annalisa Tirella, Julio Manuel Rios de la Rosa, Enrique Lallana, Manal Mehibel, Brian Telfer, Nicola Tirelli, Margaret Jayne Lawrence, Kaye J. Williams, Ian J. Stratford, and Marianne Ashford
- Subjects
polymeric nanoparticles ,siRNA delivery ,cancer ,hyaluronic acid ,CD44 ,Pharmacy and materia medica ,RS1-441 - Abstract
Background/Objectives: Conventional anticancer therapies often lack specificity, targeting both cancerous and normal cells, which reduces efficacy and leads to undesired off-target effects. An additional challenge is the presence of hypoxic regions in tumors, where the Hypoxia Inducible Factor (HIF) transcriptional system drives the expression of pro-survival and drug resistance genes, leading to radio- and chemo-resistance. This study aims to explore the efficacy of targeted nanoparticle (NP)-based small interfering RNA (siRNA) therapies in downregulating these genes to enhance treatment outcomes in pancreatic cancer, a tumor type characterized by high CD44 expression and hypoxia. Methods: We utilized hyaluronic acid (HA)-displaying nanoparticles composed of positively charged chitosan (CS) complexed with siRNA to target and knock down HIF-1α in pancreatic cancer cells. Two NP formulations were prepared using either low molecular weight (LMW) or high molecular weight (HMW) CS. These formulations were evaluated for their internalization by cells and their effectiveness in gene silencing, both in vitro and in vivo. Results: The study found that the molecular weight (MW) of CS influenced the interaction between HA and CD44, as well as the release of siRNA upon internalization. The LMW CS formulation shows faster uptake kinetics, while HMW CS is more effective in gene knockdown across different cell lines in vitro. In vivo, both were able to significantly knockdown HIF-1α and some of its downstream genes. Conclusions: The results suggest that HMW and LMW CS-based NPs exhibit distinct characteristics, showing that both MWs have potential for targeted pancreatic cancer therapy by influencing different aspects of delivery and gene silencing, particularly in the hypoxic tumor microenvironment.
- Published
- 2024
- Full Text
- View/download PDF
46. Lines under the eyes: a large prospective case series of linear basal cell carcinomas
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Rutkowski, D., Collier, N. J., Telfer, N., and Ghura, V.
- Published
- 2023
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47. PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models
- Author
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Chun Wai Wong, Christos Evangelou, Kieran N. Sefton, Rotem Leshem, Wei Zhang, Vishaka Gopalan, Sorayut Chattrakarn, Macarena Lucia Fernandez Carro, Erez Uzuner, Holly Mole, Daniel J. Wilcock, Michael P. Smith, Kleita Sergiou, Brian A. Telfer, Dervla T. Isaac, Chang Liu, Nicholas R. Perl, Kerrie Marie, Paul Lorigan, Kaye J. Williams, Patricia E. Rao, Raghavendar T. Nagaraju, Mario Niepel, and Adam F. L. Hurlstone
- Subjects
Science - Abstract
Abstract Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular immunity, can promote ICBT resistance. Using syngeneic mouse tumour models, we confirm that chronic IFNγ exposure confers resistance to immunotherapy targeting PD-1 (α-PD-1) in immunocompetent female mice. We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNγ-treated cancer cell models, in patient melanoma with elevated IFNG expression, and in melanoma cell cultures from ICBT-progressing lesions characterised by elevated IFNγ signalling. Effector T cell infiltration is enhanced in tumours derived from cells pre-treated with IFNγ in immunocompetent female mice when PARP14 is pharmacologically inhibited or knocked down, while the presence of regulatory T cells is decreased, leading to restoration of α-PD-1 sensitivity. Finally, we determine that tumours which spontaneously relapse in immunocompetent female mice following α-PD-1 therapy upregulate IFNγ signalling and can also be re-sensitised upon receiving PARP14 inhibitor treatment, establishing PARP14 as an actionable target to reverse IFNγ-driven ICBT resistance.
- Published
- 2023
- Full Text
- View/download PDF
48. Patterns and drivers of vector-borne microparasites in a classic metapopulation
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Laura S. Mackenzie, Xavier Lambin, Emma Bryce, Claire L. Davies, Richard Hassall, Ali A. M. Shati, Chris Sutherland, and Sandra E. Telfer
- Subjects
classic metapopulation ,connectivity ,dispersal ,distance-dependent ,host ,life-history ,vector ,vector-borne ,Biochemistry ,QD415-436 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Many organisms live in fragmented populations, which has profound consequences on the dynamics of associated parasites. Metapopulation theory offers a canonical framework for predicting the effects of fragmentation on spatiotemporal host–parasite dynamics. However, empirical studies of parasites in classical metapopulations remain rare, particularly for vector-borne parasites. Here, we quantify spatiotemporal patterns and possible drivers of infection probability for several ectoparasites (fleas, Ixodes trianguliceps and Ixodes ricinus) and vector-borne microparasites (Babesia microti, Bartonella spp., Hepatozoon spp.) in a classically functioning metapopulation of water vole hosts. Results suggest that the relative importance of vector or host dynamics on microparasite infection probabilities is related to parasite life-histories. Bartonella, a microparasite with a fast life-history, was positively associated with both host and vector abundances at several spatial and temporal scales. In contrast, B. microti, a tick-borne parasite with a slow life-history, was only associated with vector dynamics. Further, we provide evidence that life-history shaped parasite dynamics, including occupancy and colonization rates, in the metapopulation. Lastly, our findings were consistent with the hypothesis that landscape connectivity was determined by distance-based dispersal of the focal hosts. We provide essential empirical evidence that contributes to the development of a comprehensive theory of metapopulation processes of vector-borne parasites.
- Published
- 2023
- Full Text
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49. Development, acceptability and feasibility of a personalised, behavioural intervention to prevent bacterial skin and soft tissue infections among people who inject drugs: a mixed-methods Person-Based Approach study
- Author
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Joanna Kesten, Deborah Hussey, Catherine Lord, Leonie Roberts, James Bayliss, Helen Erswell, Andrew Preston, Maggie Telfer, Jenny Scott, Magdalena Harris, Dominic Mellon, Matthew Hickman, Georgie MacArthur, and Harriet Fisher
- Subjects
People who inject drugs ,Skin and soft tissue infections ,Co-production ,Person-Based Approach ,Intervention development ,Acceptability ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Skin and soft tissue infections (SSTI) among people who inject drugs (PWID) are a public health concern. This study aimed to co-produce and assess the acceptability and feasibility of a behavioural intervention to prevent SSTI. Methods The Person-Based Approach (PBA) was followed which involves: (i) collating and analysing evidence; (ii) developing guiding principles; (iii) a behavioural analysis; (iv) logic model development; and (v) designing and refining intervention materials. Co-production activities with target group representatives and key collaborators obtained feedback on the intervention which was used to refine its design and content. The intervention, harm reduction advice cards to support conversation between service provider and PWID and resources to support safer injecting practice, was piloted with 13 PWID by four service providers in Bristol and evaluated using a mixed-methods approach. Semi-structured interviews were conducted with 11 PWID and four service providers. Questionnaires completed by all PWID recorded demographic characteristics, SSTI, drug use and treatment history. Interviews were analysed thematically and questionnaires were analysed descriptively. Results Published literature highlighted structural barriers to safer injecting practices, such as access to hygienic injecting environments and injecting practices associated with SSTI included: limited handwashing/injection-site swabbing and use of too much acidifier to dissolve drugs. Co-production activities and the literature indicated vein care and minimisation of pain as PWID priorities. The importance of service provider–client relationships and non-stigmatising delivery was highlighted through the co-production work. Providing practical resources was identified as important to address environmental constraints to safer injecting practices. Most participants receiving the intervention were White British, male, had a history of SSTI and on average were 43.6 years old and had injected for 22.7 years. The intervention was well-received by PWID and service providers. Intervention content and materials given out to support harm reduction were viewed positively. The intervention appeared to support reflections on and intentions to change injecting behaviours, though barriers to safer injecting practice remained prominent. Conclusions The PBA ensured the intervention aligned to the priorities of PWID. It was viewed as acceptable and mostly feasible to PWID and service providers and has transferability promise. Further implementation alongside broader harm reduction interventions is needed.
- Published
- 2023
- Full Text
- View/download PDF
50. The genome sequence of a soldier beetle, Malthinus flaveolus (Herbst, 1786) [version 1; peer review: 2 approved]
- Author
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Mark G. Telfer and Michael F. Geiser
- Subjects
Malthinus flaveolus ,soldier beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Malthinus flaveolus (soldier beetle; Arthropoda; Insecta; Coleoptera; Cantharidae). The genome sequence is 236.7 megabases in span. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 19.27 kilobases in length. Gene annotation of this assembly on Ensembl identified 16,617 protein coding genes.
- Published
- 2024
- Full Text
- View/download PDF
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